2.4.2.30 Abortion, Spontaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28042738&form=6&db=m miR-520 promotes DNA-damage-induced trophoblast cell apoptosis by targeting PARP1 in recurrent spontaneous abortion (RSA). unassigned - 2.4.2.30 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9276777&form=6&db=m Inhibitory effects of glibenclamide and pertussis toxin on the attenuation of ischemia-induced myocardial acidosis following ischemic preconditioning in dogs. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11447030&form=6&db=m Activation of poly(ADP-ribose) polymerase in severe hemorrhagic shock and resuscitation. ongoing research,unassigned 2,0 2.4.2.30 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27381826&form=6&db=m Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10537360&form=6&db=m Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents. ongoing research,unassigned 1,0 2.4.2.30 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11089573&form=6&db=m Damage and repair of DNA in HIV encephalitis. diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11049868&form=6&db=m Inhibition of poly(ADP-ribose) polymerase attenuates ischemic renal injury in rats. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14520006&form=6&db=m Effect of poly(ADP-ribose) polymerase inhibition on outer medullary hypoxic damage. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15494543&form=6&db=m Poly(ADP-ribose) polymerase-1 gene ablation protects mice from ischemic renal injury. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911333&form=6&db=m Poly(ADP-ribose) polymerase-mediated cell injury in acute renal failure. ongoing research,unassigned 3,0 2.4.2.30 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18197552&form=6&db=m Poly (ADP-ribose) polymerase as a potential target for the treatment of acute renal injury caused by lipopolysaccharide. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.4.2.30 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19833176&form=6&db=m Role of the poly(ADP-ribose)polymerase activity in vancomycin-induced renal injury. causal interaction,unassigned 3,0 2.4.2.30 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22750969&form=6&db=m Inhibition of Poly(ADP-Ribose) Polymerase Attenuates Acute Kidney Injury in Sodium Taurocholate-Induced Acute Pancreatitis in Rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25388944&form=6&db=m Poly(ADP-ribose) polymerase 1 activation links ischemic acute kidney injury to interstitial fibrosis. causal interaction,unassigned 4,0 2.4.2.30 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26184635&form=6&db=m Inhibition of Poly-(ADP-Ribose) Polymerase Protects the Kidney in a Canine Model of Endotoxic Shock. unassigned - 2.4.2.30 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27048819&form=6&db=m Regulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis? causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29238179&form=6&db=m Role of poly (ADP-ribose) polymerase-1 and cytokines in acute renal injury in elderly Chinese patients with diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.4.2.30 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29599129&form=6&db=m 5-aminoisoquinoline improves renal function and fibrosis during recovery phase of cisplatin-induced acute kidney injury in rats. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30280790&form=6&db=m Inhibition of PARP overactivation protects acute kidney injury of septic shock. causal interaction,unassigned 2,0 2.4.2.30 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1280451&form=6&db=m Murine strain differences in acute lung injury and activation of poly(ADP-ribose) polymerase by in vitro exposure of lung slices to bleomycin. causal interaction,ongoing research,unassigned 2,3,0 2.4.2.30 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14752285&form=6&db=m Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15197441&form=6&db=m Role of PARP on iNOS pathway during endotoxin-induced acute lung injury. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18718025&form=6&db=m Inflammatory and transcriptional roles of poly (ADP-ribose) polymerase in ventilator-induced lung injury. diagnostic usage,ongoing research,unassigned 2,4,0 2.4.2.30 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22995423&form=6&db=m Administration of poly(ADP-ribose) polymerase inhibitor into bronchial artery attenuates pulmonary pathophysiology after smoke inhalation and burn in an ovine model. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24278171&form=6&db=m PARP-1 inhibitor, DPQ, attenuates LPS-induced acute lung injury through inhibiting NF-?B-mediated inflammatory response. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25304310&form=6&db=m The role of poly(ADP-ribose) polymerase-1 inhibitor in carrageenan-induced lung inflammation in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25404465&form=6&db=m PARP inhibitor, olaparib ameliorates acute lung and kidney injury upon intratracheal administration of LPS in mice. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25520826&form=6&db=m The molecular mechanism of acute lung injury caused by Pseudomonas aeruginosa: from bacterial pathogenesis to host response. causal interaction,unassigned 4,0 2.4.2.30 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28931657&form=6&db=m Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. causal interaction,unassigned 3,0 2.4.2.30 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32234526&form=6&db=m Pharmacological inhibition of poly (ADP-ribose) polymerase by olaparib, prevents acute lung injury associated cognitive deficits potentially through suppression of inflammatory response. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32640172&form=6&db=m Poly(ADP-ribose) Polymerase Inhibition in Acute Lung Injury: A Re-emerging Concept. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12700925&form=6&db=m Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion. ongoing research,unassigned 3,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824873&form=6&db=m Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane. causal interaction,unassigned 3,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16890595&form=6&db=m Adenosine diphosphate ribosyl transferase and x-ray repair cross-complementing 1 polymorphisms in gastric cardia cancer. ongoing research,unassigned 4,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17252195&form=6&db=m Cyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of Bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis. causal interaction,unassigned 1,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18842335&form=6&db=m Antiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent heat shock protein 90 inhibitors in human cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19090286&form=6&db=m Evaluation of apoptosis induction using PARP cleavage on gastric adenocarcinoma and fibroblast cell lines by different strains of Helicobacter pylori. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20031160&form=6&db=m ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20944090&form=6&db=m PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21779467&form=6&db=m Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22276931&form=6&db=m Protein and phosphoprotein levels in glioma and adenocarcinoma cell lines grown in normoxia and hypoxia in monolayer and three-dimensional cultures. ongoing research,unassigned 3,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22384823&form=6&db=m High nuclear poly-(ADP-ribose)-polymerase expression is prognostic of improved survival in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23762867&form=6&db=m Hypomethylation of ETS transcription factor binding sites and upregulation of PARP1 expression in endometrial cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24536047&form=6&db=m HuR posttranscriptionally regulates WEE1: implications for the DNA damage response in pancreatic cancer cells. therapeutic application,unassigned 3,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25173886&form=6&db=m PARP-1 regulates epithelial-mesenchymal transition (EMT) in prostate tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25179837&form=6&db=m Correlation between PARP-1 Val762Ala polymorphism and the risk of lung cancer in a Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25864590&form=6&db=m Increased in vitro and in vivo sensitivity of BRCA2-associated pancreatic cancer to the poly(ADP-ribose) polymerase-1/2 inhibitor BMN 673. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25885900&form=6&db=m Annonaceous acetogenin mimic AA005 induces cancer cell death via apoptosis inducing factor through a caspase-3-independent mechanism. ongoing research,unassigned 3,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28291774&form=6&db=m BRCA2 secondary mutation-mediated resistance to platinum and PARP inhibitor-based therapy in pancreatic cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28479725&form=6&db=m Antiproliferative and Proapoptotic Activities of Marine Sponge Hyrtios erectus Extract on Breast Carcinoma Cell Line (MCF-7). ongoing research,unassigned 4,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29117515&form=6&db=m Metformin and epothilone A treatment up regulate pro-apoptotic PARP-1, Casp-3 and H2AX genes and decrease of AKT kinase level to control cell death of human hepatocellular carcinoma and ovary adenocarcinoma cells. therapeutic application,unassigned 1,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29453076&form=6&db=m Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29531462&form=6&db=m Dysregulation of PARP1 is involved in development of Barrett's esophagus. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30636012&form=6&db=m DNA Damage Repair Alterations are Frequent in Prostatic Adenocarcinomas with Focal Pleomorphic Giant Cell Features. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31002019&form=6&db=m Pancreatic acinar cell carcinoma is associated with BRCA2 germline mutations: a case report and literature review. ongoing research,unassigned 1,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31126889&form=6&db=m The BET inhibitor JQ1 attenuates double-strand break repair and sensitizes models of pancreatic ductal adenocarcinoma to PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31439587&form=6&db=m PARP Inhibition Suppresses GR-MYCN-CDK5-RB1-E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32276472&form=6&db=m Targeted PARP Inhibition Combined with FGFR1 Blockade is Synthetically Lethal to Malignant Cells in Patients with Pancreatic Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32360251&form=6&db=m Expression of poly-ADP-ribose polymerase (PARP) in endometrial adenocarcinoma: Prognostic potential. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32609666&form=6&db=m The role of PARP inhibitors in germline BRCA-associated pancreatic ductal adenocarcinoma. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32816949&form=6&db=m A Preclinical Trial and Molecularly Annotated Patient Cohort Identify Predictive Biomarkers in Homologous Recombination-deficient Pancreatic Cancer. causal interaction,unassigned 3,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32850156&form=6&db=m Poly (ADP-Ribose) Polymerase 1 Protein Expression in Normal Pancreas and Pancreatic Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33362915&form=6&db=m Pancreatic mucinous cystadenocarcinoma in a patient harbouring BRCA1 germline mutation effectively treated with olaparib: A case report. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34309133&form=6&db=m Rapid Progression of Metastatic Pancreatic Adenocarcinoma During Platinum-Based Therapy in a Patient Harboring a Pathogenic BRCA2 Germline Variant. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34388386&form=6&db=m Talazoparib monotherapy in metastatic castration-resistant prostate cancer with DNA repair alterations (TALAPRO-1): an open-label, phase 2 trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34430059&form=6&db=m Treatment Options for Germline BRCA-Mutated Metastatic Pancreatic Adenocarcinoma. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19328833&form=6&db=m Erucin, a new promising cancer chemopreventive agent from rocket salads, shows anti-proliferative activity on human lung carcinoma A549 cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.4.2.30 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19571039&form=6&db=m Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20683914&form=6&db=m Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy. ongoing research,unassigned 1,0 2.4.2.30 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21706030&form=6&db=m Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23951099&form=6&db=m The Joint Effect of hOGG1, APE1, and ADPRT Polymorphisms and Cooking Oil Fumes on the Risk of Lung Adenocarcinoma in Chinese Non-Smoking Females. ongoing research,unassigned 2,0 2.4.2.30 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26700152&form=6&db=m Reduced tumor burden through increased oxidative stress in lung adenocarcinoma cells of PARP-1 and PARP-2 knockout mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26898760&form=6&db=m PARP1 enhances lung adenocarcinoma metastasis by novel mechanisms independent of DNA repair. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28363999&form=6&db=m ATM deficiency is associated with sensitivity to PARP1 and ATR inhibitors in lung adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.4.2.30 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31611199&form=6&db=m Poly (ADP-ribose) polymerase-1 Binding Protein Facilitates Lung Adenocarcinoma Cell Proliferation and Correlates with Poor Prognosis. causal interaction,diagnostic usage,unassigned 1,2,0 2.4.2.30 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32341333&form=6&db=m Loss of tumor suppressor inositol polyphosphate 4-phosphatase type B impairs DNA double-strand break repair by destabilization of DNA tethering protein Rad50. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33030583&form=6&db=m Targeting MALAT1 induces DNA damage and sensitize non-small cell lung cancer cells to cisplatin by repressing BRCA1. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33465722&form=6&db=m Diagnostic and therapeutic ER?, HER2, BRCA biomakers in the histological subtypes of lung adenocarcinoma according to the IASLC/ATS/ERS classification. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33468703&form=6&db=m Stenoparib, an Inhibitor of Cellular Poly(ADP-Ribose) Polymerase, Blocks Replication of the SARS-CoV-2 and HCoV-NL63 Human Coronaviruses In Vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34387603&form=6&db=m Response to olaparib in metastatic lung adenocarcinoma with germline BRCA2 mutation: a case report. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2440314&form=6&db=m Pertussis toxin inhibits somatostatin-induced K+ conductance in human pituitary tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,4 2.4.2.30 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2722137&form=6&db=m Abnormal dopamine sensitivity in some human prolactinomas. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2850725&form=6&db=m Effect of prostaglandin F2 alpha on human parathyroid adenomas: evidence for uncoupling of parathyroid hormone secretion and cAMP accumulation. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3125991&form=6&db=m Effects of cumene hydroperoxide on adenosine diphosphate ribosyl transferase in mononuclear leukocytes of patients with adenomatous polyps in the colon. causal interaction,unassigned 4,0 2.4.2.30 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9642323&form=6&db=m Some changes of receptor and postreceptor signal transduction regulated by somatostatin in pituitary hGH-secreting adenomas. ongoing research,unassigned 4,0 2.4.2.30 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824873&form=6&db=m Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane. causal interaction,unassigned 3,0 2.4.2.30 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15940627&form=6&db=m Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.4.2.30 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809031&form=6&db=m Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3 2.4.2.30 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17283177&form=6&db=m Genetic variation in base excision repair genes and the prevalence of advanced colorectal adenoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18794156&form=6&db=m Suppression of familial adenomatous polyposis by CP-31398, a TP53 modulator, in APCmin/+ mice. causal interaction,unassigned 3,0 2.4.2.30 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20107900&form=6&db=m Fish fatty acids alter markers of apoptosis in colorectal adenoma and adenocarcinoma cell lines but fish consumption has no impact on apoptosis-induction ex vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25526641&form=6&db=m PARP-1 expression is increased in colon adenoma and carcinoma and correlates with OGG1. causal interaction,diagnostic usage,unassigned 4,1,0 2.4.2.30 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9635838&form=6&db=m Absence of stimulation of poly(ADP-ribose) polymerase activity in patients predisposed to colon cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.4.2.30 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15940627&form=6&db=m Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.4.2.30 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18718511&form=6&db=m Glial reactions and degeneration of myelinated processes in spinal cord gray matter in chronic experimental autoimmune encephalomyelitis. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34144488&form=6&db=m Olaparib enhances curcumin-mediated apoptosis in oral cancer cells by inducing PARP trapping through modulation of BER and chromatin assembly. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Adenoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2437765&form=6&db=m An enzyme-linked-immunosorbent assay method for detection of immunoglobulins to pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Adrenal Cortex Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22191569&form=6&db=m Bitter Melon (Momordica charantia) Extract Suppresses Adrenocortical Cancer Cell Proliferation Through Modulation of the Apoptotic Pathway, Steroidogenesis, and Insulin-Like Growth Factor Type 1 Receptor/RAC-? Serine/Threonine-Protein Kinase Signaling. causal interaction,unassigned 2,0 2.4.2.30 Adrenal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27465581&form=6&db=m Poly(ADP-ribose) polymerase inhibition suppresses inflammation and promotes recovery from adrenal injury in a rat model of acute necrotizing pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Adrenocortical Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22555049&form=6&db=m Tempol reduces podocyte apoptosis via PARP signaling pathway in experimental diabetes mellitus. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25411384&form=6&db=m Theobromine increases NAD?/Sirt-1 activity and protects the kidney under diabetic conditions. causal interaction,unassigned 3,0 2.4.2.30 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28570002&form=6&db=m Role of poly(ADP-ribose) polymerase activation in the pathogenesis of periodontitis in diabetes. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10071053&form=6&db=m Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11861776&form=6&db=m Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2. therapeutic application,unassigned 1,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11905990&form=6&db=m Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: involvement of NO synthase via a novel pertussis toxin target. unassigned - 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16093393&form=6&db=m PolyADP-ribosylation is involved in neurotrophic activity. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16245207&form=6&db=m Alzheimer's disease related peptides affected cholinergic receptor mediated poly(ADP-ribose) polymerase activity in the hippocampus. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17084037&form=6&db=m The role of poly(ADP-ribose) polymerase-1 in CNS disease. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17290104&form=6&db=m Interaction between poly(ADP-ribose) polymerase 1 and interleukin 1A genes is associated with Alzheimer's disease risk. causal interaction,unassigned 3,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17430191&form=6&db=m Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20486200&form=6&db=m Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease. ongoing research,unassigned 2,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21616968&form=6&db=m Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22430645&form=6&db=m Poly(ADP-ribose) Polymerase-1 in Amyloid Beta Toxicity and Alzheimer's Disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23076628&form=6&db=m Activation of PARP by oxidative stress induced by ?-amyloid: implications for Alzheimer's disease. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24121118&form=6&db=m Transient OGG1, APE1, PARP1 and Pol? expression in an Alzheimer's disease mouse model. ongoing research,unassigned 2,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24151909&form=6&db=m Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in A?(1-42)-induced rat model of Alzheimer's disease. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25383391&form=6&db=m PARP1 gene variation and microglial activity on [(11)C]PBR28 PET in older adults at risk for Alzheimer's disease. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25998844&form=6&db=m Variants of Base Excision Repair Genes MUTYH , PARP1 and XRCC1 in Alzheimer's Disease Risk. therapeutic application,unassigned 1,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27034851&form=6&db=m Nucleolar PARP-1 Expression Is Decreased in Alzheimer's Disease: Consequences for Epigenetic Regulation of rDNA and Cognition. causal interaction,unassigned 3,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27567805&form=6&db=m Bioenergetic Impairment in Animal and Cellular Models of Alzheimer's Disease: PARP-1 Inhibition Rescues Metabolic Dysfunctions. causal interaction,unassigned 3,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27567859&form=6&db=m The Polyphenol Oleuropein Aglycone Modulates the PARP1-SIRT1 Interplay: An In Vitro and In Vivo Study. therapeutic application,unassigned 1,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28588086&form=6&db=m Papers of note in Science Translational Medicine 9 (392). therapeutic application,unassigned 4,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29128369&form=6&db=m Inhibition of poly(ADP-ribose) polymerase-1 alters expression of mitochondria-related genes in PC12 cells: relevance to mitochondrial homeostasis in neurodegenerative disorders. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29472838&form=6&db=m Cancer Imprints an Increased PARP-1 and p53-Dependent Resistance to Oxidative Stress on Lymphocytes of Patients That Later Develop Alzheimer's Disease. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29869722&form=6&db=m In silico identification of AChE and PARP-1 dual-targeted inhibitors of Alzheimer's disease. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30427217&form=6&db=m Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31827497&form=6&db=m Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment. causal interaction,unassigned 4,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31894029&form=6&db=m Efficacy and safety of NAD+ ADP-ribosyltransferase 1 agonist versus Donepezil in elderly Chinese patients with Alzheimer disease: A novel target for effective therapy. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33387580&form=6&db=m Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34172715&form=6&db=m Parp mutations protect from mitochondrial toxicity in Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 2.4.2.30 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34285196&form=6&db=m Correction: Parp mutations protect from mitochondrial toxicity in Alzheimer's disease. unassigned - 2.4.2.30 Amnesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9600577&form=6&db=m Effect of pertussis toxin on baclofen- and diphenhydramine-induced amnesia. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Amnesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11350863&form=6&db=m Differential prevention of morphine amnesia by antisense oligodeoxynucleotides directed against various Gi-protein alpha subunits. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Amnesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26921778&form=6&db=m Inhibition of PARP-1 participates in the mechanisms of propofol-induced amnesia in mice and human. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12528821&form=6&db=m PARP expression is increased in astrocytes but decreased in motor neurons in the spinal cord of sporadic ALS patients. causal interaction,unassigned 3,0 2.4.2.30 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15019581&form=6&db=m Reactive astrocytes express PARP in the central nervous system of SOD(G93A) transgenic mice. ongoing research,unassigned 4,0 2.4.2.30 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21215776&form=6&db=m Low levels of selenium compounds are selectively toxic for a human neuron cell line through ROS/RNS increase and apoptotic process activation. therapeutic application,unassigned 1,0 2.4.2.30 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32987654&form=6&db=m Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA. therapeutic application,unassigned 4,0 2.4.2.30 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33387580&form=6&db=m Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3309858&form=6&db=m Murine responses to immunization with pertussis toxin and bovine serum albumin: I. Mortality observed after bovine albumin challenge is due to an anaphylactic reaction. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6140011&form=6&db=m Suppression of passive cutaneous anaphylaxis by pertussis toxin, an islet-activating protein, as a result of inhibition of histamine release from mast cells. ongoing research,unassigned 3,0 2.4.2.30 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7920030&form=6&db=m Adjuvant effect of pertussis toxin on the production of anti-ovalbumin IgE in mice and lack of direct correlation between PCA and ELISA. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8744555&form=6&db=m Pertussis toxin enhanced IgG1 and IgE responses to primary tetanus immunization are mediated by interleukin-4 and persist during secondary responses to tetanus alone. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10466075&form=6&db=m Asiasari radix inhibits immunoglobulin E production on experimental models in vitro and in vivo. therapeutic application,unassigned 1,0 2.4.2.30 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10473174&form=6&db=m Inhibition of immunoglobulin E production by Poncirus trifoliata fruit extract. therapeutic application,unassigned 1,0 2.4.2.30 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11417850&form=6&db=m Disodium cromoglycate inhibits production of immunoglobulin E. therapeutic application,unassigned 1,0 2.4.2.30 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11746835&form=6&db=m Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens. therapeutic application,unassigned 1,0 2.4.2.30 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19188909&form=6&db=m Anaphylaxis to a self-peptide in the absence of mast cells or histamine. therapeutic application,unassigned 4,0 2.4.2.30 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21270409&form=6&db=m Anaphylaxis and mortality induced by treatment of mice with anti-VLA-4 antibody and pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24777913&form=6&db=m Basophil activation through ASGM1 stimulation triggers PAF release and anaphylaxis-like shock in mice. ongoing research,unassigned 1,0 2.4.2.30 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22955851&form=6&db=m Erythropoietin-driven signalling and cell migration mediated by polyADP-ribosylation. therapeutic application,unassigned 4,0 2.4.2.30 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25501596&form=6&db=m PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors. ongoing research,unassigned 2,0 2.4.2.30 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26669450&form=6&db=m PARP inhibitors in ovarian cancer: Clinical evidence for informed treatment decisions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29075104&form=6&db=m Risk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: a meta-analysis of randomized controlled trials. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33099187&form=6&db=m Therapeutic options following second-line platinum-based chemotherapy in patients with recurrent ovarian cancer: Comparison of active surveillance and maintenance treatment. causal interaction,unassigned 4,0 2.4.2.30 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33130698&form=6&db=m [Interstitial Pneumonia Caused by Olaparib during Treatment of Breast Cancer-A Case Report]. therapeutic application,unassigned 3,0 2.4.2.30 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33254040&form=6&db=m Efficacy and safety of PARP inhibitors in the treatment of advanced ovarian cancer: An updated systematic review and meta-analysis of randomized controlled trials. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33421183&form=6&db=m Haematologic toxicities with PARP inhibitors in cancer patients: an up-to-date meta-analysis of 29 randomized controlled trials. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34154315&form=6&db=m [Analysis of PARP inhibitors induced anemia in advanced and relapsed epithelial ovarian cancer]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4 2.4.2.30 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911339&form=6&db=m Clinical perspectives of PARP inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026326&form=6&db=m Pharmacological inhibition of poly(ADP-ribose) polymerase in cardiovascular disorders: future directions. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Angina, Unstable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18996291&form=6&db=m Activation and overexpression of PARP-1 in circulating mononuclear cells promote TNF-alpha and IL-6 expression in patients with unstable angina. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Angioedema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33653842&form=6&db=m Angioedema as a predominant symptom of Bordetella pertussis infection. diagnostic usage,unassigned 2,0 2.4.2.30 Angiomyolipoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22791333&form=6&db=m Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18793614&form=6&db=m cAMP imaging of cells treated with pertussis toxin, cholera toxin, and anthrax edema toxin. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19146838&form=6&db=m Caspase- and p53-dependent apoptosis in breast carcinoma cells induced by a synthetic selenadiazole derivative. ongoing research,unassigned 3,0 2.4.2.30 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22822456&form=6&db=m Monoclonal antibodies and toxins--a perspective on function and isotype. therapeutic application,unassigned 2,0 2.4.2.30 Antiphospholipid Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10524693&form=6&db=m Poly(ADP-ribose) polymerase alleles in French Caucasians are associated neither with lupus nor with primary antiphospholipid syndrome. GRAID Research Group. Group for Research on Auto-Immune Disorders. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30354818&form=6&db=m PARP-1 (Poly[ADP-Ribose] Polymerase 1) Inhibition Protects From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm in Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Aortic Valve Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22450322&form=6&db=m Increased transcript level of poly(ADP-ribose) polymerase (PARP-1) in human tricuspid compared with bicuspid aortic valves correlates with the stenosis severity. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Apnea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8119317&form=6&db=m Effect of pertussis toxin treatment on the putative adenosine A3 receptor-mediated hypotensive response in the rat. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Apnea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9806324&form=6&db=m The role of A3 adenosine receptors in central regulation of arterial blood pressure. therapeutic application,unassigned 2,0 2.4.2.30 Arrhythmias, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17646583&form=6&db=m Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy. therapeutic application,unassigned 4,0 2.4.2.30 Arrhythmias, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33110392&form=6&db=m E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7628865&form=6&db=m Modulation of inflammatory arthritis by inhibition of poly(ADP ribose) polymerase. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 2.4.2.30 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9520459&form=6&db=m Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase. causal interaction,unassigned 2,0 2.4.2.30 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11160908&form=6&db=m Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245856&form=6&db=m GPI 6150, a poly (ADP-ribose) polymerase inhibitor, exhibits an anti-inflammatory effect in rat models of inflammation. ongoing research,unassigned 2,0 2.4.2.30 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12570705&form=6&db=m Poly(ADP-ribose) polymerase inhibitors. causal interaction,unassigned 4,0 2.4.2.30 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026317&form=6&db=m Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies. causal interaction,unassigned 3,0 2.4.2.30 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16356201&form=6&db=m Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16461442&form=6&db=m Poly(ADP-ribose) polymerase (PARP) polymorphisms associated with nephritis and arthritis in systemic lupus erythematosus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16836650&form=6&db=m Essential role of neutrophils in anti-type II collagen antibody and lipopolysaccharide-induced arthritis. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17971849&form=6&db=m Therapeutic Effect of a Poly(ADP-Ribose) Polymerase-1 Inhibitor on Experimental Arthritis by Downregulating Inflammation and Th1 Response. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24845796&form=6&db=m Poly(ADP-ribose) polymerase-1 inhibitor modulates T regulatory and IL-17 cells in the prevention of adjuvant induced arthritis in mice model. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30567936&form=6&db=m Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31877876&form=6&db=m Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8728022&form=6&db=m Synergistic effects of thalidomide and poly (ADP-ribose) polymerase inhibition on type II collagen-induced arthritis in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17971849&form=6&db=m Therapeutic Effect of a Poly(ADP-Ribose) Polymerase-1 Inhibitor on Experimental Arthritis by Downregulating Inflammation and Th1 Response. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12632415&form=6&db=m A poly(ADP-ribose) polymerase haplotype spanning the promoter region confers susceptibility to rheumatoid arthritis. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15868402&form=6&db=m Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16356201&form=6&db=m Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17890271&form=6&db=m Poly(ADP-ribose) polymerase inhibition reduces tumor necrosis factor-induced inflammatory response in rheumatoid synovial fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17971849&form=6&db=m Therapeutic Effect of a Poly(ADP-Ribose) Polymerase-1 Inhibitor on Experimental Arthritis by Downregulating Inflammation and Th1 Response. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19030862&form=6&db=m The Val762Ala polymorphism in the poly(ADP-ribose) polymerase-1 gene is not associated with susceptibility in Turkish rheumatoid arthritis patients. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,4,0 2.4.2.30 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19362586&form=6&db=m PARP inhibitors: New partners in the therapy of cancer and inflammatory diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20665026&form=6&db=m Lack of association between Poly(ADP-ribose) polymerase (PARP) polymorphisms and rheumatoid arthritis in a Korean population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 2.4.2.30 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23489378&form=6&db=m Beyond dna repair,the immunological role of parp-1 and its siblings. therapeutic application,unassigned 4,0 2.4.2.30 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26339143&form=6&db=m The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27626929&form=6&db=m The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1. unassigned - 2.4.2.30 Asbestosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911336&form=6&db=m Poly(ADP-ribosyl)ation in asthma and other lung diseases. causal interaction,unassigned 4,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8752494&form=6&db=m [Involvement of G proteins between receptors and KCa channels in the regulation of airway tone by the autonomic nervous system] therapeutic application,unassigned 1,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12151309&form=6&db=m Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12594058&form=6&db=m Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14976461&form=6&db=m Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15254147&form=6&db=m Inhibition of poly(ADP-ribose) polymerase prevents allergen-induced asthma-like reaction in sensitized Guinea pigs. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911336&form=6&db=m Poly(ADP-ribosyl)ation in asthma and other lung diseases. causal interaction,unassigned 4,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19484672&form=6&db=m The Ala allele at Val762Ala polymorphism in poly(ADP-ribose) polymerase-1 (PARP-1) gene is associated with a decreased risk of asthma in a Turkish population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20715980&form=6&db=m Increased poly(ADP-ribose) polymerase (PARP)-1 expression and activity are associated with inflammation but not goblet cell metaplasia in murine models of allergen-induced airway inflammation. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21276008&form=6&db=m PARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21284655&form=6&db=m PARP-1: a new player in the asthma field? causal interaction,unassigned 2,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23184953&form=6&db=m Minocycline blocks asthma-associated inflammation in part by interfering with the T cell receptor-nuclear factor ?B-GATA-3-IL-4 axis without a prominent effect on poly(ADP-ribose) polymerase. therapeutic application,unassigned 4,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24180296&form=6&db=m Investigation of poly (ADP-ribose) polymerase-1 genetic variants as a possible risk for allergic rhinitis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24829399&form=6&db=m Silencing of poly(ADP-ribose) polymerase-1 suppresses hyperstretch-induced expression of inflammatory cytokines in vitro. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25355386&form=6&db=m Genomic Instability in Chronic Airway Inflammatory Diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25404465&form=6&db=m PARP inhibitor, olaparib ameliorates acute lung and kidney injury upon intratracheal administration of LPS in mice. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26169874&form=6&db=m PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26205779&form=6&db=m PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26339143&form=6&db=m The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27604227&form=6&db=m PARP inhibition treatment in a nonconventional experimental mouse model of chronic asthma. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28974953&form=6&db=m Poly(ADP-Ribose)Polymerase-1 in Lung Inflammatory Disorders: A Review. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29355504&form=6&db=m PARP-1 inhibition ameliorates elastase induced lung inflammation and emphysema in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29483769&form=6&db=m Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30220328&form=6&db=m The pertussis hypothesis: Bordetella pertussis colonization in the etiology of asthma and diseases of allergic sensitization. causal interaction,unassigned 2,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30964965&form=6&db=m PARP inhibition by olaparib alleviates chronic asthma-associated remodeling features via modulating inflammasome signaling in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31178661&form=6&db=m PARP-1 Is Critical for Recruitment of Dendritic Cells to the Lung in a Mouse Model of Asthma but Dispensable for Their Differentiation and Function. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31877876&form=6&db=m Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2981400&form=6&db=m Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.4.2.30 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2988509&form=6&db=m Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 2.4.2.30 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9247313&form=6&db=m The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain. therapeutic application,unassigned 1,0 2.4.2.30 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15822818&form=6&db=m Comparative status of activated ERK1/2 and PARP cleavage in human gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.4.2.30 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16607854&form=6&db=m [Functional characteristics of nucleotide-receptors in human neutrophils] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4 2.4.2.30 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19533660&form=6&db=m PARP1 expression in pediatric central nervous system tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 2.4.2.30 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20423999&form=6&db=m Inhibition of Mer and Axl Receptor Tyrosine Kinases in Astrocytoma Cells Leads to Increased Apoptosis and Improved Chemosensitivity. unassigned - 2.4.2.30 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28654422&form=6&db=m PARP1 expression and its correlation with survival is tumour molecular subtype dependent in glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.4.2.30 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34407687&form=6&db=m Tumor treating fields combined with a poly (adenosine diphosphate-ribose) polymerase inhibitor during radiotherapy for rapidly progressing IDH-wildtype diffuse astrocytoma: a case report. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Asymptomatic Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2313126&form=6&db=m Widespread silent transmission of pertussis in families: antibody correlates of infection and symptomatology. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 2.4.2.30 Asymptomatic Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10223692&form=6&db=m Cell-mediated immune responses to antigens of Bordetella pertussis and protection against pertussis in school children. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1944614&form=6&db=m Interactions of intracerebroventricular pertussis toxin treatment with the ataxic and hypothermic effects of ethanol. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9138726&form=6&db=m Mouse cerebellar adenosinergic modulation of ethanol-induced motor incoordination: possible involvement of cAMP. causal interaction,unassigned 2,0 2.4.2.30 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9581652&form=6&db=m Involvement of kappa-opioids in the mouse cerebellar adenosinergic modulation of ethanol-induced motor incoordination. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10802025&form=6&db=m Cerebellar CB(1) receptor mediation of Delta(9)-THC-induced motor incoordination and its potentiation by ethanol and modulation by the cerebellar adenosinergic A(1) receptor in the mouse. therapeutic application,unassigned 1,0 2.4.2.30 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11543952&form=6&db=m Modulation of ethanol-induced motor incoordination by mouse striatal A(1) adenosinergic receptor. unassigned - 2.4.2.30 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11867628&form=6&db=m p53 Activation by nitric oxide involves down-regulation of Mdm2. therapeutic application,unassigned 1,0 2.4.2.30 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15365299&form=6&db=m Acute ethanol-induced adenosine diphosphate ribosylation regulates the functional activity of rat striatal pertussis toxin-sensitive g proteins. unassigned - 2.4.2.30 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21840268&form=6&db=m The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest. unassigned - 2.4.2.30 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28002403&form=6&db=m XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.2.30 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33738447&form=6&db=m The promise of DNA damage response inhibitors for the treatment of glioblastoma. causal interaction,unassigned 2,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6320850&form=6&db=m Introductory review: involvement of ADP-ribosylation in cellular recovery from some forms of DNA damage. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9806612&form=6&db=m Monitoring and signaling of radiation-induced damage in mammalian cells. unassigned - 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9934867&form=6&db=m Poly(ADP-ribose) polymerase activity is not affected in ataxia telangiectasia cells and knockout mice. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12051667&form=6&db=m The inhibition of poly(ADP-ribose) polymerase enhances growth rates of ataxia telangiectasia cells. causal interaction,unassigned 4,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15204703&form=6&db=m Identification of proteins in the hamster DNA end-binding complex. diagnostic usage,unassigned 1,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17431115&form=6&db=m S-phase checkpoints regulate Apo2 ligand/TRAIL and CPT-11-induced apoptosis of prostate cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18066095&form=6&db=m Targeted cancer therapies based on the inhibition of DNA strand break repair. therapeutic application,unassigned 1,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18667510&form=6&db=m The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21917650&form=6&db=m Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival of gastric cancer. unassigned - 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22170260&form=6&db=m Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks. causal interaction,unassigned 4,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22226932&form=6&db=m Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22416035&form=6&db=m Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22483155&form=6&db=m Novel and emerging drugs for rarer chronic lymphoid leukaemias. therapeutic application,unassigned 2,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24057885&form=6&db=m Mitochondrial protein ATPase family, AAA domain containing 3A correlates with radioresistance in glioblastoma. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24550317&form=6&db=m PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24841718&form=6&db=m Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24847116&form=6&db=m Targeting poly(ADP-ribose) polymerase and the c-Myb-regulated DNA damage response pathway in castration-resistant prostate cancer. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25111287&form=6&db=m Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers? diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25337581&form=6&db=m Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26282658&form=6&db=m Randomized, Double-Blind Phase II Trial With Prospective Classification by ATM Protein Level to Evaluate the Efficacy and Tolerability of Olaparib Plus Paclitaxel in Patients With Recurrent or Metastatic Gastric Cancer. ongoing research,unassigned 2,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27613518&form=6&db=m 53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27624574&form=6&db=m PARP10 deficiency manifests by severe developmental delay and DNA repair defect. causal interaction,unassigned 4,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28481984&form=6&db=m The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28507315&form=6&db=m The Herpesvirus Nuclear Egress Complex Component, UL31, Can Be Recruited to Sites of DNA Damage Through Poly-ADP Ribose Binding. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28539367&form=6&db=m Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28789382&form=6&db=m Poly (ADP-ribose) polymerase-1 inhibition decreases proliferation through G2/M arrest in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29184090&form=6&db=m Thyroid hormones derivatives reduce proliferation and induce cell death and DNA damage in ovarian cancer. unassigned - 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29348879&form=6&db=m Loss of NEIL3 DNA glycosylase markedly increases replication associated double strand breaks and enhances sensitivity to ATR inhibitor in glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29434894&form=6&db=m Down-expression of poly(ADP-ribose) polymerase in p53-regulated pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30208292&form=6&db=m Shelterin-Mediated Telomere Protection. therapeutic application,unassigned 1,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30498082&form=6&db=m Replication Stress: An Achilles' Heel of Glioma Cancer Stem-like Cells. therapeutic application,unassigned 3,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30868056&form=6&db=m Histone deacetylase 2 is involved in DNA damage-mediated cell death of human osteosarcoma cells through stimulation of the ATM/p53 pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31449760&form=6&db=m Defining and targeting wild-type BRCA high-grade serous ovarian cancer: DNA repair and cell cycle checkpoints. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32023457&form=6&db=m A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32183301&form=6&db=m ATM-Deficient Cancers Provide New Opportunities for Precision Oncology. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32354033&form=6&db=m ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,4 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32459988&form=6&db=m Biomarker-Guided Development of DNA Repair Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33224881&form=6&db=m Predictive and Prognostic Value of DNA Damage Response Associated Kinases in Solid Tumors. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33738447&form=6&db=m The promise of DNA damage response inhibitors for the treatment of glioblastoma. causal interaction,unassigned 2,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34026622&form=6&db=m Targeting DNA Damage Repair for Immune Checkpoint Inhibition: Mechanisms and Potential Clinical Applications. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34201502&form=6&db=m Analyzing the Opportunities to Target DNA Double-Strand Breaks Repair and Replicative Stress Responses to Improve Therapeutic Index of Colorectal Cancer. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34527850&form=6&db=m Ceralasertib-Mediated ATR Inhibition Combined With Olaparib in Advanced Cancers Harboring DNA Damage Response and Repair Alterations (Olaparib Combinations). causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10559144&form=6&db=m G protein beta3 subunit 825T allele and enhanced coronary vasoconstriction on alpha(2)-adrenoceptor activation. causal interaction,unassigned 1,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12011985&form=6&db=m Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026319&form=6&db=m Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure. causal interaction,unassigned 4,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17397824&form=6&db=m Poly(ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro. causal interaction,unassigned 4,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17438151&form=6&db=m Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17919258&form=6&db=m Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18093987&form=6&db=m PARP1 is required for adhesion molecule expression in atherogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18245064&form=6&db=m Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19124646&form=6&db=m Thieno[2,3-c]isoquinolin-5-one, a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high-fat diet-fed apolipoprotein E-deficient mice: effects on inflammatory markers and lipid content. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19776495&form=6&db=m Poly (ADP-Ribose) Polymerase Inhibition Attenuates Atherosclerotic Plaque Development in ApoE-/- Mice with Hyperhomocysteinemia. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20434371&form=6&db=m Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21813379&form=6&db=m PARP inhibition in atherosclerosis and its effects on dendritic cells, T cells and auto-antibody levels. ongoing research,unassigned 4,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23027378&form=6&db=m Poly(ADP-ribose) polymerase 1 inhibition protects human aortic endothelial cells against LPS-induced inflammation response. therapeutic application,unassigned 4,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23085506&form=6&db=m Poly(ADP-ribose) polymerase 1 inhibition protects against low shear stress induced inflammation. causal interaction,unassigned 4,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24002940&form=6&db=m Poly(ADP-ribose) Polymerase 1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Implications. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25793984&form=6&db=m Low shear stress induced HMGB1 translocation and release via PECAM-1/PARP-1 pathway to induce inflammation response. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25940138&form=6&db=m Acyl-CoA-binding domain containing 3 modulates NAD+ metabolism through activating poly(ADP-ribose) polymerase 1. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26339143&form=6&db=m The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27026705&form=6&db=m PARP-1 Represses LXR-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27757983&form=6&db=m Poly(ADP-ribose) polymerase 1 deficiency increases nitric oxide production and attenuates aortic atherogenesis through downregulation of arginase II. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29968072&form=6&db=m Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30158868&form=6&db=m Poly (ADP-Ribose) Polymerase 1 Mediated Arginase II Activation Is Responsible for Oxidized LDL-Induced Endothelial Dysfunction. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30394268&form=6&db=m PARP-1 Involvement in Autophagy and Their Roles in Apoptosis of Vascular Smooth Muscle Cells under Oxidative Stress. causal interaction,unassigned 4,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31276434&form=6&db=m PJ34, a PARP1 inhibitor, promotes endothelial repair in a rabbit model of high fat diet-induced atherosclerosis. ongoing research,unassigned 1,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31877876&form=6&db=m Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32981917&form=6&db=m Phenotypic Switching of Atherosclerotic Smooth Muscle Cells is Regulated by Activated PARP1-Dependent TET1 Expression. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33110392&form=6&db=m E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34450194&form=6&db=m PARPs in lipid metabolism and related diseases. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30898999&form=6&db=m DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation. therapeutic application,unassigned 1,0 2.4.2.30 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34445832&form=6&db=m [The epidemiological characteristics and adherence to hypoglycemic agents of ischemic stroke patients with diabetes]. causal interaction,unassigned 2,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1347051&form=6&db=m Pertussis toxin-induced lymphocytosis is associated with alterations in thymocyte subpopulations. ongoing research,unassigned 2,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8095458&form=6&db=m Protection against autoimmune disease by bacterial agents. II. PPD and pertussis toxin as proteins active in protecting mice against experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8400894&form=6&db=m Lymphocyte proliferation induced by pertussis toxin utilizes a pathway parallel to transforming growth factor-beta-sensitive growth. therapeutic application,unassigned 3,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8475118&form=6&db=m Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6. causal interaction,unassigned 2,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9069580&form=6&db=m Immunomodulation of murine experimental autoimmune encephalomyelitis by pertussis toxin: the protective activity, but not the disease-enhancing activity, can be attributed to the nontoxic B-oligomer. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9645613&form=6&db=m Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28. therapeutic application,unassigned 2,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10683510&form=6&db=m Analysis of experimental autoimmune encephalomyelitis induced in F344 rats by pertussis toxin administration. causal interaction,ongoing research,unassigned 2,2,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10706738&form=6&db=m Genetic analysis of the influence of pertussis toxin on experimental allergic encephalomyelitis susceptibility: an environmental agent can override genetic checkpoints. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,3,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11418656&form=6&db=m Pertussis toxin inhibits induction of tissue-specific autoimmune disease by disrupting G protein-coupled signals. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11445281&form=6&db=m Pertussis toxin-induced hyperacute autoimmune encephalomyelitis in Lewis rats is correlated with increased expression of inducible nitric oxide synthase and tumor necrosis factor alpha. causal interaction,unassigned 4,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12161029&form=6&db=m Pertussis toxin alters the innate and the adaptive immune responses in a pertussis-dependent model of autoimmunity. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12506112&form=6&db=m Apoptosis in leukemia cells is accompanied by alterations in the levels and localization of nucleolin. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12574336&form=6&db=m Pertussis toxin enhances Th1 responses by stimulation of dendritic cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12928376&form=6&db=m Dissociating the enhancing and inhibitory effects of pertussis toxin on autoimmune disease. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15868402&form=6&db=m Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911334&form=6&db=m Roles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16849462&form=6&db=m Pertussis toxin reduces the number of splenic Foxp3+ regulatory T cells. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17430113&form=6&db=m Pharmacological targeting of IDO-mediated tolerance for treating autoimmune disease. causal interaction,unassigned 3,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19372636&form=6&db=m Autoantibodies to Poly(ADP-Ribose) Polymerase in Centenarians: A Reappraisal of Grabar's Hypothesis. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20544540&form=6&db=m PARP activity and NAD concentration in PMC from patients affected by systemic sclerosis and lupus erythematosus. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20700542&form=6&db=m Paradoxical effect of pertussis toxin on the delayed hypersensitivity response to autoantigens in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21209857&form=6&db=m Repetitive pertussis toxin promotes development of regulatory T cells and prevents central nervous system autoimmune disease. causal interaction,unassigned 2,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21476963&form=6&db=m Poly (ADP-Ribose) Polymerase-1 (PARP-1) as Immune Regulator. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24371118&form=6&db=m Histamine H2 receptor signaling x environment interactions determine susceptibility to experimental allergic encephalomyelitis. ongoing research,unassigned 4,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26080611&form=6&db=m The Role of PARP-1 in Host-Pathogen Interaction and Cellular Stress Responses. therapeutic application,unassigned 1,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26429911&form=6&db=m Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26912654&form=6&db=m Transcriptional reprogramming and resistance to colonic mucosal injury in Poly(ADP-ribose) polymerase 1 (PARP1)-deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Azoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22467112&form=6&db=m An ADP-ribosyltransferase 3 (ART3) variant is associated with reduced sperm counts in Czech males: case/control association study replicating results from the Japanese population. causal interaction,unassigned 2,0 2.4.2.30 Azoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26221352&form=6&db=m Association of polymorphisms in ART3 gene with male infertility in the Chinese population. unassigned - 2.4.2.30 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20435926&form=6&db=m Monocyte Trafficking to Hepatic Sites of Bacterial Infection Is Chemokine Independent and Directed by Focal Intercellular Adhesion Molecule-1 Expression. therapeutic application,unassigned 1,0 2.4.2.30 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31207286&form=6&db=m Host poly(ADP-ribose) polymerases (PARPs) in acute and chronic bacterial infections. therapeutic application,unassigned 4,0 2.4.2.30 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23757351&form=6&db=m MicroRNA 223 is upregulated in the multistep progression of Barrett's esophagus and modulates sensitivity to chemotherapy by targeting PARP1. therapeutic application,unassigned 2,0 2.4.2.30 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29531462&form=6&db=m Dysregulation of PARP1 is involved in development of Barrett's esophagus. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Bicuspid Aortic Valve Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22450322&form=6&db=m Increased transcript level of poly(ADP-ribose) polymerase (PARP-1) in human tricuspid compared with bicuspid aortic valves correlates with the stenosis severity. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Biliary Tract Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32075397&form=6&db=m Biliary tract cancer and genomic alterations in homologous recombinant deficiency: exploiting synthetic lethality with PARP inhibitors. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Biliary Tract Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32878011&form=6&db=m PARP Inhibitors in Biliary Tract Cancer: A New Kid on the Block? therapeutic application,unassigned 3,0 2.4.2.30 Biliary Tract Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33660569&form=6&db=m Investigational PARP inhibitors for the treatment of biliary tract cancer: spotlight on preclinical and clinical studies. therapeutic application,unassigned 4,0 2.4.2.30 Biliary Tract Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34352995&form=6&db=m Inhibition of WEE1 Potentiates Sensitivity to PARP Inhibitor in Biliary Tract Cancer. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2872098&form=6&db=m Cell surface antigens of Bordetella pertussis. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8022314&form=6&db=m Two phases of pseudopod protrusion in tumor cells revealed by a micropipette. unassigned - 2.4.2.30 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10101095&form=6&db=m Activation of poly [ADP-Ribose] polymerase in endothelial cells and keratinocytes: role in an in vitro model of sulfur mustard-mediated vesication. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10411106&form=6&db=m Involvement of small GTPases Rho and Rac in the invasion of rat ascites hepatoma cells. causal interaction,unassigned 3,0 2.4.2.30 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11886524&form=6&db=m PARP determines the mode of cell death in skin fibroblasts, but not keratinocytes, exposed to sulfur mustard. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12794939&form=6&db=m Putative role of proteolysis and inflammatory response in the toxicity of nerve and blister chemical warfare agents: implications for multi-threat medical countermeasures. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26184150&form=6&db=m Neolignans from Nectandra megapotamica (Lauraceae) Display in vitro Cytotoxic Activity and Induce Apoptosis in Leukemia Cells. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33535591&form=6&db=m The SC-35 Splicing Factor Interacts with RNA Pol II and A-Type Lamin Depletion Weakens This Interaction. unassigned - 2.4.2.30 Bloom Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15204703&form=6&db=m Identification of proteins in the hamster DNA end-binding complex. diagnostic usage,unassigned 1,0 2.4.2.30 Bloom Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32697083&form=6&db=m Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors. therapeutic application,unassigned 3,0 2.4.2.30 Bone Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23435312&form=6&db=m NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity. therapeutic application,unassigned 4,0 2.4.2.30 Bone Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23521814&form=6&db=m Spinal RhoA/Rho Kinase Signaling Pathway may Participate in the Development of Bone Cancer Pain. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1653845&form=6&db=m Pertussis toxin inhibits hormonal stimulation of bone resorption in fetal rat limb bones. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2539969&form=6&db=m Effects of pertussis toxin on resorption of 19-day-old fetal rat long bones. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2823535&form=6&db=m Inhibitory action of pertussis toxin on parathyroid hormone and prostaglandin E2-stimulated bone resorption in cultured neonatal mouse calvaria. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7673348&form=6&db=m The small GTP-binding protein, rho p21, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts. ongoing research,unassigned 4,0 2.4.2.30 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8427592&form=6&db=m Stimulation of a Gs-like G protein in the osteoclast inhibits bone resorption but enhances tartrate-resistant acid phosphatase secretion. therapeutic application,unassigned 4,0 2.4.2.30 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10766830&form=6&db=m Rho-A is critical for osteoclast podosome organization, motility, and bone resorption. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14630900&form=6&db=m Role of the activation of the nuclear enzyme poly(ADP-ribose) polymerase in the pathogenesis of periodontitis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Bordetella Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2622329&form=6&db=m Bordetella adenylate cyclase is a virulence associated factor and an immunoprotective antigen. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Bordetella Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8223658&form=6&db=m Western blot analysis of antibody responses of young infants to pertussis infection. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Bordetella Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10618063&form=6&db=m Polymorphism in the pertussis toxin promoter region affecting the DNA-based diagnosis of Bordetella infection. causal interaction,diagnostic usage,unassigned 2,3,0 2.4.2.30 Bradycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1963570&form=6&db=m Mechanism of the cardiovascular effects of GABAB receptor activation in the nucleus tractus solitarii of the rat. ongoing research,unassigned 3,0 2.4.2.30 Bradycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8119317&form=6&db=m Effect of pertussis toxin treatment on the putative adenosine A3 receptor-mediated hypotensive response in the rat. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Bradycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8324794&form=6&db=m Preconditioning against infarction in the rat heart does not involve a pertussis toxin sensitive G protein. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,3 2.4.2.30 Bradycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9316844&form=6&db=m Differentiation of muscarinic receptors mediating negative chronotropic and vasoconstrictor responses to acetylcholine in isolated rat hearts. therapeutic application,unassigned 2,0 2.4.2.30 Bradycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10699641&form=6&db=m Enhanced negative chronotropy by inhibitory receptors in transgenic heart overexpressing beta(2)-adrenoceptors. therapeutic application,unassigned 1,0 2.4.2.30 Bradycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12637351&form=6&db=m Altered sinus nodal and atrioventricular nodal function in freely moving mice overexpressing the A1 adenosine receptor. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Brain Death http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18475194&form=6&db=m Activation and modulation of cardiac poly-adenosine diphosphate ribose polymerase activity in a rat model of brain death. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2867545&form=6&db=m Pertussis toxin is required for pertussis vaccine encephalopathy. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,3,0 2.4.2.30 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2872126&form=6&db=m Murine model for pertussis vaccine encephalopathy: role of the major histocompatibility complex; antibody to albumin and to Bordetella pertussis and pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9755273&form=6&db=m Pertussis encephalopathy with high cerebrospinal fluid antibody titers to pertussis toxin and filamentous hemagglutinin. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12486156&form=6&db=m Pertussis toxin-induced reversible encephalopathy dependent on monocyte chemoattractant protein-1 overexpression in mice. unassigned - 2.4.2.30 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12557009&form=6&db=m Apoptosis and microglial activation in influenza encephalopathy. unassigned - 2.4.2.30 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15207836&form=6&db=m Poly(ADP-ribosyl)ation enhancement in brain cell nuclei is associated with diabetic neuropathy. causal interaction,unassigned 1,0 2.4.2.30 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17082642&form=6&db=m Metalloproteinases control brain inflammation induced by pertussis toxin in mice overexpressing the chemokine CCL2 in the central nervous system. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24935635&form=6&db=m PARP inhibition delays progression of mitochondrial encephalopathy in mice. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32209694&form=6&db=m Bordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses CaV3.1 as the Cell Surface Receptor. causal interaction,unassigned 3,0 2.4.2.30 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12663936&form=6&db=m Poly(ADP-ribose) polymerase during reperfusion after transient forebrain ischemia: its role in brain edema and cell death. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17213862&form=6&db=m Contribution of poly(ADP-ribose) polymerase to postischemic blood-brain barrier damage in rats. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19066076&form=6&db=m Poly(ADP-ribose) polymerase activation and brain edema formation by hemoglobin after intracerebral hemorrhage in rats. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Brain Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10736067&form=6&db=m Neuronal death in brain infarcts in man. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.4.2.30 Brain Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12628750&form=6&db=m Poly(ADP-ribose) polymerase as a key player in excitotoxicity and post-ischemic brain damage. therapeutic application,unassigned 4,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9334709&form=6&db=m At the scene of ischemic brain injury: is PARP a perp? causal interaction,unassigned 2,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9390645&form=6&db=m Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9989452&form=6&db=m Oxidative stress in bacterial meningitis. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10205784&form=6&db=m [Involvement of caspase on apoptosis in ischemia-induced neuronal cell death: usefulness of caspase inhibitors for stroke therapy] causal interaction,unassigned 4,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10386972&form=6&db=m Temporal patterns of poly(ADP-ribose) polymerase activation in the cortex following experimental brain injury in the rat. ongoing research,unassigned 2,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11039724&form=6&db=m Effects of transient global ischemia and kainate on poly(ADP-ribose) polymerase (PARP) gene expression and proteolytic cleavage in gerbil and rat brains. therapeutic application,unassigned 1,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11095782&form=6&db=m Acute Meningitis. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179503&form=6&db=m Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12441748&form=6&db=m Drug-induced hypothermia begun 5 minutes after injury with a poly(adenosine 5'-diphosphate-ribose) polymerase inhibitor reduces hypoxic brain injury in rat pups. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14580948&form=6&db=m Inhibition of neuronal nitric oxide synthase-mediated activation of poly(ADP-ribose) polymerase in traumatic brain injury: neuroprotection by 3-aminobenzamide. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075382&form=6&db=m A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15312162&form=6&db=m PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15514191&form=6&db=m Interaction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911330&form=6&db=m Poly(ADP-ribosyl)ation and stroke. causal interaction,unassigned 1,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16202986&form=6&db=m Neuroprotective effects of KCL-440, a new poly(ADP-ribose) polymerase inhibitor, in the rat middle cerebral artery occlusion model. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16209916&form=6&db=m Biphasic changes in the levels of poly(ADP-ribose) polymerase-1 and caspase 3 in the immature brain following hypoxia-ischemia. ongoing research,unassigned 2,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16627622&form=6&db=m Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. unassigned - 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17213862&form=6&db=m Contribution of poly(ADP-ribose) polymerase to postischemic blood-brain barrier damage in rats. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17455321&form=6&db=m Enhanced poly(ADP-ribose) polymerase-1 activation contributes to recombinant tissue plasminogen activator-induced aggravation of ischemic brain injury in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17711401&form=6&db=m Local administration of the poly(ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17966294&form=6&db=m Poly(ADP-ribose) polymerase-1 and its clinical applications in brain injury. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17981619&form=6&db=m NAD+ and NADH in ischemic brain injury. causal interaction,unassigned 4,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19268668&form=6&db=m Sex differences in the response to activation of the poly (ADP-ribose) polymerase pathway after experimental stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19687776&form=6&db=m Postnatal Age Influences Hypoglycemia-induced Poly(ADP-ribose) Polymerase-1 Activation in the Brain Regions of Rats. causal interaction,ongoing research,unassigned 2,4,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19925161&form=6&db=m Influence of PARP-1 polymorphisms in patients after traumatic brain injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20423305&form=6&db=m Oxidative Stress and NAD(+) in Ischemic Brain Injury: Current Advances and Future Perspectives. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20480019&form=6&db=m A novel PARP inhibitor L-2286 in a rat model of impact acceleration head injury: An immunohistochemical and behavioral study. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22204321&form=6&db=m NAD+ Metabolism and NAD+-Dependent Enzymes: Promising Therapeutic Targets for Neurological Diseases. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24386592&form=6&db=m Roles of NAD (+) , PARP-1, and Sirtuins in Cell Death, Ischemic Brain Injury, and Synchrotron Radiation X-Ray-Induced Tissue Injury. causal interaction,ongoing research,unassigned 3,1,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27157545&form=6&db=m PARP inhibition attenuates early brain injury through NF-?B/MMP-9 pathway in a rat model of subarachnoid hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27444121&form=6&db=m Microglial activation induced by the alarmin S100B is regulated by poly(ADP-ribose) polymerase-1. therapeutic application,unassigned 1,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27663279&form=6&db=m Poly(ADP-ribose) polymerase is not involved in the neuroprotection exerted by azithromycin against ischemic stroke in mice. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28370165&form=6&db=m Neuroprotective effects of a novel Poly (ADP-Ribose) Polymerase-1 inhibitor, JPI-289, in hypoxic rat cortical neurons. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28698869&form=6&db=m Effects of Poly(ADP-Ribose) Polymerase-1 Inhibition in a Neonatal Rodent Model of Hypoxic-Ischemic Injury. causal interaction,unassigned 1,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29760953&form=6&db=m Hyperglycemia potentiates a shift from apoptosis to RIP1-dependent necroptosis. unassigned - 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32030092&form=6&db=m Effect of 3-Aminobenzamide on the Ultrastructure of Astrocytes and Microvessels After Focal Cerebral Ischemia in Rats. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32380185&form=6&db=m Nicotinamide mononucleotide administration after sever hypoglycemia improves neuronal survival and cognitive function in rats. causal interaction,unassigned 1,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9987014&form=6&db=m Poly(ADP ribose) polymerase cleavage precedes neuronal death in the hippocampus and cerebellum following injury to the developing rat forebrain. unassigned - 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10458590&form=6&db=m Reduction of cognitive and motor deficits after traumatic brain injury in mice deficient in poly(ADP-ribose) polymerase. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11160908&form=6&db=m Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11336438&form=6&db=m Pharmacologic inhibition of poly(ADP-ribose) polymerase is neuroprotective following traumatic brain injury in rats. therapeutic application,unassigned 3,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11450092&form=6&db=m Traumatic brain injury in mice deficient in poly-ADP(ribose) polymerase: a preliminary report. causal interaction,unassigned 3,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11501263&form=6&db=m [Neuronal death: potential role of the nuclear enzyme, poly (ADP-ribose) polymerase] causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11526433&form=6&db=m Increased expression and activation of poly(ADP-ribose) polymerase (PARP) contribute to retinal ganglion cell death following rat optic nerve transection. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12694396&form=6&db=m A dual role for poly-ADP-ribosylation in spatial memory acquisition after traumatic brain injury in mice involving NAD+ depletion and ribosylation of 14-3-3gamma. therapeutic application,unassigned 1,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12851710&form=6&db=m PARP inhibition improves the effectiveness of neural stem cell transplantation in experimental brain trauma. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14580948&form=6&db=m Inhibition of neuronal nitric oxide synthase-mediated activation of poly(ADP-ribose) polymerase in traumatic brain injury: neuroprotection by 3-aminobenzamide. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15829224&form=6&db=m Beneficial effects of PJ34 and INO-1001, two novel water-soluble poly(ADP-ribose) polymerase inhibitors, on the consequences of traumatic brain injury in rat. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17711401&form=6&db=m Local administration of the poly(ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17996029&form=6&db=m Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19925161&form=6&db=m Influence of PARP-1 polymorphisms in patients after traumatic brain injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20380552&form=6&db=m Effect of Acute Poly(ADP-Ribose) Polymerase Inhibition by 3-AB on Blood-Brain Barrier Permeability and Edema Formation After Focal Traumatic Brain Injury in Rats. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22037978&form=6&db=m The expression pattern of ADP-ribosyltransferase 3 in rat traumatic brain injury. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22335939&form=6&db=m Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24476502&form=6&db=m PARP-1 Inhibition Attenuates Neuronal Loss, Microglia Activation and Neurological Deficits after Traumatic Brain Injury. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25668593&form=6&db=m Protective actions of PJ34, a poly(ADP-ribose)polymerase inhibitor, on the blood-brain barrier after traumatic brain injury in mice. causal interaction,unassigned 1,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25924998&form=6&db=m Poly(ADP-Ribose)Polymerase 1 (PARP-1) Activation and Ca(2+) Permeable ?-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Channels in Post-Ischemic Brain Damage: New Therapeutic Opportunities? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25940138&form=6&db=m Acyl-CoA-binding domain containing 3 modulates NAD+ metabolism through activating poly(ADP-ribose) polymerase 1. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26709902&form=6&db=m Alternative mechanisms of inhibiting activity of poly (ADP-ribose) polymerase-1. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27119554&form=6&db=m Protective effects of PARP inhibitor, PJ34, is related to down-regulation of calpain and NF-?B in a mouse model of TBI. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28642177&form=6&db=m Protective functions of PJ34, a PARP inhibitor, is related to down-regulation of calpain and NF-?B in a mouse model of TBI. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32030092&form=6&db=m Effect of 3-Aminobenzamide on the Ultrastructure of Astrocytes and Microvessels After Focal Cerebral Ischemia in Rats. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32337957&form=6&db=m PARP1 might enhance the therapeutic effect of tetrahydroxystilbene glucoside in traumatic brain injury via inhibition of Ras/JNK signalling pathway. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1898506&form=6&db=m Ischemia of rat brain decreases pertussis toxin-catalyzed [32P]ADP ribosylation of GTP-binding proteins (Gi1 and G0) in membranes. diagnostic usage,unassigned 1,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9334719&form=6&db=m Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9550519&form=6&db=m Inhibition of poly(ADP-ribose) polymerase: reduction of ischemic injury and attenuation of N-methyl-D-aspartate-induced neurotransmitter dysregulation. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9740102&form=6&db=m Enhanced poly(ADP-ribosyl)ation after focal ischemia in rat brain. ongoing research,unassigned 4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9989455&form=6&db=m Oxidative stress in brain ischemia. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10350529&form=6&db=m Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10374629&form=6&db=m Neuroprotective effects of poly (ADP-ribose) polymerase inhibitors in transient focal cerebral ischemia of rats. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10424667&form=6&db=m The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10771174&form=6&db=m The neuroprotective effect of cerebral poly(ADP-ribose)polymerase inhibition in a rat model of global ischemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11050121&form=6&db=m NMDA but not non-NMDA excitotoxicity is mediated by Poly(ADP-ribose) polymerase. causal interaction,unassigned 4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179503&form=6&db=m Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11501263&form=6&db=m [Neuronal death: potential role of the nuclear enzyme, poly (ADP-ribose) polymerase] causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11526447&form=6&db=m Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12045668&form=6&db=m Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors. therapeutic application,unassigned 4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12606624&form=6&db=m Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12750003&form=6&db=m Role of superoxide in poly(ADP-ribose) polymerase upregulation after transient cerebral ischemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,4 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13679179&form=6&db=m Towards new neuroprotective agents: design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors. therapeutic application,unassigned 4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14767566&form=6&db=m Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14769390&form=6&db=m 3-Aminobenzamide reduces brain infarction and neutrophil infiltration after transient focal cerebral ischemia in mice. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075382&form=6&db=m A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15306164&form=6&db=m Inhibition of poly (ADP-ribose) polymerase and caspase-3, but not caspase-1, prevents apoptosis and improves spatial memory of rats with twice-repeated cerebral ischemia. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466246&form=6&db=m A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15514191&form=6&db=m Interaction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15689952&form=6&db=m Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection. causal interaction,unassigned 4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15868400&form=6&db=m Pathophysiologic role of oxidative stress-induced poly(ADP-ribose) polymerase-1 activation: focus on cell death and transcriptional regulation. unassigned - 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911330&form=6&db=m Poly(ADP-ribosyl)ation and stroke. causal interaction,unassigned 1,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16085349&form=6&db=m Effect of 3-aminobenzamide, PARP inhibitor, on matrix metalloproteinase-9 level in plasma and brain of ischemic stroke model. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16150058&form=6&db=m Mitochondrial impairment induced by poly(ADP-ribose) polymerase-1 activation in cortical neurons after oxygen and glucose deprivation. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16181422&form=6&db=m Mitochondrial impairment induced by poly(ADP-ribose) polymerase-1 activation in cortical neurons after oxygen and glucose deprivation. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16267234&form=6&db=m Apoptosis-inducing factor triggered by poly(ADP-Ribose) polymerase and bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. therapeutic application,unassigned 2,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16865091&form=6&db=m Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16892389&form=6&db=m Poly(ADP-Ribose)-Polymerase-Catalyzed Hydrolysis of NAD(+): QM/MM Simulation of the Enzyme Reaction. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16935310&form=6&db=m Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17455321&form=6&db=m Enhanced poly(ADP-ribose) polymerase-1 activation contributes to recombinant tissue plasminogen activator-induced aggravation of ischemic brain injury in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640816&form=6&db=m SPATIAL AND FUNCTIONAL RELATIONSHIP BETWEEN POLY(ADP-RIBOSE) POLYMERASE-1 AND POLY(ADP-RIBOSE) GLYCOHYDROLASE IN THE BRAIN. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18032109&form=6&db=m Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage. therapeutic application,unassigned 3,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18468597&form=6&db=m Reduction of hemorrhagic transformation by PJ34, a poly(ADP-ribose)polymerase inhibitor, after permanent focal cerebral ischemia in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18617666&form=6&db=m Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: role of enhanced DNA repair. causal interaction,unassigned 2,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19225880&form=6&db=m Differential PARP Cleavage: An Indication of Heterogeneous Forms of Cell Death and Involvement of Multiple Proteases in the Infarct of Focal Cerebral Ischemia in Rat. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19268668&form=6&db=m Sex differences in the response to activation of the poly (ADP-ribose) polymerase pathway after experimental stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20035840&form=6&db=m Poly (ADP-ribose) polymerase-1 initiated neuronal cell death pathway--do androgens matter? ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20236222&form=6&db=m Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20423305&form=6&db=m Oxidative Stress and NAD(+) in Ischemic Brain Injury: Current Advances and Future Perspectives. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21151457&form=6&db=m Neuroprotective Properties of Picroside II in a Rat Model of Focal Cerebral Ischemia. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21176168&form=6&db=m PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21420942&form=6&db=m Neuroprotective effects of a novel water-soluble poly(ADP-ribose) polymerase-1 inhibitor, MP-124, in in vitro and in vivo models of cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22436003&form=6&db=m Combined therapy with PJ34, a poly(ADP-ribose)polymerase inhibitor, reduces tissue plasminogen activator-induced hemorrhagic transformations in cerebral ischemia in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22476980&form=6&db=m Natural Inhibitors of Poly(ADP-ribose) Polymerase-1. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23463404&form=6&db=m Ginsenoside Rd blocks AIF mitochondrio-nuclear translocation and NF-?B nuclear accumulation by inhibiting poly(ADP-ribose) polymerase-1 after focal cerebral ischemia in rats. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23816753&form=6&db=m Neuropilin-1 modulates vascular endothelial growth factor-induced poly(ADP-ribose)-polymerase leading to reduced cerebrovascular apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25277843&form=6&db=m Role of continuous high thoracic epidural anesthesia in hippocampal apoptosis after global cerebral ischemia in rats. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25329809&form=6&db=m Another "string to the bow" of PJ34, a potent poly(ADP-Ribose)polymerase inhibitor: an antiplatelet effect through P2Y12 antagonism? causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25446913&form=6&db=m Neuroprotection by the PARP inhibitor PJ34 modulates cerebral and circulating RAGE levels in rats exposed to focal brain ischemia. therapeutic application,unassigned 2,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26220474&form=6&db=m Protection of the brain following cerebral ischemia through the attenuation of PARP-1-induced neurovascular unit damage in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27381826&form=6&db=m Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28007581&form=6&db=m Different doses of dexmedetomidine reduce plasma cytokine production, brain oxidative injury, PARP and caspase expression levels but increase liver oxidative toxicity in cerebral ischemia-induced rats. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28095779&form=6&db=m Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29651748&form=6&db=m Improved Reperfusion and Vasculoprotection by the Poly(ADP-Ribose)Polymerase Inhibitor PJ34 After Stroke and Thrombolysis in Mice. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32224555&form=6&db=m Epigallocatechin gallate alleviates neuronal cell damage against focal cerebral ischemia in rats. therapeutic application,unassigned 3,0 2.4.2.30 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32676009&form=6&db=m Pertussis Toxin Ameliorates Microglial Activation Associated With Ischemic Stroke. causal interaction,ongoing research,unassigned 4,3,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9616774&form=6&db=m Whole-body hyperthermia and ADPRT inhibition in experimental treatment of brain tumors. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11359911&form=6&db=m DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12507917&form=6&db=m Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice. ongoing research,unassigned 2,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15645126&form=6&db=m Brain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911331&form=6&db=m Chemopotentiation by PARP inhibitors in cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19208614&form=6&db=m The potential role and application of PARP inhibitors in cancer treatment. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22184287&form=6&db=m PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22268386&form=6&db=m Targeted Therapy for Brain Tumours: Role of PARP Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24625110&form=6&db=m A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity. therapeutic application,unassigned 2,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24908656&form=6&db=m A phase I trial of veliparib (ABT-888) and temozolomide in children with recurrent CNS tumors: a Pediatric Brain Tumor Consortium report† ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25911198&form=6&db=m Association Between PARP1 Single Nucleotide Polymorphism and Brain Tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26493053&form=6&db=m Non-invasive PET Imaging of PARP1 Expression in Glioblastoma Models. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27409836&form=6&db=m Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28099939&form=6&db=m Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,4,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28376211&form=6&db=m Rad51 Degradation: Role in Oncolytic Virus-Poly(ADP-Ribose) Polymerase Inhibitor Combination Therapy in Glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29917049&form=6&db=m Breast cancer brain metastases show increased levels of genomic aberration-based homologous recombination deficiency scores relative to their corresponding primary tumors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32652442&form=6&db=m Pamiparib is a potent and selective PARP inhibitor with unique potential for the treatment of brain tumor. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33376347&form=6&db=m Niraparib as Maintenance Therapy in Germline ATM-mutated and Somatic BRCA2-mutated Ovarian Cancer with Brain Metastases: A Case Report and Literature Review. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33384227&form=6&db=m Targeted Therapies for Breast Cancer Brain Metastases. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33392502&form=6&db=m Preclinical and first-in-human-brain-cancer applications of [18F]poly (ADP-ribose) polymerase inhibitor PET/MR. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33545804&form=6&db=m Successful treatment of a patient with brain metastases from endometrial cancer using Niraparib: a case report. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34069106&form=6&db=m Transferrin Modified GSH Sensitive Hyaluronic Acid Derivative Micelle to Deliver HSP90 Inhibitors to Enhance the Therapeutic Efficacy of Brain Cancers. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Breast Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9295059&form=6&db=m Poly(ADP-ribose) polymerase in human breast cancer: a case-control analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2121341&form=6&db=m Oxidative stress, DNA repair, and cancer susceptibility. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3126185&form=6&db=m G-protein-mediated epidermal growth factor signal transduction in a human breast cancer cell line. Evidence for two intracellular pathways distinguishable by pertussis toxin. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6097215&form=6&db=m Effects of pertussis toxin on adenylate cyclase responses to prostaglandin E2 and calcitonin in human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7935983&form=6&db=m 3-Aminobenzamide delays rejoining of DNA strand breaks in gamma-irradiated lymphocytes from patients with breast cancer and not cervical cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9295059&form=6&db=m Poly(ADP-ribose) polymerase in human breast cancer: a case-control analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9393748&form=6&db=m Galectin-3: a novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9751635&form=6&db=m Interleukin 4 inhibits growth and induces apoptosis in human breast cancer cells. causal interaction,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9816283&form=6&db=m Poly(ADP-ribose) polymerase gene expression status and genomic instability in human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10217178&form=6&db=m Detection of heterogeneity of apoptotic fragments of poly (ADP-ribose) polymerase in MDA-MB-468 breast cancer cells: two-dimensional gel analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10400681&form=6&db=m Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences. ongoing research,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10597252&form=6&db=m VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth. ongoing research,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10780527&form=6&db=m Bisphosphonates induce apoptosis in human breast cancer cell lines. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10813395&form=6&db=m Caught in the act: binding of Ku and PARP to MARs reveals novel aspects of their functional interaction. causal interaction,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11085519&form=6&db=m Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11571297&form=6&db=m Hepatocyte growth factor/scatter factor blocks the mitochondrial pathway of apoptosis signaling in breast cancer cells. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12183419&form=6&db=m A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14973060&form=6&db=m The tumor invasion inhibitor dihydromotuporamine C activates RHO, remodels stress fibers and focal adhesions, and stimulates sodium-proton exchange. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15145516&form=6&db=m Differential inhibition of fatty acid transport in tissue-isolated steroid receptor negative human breast cancer xenografts perfused in situ with isomers of conjugated linoleic acid. therapeutic application,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15456408&form=6&db=m PARP inhibition sensitizes p53-deficient breast cancer cells to doxorubicin-induced apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15720130&form=6&db=m Induction of cytotoxicity, aldehydic DNA lesions, and poly(ADP-ribose) polymerase-1 activation by catechol derivatives of pentachlorophenol in calf thymus DNA and in human breast cancer cells. ongoing research,unassigned 2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15952054&form=6&db=m Gene 33 inhibits apoptosis of breast cancer cells and increases poly(ADP-ribose) polymerase expression. ongoing research,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16251802&form=6&db=m BRCA2-Deficient CAPAN-1 Cells are Extremely Sensitive to the Inhibition of Poly (ADP-Ribose) Polymerase: An Issue of Potency. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16328064&form=6&db=m Polymorphisms of ADPRT Val762Ala and XRCC1 Arg399Glu and risk of breast cancer in Chinese women: a case control analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16412983&form=6&db=m Suppression of survival in human SKBR3 breast carcinoma in response to metal-chelator complexes is preferential for copper-dithiocarbamate. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16492928&form=6&db=m Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16810332&form=6&db=m The Inhibition and Treatment of Breast Cancer with Poly (ADP-ribose) Polymerase (PARP-1) Inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16820891&form=6&db=m Cell-cycle progression and response of germ cell tumors to cisplatin in vitro. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16827122&form=6&db=m PARP regulates TGF-beta receptor type II expression in estrogen receptor-positive breast cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16884709&form=6&db=m Induction of ROS formation, poly(ADP-ribose) polymerase-1 activation, and cell death by PCB126 and PCB153 in human T47D and MDA-MB-231 breast cancer cells. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16906222&form=6&db=m PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers? causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16912188&form=6&db=m Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17160013&form=6&db=m Poly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17214747&form=6&db=m Evidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17224139&form=6&db=m Disparity in the induction of glutathione depletion, ROS formation, poly(ADP-ribose) polymerase-1 activation, and apoptosis by quinonoid derivatives of naphthalene in human cultured cells. ongoing research,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17318223&form=6&db=m Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17339367&form=6&db=m Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17554206&form=6&db=m Resveratrol-induced growth inhibition in MDA-MB-231 breast cancer cells is associated with mitogen-activated protein kinase signaling and protein translation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17560163&form=6&db=m Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17616810&form=6&db=m The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17628743&form=6&db=m INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase, enhances tumor response to doxorubicin. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17669606&form=6&db=m 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces oxidative stress, DNA strand breaks, and poly(ADP-ribose) polymerase-1 activation in human breast carcinoma cell lines. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17896912&form=6&db=m PARP inhibitor development for systemic cancer targeting. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17897439&form=6&db=m Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17943227&form=6&db=m Genetic sequence variations and ADPRT haplotype analysis in French Canadian families with high risk of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18058803&form=6&db=m Novel synthetic triterpenoid methyl 25-hydroxy-3-oxoolean-12-en-28-oate induces apoptosis through JNK and p38 MAPK pathways in human breast adenocarcinoma MCF-7 cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18164959&form=6&db=m Resveratrol-induced apoptosis in human breast cancer cells is mediated primarily through the caspase-3-dependent pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18334030&form=6&db=m Period-2: a tumor suppressor gene in breast cancer. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18377693&form=6&db=m Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18558727&form=6&db=m 2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the induction of DNA strand breaks and poly(ADP-ribose) polymerase-1 activation by 17beta-estradiol in human breast carcinoma cells through alteration of CYP1A1 and CYP1B1 expression. ongoing research,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18701435&form=6&db=m Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,2 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18718551&form=6&db=m Selenocystine induces caspase-independent apoptosis in MCF-7 human breast carcinoma cells with involvement of p53 phosphorylation and reactive oxygen species generation. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18800822&form=6&db=m 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18832051&form=6&db=m A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18837894&form=6&db=m The potential of PARP inhibitors in genetic breast and ovarian cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18971340&form=6&db=m High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19060926&form=6&db=m Ionizing radiation-induced NF-kappaB activation requires PARP-1 function to confer radioresistance. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19118525&form=6&db=m Tosylcyclonovobiocic acids promote cleavage of the hsp90-associated cochaperone p23. therapeutic application,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19146838&form=6&db=m Caspase- and p53-dependent apoptosis in breast carcinoma cells induced by a synthetic selenadiazole derivative. ongoing research,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19221498&form=6&db=m Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19242112&form=6&db=m ON-III inhibits erbB-2 tyrosine kinase receptor signal pathway and triggers apoptosis through induction of Bim in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19287209&form=6&db=m Enhancing radiosensitivity: targeting the DNA repair pathways. therapeutic application,unassigned 2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19351835&form=6&db=m Defective repair of oxidative dna damage in triple-negative breast cancer confers sensitivity to inhibition of poly(ADP-ribose) polymerase. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19455741&form=6&db=m BiPar Sciences presents interim phase 2 results for PARP inhibitor BSI-201 at San Antonio Breast Cancer Symposium. therapeutic application,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19513550&form=6&db=m gammaH2AX and cleaved PARP-1 as apoptotic markers in irradiated breast cancer BT474 cellular spheroids. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19716891&form=6&db=m Activation of choline kinase by extracellular Ca2+ is Ca(2+)-sensing receptor, Galpha12 and Rho-dependent in breast cancer cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19773755&form=6&db=m Mutant p53 mediates survival of breast cancer cells. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19804613&form=6&db=m Development of 'synthetic lethal' strategies to target BRCA1-deficient breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19812418&form=6&db=m Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells. ongoing research,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19828406&form=6&db=m Targeted therapy of metastatic breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19855437&form=6&db=m Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19891779&form=6&db=m A selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyADP-ribose polymerase inhibitors. ongoing research,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19934756&form=6&db=m The emerging potential of poly(ADP-ribose) polymerase inhibitors in the treatment of breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19939726&form=6&db=m PARP inhibitors in cancer therapy: two modes of attack on the cancer cell widening the clinical applications. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20017885&form=6&db=m PARP inhibitors and the treatment of breast cancer: beyond BRCA1/2? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20020667&form=6&db=m PARP inhibition in breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20049735&form=6&db=m Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20131991&form=6&db=m Highlights of the Chemotherapy Foundation Symposium XXVII: therapeutic options for breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20145144&form=6&db=m Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20164690&form=6&db=m Poly(ADP-ribose) polymerase inhibitors in triple-negative breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20179194&form=6&db=m Bitter melon (Momordica charantia) extract inhibits breast cancer cell proliferation by modulating cell cycle regulatory genes and promotes apoptosis. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20187322&form=6&db=m Inhibition of poly(ADP)-ribose polymerase as a therapeutic strategy for breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20385443&form=6&db=m Targeting DNA repair in breast cancer: A clinical and translational update. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20446019&form=6&db=m 4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20498641&form=6&db=m Elevated expression of erbB3 confers paclitaxel resistance in erbB2-overexpressing breast cancer cells via upregulation of Survivin. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20568893&form=6&db=m PARP-1 inhibitors: a novel genetically specific agents for cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20594311&form=6&db=m Tamoxifen enhances the cytotoxic effects of nelfinavir in breast cancer cells. ongoing research,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20596620&form=6&db=m Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20609467&form=6&db=m Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20610628&form=6&db=m Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20647696&form=6&db=m [Breakthrough breast cancer treatment--PARP inhibitor, BRCA, and triple negative breast cancer] diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20664514&form=6&db=m A review of triple-negative breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20684551&form=6&db=m Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20707719&form=6&db=m Tumor-suppressive effect of adenovirus-mediated inhibitor of growth 4 gene transfer in breast carcinoma cells in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20717927&form=6&db=m Lysyl oxidase propeptide sensitizes pancreatic and breast cancer cells to doxorubicin-induced apoptosis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20802015&form=6&db=m A marker of homologous recombination predicts pathological complete response to neoadjuvant chemotherapy in primary breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20858840&form=6&db=m Poly(ADP-Ribose) polymerase inhibition: "Targeted" therapy for triple-negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20948822&form=6&db=m PARP inhibitors in BRCA1/BRCA2 germline mutation carriers with ovarian and breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21048307&form=6&db=m Tanshinone IIA Induces Mitochondria Dependent Apoptosis in Prostate Cancer Cells in Association with an Inhibition of Phosphoinositide 3-Kinase/AKT Pathway. therapeutic application,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21058201&form=6&db=m Anticancer activities of an anthocyanin-rich extract from black rice against breast cancer cells in vitro and in vivo. causal interaction,ongoing research,unassigned 4,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21069454&form=6&db=m Poly(ADP-ribose) polymerase-1 mRNA expression in human breast cancer: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21157412&form=6&db=m PARP Inhibitors in Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21184665&form=6&db=m Blockade of MUC1 expression by glycerol guaiacolate inhibits proliferation of human breast cancer cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21195000&form=6&db=m miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21259053&form=6&db=m Bufadienolide compounds sensitize human breast cancer cells to TRAIL-induced apoptosis via inhibition of STAT3/Mcl-1 pathway. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21300207&form=6&db=m PARP inhibitor treatment in ovarian and breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21316599&form=6&db=m PARP inhibitors in cancer therapy: promise, progress, and puzzles. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21370912&form=6&db=m Metal-Based Inhibition of Poly(ADP-ribose) Polymerase - The Guardian Angel of DNA. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21409392&form=6&db=m PARP-1 expression in breast cancer including BRCA1-associated, triple negative and basal-like tumors: possible implications for PARP-1 inhibitor therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21424107&form=6&db=m Poly (ADP-ribose) polymerase-1 Inhibition: Preclinical and Clinical Development of Synthetic Lethality. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21429729&form=6&db=m Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21497990&form=6&db=m HDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2-overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21519019&form=6&db=m Cytoplasmic poly(adenosine diphosphate-ribose) polymerase expression is predictive and prognostic in patients with breast cancer treated with neoadjuvant chemotherapy. therapeutic application,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21532888&form=6&db=m p38? mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase-1 inhibition in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21552220&form=6&db=m PARP inhibitors stumble in breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21590040&form=6&db=m Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21594366&form=6&db=m Enhancement of chemotherapeutically-induced apoptosis in vivo by biochemical modulation of poly (ADP-ribose) polymerase. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21607289&form=6&db=m Cordycepin blocks lung injury-associated inflammation and promotes BRCA1-deficient breast cancer cell killing by effectively inhibiting PARP. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21618343&form=6&db=m Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer. therapeutic application,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21681448&form=6&db=m Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21700777&form=6&db=m Genetic polymorphisms of multiple DNA repair pathways impact age at diagnosis and TP53 mutations in breast cancer. therapeutic application,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21706452&form=6&db=m Targeted therapy in breast cancer: what's new? causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21707865&form=6&db=m Response of subtype-specific human breast cancer-derived cells to poly(ADP-ribose) polymerase and checkpoint kinase 1 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21884642&form=6&db=m Poly(ADP-ribose) polymerase inhibition: a new direction for BRCA and triple-negative breast cancer? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21908496&form=6&db=m Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21916578&form=6&db=m Therapeutic potential of PARP inhibitors for metastatic breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22015278&form=6&db=m PARP inhibitors--current status and the walk towards early breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22035512&form=6&db=m Recent developments in treatment stratification for metastatic breast cancer. causal interaction,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22043054&form=6&db=m The triple-negative subtype: new ideas for the poorest prognosis breast cancer. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22106552&form=6&db=m PARP inhibitors in breast cancer: BRCA and beyond. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22106554&form=6&db=m PARP inhibitors and their evolving role in breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22116506&form=6&db=m Somatic mutations in the BRCA1 gene in Chinese women with sporadic breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22157293&form=6&db=m BRCA mutation testing in determining breast cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22166496&form=6&db=m The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22179721&form=6&db=m Methylseleninic acid potentiates multiple types of cancer cells to ABT-737-induced apoptosis by targeting Mcl-1 and Bad. ongoing research,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22207897&form=6&db=m Anti-miR-203 Upregulates SOCS3 Expression in Breast Cancer Cells and Enhances Cisplatin Chemosensitivity. ongoing research,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22226932&form=6&db=m Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22240506&form=6&db=m Integrated proteomic, transcriptomic, and biological network analysis of breast carcinoma reveals molecular features of tumorigenesis and clinical relapse. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22263793&form=6&db=m Triple-negative breast cancer and Poly(ADP-ribose) polymerase inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22266096&form=6&db=m Co-targeting of the PI3K pathway improves the response of BRCA1 deficient breast cancer cells to PARP1 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22318550&form=6&db=m Gene expression and pathologic response to neoadjuvant chemotherapy in breast cancer. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22443171&form=6&db=m Poly (ADP-ribose) polymerase (PARP): rationale, preclinical and clinical evidences of its inhibition as breast cancer treatment. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22450359&form=6&db=m [PARP inhibitors and breast cancer: update and perspectives]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22454224&form=6&db=m Antitumor and anticancer stem cell activity of a poly ADP-ribose polymerase inhibitor olaparib in breast cancer cells. therapeutic application,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22464251&form=6&db=m Rare mutations in XRCC2 increase the risk of breast cancer. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22549111&form=6&db=m MGMT Inhibition Restores ER? Functional Sensitivity to Anti-Estrogen Therapy. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22586318&form=6&db=m Stumbling blocks on the path to personalized medicine in breast cancer: the case of PARP inhibitors for BRCA1/2-associated cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22596349&form=6&db=m Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in mammary tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22655123&form=6&db=m PARP Inhibitors for the Treatment and Prevention of Breast Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22689920&form=6&db=m BCL2 Suppresses PARP1 Function and Nonapoptotic Cell Death. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22706117&form=6&db=m [PARP inhibitors--theoretical basis and clinical application]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22820987&form=6&db=m BRCA1-methylated sporadic breast cancers are BRCA-like in showing a basal phenotype and absence of ER expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22906755&form=6&db=m PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22915751&form=6&db=m Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for a mouse model of BRCA1-related breast cancer. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22915752&form=6&db=m PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA proficient triple negative breast cancer to PARP inhibition. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22948662&form=6&db=m CDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22955851&form=6&db=m Erythropoietin-driven signalling and cell migration mediated by polyADP-ribosylation. therapeutic application,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22962264&form=6&db=m Targeting BRCA1 localization to augment breast tumor sensitivity to poly(ADP-ribose) polymerase inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22968923&form=6&db=m Higher cytoplasmic and nuclear poly(ADP-ribose) polymerase expression in familial than in sporadic breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22987487&form=6&db=m HER2 Overexpression Renders Human Breast Cancers Sensitive to PARP Inhibition Independently of Any Defect in Homologous Recombination DNA Repair. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23043339&form=6&db=m Airborne particulate collected from central Taiwan induces DNA strand breaks, Poly(ADP-ribose) polymerase-1 activation, and estrogen-disrupting activity in human breast carcinoma cell lines. ongoing research,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23071597&form=6&db=m Synthetic lethal interactions between EGFR and PARP inhibition in human triple negative breast cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23148373&form=6&db=m The promise of combining inhibition of PI3K and PARP as cancer therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23203101&form=6&db=m A DNA Repair BRCA1 Estrogen Receptor and Targeted Therapy in Breast Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23244082&form=6&db=m XRCC1 and ADPRT polymorphisms associated with survival in breast cancer cases treated with chemotherapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23275542&form=6&db=m 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. causal interaction,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23293602&form=6&db=m Is there an epigenetic component underlying the resistance of triple-negative breast cancers to parp inhibitors? causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23315029&form=6&db=m Evaluation of the pharmacodynamics and pharmacokinetics of the PARP inhibitor olaparib: a Phase I multicentre trial in patients scheduled for elective breast cancer surgery. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23376119&form=6&db=m p63 involvement in poly(ADP-ribose) polymerase 1 signaling of topoisomerase I-dependent DNA damage in carcinoma cells. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23386910&form=6&db=m Treating breast cancer in the 21st century: emerging biological therapies. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23508743&form=6&db=m Methoxyphenylcipro induces antitumor activity in human cancer cells. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23510475&form=6&db=m Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity. therapeutic application,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23605692&form=6&db=m Using multiple targeted therapies in oncology: considerations for use, and progress to date in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23644255&form=6&db=m Effects of passive smoking on breast cancer risk in pre/post-menopausal women as modified by polymorphisms of PARP1 and ESR1. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23760496&form=6&db=m Comparative antiproliferative effects of iniparib and olaparib on a panel of triple-negative and non-triple-negative breast cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23803078&form=6&db=m The C Allele of a Synonymous SNP (rs1805414, Ala284Ala) in PARP1 is a Risk Factor for Susceptibility to Breast Cancer in Saudi Patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23810467&form=6&db=m A Phase 1 trial of the poly(ADP-ribose) polymerase inhibitor olaparib (AZD2281) in combination with the anti-angiogenic cediranib (AZD2171) in recurrent epithelial ovarian or triple-negative breast cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23851505&form=6&db=m GATA3 cooperates with PARP1 to regulate CCND1 transcription through modulating histone H1 incorporation. therapeutic application,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23883585&form=6&db=m Catalase Abrogates ?-Lapachone-Induced PARP1 Hyperactivation-Directed Programmed Necrosis in NQO1-Positive Breast Cancers. ongoing research,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24085845&form=6&db=m Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24131964&form=6&db=m BRCAness: a deeper insight into basal-like breast tumors. causal interaction,unassigned 2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24147361&form=6&db=m Synthesis, cytotoxic evaluation and molecular docking study of novel quinazoline derivatives as PARP-1 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24191908&form=6&db=m BRCA1 promoter hypermethylation, 53BP1 protein expression and PARP-1 activity as biomarkers of DNA repair deficit in breast cancer. diagnostic usage,therapeutic application,unassigned 1,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24240613&form=6&db=m JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24252502&form=6&db=m ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24293218&form=6&db=m PPAR?-inactive ?2-troglitazone independently triggers ER stress and apoptosis in breast cancer cells. therapeutic application,unassigned 2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24337974&form=6&db=m Pyrosequencing analysis of BRCA1 methylation level in breast cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24378347&form=6&db=m The CDK1 inhibitor RO3306 improves the response of BRCA-pro?cient breast cancer cells to PARP inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24392019&form=6&db=m Association between PARP-1 V762A polymorphism and breast cancer susceptibility in Saudi population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24441188&form=6&db=m Correlation between PARP-1 immunoreactivity and cytomorphological features of parthanatos, a specific cellular death in breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24535158&form=6&db=m Nuclear-cytoplasmic PARP-1 expression as an unfavorable prognostic marker in lymph node?negative early breast cancer: 15-year follow-up. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24556691&form=6&db=m Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer. ongoing research,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24563619&form=6&db=m Doubling down on the PI3K-AKT-mTOR pathway enhances the antitumor efficacy of PARP inhibitor in triple negative breast cancer model beyond BRCA-ness. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24609113&form=6&db=m Correction: Association between PARP-1 V762A Polymorphism and Breast Cancer Susceptibility in Saudi Population. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24625110&form=6&db=m A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity. therapeutic application,unassigned 2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24826054&form=6&db=m PARP inhibitor reduces proliferation and increases apoptosis in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24865236&form=6&db=m The cyclin-dependent kinase inhibitor SNS-032 induces apoptosis in breast cancer cells via depletion of Mcl-1 and X-linked inhibitor of apoptosis protein and displays antitumor activity in vivo. therapeutic application,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24962108&form=6&db=m Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24962512&form=6&db=m Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) Restrict Oral Availability and Brain Accumulation of the PARP Inhibitor Rucaparib (AG-014699). therapeutic application,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24963051&form=6&db=m Functional Ex Vivo Assay to Select Homologous Recombination-Deficient Breast Tumors for PARP Inhibitor Treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24970803&form=6&db=m Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25026298&form=6&db=m Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25027398&form=6&db=m Verrucarin A alters cell-cycle regulatory proteins and induces apoptosis through reactive oxygen species-dependent p38MAPK activation in the human breast cancer cell line MCF-7. ongoing research,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25085902&form=6&db=m Modulation of the poly (ADP-ribose) polymerase inhibitor response and DNA recombination in breast cancer cells by drugs affecting endogenous wild-type p53. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25103497&form=6&db=m TGF? induces "BRCAness" and sensitivity to PARP inhibition in breast cancer by regulating DNA-repair genes. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25104443&form=6&db=m Targeted radiosensitization with PARP1 inhibition: optimization of therapy and identification of biomarkers of response in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25111287&form=6&db=m Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers? diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25128455&form=6&db=m Poly (ADP-ribose) polymerase inhibition enhances trastuzumab antitumour activity in HER2 overexpressing breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25144364&form=6&db=m Poly(ADP-ribose) polymerase 1 (PARP1) overexpression in human breast cancer stem cells and resistance to olaparib. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25199834&form=6&db=m Basal activity of a PARP1-NuA4 complex varies dramatically across cancer cell lines. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25206307&form=6&db=m Clinical potential of novel therapeutic targets in breast cancer: CDK4/6, Src, JAK/STAT, PARP, HDAC, and PI3K/AKT/mTOR pathways. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25286972&form=6&db=m An update on PARP inhibitors--moving to the adjuvant setting. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25333773&form=6&db=m Selective anticancer effects and protection from chemotherapy by the botanical compound LCS101: Implications for cancer treatment. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25337234&form=6&db=m Effect of adriamycin on BRCA1 and PARP-1 expression in MCF-7 breast cancer cells. ongoing research,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25337581&form=6&db=m Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25342917&form=6&db=m Novel treatment strategies in triple-negative breast cancer: specific role of poly(adenosine diphosphate-ribose) polymerase inhibition. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25377255&form=6&db=m The role of Kif4A in doxorubicin-induced apoptosis in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25442825&form=6&db=m [New targeted therapies in breast cancer]. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25480692&form=6&db=m The nuclear expression of poly (ADP-ribose) polymerase-1 (PARP1) in invasive primary breast tumors is associated with chemotherapy sensitivity. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25485588&form=6&db=m A novel crosstalk between BRCA1 and poly (ADP-ribose) polymerase 1 in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25504347&form=6&db=m Nicotinamide sensitizes human breast cancer cells to the cytotoxic effects of radiation and cisplatin. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25511378&form=6&db=m BRCA2-Deficient Sarcomatoid Mammary Tumors Exhibit Multidrug Resistance. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25528020&form=6&db=m Biological and clinical significance of PARP1 protein expression in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25611238&form=6&db=m The Prognostic and Predictive Significance of PARP-1 in Locally Advanced Breast Cancer of Egyptian Patients Receiving Neoadjuvant Chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25614115&form=6&db=m Discovery of 1-substituted benzyl-quinazoline-2,4(1H,3H)-dione derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25634209&form=6&db=m Interaction of BARD1 and HP1 is required for BRCA1 retention at sites of DNA damage. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25667043&form=6&db=m Effect of poly(ADP-ribose)polymerase and DNA topoisomerase I inhibitors on the p53/p63-dependent survival of carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25677620&form=6&db=m Ferulic acid in combination with PARP inhibitor sensitizes breast cancer cells as chemotherapeutic strategy. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25679396&form=6&db=m LSD1 Overexpression Is Associated with Poor Prognosis in Basal-Like Breast Cancer, and Sensitivity to PARP Inhibition. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25733866&form=6&db=m Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25738259&form=6&db=m Erratum to "Doubling Down on the PI3K-AKTmTOR Pathway Enhances the Antitumor Efficacy of PARP Inhibitor in Triple Negative Breast Cancer Model beyond BRCA-ness" [Neoplasia 16 (2014) 43-72]. therapeutic application,unassigned 2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25764827&form=6&db=m [On the prospects of using the DNA repair inhibitors in radiotherapy of tumors]. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25769025&form=6&db=m HP1? Is a Biomarker for Breast Cancer Prognosis and PARP Inhibitor Therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25796377&form=6&db=m Breast cancer under age 40: a different approach. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25811344&form=6&db=m Sequences and combinations of multifaceted therapy in advanced prostate cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25812606&form=6&db=m Epigenetic bivalent marking is permissive to the synergy of HDAC and PARP inhibitors on TXNIP expression in breast cancer cells. causal interaction,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25833211&form=6&db=m PARP1 and phospho-p65 protein expression is increased in human HER2-positive breast cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25865228&form=6&db=m Autoimmune response to PARP and BRCA1/BRCA2 in cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25875848&form=6&db=m Correction: HP1? is a biomarker for breast cancer prognosis and PARP inhibitor therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25884663&form=6&db=m Radiosensitization with combined use of olaparib and PI-103 in triple-negative breast cancer. therapeutic application,unassigned 2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25975349&form=6&db=m The PARP inhibitor AZD2281 (Olaparib) induces autophagy/mitophagy in BRCA1 and BRCA2 mutant breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25981734&form=6&db=m Differential Potential of Pharmacological PARP Inhibitors for Inhibiting Cell Proliferation and Inducing Apoptosis in Human Breast Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26048134&form=6&db=m Effect of Food on the Pharmacokinetics of Olaparib after Oral Dosing of the Capsule Formulation in Patients with Advanced Solid Tumors. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26083304&form=6&db=m In silico investigation of PARP-1 catalytic domains in holo and apo states for the design of high-affinity PARP-1 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26097394&form=6&db=m PARP inhibitors and more. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26100884&form=6&db=m Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26124328&form=6&db=m Co-treatment with BEZ235 Enhances Sensitivity of BRCA1-negative Breast Cancer Cells to Olaparib. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26177331&form=6&db=m KIFC1 is a novel potential therapeutic target for breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26183824&form=6&db=m Poly(ADP-ribose) polymerase as a novel regulator of 17?-estradiol-induced cell growth through a control of the estrogen receptor/IGF-1 receptor/PDZK1 axis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26237679&form=6&db=m Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26241555&form=6&db=m Effect of Oncoxin Oral Solution in HER2-Overexpressing Breast Cancer. causal interaction,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26261599&form=6&db=m Polymorphisms in poly (ADP-ribose) polymerase-1 (PARP1) promoter and 3' untranslated region and their association with PARP1 expression in breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26268938&form=6&db=m PARP inhibitors in the management of breast cancer: current data and future prospects. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26294743&form=6&db=m Differences in Expression of Key DNA Damage Repair Genes after Epigenetic-Induced BRCAness Dictate Synthetic Lethality with PARP1 Inhibition. therapeutic application,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26310369&form=6&db=m Expression of DNA Damage Response Molecules PARP1, ?H2AX, BRCA1, and BRCA2 Predicts Poor Survival of Breast Carcinoma Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26350251&form=6&db=m Curcumin enhances poly(ADP-ribose) polymerase inhibitor sensitivity to chemotherapy in breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26384693&form=6&db=m [From poly(ADP-ribose) discovery to PARP inhibitors in cancer therapy]. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26483957&form=6&db=m PARP1 Inhibitors: antitumor drug design. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26483970&form=6&db=m Apigenin Inhibits Growth of Breast Cancer Cells: The Role of ER? and HER2/neu. therapeutic application,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26485111&form=6&db=m Advances in PARP inhibitors for the treatment of breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26530780&form=6&db=m Adenovirus-mediated p53 and ING4 gene co?transfer elicits synergistic antitumor effects through enhancement of p53 acetylation in breast cancer. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26563438&form=6&db=m Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization. ongoing research,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26614429&form=6&db=m Nuclear PARP1 expression and its prognostic significance in breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26683774&form=6&db=m The synthetic ?-nitrostyrene derivative CYT-Rx20 induces breast cancer cell death and autophagy via ROS-mediated MEK/ERK pathway. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26713604&form=6&db=m Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26770239&form=6&db=m Synergistic Effect of Trabectedin and Olaparib Combination Regimen in Breast Cancer Cell Lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26779812&form=6&db=m Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26800494&form=6&db=m Genetic and epigenetic heterogeneity of epithelial ovarian cancer and the clinical implications for molecular targeted therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26801247&form=6&db=m Phase I Study of Veliparib (ABT-888) Combined with Cisplatin and Vinorelbine in Advanced Triple-Negative Breast Cancer and/or BRCA Mutation-Associated Breast Cancer. therapeutic application,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26826460&form=6&db=m Decreased DNA repair gene XRCC1 expression is associated with radiotherapy-induced acute side effects in breast cancer patients. ongoing research,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26920250&form=6&db=m Poly (ADP-ribose) polymerases inhibitor, Zj6413, as a potential therapeutic agent against breast cancer. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26935527&form=6&db=m Triptolide sensitizes human breast cancer cells to tumor necrosis factor???induced apoptosis by inhibiting activation of the nuclear factor??B pathway. causal interaction,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27002934&form=6&db=m Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27036617&form=6&db=m An HTS-compatible HTRF assay measuring the glycohydrolase activity of human PARG. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27069769&form=6&db=m [(18)F]FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27151591&form=6&db=m Deoxyrhapontigenin, a Natural Stilbene Derivative Isolated From Rheum undulatum L. Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in Human Breast Cancer Cells. causal interaction,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27181206&form=6&db=m RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27228289&form=6&db=m Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27323902&form=6&db=m A phase I followed by a randomized phase II trial of two cycles carboplatin-olaparib followed by olaparib monotherapy versus capecitabine in BRCA1- or BRCA2-mutated HER2-negative advanced breast cancer as first line treatment (REVIVAL): study protocol for a randomized controlled trial. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27334689&form=6&db=m ABT-888 and quinacrine induced apoptosis in metastatic breast cancer stem cells by inhibiting base excision repair via adenomatous polyposis coli. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27374177&form=6&db=m ART3 regulates triple-negative breast cancer cell function via activation of Akt and ERK pathways. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27385001&form=6&db=m miR-151-5p, targeting chromatin remodeler SMARCA5, as a marker for the BRCAness phenotype. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27426307&form=6&db=m Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27437145&form=6&db=m Inhibition of Poly(ADP-Ribose) Polymerase by Nucleic Acid Metabolite 7-Methylguanine. therapeutic application,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27454289&form=6&db=m RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27579892&form=6&db=m PARP3 controls TGF? and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27600289&form=6&db=m d-3-Deoxy-dioctanoylphosphatidylinositol induces cytotoxicity in human MCF-7 breast cancer cells via a mechanism that involves downregulation of the D-type cyclin-retinoblastoma pathway. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27600429&form=6&db=m Isoalantolactone induces apoptosis in human breast cancer cells via ROS-mediated mitochondrial pathway and downregulation of SIRT1. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27613518&form=6&db=m 53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27727003&form=6&db=m Non-NAD-Like poly(ADP-Ribose) Polymerase-1 Inhibitors effectively Eliminate Cancer in vivo. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27728808&form=6&db=m Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27739325&form=6&db=m A randomized Phase II study of veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in BRCA1/2 metastatic breast cancer: design and rationale. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27740936&form=6&db=m Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27760931&form=6&db=m [The Role of Preoperative Chemotherapy Depending on Breast Cancer Subtype]. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27811964&form=6&db=m The Poly (ADP-Ribose) Polymerase Inhibitor Veliparib and Radiation Cause Significant Cell Line Dependent Metabolic Changes in Breast Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27863838&form=6&db=m Resveratrol enhances the efficacy of sorafenib mediated apoptosis in human breast cancer MCF7 cells through ROS, cell cycle inhibition, caspase 3 and PARP cleavage. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27899080&form=6&db=m Erratum to: 53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27920426&form=6&db=m Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27997688&form=6&db=m Novel splice-switching oligonucleotide promotes BRCA1 aberrant splicing and susceptibility to PARP inhibitor action. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28025102&form=6&db=m Somatostatin receptor targeted liposomes with Diacerein inhibit IL-6 for breast cancer therapy. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28031413&form=6&db=m Let-7 Status Is Crucial for PARP1 Expression in HER2-Overexpressing Breast Tumors. diagnostic usage,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28034453&form=6&db=m DNA damage repair in breast cancer and its therapeutic implications. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28034904&form=6&db=m RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28111726&form=6&db=m Ganetespib overcomes resistance to PARP inhibitors in breast cancer by targeting core proteins in the DNA repair machinery. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28122957&form=6&db=m Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28123587&form=6&db=m Analysis of molecular markers as predictive factors of lymph node involvement in breast carcinoma. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28138868&form=6&db=m Combination treatment using DDX3 and PARP inhibitors induces synthetic lethality in BRCA1-proficient breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28183251&form=6&db=m The Real Impact of Target Therapy in Breast Cancer Patients: Between Hope and Reality. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28209156&form=6&db=m BreastDefend enhances effect of tamoxifen in estrogen receptor-positive human breast cancer in vitro and in vivo. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28212434&form=6&db=m Prognostic and clinicopathological value of poly (adenosine diphosphate-ribose) polymerase expression in breast cancer: A meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28249538&form=6&db=m PARP inhibitor and platinum agent in triple negative breast cancer: utilizing innovative trial design to bring together something "new" and something "old". unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28288110&form=6&db=m HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28316110&form=6&db=m Proteasome ubiquitin receptor PSMD4 is an amplification target in breast cancer and may predict sensitivity to PARPi. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28336669&form=6&db=m A conserved NAD(+) binding pocket that regulates protein-protein interactions during aging. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28347815&form=6&db=m Sigma-2 ligands and PARP inhibitors synergistically trigger cell death in breast cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28356425&form=6&db=m Efficacy of the PARP Inhibitor Veliparib with Carboplatin or as a Single Agent in Patients with Germline BRCA1- or BRCA2-Associated Metastatic Breast Cancer. therapeutic application,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28359295&form=6&db=m Rad51 inhibition sensitizes breast cancer stem cells to PARP inhibitor in triple-negative breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28377996&form=6&db=m Data on the effects of anti-cancer drug of resveratrol in breast cancer cells, MDA-MB-231 cells. therapeutic application,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28395540&form=6&db=m Olaparib for the treatment of breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28442756&form=6&db=m Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454214&form=6&db=m Genome-wide analysis of gynecologic cancer: The Cancer Genome Atlas in ovarian and endometrial cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28479725&form=6&db=m Antiproliferative and Proapoptotic Activities of Marine Sponge Hyrtios erectus Extract on Breast Carcinoma Cell Line (MCF-7). ongoing research,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28505207&form=6&db=m Immuno-related polymorphisms and cervical cancer risk: The IARC multicentric case-control study. diagnostic usage,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28513990&form=6&db=m Network Meta-Analysis on the Effects of DNA Damage Response-Related Gene Mutations on Overall Survival of Breast Cancer Based on TCGA Database. ongoing research,unassigned 2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28583748&form=6&db=m Development of PARP inhibitors in gynecological malignancies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28583909&form=6&db=m Olaparib Keeps Hereditary Breast Tumors in Check. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28660502&form=6&db=m Down-regulation of PARP1 by miR-891b sensitizes human breast cancer cells to alkylating chemotherapeutic drugs. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28677724&form=6&db=m TNFR2 promotes Adriamycin resistance in breast cancer cells by repairing DNA damage. therapeutic application,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28681938&form=6&db=m ?-hydroxyundec-9-enoic acid induces apoptosis by ROS mediated JNK and p38 phosphorylation in breast cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28692916&form=6&db=m Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28759294&form=6&db=m Epidermal Growth Factor Receptor activation promotes ADA3 acetylation through the AKT-p300 pathway. therapeutic application,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28759753&form=6&db=m Inhibition of Rad51 sensitizes breast cancer cells with wild-type PTEN to olaparib. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28765325&form=6&db=m Diverse BRCA1 and BRCA2 Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28770827&form=6&db=m Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy. causal interaction,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28821270&form=6&db=m Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion. therapeutic application,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28880389&form=6&db=m More breast cancer patients could benefit from PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28893315&form=6&db=m Heterogeneous drug penetrance of veliparib and carboplatin measured in triple negative breast tumors. therapeutic application,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28925391&form=6&db=m EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29029467&form=6&db=m NHERF1 together with PARP1 and BRCA1 expression as a new potential biomarker to stratify breast cancer patients. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29093017&form=6&db=m A Population of Heterogeneous Breast Cancer Patient-Derived Xenografts Demonstrate Broad Activity of PARP Inhibitor in BRCA1/2 Wild-Type Tumors. therapeutic application,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29152062&form=6&db=m Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29167821&form=6&db=m PTK6 regulates growth and survival of endocrine therapy-resistant ER+ breast cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29180466&form=6&db=m Synthetic Lethality of PARP Inhibitors in Combination with MYC Blockade Is Independent of BRCA Status in Triple-Negative Breast Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29202431&form=6&db=m Triple negative breast cancer: Emerging therapeutic modalities and novel combination therapies. therapeutic application,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29207607&form=6&db=m Cyclin A2 regulates homologous recombination DNA repair and sensitivity to DNA damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors in human breast cancer cells. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29212245&form=6&db=m RBR-type E3 ubiquitin ligase RNF144A targets PARP1 for ubiquitin-dependent degradation and regulates PARP inhibitor sensitivity in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29290761&form=6&db=m The OlympiAD trial: who won the gold? therapeutic application,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29312562&form=6&db=m Downregulation of miR-221-3p and upregulation of its target gene PARP1 are prognostic biomarkers for triple negative breast cancer patients and associated with poor prognosis. causal interaction,diagnostic usage,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29382645&form=6&db=m First PARP Inhibitor Ok'd for Breast Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29427345&form=6&db=m Crosstalk of DNA double-strand break repair pathways in poly(ADP-ribose) polymerase inhibitor treatment of breast cancer susceptibility gene 1/2-mutated cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29484706&form=6&db=m Identification of a novel truncating mutation in PALB2 gene by a multigene sequencing panel for mutational screening of breast cancer risk-associated and related genes. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29533979&form=6&db=m Sustained Cytotoxicity of Wogonin on Breast Cancer Cells by Encapsulation in Solid Lipid Nanoparticles. ongoing research,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29555478&form=6&db=m Inhibition of TACC3 by a small molecule inhibitor in breast cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29582690&form=6&db=m Olaparib for the treatment of breast cancer. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29587668&form=6&db=m Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-?-linolenic acid peroxidation dependent mechanism. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29592880&form=6&db=m Trastuzumab resistant HER2+ breast cancer cells retain sensitivity to poly (ADP-ribose) polymerase (PARP) inhibition. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29635390&form=6&db=m RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29644491&form=6&db=m Update on PARP Inhibitors in Breast Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29658592&form=6&db=m In vitro cytotoxic effect of PARP inhibitor alone and in combination with nab?paclitaxel on triple?negative and luminal A breast cancer cells. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29660759&form=6&db=m PARP inhibitors in breast cancer: Bringing synthetic lethality to the bedside. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29684820&form=6&db=m Increased oxidative stress mediates the antitumor effect of PARP inhibition in ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29740495&form=6&db=m In vitro assessment of the role of DpC in the treatment of head and neck squamous cell carcinoma. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29753961&form=6&db=m The role of PARP inhibition in triple-negative breast cancer: Unraveling the wide spectrum of synthetic lethality. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29754052&form=6&db=m Detection of PARP-1 activity based on hyperbranched-poly (ADP-ribose) polymers responsive current in artificial nanochannels. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29851928&form=6&db=m The evolution of poly(ADP-ribose) polymerase inhibitors in the treatment of breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29867226&form=6&db=m BRCA1/2 testing: therapeutic implications for breast cancer management. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29870916&form=6&db=m Emerging therapeutic modalities of PARP inhibitors in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29874127&form=6&db=m Poly(ADP-ribose) polymerase-1 promotes recruitment of meiotic recombination-11 to chromatin and DNA double-strand break repair in Ku70-deficient breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29879343&form=6&db=m [Olaparib potentiates the antitumor effect of Taxol on 4T1 breast cancer]. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29884921&form=6&db=m Where Do We Stand on the Integration of PARP Inhibitors for the Treatment of Breast Cancer? causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29911447&form=6&db=m Niraparib for the treatment of ovarian cancer. therapeutic application,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29917049&form=6&db=m Breast cancer brain metastases show increased levels of genomic aberration-based homologous recombination deficiency scores relative to their corresponding primary tumors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29942664&form=6&db=m Single-agent PARP inhibitors for the treatment of patients with BRCA-mutated HER2-negative metastatic breast cancer: a systematic review and meta-analysis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29955114&form=6&db=m Synthetic lethal therapies for cancer: what's next after PARP inhibitors? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29979319&form=6&db=m Relevance of poly (ADP-ribose) polymerase inhibitors in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30022119&form=6&db=m Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30023007&form=6&db=m Dancing with the DNA damage response: next-generation anti-cancer therapeutic strategies. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30038706&form=6&db=m Inhibition of mTOR downregulates expression of DNA repair proteins and is highly efficient against BRCA2-mutated breast cancer in combination to PARP inhibition. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30039287&form=6&db=m PARP3 inhibitors ME0328 and olaparib potentiate vinorelbine sensitization in breast cancer cell lines. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30067621&form=6&db=m Development of poly(ADP-ribose) polymerase inhibitors in the treatment of BRCA-mutated breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30069183&form=6&db=m PARP Inhibitors in Breast Cancer: Why, How, and When? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30100991&form=6&db=m Prosopis juliflora (Sw.), DC induces apoptosis and cell cycle arrest in triple negative breast cancer cells: in vitro and in vivo investigations. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30108102&form=6&db=m Kub5-Hera RPRD1B Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30116283&form=6&db=m Advances in the use of PARP inhibitor therapy for breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30118334&form=6&db=m Olaparib tablets for the treatment of germ line BRCA-mutated metastatic breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30119256&form=6&db=m Synergy of theophylline reduces necrotic effect of berberine, induces cell cycle arrest and PARP, HMGB1, Bcl-2 family mediated apoptosis in MDA-MB-231 breast cancer cells. causal interaction,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30177437&form=6&db=m Mechanisms of PARP inhibitor sensitivity and resistance. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30181424&form=6&db=m Resurrection of PARP Inhibitors in Breast Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30211078&form=6&db=m Gallic acid and curcumin induce cytotoxicity and apoptosis in human breast cancer cell MDA-MB-231. causal interaction,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30217455&form=6&db=m 4-Hydroxybenzoic acid (4-HBA) enhances the sensitivity of human breast cancer cells to adriamycin as a specific HDAC6 inhibitor by promoting HIPK2/p53 pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30222135&form=6&db=m Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30232143&form=6&db=m Androgen receptor inhibitor enhances the anti-tumor effect of PARP inhibitor in breast cancer cells by modulating DNA damage response. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30234015&form=6&db=m MicroRNAs and DNA-Damaging Drugs in Breast Cancer: Strength in Numbers. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30251552&form=6&db=m Emerging PARP inhibitors for treating breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30252484&form=6&db=m ABCB1 Attenuates the Brain Penetration of the PARP Inhibitor AZD2461. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30275858&form=6&db=m Expression of DNA Damage Response Proteins and Associations with Clinicopathologic Characteristics in Chinese Familial Breast Cancer Patients with BRCA1/2 Mutations. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30297533&form=6&db=m Targeting PARP1 in XRCC1 deficient sporadic invasive breast cancer or pre-invasive ductal carcinoma in situ induces synthetic lethality and chemoprevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30324586&form=6&db=m Pharmacokinetic Effects and Safety of Olaparib Administered with Endocrine Therapy: A Phase I Study in Patients with Advanced Solid Tumours. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30333000&form=6&db=m Response to olaparib in metastatic castration-resistant prostate cancer with germline BRCA2 mutation: a case report. causal interaction,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30333088&form=6&db=m PARP inhibitors in older patients with ovarian and breast cancer: Young International Society of Geriatric Oncology review paper. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30333750&form=6&db=m Network Pharmacology-Based Validation of Caveolin-1 as a Key Mediator of Ai Du Qing Inhibition of Drug Resistance in Breast Cancer. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30425352&form=6&db=m Long-term treatment with the PARP inhibitor niraparib does not increase the mutation load in cell line models and tumour xenografts. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30426062&form=6&db=m Pharmacokinetics and clinical response to single agent rucaparib in a dialysis dependent patient with BRCA associated breast and recurrent ovarian cancer. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30429212&form=6&db=m PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30442946&form=6&db=m PARP3, a new therapeutic target to alter Rictor/mTORC2 signaling and tumor progression in BRCA1-associated cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30499025&form=6&db=m p110? and p110? isoforms of PI3K are involved in protection against H2O2 induced oxidative stress in cancer cells. ongoing research,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30518089&form=6&db=m Role of BRCA Mutations in Cancer Treatment with Poly(ADP-ribose) Polymerase (PARP) Inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30520757&form=6&db=m Translational highlights in breast cancer research and treatment: recent developments with clinical impact. therapeutic application,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30542378&form=6&db=m Inhibitors targeting CDK4/6, PARP and PI3K in breast cancer: a review. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30554948&form=6&db=m The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30621214&form=6&db=m Poly-ADP-Ribosylation of Estrogen Receptor-Alpha by PARP1 Mediates Antiestrogen Resistance in Human Breast Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30647872&form=6&db=m Overexpression of PARP is an independent prognostic marker for poor survival in Middle Eastern breast cancer and its inhibition can be enhanced with embelin co-treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30662357&form=6&db=m GALNT6 Promotes Tumorigenicity and Metastasis of Breast Cancer Cell via ?-catenin/MUC1-C Signaling Pathway. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30663191&form=6&db=m Pharmacologic characterization of fluzoparib, a novel poly(ADP-ribose) polymerase inhibitor undergoing clinical trials. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30672063&form=6&db=m BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30726707&form=6&db=m Corrigendum to "Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization" [Nanomedicine 12 (3) (2016), 745-757]. ongoing research,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30786684&form=6&db=m BRCA1 and PARP1 mRNA expression during progression from normal breast to ductal carcinoma in situ and invasive breast cancer: a laser microdissection study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30789866&form=6&db=m Integrating poly(ADP-ribose) polymerase (PARP) inhibitors in the treatment of early breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30873673&form=6&db=m Cationic liposome codelivering PI3K pathway regulator improves the response of BRCA1-deficient breast cancer cells to PARP1 inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30880072&form=6&db=m Olaparib and ?-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30912451&form=6&db=m Advances in the use of PARP inhibitors for BRCA1/2-associated breast cancer: talazoparib. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30934991&form=6&db=m PARP Inhibitors as a Therapeutic Agent for Homologous Recombination Deficiency in Breast Cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30962720&form=6&db=m A systematic review of international guidelines and recommendations for the genetic screening, diagnosis, genetic counseling, and treatment of BRCA-mutated breast cancer. therapeutic application,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30973715&form=6&db=m [18F]-SuPAR: A Radiofluorinated Probe for Noninvasive Imaging of DNA Damage-Dependent Poly(ADP-ribose) Polymerase Activity. therapeutic application,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30989461&form=6&db=m Downregulation of APE1 potentiates breast cancer cells to olaparib by inhibiting PARP-1 expression. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31080552&form=6&db=m Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31099622&form=6&db=m Molecular Testing in Breast Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31151842&form=6&db=m Therapeutic innovations in breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31181965&form=6&db=m Exploiting DNA repair defects in breast cancer: from chemotherapy to immunotherapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31182917&form=6&db=m Prospect for Application of PARP Inhibitor in Patients with HER2 Negative Breast Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31191001&form=6&db=m Current status and future prospects of PARP inhibitor clinical trials in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31261939&form=6&db=m A Comparative Study of the Anticancer Activity and PARP-1 Inhibiting Effect of Benzofuran-Pyrazole Scaffold and Its Nano-Sized Particles in Human Breast Cancer Cells. ongoing research,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31288058&form=6&db=m Association of PARP1 rs4653734, rs907187 and rs1136410 variants with breast cancer risk among Iranian women. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31296812&form=6&db=m [Hereditary Breast and Ovarian Cancer Syndrome]. therapeutic application,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31300611&form=6&db=m Activation of HIF-1? by ?-Opioid Receptors Induces COX-2 Expression in Breast Cancer Cells and Leads to Paracrine Activation of Vascular Endothelial Cells. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31303769&form=6&db=m Evidence to date: talazoparib in the treatment of breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31304797&form=6&db=m Olaparib in germline-mutated metastatic breast cancer: implications of the OlympiAD trial. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31344602&form=6&db=m Targeting DNA repair in breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31413177&form=6&db=m PARP1 Inhibition Radiosensitizes Models of Inflammatory Breast Cancer to Ionizing Radiation. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31442685&form=6&db=m Discovery of novel functionalized 1,2,4-triazoles as PARP-1 inhibitors in breast cancer: Design, synthesis and antitumor activity evaluation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31489353&form=6&db=m Chemical characterization and biological activity data for a novel indirubin derivative, LDD-1819. ongoing research,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31499327&form=6&db=m Functional profiling of nucleotide Excision repair in breast cancer. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31500199&form=6&db=m The Role of PARPs in Inflammation-and Metabolic-Related Diseases: Molecular Mechanisms and Beyond. causal interaction,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31534547&form=6&db=m A nano-liposome formulation of the PARP inhibitor Talazoparib enhances treatment efficacy and modulates immune cell populations in mammary tumors of BRCA-deficient mice. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31537627&form=6&db=m Next-generation sequencing-based BRCA testing on cytological specimens from ovarian cancer ascites reveals high concordance with tumour tissue analysis. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31538027&form=6&db=m Olaparib: A Novel Therapy for Metastatic Breast Cancer in Patients With a BRCA1/2 Mutation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31540486&form=6&db=m Should Tumor Infiltrating Lymphocytes, Androgen Receptor, and FOXA1 Expression Predict the Clinical Outcome in Triple Negative Breast Cancer Patients? diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31575654&form=6&db=m Amplification of the Mutation-Carrying BRCA2 Allele Promotes RAD51 Loading and PARP Inhibitor Resistance in the Absence of Reversion Mutations. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31591209&form=6&db=m DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31614656&form=6&db=m PARP1 Co-Regulates EP300-BRG1-Dependent Transcription of Genes Involved in Breast Cancer Cell Proliferation and DNA Repair. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31625002&form=6&db=m PARP Inhibition in Cancer: An Update on Clinical Development. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31650446&form=6&db=m Veliparib in ovarian cancer: a new synthetically lethal therapeutic approach. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31695491&form=6&db=m TCDD-Inducible Poly-ADP-Ribose Polymerase (TIPARP), A Novel Therapeutic Target Of Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31735020&form=6&db=m Increased Expression of FosB through Reactive Oxygen Species Accumulation Functions as Pro-Apoptotic Protein in Piperlongumine Treated MCF7 Breast Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31753490&form=6&db=m Non-small cell lung cancer cells with deficiencies in homologous recombination genes are sensitive to PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31754897&form=6&db=m Targeted Therapies for Triple-Negative Breast Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31776133&form=6&db=m Gain-of-Function Mutant p53 R273H Interacts with Replicating DNA and PARP1 in Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31784542&form=6&db=m Isodeoxyelephantopin, a Sesquiterpene Lactone Induces ROS Generation, Suppresses NF-?B Activation, Modulates LncRNA Expression and Exhibit Activities Against Breast Cancer. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31815182&form=6&db=m Response to Olaparib in a Patient with Germline BRCA2 Mutation and Breast Cancer Leptomeningeal Carcinomatosis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31823331&form=6&db=m Poly (ADP-ribose) Polymerase Inhibition in Patients with Breast Cancer and BRCA 1 and 2 Mutations. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31933782&form=6&db=m Function and mechanism of combined PARP-1 and BRCA genes in regulating the radiosensitivity of breast cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31989039&form=6&db=m CRISPR/Cas9-mediated mutagenesis to validate the synergy between PARP1 inhibition and chemotherapy in BRCA1-mutated breast cancer cells. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32001817&form=6&db=m Coordinated signals from PARP-1 and PARP-2 are required to establish a proper T cell immune response to breast tumors in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32017532&form=6&db=m Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. therapeutic application,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32029455&form=6&db=m PARP and PARG inhibitors in cancer treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32040686&form=6&db=m The implications of BRCA loss of heterozygosity (LOH) and deficient mismatch repair gene (dMMR) expression in the breast cancer of a patient with both inherited breast and ovarian cancer syndrome (BRCA2) and Lynch syndrome (MLH1). therapeutic application,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32048546&form=6&db=m Identifying new piperazine-based PARP1 inhibitors using text mining and integrated molecular modeling approaches. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32055930&form=6&db=m Phase I and pharmacokinetic study of veliparib, a PARP inhibitor, and pegylated liposomal doxorubicin (PLD) in recurrent gynecologic cancer and triple negative breast cancer with long-term follow-up. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32057845&form=6&db=m BTH-8, a novel poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor, causes DNA double-strand breaks and exhibits anticancer activities in vitro and in vivo. therapeutic application,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32073315&form=6&db=m ADP ribose polymerase inhibitors for treating non-small cell lung cancer: new additions to the pharmacotherapeutic armamentarium. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32158196&form=6&db=m Metabolic Stability Assessment of New PARP Inhibitor Talazoparib Using Validated LC-MS/MS Methodology: In silico Metabolic Vulnerability and Toxicity Studies. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32164505&form=6&db=m A Review on Poly (ADP-ribose) Polymerase (PARP) Inhibitors and Synthetic Methodologies. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32166000&form=6&db=m Both BRCA1-wild type and -mutant triple-negative breast cancers show sensitivity to the NAE inhibitor MLN4924 which is enhanced upon MLN4924 and cisplatin combination treatment. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32171277&form=6&db=m Polyclonal BRCA2 mutations following carboplatin treatment confer resistance to the PARP inhibitor rucaparib in a patient with mCRPC: a case report. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32193285&form=6&db=m Inactivation of the prolyl isomerase Pin1 sensitizes BRCA1-proficient breast cancer to PARP inhibition. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32194151&form=6&db=m Dramatic response to PARP inhibition in a PALB2-mutated breast cancer: moving beyond BRCA. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32195033&form=6&db=m Blocking c-Met and EGFR reverses acquired resistance of PARP inhibitors in triple-negative breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32200503&form=6&db=m CUDC-907 enhances TRAIL-induced apoptosis through upregulation of DR5 in breast cancer cells. therapeutic application,unassigned 2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32201536&form=6&db=m Systems biology approaches based discovery of a small molecule inhibitor targeting both c-Met/PARP-1 and inducing cell death in breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32203254&form=6&db=m Knowledge and attitude of hereditary breast cancer among Japanese university female students. diagnostic usage,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32215876&form=6&db=m Poly (ADP-Ribose) Polymerase Inhibitors: Talazoparib in Ovarian Cancer and Beyond. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32221289&form=6&db=m Differential regulation of breast cancer bone metastasis by PARP1 and PARP2. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32235451&form=6&db=m Response of Breast Cancer Cells to PARP Inhibitors Is Independent of BRCA Status. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32241645&form=6&db=m [Hereditary breast carcinomas pathologist's perspective]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32245699&form=6&db=m Reversion and non-reversion mechanisms of resistance to PARP inhibitor or platinum chemotherapy in BRCA1/2-mutant metastatic breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32249776&form=6&db=m Pan-cancer analysis reveals synergistic effects of CDK4/6i and PARPi combination treatment in RB-proficient and RB-deficient breast cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32292575&form=6&db=m Inhibition of SYK kinase does not confer a pro-proliferative or pro-invasive phenotype in breast epithelium or breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32314111&form=6&db=m BRCA1 promoter methylation in breast cancer patients is associated with response to olaparib/eribulin combination therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32322108&form=6&db=m Update Breast Cancer 2020 Part 2 - Advanced Breast Cancer: New Treatments and Implementation of Therapies with Companion Diagnostics. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32345117&form=6&db=m Long non-coding RNA H19 regulates proliferation and doxorubicin resistance in MCF-7 cells by targeting PARP1. therapeutic application,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32357823&form=6&db=m Synthesis of Some Benzimidazole-derived Molecules and Their Effects on PARP-1 Activity and MDA-MB-231, MDA-MB-436, MDA-MB-468 Breast Cancer Cell Viability. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32373151&form=6&db=m Drug Targeting of Genomic Instability in Multiple Myeloma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32378669&form=6&db=m [Learning from My Experience: Outpatient Care for Cancer Multigene Genomic Testing]. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32394702&form=6&db=m Novel Poly(ADP-ribose) Polymerase-1 Inhibitor DDHCB Inhibits Proliferation of BRCA Mutant Breast Cancer Cell In Vitro and In Vivo through a Synthetic Lethal Mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32405340&form=6&db=m Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32455595&form=6&db=m Wise Management of Ovarian Cancer: On the Cutting Edge. causal interaction,diagnostic usage,unassigned 3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32455851&form=6&db=m Transcriptional Regulation of CCL2 by PARP1 Is a Driver for Invasiveness in Breast Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32471249&form=6&db=m PARP Inhibitors in the Treatment of Early Breast Cancer: The Step Beyond? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32471999&form=6&db=m Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32482023&form=6&db=m [New advances in targeted therapy for breast cancer]. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32488393&form=6&db=m Simple prediction model for homologous recombination deficiency in breast cancers in adolescents and young adults. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32508921&form=6&db=m Limitations of Systemic Oncological Therapy in Breast Cancer Patients with Chronic Kidney Disease. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32539467&form=6&db=m ABC4 Consensus: First Latin American Meeting-Assessment, Comments, and Application of Its Recommendations. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32563252&form=6&db=m PARP inhibitor resistance: the underlying mechanisms and clinical implications. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32597301&form=6&db=m Poly-(ADP-ribose) polymerase inhibitors: paradigm shift in the first-line treatment of newly diagnosed advanced ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32629278&form=6&db=m Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study. ongoing research,unassigned 2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32630796&form=6&db=m Zebrafish Xenografts Unveil Sensitivity to Olaparib beyond BRCA Status. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32633033&form=6&db=m Medical Management of newly diagnosed breast cancer in a BRCA1/2 mutation carrier. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32642648&form=6&db=m Efficacy and pharmacodynamics of niraparib in BRCA-mutant and wild-type intracranial triple-negative breast cancer murine models. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32657779&form=6&db=m Genomic landscape of metastatic breast cancer identifies preferentially dysregulated pathways and targets. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32717529&form=6&db=m The ups and downs of Poly(ADP-ribose) Polymerase-1 inhibitors in cancer therapy-Current progress and future direction. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32720162&form=6&db=m ?-hydroxyundec-9-enoic acid induction of breast cancer cells apoptosis through generation of mitochondrial ROS and phosphorylation of AMPK. ongoing research,unassigned 3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32726747&form=6&db=m Augmentation of the antitumor effects of PARP inhibitors in triple-negative breast cancer via degradation by hydrophobic tagging modulation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32768729&form=6&db=m Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32776290&form=6&db=m Actionable co-alterations in breast tumors with pathogenic mutations in the homologous recombination DNA damage repair pathway. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32796232&form=6&db=m Role of Poly (ADP-Ribose) Polymerase inhibitors beyond BReast CAncer Gene-mutated ovarian tumours: definition of homologous recombination deficiency? causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32811446&form=6&db=m PARP inhibitors combined with ionizing radiation induce different effects in melanoma cells and healthy fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32819114&form=6&db=m Optimizing the management of HER2-negative metastatic breast cancer in the era of PARP inhibitors-proceedings from breast cancer expert group meeting. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32852311&form=6&db=m Combining poly(ADP-ribose) polymerase inhibitors and immune checkpoint inhibitors in breast cancer: rationale and preliminary clinical results. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32903806&form=6&db=m Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer's Disease. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32920355&form=6&db=m Design and synthesis of some barbituric and 1,3-dimethylbarbituric acid derivatives: A non-classical scaffold for potential PARP1 inhibitors. ongoing research,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32923140&form=6&db=m Adoptive cell therapy of triple negative breast cancer with redirected cytokine-induced killer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32941897&form=6&db=m Application and reflection of genomic scar assays in evaluating the efficacy of platinum salts and PARP inhibitors in cancer therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32947878&form=6&db=m Withanolide C Inhibits Proliferation of Breast Cancer Cells via Oxidative Stress-Mediated Apoptosis and DNA Damage. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32947941&form=6&db=m Inhibition of DNA Repair Pathways and Induction of ROS Are Potential Mechanisms of Action of the Small Molecule Inhibitor BOLD-100 in Breast Cancer. therapeutic application,unassigned 2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32963576&form=6&db=m Cordyceps militaris Induces Immunogenic Cell Death and Enhances Antitumor Immunogenic Response in Breast Cancer. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32997669&form=6&db=m Effects of germline and somatic events in candidate BRCA-like genes on breast-tumor signatures. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33004179&form=6&db=m [PARP inhibitors in breast cancer: Current clinical development and perspectives]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33007379&form=6&db=m Survival benefits of PARP inhibitors in advanced breast cancer: a mirage? causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33010818&form=6&db=m Olaparib Suppresses MDSC Recruitment via SDF1?/CXCR4 Axis to Improve the Anti-tumor Efficacy of CAR-T Cells on Breast Cancer in Mice. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33071527&form=6&db=m Novel allosteric PARP1 inhibitors for the treatment of BRCA-deficient leukemia. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33087263&form=6&db=m Transcriptional dysregulation of base excision repair proteins in breast cancer. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33087787&form=6&db=m Low E2F2 activity is associated with high genomic instability and PARPi resistance. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33119476&form=6&db=m TBCRC 048: Phase II Study of Olaparib for Metastatic Breast Cancer and Mutations in Homologous Recombination-Related Genes. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33181269&form=6&db=m PARP inhibition in homologous-recombination-deficient early-stage breast cancer. therapeutic application,unassigned 2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33184404&form=6&db=m The diagnostic value of DNA repair gene in breast cancer metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33205541&form=6&db=m PARP1 and PRC2 double deficiency promotes BRCA-proficient breast cancer growth by modification of the tumor microenvironment. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33231937&form=6&db=m New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33233320&form=6&db=m Therapeutic Potential of PARP Inhibitors in the Treatment of Metastatic Castration-Resistant Prostate Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33242536&form=6&db=m Olaparib monotherapy as primary treatment in unselected triple negative breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33247475&form=6&db=m Homologous recombination deficiency in breast cancer: Implications for risk, cancer development, and therapy. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33257598&form=6&db=m Comparative efficacy, safety, and acceptability of single-agent poly (ADP-ribose) polymerase (PARP) inhibitors in BRCA-mutated HER2-negative metastatic or advanced breast cancer: a network meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33275824&form=6&db=m Development and evaluation of poly adenosine 5'-diphosphate-ribose polymerase 1 immobilization-based receptor chromatography. causal interaction,diagnostic usage,unassigned 3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33309164&form=6&db=m Discovery of novel PARP/PI3K dual inhibitors with high efficiency against BRCA-proficient triple negative breast cancer. therapeutic application,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33319340&form=6&db=m A real or apparent decrease in glomerular filtration rate in patients using olaparib? causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33336070&form=6&db=m A review of current progress in triple-negative breast cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33361107&form=6&db=m Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33384227&form=6&db=m Targeted Therapies for Breast Cancer Brain Metastases. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33425022&form=6&db=m XRCC1 deficient triple negative breast cancers are sensitive to ATR, ATM and Wee1 inhibitor either alone or in combination with olaparib. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33440946&form=6&db=m Integrating PARP inhibitors into the management of breast cancer: where are we? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33452192&form=6&db=m Randomised phase II trial of olaparib, chemotherapy or olaparib and cediranib in patients with platinum-resistant ovarian cancer (OCTOVA): a study protocol. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33468723&form=6&db=m [Effects of Olaparib, a PARP-1 Inhibitor, on Triple Negative Breast Cancer Cells with a BRCA1 Mutation]. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33475295&form=6&db=m PARP Inhibitors in Triple-Negative Breast Cancer Including Those With BRCA Mutations. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33494010&form=6&db=m DNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition. therapeutic application,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33520371&form=6&db=m Nuclear translocation of the receptor tyrosine kinase c-MET reduces the treatment efficacies of olaparib and gemcitabine in pancreatic ductal adenocarcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33532187&form=6&db=m Design, synthesis, and biological evaluation of quinazolin-4(3H)-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33541181&form=6&db=m Deep exploration of PARP inhibitors in breast cancer: monotherapy and combination therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33570247&form=6&db=m Efficacy of PARP inhibition combined with EZH2 inhibition depends on BRCA mutation status and microenvironment in breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33578357&form=6&db=m Clinical practice guidelines for BRCA1 and BRCA2 genetic testing. diagnostic usage,therapeutic application,unassigned 2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33598329&form=6&db=m Current and Future Directions for PARP Inhibition. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33617965&form=6&db=m Estrogen enhances the cytotoxicity of PARP inhibitors on breast cancer cells through stimulating nitric oxide production. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33627685&form=6&db=m A phase I dose-finding, pharmacokinetics and genotyping study of olaparib and lurbinectedin in patients with advanced solid tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33646064&form=6&db=m Perspectives on PARP inhibitors as pharmacotherapeutic strategies for breast cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33652085&form=6&db=m Blocking Fra-1 sensitizes triple-negative breast cancer to PARP inhibitor. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33710534&form=6&db=m An Overview of PARP Inhibitors for the Treatment of Breast Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33767780&form=6&db=m The role of novel poly (ADP-ribose) inhibitors in the treatment of locally advanced and metastatic Her-2/neu negative breast cancer with inherited germline BRCA1/2 mutations. A review of the literature. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33784822&form=6&db=m PARP inhibitor treatment of advanced breast cancer beyond the BRCA-mutated type: a meta-analysis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33812473&form=6&db=m Breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33832512&form=6&db=m Efficacy and mechanism of the combination of PARP and CDK4/6 inhibitors in the treatment of triple-negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33852339&form=6&db=m PARP Inhibitor in Platinum-Resistant Ovarian Cancer: Single-Center Real-World Experience. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33868586&form=6&db=m Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33884961&form=6&db=m In vivo visualization of PARP inhibitor pharmacodynamics. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33886122&form=6&db=m PARP (Poly ADP-Ribose Polymerase) inhibitors for locally advanced or metastatic breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33894017&form=6&db=m A Population Pharmacokinetic Meta-Analysis of Veliparib, a PARP Inhibitor, Across Phase 1/2/3 Trials in Cancer Patients. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33922595&form=6&db=m The PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33925616&form=6&db=m Genomic Correlates of DNA Damage in Breast Cancer Subtypes. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33940596&form=6&db=m Systematic comparison of ligand-based and structure-based virtual screening methods on poly (ADP-ribose) polymerase-1 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33952453&form=6&db=m Synergistic Effect of Bazedoxifene and PARP Inhibitor in the Treatment of Ovarian Cancer Regardless of BRCA Mutation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33959007&form=6&db=m Cost-Effectiveness Analysis of Olaparib Maintenance Treatment for Germline BRCA-Mutated Metastatic Pancreatic Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33966140&form=6&db=m High BRCA2 Gene Expression is Associated with Aggressive and Highly Proliferative Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33983578&form=6&db=m DNA Damage Repair Inhibitor for Breast Cancer Treatment. causal interaction,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33984694&form=6&db=m PARP inhibitor olaparib has a potential to increase the effectiveness of electrochemotherapy in BRCA1 mutated breast cancer in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33995588&form=6&db=m Prolonged response to treatment based on cell-free DNA analysis and molecular profiling in three patients with metastatic cancer: a case series. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33999036&form=6&db=m Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging. unassigned - 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34020277&form=6&db=m Synthesis, biological evaluation and molecular docking studies of novel 1,2,3-triazole-quinazolines as antiproliferative agents displaying ERK inhibitory activity. causal interaction,unassigned 1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34080025&form=6&db=m MAPK4 silencing together with a PARP1 inhibitor as a combination therapy in triple?negative breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34130011&form=6&db=m Evaluation of efficacy and safety of PARP inhibitors in breast cancer: A systematic review and meta-analysis. therapeutic application,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34136083&form=6&db=m Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34143979&form=6&db=m Durvalumab with olaparib and paclitaxel for high-risk HER2-negative stage II/III breast cancer: Results from the adaptively randomized I-SPY2 trial. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34158394&form=6&db=m PARP-1 Regulates Estrogen-Dependent Gene Expression in Estrogen Receptor ?-Positive Breast Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34213658&form=6&db=m Clinical trial data and emerging immunotherapeutic strategies: hormone receptor-positive, HER2- negative breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34231369&form=6&db=m Indirect treatment comparison of olaparib and talazoparib in germline BRCA-mutated HER2-negative metastatic breast cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34309133&form=6&db=m Rapid Progression of Metastatic Pancreatic Adenocarcinoma During Platinum-Based Therapy in a Patient Harboring a Pathogenic BRCA2 Germline Variant. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34309473&form=6&db=m Development of the PARP inhibitor talazoparib for the treatment of advanced BRCA1 and BRCA2 mutated breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34343058&form=6&db=m Adjuvant PARP Inhibitors in Patients With High-Risk Early-Stage HER2-Negative Breast Cancer and Germline BRCA Mutations: ASCO Hereditary Breast Cancer Guideline Rapid Recommendation Update. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34346034&form=6&db=m Molecular targeted drugs resistance impairs double-strand break repair and sensitizes ER-positive breast cancer to PARP inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34356606&form=6&db=m Dual PARP and RAD51 Inhibitory Drug Conjugates Show Synergistic and Selective Effects on Breast Cancer Cells. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34360649&form=6&db=m Moving beyond PARP Inhibition: Current State and Future Perspectives in Breast Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34420190&form=6&db=m Correction to: Molecular targeted drugs resistance impairs double?strand break repair and sensitizes ER?positive breast cancer to PARP inhibitors. therapeutic application,unassigned 4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34430738&form=6&db=m Anticancer activity of RAPTA-EA1 in triple-negative BRCA1 proficient breast cancer cells: single and combined treatment with the PARP inhibitor olaparib. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34439286&form=6&db=m Recent Advances in Enhancing the Therapeutic Index of PARP Inhibitors in Breast Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34455227&form=6&db=m Efficacy and safety of PARP inhibitors in patients with BRCA-mutated advanced breast cancer: A meta-analysis and systematic review. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34456966&form=6&db=m Identification of BRCA2 Cis Double Heterozygous Breast Cancer Cases Using Whole Exome Sequencing: Phenotypic Expression and Impact on Personalized Oncology. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34504648&form=6&db=m Selinexor, a selective inhibitor of nuclear export, enhances the anti-tumor activity of olaparib in triple negative breast cancer regardless of BRCA1 mutation status. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34539418&form=6&db=m ?-Mangostin Induces Apoptosis and Inhibits Metastasis of Breast Cancer Cells via Regulating RXR?-AKT Signaling Pathway. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Bronchiolitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19725100&form=6&db=m Fulminant pertussis: a multi-center study with new insights into the clinico-pathological mechanisms. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9918821&form=6&db=m Prolongation of the p53 response to DNA strand breaks in cells depleted of PARP by antisense RNA expression. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20503272&form=6&db=m The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma. unassigned - 2.4.2.30 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21227702&form=6&db=m Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents. therapeutic application,unassigned 4,0 2.4.2.30 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21365766&form=6&db=m Biological Effects of MC2050, a Quinazoline-Based PARP-1 Inhibitor, in Human Neuroblastoma and EBV-Positive Burkitt's Lymphoma Cells. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21590040&form=6&db=m Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28634224&form=6&db=m IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30395643&form=6&db=m Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33952464&form=6&db=m PARP1 Is Overexpressed in Hematological Malignant Cell Lines: A Framework for Experimental Oncology. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.4.2.30 Calcinosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32856128&form=6&db=m Calcinosis in Systemic Sclerosis: Updates in Pathophysiology, Evaluation, and Treatment. unassigned - 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3133126&form=6&db=m Inhibition of methylazoxymethanol acetate initiation of colon carcinogenesis in rats by treatment with the poly(ADP-ribose)polymerase inhibitor 3-aminobenzamide. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6140258&form=6&db=m Possible role of poly(ADP-ribose) polymerase on the early stage of liver carcinogenesis by diethylnitrosamine in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6145526&form=6&db=m Enhancement of DEN initiation of liver carcinogenesis by inhibitors of NAD+ ADP ribosyl transferase in rats. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,3,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7898479&form=6&db=m Poly(ADP-ribose) polymerase gene on chromosome 1q: early role in differentiation linked replication; gene on human chromosome 13q: marker of carcinogenesis. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8657188&form=6&db=m The beneficial effects of dietary restriction: reduced oxidative damage and enhanced apoptosis. unassigned - 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9398855&form=6&db=m Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis. unassigned - 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10597301&form=6&db=m Overexpression of dominant negative PARP interferes with tumor formation of HeLa cells in nude mice: evidence for increased tumor cell apoptosis in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11159733&form=6&db=m Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11359911&form=6&db=m DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11376691&form=6&db=m Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11376692&form=6&db=m Involvement of poly(ADP-ribose) polymerase in trophoblastic cell differentiation during tumorigenesis. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11432840&form=6&db=m Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice. causal interaction,unassigned 3,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11781113&form=6&db=m Poly(ADP-ribose) polymerase: a guardian angel protecting the genome and suppressing tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11781827&form=6&db=m Inhibition of poly(ADP-ribose) polymerase activity accelerates T-cell lymphomagenesis in p53 deficient mice. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11864456&form=6&db=m [DNA damage in human peripheral blood lymphocyte caused by nickel and cadmium] causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824873&form=6&db=m Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane. causal interaction,unassigned 3,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14726664&form=6&db=m Defective control of mitotic and post-mitotic checkpoints in poly(ADP-ribose) polymerase-1(-/-) fibroblasts after mitotic spindle disruption. causal interaction,unassigned 3,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15077172&form=6&db=m Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15081900&form=6&db=m Tannins elevate the level of poly(ADP-ribose) in HeLa cell extracts. causal interaction,unassigned 1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15545322&form=6&db=m Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15582275&form=6&db=m Poly(ADP-ribosyl)ation and aging. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15657079&form=6&db=m Mechanism of early biphasic activation of poly(ADP-ribose) polymerase-1 in response to ultraviolet B radiation. causal interaction,unassigned 3,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15709096&form=6&db=m Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15743677&form=6&db=m The emerging role of poly(ADP-ribose) polymerase-1 in longevity. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15777284&form=6&db=m Regulation of the poly(ADP-ribose) polymerase-1 gene expression by the transcription factors Sp1 and Sp3 is under the influence of cell density in primary cultured cells. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15927365&form=6&db=m Ex vivo study of MAPK profiles correlated with parameters of apoptosis during cervical carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15940627&form=6&db=m Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15955622&form=6&db=m Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16052507&form=6&db=m PARP-1-dependent 3-nitrotyrosine protein modification after DNA damage. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16338061&form=6&db=m Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16740713&form=6&db=m Inhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809031&form=6&db=m Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17003407&form=6&db=m Expression of the Gene Encoding Poly(ADP-ribose) Polymerase-1 Is Modulated by Fibronectin during Corneal Wound Healing. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17160013&form=6&db=m Poly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17504138&form=6&db=m Modulation of transcription by PARP-1: consequences in carcinogenesis and inflammation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17560163&form=6&db=m Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17645773&form=6&db=m PolyADP-ribosylation and cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18266822&form=6&db=m Cyclooxygenase-2 inhibitor nimesulide blocks ultraviolet B-induced photocarcinogenesis in SKH-1 hairless mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18306694&form=6&db=m [Poly(ADP-ribosa)polymerase--the relationships with life span and carcinogenesis] causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18558578&form=6&db=m Poly(ADP-ribose)polymerase-1 (PARP-1) in carcinogenesis: potential role of PARP inhibitors in cancer treatment. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19415146&form=6&db=m Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19458912&form=6&db=m The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis. ongoing research,unassigned 2,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20020658&form=6&db=m [Diethylnitrosamine-induced carcinogenesis in PARP-1(-/-) and PARP-1(+/+) mice] ongoing research,unassigned 2,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20034026&form=6&db=m Inhibition of poly adenosine diphosphate-ribose polymerase decreases hepatocellular carcinoma growth by modulation of tumor-related gene expression. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20804055&form=6&db=m [Features of carcinogenesis and aging in knockout male mice PARP-1] ongoing research,unassigned 4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21469519&form=6&db=m PARP-1 activity in normal and cancerous human endometrium and its relationship with quantity of abasic sites (AP). ongoing research,unassigned 2,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21543585&form=6&db=m Asbestos exposure affects poly(ADP-ribose) polymerase-1 activity: role in asbestos-induced carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21779467&form=6&db=m Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21911376&form=6&db=m Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family. causal interaction,unassigned 4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22127734&form=6&db=m Association between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22343235&form=6&db=m Molecular/Genetic therapies in ovarian cancer: future opportunities and challenges. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22387748&form=6&db=m Poly(ADP-ribose) polymerase-1 inhibition by arsenite promotes the survival of cells with unrepaired DNA lesions induced by UV exposure. causal interaction,unassigned 2,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22454210&form=6&db=m Expression of BAG-1 and PARP-1 in Precursor Lesions and Invasive Cervical Cancer Associated with Human Papillomavirus (HPV). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22614020&form=6&db=m PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis. therapeutic application,unassigned 1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23178280&form=6&db=m Modulation of farnesoid X receptor results in post-translational modification of poly (ADP-ribose) polymerase 1 in the liver. unassigned - 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23238565&form=6&db=m Loss of PIDD limits NF-?B activation and cytokine production but not cell survival or transformation after DNA damage. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23832774&form=6&db=m Transcript response of soft coral (Scleronephthya gracillimum) on exposure to polycyclic aromatic hydrocarbons. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23957916&form=6&db=m Parp-1 deficiency in ES cells promotes invasive and metastatic lesions accompanying induction of trophoblast giant cells during tumorigenesis in uterine environment. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24164298&form=6&db=m H2AX a promising biomarker for lung cancer: a review. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24203816&form=6&db=m Two DNA repair gene polymorphisms on the risk of gastrointestinal cancers: a meta-analysis. causal interaction,unassigned 3,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24350055&form=6&db=m Beyond DNA Repair: Additional Functions of PARP-1 in Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24386506&form=6&db=m Nicotinamide Phosphoribosyltransferase in Malignancy: A Review. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24726141&form=6&db=m The Histone Methyltransferase SMYD2 Methylates PARP1 and Promotes Poly(ADP-ribosyl)ation Activity in Cancer Cells. ongoing research,unassigned 2,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24853559&form=6&db=m PARP-1 Val762Ala polymorphism and risk of cancer: a meta-analysis based on 39 case-control studies. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24866151&form=6&db=m Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition. therapeutic application,unassigned 4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24889936&form=6&db=m Parp-1 genetic ablation in Ela-myc mice unveils novel roles for Parp-1 in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25173886&form=6&db=m PARP-1 regulates epithelial-mesenchymal transition (EMT) in prostate tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25268610&form=6&db=m Effect of APE1 T2197G (Asp148Glu) polymorphism on APE1, XRCC1, PARP1 and OGG1 expression in patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25555679&form=6&db=m RecQ helicases and PARP1 team up in maintaining genome integrity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,2 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25848691&form=6&db=m Functional Characterization of Long Noncoding RNA Lnc_bc060912 in Human Lung Carcinoma Cells. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26040766&form=6&db=m PARP3 interacts with FoxM1 to confer glioblastoma cell radioresistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26314963&form=6&db=m Inhibition of poly(ADP-ribose) polymerase 1 protects against acute myeloid leukemia by suppressing the myeloproliferative leukemia virus oncogene. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26383629&form=6&db=m Sulfur and nitrogen mustards induce characteristic poly(ADP-ribosyl)ation responses in HaCaT keratinocytes with distinctive cellular consequences. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26898760&form=6&db=m PARP1 enhances lung adenocarcinoma metastasis by novel mechanisms independent of DNA repair. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27373144&form=6&db=m Common and unique genetic interactions of the poly(ADP-ribose) polymerases PARP1 and PARP2 with DNA double-strand break repair pathways. ongoing research,unassigned 1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27409836&form=6&db=m Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27498558&form=6&db=m Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27656839&form=6&db=m Knockdown of PARP-1 Inhibits Proliferation and ERK Signals, Increasing Drug Sensitivity in Osteosarcoma U2OS Cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27694308&form=6&db=m Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27736844&form=6&db=m PARP inhibitors for BRCA1/2-mutated and sporadic ovarian cancer: current practice and future directions. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28481869&form=6&db=m The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression. unassigned - 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28510338&form=6&db=m Therapeutic Targeting of Poly(ADP-Ribose) Polymerase-1 (PARP1) in Cancer: Current Developments, Therapeutic Strategies, and Future Opportunities. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28714367&form=6&db=m PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29254138&form=6&db=m Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis. unassigned - 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29632181&form=6&db=m PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,1 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29862234&form=6&db=m Advanced small cell lung cancer (SCLC): new challenges and new expectations. unassigned - 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30032250&form=6&db=m PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30127774&form=6&db=m PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30183716&form=6&db=m Interaction among susceptibility genotypes of PARP1 SNPs in thyroid carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,2 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30614530&form=6&db=m Cytoplasmic PARP-1 promotes pancreatic cancer tumorigenesis and resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30880062&form=6&db=m Non-NAD-like PARP-1 inhibitors in prostate cancer treatment. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30968979&form=6&db=m PARP14 promotes the proliferation and gemcitabine chemoresistance of pancreatic cancer cells through activation of NF-?B pathway. causal interaction,unassigned 2,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31116084&form=6&db=m DNA double-strand break repair pathway choice - from basic biology to clinical exploitation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31609976&form=6&db=m Modulation of brain tumor risk by genetic SNPs in PARP1gene: Hospital based case control study. causal interaction,ongoing research,unassigned 2,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31720442&form=6&db=m Chemopreventive effect of hesperidin, a citrus bioflavonoid in two stage skin carcinogenesis in Swiss albino mice. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32482854&form=6&db=m TiPARP forms nuclear condensates to degrade HIF-1? and suppress tumorigenesis. unassigned - 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33112558&form=6&db=m PARP1 Gene Polymorphisms and the Prognosis of Esophageal Cancer Patients from Cixian High-Incidence Region in Northern China. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33231937&form=6&db=m New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33284833&form=6&db=m Association of PARP1-specific polymorphisms and haplotypes with non-small cell lung cancer subtypes. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,1,1 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33495297&form=6&db=m Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1 immunotherapy in colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33671256&form=6&db=m Identification and Characterization of MortaparibPlus-A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and -Independent Mechanisms. causal interaction,unassigned 3,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33805293&form=6&db=m The Significance of Targeting Poly (ADP-Ribose) Polymerase-1 in Pancreatic Cancer for Providing a New Therapeutic Paradigm. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34406176&form=6&db=m PARP1 rs1136410 (A/G) polymorphism is associated with early age of onset of gallbladder cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19765735&form=6&db=m MG-132 Inhibits Carcinoid Growth and Alters the Neuroendocrine Phenotype. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27632933&form=6&db=m The PARP inhibitor ABT-888 potentiates dacarbazine-induced cell death in carcinoids. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3081939&form=6&db=m Poly(ADP-ribose) polymerase activity in proliferating and quiescent murine mammary carcinoma cells. unassigned - 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3133329&form=6&db=m Differential radiosensitization by the poly(ADP-ribose) transferase inhibitor 3-aminobenzamide in human tumor cells of varying radiosensitivity. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8527492&form=6&db=m Reversion of malignant phenotype by 5-iodo-6-amino-1,2-benzopyrone a non-covalently binding ligand of poly(ADP-ribose) polymerase. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8821710&form=6&db=m Effects of pertussis toxin on signal transductions via P2-purinergic receptors in A-431 human epidermoidal carcinoma cells. ongoing research,unassigned 4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9040540&form=6&db=m Male rats fed methyl- and folate-deficient diets with or without niacin develop hepatic carcinomas associated with decreased tissue NAD concentrations and altered poly(ADP-ribose) polymerase activity. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9439682&form=6&db=m Levels of superoxide dismutases, glutathione, and poly(ADP-ribose) polymerase in radioresistant human KB carcinoma cell line. ongoing research,unassigned 4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9920281&form=6&db=m Prevention of oxidant-induced cell death in Caco-2 colon carcinoma cells after inhibition of poly(ADP-ribose) polymerase and Ca2+ chelation: involvement of a common mechanism. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11133044&form=6&db=m Poly(ADP-ribose) polymerase, a major determinant of early cell response to ionizing radiation. ongoing research,unassigned 4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11162590&form=6&db=m Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11359911&form=6&db=m DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11494028&form=6&db=m Expression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11956622&form=6&db=m Poly(ADP-ribose) polymerase turnover alterations do not contribute to PARP overexpression in Ewing's sarcoma cells. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11973636&form=6&db=m MBP-1 mediated apoptosis involves cytochrome c release from mitochondria. ongoing research,unassigned 2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12007281&form=6&db=m Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12111185&form=6&db=m Influence of pertussis toxin on superficial bladder carcinoma in rats. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12382020&form=6&db=m PK11195, an isoquinoline carboxamide ligand of the mitochondrial benzodiazepine receptor, increased drug uptake and facilitated drug-induced apoptosis in human multidrug-resistant leukemia cells in vitro. ongoing research,unassigned 3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12700281&form=6&db=m Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12820412&form=6&db=m Intrinsic presence of poly (ADP-ribose) is significantly increased in malignant prostate compared to benign prostate cell lines. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12851702&form=6&db=m Sodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12855651&form=6&db=m Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies. ongoing research,unassigned 3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12907245&form=6&db=m The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide. ongoing research,unassigned 3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14961567&form=6&db=m Poly(ADP-ribose) polymerase-1, a novel partner of progesterone receptors in endometrial cancer and its precursors. causal interaction,diagnostic usage,unassigned 3,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15117815&form=6&db=m Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15289867&form=6&db=m Flavone inhibition of tumor growth via apoptosis in vitro and in vivo. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16338061&form=6&db=m Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16505115&form=6&db=m c-Abl-independent p73 stabilization during gemcitabine- or 4'-thio-{beta}-D-arabinofuranosylcytosine-induced apoptosis in wild-type and p53-null colorectal cancer cells. therapeutic application,unassigned 3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809434&form=6&db=m Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17160013&form=6&db=m Poly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17214747&form=6&db=m Evidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17258405&form=6&db=m Poly(ADP-ribose) polymerase (PARP) and DNA-fragmentation factor (DFF45): expression and correlation in normal, hyperplastic and neoplastic endometrial tissues. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17413981&form=6&db=m Poly(adenosine diphosphate-ribose) polymerase expression in serous ovarian carcinoma: correlation with p53, MIB-1, and outcome. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17562258&form=6&db=m [Inhibitory effect of 5-aminoisoquinolinone on PARP activity in colon carcinoma cell line HT-29] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17614107&form=6&db=m Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17617028&form=6&db=m Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18053169&form=6&db=m Comparative evaluation of antiproliferative, antiangiogenic and apoptosis inducing potential of black tea polyphenols in the hamster buccal pouch carcinogenesis model. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18607066&form=6&db=m Mitochondrial DNA depletion reduces PARP-1 levels and promotes progression of the neoplastic phenotype in prostate carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18660545&form=6&db=m PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18717684&form=6&db=m Deletions of BRCA1/2 and p53 R248W gain-of-function mutation suggest impaired homologous recombination repair in fragile histidine triad-negative sebaceous gland carcinomas. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18809672&form=6&db=m Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18989759&form=6&db=m Effect of Poly (ADP-ribose) Polymerase-1 Inhibition on the Proliferation of Murine Colon Carcinoma CT26 Cells. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19029405&form=6&db=m Assessment of apoptosis by immunohistochemistry to active caspase-3, active caspase-7, or cleaved PARP in monolayer cells and spheroid and subcutaneous xenografts of human carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19216720&form=6&db=m Spatiotemporal activation of caspase-dependent and -independent pathways in staurosporine-induced apoptosis of p53wt and p53mt human cervical carcinoma cells. unassigned - 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19468250&form=6&db=m Poly(ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20067769&form=6&db=m Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20196871&form=6&db=m PARP-1 Val762Ala polymorphism is associated with reduced risk of non-Hodgkin lymphoma in Korean males. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20362665&form=6&db=m Ras(V12) induces Survivin/AuroraB pathway conferring tumor cell apoptosis resistance. ongoing research,unassigned 3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20370684&form=6&db=m Pharmacological Inhibition of Poly(ADP-ribose) Polymerase (PARP) Activity in PARP-1 Silenced Tumour Cells Increases Chemosensitivity to Temozolomide and to a N3-Adenine Selective Methylating Agent. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20464779&form=6&db=m Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20683914&form=6&db=m Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy. ongoing research,unassigned 1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20696794&form=6&db=m Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20708052&form=6&db=m Antimicrobial cyclic decapeptides with anticancer activity. ongoing research,unassigned 4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20848107&form=6&db=m [Hereditary breast and ovarian cancers]. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20875401&form=6&db=m Poly(ADP-ribose) polymerase signaling of topoisomerase 1-dependent DNA damage in carcinoma cells. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21097693&form=6&db=m Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts. causal interaction,unassigned 1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21409392&form=6&db=m PARP-1 expression in breast cancer including BRCA1-associated, triple negative and basal-like tumors: possible implications for PARP-1 inhibitor therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21508395&form=6&db=m Evidence for the efficacy of Iniparib, a PARP-1 inhibitor, in BRCA2-associated pancreatic cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21644054&form=6&db=m PARP1 and CASP3 gene expression in a patient with multiple head and neck squamous cell carcinoma and Parkinson disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21692479&form=6&db=m Discovery and Structure-Activity Relationships of Modified Salicylanilides as Cell Permeable Inhibitors of Poly(ADP-ribose) Glycohydrolase (PARG). causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21825006&form=6&db=m Inhibition of poly(ADP-ribose) polymerase-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22172724&form=6&db=m BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22269178&form=6&db=m Cisplatin benefit is predicted by immunohistochemical analysis of DNA repair proteins in squamous cell carcinoma but not adenocarcinoma: theranostic modeling by NSCLC constituent histological subclasses. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22304686&form=6&db=m New insights on the pathogenesis of ovarian carcinoma: molecular basis and clinical implications. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22315424&form=6&db=m Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22334019&form=6&db=m Radiation-inducible Immunotherapy for Cancer: Senescent Tumor Cells as a Cancer Vaccine. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22454210&form=6&db=m Expression of BAG-1 and PARP-1 in Precursor Lesions and Invasive Cervical Cancer Associated with Human Papillomavirus (HPV). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22591423&form=6&db=m The Role of PARP Inhibitors in the Treatment of Ovarian Carcinomas. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22596349&form=6&db=m Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in mammary tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22624032&form=6&db=m PARP-1 Val762Ala polymorphism is associated with risk of cervical carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22627996&form=6&db=m Xanthorrhizol Induces Apoptosis Through ROS-Mediated MAPK Activation in Human Oral Squamous Cell Carcinoma Cells and Inhibits DMBA-Induced Oral Carcinogenesis in Hamsters. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22879933&form=6&db=m c-Abl Is an Upstream Regulator of Acid Sphingomyelinase in Apoptosis Induced by Inhibition of Integrins ?v?3 and ?v?5. unassigned - 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22882088&form=6&db=m Overexpression of chromatin assembly factor-1 p60, poly(ADP-ribose) polymerase 1 and nestin predicts metastasizing behaviour of oral cancer. therapeutic application,unassigned 1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23087057&form=6&db=m Loss of PPP2R2A inhibits homologous recombination DNA repair and predicts tumor sensitivity to PARP inhibition. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23376119&form=6&db=m p63 involvement in poly(ADP-ribose) polymerase 1 signaling of topoisomerase I-dependent DNA damage in carcinoma cells. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23548133&form=6&db=m Systemic treatment for hereditary cancers: a 2012 update. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23570906&form=6&db=m Identification of miRNA modulators to PARP inhibitor response. causal interaction,unassigned 3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23574784&form=6&db=m Poly(adenosine diphosphate-ribose) polymerase expression in BRCA-proficient ovarian high-grade serous carcinoma; association with patient survival. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23652727&form=6&db=m Inhibition of arginine ADP-ribosyltransferase 1 reduces the expression of poly(ADP-ribose) polymerase-1 in colon carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23653048&form=6&db=m Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23917378&form=6&db=m PARP and CHK inhibitors interact to cause DNA damage and cell death in mammary carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24219164&form=6&db=m Effect of a poly(ADP-ribose) polymerase-1 inhibitor against esophageal squamous cell carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24336406&form=6&db=m Mitochondrial DNA depletion sensitizes cancer cells to PARP inhibitors by translational and post-translational repression of BRCA2. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24387284&form=6&db=m The La antigen is over-expressed in lung cancer and is a selective dead cancer cell target for radioimmunotherapy using the La-specific antibody APOMAB®. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24566325&form=6&db=m Triptolide induces s phase arrest and apoptosis in gallbladder cancer cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24595077&form=6&db=m Heterogeneous nuclear ribonucleoprotein U-like 1 and Poly (ADP-ribose) polymerase 1 are downregulated in renal cell carcinoma and connected with the prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24676941&form=6&db=m Synergistic effect of arginine-specific ADP-ribosyltransferase 1 and poly(ADP-ribose) polymerase-1 on apoptosis induced by cisplatin in CT26 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24714082&form=6&db=m Activity of CEP-9722, a poly (ADP-ribose) polymerase inhibitor, in urothelial carcinoma correlates inversely with homologous recombination repair response to DNA damage. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24735547&form=6&db=m Linifanib (ABT-869), enhances cytotoxicity with poly (ADP-ribose) polymerase inhibitor, veliparib (ABT-888), in head and neck carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24918927&form=6&db=m RIG-I enhanced interferon independent apoptosis upon Junin virus infection. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25324139&form=6&db=m Dual disruption of DNA repair and telomere maintenance for the treatment of head and neck cancer. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25526641&form=6&db=m PARP-1 expression is increased in colon adenoma and carcinoma and correlates with OGG1. causal interaction,diagnostic usage,unassigned 4,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25708226&form=6&db=m PARP inhibitors: A new era of targeted therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26169965&form=6&db=m Development of Olaparib for BRCA-Deficient Recurrent Epithelial Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26203587&form=6&db=m Tanshinone IIA Facilitates TRAIL Sensitization by Up-regulating DR5 through the ROS-JNK-CHOP Signaling Axis in Human Ovarian Carcinoma Cell Lines. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26318057&form=6&db=m Design, synthesis, and anticancer evaluation of long-chain alkoxylated mono-carbonyl analogues of curcumin. ongoing research,unassigned 2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26774475&form=6&db=m Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26808835&form=6&db=m Optical Imaging of PARP1 in Response to Radiation in Oral Squamous Cell Carcinoma. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26927065&form=6&db=m Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26941449&form=6&db=m PARP Inhibitors for Recurrent Ovarian Carcinoma: Current Treatment Options and Future Perspectives. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27362900&form=6&db=m The Prognostic Value of BRCA1 and PARP Expression in Epithelial Ovarian Carcinoma: Immunohistochemical Detection. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27473117&form=6&db=m Sam68 reduces cisplatin-induced apoptosis in tongue carcinoma. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27614696&form=6&db=m In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27644669&form=6&db=m Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27681719&form=6&db=m Anti-Cancer Effect of Quercetin in Xenograft Models with EBV-Associated Human Gastric Carcinoma. unassigned - 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27767231&form=6&db=m Novel BRCA1 and BRCA2 Tumor Test as Basis for Treatment Decisions and Referral for Genetic Counselling of Patients with Ovarian Carcinomas. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27869444&form=6&db=m [BRCA1 and BRCA2 - pathologists starting kit]. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27869446&form=6&db=m [Oncopathological aspects of BRCA1 and BRCA2 genes inactivation in tumors of ovary, fallopian tube and pelvic peritoneum]. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27908594&form=6&db=m Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28002809&form=6&db=m Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of ovarian clear cell cancer. therapeutic application,unassigned 4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28073364&form=6&db=m Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28264872&form=6&db=m A Phase I-II Study of the Oral Poly(ADP-ribose) Polymerase Inhibitor Rucaparib in Patients with Germline BRCA1/2-mutated Ovarian Carcinoma or Other Solid Tumors. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28392129&form=6&db=m Poly(ADP-ribose) polymerase (PARP) inhibitors as treatment versus maintenance in ovarian carcinoma. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28588062&form=6&db=m Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28625311&form=6&db=m - unassigned - 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28631774&form=6&db=m [Il ruolo di niraparib nel trattamento del carcinoma ovarico: attualità e prospettive.] unassigned - 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28789382&form=6&db=m Poly (ADP-ribose) polymerase-1 inhibition decreases proliferation through G2/M arrest in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28881569&form=6&db=m Aurora A kinase regulates non-homologous end-joining and poly(ADP-ribose) polymerase function in ovarian carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28882436&form=6&db=m Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,1 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28916367&form=6&db=m Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,4 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28991194&form=6&db=m PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29570891&form=6&db=m Poly ADP-ribose polymerase-1 as a potential therapeutic target in Merkel cell carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29617652&form=6&db=m Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas. therapeutic application,unassigned 2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29684820&form=6&db=m Increased oxidative stress mediates the antitumor effect of PARP inhibition in ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29771043&form=6&db=m [The effect of tanshinone ?A potentiates the effects of Cisplatin in Fadu cells in vitro through downregulation of survivin]. therapeutic application,unassigned 1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29923797&form=6&db=m Valproate augments Niraparib killing of tumor cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30024813&form=6&db=m The CHK1 inhibitor SRA737 synergizes with PARP1 inhibitors to kill carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30025822&form=6&db=m Radiosensitization by the PARP inhibitor olaparib in BRCA1-proficient and deficient high-grade serous ovarian carcinomas. causal interaction,unassigned 3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30209066&form=6&db=m The TLR7/8/9 antagonist IMO-8503 inhibits cancer-induced cachexia. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30266954&form=6&db=m Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30425037&form=6&db=m BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,2 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30447298&form=6&db=m Immunohistochemistry expression of targeted therapies biomarkers in ovarian clear cell and endometrioid carcinomas (type I) and endometriosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30540581&form=6&db=m Poly-ADP-ribosyl-polymerase inhibitor resistance mechanisms and their therapeutic implications. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30666631&form=6&db=m Antitumor efficacy of PARP inhibitors in homologous recombination deficient carcinomas. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30683677&form=6&db=m Prevalence of germline pathogenic BRCA1/2 variants in sequential epithelial ovarian cancer cases. causal interaction,unassigned 4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30864743&form=6&db=m PARG regulates the proliferation and differentiation of DCs and T cells via PARP/NF??B in tumour metastases of colon carcinoma. diagnostic usage,unassigned 2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30929564&form=6&db=m Targeted blockade of HSP90 impairs DNA-damage response proteins and increases the sensitivity of ovarian carcinoma cells to PARP inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31002019&form=6&db=m Pancreatic acinar cell carcinoma is associated with BRCA2 germline mutations: a case report and literature review. ongoing research,unassigned 1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31060523&form=6&db=m Genomic profiling in ovarian cancer retreated with platinum based chemotherapy presented homologous recombination deficiency and copy number imbalances of CCNE1 and RB1 genes. causal interaction,unassigned 3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31300704&form=6&db=m Fast dose fractionation using ultra-short laser accelerated proton pulses can increase cancer cell mortality, which relies on functional PARP1 protein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31337981&form=6&db=m The antipsychotic agent flupentixol is a new PI3K inhibitor and potential anticancer drug for lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31490091&form=6&db=m Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31686145&form=6&db=m Autophagy suppression enhances DNA damage and cell death upon treatment with PARP inhibitor Niraparib in laryngeal squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31742824&form=6&db=m Prevalence of hereditary breast and ovarian cancer (HBOC) predisposition gene mutations among 882 HBOC high-risk Chinese individuals. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31775874&form=6&db=m Histone methyltransferases EHMT1 and EHMT2 (GLP/G9A) maintain PARP inhibitor resistance in high-grade serous ovarian carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31812083&form=6&db=m Silencing of CHFR Sensitizes Gastric Carcinoma to PARP Inhibitor Treatment. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31827092&form=6&db=m BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31976528&form=6&db=m PARP inhibitor olaparib sensitizes esophageal carcinoma cells to fractionated proton irradiation. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32019284&form=6&db=m Clinical Impact of Somatic Variants in Homologous Recombination Repair-Related Genes in Ovarian High-Grade Serous Carcinoma. causal interaction,unassigned 1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32028808&form=6&db=m A profile on the FoundationFocus CDxBRCA tests. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32093123&form=6&db=m Synergistic Anti-Tumour Effect of Syk Inhibitor and Olaparib in Squamous Cell Carcinoma: Roles of Syk in EGFR Signalling and PARP1 Activation. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32139402&form=6&db=m PARP inhibition enhances radiotherapy of SMAD4 deficient human head and neck squamous cell carcinomas in experimental models. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32165735&form=6&db=m Validation of the use of a fluorescent PARP1 inhibitor for the detection of oral, oropharyngeal and oesophageal epithelial cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,4 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32636416&form=6&db=m Fluorescence-guided resection of tumors in mouse models of oral cancer. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32651552&form=6&db=m Mainstreaming germline BRCA1/2 testing in non-mucinous epithelial ovarian cancer in the North West of England. causal interaction,unassigned 4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32711558&form=6&db=m MAPK4 deletion enhances radiation effects and triggers synergistic lethality with simultaneous PARP1 inhibition in cervical cancer. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32757789&form=6&db=m Combination therapy in advanced urothelial cancer: the role of PARP, HER-2 and mTOR inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32936912&form=6&db=m Combined EGFR1 and PARP1 Inhibition Enhances the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Models. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33003546&form=6&db=m The RECAP Test Rapidly and Reliably Identifies Homologous Recombination-Deficient Ovarian Carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33004253&form=6&db=m ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33092495&form=6&db=m Cellular and biochemical antileukemic mechanisms of the meroterpenoid Oncocalyxone A. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33112558&form=6&db=m PARP1 Gene Polymorphisms and the Prognosis of Esophageal Cancer Patients from Cixian High-Incidence Region in Northern China. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33183998&form=6&db=m PARP inhibitors and radiation potentiate liver cell death in vitro. Do hepatocellular carcinomas have an achilles' heel? causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33287919&form=6&db=m Development of poly ADP-ribose polymerase-1 inhibitor with anti-cervical carcinoma activity. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33352687&form=6&db=m BRCA Methylation Testing Identifies a Subset of Ovarian Carcinomas without Germline Variants That Can Benefit from PARP Inhibitor. therapeutic application,unassigned 3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33417952&form=6&db=m PARP-1 induces EMT in non-small cell lung carcinoma cells via modulating the transcription factors Smad4, p65 and ZEB1. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33465522&form=6&db=m Promising anti- cervical carcinoma and inflammatory agent, Resveratrol targets poly (ADP-ribose) polymerase 1 (PARP-1) induced premature ovarian failure with a potent enzymatic modulatory activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,2 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33513474&form=6&db=m A phase I trial adding poly(ADP-ribose) polymerase inhibitor veliparib to induction carboplatin-paclitaxel in patients with head and neck squamous cell carcinoma: Alliance A091101. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33528729&form=6&db=m PARP1 rs1136410 C/C genotype associated with an increased risk of esophageal cancer in smokers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33741027&form=6&db=m Low expression of TRAF3IP2-AS1 promotes progression of NONO-TFE3 translocation renal cell carcinoma by stimulating N6-methyladenosine of PARP1 mRNA and downregulating PTEN. diagnostic usage,unassigned 1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33803654&form=6&db=m Epigenetic Treatment of Urothelial Carcinoma Cells Sensitizes to Cisplatin Chemotherapy and PARP Inhibitor Treatment. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33803939&form=6&db=m Candidate Markers of Olaparib Response from Genomic Data Analyses of Human Cancer Cell Lines. causal interaction,diagnostic usage,unassigned 4,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33926263&form=6&db=m Effect of PARP Inhibitors as Maintenance Treatment on Restricted Mean Survival Time in Platinum-Sensitive Recurrent Ovarian Cancer: A Systematic Review and Meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33941784&form=6&db=m Molecular and clinical determinants of response and resistance to rucaparib for recurrent ovarian cancer treatment in ARIEL2 (Parts 1 and 2). therapeutic application,unassigned 2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33995588&form=6&db=m Prolonged response to treatment based on cell-free DNA analysis and molecular profiling in three patients with metastatic cancer: a case series. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34030643&form=6&db=m Efficacy and safety of rucaparib in previously treated, locally advanced or metastatic urothelial carcinoma from a phase 2, open-label trial (ATLAS). causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,4 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34073906&form=6&db=m The DEAD/DEAH Box Helicase, DDX11, Is Essential for the Survival of Advanced Clear Cell Renal Cell Carcinoma and Is a Determinant of PARP Inhibitor Sensitivity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34123730&form=6&db=m Effect of cisplatin on metastatic castration-resistant prostate cancer with BRCA2 mutation: A case report. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34159897&form=6&db=m Exosome component 1 cleaves single-stranded DNA and sensitizes human kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34307148&form=6&db=m The Emerging Role of Poly (ADP-Ribose) Polymerase Inhibitors as Effective Therapeutic Agents in Renal Cell Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34321239&form=6&db=m Acquired RAD51C Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34323956&form=6&db=m Cytoplasmic EBP50 and elevated PARP1 are unfavorable prognostic factors in ovarian clear cell carcinoma. causal interaction,diagnostic usage,unassigned 3,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34356835&form=6&db=m Poly (ADP-Ribose) Polymerase Inhibitor, ABT888, Improved Cisplatin Effect in Human Oral Cell Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34475063&form=6&db=m Ovarian Serous Carcinoma With a Novel HSP90AB1 Mutation in a Patient With Synchronous Primary Fallopian Tube Serous Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34518240&form=6&db=m ATARI trial: ATR inhibitor in combination with olaparib in gynecological cancers with ARID1A loss or no loss (ENGOT/GYN1/NCRI). diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34521439&form=6&db=m Correction to: Low expression of TRAF3IP2-AS1 promotes progression of NONO-TFE3 translocation renal cell carcinoma by stimulating N6-methyladenosine of PARP1 mRNA and downregulating PTEN. diagnostic usage,unassigned 1,0 2.4.2.30 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Carcinoma, Acinar Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31002019&form=6&db=m Pancreatic acinar cell carcinoma is associated with BRCA2 germline mutations: a case report and literature review. ongoing research,unassigned 1,0 2.4.2.30 Carcinoma, Adenoid Cystic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33995588&form=6&db=m Prolonged response to treatment based on cell-free DNA analysis and molecular profiling in three patients with metastatic cancer: a case series. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18660545&form=6&db=m PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21779467&form=6&db=m Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21908496&form=6&db=m Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30297533&form=6&db=m Targeting PARP1 in XRCC1 deficient sporadic invasive breast cancer or pre-invasive ductal carcinoma in situ induces synthetic lethality and chemoprevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.4.2.30 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30786684&form=6&db=m BRCA1 and PARP1 mRNA expression during progression from normal breast to ductal carcinoma in situ and invasive breast cancer: a laser microdissection study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.4.2.30 Carcinoma, Ehrlich Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=188648&form=6&db=m Purification of poly(ADP-ribose) polymerase from Ehrlich ascites tumor cells by chromatography on DNA-agarose. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Carcinoma, Ehrlich Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=211029&form=6&db=m Poly(ADP-ribose) polymerase from Ehrlich ascites tumor cells. Properties of the purified polymerase. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Carcinoma, Ehrlich Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6144544&form=6&db=m NAD[S], an NAD analogue with reduced susceptibility to phosphodiesterase. Chemical synthesis and enzymic properties. diagnostic usage,unassigned 2,0 2.4.2.30 Carcinoma, Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23251575&form=6&db=m Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to Cisplatin and poly (adp-ribose) polymerase inhibition. therapeutic application,unassigned 4,0 2.4.2.30 Carcinoma, Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23486608&form=6&db=m PARP expression in germ cell tumours. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.4.2.30 Carcinoma, Endometrioid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17258405&form=6&db=m Poly(ADP-ribose) polymerase (PARP) and DNA-fragmentation factor (DFF45): expression and correlation in normal, hyperplastic and neoplastic endometrial tissues. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Carcinoma, Endometrioid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30447298&form=6&db=m Immunohistochemistry expression of targeted therapies biomarkers in ovarian clear cell and endometrioid carcinomas (type I) and endometriosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3029772&form=6&db=m Cloning and expression of cDNA for human poly(ADP-ribose) polymerase. ongoing research,unassigned 4,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3121314&form=6&db=m Poly(ADP-ribose) synthase is the major endogenous nonhistone acceptor for poly(ADP-ribose) in alkylated rat hepatoma cells. unassigned - 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9884343&form=6&db=m Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. unassigned - 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11016660&form=6&db=m Mechanism for the antitumor and anticachectic effects of n-3 fatty acids. ongoing research,unassigned 3,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11032362&form=6&db=m Induction of apoptosis in normal cultured rat hepatocytes and in Hep3B, a human hepatoma cell line. ongoing research,unassigned 3,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15284388&form=6&db=m Conjugated linoleic acid isomers and trans fatty acids inhibit fatty acid transport in hepatoma 7288CTC and inguinal fat pads in Buffalo rats. therapeutic application,unassigned 1,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15375506&form=6&db=m Expression of poly(ADP-ribose) polymerase in human hepatocellular carcinoma and analysis of biopsy specimens obtained under sonographic guidance. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17663173&form=6&db=m [Role of proteins in Fas-mediated apoptosis in tumor cells and lymphocytes co-cultured in vitro] ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18424914&form=6&db=m Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18695907&form=6&db=m PJ34, an inhibitor of PARP-1, suppresses cell growth and enhances the suppressive effects of cisplatin in liver cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19168119&form=6&db=m Chemopreventive action of Lygodium flexuosum extract in human hepatoma PLC/PRF/5 and Hep 3B cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20335389&form=6&db=m EP1 Prostanoid Receptor Coupling to Gi/o Upregulates the Expression of Hypoxia-Inducible Factor-1{alpha} Through Activation of a Phosphoinositide-3 Kinase Signaling Pathway. ongoing research,unassigned 3,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21276153&form=6&db=m No associations of polymorphisms in ADPRT with hepatitis B virus clearance and hepatocellular carcinoma occurrence in a Korean population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21469509&form=6&db=m 6,(5H)-phenanthridinone protects against carbon tetrachloride-induced cytotoxicity in human HepG2 cells. ongoing research,unassigned 4,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21512226&form=6&db=m Macrophage mediated anti-proliferation effects of Anthodia camphorata non-polysaccharide based extracts on human hepatoma cells. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22542821&form=6&db=m Enhancement of cell permeabilization apoptosis-inducing activity of selenium nanoparticles by ATP surface decoration. ongoing research,unassigned 3,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22583868&form=6&db=m Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22900098&form=6&db=m Pertussis Toxin, an Inhibitor of G(?i) PCR, Inhibits Bile Acid- and Cytokine-Induced Apoptosis in Primary Rat Hepatocytes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23022185&form=6&db=m MK5 is degraded in response to doxorubicin and negatively regulates doxorubicin-induced apoptosis in hepatocellular carcinoma cells. unassigned - 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23275542&form=6&db=m 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. causal interaction,unassigned 1,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23417763&form=6&db=m Momordin Ic induces HepG2 cell apoptosis through MAPK and PI3K/Akt-mediated mitochondrial pathways. causal interaction,unassigned 1,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23953496&form=6&db=m Update on hepatocellular carcinoma breakthroughs: Poly(ADP-ribose) polymerase inhibitors as a promising therapeutic strategy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24367566&form=6&db=m Identification of poly(ADP-ribose) polymerase-1 as a cell cycle regulator through modulating Sp1 mediated transcription in human hepatoma cells. causal interaction,ongoing research,unassigned 3,3,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25066396&form=6&db=m Inhibited effects of veliparib combined doxorubicin for BEL-7404 proliferation of human liver cancer cell line. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25072752&form=6&db=m Poly (ADP-ribose) polymerase inhibition synergizes with the NF-?B inhibitor DHMEQ to kill hepatocellular carcinoma cells. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25139788&form=6&db=m PARP inhibition and the radiosensitizing effects of the PARP inhibitor ABT-888 in in vitro hepatocellular carcinoma models. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25499136&form=6&db=m PARP-1 inhibitor sensitizes arsenic trioxide in hepatocellular carcinoma cells via abrogation of G2/M checkpoint and suppression of DNA damage repair. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25810958&form=6&db=m The assessment of an in-vitro model for evaluating the role of PARP in ethanol-mediated hepatotoxicity. ongoing research,unassigned 4,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26258887&form=6&db=m PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26883192&form=6&db=m Global proteomic profiling in multistep hepatocarcinogenesis and identification of PARP1 as a novel molecular marker in hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27041572&form=6&db=m Interaction of hepatitis B virus X protein with PARP1 results in inhibition of DNA repair in hepatocellular carcinoma. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27416811&form=6&db=m Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway. unassigned - 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27484730&form=6&db=m Arsenite-loaded nanoparticles inhibit PARP-1 to overcome multidrug resistance in hepatocellular carcinoma cells. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28487110&form=6&db=m NF90 regulates PARP1 mRNA stability in hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28498459&form=6&db=m Inhibitors of PARP-1 exert inhibitory effects on the biological characteristics of hepatocellular carcinoma cells in vitro. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28714367&form=6&db=m PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29117515&form=6&db=m Metformin and epothilone A treatment up regulate pro-apoptotic PARP-1, Casp-3 and H2AX genes and decrease of AKT kinase level to control cell death of human hepatocellular carcinoma and ovary adenocarcinoma cells. therapeutic application,unassigned 1,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29179487&form=6&db=m PARP-1 promotes tumor recurrence after warm ischemic liver graft transplantation via neutrophil recruitment and polarization. unassigned - 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29515234&form=6&db=m PARP10 suppresses tumor metastasis through regulation of Aurora A activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29776974&form=6&db=m The long noncoding RNA lncPARP1 contributes to progression of hepatocellular carcinoma through up-regulation of PARP1. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30165350&form=6&db=m Inhibition of Poly(ADP-Ribose) Polymerase Increased Lipid Accumulation Through SREBP1 Modulation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30247868&form=6&db=m Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14). causal interaction,unassigned 3,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30258223&form=6&db=m Isolation of 4,4'-bond secalonic acid D from the marine-derived fungus Penicillium oxalicum with inhibitory property against hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30400960&form=6&db=m MicroRNA-31-5p regulates chemosensitivity by preventing the nuclear location of PARP1 in hepatocellular carcinoma. therapeutic application,unassigned 1,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30573522&form=6&db=m EGFR and c-MET Cooperate to Enhance Resistance to PARP Inhibitors in Hepatocellular Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30907226&form=6&db=m Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity. unassigned - 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30936015&form=6&db=m Human alcohol dehydrogenase 1 is an acceptor protein for polyADP-ribosylation. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30940159&form=6&db=m Retraction Note: MicroRNA-31-5p regulates chemosensitivity by preventing the nuclear location of PARP1 in hepatocellular carcinoma. therapeutic application,unassigned 1,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30964366&form=6&db=m Autophagy suppresses radiation damage by activating PARP-1 and attenuating reactive oxygen species in hepatoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31175354&form=6&db=m Targeting PARP and autophagy evoked synergistic lethality in hepatocellular carcinoma. unassigned - 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31913745&form=6&db=m SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. ongoing research,unassigned 2,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32060423&form=6&db=m PLK1/NF-?B feedforward circuit antagonizes the mono-ADP-ribosyltransferase activity of PARP10 and facilitates HCC progression. causal interaction,unassigned 4,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32483468&form=6&db=m Hepatoma cell-intrinsic TLR9 activation induces immune escape through PD-L1 upregulation in hepatocellular carcinoma. causal interaction,unassigned 2,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33020270&form=6&db=m Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors. therapeutic application,unassigned 4,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33183998&form=6&db=m PARP inhibitors and radiation potentiate liver cell death in vitro. Do hepatocellular carcinomas have an achilles' heel? causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33485358&form=6&db=m PARP inhibitor Olaparib overcomes Sorafenib resistance through reshaping the pluripotent transcriptome in hepatocellular carcinoma. therapeutic application,unassigned 3,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33940508&form=6&db=m Pinus kesiya Royle ex Gordon induces apoptotic cell death in hepatocellular carcinoma HepG2 cell via intrinsic pathway by PARP and Topoisomerase I suppression. ongoing research,unassigned 1,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34221874&form=6&db=m New guaiane-type sesquiterpenoid dimers from Artemisia atrovirens and their antihepatoma activity. ongoing research,unassigned 3,0 2.4.2.30 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21908496&form=6&db=m Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30297533&form=6&db=m Targeting PARP1 in XRCC1 deficient sporadic invasive breast cancer or pre-invasive ductal carcinoma in situ induces synthetic lethality and chemoprevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.4.2.30 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30786684&form=6&db=m BRCA1 and PARP1 mRNA expression during progression from normal breast to ductal carcinoma in situ and invasive breast cancer: a laser microdissection study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.4.2.30 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30209066&form=6&db=m The TLR7/8/9 antagonist IMO-8503 inhibits cancer-induced cachexia. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Carcinoma, Merkel Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29570891&form=6&db=m Poly ADP-ribose polymerase-1 as a potential therapeutic target in Merkel cell carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Carcinoma, Neuroendocrine http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31649992&form=6&db=m Treatment of neuroendocrine carcinoma of the cervix with a PARP inhibitor based on next generation sequencing. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Carcinoma, Neuroendocrine http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32727929&form=6&db=m Evaluation of PARP and PDL-1 as potential therapeutic targets for women with high-grade neuroendocrine carcinomas of the cervix. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11162590&form=6&db=m Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12700281&form=6&db=m Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20878124&form=6&db=m Replication-dependent ?-H2AX formation is involved in docetaxel-induced apoptosis in NSCLC A549 cells. unassigned - 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21420246&form=6&db=m Functional Polymorphisms of Base Excision Repair Genes XRCC1 and APEX1 Predict Risk of Radiation Pneumonitis in Patients with Non-Small Cell Lung Cancer Treated with Definitive Radiation Therapy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21706479&form=6&db=m PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21825006&form=6&db=m Inhibition of poly(ADP-ribose) polymerase-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23275151&form=6&db=m PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23428903&form=6&db=m Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23451039&form=6&db=m New Approaches of PARP-1 Inhibitors in Human Lung Cancer Cells and Cancer Stem-Like Cells by Some Selected Anthraquinone-Derived Small Molecules. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24528514&form=6&db=m Poly (ADP-ribose) polymerase 3 (PARP3), a potential repressor of telomerase activity. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24761869&form=6&db=m Expression of ERCC1, MSH2 and PARP1 in non-small cell lung cancer and prognostic value in patients treated with platinum-based chemotherapy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24796672&form=6&db=m ?-Hydroxyundec-9-enoic acid induces apoptosis through ROS-mediated endoplasmic reticulum stress in non-small cell lung cancer cells. therapeutic application,unassigned 2,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24895135&form=6&db=m Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression. therapeutic application,unassigned 3,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24897387&form=6&db=m PARP inhibitor activates the intrinsic pathway of apoptosis in primary lung cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25145669&form=6&db=m Synergy between the NAMPT inhibitor GMX1777(8) and pemetrexed in non-small cell lung cancer cells is mediated by PARP activation and enhanced NAD consumption. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26293798&form=6&db=m Tankyrase 2 (TNKS2) polymorphism associated with risk in developing non-small cell lung cancer in a Chinese population. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26387143&form=6&db=m Negative prognostic value of high levels of intracellular poly(ADP-ribose) in non-small cell lung cancer. causal interaction,unassigned 1,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26617760&form=6&db=m Tankyrase 1 polymorphism associated with an increased risk in developing non-small cell lung cancer in a Chinese population: a proof-of-principle study. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26975633&form=6&db=m APR-246 (PRIMA-1(MET)) strongly synergizes with AZD2281 (olaparib) induced PARP inhibition to induce apoptosis in non-small cell lung cancer cell lines. unassigned - 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27020103&form=6&db=m Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality. therapeutic application,unassigned 4,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27446448&form=6&db=m Pelargonium quercetorum Agnew induces apoptosis without PARP or cytokeratin 18 cleavage in non-small cell lung cancer cell lines. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27628049&form=6&db=m Synergistic effect of fenretinide and curcumin for treatment of non-small cell lung cancer. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28460475&form=6&db=m Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signaling. unassigned - 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28461256&form=6&db=m Smoking History Predicts Sensitivity to PARP Inhibitor Veliparib in Patients with Advanced Non-Small Cell Lung Cancer. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28748826&form=6&db=m Smoking History Predicts Sensitivity to PARP Inhibitor Veliparib in Patients with Advanced Non-Small Cell Lung Cancer: Methodological Issues. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28843522&form=6&db=m WITHDRAWN: An analysis of the gene interaction networks identifying the role of PARP1 in metastasis of non-small cell lung cancer. ongoing research,unassigned 1,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29152062&form=6&db=m Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29152079&form=6&db=m An analysis of the gene interaction networks identifying the role of PARP1 in metastasis of non-small cell lung cancer. ongoing research,unassigned 2,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30127774&form=6&db=m PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30145925&form=6&db=m Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. ongoing research,unassigned 1,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30466996&form=6&db=m Identification of amentoflavone as a potent highly selective PARP-1 inhibitor and its potentiation on carboplatin in human non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30589644&form=6&db=m PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31438892&form=6&db=m Reduction of metastatic potential by inhibiting EGFR/Akt/p38/ERK signaling pathway and epithelial-mesenchymal transition after carbon ion exposure is potentiated by PARP-1 inhibition in non-small-cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31753490&form=6&db=m Non-small cell lung cancer cells with deficiencies in homologous recombination genes are sensitive to PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31786739&form=6&db=m Fluzoparib increases radiation sensitivity of non-small cell lung cancer (NSCLC) cells without BRCA1/2 mutation, a novel PARP1 inhibitor undergoing clinical trials. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31795418&form=6&db=m A Small Compound KJ-28d Enhances the Sensitivity of Non-Small Cell Lung Cancer to Radio- and Chemotherapy. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32814472&form=6&db=m Inhibition of ELF3 confers synthetic lethality of PARP inhibitor in non-small cell lung cancer. therapeutic application,unassigned 3,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33262140&form=6&db=m Phase I and Pharmacologic Study of Olaparib in Combination with High-dose Radiotherapy with and without Concurrent Cisplatin for Non-Small Cell Lung Cancer. therapeutic application,unassigned 4,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33417952&form=6&db=m PARP-1 induces EMT in non-small cell lung carcinoma cells via modulating the transcription factors Smad4, p65 and ZEB1. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33691794&form=6&db=m Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33774805&form=6&db=m PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34050966&form=6&db=m Radiosynthesis of 3 H- and 14 C-labeled Veliparib. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34132814&form=6&db=m Association of T2285C polymorphism in PARP1 gene coding region with its expression, activity and NSCLC risk along with prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.4.2.30 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34478166&form=6&db=m JASPER: Phase 2 trial of first-line niraparib plus pembrolizumab in patients with advanced non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19368128&form=6&db=m Adenovirus-mediated thymidine kinase gene therapy induces apoptosis in human epithelial ovarian cancer cells and damages PARP-1. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19699512&form=6&db=m BMS-536924 sensitizes human epithelial ovarian cancer cells to the PARP inhibitor, 3-aminobenzamide. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20049345&form=6&db=m The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21244617&form=6&db=m PARP inhibitors and epithelial ovarian cancer: an approach to targeted chemotherapy and personalised medicine. therapeutic application,unassigned 4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21293287&form=6&db=m Expression of poly (adenosine diphosphate-ribose) polymerase and p53 in epithelial ovarian cancer and their role in prognosis and disease outcome. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22489345&form=6&db=m PARP inhibition in epithelial ovarian cancer: high hopes undergo a reality check. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22489347&form=6&db=m The circuitous path of PARP inhibitor development in epithelial ovarian cancer. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22759740&form=6&db=m Poly (ADP-ribose) polymerase inhibitors: on the horizon of tailored and personalized therapies for epithelial ovarian cancer. therapeutic application,unassigned 3,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23066035&form=6&db=m Clinicopathological features of homologous recombination-deficient epithelial ovarian cancers: sensitivity to PARP inhibitors, platinum, and survival. diagnostic usage,unassigned 1,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24413181&form=6&db=m Triapine Disrupts CtIP-Mediated Homologous Recombination Repair and Sensitizes Ovarian Cancer Cells to PARP and Topoisomerase Inhibitors. therapeutic application,unassigned 3,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25132025&form=6&db=m [Maintenance therapy in patients with advanced epithelial ovarian cancer-impact of anti-angiogenic molecular targeted agents in progress]. therapeutic application,unassigned 4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25634215&form=6&db=m A Unique Subset of Epithelial Ovarian Cancers with Platinum Sensitivity and PARP Inhibitor Resistance. therapeutic application,unassigned 4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25779564&form=6&db=m Poly (ADP-ribose) polymerase inhibitors: recent advances and future development. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25991068&form=6&db=m Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27127105&form=6&db=m PARP Inhibitors in Epithelial Ovarian Cancer: State of Art and Perspectives of Clinical Research. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27155850&form=6&db=m Assessment of PARP protein expression in epithelial ovarian cancer by ELISA pharmacodynamic assay and immunohistochemistry. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27362900&form=6&db=m The Prognostic Value of BRCA1 and PARP Expression in Epithelial Ovarian Carcinoma: Immunohistochemical Detection. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27374179&form=6&db=m Cumulative defects in DNA repair pathways drive the PARP inhibitor response in high-grade serous epithelial ovarian cancer cell lines. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27779244&form=6&db=m Predictive value of ATP7b, BRCA1, BRCA2, PARP1, UIMC1 (RAP80), HOXA9, DAXX, TXN (TRX1), THBS1 (TSP1) and PRR13 (TXR1) genes in patients with epithelial ovarian cancer who received platinum-taxane first-line therapy. diagnostic usage,unassigned 1,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28101214&form=6&db=m PARP-1 may be involved in angiogenesis in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28477743&form=6&db=m PARP inhibitors alone and in combination with other biological agents in homologous recombination deficient epithelial ovarian cancer: From the basic research to the clinic. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28588062&form=6&db=m Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28823141&form=6&db=m Targeted therapy of ovarian cancer including immune check point inhibitor. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28881617&form=6&db=m Germline whole exome sequencing and large-scale replication identifies FANCM as a likely high grade serous ovarian cancer susceptibility gene. diagnostic usage,unassigned 3,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29037805&form=6&db=m Tolerance and toxicity of the PARP inhibitor olaparib in older women with epithelial ovarian cancer. therapeutic application,unassigned 3,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29205122&form=6&db=m PARP inhibitors in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29232464&form=6&db=m Treatment of recurrent ovarian cancer. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29262321&form=6&db=m BET Bromodomain Inhibition Synergizes with PARP Inhibitor in Epithelial Ovarian Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29313444&form=6&db=m Poly (ADP-ribose) polymerase inhibitors in the management of ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29774075&form=6&db=m Plectin-targeted liposomes enhance the therapeutic efficacy of a PARP inhibitor in the treatment of ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30444904&form=6&db=m Combination of triapine, olaparib, and cediranib suppresses progression of BRCA-wild type and PARP inhibitor-resistant epithelial ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30451713&form=6&db=m Update in the use and evaluation of poly (ADP-ribose) polymerase inhibitors in epithelial ovarian cancer: current and pending clinical research. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30535808&form=6&db=m Using PARP Inhibitors in the Treatment of Patients With Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30661659&form=6&db=m Targeting homologous repair deficiency in breast and ovarian cancers: Biological pathways, preclinical and clinical data. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30880072&form=6&db=m Olaparib and ?-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30967398&form=6&db=m N6-Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance. therapeutic application,unassigned 4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31037967&form=6&db=m Olaparib maintenance for first-line treatment of ovarian cancer: will SOLO1 reset the standard of care? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31076742&form=6&db=m Universal tumor DNA BRCA1/2 testing of ovarian cancer: prescreening PARPi treatment and genetic predisposition. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31375879&form=6&db=m A phase I study of the PARP inhibitor niraparib in combination with bevacizumab in platinum-sensitive epithelial ovarian cancer: NSGO AVANOVA1/ENGOT-OV24. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31534014&form=6&db=m ALDH1A1 contributes to PARP inhibitor resistance via enhancing DNA repair in BRCA2-/- ovarian cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31553293&form=6&db=m Advances in the Treatment of Ovarian Cancer Using PARP Inhibitors and the Underlying Mechanism of Resistance. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31653094&form=6&db=m Tumor BRCA Test for Patients with Epithelial Ovarian Cancer: The Role of Molecular Pathology in the Era of PARP Inhibitor Therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31669203&form=6&db=m PARP1 blockade is synthetically lethal in XRCC1 deficient sporadic epithelial ovarian cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31865042&form=6&db=m Circulating HOXA9-methylated tumour DNA: A novel biomarker of response to poly (ADP-ribose) polymerase inhibition in BRCA-mutated epithelial ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31902551&form=6&db=m Association of expression of p53, livin, ERCC1, BRCA1 and PARP1 in epithelial ovarian cancer tissue with drug resistance and prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31952659&form=6&db=m Treatment of recurrent ovarian cancer. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31960278&form=6&db=m BRCA1 Expression by Immunohistochemistry and Prognosis in Ovarian Cancer: A Systematic Review and Meta-Analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32028808&form=6&db=m A profile on the FoundationFocus CDxBRCA tests. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32218813&form=6&db=m Pharmacological ascorbate induces 'BRCAness' and enhances the effects of Poly(ADP-Ribose) polymerase inhibitors against BRCA1/2 wild-type ovarian cancer. therapeutic application,unassigned 3,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32364757&form=6&db=m PARP Inhibitors for Ovarian Cancer: Current Indications, Future Combinations, and Novel Assets in Development to Target DNA Damage Repair. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32560564&form=6&db=m Overcoming Platinum and PARP-Inhibitor Resistance in Ovarian Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32594311&form=6&db=m The Prognostic Value of PARP Expression in High-Grade Epithelial Ovarian Cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32719741&form=6&db=m Evaluation of the Efficacy and Safety of PARP Inhibitors in Advanced-Stage Epithelial Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32831909&form=6&db=m PARP inhibitors and epithelial ovarian cancer: Molecular mechanisms, clinical development and future prospective. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32878963&form=6&db=m DUETTE: a phase II randomized, multicenter study to investigate the efficacy and tolerability of a second maintenance treatment in patients with platinum-sensitive relapsed epithelial ovarian cancer, who have previously received poly(ADP-ribose) polymerase (PARP) inhibitor maintenance treatment. therapeutic application,unassigned 4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32927276&form=6&db=m BET, SRC, and BCL2 family inhibitors are synergistic drug combinations with PARP inhibitors in ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33003546&form=6&db=m The RECAP Test Rapidly and Reliably Identifies Homologous Recombination-Deficient Ovarian Carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33038760&form=6&db=m Overcoming resistance to PARP inhibitor in epithelial ovarian cancer, are we ready? diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33147530&form=6&db=m A functional polymorphism in the poly(ADP-ribose) polymerase-1 gene is associated with platinum-based chemotherapeutic response and prognosis in epithelial ovarian cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33213473&form=6&db=m Development of a 3D functional assay and identification of biomarkers, predictive for response of high-grade serous ovarian cancer (HGSOC) patients to poly-ADP ribose polymerase inhibitors (PARPis): targeted therapy. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33332934&form=6&db=m Enhanced Efficacy of Combined Therapy with Checkpoint Kinase 1 Inhibitor and Rucaparib Via Regulation of Rad-51 Expression in BRCA Wild-Type Epithelial Ovarian Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33352723&form=6&db=m PARP Inhibition Increases the Reliance on ATR/CHK1 Checkpoint Signaling Leading to Synthetic Lethality-An Alternative Treatment Strategy for Epithelial Ovarian Cancer Cells Independent from HR Effectiveness. therapeutic application,unassigned 4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33478135&form=6&db=m The Prognostic Relevance of Poly (ADP-Ribose) Polymerase Expression in Ovarian Cancer Tissue of Wild Type and BRCA-Mutation Carrier Patients. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33724122&form=6&db=m Poly (ADP-ribose) polymerase (PARP) as target for the treatment of epithelial ovarian cancer: what to know. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33801055&form=6&db=m The Prognostic and Predictive Role of Somatic BRCA Mutations in Ovarian Cancer: Results from a Multicenter Cohort Study. unassigned - 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34021367&form=6&db=m Poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors as maintenance therapy in women with newly diagnosed ovarian cancer: a systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4 2.4.2.30 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34090705&form=6&db=m Rationale for combination PARP inhibitor and antiangiogenic treatment in advanced epithelial ovarian cancer: A review. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15567158&form=6&db=m Characterization of MVP and VPARP assembly into vault ribonucleoprotein complexes. ongoing research,unassigned 4,0 2.4.2.30 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24595077&form=6&db=m Heterogeneous nuclear ribonucleoprotein U-like 1 and Poly (ADP-ribose) polymerase 1 are downregulated in renal cell carcinoma and connected with the prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 2.4.2.30 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28796254&form=6&db=m Sunitinib induces genomic instability of renal carcinoma cells through affecting the interaction of LC3-II and PARP-1. therapeutic application,unassigned 1,0 2.4.2.30 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33741027&form=6&db=m Low expression of TRAF3IP2-AS1 promotes progression of NONO-TFE3 translocation renal cell carcinoma by stimulating N6-methyladenosine of PARP1 mRNA and downregulating PTEN. diagnostic usage,unassigned 1,0 2.4.2.30 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34073906&form=6&db=m The DEAD/DEAH Box Helicase, DDX11, Is Essential for the Survival of Advanced Clear Cell Renal Cell Carcinoma and Is a Determinant of PARP Inhibitor Sensitivity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 2.4.2.30 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34307148&form=6&db=m The Emerging Role of Poly (ADP-Ribose) Polymerase Inhibitors as Effective Therapeutic Agents in Renal Cell Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34521439&form=6&db=m Correction to: Low expression of TRAF3IP2-AS1 promotes progression of NONO-TFE3 translocation renal cell carcinoma by stimulating N6-methyladenosine of PARP1 mRNA and downregulating PTEN. diagnostic usage,unassigned 1,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1649188&form=6&db=m The epidermal growth factor receptor is coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rat hepatocytes. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16338061&form=6&db=m Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16621886&form=6&db=m Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP. ongoing research,unassigned 2,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17614107&form=6&db=m Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21644054&form=6&db=m PARP1 and CASP3 gene expression in a patient with multiple head and neck squamous cell carcinoma and Parkinson disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21692479&form=6&db=m Discovery and Structure-Activity Relationships of Modified Salicylanilides as Cell Permeable Inhibitors of Poly(ADP-ribose) Glycohydrolase (PARG). causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22269178&form=6&db=m Cisplatin benefit is predicted by immunohistochemical analysis of DNA repair proteins in squamous cell carcinoma but not adenocarcinoma: theranostic modeling by NSCLC constituent histological subclasses. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22454210&form=6&db=m Expression of BAG-1 and PARP-1 in Precursor Lesions and Invasive Cervical Cancer Associated with Human Papillomavirus (HPV). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22624032&form=6&db=m PARP-1 Val762Ala polymorphism is associated with risk of cervical carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25324139&form=6&db=m Dual disruption of DNA repair and telomere maintenance for the treatment of head and neck cancer. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25667043&form=6&db=m Effect of poly(ADP-ribose)polymerase and DNA topoisomerase I inhibitors on the p53/p63-dependent survival of carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25708226&form=6&db=m PARP inhibitors: A new era of targeted therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27473117&form=6&db=m Sam68 reduces cisplatin-induced apoptosis in tongue carcinoma. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29771043&form=6&db=m [The effect of tanshinone ?A potentiates the effects of Cisplatin in Fadu cells in vitro through downregulation of survivin]. therapeutic application,unassigned 1,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31490091&form=6&db=m Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32093123&form=6&db=m Synergistic Anti-Tumour Effect of Syk Inhibitor and Olaparib in Squamous Cell Carcinoma: Roles of Syk in EGFR Signalling and PARP1 Activation. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32139402&form=6&db=m PARP inhibition enhances radiotherapy of SMAD4 deficient human head and neck squamous cell carcinomas in experimental models. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32936912&form=6&db=m Combined EGFR1 and PARP1 Inhibition Enhances the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Models. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33133138&form=6&db=m Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth. therapeutic application,unassigned 4,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33513474&form=6&db=m A phase I trial adding poly(ADP-ribose) polymerase inhibitor veliparib to induction carboplatin-paclitaxel in patients with head and neck squamous cell carcinoma: Alliance A091101. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12111185&form=6&db=m Influence of pertussis toxin on superficial bladder carcinoma in rats. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15117815&form=6&db=m Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17617028&form=6&db=m Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8575009&form=6&db=m Myocardial Gi alpha-protein levels in patients with hypertensive cardiac hypertrophy, ischemic heart disease and cardiogenic shock. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11324523&form=6&db=m [The role of G protein, protein kinase C and Na(+)-H+ exchanger in endothelin-1-induced cardiomyocyte hypertrophic responses] causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12011985&form=6&db=m Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15374823&form=6&db=m Increased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16632544&form=6&db=m Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16716347&form=6&db=m PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17235412&form=6&db=m Possible role of poly(ADP-ribose) polymerase in pathological and physiological cardiac hypertrophy. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18657544&form=6&db=m PARP mediates structural alterations in diabetic cardiomyopathy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18806606&form=6&db=m Effect of L-2286, a poly(ADP-ribose)polymerase inhibitor and enalapril on myocardial remodeling and heart failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20434371&form=6&db=m Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20643208&form=6&db=m Multifarious molecular signaling cascades of cardiac hypertrophy: can the muddy waters be cleared? causal interaction,unassigned 1,0 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23261455&form=6&db=m PARP-2 knockdown protects cardiomyocytes from hypertrophy via activation of SIRT1. causal interaction,unassigned 4,0 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24462865&form=6&db=m Salvianolic acid B protects cardiomyocytes from angiotensin II-induced hypertrophy via inhibition of PARP-1. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24859603&form=6&db=m AG-690/11026014, a novel PARP-1 inhibitor, protects cardiomyocytes from AngII-induced hypertrophy. causal interaction,unassigned 4,0 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25625556&form=6&db=m The orphan receptor NOR1 participates in isoproterenol-induced cardiac hypertrophy by regulating PARP-1. unassigned - 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27686254&form=6&db=m The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1 participates in isoproterenol-induced cardiac hypertrophy. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28784648&form=6&db=m Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure. unassigned - 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29501586&form=6&db=m PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30030529&form=6&db=m PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32139662&form=6&db=m SIRT3 inhibits cardiac hypertrophy by regulating PARP-1 activity. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33020597&form=6&db=m The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Parp10 mRNA. unassigned - 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33110392&form=6&db=m E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34094834&form=6&db=m The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy. unassigned - 2.4.2.30 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1497577&form=6&db=m Quantification of Gi alpha-proteins in the failing and nonfailing human myocardium. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.4.2.30 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10949908&form=6&db=m Myocardial postischemic injury is reduced by polyADPripose polymerase-1 gene disruption. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911332&form=6&db=m Cardioprotective effects of poly(ADP-ribose) polymerase inhibition. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911334&form=6&db=m Roles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15962096&form=6&db=m The pathogenesis of diabetic complications: the role of DNA injury and poly(ADP-ribose) polymerase activation in peroxynitrite-mediated cytotoxicity. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17919258&form=6&db=m Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21697725&form=6&db=m Regulation of kinase cascade activation and heat shock protein expression by poly(ADP-ribose) polymerase inhibition in doxorubicin-induced heart failure. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26691239&form=6&db=m Disruption of Nrf2 Synergizes with High Glucose to Cause Heightened Myocardial Oxidative Stress and Severe Cardiomyopathy in Diabetic Mice. causal interaction,unassigned 3,0 2.4.2.30 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29229534&form=6&db=m A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways. therapeutic application,unassigned 1,0 2.4.2.30 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30359575&form=6&db=m PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1? axis. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33172999&form=6&db=m Trypanosoma cruzi Induces the PARP1/AP-1 Pathway for Upregulation of Metalloproteinases and Transforming Growth Factor ? in Macrophages: Role in Cardiac Fibroblast Differentiation and Fibrosis in Chagas Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3 2.4.2.30 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34410682&form=6&db=m CircTLK1 modulates sepsis-induced cardiomyocyte apoptosis via enhancing PARP1/HMGB1 axis-mediated mitochondrial DNA damage by sponging miR-17-5p. ongoing research,unassigned 2,0 2.4.2.30 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1497577&form=6&db=m Quantification of Gi alpha-proteins in the failing and nonfailing human myocardium. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.4.2.30 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1942080&form=6&db=m Immunodetectable levels of the inhibitory guanine nucleotide-binding regulatory proteins in failing human heart: discordance with measurements of adenylate cyclase activity and levels of pertussis toxin substrate. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2169357&form=6&db=m Increase of Gi alpha in human hearts with dilated but not ischemic cardiomyopathy. unassigned - 2.4.2.30 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2511034&form=6&db=m Coupling of adenosine receptors to a pertussis toxin-sensitive G protein in the human heart. causal interaction,unassigned 1,0 2.4.2.30 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20434371&form=6&db=m Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11861791&form=6&db=m Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21926192&form=6&db=m The clinically active PARP inhibitor AG014699 ameliorates cardiotoxicity but does not enhance the efficacy of doxorubicin, despite improving tumor perfusion and radiation response in mice. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29913208&form=6&db=m Influence of PARP-1 inhibition in the cardiotoxicity of the topoisomerase 2 inhibitors doxorubicin and mitoxantrone. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30368987&form=6&db=m Hesperidin promotes lysosomal biogenesis in chronically ethanol-induced cardiotoxicity in rats: A proposed mechanisms of protection. causal interaction,unassigned 4,0 2.4.2.30 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30377735&form=6&db=m sFRP1 has a biphasic effect on doxorubicin-induced cardiotoxicity in a cellular location-dependent manner in NRCMs and Rats. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33110392&form=6&db=m E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15219813&form=6&db=m Restoration of the endothelial function in the aortic rings of apolipoprotein E deficient mice by pharmacological inhibition of the nuclear enzyme poly(ADP-ribose) polymerase. causal interaction,unassigned 3,0 2.4.2.30 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15306224&form=6&db=m Mitochondrial-to-nuclear translocation of apoptosis-inducing factor in cardiac myocytes during oxidant stress: potential role of poly(ADP-ribose) polymerase-1. unassigned - 2.4.2.30 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15523000&form=6&db=m Poly(ADP-Ribose) polymerase promotes cardiac remodeling, contractile failure, and translocation of apoptosis-inducing factor in a murine experimental model of aortic banding and heart failure. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026326&form=6&db=m Pharmacological inhibition of poly(ADP-ribose) polymerase in cardiovascular disorders: future directions. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16480745&form=6&db=m In vitro effect of the potent poly(ADP-ribose) polymerase (PARP) inhibitor INO-1001 alone and in combination with aspirin, eptifibatide, tirofiban, enoxaparin or alteplase on haemostatic parameters. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17055069&form=6&db=m Novel modulators of poly(ADP-ribose) polymerase. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17397824&form=6&db=m Poly(ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro. causal interaction,unassigned 4,0 2.4.2.30 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17438151&form=6&db=m Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17520094&form=6&db=m Poly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17919258&form=6&db=m Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19362586&form=6&db=m PARP inhibitors: New partners in the therapy of cancer and inflammatory diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19549508&form=6&db=m PCB-induced endothelial cell dysfunction: role of poly(ADP-ribose) polymerase. causal interaction,unassigned 3,0 2.4.2.30 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29501586&form=6&db=m PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30323296&form=6&db=m PARP1 promote autophagy in cardiomyocytes via modulating FoxO3a transcription. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31500199&form=6&db=m The Role of PARPs in Inflammation-and Metabolic-Related Diseases: Molecular Mechanisms and Beyond. causal interaction,unassigned 3,0 2.4.2.30 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33485900&form=6&db=m NAD+ and cardiovascular diseases. unassigned - 2.4.2.30 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34124031&form=6&db=m Sp1 Targeted PARP1 Inhibition Protects Cardiomyocytes From Myocardial Ischemia-Reperfusion Injury via Downregulation of Autophagy. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 caspase-3 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11350920&form=6&db=m Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death. unassigned - 2.4.2.30 Catalepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8253125&form=6&db=m Cholera toxin antagonizes morphine-induced catalepsy through a cyclic AMP-independent mechanism. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 2.4.2.30 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18506358&form=6&db=m Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19098320&form=6&db=m Poly(ADP-ribose)polymerase inhibition counteracts cataract formation and early retinal changes in streptozotocin-diabetic rats. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26990173&form=6&db=m PARP-1 inhibition influences the oxidative stress response of the human lens. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27840165&form=6&db=m Associations of PARP-1 variant rs1136410 with PARP activities, oxidative DNA damage, and the risk of age-related cataract in a Chinese Han population: A two-stage case-control analysis. diagnostic usage,unassigned 2,0 2.4.2.30 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32631099&form=6&db=m Biochemical Evidence Indicates the Preventive Effect of Resveratrol and Nicotinamide in the Treatment of STZ-induced Diabetic Cataract. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17084037&form=6&db=m The role of poly(ADP-ribose) polymerase-1 in CNS disease. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17222947&form=6&db=m Multiple roles for poly(ADP-ribose)polymerase-1 in neurological disease. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25049175&form=6&db=m Targeting poly(ADP-ribose)polymerase1 in neurological diseases: A promising trove for new pharmacological interventions to enter clinical translation. causal interaction,unassigned 4,0 2.4.2.30 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33631119&form=6&db=m PARP-DNA trapping ability of PARP inhibitors jeopardizes astrocyte viability: Implications for CNS disease therapeutics. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Central Nervous System Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19533660&form=6&db=m PARP1 expression in pediatric central nervous system tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 2.4.2.30 Cerebellar Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28002403&form=6&db=m XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.2.30 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19066076&form=6&db=m Poly(ADP-ribose) polymerase activation and brain edema formation by hemoglobin after intracerebral hemorrhage in rats. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10657571&form=6&db=m Evaluation of the poly(ADP-ribose) polymerase gene in human stroke. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16202986&form=6&db=m Neuroprotective effects of KCL-440, a new poly(ADP-ribose) polymerase inhibitor, in the rat middle cerebral artery occlusion model. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21741620&form=6&db=m MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor, ameliorates ischemic brain damage in a non-human primate model. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22465010&form=6&db=m Reversible induction of PARP1 degradation by p53-inducible cis-imidazoline compounds. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26220474&form=6&db=m Protection of the brain following cerebral ischemia through the attenuation of PARP-1-induced neurovascular unit damage in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 2.4.2.30 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32202712&form=6&db=m [Effect of acupuncture on neurological function, cerebral infarction volume, thrombolysis time window and cerebral cell apoptosis signaling pathway in cerebral infarction rats]. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1 2.4.2.30 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32338336&form=6&db=m Baicalein attenuates caspase-independent cells death via inhibiting PARP-1 activation and AIF nuclear translocation in cerebral ischemia/reperfusion rats. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9334719&form=6&db=m Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23816753&form=6&db=m Neuropilin-1 modulates vascular endothelial growth factor-induced poly(ADP-ribose)-polymerase leading to reduced cerebrovascular apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Cervical Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26905326&form=6&db=m Poly(ADP-Ribose) Polymerase in Cervical Cancer Pathogenesis: Mechanism and Potential Role for PARP Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Chagas Cardiomyopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8301665&form=6&db=m Evidence that myocardial pertussis toxin substrates are uniquely altered in acute murine Chagas' disease in a manner unrelated to myocardial dysfunction. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8301665&form=6&db=m Evidence that myocardial pertussis toxin substrates are uniquely altered in acute murine Chagas' disease in a manner unrelated to myocardial dysfunction. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23049934&form=6&db=m Inhibition of poly(ADP-ribose) polymerase interferes with Trypanosoma cruzi infection and proliferation of the parasite. therapeutic application,unassigned 2,0 2.4.2.30 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29851986&form=6&db=m PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance. ongoing research,unassigned 3,0 2.4.2.30 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33172999&form=6&db=m Trypanosoma cruzi Induces the PARP1/AP-1 Pathway for Upregulation of Metalloproteinases and Transforming Growth Factor ? in Macrophages: Role in Cardiac Fibroblast Differentiation and Fibrosis in Chagas Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3 2.4.2.30 Chickenpox http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28233625&form=6&db=m Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Chickenpox http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32067048&form=6&db=m Waning vaccine immunity and vaccination responses in children treated for acute lymphoblastic leukemia: A Canadian Immunization Research Network Study. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Chickenpox http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33928900&form=6&db=m Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019. diagnostic usage,unassigned 2,0 2.4.2.30 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10209503&form=6&db=m Binding of tumour necrosis factor-alpha (TNF-alpha) to TNF-RI induces caspase(s)-dependent apoptosis in human cholangiocarcinoma cell lines. unassigned - 2.4.2.30 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24239776&form=6&db=m Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma. ongoing research,unassigned 3,0 2.4.2.30 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24603802&form=6&db=m XIAP Antagonist Embelin Inhibited Proliferation of Cholangiocarcinoma Cells. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26622683&form=6&db=m Guggulsterone inhibits human cholangiocarcinoma Sk-ChA-1 and Mz-ChA-1 cell growth by inducing caspase-dependent apoptosis and downregulation of survivin and Bcl-2 expression. unassigned - 2.4.2.30 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29479816&form=6&db=m PARP inhibitor olaparib sensitizes cholangiocarcinoma cells to radiation. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31605774&form=6&db=m The combination of BET and PARP inhibitors is synergistic in models of cholangiocarcinoma. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32494639&form=6&db=m Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33330039&form=6&db=m Case Report: BAP1 Mutation and RAD21 Amplification as Predictive Biomarkers to PARP Inhibitor in Metastatic Intrahepatic Cholangiocarcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1279450&form=6&db=m Peptidergic modulation of G-protein coupled cyclic-AMP accumulation in the rat caudate nucleus. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1279515&form=6&db=m Chloride channels in cultured human skeletal muscle are regulated by G proteins. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1280320&form=6&db=m Identification of G-proteins in rat parotid gland plasma membranes and granule membranes: presence of distinct components in granule membranes. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1310601&form=6&db=m A comparative study of endothelin- and platelet-activating-factor-mediated signal transduction and prostaglandin synthesis in rat Kupffer cells. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311240&form=6&db=m Isolation and mode of action of rabbit corticostatic (antiadrenocorticotropin) peptides. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311686&form=6&db=m Effects of Ro 5-4864 and PK 11195 in rat duodenum and vas deferens. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1315680&form=6&db=m Cyclic guanosine monophosphate analogs do not reverse bacterial toxin modulation of lactogen-stimulated NB2 cell mitogenesis. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1315788&form=6&db=m Ligand-induced formation of the leukotriene B4 receptor-G protein complex of human polymorphonuclear leukocytes. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1317174&form=6&db=m Biosynthesis of paf-acether in cultured-mouse mast cells: the role of calcium and G proteins. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1319465&form=6&db=m In vivo evidence that lithium inactivates Gi modulation of adenylate cyclase in brain. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1320658&form=6&db=m Modulation of meiotic arrest in mouse oocytes by guanyl nucleotides and modifiers of G-proteins. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322406&form=6&db=m Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322665&form=6&db=m Effects of cyclosporine A on cyclic AMP generation and GTP-binding proteins in isolated islets. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322969&form=6&db=m Evidence for the implication of phosphoinositol signal transduction in mu-opioid inhibition of DNA synthesis. causal interaction,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1323474&form=6&db=m Differentiation of renal Na(+)-K(+)-ATPase in control and streptozotocin-induced diabetic mice by G-protein acting toxins and phorbol esters. ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1333052&form=6&db=m Thyrotropin-releasing hormone and gonadotropin-releasing hormone receptors activate phospholipase C by coupling to the guanosine triphosphate-binding proteins Gq and G11. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1334091&form=6&db=m Purification of a histamine H3 receptor negatively coupled to phosphoinositide turnover in the human gastric cell line HGT1. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1335333&form=6&db=m Characterization of adenosine receptors in brush-border membranes from pig kidney. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1354343&form=6&db=m Pertussis toxin pretreatment abolishes the inhibitory effect of riluzole and carbachol on D-[3H]aspartate release from cultured cerebellar granule cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1361912&form=6&db=m Idazoxan down-regulates beta-adrenoceptors on C6 glioma cells in vitro. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1370436&form=6&db=m Biphasic effect of cAMP-elevating agents on ICAM-1 expression stimulated by retinoic acid and interferon gamma. diagnostic usage,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1373177&form=6&db=m Properties of muscarinic-stimulated adenylate cyclase activity in rat olfactory bulb. therapeutic application,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1378444&form=6&db=m Cloning and characterization of a cDNA coding for the alpha-subunit of a stimulatory G protein from Schistosoma mansoni. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1379345&form=6&db=m Antisense oligodeoxynucleotides to GS protein alpha-subunit sequence accelerate differentiation of fibroblasts to adipocytes. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1380512&form=6&db=m Role of protein kinase C in transforming growth factor-beta 1 induction of carcinoembryonic antigen in human colon carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1425441&form=6&db=m Carbohydrate moiety of follitropin receptor is not required for high affinity hormone-binding or for functional coupling between receptor and guanine nucleotide-binding protein in bovine calf testis membranes. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1425983&form=6&db=m Effects of angiotensin II and angiotensin III on airway epithelial short-circuit current: involvement of pertussis toxin-sensitive G protein. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1426932&form=6&db=m Alterations of G protein function in cardiac tissues from streptozotocin-induced chronic diabetic rats. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1429559&form=6&db=m The lymphoma transmembrane glycoprotein GP85 (CD44) is a novel guanine nucleotide-binding protein which regulates GP85 (CD44)-ankyrin interaction. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1445283&form=6&db=m Enhanced expression of inhibitory guanine nucleotide regulatory protein in spontaneously hypertensive rats. Relationship to adenylate cyclase inhibition. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1454136&form=6&db=m Genes coding for proteins in central nervous system myelin. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1464309&form=6&db=m Multiple trimeric G-proteins on the trans-Golgi network exert stimulatory and inhibitory effects on secretory vesicle formation. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1480165&form=6&db=m Post-receptor defect accounts for phosphorylase hypersensitivity in cultured diabetic cardiomyocytes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1491429&form=6&db=m G-protein activators induce a potassium conductance in murine macrophages. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1510880&form=6&db=m Prostaglandin E2 can bimodally inhibit and stimulate the epididymal adipocyte adenylyl cyclase activity. therapeutic application,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1512271&form=6&db=m K-ras transformation greatly increases the toxin-dependent ADP-ribosylation of GTP binding proteins in thyroid cells. Involvement of an inhibitor of the ADP-ribosylation reaction. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1517818&form=6&db=m Isoproterenol enhances a calcium-independent potassium current in mouse anterior pituitary tumor cells. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1539113&form=6&db=m Participation of pertussis toxin-sensitive GTP-binding regulatory proteins in the suppression of baroreceptor reflex by neurotensin in the rat. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1547891&form=6&db=m Probable occurrence of toxin-susceptible G proteins in the nematode Caenorhabditis elegans. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1564434&form=6&db=m Modification of the amounts of G proteins and of the activity of adenylyl cyclase in human benign thyroid tumours. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1588460&form=6&db=m Occurrence and biochemical characterization of GTP-binding proteins in Candida albicans. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1597165&form=6&db=m The effects of extracellular calcium and epinephrine on cytosolic-free calcium in single rat adipocytes. therapeutic application,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1618319&form=6&db=m GTP-binding proteins in luminal and basolateral membranes from pars convoluta and pars recta of rabbit kidney proximal tubule. diagnostic usage,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1632762&form=6&db=m Properties of 1-methyladenine receptors in starfish oocyte membranes: involvement of pertussis toxin-sensitive GTP-binding protein in the receptor-mediated signal transduction. diagnostic usage,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1635279&form=6&db=m Characterization of G-proteins in rat glomeruli. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1636682&form=6&db=m Heat shock increases cytosolic free Ca2+ concentration via Na(+)-Ca2+ exchange in human epidermoid A 431 cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1636738&form=6&db=m Hormonal regulation of rat renal proximal tubule brush-border membrane ionic permeability. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645335&form=6&db=m Identification of a botulinum C3-like enzyme in bovine brain that catalyzes ADP-ribosylation of GTP-binding proteins. diagnostic usage,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645346&form=6&db=m Cyclic AMP-dependent regulation of the number of [3H]batrachotoxinin benzoate binding sites on rat cardiac myocytes. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645524&form=6&db=m Insulin activates GTP binding to a 40 kDa protein in fat cells. ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1646032&form=6&db=m The effect of PGF2 alpha on parathyroid hormone-stimulated cyclic AMP production in mouse osteoblastic cell, MC3T3E1. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1646330&form=6&db=m Ligand binding and functional characterization of muscarinic acetylcholine receptors on the TE671/RD human cell line. causal interaction,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1651723&form=6&db=m Astrocytes possess prostaglandin F2 alpha receptors coupled to phospholipase C. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652183&form=6&db=m Localization of several G-protein subunits to the apical and basolateral membranes of cortical tubular cells from the rat kidney. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652482&form=6&db=m Stimulation of DNA synthesis in Jurkat cells by synergistic action between adenine and guanine nucleotides. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1653071&form=6&db=m Regulation of bradykinin receptor level by cholera toxin, pertussis toxin and forskolin in cultured human fibroblasts. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1654121&form=6&db=m A guanine nucleotide-binding protein mediates 1,25-dihydroxy-vitamin D-3-dependent rapid stimulation of Ca2+ uptake in skeletal muscle. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1657372&form=6&db=m Regulation of kinesin expression and type IV collagenase secretion in invasive human prostate PC-3 tumor sublines. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1659908&form=6&db=m Muscarinic receptor-linked elevation of cAMP in SH-SY5Y neuroblastoma cells is mediated by Ca2+ and protein kinase C. diagnostic usage,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1660361&form=6&db=m Involvement of a GTP-binding protein in stimulating action of angiotensin II on calcium channels in vascular smooth muscle cells. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1662135&form=6&db=m Functional modification by cholera-toxin-catalyzed ADP-ribosylation of a guanine-nucleotide-binding regulatory protein serving as the substrate of pertussis toxin. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1662511&form=6&db=m Epidermal growth factor activation of rat parotid gland adenylate cyclase and mediation by a GTP-binding regulatory protein. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1662619&form=6&db=m Activation of a keratinocyte phospholipase A2 by bradykinin and 4 beta-phorbol 12-myristate 13-acetate. Evidence for a receptor-GTP-binding protein versus a protein-kinase-C mediated mechanism. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1665289&form=6&db=m Changes in inositol 1,4,5-trisphosphate mass in agonist-stimulated human neutrophils. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1666919&form=6&db=m G-protein mediation of cannabinoid-induced phospholipase activation. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1667331&form=6&db=m Role of a pertussis toxin sensitive G-protein in mediating the effects of phorbol esters on receptor activated cyclic AMP accumulation in Jurkat cells. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1668103&form=6&db=m PAF effects on transmembrane signaling pathways in rat Kupffer cells. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1681036&form=6&db=m Dopaminergic receptors linked to adenylate cyclase in human cerebromicrovascular endothelium. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1682005&form=6&db=m Guanine nucleotide binding proteins and the regulation of cyclic AMP synthesis in NS20Y neuroblastoma cells: role of D1 dopamine and muscarinic receptors. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,3 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1683639&form=6&db=m [Isoproterenol, denopamine, and atenolol-induced alterations in beta-adrenergic receptor-adenylate cyclase system of rat myocardium] diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1693850&form=6&db=m Intracellular coupling of prostaglandin inhibition of acid secretion in isolated rabbit gastric parietal cells. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1696725&form=6&db=m Microsomal and cytosolic fractions of guinea pig hepatocytes contain 100-kilodalton GTP-binding proteins reactive with antisera against alpha subunits of stimulatory and inhibitory heterotrimeric GTP-binding proteins. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1698537&form=6&db=m Functional interactions between colony-stimulating factors and the insulin family hormones for human myeloid leukemic cells. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1703181&form=6&db=m Activation of dense human tonsilar B cells. Induction of c-myc gene expression via two distinct signal transduction pathways. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1709748&form=6&db=m Functional and molecular characterization of CCK receptors in the rat pancreatic acinar cell line AR 4-2J. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1715380&form=6&db=m Substance P stimulation of polyphosphoinositide hydrolysis in rat anterior pituitary membranes involves a GTP-dependent mechanism. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1715709&form=6&db=m Signal transduction alterations in GH(1)2C1 rat pituitary tumour cells following treatment with 5-azacytidine. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1715770&form=6&db=m Modification of biological responses to interleukin-1 by agents that perturb signal transduction pathways. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1723766&form=6&db=m G proteins subserve relaxations mediated by adenosine receptors in human coronary artery. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1730631&form=6&db=m Modification of the function of pertussis toxin substrate GTP-binding protein by cholera toxin-catalyzed ADP-ribosylation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1731175&form=6&db=m Lithium administration modulates platelet Gi in humans. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1731754&form=6&db=m Epoxyeicosatrienoic acid stimulates ADP-ribosylation of a 52 kDa protein in rat liver cytosol. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1732703&form=6&db=m Pertussis-toxin insensitive enkephalin inhibition of adenylyl cyclase in lacrimal acinar cells. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1733734&form=6&db=m The stimulatory and inhibitory effects of dopamine on prolactin secretion involve different G-proteins. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1736882&form=6&db=m Effects of litter removal on the lipolytic response and the regulatory components of the adenylate cyclase in adipocytes isolated from lactating rats. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1747218&form=6&db=m Altered expression of inhibitory guanine nucleotide regulatory proteins (Gi alpha) in spontaneously hypertensive rats. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1775589&form=6&db=m Signal transduction modulation by lithium: cell culture, cerebral microdialysis and human studies. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1778307&form=6&db=m Monoclonal antibodies against the enzymatic subunit of both pertussis and cholera toxins. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1804634&form=6&db=m G protein function in the ischaemic myocardium. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1826680&form=6&db=m Selective loss of pertussis toxin-sensitive G-proteins from the plasma membrane after antibody-induced internalization of T-cell surface molecules. ongoing research,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1829655&form=6&db=m T cell activation via the T cell receptor: a comparison between WT31 (defining alpha/beta TcR)-induced and anti-CD3-induced activation of human T lymphocytes. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1835459&form=6&db=m A novel approach to detect toxin-catalyzed ADP-ribosylation in intact cells: its use to study the action of Pasteurella multocida toxin. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848817&form=6&db=m Treatment of intact striatal neurones with cholera toxin or 8-bromoadenosine 3',5'-(cyclic)phosphate decreases the ability of pertussis toxin to ADP-ribosylate the alpha-subunits of inhibitory and other guanine-nucleotide-binding regulatory proteins, Gi and Go. Evidence for two distinct mechanisms. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848855&form=6&db=m Agonist-dependent, cholera toxin-catalyzed ADP-ribosylation of pertussis toxin-sensitive G-proteins following transfection of the human alpha 2-C10 adrenergic receptor into rat 1 fibroblasts. Evidence for the direct interaction of a single receptor with two pertussis toxin-sensitive G-proteins, Gi2 and Gi3. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1850493&form=6&db=m Cholera toxin and pertussis toxin on opioid- and alpha 2-mediated supraspinal analgesia in mice. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1861239&form=6&db=m Stimulatory effect of guanine nucleotides on prostaglandin E1 binding to murine renal outer medulla. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1874563&form=6&db=m An autocrine motility factor secreted by the Dunning R-3327 rat prostatic adenocarcinoma cell subtype AT2.1. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1899403&form=6&db=m Evidence for the involvement of a pertussis toxin-insensitive G-protein in egg activation of the frog, Xenopus laevis. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1901617&form=6&db=m Computer modelling of the NAD binding site of ADP-ribosylating toxins: active-site structure and mechanism of NAD binding. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1904910&form=6&db=m Detection of G proteins in purified bovine brain myelin. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1906389&form=6&db=m Bovine pituitary, kidney, uterine and mammary gland extracts contain bovine mammary epithelium growth factors that synergise with IGF-I and fetal calf serum: indication for involvement of GTP-binding proteins. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1908364&form=6&db=m Effects of calcium on light-activated GTP-binding proteins in squid photoreceptor membranes. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1908825&form=6&db=m Effect of site-directed mutagenic alterations on ADP-ribosyltransferase activity of the A subunit of Escherichia coli heat-labile enterotoxin. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1916613&form=6&db=m The uterotonic action of the aqueous extract of Bridelia atroviridis in the rat. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1921983&form=6&db=m GTP-binding protein G alpha Z: its down-regulation by dexamethasone and its credentials as a mediator of antigen-induced responses in RBL-2H3 cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1930168&form=6&db=m Signal transduction in Coprinus congregatus: evidence for the involvement of G proteins in blue light photomorphogenesis. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1935791&form=6&db=m The effects of endothelins on the secretion of prolactin, luteinizing hormone, and follicle-stimulating hormone are mediated by different guanine nucleotide-binding proteins. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1937784&form=6&db=m Site-specific mutagenesis of the catalytic subunit of cholera toxin: substituting lysine for arginine 7 causes loss of activity. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1944610&form=6&db=m Terminal serotonin autoreceptor function in the rat hippocampus is not modified by pertussis and cholera toxins. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1963397&form=6&db=m In vitro effects of 17 beta-oestradiol on the sensitivity of receptors coupled to adenylate cyclase on striatal neurons in primary culture. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1965516&form=6&db=m Enhancement in beta-adrenergic responsiveness of adenylate cyclase in rat liver during regeneration after carbon tetrachloride administration. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1966810&form=6&db=m Tumor necrosis factor alpha 'primes' the platelet-activating factor-induced superoxide production by human neutrophils: possible involvement of G proteins. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1967538&form=6&db=m Effects of tiazofurin on guanine nucleotide binding regulatory proteins in HL-60 cells. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1982458&form=6&db=m Somatostatin acts through G-proteins on dopaminergic adenylate cyclase in the caudate-putamen of the rat. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1990017&form=6&db=m Activation of cell membrane potassium conductance by mercury in cultured renal epithelioid (MDCK) cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2105321&form=6&db=m Gz, a guanine nucleotide-binding protein with unique biochemical properties. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2108729&form=6&db=m Two distinct light regulated G-proteins in octopus photoreceptors. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2109044&form=6&db=m Guanine nucleotide-binding protein regulation of microsomal phospholipase D activity of canine cerebral cortex. ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2109707&form=6&db=m Pertussis toxin-mediated ADP-ribosylation of rabbit luteal Gi uncouples enkephalin inhibition of adenylyl cyclase. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2114479&form=6&db=m Fluoride produces endothelium-dependent relaxation and endothelium-independent contraction in coronary artery. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2118385&form=6&db=m Altered responses to modulators of guanine nucleotide binding protein activity in endotoxin tolerance. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2118390&form=6&db=m [Identification and purification of GTP-binding regulatory proteins from plasma membranes of swine heart] unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2124115&form=6&db=m Cross-linking of G-proteins to the prolactin receptor in rat NB2 lymphoma cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2124806&form=6&db=m Light-dependent GTP-binding proteins in squid photoreceptors. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2129222&form=6&db=m Signal transduction of a tissue interaction during embryonic heart development. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2139456&form=6&db=m On the mechanism of action of dexamethasone in a rat mast cell line (RBL-2H3 cells). Evidence for altered coupling of receptors and G-proteins. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2141600&form=6&db=m Mechanism of action of GTP in the induction of Ca2+ release from hepatic microsomes. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153030&form=6&db=m Characterization of influenza A virus activation of the human neutrophil. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2154471&form=6&db=m Interleukin-1 signal transduction. Increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4). ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2155099&form=6&db=m The role of G-proteins in the mitogenesis of rat lactogen-dependent and lactogen-independent Nb2 lymphoma cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2156932&form=6&db=m Functional maturation of human T lymphocytes is accompanied by changes in the G-protein pattern. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2158431&form=6&db=m Stimulation of luteinizing hormone release by sodium fluoride is independent of protein kinase-C activity and unaffected by desensitization to gonadotropin-releasing hormone. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2160028&form=6&db=m Cholera and pertussis exotoxins protect mice against the lethal Schwartzman reaction and antagonize the effects of lipopolysaccharide on second messenger systems. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2163626&form=6&db=m Interleukin (IL)-8-induced in vitro human lymphocyte migration is inhibited by cholera and pertussis toxins and inhibitors of protein kinase C. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2164554&form=6&db=m Activation of the superoxide-generating NADPH oxidase of macrophages by sodium dodecyl sulfate in a soluble cell-free system: evidence for involvement of a G protein. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2164927&form=6&db=m Follicle-stimulating hormone receptor-mediated uptake of 45Ca2+ by cultured rat Sertoli cells does not require activation of cholera toxin- or pertussis toxin-sensitive guanine nucleotide binding proteins or adenylate cyclase. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2169284&form=6&db=m Pertussis toxin B-subunit-induced Ca2(+)-fluxes in Jurkat human lymphoma cells: the action of long-term pre-treatment with cholera and pertussis holotoxins. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2169531&form=6&db=m Effects of follicle stimulating hormone, cholera toxin, pertussis toxin and forskolin on adenosine cyclic 3',5'-monophosphate output by granulosa cells from Booroola ewes with or without the F gene. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2170406&form=6&db=m Two distinct pathways of platelet-activating factor-induced hydrolysis of phosphoinositides in primary cultures of rat Kupffer cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2170558&form=6&db=m Evidence that the action of calcitonin on rat osteoclasts is mediated by two G proteins acting via separate post-receptor pathways. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2172240&form=6&db=m A novel guanine nucleotide-binding protein coupled to the alpha 1-adrenergic receptor. II. Purification, characterization, and reconstitution. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2172343&form=6&db=m Adenylate cyclase system in fetal rat keratinizing epidermal cells (FRSK cells) and SV40-transformed human keratinocytes. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2176473&form=6&db=m G-protein-mediated regulation of the insulin-responsive glucose transporter in isolated cardiac myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2176527&form=6&db=m Mitigation of beta 1- and/or beta 2-adrenoceptor function in human heart failure. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2180488&form=6&db=m Effects of insulin on inositol phosphate production in cultured rat hepatocytes. therapeutic application,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2277349&form=6&db=m Intracellular regulation of enzyme secretion from rat osteoclasts and evidence for a functional role in bone resorption. ongoing research,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2282501&form=6&db=m Blockade of morphine analgesia by both pertussis and cholera toxins in the periaqueductal gray and locus coeruleus. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2295618&form=6&db=m Activation of phospholipase C via adenosine receptors provides synergistic signals for secretion in antigen-stimulated RBL-2H3 cells. Evidence for a novel adenosine receptor. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2323384&form=6&db=m The effect of vasoactive intestinal polypeptide (VIP) on forskolin stimulated adenylate cyclase in the caudate-putamen of the rat. ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2338946&form=6&db=m Serotonin receptor-mediated activation of adenylate cyclase in the neuroblastoma NCB.20: a novel 5-hydroxytryptamine receptor. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2357660&form=6&db=m Effects of Pasteurella haemolytica A1 culture supernatant on mechanisms controlling bovine alveolar macrophage oxygen radical production. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2374126&form=6&db=m The effects of cholera toxin, pertussis toxin, sodium fluoride and alpha-interferon on prostaglandin production by the guinea-pig endometrium. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2410236&form=6&db=m Stimulation of cyclic adenosine 3',5'-monophosphate production enhances hypothalamic luteinizing hormone-releasing hormone release without increasing prostaglandin E2 synthesis: studies in prepubertal female rats. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2446725&form=6&db=m Multiple effects of phorbol ester on secretory activity in rabbit gastric glands and parietal cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2446873&form=6&db=m Protein kinase C potentiates isoproterenol-mediated cyclic AMP production without modifying the homologous desensitization process in J774 cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2447162&form=6&db=m Cholera toxin and pertussis toxin regulate the Fc receptor-mediated phagocytic response of human neutrophils in a manner analogous to regulation by monoclonal antibody 1C2. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2454105&form=6&db=m Myelin basic protein binds GTP at a single site in the N-terminus. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2455296&form=6&db=m Identification of a region in the S1 subunit of pertussis toxin that is required for enzymatic activity and that contributes to the formation of a neutralizing antigenic determinant. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2461094&form=6&db=m G protein in stimulation of PI hydrolysis by CCK in isolated rat pancreatic acinar cells. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2461309&form=6&db=m Regulatory factors that determine growth and phenotype of normal human melanocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2464756&form=6&db=m Bone Gla protein messenger ribonucleic acid is regulated by both 1,25-dihydroxyvitamin D3 and 3',5'-cyclic adenosine monophosphate in rat osteosarcoma cells. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2468472&form=6&db=m G-proteins modulate prolactin- and interleukin-2-stimulated mitogenesis in rat Nb2 lymphoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,1 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2471737&form=6&db=m Effect of nonhydrolyzable guanosine phosphate on IgE-mediated activation of phospholipase C and histamine release from rodent mast cells. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2492037&form=6&db=m Desensitization to parathyroid hormone in renal cells from aged rats is associated with alterations in G-protein activity. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2493963&form=6&db=m G proteins in Aplysia: biochemical characterization and regional and subcellular distribution. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2494654&form=6&db=m Molecular model of the G protein alpha subunit based on the crystal structure of the HRAS protein. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2496161&form=6&db=m Subcellular distribution and membrane association of human neutrophil substrates for ADP-ribosylation by pertussis toxin and cholera toxin. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2498808&form=6&db=m Identification of the pertussis and cholera toxin substrates in normal and N-ras transformed NIH3T3 fibroblasts and an assessment of their involvement in bombesin-stimulation of inositol phospholipid metabolism. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,4 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2503397&form=6&db=m Concanavalin A stimulation of O2 consumption in electropermeabilized neutrophils via a pertussis toxin-insensitive G protein. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2509235&form=6&db=m Trypanosoma cruzi: infection of cultured human endothelial cells alters inositol phosphate synthesis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2511991&form=6&db=m Cholera and pertussis toxins amplify prostacyclin synthesis in aortic smooth muscle cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2512294&form=6&db=m Chemotactic peptide receptor-supported ADP-ribosylation of a pertussis toxin substrate GTP-binding protein by cholera toxin in neutrophil-type HL-60 cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2518286&form=6&db=m Cholinergic-induced [3H] noradrenaline release in rat brain cortical slices is mediated via a pertussis toxin sensitive GTP binding protein and involves activation of protein kinase C. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2526752&form=6&db=m CD3/T-cell receptor coupling to a pertussis and cholera toxin-insensitive G-protein. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2536032&form=6&db=m Growth factors, signaling pathways, and the regulation of proliferation and differentiation in BC3H1 muscle cells. I. A pertussis toxin-sensitive pathway is involved. ongoing research,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2536043&form=6&db=m Bacterial toxins affect early events of T lymphocyte activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,2 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537798&form=6&db=m Fluoride activation of neutrophils: similarities to formylmethionyl-leucyl-phenylalanine. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2540185&form=6&db=m Two different G-proteins mediate neuropeptide Y and bradykinin-stimulated phospholipid breakdown in cultured rat sensory neurons. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2541140&form=6&db=m Cyclic AMP can partially restore platelet-derived growth factor-stimulated prostaglandin E2 biosynthesis, and calcium mobilization in EJ-ras-transformed NIH-3T3 cells. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2541143&form=6&db=m Characterization of the membrane-associated GTPase activity: effects of chemotactic factors and toxins. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2542023&form=6&db=m Regulation of the mannose 6-phosphate/IGF II receptor expression at the cell surface by mannose 6-phosphate, insulin like growth factors and epidermal growth factor. ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2542460&form=6&db=m Ontogenesis of alpha 2-adrenoceptor coupling with GTP-binding proteins in the rat telencephalon. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2543367&form=6&db=m The effect of cholera toxin on the inhibition of vasopressin-stimulated inositol phospholipid hydrolysis is a cyclic AMP-mediated event at the level of receptor binding. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2545639&form=6&db=m Antilipolytic effects of insulin and adenylate cyclase inhibitors on isolated human fat cells. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2545733&form=6&db=m Coupling of bradykinin receptors to phospholipase C in cultured fibroblasts is mediated by a G-protein. ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2548477&form=6&db=m Evidence that activation of a common G-protein by receptors for leukotriene B4 and N-formylmethionyl-leucyl-phenylalanine in HL-60 cells occurs by different mechanisms. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2548484&form=6&db=m Influence of bacterial toxins and forskolin upon vasopressin-induced inositol phosphate accumulation in WRK 1 cells. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2551649&form=6&db=m Facilitative actions of the protein kinase-C effector system on hormonally stimulated adenosine 3',5'-monophosphate production by swine luteal cells. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2552724&form=6&db=m Effects of protein kinase C activation on cyclic AMP and testosterone production of rat Leydig cells in vitro. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2553506&form=6&db=m [Role of a guanine nucleotide regulatory protein in exocrine pancreatic secretion--effects of cholera toxin and pertussis toxin on cholecystokinin action] ongoing research,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2553586&form=6&db=m Effect of sodium fluoride on the generation of lipoxygenase products from human polymorphonuclear granulocytes, mononuclear cells and platelets--indication for the involvement of G proteins. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2553705&form=6&db=m Multiple signaling pathways of histamine H2 receptors. Identification of an H2 receptor-dependent Ca2+ mobilization pathway in human HL-60 promyelocytic leukemia cells. causal interaction,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2554695&form=6&db=m Signal transduction via the B cell antigen receptor: involvement of a G protein and regulation of signaling. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2556393&form=6&db=m Increase in Gs and cyclic AMP generation in HIT cells. Evidence that the 45-kDa alpha-subunit of Gs has greater functional activity than the 52-kDa alpha-subunit. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2556491&form=6&db=m Influence of pertussis toxin on parathyroid hormone stimulated cyclic AMP production and phosphate transport in opossum kidney cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557011&form=6&db=m Stimulation of generation of inositol phosphates by carbamoylcholine and its inhibition by phorbol esters and iodide in dog thyroid cells. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557017&form=6&db=m Cholera toxin ADP-ribosylates the receptor-coupled form of pertussis toxin-sensitive G-proteins. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557657&form=6&db=m Platelet-activating factor (PAF) stimulates phosphatidylinositol hydrolysis in human peripheral blood mononuclear leukocytes. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2567609&form=6&db=m Muscarinic receptor subclassification and G-proteins: significance for lithium action in affective disorders and for the treatment of the extrapyramidal side effects of neuroleptics. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2567705&form=6&db=m Atrial natriuretic factor effects on cyclic nucleotides in a human renal cell line. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2660922&form=6&db=m [Effect of bacterial toxins on the mitogen-induced increase of the Ca2+ concentration in the cytoplasm of rat thymocytes. The role of N proteins] ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2722137&form=6&db=m Abnormal dopamine sensitivity in some human prolactinomas. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2795430&form=6&db=m Noradrenaline release enhanced by cholera toxin and pertussis toxin in rat cerebral cortical slices. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2824610&form=6&db=m Involvement of a guanine-nucleotide-binding component in membrane IgM-stimulated phosphoinositide breakdown. causal interaction,ongoing research,unassigned 3,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2826588&form=6&db=m Inhibition and activation of interleukin 2 synthesis by direct modification of guanosine triphosphate-binding proteins. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2827999&form=6&db=m Age-related and testicular regression-induced changes in adenosine 3',5'-monophosphate responses in cultured hamster Sertoli cells. ongoing research,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2830264&form=6&db=m The bombesin receptor is coupled to a guanine nucleotide-binding protein which is insensitive to pertussis and cholera toxins. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2830276&form=6&db=m Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes. causal interaction,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2831352&form=6&db=m Cholera toxin and pertussis toxin stimulate prostaglandin E2 synthesis in a murine macrophage cell line. ongoing research,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2833416&form=6&db=m Activation of adenylate cyclase in rat fat cells promotes an increase in GTP content which controls the enzyme activity. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2833927&form=6&db=m ADP-ribosylation of membrane proteins by bacterial toxins in the presence of NAD glycohydrolase. diagnostic usage,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2834069&form=6&db=m The effects of pertussis toxin and cholera toxin on mitogen-induced interleukin-2 production: evidence for G protein involvement in signal transduction. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2834280&form=6&db=m [Abnormalities in the beta-adrenergic receptor-adenylate cyclase system in the ventricular myocardium of spontaneously hypertensive rats] ongoing research,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2834352&form=6&db=m Properties of a novel GTP-binding protein which is associated with soluble phosphoinositides-specific phospholipase C. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2834452&form=6&db=m G protein coupling of antigen receptor-stimulated polyphosphoinositide hydrolysis in B cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2835989&form=6&db=m Cytoplasmic pH change induced by leukotriene B4 in human neutrophils. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2836504&form=6&db=m Selective modulation by guanine nucleotides of the high affinity subset of plasma membrane receptors for leukotriene B4 on human polymorphonuclear leukocytes. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2836511&form=6&db=m Mechanism involved in the mobilization of neutrophil calcium by 5-hydroxyeicosatetraenoate. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2838273&form=6&db=m Variations in guanine-binding proteins (Gs, Gi) in cultured bovine adrenal cells. Consequences on the effects of phorbol ester and angiotensin II on adrenocorticotropin-induced and cholera-toxin-induced cAMP production. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2838563&form=6&db=m Increased intracellular cyclic adenosine monophosphate inhibits T lymphocyte-mediated cytolysis by two distinct mechanisms. therapeutic application,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2840439&form=6&db=m Propionic acid-induced calcium mobilization in human neutrophils. ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2840571&form=6&db=m Regulation of follicle-stimulating hormone binding to receptors on bovine calf testis membranes by cholera toxin-sensitive guanine nucleotide binding protein. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2841152&form=6&db=m P2-purinoceptor-stimulated phosphoinositide turnover in chick myotubes. Calcium mobilization and the role of guanyl nucleotide-binding proteins. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2841544&form=6&db=m Does interleukin 2 stimulus-response coupling result in generation of intracellular second messengers? unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2844509&form=6&db=m Autoregulation of acute progesterone and adenosine 3',5'-monophosphate responses to follicle-stimulating hormone (FSH) in porcine granulosa cells: effects of FSH, cholera toxin, forskolin, and pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2846548&form=6&db=m Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2856941&form=6&db=m Pertussis toxin treatment blocks the inhibition of somatostatin and increases the stimulation by forskolin of cyclic AMP accumulation and adrenocorticotropin secretion from mouse anterior pituitary tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2875442&form=6&db=m Somatocrinin stimulates adenylate cyclase-Ns regulatory subunit in a GH3 cell-line: comparison with VIP. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2875997&form=6&db=m Association of a solubilized prostaglandin E2 receptor from renal medulla with a pertussis toxin-reactive guanine nucleotide regulatory protein. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2886351&form=6&db=m Role of a protein regulating guanine nucleotide binding in phosphoinositide breakdown and calcium mobilization by bradykinin in neuroblastoma X glioma hybrid NG108-15 cells: effects of pertussis toxin and cholera toxin on receptor-mediated signal transduction. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2887235&form=6&db=m Inositol phosphate formation and chloride current responses induced by acetylcholine and serotonin through GTP-binding proteins in Xenopus oocyte after injection of rat brain messenger RNA. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2891304&form=6&db=m Somatostatin inhibits cAMP-mediated cholinergic transmission in the myenteric plexus. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2902632&form=6&db=m Subunit S1 of pertussis toxin: mapping of the regions essential for ADP-ribosyltransferase activity. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2944002&form=6&db=m Endogenous ADP-ribosylation of Gs subunit and autonomous regulation of adenylate cyclase. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2946691&form=6&db=m Solubilization of the vasopressin receptor from rat liver plasma membranes. Evidence for a receptor X GTP-binding protein complex. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2947938&form=6&db=m Evidence for two different stimulatory adenylate cyclase coupling mechanisms in rat renal papilla. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2950093&form=6&db=m Cholera toxin blocks glucagon-mediated inhibition of the liver plasma membrane (Ca2+-Mg2+)-ATPase. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2982826&form=6&db=m Adenine nucleotides directly stimulate pertussis toxin. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2983701&form=6&db=m Pertussis but not cholera toxin inhibits the stimulated increase in actin association with the cytoskeleton in rabbit neutrophils: role of the "G proteins" in stimulus-response coupling. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2983985&form=6&db=m Solubilization from rat pancreatic plasma membranes of a cholecystokinin (CCK) agonist-receptor complex interacting with guanine nucleotide regulatory proteins coexisting in the same macromolecular system. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3005271&form=6&db=m Thyrotropin-releasing hormone activates a Ca2+-dependent polyphosphoinositide phosphodiesterase in permeable GH3 cells. GTP gamma S potentiation by a cholera and pertussis toxin-insensitive mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3009162&form=6&db=m Dexamethasone effects on beta-adrenergic receptors and adenylate cyclase regulatory proteins Gs and Gi in ROS 17/2.8 cells. therapeutic application,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3012078&form=6&db=m Effect of cholera toxin and pertussis toxin on opioid tolerance and dependence in the guinea-pig myenteric plexus. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3012529&form=6&db=m Reduced hormone-stimulated adenylate cyclase activity in NIH-3T3 cells expressing the EJ human bladder ras oncogene. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3015920&form=6&db=m Thyrotropin-releasing hormone stimulation of polyphosphoinositide hydrolysis in GH3 cell membranes is GTP dependent but insensitive to cholera or pertussis toxin. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3016048&form=6&db=m Inhibition of thyrotropin-stimulated adenosine 3',5'-monophosphate formation in rat thyroid cells by an adenosine analog. Evidence that the inhibition is mediated by the putative inhibitory guanine nucleotide regulatory protein. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3018082&form=6&db=m Characterization of the plasma membrane bound GTPase from rabbit neutrophils. I. Evidence for an Ni-like protein coupled to the formyl peptide, C5a, and leukotriene B4 chemotaxis receptors. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3019344&form=6&db=m Evidence that thyrotropin-releasing hormone-induced increases in GTPase activity and phosphoinositide metabolism in GH3 cells are mediated by a guanine nucleotide-binding protein other than Gs or Gi. ongoing research,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3023016&form=6&db=m Stimulation of luteinizing hormone (LH) release and phospholipid breakdown by guanosine triphosphate in permeabilized pituitary gonadotropes: antagonist action suggests association of a G protein and gonadotropin-releasing hormone receptor. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3025201&form=6&db=m Light activation of phospholipase A2 in rod outer segments of bovine retina and its modulation by GTP-binding proteins. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3025276&form=6&db=m NADP+ enhances cholera and pertussis toxin-catalyzed ADP-ribosylation of membrane proteins. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3026344&form=6&db=m Role of a pertussis toxin substrate in the control of lectin-induced cap formation in human neutrophils. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3030860&form=6&db=m A cholera toxin-sensitive G-protein stimulates exocytosis in sea urchin eggs. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3031036&form=6&db=m Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3032838&form=6&db=m Regulation of lens cyclic nucleotide metabolism by Ca2+ plus calmodulin. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3034674&form=6&db=m Insulin stimulates a novel GTPase activity in human platelets. therapeutic application,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3038542&form=6&db=m Thyrotropin effect on the availability of Ni regulatory protein in FRTL-5 rat thyroid cells to ADP-ribosylation by pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3038620&form=6&db=m A novel cholera toxin-sensitive G-protein (Gc) regulating receptor-mediated phosphoinositide signalling in human pituitary clonal cells. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3039339&form=6&db=m Heterologous regulations of cAMP responses in pregnant rat myometrium. Evolution from a stimulatory to an inhibitory prostaglandin E2 and prostacyclin effect. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3040818&form=6&db=m Insulin stimulation of cyclic AMP phosphodiesterase is independent from the G-protein pathways involved in adenylate cyclase regulation. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3091021&form=6&db=m Spermatozoa contain a guanine nucleotide-binding protein ADP-ribosylated by pertussis toxin. ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3097538&form=6&db=m GTP-binding proteins associated with serotonin-activated adenylate cyclase in Fasciola hepatica. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3099763&form=6&db=m Thrombin, unlike vasopressin, appears to stimulate two distinct guanine nucleotide regulatory proteins in human platelets. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3106961&form=6&db=m Deduced amino acid sequence of bovine retinal Go alpha: similarities to other guanine nucleotide-binding proteins. diagnostic usage,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3107555&form=6&db=m Multiple isoforms of ADP-ribosylated G-like proteins from mammalian thyroid membranes. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3113428&form=6&db=m A pertussis/cholera toxin sensitive G-protein may mediate vasopressin-induced inositol phosphate formation in smooth muscle cell. therapeutic application,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3114250&form=6&db=m Physical and functional association of follitropin receptors with cholera toxin-sensitive guanine nucleotide-binding protein. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3117058&form=6&db=m Dual role of GTP-binding proteins in the control of endothelial prostacyclin. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3120696&form=6&db=m Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from Gs, Gi and Go. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3120816&form=6&db=m Effects of insulin, pertussis toxin and cholera toxin on protein synthesis and diacylglycerol production in 3T3 fibroblasts: evidence for a G-protein mediated activation of phospholipase C in the insulin signal mechanism. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3122298&form=6&db=m Guanine nucleotide-binding proteins involved in transmembrane signaling. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3122742&form=6&db=m Modulation of tumor necrosis factor-alpha cytotoxicity in L929 cells by bacterial toxins, hydrocortisone and inhibitors of arachidonic acid metabolism. causal interaction,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3122750&form=6&db=m Pertussis and cholera toxin ADP-ribosylation in Dictyostelium discoideum membranes. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3125065&form=6&db=m Adenylate cyclase activity of v-ras-k transformed rat epithelial thyroid cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3134019&form=6&db=m GTP-binding proteins and adenylate cyclase activity in v-Ki-ras transformed NIH/3T3 fibroblast cells. ongoing research,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3135154&form=6&db=m Structural and functional relationships of guanosine triphosphate binding proteins. causal interaction,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3135838&form=6&db=m Cholera toxin and pertussis toxin substrates and endogenous ADP-ribosyltransferase activity in Drosophila melanogaster. ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3137562&form=6&db=m Platelet cytosolic 44-kDa protein is a substrate of cholera toxin-induced ADP-ribosylation and is not recognized by antisera against the alpha subunit of the stimulatory guanine nucleotide-binding regulatory protein. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3137927&form=6&db=m Opioid peptides promote cholera-toxin-catalysed ADP-ribosylation of the inhibitory guanine-nucleotide-binding protein (Gi) in membranes of neuroblastoma x glioma hybrid cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3139455&form=6&db=m Adipocyte plasma membranes contain two Gi subtypes but are devoid of Go. diagnostic usage,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3143845&form=6&db=m Developmental changes in the levels of substrates for cholera toxin-catalyzed and pertussis toxin-catalyzed ADP-ribosylation in rat cardiac cell membranes. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3145113&form=6&db=m G-proteins and egg activation. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3145679&form=6&db=m Role of guanine nucleotide regulatory proteins and inositol phosphates in the hormone induced mobilization of hepatocyte calcium. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3155263&form=6&db=m Adenosine diphosphate ribosylation of G proteins by pertussis and cholera toxin in isolated membranes. Different requirements for and effects of guanine nucleotides and Mg2+. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3181621&form=6&db=m The regulation of adenylate cyclase in liver membranes of lean and obese mice. therapeutic application,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3190695&form=6&db=m ADP-ribosylation of bovine S-antigen by cholera toxin. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3287141&form=6&db=m Peptide mapping studies of the pertussis toxin substrate in human neutrophils, platelets and erythrocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3320046&form=6&db=m Structural characterization of pertussis toxin A subunit. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3322408&form=6&db=m Ca2+-stimulated catecholamine release from alpha-toxin-permeabilized PC12 cells: biochemical evidence for exocytosis and its modulation by protein kinase C and G proteins. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3358757&form=6&db=m Neutrophil activation by surface bound IgG: pertussis toxin insensitive activation. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3383778&form=6&db=m Modulation of prolactin-stimulated Nb2 lymphoma cell mitogenesis by cholera toxin and pertussis toxin. ongoing research,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3390705&form=6&db=m Muscarinic receptor-mediated hydrolysis of phosphatidylinositols in human neuroblastoma (SH-SY5Y) cells is sensitive to pertussis toxin. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3420947&form=6&db=m Cytoskeletal alterations as a parameter for assessment of toxicity. therapeutic application,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3503532&form=6&db=m Enhancement of parathyroid hormone-responsive renal cortical adenylate cyclase activity by a cytosol protein activator from rat reticulocytes. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3537692&form=6&db=m Antibodies to the ras gene product inhibit adenylate cyclase and accelerate progesterone-induced cell division in Xenopus laevis oocytes. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3653036&form=6&db=m Decreased potency of glucagon on transformed-induced MDCK cells does not reflect an alteration of adenylate cyclase components. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3736664&form=6&db=m Botulinum C2 toxin ADP-ribosylates actin. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3856323&form=6&db=m Sequence of the alpha subunit of photoreceptor G protein: homologies between transducin, ras, and elongation factors. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3929781&form=6&db=m Pertussis toxin inhibits intracellular pH changes in human neutrophils stimulated by N-formyl-methionyl-leucyl-phenylalanine. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3936483&form=6&db=m Pertussis toxin substrate is a guanosine 5'-[beta-thio]diphosphate-, N-ethylmaleimide-, Mg2+- and temperature-sensitive GTP-binding protein. ongoing research,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6140642&form=6&db=m Islet-activating protein impairs alpha 2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6141934&form=6&db=m Human pancreatic tumor growth hormone (GH) - releasing factor and cyclic adenosine 3',5'- monophosphate evoke GH release from anterior pituitary cells: the effects of pertussis toxin, cholera toxin, forskolin, and cycloheximide. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6142883&form=6&db=m ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6199389&form=6&db=m Pertussis toxin actions on the pituitary-derived 235-1 clone: effects of PGE1, cholera toxin, and forskolin on cyclic AMP metabolism and prolactin release. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6310432&form=6&db=m Luteinizing hormone secretion is enhanced by pertussis toxin, cholera toxin, and forskolin. Evidence for the involvement of the cyclic AMP-generating system. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6329028&form=6&db=m Mono(adenosine diphosphate ribosyl) transferase in Xenopus tissues. Direct demonstration by a zymographic localization in sodium dodecyl sulfate--polyacrylamide gels. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6434346&form=6&db=m Oocyte adenylyl cyclase contains Ni, yet the guanine nucleotide-dependent inhibition by progesterone is not sensitive to pertussis toxin. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7473158&form=6&db=m Prostaglandin E2 contracts vascular smooth muscle and inhibits potassium currents in vascular smooth muscle cells of rat tail artery. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7479387&form=6&db=m Protein kinase C regulation of the adenylyl cyclase system in rat prostatic epithelium. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7489748&form=6&db=m Pertussis toxin-sensitive GTP-binding proteins regulate activation-induced apoptotic cell death of human natural killer cells. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7491918&form=6&db=m Effects of fluoride and cholera and pertussis toxins on sensory transduction in the carotid body. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7491958&form=6&db=m EGF inhibits secretagogue-induced cAMP production and amylase secretion by Gi proteins in pancreatic acini. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7511568&form=6&db=m Parathyroid hormone/adenylate cyclase coupling in vascular smooth muscle cells. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7523318&form=6&db=m Myeloid cell proliferation stimulated by Steel factor is pertussis toxin sensitive and enhanced by cholera toxin. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7530278&form=6&db=m Characterization of nitric oxide-stimulated ADP-ribosylation of various proteins from the mouse macrophage cell line ANA-1 using sodium nitroprusside and the novel nitric oxide-donating compound diethylamine dinitric oxide. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7533476&form=6&db=m Study of the activation mechanism of adriamycin on rat mast cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7556978&form=6&db=m Interleukin-1 beta inhibition of insulin release in rat pancreatic islets: possible involvement of G-proteins in the signal transduction pathway. causal interaction,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7557463&form=6&db=m Cloning and characterization of a G protein alpha-subunit-encoding gene from the basidiomycete, Coprinus congregatus. diagnostic usage,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7561109&form=6&db=m Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7578277&form=6&db=m Modulation by 1,25(OH)2-vitamin D3 of the adenylyl cyclase/cyclic AMP pathway in rat and chick myoblasts. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7592725&form=6&db=m Phosphatidic acid and lysophosphatidic acid induce haptotactic migration of human monocytes. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7607603&form=6&db=m Effect of cholera toxin and pertussis toxin on the growth of A431 cells: kinetics of cyclic AMP and inositol trisphosphate in toxin-treated cells. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7615693&form=6&db=m Trimeric G proteins regulate the cytosol-induced redistribution of Golgi enzymes into the endoplasmic reticulum. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7615808&form=6&db=m Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7642531&form=6&db=m A novel G protein alpha subunit containing atypical guanine nucleotide-binding domains is differentially expressed in a molluscan nervous system. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7647103&form=6&db=m 1,25(OH)2-vitamin D-3 stimulates phospholipase A2 activity via a guanine nucleotide-binding protein in chick myoblasts. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7648317&form=6&db=m AB5 toxins. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7651901&form=6&db=m Chicken liver contains a large quantity of a G-protein-linked neurotensin receptor. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7653652&form=6&db=m Pertussis toxin-sensitive G proteins mediate carbachol-induced REM sleep and respiratory depression. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7662986&form=6&db=m Single-cell analysis of macrophage chemotactic protein-1-regulated cytosolic Ca2+ increase in human adherent monocytes. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7664686&form=6&db=m A novel role for testicular descent; temperature-dependent induction of pertussis toxin-sensitive Gi protein function in postnatal rat Leydig cells. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7677848&form=6&db=m Release of guanosine triphosphate binding protein alpha subunits from mouse myocardial membranes: basic properties and their alterations in acute murine Chagas disease. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7678793&form=6&db=m Endothelin receptor subtypes are coupled to adenylate cyclase via different guanyl nucleotide-binding proteins in vasculature. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7681878&form=6&db=m Effect of adenylate cyclase stimulation on meiotic resumption and cyclic AMP content of zona-free and cumulus-enclosed bovine oocytes in vitro. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7688324&form=6&db=m Mast cell activation by pedicellarial toxin of sea urchin, Toxopneustes pileolus. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7691354&form=6&db=m The adenylyl cyclase-cyclic AMP system modulates morphological and functional development of hypothalamic beta-endorphin neurons in culture. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7708214&form=6&db=m Differential involvement of hippocampal G-protein subtypes in the memory process of rats. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7712007&form=6&db=m G-protein involvement in muscarinic receptor-stimulation of inositol phosphates in longitudinal smooth muscle from the small intestine of the guinea-pig. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7713868&form=6&db=m Platelet-activating factor stimulates transcription of the heparin-binding epidermal growth factor-like growth factor in monocytes. Correlation with an increased kappa B binding activity. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7733966&form=6&db=m Platelet activating factor activates MAPK and increases in intracellular calcium via independent pathways in B lymphocytes. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7762003&form=6&db=m The role of G-proteins in the activation of human leukocytes by particulate stimuli to produce reactive oxygen metabolites. ongoing research,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7764138&form=6&db=m Immunochemical detection of GTP-binding protein in cephalopod photoreceptors by anti-peptide antibodies. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7768328&form=6&db=m Stimulation of glycogenolysis by three locust adipokinetic hormones involves Gs and cAMP. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7792803&form=6&db=m Nongenomic aldosterone effects: the cell membrane as a specific target of mineralocorticoid action. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7797472&form=6&db=m Platelet-activating factor induces NF-kappa B activation through a G protein-coupled pathway. therapeutic application,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7805400&form=6&db=m Photosensitivity of the isolated pigment epithelium and arachidonic acid metabolism: preliminary results. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7813624&form=6&db=m Distinct mechanisms for Ca2+ entry induced by OKT3 and Ca2+ depletion in Jurkat T cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7813780&form=6&db=m Involvement of an inhibitory G-protein in the signal transduction pathway of maturation-inducing hormone (17 alpha,20 beta-dihydroxy-4-pregnen-3-one) action in rainbow trout (Oncorhynchus mykiss) oocytes. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7818993&form=6&db=m Effect of prenylcysteine analogues on chemoattractant receptor-mediated G protein activation. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7823085&form=6&db=m Modulation of Ca(2+)-channel currents by protein kinase C in adult rat sympathetic neurons. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7830559&form=6&db=m Common features of the NAD-binding and catalytic site of ADP-ribosylating toxins. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7843729&form=6&db=m Endothelin stimulates platelet-activating factor synthesis by cultured rat Kupffer cells. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7864172&form=6&db=m cAMP modulates transepithelial resistance response of LLC-PK1 renal epithelia to tumor necrosis factor. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7876108&form=6&db=m Stimulation of mitogen-activated protein kinase by thyrotropin in primary cultured human thyroid follicles. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7877138&form=6&db=m Sarafotoxin-induced calcium mobilization in cultured dog tracheal smooth muscle cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7878084&form=6&db=m Generation of inositol phosphates in bitter taste transduction. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7884323&form=6&db=m TNF-alpha stimulates increased plasma membrane guanine nucleotide binding protein activity in polymorphonuclear leukocytes. diagnostic usage,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7888304&form=6&db=m Evidence for expression of a Ras-like and a stage specific GTP binding homologous protein by Plasmodium falciparum. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7889122&form=6&db=m Cholera toxin can ADP-ribosylate Gs as well as Gi in ACTH-unresponsive human adrenocortical cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7898456&form=6&db=m Characterization of botulinum C3-catalyzed ADP-ribosylation of rho proteins and identification of mammalian C3-like ADP-ribosyltransferase. diagnostic usage,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7898466&form=6&db=m DeoxyNAD and deoxyADP-ribosylation of proteins. diagnostic usage,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7898487&form=6&db=m Alterations in G-proteins in congestive heart failure in cardiomyopathic (UM-X7.1) hamsters. causal interaction,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7900846&form=6&db=m Regulation of renal cortical Na-HCO3 cotransporter. II. Role of G proteins. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7908252&form=6&db=m Effects of pertussis and cholera toxins on alpha-adrenoceptor function in rat tail artery: differences in hypertension. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7908588&form=6&db=m Effects of pertussis and cholera toxin on the interferon-gamma stimulated immunocytochemical staining of ICAM-1 and inositol phosphate formation in a human renal carcinoma cell line. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7910371&form=6&db=m Contribution of ligand structure to activation of alpha 2-adrenergic receptor subtype coupling to Gs. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7915334&form=6&db=m Enhanced negative inotropic effect of an adenosine A1-receptor agonist in rat left atria in hypothyroidism. diagnostic usage,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7930624&form=6&db=m Thrombospondin promotes chemotaxis and haptotaxis of human peripheral blood monocytes. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7945328&form=6&db=m Possible involvement of GTP-binding proteins in 1 alpha,25-dihydroxyvitamin D3 induction of tissue transglutaminase in mouse peritoneal macrophages. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7947403&form=6&db=m Vasoactive intestinal polypeptide modulates GABAA receptor function through activation of cyclic AMP. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7956118&form=6&db=m Regulation of the CHAPS-solubilized muscarinic receptors by an inhibitory GTP binding protein (Gi) in the brain of neonatal and adult rats. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7956944&form=6&db=m Gonadotropin-releasing hormone (GnRH)-receptor coupling to inositol phosphate and prolactin production in GH3 cells stably transfected with rat GnRH receptor complementary deoxyribonucleic acid. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7964288&form=6&db=m Mastoparan, a wasp venom peptide, stimulates release of prolactin from cultured rat anterior pituitary cells. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7965816&form=6&db=m L-channel modulation by alpha-1 adrenoceptor activation in neonatal rat ventricular cells: intracellular mechanisms. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7966244&form=6&db=m Regulation by GTP of a Ca(2+)-activated K+ channel in the apical membrane of rabbit cortical collecting duct cells. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7971157&form=6&db=m Different G proteins are involved in the biphasic response of clonal rat pituitary cells to thyrotropin-releasing hormone. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7982455&form=6&db=m Effects of chronic receptor blockade on excitation-contraction coupling in rat aortic rings. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7984278&form=6&db=m The cloned human 5-HT1E receptor couples to inhibition and activation of adenylyl cyclase via two distinct pathways in transfected BS-C-1 cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7988431&form=6&db=m Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7991631&form=6&db=m Modulation of brain Na+ channels by a G-protein-coupled pathway. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8012277&form=6&db=m C5a stimulus-secretion coupling in rat basophilic leukaemia (RBL-2H3) cells transfected with the human C5a receptor is mediated by pertussis and cholera toxin-sensitive G proteins. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8014894&form=6&db=m Muscarine modulation by a G-protein alpha-subunit of delayed rectifier K+ current in rat ventromedial hypothalamic neurones. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8015650&form=6&db=m Regional characterization of G-protein subunits in glomeruli, cortices and medullas of the rat kidney. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8019756&form=6&db=m 5-Hydroxytryptamine receptor-mediated phosphoinositide hydrolysis in canine cultured tracheal smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8022777&form=6&db=m A membrane-delimited pathway of G-protein regulation of the guard-cell inward K+ channel. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8027031&form=6&db=m G-proteins modulate amiloride-sensitive sodium channels. ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8027566&form=6&db=m Functional specialization of fibronectin-binding beta 1-integrins in T lymphocyte migration. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8033585&form=6&db=m Role of G-proteins in ciliary process adenylyl cyclase responses of the albino rabbit eye. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8033592&form=6&db=m Endotoxins in cholera and pertussis toxins interfere with in vivo responses to these agents in the albino rabbit eye. ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8040088&form=6&db=m G-proteins coupled to phosphoinositide hydrolysis in the cochlear and vestibular sensory epithelia of the rat are insensitive to cholera and pertussis toxins. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8048473&form=6&db=m HSP-72 synthesis is promoted by increase in [Ca2+]i or activation of G proteins but not pHi or cAMP. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8049083&form=6&db=m Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8057394&form=6&db=m Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8059062&form=6&db=m Changes in cAMP formation in mononuclear leukocytes of heart and renal transplant recipients. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8069630&form=6&db=m AB5 ADP-ribosylating toxins: comparative anatomy and physiology. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8087932&form=6&db=m Age-related changes in beta-adrenergic neuroeffector systems in the human heart. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8088367&form=6&db=m Functional characterization of the Na(+)-H+ exchanger in rat mast cells: crosstalks between different kinase pathways. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8100988&form=6&db=m Somatostatin modulation of adenosine receptor coupled G-protein subunits in the caudate nucleus of the rat. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8118033&form=6&db=m Priming effects of granulocyte-macrophage colony-stimulating factor are coupled to cholera toxin-sensitive guanine nucleotide binding protein in human T lymphocytes. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8133273&form=6&db=m Endothelin- and sarafotoxin-induced phosphoinositide hydrolysis in cultured canine tracheal smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8134615&form=6&db=m Insulin-like growth factors enhance phagocytosis by human neutrophils in vitro. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8135760&form=6&db=m Stimulation of high-affinity GTPase activity and cholera toxin-catalysed [32P]ADP-ribosylation of Gi by lysophosphatidic acid (LPA) in wild-type and alpha 2C10 adrenoceptor-transfected Rat 1 fibroblasts. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8144937&form=6&db=m Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3. Similarities and differences with MCP-1. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8158247&form=6&db=m Opioids mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells. ongoing research,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8179336&form=6&db=m Effect of cholera toxin and pertussis toxin on prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinase production by human monocytes. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8180340&form=6&db=m Regulation of thrombin-induced endothelial cell activation by bacterial toxins. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8184904&form=6&db=m Regulation of G proteins by adenosine receptor agonist in coronary artery. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8192649&form=6&db=m Collagen type IV stimulates an increase in intracellular Ca2+ in pancreatic acinar cells via activation of phospholipase C. causal interaction,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8193581&form=6&db=m Involvement of G proteins in the effect of insulin-like growth factor I on gonadotropin-induced rat granulosa cell differentiation. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8196611&form=6&db=m Evidence that v-Src-induced phospholipase D activity is mediated by a G protein. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8203713&form=6&db=m Evidence for guanosine triphosphate--binding proteins in Trypanosoma cruzi. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8229757&form=6&db=m Platelet-activating factor (PAF) induces a contraction of isolated smooth muscle cells from guinea pig ileum: intracellular pathway involved. causal interaction,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8243300&form=6&db=m Cholera toxin and dibutyryl cyclic adenosine 3',5'-monophosphate sensitize gonadotropin-releasing hormone-stimulated inositol phosphate production to inhibition in protein kinase-C (PKC)-depleted cells: evidence for cross-talk between a cholera toxin-sensitive G-protein and PKC. therapeutic application,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8243309&form=6&db=m Estrogen uncouples beta-adrenergic receptor from the stimulatory guanine nucleotide-binding protein in female rat hypothalamus. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8253125&form=6&db=m Cholera toxin antagonizes morphine-induced catalepsy through a cyclic AMP-independent mechanism. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8253719&form=6&db=m Opposite coupling of prostaglandin E receptor EP3C with Gs and G(o). Stimulation of Gs and inhibition of G(o). ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8256656&form=6&db=m Tumor necrosis factor alpha modulates parathyroid hormone action in UMR-106-01 osteoblastic cells. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8282000&form=6&db=m G proteins in aortic endothelial cells and bradykinin-induced formation of nitric oxide. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8282011&form=6&db=m Extracellular ATP elevates cytoplasmatic free Ca2+ in HeLa cells by the interaction with a 5'-nucleotide receptor. therapeutic application,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8307964&form=6&db=m Conditional activation of cAMP signal transduction by protein kinase C. The effect of phorbol esters on adenylyl cyclase in permeabilized and intact cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8312135&form=6&db=m Age-dependent changes in transmembrane signalling: identification of G proteins in human lymphocytes and polymorphonuclear leukocytes. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8335362&form=6&db=m Mechanisms of nonopsonic phagocytosis of Pseudomonas aeruginosa. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8343499&form=6&db=m The GTP-binding regulatory proteins, Gs and G(i), are altered in erythrocyte membranes of patients with ischemic heart disease resulting from coronary atherosclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8351284&form=6&db=m Effects of cholera and pertussis toxins on prolactin stimulation of lactose synthesis and ornithine decarboxylase activity in mouse mammary gland explants. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8363615&form=6&db=m GTP-binding protein couples with metabotropic glutamate receptor in bovine retinal on-bipolar cell. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8380059&form=6&db=m Phosphoinositide metabolism in a polyoma-BK-virus-transformed pancreatic islet cell line: evidence for constitutively activated phospholipase C. causal interaction,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8380997&form=6&db=m Differential cholera-toxin- and pertussis-toxin-catalysed ADP-ribosylation of G-proteins coupled to formyl-peptide and leukotriene B4 receptors. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8381358&form=6&db=m Cholera toxin but not pertussis toxin inhibits angiotensin II-enhanced contractions in the rat portal vein. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8381837&form=6&db=m IL-8 induces the locomotion of human IL-2-activated natural killer cells. Involvement of a guanine nucleotide binding (Go) protein. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8382264&form=6&db=m Additive induction of Egr-1 (zif/268) mRNA expression in neuroblastoma x glioma hybrid NG108-15 cells via cholinergic muscarinic, alpha 2-adrenergic, and bradykinin receptors. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8382416&form=6&db=m Adjuvant action of cholera toxin and pertussis toxin in the induction of IgA antibody response to orally administered antigen. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383056&form=6&db=m Impaired G-proteins and cyclic nucleotide phosphodiesterase activity in T-lymphocytes from patients with sarcoidosis. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383428&form=6&db=m G protein activation inhibits amiloride-blockable highly selective sodium channels in A6 cells. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8384003&form=6&db=m Calcium- and G-protein-dependent activation of arachidonic acid release by concanavalin-A-stimulated mouse macrophages. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8385355&form=6&db=m Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8386608&form=6&db=m Cholera toxin and pertussis toxin provoke differential effects on luteinizing hormone release, inositol phosphate production, and gonadotropin-releasing hormone (GnRH) receptor binding in the gonadotrope: evidence for multiple guanyl nucleotide binding proteins in GnRH action. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8386609&form=6&db=m A cholera toxin-sensitive guanyl nucleotide binding protein mediates the movement of pituitary luteinizing hormone into a releasable pool: loss of this event is associated with the onset of homologous desensitization to gonadotropin-releasing hormone. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8386624&form=6&db=m Stimulatory and inhibitory guanine-nucleotide-binding regulatory protein involvement in stimulation of arachidonic-acid release by N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor from guinea-pig alveolar macrophages. Differential receptor/G-protein interaction assessed by pertussis and cholera toxins. therapeutic application,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8387140&form=6&db=m Platelet activating factor stimulates a receptor-coupled membrane GTPase in guinea pig eosinophils. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8389133&form=6&db=m Potentiation by cholera toxin of bradykinin-induced inositol phosphate production in the osteoblast-like cell line MC3T3-E1. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8392092&form=6&db=m Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8392802&form=6&db=m Effect of heat shock, [Ca2+]i, and cAMP on inositol trisphosphate in human epidermoid A-431 cells. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8396964&form=6&db=m An arginine residue is the site of receptor-stimulated, cholera toxin-catalysed ADP-ribosylation of pertussis toxin-sensitive G-proteins. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8398979&form=6&db=m Guanine nucleotide binding proteins mediate the chemotactic signal of transforming growth factor-beta 1 in rat IL-2 activated natural killer cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8406362&form=6&db=m Stimulation of mono-ADP ribosylation in rat liver plasma membranes after long-term alcohol intake. diagnostic usage,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8406588&form=6&db=m Requirements for Langerhans' cell depletion following in vitro exposure of murine skin to ultraviolet-B. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8410690&form=6&db=m M2 muscarinic receptor-mediated inhibition of the Ca2+ current in rat magnocellular cholinergic basal forebrain neurones. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8418893&form=6&db=m Identification of heterotrimeric and low molecular weight GTP-binding proteins in rabbit skeletal muscle longitudinal sarcoplasmic reticulum. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8419127&form=6&db=m Opposing influences of dexamethasone and retinoic acid on adenylate cyclase activity in ROS 17/2.8 cells. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8450714&form=6&db=m Characterization of vasopressin-mediated GSH efflux from Hep G2 cells: significance of protein kinase C. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8452756&form=6&db=m Differential effects of fluoride and a non-hydrolysable GTP analogue on adenylate cyclase and G-proteins in Ceratitis capitata neural tissue. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8479122&form=6&db=m Bilateral ureteral obstruction alters levels of the G-protein subunits G alpha s and G alpha q/11. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8484719&form=6&db=m G-protein from Medicago sativa: functional association to photoreceptors. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8510384&form=6&db=m Protein intake affects levels of G-protein subunits G alpha i2, G alpha i3, and G beta in rat glomerular membranes. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8546817&form=6&db=m Transcriptional regulation of Na/K-ATPase by corticosteroids, glycyrrhetinic acid and second messenger pathways in rat kidney epithelial cells. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8569708&form=6&db=m Characterization of the G protein involved in the muscarinic stimulation of adenylyl cyclase of rat olfactory bulb. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8569749&form=6&db=m Modulation of protein kinase C by adenosine: involvement of adenosine A1 receptor-pertussis toxin sensitive nucleotide binding protein system. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8592160&form=6&db=m A subtype of kappa-opioid receptor mediates inhibition of high-affinity GTPase inherent in Gi1 in guinea pig cerebellar membranes. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8593468&form=6&db=m Cholera toxin accentuates the antagonism by acetylcholine of higenamine-induced positive chronotropy is isolated right atria of mice. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8595931&form=6&db=m Regulation of superoxide anion generation in bovine alveolar macrophages by bacterial lipopolysaccharide, serum proteins, and modulators of signal transduction. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8611426&form=6&db=m Streptococcal glycoprotein-induced tumour cell growth inhibition involves the modulation of a pertussis toxin-sensitive G protein. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8612094&form=6&db=m Age-related changes in G proteins in rat aorta. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,3 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8612978&form=6&db=m A developmental role for the heterotrimeric G protein Go alpha in a migratory population of embryonic neurons. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8632341&form=6&db=m Somatostatin inhibits bombesin-stimulated Gi-protein via its own receptor in rabbit colonic smooth muscle cells. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8632357&form=6&db=m Sustained activation of phospholipase D via adenosine A3 receptors is associated with enhancement of antigen- and Ca(2+)-ionophore-induced secretion in a rat mast cell line. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8638712&form=6&db=m Gastrin stimulation of histamine synthesis in enterochromaffin-like cells from rabbit fundic mucosa. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647187&form=6&db=m Dissection of lymphocyte function-associated antigen 1-dependent adhesion and signal transduction in human natural killer cells shown by the use of cholera or pertussis toxin. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647918&form=6&db=m Neutrophil thrombospondin receptors are linked to GTP-binding proteins. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8662290&form=6&db=m Different endothelin receptor subtypes are involved in phospholipid signalling in the proximal tubule of rat kidney. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8664168&form=6&db=m Cholera toxin directly stimulates pregnenolone generation with increasing Ca2+ efflux in bovine adrenocortical mitochondria. causal interaction,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8667029&form=6&db=m Adenosine release and uptake in cerebellar granule neurons both occur via an equilibrative nucleoside carrier that is modulated by G proteins. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8678289&form=6&db=m Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8689388&form=6&db=m Mitoxantrone induces nonimmunological histamine release from rat mast cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8690252&form=6&db=m Multiplicative interaction between intrathecally and intracerebroventricularly administered morphine for antinociception in the mouse: effects of spinally and supraspinally injected 3-isobutyl-1-methylxanthine, cholera toxin, and pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8691524&form=6&db=m Extracellular matrix proteins are potent agonists of human smooth muscle cell migration. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8739246&form=6&db=m Beta-adrenoceptor mediated signal transduction in congestive heart failure in cardiomyopathic (UM-X7.1) hamsters. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8748073&form=6&db=m Morphine stimulates phagocytosis of Mycobacterium tuberculosis by human microglial cells: involvement of a G protein-coupled opiate receptor. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8752494&form=6&db=m [Involvement of G proteins between receptors and KCa channels in the regulation of airway tone by the autonomic nervous system] therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8768693&form=6&db=m Angiotensin II-mediated activation of L-type calcium channels involves phosphatidylinositol hydrolysis-independent activation of protein kinase C in rat portal vein myocytes. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8770167&form=6&db=m Albumin endocytosis is regulated by heterotrimeric GTP-binding protein G alpha i-3 in opossum kidney cells. causal interaction,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8784077&form=6&db=m Coupling of gonadotropin-releasing hormone receptor to Gi protein in human reproductive tract tumors. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8786295&form=6&db=m Effects of nicotine on the immune response. II. Chronic nicotine treatment induces T cell anergy. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8794831&form=6&db=m Thromboxane A2 mediates the stimulation of inositol 1,4,5-trisphosphate production and intracellular calcium mobilization by bradykinin in neonatal rat ventricular cardiomyocytes. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8864565&form=6&db=m Thromboxane A2 agonist modulation of excitatory synaptic transmission in the rat hippocampal slice. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8874810&form=6&db=m Potentiation by higenamine of the aconitine-induced positive chronotropic effect in isolated right atria of mice: the effects of cholera toxin, forskolin and pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8883034&form=6&db=m Calcium entry stimulated by swelling of Madin-Darby canine kidney cells. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8884779&form=6&db=m Noradrenergic potentiation of cerebellar Purkinje cell responses to GABA: cyclic AMP as intracellular intermediary. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8890457&form=6&db=m D2L, D2S, and D3 dopamine receptors stably transfected into NG108-15 cells couple to a voltage-dependent potassium current via distinct G protein mechanisms. ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8890934&form=6&db=m Regulation of bradykinin-induced Ins(1,4,5)P3 formation by protein kinase C in human fibroblasts. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8897834&form=6&db=m TXA2 agonists inhibit high-voltage-activated calcium channels in rat hippocampal CA1 neurons. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8898087&form=6&db=m Galectin-3 stimulates uptake of extracellular Ca2+ in human Jurkat T-cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8898093&form=6&db=m Evidence that Arg-295, Glu-378, and Glu-380 are active-site residues of the ADP-ribosyltransferase activity of iota toxin. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8905470&form=6&db=m Regulation of mouse placental lactogen secretion by G proteins before midpregnancy. ongoing research,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8908595&form=6&db=m Regulation of melanoma cell adhesion stabilization to fibronectin. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8948324&form=6&db=m Theileria parva sporozoite entry into bovine lymphocytes involves both parasite and host cell signal transduction processes. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8952700&form=6&db=m 24,25-(OH)2D3 regulates protein kinase C through two distinct phospholipid-dependent mechanisms. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8955177&form=6&db=m Preferential involvement of Go and Gz proteins in mediating rat natural killer cell lysis of allogeneic and tumor target cells. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8957696&form=6&db=m Voltage-dependent calcium channels and Gi regulatory protein mediate the human sperm acrosomal exocytosis induced by N-acetylglucosaminyl/mannosyl neoglycoproteins. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8968332&form=6&db=m Potentiation of the glycine-activated Cl- current by ethanol in cultured mouse spinal neurons. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8968547&form=6&db=m The P2Y purinoceptor in rat brain microvascular endothelial cells couple to inhibition of adenylate cyclase. ongoing research,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8971917&form=6&db=m Could dual G-protein coupling explain [D-Met2]FMRFamide's mixed action in vivo? causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8973553&form=6&db=m Characterization of heterotrimeric G-proteins in adult Acanthocheilonema viteae. diagnostic usage,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8980284&form=6&db=m Interleukin-1beta-induced inhibition of hair growth in vitro is mediated by cyclic AMP. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9015861&form=6&db=m Functional reconstitution of detergent-solubilized bovine calf testis luteinizing hormone/chorionic gonadotropin receptor into phospholipid vesicles. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9029482&form=6&db=m Interactions of alpha-melanotropin and agouti on B16 melanoma cells: evidence for inverse agonism of agouti. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9038845&form=6&db=m Effect of in vivo injection of cholera and pertussis toxin on glucose transport in rat skeletal muscle. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9042382&form=6&db=m An examination of the relationship between mu-opioid antinociceptive efficacy and G-protein coupling using pertussis and cholera toxins. diagnostic usage,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9113103&form=6&db=m Inhibition of swine microglial cell phagocytosis of Cryptococcus neoformans by femtomolar concentrations of morphine. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9137989&form=6&db=m The antineoplastic drug vinorelbine activates non-immunological histamine release from rat mast cells. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9139796&form=6&db=m Induction of promiscuous G protein coupling of the follicle-stimulating hormone (FSH) receptor: a novel mechanism for transducing pleiotropic actions of FSH isoforms. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9139798&form=6&db=m Luteinizing hormone/choriogonadotropin-dependent, cholera toxin-catalyzed adenosine 5'-diphosphate (ADP)-ribosylation of the long and short forms of Gs alpha and pertussis toxin-catalyzed ADP-ribosylation of Gi alpha*. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9147032&form=6&db=m Effects of spinally and supraspinally injected 3-isobutyl-1-methylxanthine, cholera toxin, and pertussis toxin on cold water swimming stress-induced antinociception in the mouse. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9151292&form=6&db=m Histamine H1 receptors in C6 glial cells are coupled to calcium-dependent potassium channels via release of calcium from internal stores. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9161717&form=6&db=m Modulation of sperm acrosomal exocytosis by guanyl nucleotides and G-protein-modifier agents. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9171237&form=6&db=m Regulation of G(q/11)alpha by the gonadotropin-releasing hormone receptor. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9193638&form=6&db=m ADP-ribosylation and early transcription regulation by bacteriophage T4. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9193642&form=6&db=m Sequence and structural links between distant ADP-ribosyltransferase families. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9234783&form=6&db=m Coexistence of CD14-dependent and independent pathways for stimulation of human monocytes by gram-positive bacteria. therapeutic application,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9243514&form=6&db=m Second-messenger regulation of receptor association with clathrin-coated pits: a novel and selective mechanism in the control of CD4 endocytosis. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9256158&form=6&db=m Protein tyrosine kinase involvement in the production of superoxide anion by neutrophils exposed to Aroclor 1242, a mixture of polychlorinated biphenyls. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9262330&form=6&db=m Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9267411&form=6&db=m Pneumocystis carinii infection alters GTP-binding proteins in the lung. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9273995&form=6&db=m Quartz crystal microbalance investigation of the interaction of bacterial toxins with ganglioside containing solid supported membranes. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9288146&form=6&db=m Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9299566&form=6&db=m The heterotrimeric GTP-binding protein, GS, modulates the Cl- conductance of rat parotid acinar secretory granules. ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9307112&form=6&db=m Modulation of Ca2+ currents by various G protein-coupled receptors in sympathetic neurons of male rat pelvic ganglia. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9310437&form=6&db=m Muscarinic receptor activation modulates Ca2+ channels in rat intracardiac neurons via a PTX- and voltage-sensitive pathway. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9348283&form=6&db=m Homotypic lysosome fusion in macrophages: analysis using an in vitro assay. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9351890&form=6&db=m G-protein regulation of an L-type calcium channel current in canine jejunal circular smooth muscle. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9395453&form=6&db=m Muscarinic receptor-mediated dual regulation of ADP-ribosyl cyclase in NG108-15 neuronal cell membranes. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9397950&form=6&db=m A comparative study of the role of adenylate cyclase in the release of adrenocorticotropin from the ovine and rat anterior pituitary. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9401738&form=6&db=m Mastoparan-induced apoptosis of cultured cerebellar granule neurons is initiated by calcium release from intracellular stores. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9469461&form=6&db=m Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9486126&form=6&db=m Adenylyl cyclase is involved in desensitization and recovery of ATP-stimulated Cl- secretion in MDCK cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9503335&form=6&db=m Novel mechanism for non-genomic action of 17 beta-oestradiol on kainate-induced currents in isolated rat CA1 hippocampal neurones. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9519806&form=6&db=m Characterization of a streptococcal antitumor glycoprotein (SAGP). ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9537596&form=6&db=m Melatonin receptors in benign prostate epithelial cells: evidence for the involvement of cholera and pertussis toxins-sensitive G proteins in their signal transduction pathways. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9589368&form=6&db=m Calcium mobilization and protease-activated receptor cleavage after thrombin stimulation in motor neurons. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9595304&form=6&db=m Vanadate changes Ca2+ influx pathway properties in human red blood cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9623766&form=6&db=m Resistance of the insulinotropic action of alpha-D-glucose and beta-L-glucose pentaacetates to cholera and pertussis toxins. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9655176&form=6&db=m Endothelin-1 and insulin activate the steady-state voltage dependent R-type Ca2+ channel in aortic smooth muscle cells via a pertussis toxin and cholera toxin sensitive G-protein. ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9655882&form=6&db=m 3H-naloxone benzoylhydrazone binding in MOR-1-transfected Chinese hamster ovary cells: evidence for G-protein-dependent antagonist binding. causal interaction,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9665286&form=6&db=m Blood mononuclear cell production of TNF-alpha and IL-8: engagement of different signal transduction pathways including the p42 MAP kinase pathway. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9674691&form=6&db=m Cellular mechanisms of melatonin action. diagnostic usage,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9687565&form=6&db=m Selective activation of a chimeric Gi1/Gs G protein alpha subunit by the human IP prostanoid receptor: analysis using agonist stimulation of high affinity GTPase activity and [35S]guanosine-5'-O-(3-thio)triphosphate binding. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9688329&form=6&db=m Secretoneurin and chemoattractant receptor interactions. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9704103&form=6&db=m Novel molecular biology approaches to acellular vaccines. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9783906&form=6&db=m Heterotrimeric G-protein candidates for Ge in the ACTH secretory pathway. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9789057&form=6&db=m HIV-1 Tat protein mimicry of chemokines. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9832140&form=6&db=m Presynaptic inhibition by concanavalin A: are alpha-latrotoxin receptors involved in action potential-dependent transmitter release? ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9838061&form=6&db=m Anaphylatoxins C5a and C3a induce nuclear factor kappaB activation in human peripheral blood monocytes. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9846160&form=6&db=m cAMP-dependent inhibition is dominant in regulating superoxide production in the bone-resorbing osteoclasts. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9914412&form=6&db=m beta-adrenergic modulation of maxi-K channels in vascular smooth muscle via Gi through a membrane-delimited pathway. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9925353&form=6&db=m Differential alterations in left and right ventricular G-proteins in congestive heart failure due to myocardial infarction. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10027878&form=6&db=m The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10028933&form=6&db=m Mechanism of endothelial nitric oxide-dependent vasorelaxation induced by wine polyphenols in rat thoracic aorta. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10067836&form=6&db=m Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10087453&form=6&db=m Inhibition of hormonally induced inositol trisphosphate production in Transfected GH4C1 cells: A novel role for the D5 subtype of the dopamine receptor. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10217527&form=6&db=m Bradykinin-induced phosphoinositide hydrolysis and Ca2+ mobilization in canine cultured tracheal epithelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10218977&form=6&db=m The role of protein kinases A and C pathways in the regulation of mitogen-activated protein kinase activation in response to gonadotropin-releasing hormone receptor activation. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10344528&form=6&db=m G protein coupling of CGS 21680 binding sites in the rat hippocampus and cortex is different from that of adenosine A1 and striatal A2A receptors. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10358189&form=6&db=m Purine metabolites suppress proliferation of human NK cells through a lineage-specific purine receptor. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10375012&form=6&db=m Inhibition of protein phosphatase 2A (PP2A) mimics suckling-induced sensitization of mammotropes: involvement of a pertussis toxin (PTX) sensitive G-protein and the adenylate cyclase (AC). ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419564&form=6&db=m Kainate receptors coupled to G(i)/G(o) proteins in the rat hippocampus. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10429189&form=6&db=m Adenosine inhibits the renal plasma-membrane (Ca2+ + Mg2+)-ATPase through a pathway sensitive to cholera toxin and sphingosine. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10484618&form=6&db=m Mechanism(s) of activation of secretory phospholipase A(2)s in mouse keratinocytes. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10506488&form=6&db=m cAMP-independent dilation of coronary arterioles to adenosine : role of nitric oxide, G proteins, and K(ATP) channels. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10515959&form=6&db=m Vasopressin and amastatin induce V(1)-receptor-mediated suppression of excitatory transmission in the rat parabrachial nucleus. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10548476&form=6&db=m Light activation of phosphatidylethanolamine N-methyltransferase in rod outer segments and its modulation by association states of transducin. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10646518&form=6&db=m Membrane-bound form of ADP-ribosyl cyclase in rat cortical astrocytes in culture. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10674988&form=6&db=m Functional and molecular characterization of VIP receptor--effector system in rat developing immunocompetent cells: G protein involvement. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10794500&form=6&db=m Blockage of amyloid beta peptide-induced cytosolic free calcium by fullerenol-1, carboxylate C60 in PC12 cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10822176&form=6&db=m Functional compartments in rat mast cells for cAMP and calcium on histamine release. diagnostic usage,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10837821&form=6&db=m Differential modulatory roles of cholera toxin and pertussis toxin in the regulation of pain responses induced by excitatory amino acids administered intrathecally in mice. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10867539&form=6&db=m G proteins regulate calcium channels in the luminal membranes of the rabbit nephron. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10898948&form=6&db=m Effect of light on phosphatidate phosphohydrolase activity of retina rod outer segments: the role of transducin. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10901171&form=6&db=m Differential effects of cholera toxin and pertussis toxin on the c-fos and c-jun mRNA expression in rat C6 glioma cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10989285&form=6&db=m Activation of particulate guanylate cyclase by adrenomedullin in cultured SV-40 transformed cat iris sphincter smooth muscle (SV-CISM-2) cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11041451&form=6&db=m The thyrotropin receptor is not involved in the activation of p42/p44 mitogen-activated protein kinases by thyrotropin preparations in Chinese hamster ovary cells expressing the human thyrotropin receptor. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11056210&form=6&db=m Different stimulatory opioid effects on intracellular Ca(2+) in SH-SY5Y cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11083899&form=6&db=m Activation of A(3) adenosine receptor induces calcium entry and chloride secretion in A(6) cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11086221&form=6&db=m Insulinotropic toxins as molecular probes for analysis of glucagon-likepeptide-1 receptor-mediated signal transduction in pancreatic beta-cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11116326&form=6&db=m Structural evidence for the evolution of pyrogenic toxin superantigens. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11124161&form=6&db=m Differential alterations in cardiac adrenergic signaling in chronic hypoxia or norepinephrine infusion. diagnostic usage,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11146421&form=6&db=m Neurotensin modulates the electrical activity of frog pituitary melanotropes via activation of a G-protein-coupled receptor pharmacologically related to both the NTS1 and nts2 receptors of mammals. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11159838&form=6&db=m Stimulation of mitogen-activated protein kinase by gonadotropin-releasing hormone in human granulosa-luteal cells. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11161002&form=6&db=m Melanocortin receptor-mediated mobilization of intracellular free calcium in HEK293 cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11202610&form=6&db=m Effects of S-nitroso-cysteine on proteins that regulate exocytosis in PC12 cells: inhibitory effects on translocation of synaptophysin and ADP-ribosylation of GTP-binding proteins. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11223431&form=6&db=m Low-density lipoprotein (LDL) binds to a G-protein coupled receptor in human platelets. Evidence that the proaggregatory effect induced by LDL is modulated by down-regulation of binding sites and desensitization of its mediated signaling. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245606&form=6&db=m G protein coupling to M1 and M3 muscarinic receptors in sublingual glands. diagnostic usage,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11257510&form=6&db=m Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Galpha(s) and Galpha(i)/Galpha(o) activation. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11259610&form=6&db=m Nootropic drug modulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11295169&form=6&db=m Endothelin-1 receptors on cultured rat articular chondrocytes: regulation by age, growth factors, and cytokines, and effect on cAMP production. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11295234&form=6&db=m The comparative analysis of proenkephalin mRNA expression induced by cholera toxin and pertussis toxin in primary cultured rat cortical astrocytes. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11299208&form=6&db=m Pregnancy enhances G protein activation and nitric oxide release from uterine arteries. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11301058&form=6&db=m Neuropeptide FF receptors couple to a cholera toxin-sensitive G-protein in rat dorsal raphe neurones. ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11315999&form=6&db=m Endogenous prostaglandin E2 and insulin-like growth factor 1 can modulate the levels of parathyroid hormone receptor in human osteoarthritic osteoblasts. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11319726&form=6&db=m Vascular insulin/insulin-like growth factor-1 resistance in female obese Zucker rats. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11353812&form=6&db=m Prostaglandin F(2alpha) receptor-dependent regulation of prostaglandin transport. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11397545&form=6&db=m Differential roles of spinal cholera toxin- and pertussis toxin-sensitive G proteins in nociceptive responses caused by formalin, capsaicin, and substance P in mice. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11449818&form=6&db=m FMS*Calciumfluor increases alkaline phosphatase expression during osteogenesis in vitro of tibia-derived rat osteoblasts by activation of G alpha 0/G alpha i proteins. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11483409&form=6&db=m Mechanisms of bradykinin-mediated Ca(2+) signalling in canine cultured corneal epithelial cells. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11489454&form=6&db=m 5-HT1A receptor-mediated activation of G-protein-gated inwardly rectifying K+ current in rat periaqueductal gray neurons. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11550977&form=6&db=m Granulocyte-macrophage colony stimulating factor activates proteoglycan, type II collagen, and cAMP production by rat articular chondrocytes through specific binding sites. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11597896&form=6&db=m ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11607369&form=6&db=m Guanine nucleotide binding protein involvement in early steps of phytochrome-regulated gene expression. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11697895&form=6&db=m Involvement of heterotrimeric G proteins in phagocytosis and recycling from the phagosomal compartment. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11725002&form=6&db=m Further Elucidation of a Pertussis Toxin-Sensitive Transmembrane Signaling Mechanism Involved in Central alpha(2)-Adrenoceptor Activation in the Rat. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11725063&form=6&db=m Subtypes of Guanine-Nucleotide-Binding Regulatory Proteins at the Locus coeruleus Involved in Fentanyl-Induced Muscular Rigidity in the Rat. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11726708&form=6&db=m Relationship between the self-incompatibility and cAMP level in Lilium longiflorum. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11824374&form=6&db=m Mg(++)-induced endothelial cell migration: substratum selectivity and receptor-involvement. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11827704&form=6&db=m OxLDL upregulates CXCR2 expression in monocytes via scavenger receptors and activation of p38 mitogen-activated protein kinase. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11835758&form=6&db=m Mechanism of macrophage injury following traumatic hemorrhagic shock: through PTX-sensitive G-protein-mediated signal transduction pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11855746&form=6&db=m Differential effects of bacterial toxins on mitogenic actions of sodium fluoride and those of aluminum fluoride in human TE85 osteosarcoma cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11861323&form=6&db=m Stimulation of beta(3)-adrenoceptors causes phosphorylation of p38 mitogen-activated protein kinase via a stimulatory G protein-dependent pathway in 3T3-L1 adipocytes. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11873241&form=6&db=m Lysophosphatidic acid augments fibroblast-mediated contraction of released collagen gels. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11882676&form=6&db=m Prostaglandin E(2) inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11956157&form=6&db=m Activation of 5-HT(7) receptor in rat glomerulosa cells is associated with an increase in adenylyl cyclase activity and calcium influx through T-type calcium channels. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12030802&form=6&db=m Pretreatment with cholera or pertussis toxin differentially modulates morphine- and beta-endorphin-induced antinociception in the mouse formalin test. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12063164&form=6&db=m Transforming growth factor-beta1 regulation of growth zone chondrocytes is mediated by multiple interacting pathways. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12065896&form=6&db=m Characterization of bradykinin receptors in canine cultured corneal epithelial cells: pharmacological and functional studies. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12075624&form=6&db=m Adenylyl cyclase and G-proteins in Phytomonas. therapeutic application,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12106434&form=6&db=m Endothelin-evoked Release of Arachidonic Acid from Mouse Astrocytes in Primary Culture. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12324626&form=6&db=m Evidence for G-Protein Regulation of Inward K+ Channel Current in Guard Cells of Fava Bean. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12369781&form=6&db=m Involvement of Rho and p38 MAPK in endothelin-1-induced expression of PGHS-2 mRNA in osteoblast-like cells. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12471617&form=6&db=m Wnt-5a and G-protein signaling are required for collagen-induced DDR1 receptor activation and normal mammary cell adhesion. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12531644&form=6&db=m B- and T-cell responses to the mycobacterium surface antigen PstS-1 in the respiratory tract and adjacent tissues. Role of adjuvants and routes of immunization. diagnostic usage,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12569410&form=6&db=m Nod factors activate both heterotrimeric and monomeric G-proteins in Vigna unguiculata (L.) Walp. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12591092&form=6&db=m Activation of muscarinic m5 receptors inhibits recombinant KCNQ2/KCNQ3 K+ channels expressed in HEK293T cells. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12595757&form=6&db=m Bradykinin B2 receptor-mediated proliferation via activation of the Ras/Raf/MEK/MAPK pathway in rat vascular smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12654855&form=6&db=m Mucosal immunization with a genetically engineered pertussis toxin S1 fragment-cholera toxin subunit B chimeric protein. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12655177&form=6&db=m A novel G protein alpha subunit in embryo of the ascidian, Halocynthia roretzi. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12742067&form=6&db=m Evidence that the appressorial development in barley powdery mildew is controlled by MAP kinase activity in conjunction with the cAMP pathway. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12753074&form=6&db=m Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12810818&form=6&db=m OxLDL induces mitogen-activated protein kinase activation mediated via PI3-kinase/Akt in vascular smooth muscle cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883412&form=6&db=m G-protein activation decreases isoflurane inhibition of N-type Ba2+ currents. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12888188&form=6&db=m Effects of spinally and supraspinally injected 3-isobutyl-1-methylxanthine, cholera toxin, and pertussis toxin on immobilization stress-induced antinociception in the mouse. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12916739&form=6&db=m Biphasic modulation of voltage-dependent currents of retinal cones by cannabinoid CB1 receptor agonist WIN 55212-2. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566001&form=6&db=m Hyperosmolar solution effects in guinea pig airways. III. Studies on the identity of epithelium-derived relaxing factor in isolated perfused trachea using pharmacological agents. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14594552&form=6&db=m Attenuation of changes in G(i)-proteins and adenylyl cyclase in heart failure by an ACE inhibitor, imidapril. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14596931&form=6&db=m Pertussis toxin-sensitive Galphai protein and ERK-dependent pathways mediate ultrasound promotion of osteogenic transcription in human osteoblasts. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14672813&form=6&db=m Dopamine-induced synaptic depression in the parabrachial nucleus is independent of CTX- and PTX-sensitive G-proteins, PKA and PLC signalling pathways. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14975356&form=6&db=m Suramin has adjuvant properties and promotes expansion of antigen-specific Th1 and Th2 cells in vivo. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15008743&form=6&db=m Involvement of signal transducing GTP-binding proteins in renal artery alpha 1-adrenoceptor mediated smooth muscle contraction. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15041999&form=6&db=m Evidence for tight coupling of Gi protein-mediated lysophosphatidic acid receptor to stimulated cytokine production in ovarian cancer cell. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15125661&form=6&db=m Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15245434&form=6&db=m Human leukocyte elastase induces keratinocyte proliferation by epidermal growth factor receptor activation. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15265766&form=6&db=m Gialpha3 protein-coupled dopamine D3 receptor-mediated inhibition of renal NHE3 activity in SHR proximal tubular cells is a PLC-PKC-mediated event. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15265811&form=6&db=m Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15374752&form=6&db=m PGE2 increases the tetrodotoxin-resistant Nav1.9 sodium current in mouse DRG neurons via G-proteins. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15383304&form=6&db=m Entamoeba invadens contains the components of a classical adrenergic signaling system. ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15520494&form=6&db=m Pertussis toxin-sensitive G protein modulates the ability of histamine to stimulate cAMP production in the chick pineal gland. ongoing research,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15840934&form=6&db=m [The effect of G protein regulator on pollen germination and [Ca2+]i variation in Pyrus serotina Rehd. pollen.] ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15857684&form=6&db=m Biochemical demonstration of mu-opioid receptor association with Gsalpha: enhancement following morphine exposure. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15974446&form=6&db=m Differential modulatory effects of cholera toxin and pertussis toxin on pain behavior induced by TNF-alpha, interleukin-1beta and interferon-gamma injected intrathecally. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16085656&form=6&db=m Characterization of phosphatidylinositol-specific phospholipase C (PI-PLC) from Lilium daviddi pollen. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16162176&form=6&db=m The signaling pathway in photoresponses that may be mediated by visual pigments in erythrophores of Nile tilapia. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16164753&form=6&db=m Metallothionein mediates leukocyte chemotaxis. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16210594&form=6&db=m Modulation of CD4 Th cell differentiation by ganglioside GD1a in vitro. ongoing research,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16390708&form=6&db=m Gi protein-mediated translocation of serine/threonine phosphatase to the plasma membrane and apoptosis of ovarian cancer cell in response to gonadotropin-releasing hormone antagonist cetrorelix. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16480614&form=6&db=m [The role of different subtypes of G protein in the secretory function of macrophages stimulated by activated complement following severe burn injury] unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16627471&form=6&db=m ADP-ribosyltransferase-specific modification of human neutrophil peptide-1. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16740995&form=6&db=m Endothelin 1 stimulates beta1Pix-dependent activation of Cdc42 through the G(salpha) pathway. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16751412&form=6&db=m TLR2 transmodulates monocyte adhesion and transmigration via Rac1- and PI3K-mediated inside-out signaling in response to Porphyromonas gingivalis fimbriae. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16899559&form=6&db=m Cell-surface expression, progestin binding, and rapid nongenomic signaling of zebrafish membrane progestin receptors alpha and beta in transfected cells. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16917518&form=6&db=m Molecular characterization of a G protein alpha-subunit-encoding gene from Mucor circinelloides. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17047412&form=6&db=m The effects of phorbol 12-myristate 13-acetate, cholera toxin, prostaglandin E2 and norepinephrine on inducible nitric oxide synthase activation induced by lipopolysaccharide in C6 cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17119919&form=6&db=m Beta(2)-Adrenergic activation increases glycogen synthesis in L6 skeletal muscle cells through a signalling pathway independent of cyclic AMP. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202153&form=6&db=m Gbetagamma dimers released in response to thyrotropin activate phosphoinositide 3-kinase and regulate gene expression in thyroid cells. ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18211822&form=6&db=m Activation of PKCbeta(II) and PKCtheta is essential for LDL-induced cell proliferation of human aortic smooth muscle cells via Gi-mediated Erk1/2 activation and Egr-1 upregulation. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18425627&form=6&db=m Effects of G protein and cGMP on phytochrome-mediated amaranthin synthesis inAmaranthus caudatus seedlings. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18566521&form=6&db=m Activation of endothelial nitric oxide synthase by proanthocyanidin-rich fraction from Croton celtidifolius (Euphorbiaceae): involvement of extracellular calcium influx in rat thoracic aorta. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18571589&form=6&db=m The role of G proteins in thromospondin-1-induced vascular smooth muscle cell migration. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18583341&form=6&db=m Activation of Galpha (i) and subsequent uncoupling of receptor-Galpha(i) signaling by Pasteurella multocida toxin. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758503&form=6&db=m Nonpeptidic antagonists of ETA and ETB receptors reverse the ET-1-induced sustained increase of cytosolic and nuclear calcium in human aortic vascular smooth muscle cells. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18793614&form=6&db=m cAMP imaging of cells treated with pertussis toxin, cholera toxin, and anthrax edema toxin. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19168957&form=6&db=m Mucosal vaccination approach against mosquito-borne Japanese encephalitis virus. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19452232&form=6&db=m Involvement of signaling pathways in bovine sperm motility, and effect of ergot alkaloids. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19709567&form=6&db=m Inhibition of renal Na+-ATPase activity by inosine is mediated by A1 receptor-induced inhibition of the cAMP signaling pathway. therapeutic application,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19912780&form=6&db=m Bradykinin modulates the electrophysiology of cultured rat sensory neurons through a pertussis toxin-insensitive G protein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20435598&form=6&db=m Cellular Basis for Bimatoprost Effects on Human Conventional Outflow. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20513179&form=6&db=m Evaluation of activation of G proteins in response to thyroid stimulating hormone in thyroid gland cells from euthyroid and hyperthyroid cats. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20605053&form=6&db=m Importance of CCL2-CCR2A/2B signaling for monocyte migration into spheroids of breast cancer-derived fibroblasts. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21429300&form=6&db=m cAMP antagonizes ERK-dependent antiapoptotic action of insulin. therapeutic application,unassigned 4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21625605&form=6&db=m Human glycolipid transfer protein (GLTP) expression modulates cell shape. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21781791&form=6&db=m Chronic ethanol promotes the neuronal differentiation of NG108-15 cells independently of toxin-sensitive G-proteins. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21784058&form=6&db=m Guanine-induced inhibition of renal Na(+)-ATPase activity: Evidence for the involvement of the Gi protein-coupled receptor. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22010988&form=6&db=m Identification of Novel Competing ?(2)AR Phospho-Extracellular Signal Regulated Kinase 1/2 Signaling Pathways in Human Trabecular Meshwork Cells. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22069594&form=6&db=m Toxins-useful biochemical tools for leukocyte research. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22207084&form=6&db=m Rapid membrane responses to dihydrotestosterone are sex dependent in growth plate chondrocytes. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22339216&form=6&db=m Bacteria and their toxins tamed for immunotherapy. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22754560&form=6&db=m mADP-RTs: versatile virulence factors from bacterial pathogens of plants and mammals. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23388886&form=6&db=m Coupling factor 6 enhances the spontaneous microaggregation of platelets by decreasing cytosolic cAMP irrespective of antiplatelet therapy. diagnostic usage,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25218563&form=6&db=m Effect of pertussis and cholera toxins administered supraspinally on CA3 hippocampal neuronal cell death and the blood glucose level induced by kainic acid in mice. ongoing research,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25694144&form=6&db=m Label-free detection and identification of protein ligands captured by receptors in a polymerized planar lipid bilayer using MALDI-TOF MS. diagnostic usage,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25741585&form=6&db=m Nuclear membrane R-type calcium channels mediate cytosolic ET-1-induced increase of nuclear calcium in human vascular smooth muscle cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26007235&form=6&db=m G?s proteins activate p72(Syk) and p60-c-Src tyrosine kinases to mediate sickle red blood cell adhesion to endothelium via LW-?v?3 and CD44-CD44 interactions. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26022362&form=6&db=m The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26560437&form=6&db=m Guanosine triphosphate can directly regulate cortisol production by activating Ca(2+)-messenger systems in bovine adrenal fasciculata cells. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26835606&form=6&db=m Rapid high mass resolution mass spectrometry using matrix-assisted ionization. diagnostic usage,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26843606&form=6&db=m G?14 subunit-mediated inhibition of voltage-gated Ca2+ and K+ channels via neurokinin-1 receptors in rat celiac-superior mesenteric ganglion neurons. causal interaction,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27038931&form=6&db=m Stromal Cell-Derived Factor 1 Increases Tetrodotoxin-Resistant Sodium Currents Nav1.8 and Nav1.9 in Rat Dorsal Root Ganglion Neurons via Different Mechanisms. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27048097&form=6&db=m Bacterial type AB? enterotoxins--structure, function and mechanism of action. ongoing research,unassigned 2,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27065246&form=6&db=m Ionomycin induces prostaglandin E2 formation in murine osteoblastic MC3T3-E1 cells via mechanisms independent of its ionophoric nature. ongoing research,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27237973&form=6&db=m G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28888984&form=6&db=m Cannabidiol, a novel inverse agonist for GPR12. therapeutic application,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29537197&form=6&db=m EFFECT OF PEPTIDOGLYCANE OF STAPHYLOCOCCUS AUREUS CELL WALL ON THE MECHANISM OF REGULATION OF CONTRACTILE ACTIVITY OF RAT MYOMETRIUM BY ADENYLATE CYCLASE SYSTEM. unassigned - 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31102582&form=6&db=m PARPs and PAR as novel pharmacological targets for the treatment of stress granule-associated disorders. causal interaction,unassigned 1,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31494202&form=6&db=m Identification of novel phytocannabinoids from Ganoderma by label-free dynamic mass redistribution assay. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33363467&form=6&db=m Anti-Inflammatory Effect of Geniposide on Regulating the Functions of Rheumatoid Arthritis Synovial Fibroblasts via Inhibiting Sphingosine-1-Phosphate Receptors1/3 Coupling G?i/G?s Conversion. therapeutic application,unassigned 3,0 2.4.2.30 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34064136&form=6&db=m Expression of Bordetella pertussis Antigens Fused to Different Vectors and Their Effectiveness as Vaccines. unassigned - 2.4.2.30 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20349137&form=6&db=m Recombinant human PDCD5 sensitizes chondrosarcomas to cisplatin chemotherapy in vitro and in vivo. unassigned - 2.4.2.30 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27618007&form=6&db=m BL-038, a Benzofuran Derivative, Induces Cell Apoptosis in Human Chondrosarcoma Cells through Reactive Oxygen Species/Mitochondrial Dysfunction and the Caspases Dependent Pathway. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28744712&form=6&db=m Vacuolar Protein Sorting 4B (VPS4B) Regulates Apoptosis of Chondrocytes via p38 Mitogen-Activated Protein Kinases (MAPK) in Osteoarthritis. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29782347&form=6&db=m Current questions in bone sarcomas. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31312595&form=6&db=m Sensitization of chondrosarcoma cells with PARP inhibitor and high-LET radiation. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31810230&form=6&db=m Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.4.2.30 Chordoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20386502&form=6&db=m Blockage of Stat3 With CDDO-Me Inhibits Tumor Cell Growth in Chordoma. unassigned - 2.4.2.30 Chordoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23893747&form=6&db=m Histone deacetylase inhibitors as potential therapeutic approaches for chordoma: An immunohistochemical and functional analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,1,4 2.4.2.30 Chordoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27002766&form=6&db=m PARP1 is a novel independent prognostic factor for the poor prognosis of chordoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Chordoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30322893&form=6&db=m Identification of therapeutic targets in chordoma through comprehensive genomic and transcriptomic analyses. causal interaction,unassigned 4,0 2.4.2.30 Chordoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30967556&form=6&db=m Defective homologous recombination DNA repair as therapeutic target in advanced chordoma. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Chordoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31201471&form=6&db=m Combination of PARP inhibitor and temozolomide to suppress chordoma progression. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18772339&form=6&db=m Overexpression of NANOG in gestational trophoblastic diseases: effect on apoptosis, cell invasion, and clinical outcome. therapeutic application,unassigned 1,0 2.4.2.30 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23486608&form=6&db=m PARP expression in germ cell tumours. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.4.2.30 Ciliopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31802371&form=6&db=m Analysis from the perspective of cilia: the protective effect of PARP inhibitors on visual function during light-induced damage. ongoing research,unassigned 1,0 2.4.2.30 Cleft Palate http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33854442&form=6&db=m Alteration of DNA Damage Response Causes Cleft Palate. unassigned - 2.4.2.30 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9607915&form=6&db=m Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice. unassigned - 2.4.2.30 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12954769&form=6&db=m Poly(ADP-ribosyl)ation accelerates DNA repair in a pathway dependent on Cockayne syndrome B protein. causal interaction,unassigned 3,0 2.4.2.30 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16107709&form=6&db=m Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress. unassigned - 2.4.2.30 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23229313&form=6&db=m PARP and CSB modulate the processing of transcription-mediated DNA strand breaks. unassigned - 2.4.2.30 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25440052&form=6&db=m Linking DNA damage, NAD(+)/SIRT1, and aging. unassigned - 2.4.2.30 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27624574&form=6&db=m PARP10 deficiency manifests by severe developmental delay and DNA repair defect. causal interaction,unassigned 4,0 2.4.2.30 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27791127&form=6&db=m Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA. causal interaction,unassigned 3,0 2.4.2.30 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30266807&form=6&db=m Poly(ADP-ribose) polymerase 1 (PARP1) promotes oxidative stress-induced association of Cockayne syndrome group B protein with chromatin. causal interaction,unassigned 1,0 2.4.2.30 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2572561&form=6&db=m Lethal infection by Bordetella pertussis mutants in the infant mouse model. causal interaction,unassigned 2,0 2.4.2.30 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9557631&form=6&db=m Activation of caspases in pig kidney cells infected with wild-type and CrmA/SPI-2 mutants of cowpox and rabbitpox viruses. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11961668&form=6&db=m C-terminal deletion mutant p21(WAF1/CIP1) enhances E2F-1-mediated apoptosis in colon adenocarcinoma cells. diagnostic usage,unassigned 3,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10960365&form=6&db=m Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12123754&form=6&db=m GPI 6150, a PARP inhibitor, reduces the colon injury caused by dinitrobenzene sulfonic acid in the rat. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12359959&form=6&db=m Poly(ADP-ribose) polymerase is a regulator of chemokine production: relevance for the pathogenesis of shock and inflammation. ongoing research,unassigned 1,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12570705&form=6&db=m Poly(ADP-ribose) polymerase inhibitors. causal interaction,unassigned 4,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12782201&form=6&db=m Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15554929&form=6&db=m Activator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15599708&form=6&db=m 5-Aminoisoquinolinone reduces colon injury by experimental colitis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15864271&form=6&db=m Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026317&form=6&db=m Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies. causal interaction,unassigned 3,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16310767&form=6&db=m Treatment with PARP-1 inhibitors, GPI 15427 or GPI 16539, ameliorates intestinal damage in rat models of colitis and shock. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16979620&form=6&db=m Effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase, in a mouse model of acute pancreatitis induced by cerulein. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17374531&form=6&db=m PARP inhibition reduces acute colonic inflammation in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17430191&form=6&db=m Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20204057&form=6&db=m Upregulation of Salmonella-induced IL-6 production in Caco-2 cells by PJ-34, PARP-1 inhibitor: involvement of PI3K, p38 MAPK, ERK, JNK, and NF-kappaB. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20633699&form=6&db=m Poly(ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications. causal interaction,unassigned 3,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20936357&form=6&db=m The Peri-appendiceal Red Patch in Ulcerative Colitis: Review of the University of Chicago Experience. causal interaction,unassigned 1,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23489378&form=6&db=m Beyond dna repair,the immunological role of parp-1 and its siblings. therapeutic application,unassigned 4,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24444779&form=6&db=m Attenuation of the progression of adjuvant-induced arthritis by 3-aminobenzamide treatment. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26912654&form=6&db=m Transcriptional reprogramming and resistance to colonic mucosal injury in Poly(ADP-ribose) polymerase 1 (PARP1)-deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33376516&form=6&db=m Poly(ADP-ribose) polymerase-1 inhibitor ameliorates dextran sulfate sodium-induced colitis in mice by regulating the balance of Th17/Treg cells and inhibiting the NF-?B signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17374531&form=6&db=m PARP inhibition reduces acute colonic inflammation in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34230120&form=6&db=m DNA Repair Protein Expression and Oxidative/Nitrosative Stress in Ulcerative Colitis and Sporadic Colorectal Cancer. therapeutic application,unassigned 1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9635838&form=6&db=m Absence of stimulation of poly(ADP-ribose) polymerase activity in patients predisposed to colon cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10100720&form=6&db=m Detection of poly(ADP-ribose) polymerase cleavage in response to treatment with topoisomerase I inhibitors: a potential surrogate end point to assess treatment effectiveness. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10815928&form=6&db=m Photodynamic therapy with the phthalocyanine photosensitizer Pc 4 of SW480 human colon cancer xenografts in athymic mice. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11309352&form=6&db=m Induction of apoptosis in colon cancer cells by cyclooxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11388704&form=6&db=m Prodigiosin-induced apoptosis in human colon cancer cells. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11494135&form=6&db=m Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-a methylester photosensitization. unassigned - 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12168847&form=6&db=m Tumor necrosis factor-alpha induces apoptosis associated with poly(ADP-ribose) polymerase cleavage in HT-29 colon cancer cells. therapeutic application,unassigned 2,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16157217&form=6&db=m TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16715131&form=6&db=m Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis. therapeutic application,unassigned 1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809434&form=6&db=m Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17260186&form=6&db=m Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice. ongoing research,unassigned 2,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18006925&form=6&db=m DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. ongoing research,unassigned 2,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20107900&form=6&db=m Fish fatty acids alter markers of apoptosis in colorectal adenoma and adenocarcinoma cell lines but fish consumption has no impact on apoptosis-induction ex vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20421936&form=6&db=m Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20559012&form=6&db=m Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study. diagnostic usage,unassigned 3,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21400612&form=6&db=m Functional characterization of peroxisome proliferator-activated receptor-?/? expression in colon cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21570414&form=6&db=m Common fragile sites in colon cancer cell lines: role of mismatch repair, RAD51 and poly(ADP-ribose) polymerase-1. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21732360&form=6&db=m The pro-apoptotic effect of quercetin in cancer cell lines requires ER?-dependent signals. therapeutic application,unassigned 1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21763418&form=6&db=m Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation. unassigned - 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22179721&form=6&db=m Methylseleninic acid potentiates multiple types of cancer cells to ABT-737-induced apoptosis by targeting Mcl-1 and Bad. ongoing research,unassigned 4,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22194930&form=6&db=m Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22230687&form=6&db=m Patulin induces colorectal cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation. ongoing research,unassigned 3,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22409967&form=6&db=m Dimeric 3,5-bis(benzylidene)-4-piperidones: A novel cluster of tumour-selective cytotoxins possessing multidrug-resistant properties. ongoing research,unassigned 1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22523035&form=6&db=m Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth. causal interaction,diagnostic usage,unassigned 3,1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22564437&form=6&db=m Acriflavine enhances radiosensitivity of colon cancer cells through endoplasmic reticulum stress-mediated apoptosis. causal interaction,unassigned 3,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22971663&form=6&db=m Cytotoxic effects of Echinacea purpurea flower extracts and cichoric acid on human colon cancer cells through induction of apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23054213&form=6&db=m The PARP inhibitor ABT-888 synergizes irinotecan treatment of colon cancer cell lines. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23330808&form=6&db=m Melatonin potentiates the antiproliferative and pro-apoptotic effects of ursolic acid in colon cancer cells by modulating multiple signaling pathways. unassigned - 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23411276&form=6&db=m Vitexin-2-O-xyloside, raphasatin and (-)-epigallocatechin-3-gallate synergistically affect cell growth and apoptosis of colon cancer cells. diagnostic usage,unassigned 1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23636450&form=6&db=m MSH3 expression does not influence the sensitivity of colon cancer HCT116 cell line to oxaliplatin and poly(ADP-ribose) polymerase (PARP) inhibitor as monotherapy or in combination. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23652727&form=6&db=m Inhibition of arginine ADP-ribosyltransferase 1 reduces the expression of poly(ADP-ribose) polymerase-1 in colon carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23653048&form=6&db=m Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23737956&form=6&db=m Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells. unassigned - 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23832862&form=6&db=m 8-Oxo-7,8-dihydroguanine and uric acid as efficient predictors of survival in colon cancer patients. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24372557&form=6&db=m Periostin induces chemoresistance in colon cancer cells through activation of the PI3K/Akt/survivin pathway. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24577941&form=6&db=m The use of olaparib (AZD2281) potentiates SN-38 cytotoxicity in colon cancer cells by indirect inhibition of Rad51-mediated repair of DNA double-strand breaks. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,4,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24643130&form=6&db=m Capsaicin Mediates Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells via Stabilizing and Activating p53. ongoing research,unassigned 3,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24922661&form=6&db=m The steroidal Na+/K+ ATPase inhibitor 3-[(R)-3-pyrrolidinyl]oxime derivative (3-R-POD) induces potent pro-apoptotic responses in colonic tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24930757&form=6&db=m Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25526641&form=6&db=m PARP-1 expression is increased in colon adenoma and carcinoma and correlates with OGG1. causal interaction,diagnostic usage,unassigned 4,1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25738796&form=6&db=m Downregulation of NIT2 inhibits colon cancer cell proliferation and induces cell cycle arrest through the caspase-3 and PARP pathways. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25809558&form=6&db=m Benzo[b]tryptanthrin inhibits MDR1, topoisomerase activity, and reverses adriamycin resistance in breast cancer cells. therapeutic application,unassigned 1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25817730&form=6&db=m Adenosine induces apoptosis through TNFR1/RIPK1/P38 axis in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26257651&form=6&db=m Simultaneous inhibition of ATR and PARP sensitizes colon cancer cell lines to irinotecan. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27060664&form=6&db=m Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol. ongoing research,unassigned 2,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27064876&form=6&db=m Human colon cancer HT-29 cell death responses to doxorubicin and Morus Alba leaves flavonoid extract. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27197561&form=6&db=m Expression of an Oncogenic BARD1 Splice Variant Impairs Homologous Recombination and Predicts Response to PARP-1 Inhibitor Therapy in Colon Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27922674&form=6&db=m 2'-Hydroxycinnamaldehyde induces apoptosis through HSF1-mediated BAG3 expression. unassigned - 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27923905&form=6&db=m ?-Lapachone Inhibits Lung Metastasis of Colorectal Cancer by Inducing Apoptosis of CT26 Cells. causal interaction,unassigned 1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27959393&form=6&db=m CD44-shRNA recombinant adenovirus inhibits cell proliferation, invasion, and migration, and promotes apoptosis in HCT116 colon cancer cells. diagnostic usage,unassigned 1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29434895&form=6&db=m Dihydroartemisinin increases apoptosis of colon cancer cells through targeting Janus kinase 2/signal transducer and activator of transcription 3 signaling. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29512707&form=6&db=m Apigenin induces apoptosis by suppressing Bcl-xl and Mcl-1 simultaneously via signal transducer and activator of transcription 3 signaling in colon cancer. therapeutic application,unassigned 1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29611024&form=6&db=m Anticancer effect of fermented Insampaedok-san in human colon cancer cells: a pilot study. therapeutic application,unassigned 1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29724012&form=6&db=m Frondoside A Enhances the Anti-Cancer Effects of Oxaliplatin and 5-Fluorouracil on Colon Cancer Cells. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30190788&form=6&db=m Terpenes from essential oils and hydrolate of Teucrium alopecurus triggered apoptotic events dependent on caspases activation and PARP cleavage in human colon cancer cells through decreased protein expressions. ongoing research,unassigned 1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31489353&form=6&db=m Chemical characterization and biological activity data for a novel indirubin derivative, LDD-1819. ongoing research,unassigned 3,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31558316&form=6&db=m Ipatasertib sensitizes colon cancer cells to TRAIL-induced apoptosis through ROS-mediated caspase activation. therapeutic application,unassigned 1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31903985&form=6&db=m ERCC1, PARP-1, and AQP1 as predictive biomarkers in colon cancer patients receiving adjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32283836&form=6&db=m Epigallocatechin-3-Gallate Induces Apoptosis as a TRAIL Sensitizer via Activation of Caspase 8 and Death Receptor 5 in Human Colon Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32774160&form=6&db=m Transgelin interacts with PARP1 in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33495297&form=6&db=m Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1 immunotherapy in colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33576344&form=6&db=m Identification of PARP-1 in cancer stem cells of gastrointestinal cancers: A preliminary study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33771894&form=6&db=m Correction: Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1- immunotherapy in colon cancer. therapeutic application,unassigned 3,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33820798&form=6&db=m SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS-STING Activation and Chemotherapeutic Sensitivity in Colon Cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.4.2.30 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11129260&form=6&db=m Effect of acidic environment and p53 on apoptosis induction by hyperthermia. ongoing research,unassigned 2,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15940627&form=6&db=m Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809031&form=6&db=m Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809434&form=6&db=m Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17562258&form=6&db=m [Inhibitory effect of 5-aminoisoquinolinone on PARP activity in colon carcinoma cell line HT-29] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18006925&form=6&db=m DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. ongoing research,unassigned 2,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19331692&form=6&db=m New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells. ongoing research,unassigned 2,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19468250&form=6&db=m Poly(ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19507186&form=6&db=m Radiosensitization of HT-29 cells and xenografts by the nitric oxide donor DETANONOate. ongoing research,unassigned 1,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20712901&form=6&db=m A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. unassigned - 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21285347&form=6&db=m MSH3 Mediates Sensitization of Colorectal Cancer Cells to Cisplatin, Oxaliplatin, and a Poly(ADP-ribose) Polymerase Inhibitor. therapeutic application,unassigned 3,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21300766&form=6&db=m MRE11 Deficiency Increases Sensitivity to Poly(ADP-ribose) Polymerase Inhibition in Microsatellite Unstable Colorectal Cancers. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21590040&form=6&db=m Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22122467&form=6&db=m Temozolomide: Mechanisms of Action, Repair and Resistance. therapeutic application,unassigned 1,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22864776&form=6&db=m Colorectal cancers differ in respect of PARP-1 protein expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23042038&form=6&db=m PARP6, a mono(ADP-ribosyl) transferase and a negative regulator of cell proliferation, is involved in colorectal cancer development. unassigned - 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23430444&form=6&db=m Polymorphisms in genes of APE1, PARP1, and XRCC1: risk and prognosis of colorectal cancer in a Northeast Chinese population. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23540347&form=6&db=m In Vitro and In Vivo Enhancement of Chemoradiation Using the Oral PARP Inhibitor ABT-888 in Colorectal Cancer Cells. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24203816&form=6&db=m Two DNA repair gene polymorphisms on the risk of gastrointestinal cancers: a meta-analysis. causal interaction,unassigned 3,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24215868&form=6&db=m Poly (ADP-ribose) polymerase inhibitor LT-626: Sensitivity correlates with MRE11 mutations and synergizes with platinums and irinotecan in colorectal cancer cells. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24870775&form=6&db=m Novel mutations of the PARP-1 gene associated with colorectal cancer in the Saudi population. causal interaction,unassigned 3,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24931875&form=6&db=m The depletion of securin enhances butein-induced apoptosis and tumor inhibition in human colorectal cancer. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25120693&form=6&db=m XRCC2 rs3218536 polymorphism decreases the sensitivity of colorectal cancer cells to poly(ADP-ribose) polymerase 1 inhibitor. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25207720&form=6&db=m Luteolin induces apoptosis in BE colorectal cancer cells by downregulating calpain, UHRF1, and DNMT1 expressions. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25268610&form=6&db=m Effect of APE1 T2197G (Asp148Glu) polymorphism on APE1, XRCC1, PARP1 and OGG1 expression in patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25526472&form=6&db=m XRCC2 promotes colorectal cancer cell growth, regulates cell cycle progression, and apoptosis. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25685067&form=6&db=m Treatment with the PARP inhibitor, niraparib, sensitizes colorectal cancer cell lines to irinotecan regardless of MSI/MSS status. therapeutic application,unassigned 4,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26543375&form=6&db=m Combined olaparib and oxaliplatin inhibits tumor proliferation and induces G2/M arrest and ?-H2AX foci formation in colorectal cancer. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26807313&form=6&db=m Sildenafil inhibits the growth of human colorectal cancer in vitro and in vivo. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27694308&form=6&db=m Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27746584&form=6&db=m The Effect of Poly(ADP-ribose) Polymerase-1 Gene 3'Untranslated Region Polymorphism in Colorectal Cancer Risk among Saudi Cohort. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27902462&form=6&db=m The synthetic lethal killing of RAD54B-deficient colorectal cancer cells by PARP1 inhibition is enhanced with SOD1 inhibition. causal interaction,unassigned 2,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28049506&form=6&db=m Novel derivative of aminobenzenesulfonamide (3c) induces apoptosis in colorectal cancer cells through ROS generation and inhibits cell migration. causal interaction,unassigned 2,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28182994&form=6&db=m ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28302009&form=6&db=m Expression and Single Nucleotide Polymorphism of Poly (ADPRibose) Polymerase-1 in Gastrointestinal Tumours: Clinical Involvement. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28457970&form=6&db=m HOXD8 exerts a tumor-suppressing role in colorectal cancer as an apoptotic inducer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28659575&form=6&db=m Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29579325&form=6&db=m A phase 2 study of the PARP inhibitor veliparib plus temozolomide in patients with heavily pretreated metastatic colorectal cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29632181&form=6&db=m PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,1 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29684585&form=6&db=m Nogo-B (Reticulon-4B) functions as a negative regulator of the apoptotic pathway through the interaction with c-FLIP in colorectal cancer cells. therapeutic application,unassigned 1,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29880585&form=6&db=m MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30211553&form=6&db=m Reactive Oxygen Species and p53 Mediated Activation of p38 and Caspases is Critically Involved in Kaempferol Induced Apoptosis in Colorectal Cancer Cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30237848&form=6&db=m MACROD2 deletions cause impaired PARP1 activity and chromosome instability in colorectal cancer. causal interaction,diagnostic usage,unassigned 1,1,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30353615&form=6&db=m Poly(ADP-Ribose) Polymerase Inhibition Sensitizes Colorectal Cancer-Initiating Cells to Chemotherapy. causal interaction,diagnostic usage,unassigned 4,4,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30597956&form=6&db=m Ursolic Acid Induces Apoptosis in Colorectal Cancer Cells Partially via Upregulation of MicroRNA-4500 and Inhibition of JAK2/STAT3 Phosphorylation. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30612311&form=6&db=m Sensitization of colorectal cancer to irinotecan therapy by PARP inhibitor rucaparib. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30883102&form=6&db=m Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31060309&form=6&db=m Quantitative Proteomics Identifies DNA Repair as a Novel Biological Function for Hepatocyte Nuclear Factor 4? in Colorectal Cancer Cells. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31516745&form=6&db=m Identification of anticancer drugs to radiosensitise BRAF-wild-type and mutant colorectal cancer. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31523195&form=6&db=m BRD4 Inhibitor AZD5153 Suppresses the Proliferation of Colorectal Cancer Cells and Sensitizes the Anticancer Effect of PARP Inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31831554&form=6&db=m A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32036006&form=6&db=m Combination Therapy with Radiation and PARP Inhibition Enhances Responsiveness to Anti-PD-1 Therapy in Colorectal Tumor Models. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32392194&form=6&db=m [PARP10 Influences the Proliferation of Colorectal Carcinoma Cells, a Preliminary Study]. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32435397&form=6&db=m From PARP1 to TNKS2 Inhibition: A Structure-Based Approach. therapeutic application,unassigned 3,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32629177&form=6&db=m Dual inhibition of VEGF and PARP suppresses KRAS-mutant colorectal cancer. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32799124&form=6&db=m Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33297377&form=6&db=m p53 Enhances Artemisia annua L. Polyphenols-Induced Cell Death Through Upregulation of p53-Dependent Targets and Cleavage of PARP1 and Lamin A/C in HCT116 Colorectal Cancer Cells. unassigned - 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33519476&form=6&db=m Alkannin-Induced Oxidative DNA Damage Synergizes With PARP Inhibition to Cause Cancer-Specific Cytotoxicity. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33531658&form=6&db=m Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51. ongoing research,unassigned 2,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33572475&form=6&db=m Post-Transcriptional Regulation of PARP7 Protein Stability Is Controlled by Androgen Signaling. causal interaction,unassigned 3,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33589588&form=6&db=m Glycogen synthase kinase 3? inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34148137&form=6&db=m ATMIN Suppresses Metastasis by Altering the WNT-Signaling Pathway via PARP1 in MSI-High Colorectal Cancer. therapeutic application,unassigned 1,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34196862&form=6&db=m ASO Author Reflections: ATMIN Altering the WNT Signaling Pathway via PARP1 in MSI-High Colorectal Cancer. unassigned - 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34230120&form=6&db=m DNA Repair Protein Expression and Oxidative/Nitrosative Stress in Ulcerative Colitis and Sporadic Colorectal Cancer. therapeutic application,unassigned 1,0 2.4.2.30 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34318678&form=6&db=m PARP-Targeted Auger Therapy in p53 Mutant Colon Cancer Xenograft Mouse Models. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Colorectal Neoplasms, Hereditary Nonpolyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22122467&form=6&db=m Temozolomide: Mechanisms of Action, Repair and Resistance. therapeutic application,unassigned 1,0 2.4.2.30 Colorectal Neoplasms, Hereditary Nonpolyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29650809&form=6&db=m [Molecular Targeted Therapies for Hereditary Cancer Syndrome]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Colorectal Neoplasms, Hereditary Nonpolyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29866945&form=6&db=m The Importance of Distinguishing Sporadic Cancers from Those Related to Cancer Predisposing Germline Mutations. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9204866&form=6&db=m Pertussis toxin: transition state analysis for ADP-ribosylation of G-protein peptide alphai3C20. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Congenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21507396&form=6&db=m Association of sperm morphology and the sperm deformity index (SDI) with poly (ADP-ribose) polymerase (PARP) cleavage inhibition. unassigned - 2.4.2.30 Congenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31464433&form=6&db=m Calcium Alleviates Fluoride-Induced Bone Damage by Inhibiting Endoplasmic Reticulum Stress and Mitochondrial Dysfunction. unassigned - 2.4.2.30 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6541517&form=6&db=m Effect of pertussis toxin on normorphine-dependence and on acute inhibitory effects of normorphine and clonidine in guinea-pig isolated ileum. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24218022&form=6&db=m Effects of cannabinoids on tension induced by acetylcholine and choline in slow skeletal muscle fibers of the frog. ongoing research,unassigned 1,0 2.4.2.30 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23040216&form=6&db=m Relationship between NADPH oxidase p22phox C242T, PARP-1 Val762Ala polymorphisms, angiographically verified coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus. causal interaction,diagnostic usage,unassigned 3,1,0 2.4.2.30 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29184509&form=6&db=m therapeutic application,unassigned 1,0 2.4.2.30 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29968072&form=6&db=m Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32411727&form=6&db=m DNA Damage, an Innocent Bystander in Atrial Fibrillation and Other Cardiovascular Diseases? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32757651&form=6&db=m Poly(ADP-Ribose) Polymerase Activity and Coronary Artery Disease in Type 2 Diabetes Mellitus: An Observational and Bidirectional Mendelian Randomization Study. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.4.2.30 Coronary Occlusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29968072&form=6&db=m Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32632359&form=6&db=m Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33051211&form=6&db=m Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity. therapeutic application,unassigned 1,0 2.4.2.30 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8176718&form=6&db=m Responses to Bordetella pertussis mutant strains and to vaccination in the coughing rat model of pertussis. unassigned - 2.4.2.30 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8637142&form=6&db=m Prevalence and incidence of adult pertussis in an urban population. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9109163&form=6&db=m Comparative efficacy of acellular pertussis vaccines: an analysis of recent trials. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10803256&form=6&db=m [Humoral reaction to Bordetella pertussis antigens: pertussis toxin, filamentous hemagglutinin and lipopolysaccharide in children with clinical symptoms of whooping cough. II. Occurence and level of B. pertussis antigens in children with suspected whooping cough] diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12925096&form=6&db=m Determination of pertactin IgG antibodies for the diagnosis of pertussis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1 2.4.2.30 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16755471&form=6&db=m Measures to control an outbreak of pertussis in a neonatal intermediate care nursery after exposure to a healthcare worker. diagnostic usage,unassigned 3,0 2.4.2.30 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22956654&form=6&db=m Antibody responses to individual Bordetella pertussis fimbrial antigens Fim2 or Fim3 following immunisation with five component acellular pertussis vaccine or disease. therapeutic application,unassigned 1,0 2.4.2.30 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24444146&form=6&db=m Poly(ADP-ribose) polymerase inhibition with HYDAMTIQ reduces allergen-induced asthma-like reaction, bronchial hyper-reactivity and airway remodelling. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27614887&form=6&db=m Parents as source of pertussis transmission in hospitalized young infants. diagnostic usage,unassigned 2,0 2.4.2.30 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32454030&form=6&db=m Chemotherapy directly followed by poly(ADP-ribose) polymerase inhibition as an alternative to surgery in patients with BRCA-mutated ovarian cancer: a potential management strategy in the era of coronavirus disease 2019. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32511303&form=6&db=m Coronavirus and PARP expression dysregulate the NAD Metabolome: a potentially actionable component of innate immunity. ongoing research,unassigned 2,0 2.4.2.30 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33063092&form=6&db=m Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33301988&form=6&db=m Covid-19 pathogenesis in prostatic cancer and TMPRSS2-ERG regulatory genetic pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.4.2.30 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33467912&form=6&db=m The potential association between PARP14 and SARS-CoV-2 infection (COVID-19). causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33494667&form=6&db=m Role of Poly(ADP-ribose) Polymerase (PARP1) in Viral Infection and its Implication in SARS-CoV-2 Pathogenesis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34187614&form=6&db=m Thirty-day suicidal thoughts and behaviours in the Spanish adult general population during the first wave of the Spain COVID-19 pandemic. unassigned - 2.4.2.30 Cowpox http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8999887&form=6&db=m Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis. unassigned - 2.4.2.30 Cowpox http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9593265&form=6&db=m IL-3 withdrawal activates a CrmA-insensitive poly(ADP-ribose) polymerase cleavage enzyme in factor-dependent myeloid progenitor cells. therapeutic application,unassigned 2,0 2.4.2.30 Craniocerebral Trauma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12628304&form=6&db=m Development of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Craniocerebral Trauma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12854754&form=6&db=m Poly(adenosine diphosphate-ribose) polymerase expression in human traumatic brain injury. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Craniocerebral Trauma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20480019&form=6&db=m A novel PARP inhibitor L-2286 in a rat model of impact acceleration head injury: An immunohistochemical and behavioral study. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7586746&form=6&db=m Distinct production of autoantibodies to nuclear components in ulcerative colitis and in Crohn's disease. diagnostic usage,unassigned 2,0 2.4.2.30 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30299179&form=6&db=m Role of microRNA-223 in the regulation of poly(ADP-ribose) polymerase in pediatric patients with Crohn's disease. causal interaction,unassigned 3,0 2.4.2.30 Cryptorchidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10871642&form=6&db=m Heat stress reduces poly(ADPR)polymerase expression in rat testis. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Cryptorchidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21547351&form=6&db=m Over expression of LDOC1 and PARP1, two pro-apoptotic genes, in a patient with cryptorchidism and DiGeorge anomaly. unassigned - 2.4.2.30 Cystadenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24874429&form=6&db=m Rapamycin-resistant PARP1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis (LAM). causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Cystadenoma, Serous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17413981&form=6&db=m Poly(adenosine diphosphate-ribose) polymerase expression in serous ovarian carcinoma: correlation with p53, MIB-1, and outcome. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2988945&form=6&db=m Role of exoenzyme S in chronic Pseudomonas aeruginosa lung infections. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7900823&form=6&db=m The role of protein kinase C in alpha-adrenergic regulation of NaCl(K) cotransport in human airway epithelial cells. causal interaction,unassigned 2,0 2.4.2.30 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8617745&form=6&db=m G-protein regulation of outwardly rectified epithelial chloride channels incorporated into planar bilayer membranes. therapeutic application,unassigned 1,0 2.4.2.30 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10899895&form=6&db=m Pseudomonas aeruginosa exoenzyme S induces transcriptional expression of proinflammatory cytokines and chemokines. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11807706&form=6&db=m Children with cystic fibrosis produce an immune response against exoenzyme S, a type III cytotoxin of Pseudomonas aeruginosa. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11867683&form=6&db=m Distinct fates of monocytes and T cells directly activated by Pseudomonas aeruginosa exoenzyme S. unassigned - 2.4.2.30 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34382902&form=6&db=m TRIM44 links the UPS to SQSTM1/p62-dependent aggrephagy and removing misfolded proteins. unassigned - 2.4.2.30 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17225077&form=6&db=m Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation. unassigned - 2.4.2.30 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19015854&form=6&db=m Protein nitration, PARP activation and NAD+ depletion may play a critical role in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis in the rat. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1319521&form=6&db=m In vitro formation and expansion of cysts derived from human renal cortex epithelial cells. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25474361&form=6&db=m Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 cytidine deaminase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26181065&form=6&db=m Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 cytidine deaminase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28463527&form=6&db=m Cytidine deaminase deficiency impairs sister chromatid disjunction by decreasing PARP-1 activity. causal interaction,unassigned 2,0 2.4.2.30 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30098088&form=6&db=m Physiological, biochemical and molecular responses to water stress and rehydration in Mediterranean adapted tomato landraces. causal interaction,unassigned 2,0 2.4.2.30 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30478677&form=6&db=m Effects of long-term dehydration on oxidative stress, apoptotic markers and neuropeptides in the gastric mucosa of the dromedary camel. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32932715&form=6&db=m Photo-Protective Mechanisms and the Role of Poly (ADP-Ribose) Polymerase Activity in a Facultative CAM Plant Exposed to Long-Term Water Deprivation. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12633148&form=6&db=m Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10610182&form=6&db=m A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11104510&form=6&db=m P0 protein peptide 180-199 together with pertussis toxin induces experimental autoimmune neuritis in resistant C57BL/6 mice. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14657223&form=6&db=m Activation of microglial poly(ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a link between demyelination and neuronal damage. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16184194&form=6&db=m IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis. unassigned - 2.4.2.30 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18339308&form=6&db=m A new EAE model of brain demyelination induced by intracerebroventricular pertussis toxin. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20157013&form=6&db=m Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21343230&form=6&db=m PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22431411&form=6&db=m PARP-1 deletion promotes subventricular zone neural stem cells toward a glial fate. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32688029&form=6&db=m Chronic mechanical hypersensitivity in experimental autoimmune encephalomyelitis is regulated by disease severity and neuroinflammation. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32871475&form=6&db=m A new lipophilic amino alcohol, chemically similar to compound FTY720, attenuates the pathogenesis of experimental autoimmune encephalomyelitis by PI3K/Akt pathway inhibition. ongoing research,unassigned 3,0 2.4.2.30 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026317&form=6&db=m Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies. causal interaction,unassigned 3,0 2.4.2.30 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33332573&form=6&db=m High-content screening identifies inhibitors of oxidative stress-induced parthanatos: cytoprotective and anti-inflammatory effects of ciclopirox. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Dermatitis, Allergic Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12102657&form=6&db=m Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11442752&form=6&db=m Peroxynitrite production, DNA breakage, and poly(ADP-ribose) polymerase activation in a mouse model of oxazolone-induced contact hypersensitivity. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12102657&form=6&db=m Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16456531&form=6&db=m Engagement of CD47 inhibits the contact hypersensitivity response via the suppression of motility and B7 expression by Langerhans cells. therapeutic application,unassigned 4,0 2.4.2.30 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18633442&form=6&db=m Poly(ADP-ribose) polymerase mediates inflammation in a mouse model of contact hypersensitivity. causal interaction,ongoing research,unassigned 3,1,0 2.4.2.30 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20613774&form=6&db=m Genetic ablation of PARP-1 protects against oxazolone-induced contact hypersensitivity by modulating oxidative stress. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Dermatitis, Phototoxic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27427773&form=6&db=m The PARP inhibitor PJ-34 sensitizes cells to UVA-induced phototoxicity by a PARP independent mechanism. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Dermatitis, Phototoxic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31962157&form=6&db=m Crosstalk between oxidative stress-induced apoptotic and autophagic signaling pathways in Zn(II) phthalocyanine photodynamic therapy of melanoma. unassigned - 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824290&form=6&db=m Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14523035&form=6&db=m Diabetes, microvascular complications, and cardiovascular complications: what is it about glucose? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15616034&form=6&db=m Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications. unassigned - 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15723618&form=6&db=m Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911334&form=6&db=m Roles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15962096&form=6&db=m The pathogenesis of diabetic complications: the role of DNA injury and poly(ADP-ribose) polymerase activation in peroxynitrite-mediated cytotoxicity. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16306359&form=6&db=m Oxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase (PARP) Activation in Experimental Diabetic Neuropathy: The Relation Is Revisited. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16356118&form=6&db=m Increased sorbitol pathway activity generates oxidative stress in tissue sites for diabetic complications. causal interaction,unassigned 3,0 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16356120&form=6&db=m Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16731831&form=6&db=m Poly(ADP-Ribose) Polymerase Inhibition Alleviates Experimental Diabetic Sensory Neuropathy. causal interaction,unassigned 4,0 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17337195&form=6&db=m Does diabetes mellitus target motor neurons? causal interaction,unassigned 4,0 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17397824&form=6&db=m Poly(ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro. causal interaction,unassigned 4,0 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17976390&form=6&db=m PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18351623&form=6&db=m PARP activation and the alteration of vasoactive factors and extracellular matrix protein in retina and kidney in diabetes. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18516100&form=6&db=m Oxidative stress-induced, poly(ADP-ribose) polymerase-dependent upregulation of ET-1 expression in chronic diabetic complications. ongoing research,unassigned 4,0 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18657544&form=6&db=m PARP mediates structural alterations in diabetic cardiomyopathy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21496888&form=6&db=m Poly(ADP-ribose) polymerase is involved in the development of diabetic cystopathy via regulation of nuclear factor kappa B. therapeutic application,unassigned 1,0 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21617845&form=6&db=m Poly(ADP-ribose)polymerase inhibition counteracts renal hypertrophy and multiple manifestations of peripheral neuropathy in diabetic Akita mice. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22923475&form=6&db=m Marrow-Derived Cells Regulate the Development of Early Diabetic Retinopathy and Tactile Allodynia in Mice. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.4.2.30 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28224182&form=6&db=m PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Diabetes Insipidus, Nephrogenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3941589&form=6&db=m Effect of pertussis toxin on water metabolism in the rat. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12677203&form=6&db=m PARP as a Drug Target for the Therapy of Diabetic Cardiovascular Dysfunction. causal interaction,unassigned 4,0 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15054118&form=6&db=m Poly(ADP-ribose) polymerase contributes to the development of myocardial infarction in diabetic rats and regulates the nuclear translocation of apoptosis-inducing factor. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911334&form=6&db=m Roles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15953818&form=6&db=m Poly(ADP-ribose) polymerase: the nuclear target in signal transduction and its role in brain ischemia-reperfusion injury. causal interaction,unassigned 4,0 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16982071&form=6&db=m Diabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase. ongoing research,unassigned 3,0 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17520094&form=6&db=m Poly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19263033&form=6&db=m Rapid 'glycaemic swings' induce nitrosative stress, activate poly(ADP-ribose) polymerase and impair endothelial function in a rat model of diabetes mellitus. ongoing research,unassigned 2,0 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19597800&form=6&db=m Nitrative stress and poly(ADP-ribose) polymerase activation in healthy and gestational diabetic pregnancies. causal interaction,unassigned 4,0 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21697640&form=6&db=m Adenosine thiamine triphosphate (AThTP) inhibits poly(ADP-ribose) polymerase-1 (PARP-1) activity. causal interaction,unassigned 1,0 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21870266&form=6&db=m Quantification of PARP Activity in Human Tissues: Ex Vivo Assays in Blood Cells and Immunohistochemistry in Human Biopsies. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22454481&form=6&db=m Poly(ADP-ribose) polymerase 1 inhibition improves coronary arteriole function in type 2 diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22555049&form=6&db=m Tempol reduces podocyte apoptosis via PARP signaling pathway in experimental diabetes mellitus. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23040216&form=6&db=m Relationship between NADPH oxidase p22phox C242T, PARP-1 Val762Ala polymorphisms, angiographically verified coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus. causal interaction,diagnostic usage,unassigned 3,1,0 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25411384&form=6&db=m Theobromine increases NAD?/Sirt-1 activity and protects the kidney under diabetic conditions. causal interaction,unassigned 3,0 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27687054&form=6&db=m Effects of Trans-Resveratrol on hyperglycemia-induced abnormal spermatogenesis, DNA damage and alterations in poly (ADP-ribose) polymerase signaling in rat testis. ongoing research,unassigned 4,0 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28695500&form=6&db=m Quantification of PARP Activity in Human Tissues: Ex Vivo Assays in Blood Cells and Immunohistochemistry in Human Biopsies. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29238179&form=6&db=m Role of poly (ADP-ribose) polymerase-1 and cytokines in acute renal injury in elderly Chinese patients with diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32757651&form=6&db=m Poly(ADP-Ribose) Polymerase Activity and Coronary Artery Disease in Type 2 Diabetes Mellitus: An Observational and Bidirectional Mendelian Randomization Study. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34020532&form=6&db=m The parp-1 and bax genes as potential targets for treatment of the heart functioning impairments induced by type 1 diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.4.2.30 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34364219&form=6&db=m PARP1 deficiency protects against hyperglycemia-induced neointimal hyperplasia by upregulating TFPI2 activity in diabetic mice. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Diabetes Mellitus, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22555049&form=6&db=m Tempol reduces podocyte apoptosis via PARP signaling pathway in experimental diabetes mellitus. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9498636&form=6&db=m Enhanced G protein activation in IDDM patients with diabetic nephropathy. causal interaction,unassigned 3,0 2.4.2.30 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10086388&form=6&db=m Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11591122&form=6&db=m A dinucleotide repeat polymorphism at the poly(ADP-ribose) polymerase gene is not associated with predisposition to type 1 diabetes in French Caucasians. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 2.4.2.30 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11978644&form=6&db=m Unexpected sensitivity of nonobese diabetic mice with a disrupted poly(ADP-Ribose) polymerase-1 gene to streptozotocin-induced and spontaneous diabetes. ongoing research,unassigned 4,0 2.4.2.30 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12829633&form=6&db=m Poly (ADP-ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16982071&form=6&db=m Diabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase. ongoing research,unassigned 3,0 2.4.2.30 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17644085&form=6&db=m A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice. causal interaction,unassigned 4,0 2.4.2.30 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19854869&form=6&db=m Poly(Adenosine 5'-Diphosphate-Ribose) Polymerase Inhibition Counteracts Multiple Manifestations of Experimental Type 1 Diabetic Nephropathy. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19945439&form=6&db=m Poly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20188823&form=6&db=m Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27687054&form=6&db=m Effects of Trans-Resveratrol on hyperglycemia-induced abnormal spermatogenesis, DNA damage and alterations in poly (ADP-ribose) polymerase signaling in rat testis. ongoing research,unassigned 4,0 2.4.2.30 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34020532&form=6&db=m The parp-1 and bax genes as potential targets for treatment of the heart functioning impairments induced by type 1 diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.4.2.30 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12438293&form=6&db=m Poly(ADP-Ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity. causal interaction,diagnostic usage,unassigned 3,2,0 2.4.2.30 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15777748&form=6&db=m The role of impaired insulin/IGF action in primary diabetic encephalopathy. ongoing research,unassigned 3,0 2.4.2.30 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15895395&form=6&db=m Poly(ADP-ribose)polymerase activity is reduced in circulating mononuclear cells from type 2 diabetic patients. causal interaction,ongoing research,unassigned 4,3,0 2.4.2.30 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17065336&form=6&db=m Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19321592&form=6&db=m Poly (ADP-ribose) polymerase-1-inhibiting flavonoids attenuate cytokine release in blood from male patients with chronic obstructive pulmonary disease or type 2 diabetes. causal interaction,unassigned 4,0 2.4.2.30 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22454481&form=6&db=m Poly(ADP-ribose) polymerase 1 inhibition improves coronary arteriole function in type 2 diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.4.2.30 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23040216&form=6&db=m Relationship between NADPH oxidase p22phox C242T, PARP-1 Val762Ala polymorphisms, angiographically verified coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus. causal interaction,diagnostic usage,unassigned 3,1,0 2.4.2.30 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23349490&form=6&db=m Enhanced NF?B Activity Impairs Vascular Function through PARP-1, SP-1 and COX2-Dependent Mechanisms in Type 2 Diabetes. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27324704&form=6&db=m The relationship between obstructive sleep apnea and intra-epidermal nerve fiber density, PARP activation and foot ulceration in patients with type 2 diabetes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28224182&form=6&db=m PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32757651&form=6&db=m Poly(ADP-Ribose) Polymerase Activity and Coronary Artery Disease in Type 2 Diabetes Mellitus: An Observational and Bidirectional Mendelian Randomization Study. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.4.2.30 Diabetes, Gestational http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26568110&form=6&db=m [The severity of gestational diabetes mellitus affects microvascular dysfunction measured three years after pregnancy that may be related to increased oxidative stress]. causal interaction,unassigned 3,0 2.4.2.30 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391839&form=6&db=m Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16631532&form=6&db=m Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme. therapeutic application,unassigned 2,0 2.4.2.30 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18657544&form=6&db=m PARP mediates structural alterations in diabetic cardiomyopathy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19175688&form=6&db=m Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27027354&form=6&db=m Poly(ADP-ribose) polymerase 1 inhibition protects cardiomyocytes from inflammation and apoptosis in diabetic cardiomyopathy. causal interaction,diagnostic usage,unassigned 3,1,0 2.4.2.30 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30359575&form=6&db=m PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1? axis. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824290&form=6&db=m Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15723618&form=6&db=m Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026323&form=6&db=m Role for poly(ADP-ribose) polymerase activation in diabetic nephropathy, neuropathy and retinopathy. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17065336&form=6&db=m Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18693296&form=6&db=m Gallotannin ameliorates the development of streptozotocin-induced diabetic nephropathy by preventing the activation of PARP. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19945439&form=6&db=m Poly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20621183&form=6&db=m Poly(ADP-ribose) polymerase-1 (PARP-1) gene deficiency alleviates diabetic kidney disease. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28224182&form=6&db=m PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28767064&form=6&db=m Psoralea corylifolia L. Seed Extract Attenuates Diabetic Nephropathy by Inhibiting Renal Fibrosis and Apoptosis in Streptozotocin-Induced Diabetic Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33531822&form=6&db=m PARP-1 and SIRT-1 are Interacted in Diabetic Nephropathy by Activating AMPK/PGC-1? Signaling Pathway. causal interaction,unassigned 2,0 2.4.2.30 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34345272&form=6&db=m Saxagliptin protects against diabetic nephropathy by inhibiting caspase 3/PARP-1-dependent nephrocyte apoptosis. therapeutic application,unassigned 1,0 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14988256&form=6&db=m Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15298348&form=6&db=m Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15855340&form=6&db=m Low-dose poly(ADP-ribose) polymerase inhibitor-containing combination therapies reverse early peripheral diabetic neuropathy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16306359&form=6&db=m Oxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase (PARP) Activation in Experimental Diabetic Neuropathy: The Relation Is Revisited. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16644248&form=6&db=m Effects of poly(ADP-ribose) polymerase inhibition on dysfunction of non-adrenergic non-cholinergic neurotransmission in gastric fundus in diabetic rats. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16731831&form=6&db=m Poly(ADP-Ribose) Polymerase Inhibition Alleviates Experimental Diabetic Sensory Neuropathy. causal interaction,unassigned 4,0 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17976390&form=6&db=m PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18054108&form=6&db=m Leu54Phe and Val762Ala polymorphisms in the poly(ADP-ribose)polymerase-1 gene are associated with diabetic polyneuropathy in Russian type 1 diabetic patients. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18194675&form=6&db=m Poly(ADP-ribose) polymerase inhibition as a novel therapeutic approach against intraepidermal nerve fiber loss and neuropathic pain associated with advanced diabetic neuropathy: a commentary on "PARP Inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy". causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18262571&form=6&db=m Protective effects of 4-amino1,8-napthalimide, a poly (ADP-ribose) polymerase inhibitor in experimental diabetic neuropathy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19900402&form=6&db=m Concurrent targeting of nitrosative stress-PARP pathway corrects functional, behavioral and biochemical deficits in experimental diabetic neuropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20005237&form=6&db=m Functional and biochemical evidence indicating beneficial effect of Melatonin and Nicotinamide alone and in combination in experimental diabetic neuropathy. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20357221&form=6&db=m New Therapeutic and Biomarker Discovery for Peripheral Diabetic Neuropathy: PARP Inhibitor, Nitrotyrosine, and Tumor Necrosis Factor-{alpha} causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20795891&form=6&db=m Emerging drugs for diabetic neuropathy. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21978940&form=6&db=m Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion. diagnostic usage,unassigned 3,0 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22020669&form=6&db=m Treatment with Actovegin® Improves Sensory Nerve Function and Pathology in Streptozotocin-Diabetic Rats via Mechanisms Involving Inhibition of PARP Activation. therapeutic application,unassigned 1,0 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29966615&form=6&db=m Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets. causal interaction,unassigned 3,0 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32547134&form=6&db=m Lipoic Acid Decreases the Expression of Poly ADP-Ribose Polymerase and Inhibits Apoptosis in Diabetic Rats. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33186087&form=6&db=m Biomarkers in diabetic neuropathy. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15202016&form=6&db=m Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15504977&form=6&db=m Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18351623&form=6&db=m PARP activation and the alteration of vasoactive factors and extracellular matrix protein in retina and kidney in diabetes. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19273327&form=6&db=m Role of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy. ongoing research,unassigned 2,0 2.4.2.30 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20939801&form=6&db=m Aldose Reductase / Polyol Inhibitors For Diabetic Retinopathy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23652053&form=6&db=m Effect of the regimen of Gaoshan Hongjingtian on the mechanism of poly (ADP-ribose) polymerase regulation of nuclear factor kappa B in the experimental diabetic retinopathy. ongoing research,unassigned 3,0 2.4.2.30 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28438542&form=6&db=m Identification of low micromolar dual inhibitors for aldose reductase (ALR2) and poly (ADP-ribose) polymerase (PARP-1) using structure based design approach. therapeutic application,unassigned 4,0 2.4.2.30 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28478229&form=6&db=m Role of PARP-1 as a novel transcriptional regulator of MMP-9 in diabetic retinopathy. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29912609&form=6&db=m The Poly(ADP-Ribose)Polymerase-1 Inhibitor 1,5-Isoquinolinediol Attenuate Diabetes-Induced NADPH Oxidase-Derived Oxidative Stress in Retina. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Diffuse Intrinsic Pontine Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32229503&form=6&db=m Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 DiGeorge Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21547351&form=6&db=m Over expression of LDOC1 and PARP1, two pro-apoptotic genes, in a patient with cryptorchidism and DiGeorge anomaly. unassigned - 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=210453&form=6&db=m Pseudomonas aeruginosa exoenzyme S: an adenosine diphosphate ribosyltransferase distinct from toxin A. unassigned - 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1346876&form=6&db=m Immunogenicity of combined diphtheria, tetanus, and pertussis vaccine given at 2, 3, and 4 months versus 3, 5, and 9 months of age. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1452339&form=6&db=m Construction of a diphtheria toxin A fragment-C180 peptide fusion protein which elicits a neutralizing antibody response against diphtheria toxin and pertussis toxin. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1621656&form=6&db=m Clinical reactions and immunogenicity of the BIKEN acellular diphtheria and tetanus toxoids and pertussis vaccine in 4- through 6-year-old US children. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1681018&form=6&db=m Immunogenicity of primary DPT vaccination. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,3,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1778305&form=6&db=m Protective immunogenicity of synthetic peptides selected from the amino acid sequence of Bordetella pertussis toxin subunit S1. unassigned - 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1855015&form=6&db=m Persistence of antibody after accelerated immunisation with diphtheria/tetanus/pertussis vaccine. therapeutic application,unassigned 1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1901617&form=6&db=m Computer modelling of the NAD binding site of ADP-ribosylating toxins: active-site structure and mechanism of NAD binding. therapeutic application,unassigned 2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2304902&form=6&db=m Protective immunogenicity of two synthetic peptides selected from the amino acid sequence of Bordetella pertussis toxin subunit S1. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2470088&form=6&db=m Identification of amino acid residues essential for the enzymatic activities of pertussis toxin. therapeutic application,unassigned 2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2670900&form=6&db=m Cloning, nucleotide sequence, and hybridization studies of the type IIb heat-labile enterotoxin gene of Escherichia coli. causal interaction,unassigned 4,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3736664&form=6&db=m Botulinum C2 toxin ADP-ribosylates actin. unassigned - 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6271678&form=6&db=m Production of exoenzyme S by clinical isolates of Pseudomonas aeruginosa. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7489748&form=6&db=m Pertussis toxin-sensitive GTP-binding proteins regulate activation-induced apoptotic cell death of human natural killer cells. therapeutic application,unassigned 1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7521636&form=6&db=m A randomized controlled trial of two acellular pertussis-diphtheria-tetanus vaccines in primary immunization in Ghana: antibody responses and adverse reactions. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7636648&form=6&db=m Effect of priming with diphtheria and tetanus toxoids combined with whole-cell pertussis vaccine or with acellular pertussis vaccine on the safety and immunogenicity of a booster dose of an acellular pertussis vaccine containing a genetically inactivated pertussis toxin in fifteen- to twenty-one-month-old children. Italian Multicenter Group for the Study of Recombinant Acellular Pertussis Vaccine. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7659475&form=6&db=m Comparison of 13 acellular pertussis vaccines: overview and serologic response. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7822277&form=6&db=m Conservation of a common motif in enzymes catalyzing ADP-ribose transfer. Identification of domains in mammalian transferases. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7830559&form=6&db=m Common features of the NAD-binding and catalytic site of ADP-ribosylating toxins. unassigned - 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8201477&form=6&db=m Comparative study of a whole-cell pertussis vaccine and a recombinant acellular pertussis vaccine. The Italian Multicenter Group for the Study of Recombinant Acellular Pertussis Vaccine. diagnostic usage,therapeutic application,unassigned 4,2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8406812&form=6&db=m Pertussis toxin-induced alterations of murine hepatic drug metabolism following administration of diphtheria and tetanus toxoids and pertussis vaccine adsorbed. diagnostic usage,therapeutic application,unassigned 2,2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8438810&form=6&db=m Comparison of the safety and immunogenicity of acellular (BIKEN) and whole-cell pertussis vaccines in 15- to 20-month-old children. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8458345&form=6&db=m A chimeric toxin to study the role of the 21 kDa GTP binding protein rho in the control of actin microfilament assembly. diagnostic usage,unassigned 3,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8522378&form=6&db=m Serum antibodies to the components of diphtheria-tetanus-pertussis vaccine in Polish children related to vaccination status. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8533580&form=6&db=m Immunogenicity and reactogenicity of the component acellular pertussis vaccine produced by a combination of column purified pertussis toxin and filamentous haemagglutinin. unassigned - 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8678289&form=6&db=m Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase. therapeutic application,unassigned 1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8692916&form=6&db=m Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation. ongoing research,unassigned 2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9031875&form=6&db=m Comparative safety and immunogenicity of an acellular versus whole-cell pertussis component of diphtheria-tetanus-pertussis vaccines in Senegalese infants. unassigned - 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9193642&form=6&db=m Sequence and structural links between distant ADP-ribosyltransferase families. unassigned - 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9211321&form=6&db=m Use of biotinylated NAD to label and purify ADP-ribosylated proteins. therapeutic application,unassigned 1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9272340&form=6&db=m Adverse reactions of a pertussis toxoid vaccine in a double-blind placebo-controlled trial. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9427051&form=6&db=m Serum antibodies to diphtheria-tetanus-pertussis vaccine components in Argentine children. diagnostic usage,therapeutic application,unassigned 4,3,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9427455&form=6&db=m Safety and immunogenicity of a combined pentavalent diphtheria, tetanus, acellular pertussis, inactivated poliovirus and Haemophilus influenzae type b-tetanus conjugate vaccine in infants, compared with a whole cell pertussis pentavalent vaccine. causal interaction,unassigned 2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9569476&form=6&db=m Effect of combination with an acellular pertussis, diphtheria, tetanus vaccine on antibody response to Hib vaccine (PRP-T). therapeutic application,unassigned 1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9725917&form=6&db=m Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function. unassigned - 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9855426&form=6&db=m Standardization of acellular pertussis vaccine by assay of serum neutralizing antibodies to pertussis toxin (antitoxin): analogy with diphtheria toxoid. diagnostic usage,unassigned 2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10206134&form=6&db=m Adverse effects and sero-responses to an acellular pertussis/diphtheria/tetanus vaccine when combined with Haemophilus influenzae type b vaccine in an accelerated schedule. diagnostic usage,ongoing research,unassigned 4,2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10493334&form=6&db=m Safety and immunogenicity of heptavalent pneumococcal CRM197 conjugate vaccine in infants and toddlers. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,2 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10493336&form=6&db=m Comparison of a fifth dose of a five-component acellular or a whole cell pertussis vaccine in children four to six years of age. therapeutic application,unassigned 1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10580209&form=6&db=m Immunogenicity study of a combined diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis vaccine used to reconstitute a freeze-dried Haemophilus influenzae type b vaccine (DTaP-IPV//PRP-T) administered simultaneously with a hepatitis B vaccine at two, three and four months of life. diagnostic usage,therapeutic application,unassigned 2,2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10592076&form=6&db=m Local reactions and IgE antibodies to pertussis toxin after acellular diphtheria-tetanus-pertussis immunization. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600208&form=6&db=m Evaluation of a guinea pig model to assess interference in the immunogenicity of different components of a combination vaccine comprising diphtheria, tetanus and acellular pertussis (DTaP) vaccine and haemophilus influenzae type b capsular polysaccharide conjugate vaccine. therapeutic application,unassigned 1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10617748&form=6&db=m Safety and immunogenicity of six acellular pertussis vaccines and one whole-cell pertussis vaccine given as a fifth dose in four- to six-year-old children. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10617749&form=6&db=m Extensive swelling after booster doses of acellular pertussis-tetanus-diphtheria vaccines. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10624095&form=6&db=m [Induction of protective immunity for Bordetella pertussis by nasal inoculation of pertussis vaccine in mice] ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10667206&form=6&db=m Bacterial toxins inhibiting or activating small GTP-binding proteins. unassigned - 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10910608&form=6&db=m Effect of local massage on vaccination: DTP and DTPa. therapeutic application,unassigned 2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11312009&form=6&db=m Immunogenicity and reactogenicity of a single dose of a diphtheria--tetanus--acellular pertussis component vaccine (DTaP) compared to a diphtheria--tetanus toxoid (Td) and a diphtheria toxoid vaccine (d) in adults. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,2 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11520252&form=6&db=m Antibody responses of healthy infants to concurrent administration of a bivalent haemophilus influenzae type b-hepatitis B vaccine with diphtheria-tetanus-pertussis, polio and measles-mumps-rubella vaccines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11642633&form=6&db=m Safety and immunogenicity of Biken acellular pertussis vaccine in combination with diphtheria and tetanus toxoid as a fifth dose at four to six years of age. Munich Vaccine Study Group. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12403070&form=6&db=m On technological and immunological benefits of multivalent single-injection microsphere vaccines. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14532091&form=6&db=m Identification of peptides that mimic the pertussis toxin binding site on bovine fetuin. causal interaction,unassigned 3,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14711858&form=6&db=m Acellular pertussis vaccine given by accelerated schedule: response of preterm infants. diagnostic usage,unassigned 1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15060220&form=6&db=m Antibody response to diphtheria-tetanus-pertussis immunization in preterm infants who receive dexamethasone for chronic lung disease. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15125661&form=6&db=m Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15458385&form=6&db=m Structure-function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa. unassigned - 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15593007&form=6&db=m The diphtheria and pertussis components of diphtheria-tetanus toxoids-pertussis vaccine should be genetically inactivated mutant toxins. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16249929&form=6&db=m Diphtheria, tetanus and pertussis antibodies in 10-year-old children before and after a booster dose of three toxoids: implications for the timing of a booster dose. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16371866&form=6&db=m A modified vaccine reduces the rate of large injection site reactions to the preschool booster dose of diphtheria-tetanus-acellular pertussis vaccine: results of a randomized, controlled trial. diagnostic usage,unassigned 1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16410887&form=6&db=m Immunogenicity of a combined DTPa-HB vaccine co-administered with Haemophilus influenzae type B conjugate vaccine (PRP-T) for primary and booster vaccinations. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16950635&form=6&db=m Expression and purification of a trivalent pertussis toxin-diphtheria toxin-tetanus toxin fusion protein in Escherichia coli. unassigned - 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17447474&form=6&db=m [The risk of pertussis and diphtheria infections among pediatric healthcare workers in Japan] causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17915215&form=6&db=m Phosphorylation, desensitization and internalization of human alpha1B-adrenoceptors induced by insulin-like growth factor-I. therapeutic application,unassigned 2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18321880&form=6&db=m Measuring immunoglobulin g antibodies to tetanus toxin, diphtheria toxin, and pertussis toxin with single-antigen enzyme-linked immunosorbent assays and a bead-based multiplex assay. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18407287&form=6&db=m Development and validation of a multiplex immunoassay for the simultaneous determination of serum antibodies to Bordetella pertussis, diphtheria and tetanus. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18534242&form=6&db=m Poor immune responses to a birth dose of diphtheria, tetanus, and acellular pertussis vaccine. diagnostic usage,unassigned 4,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19464556&form=6&db=m Generation of plant-derived recombinant DTP subunit vaccine. ongoing research,unassigned 2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19480581&form=6&db=m Seroprevalence and placental transportation of maternal antibodies specific for Neisseria meningitidis serogroup C, Haemophilus influenzae type B, diphtheria, tetanus, and pertussis. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20864810&form=6&db=m Humoral immunity of dTap-IPV vaccine (REPEVAX(®)) administered one month after dT-IPV vaccine (REVAXIS(®)) in adults with unknown vaccination history. therapeutic application,unassigned 2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21043546&form=6&db=m Tdap(5) vaccine (covaxis®): a review of its use as a single-booster immunization for the prevention of tetanus, diphtheria, and pertussis in children (aged ?4 years), adolescents, and adults. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21325488&form=6&db=m Fast, antigen-saving multiplex immunoassay to determine levels and avidity of mouse serum antibodies to pertussis, diphtheria, and tetanus antigens. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21351814&form=6&db=m Spotlight on Tdap? vaccine (Covaxis®) as a single-booster immunization for the prevention of tetanus, diphtheria, and pertussis: in children (aged ?4 years), adolescents, and adults. therapeutic application,unassigned 1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21864569&form=6&db=m Seroprevalence of antibodies to pertussis and diphtheria among healthy adults in China. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22754560&form=6&db=m mADP-RTs: versatile virulence factors from bacterial pathogens of plants and mammals. unassigned - 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22863658&form=6&db=m A fully liquid DTaP-IPV-Hep B-PRP-T hexavalent vaccine for primary and booster vaccination of healthy Mexican children. therapeutic application,unassigned 1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23357755&form=6&db=m PARP-1 and gene regulation: Progress and puzzles. causal interaction,unassigned 2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23601167&form=6&db=m PARP inhibitors: polypharmacology versus selective inhibition. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23994021&form=6&db=m Experience with monocomponent acellular pertussis combination vaccines for infants, children, adolescents and adults-A review of safety, immunogenicity, efficacy and effectiveness studies and 15 years of field experience. diagnostic usage,therapeutic application,unassigned 2,4,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24108779&form=6&db=m Immunogenicity and safety after booster vaccination of diphtheria, tetanus, and acellular pertussis in young adults: an open randomized controlled trial in Japan. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24188023&form=6&db=m Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3. therapeutic application,unassigned 3,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25023120&form=6&db=m Novel bacterial ADP-ribosylating toxins: structure and function. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25432510&form=6&db=m Vaccines, emerging viruses, and how to avoid disaster. therapeutic application,unassigned 2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25510388&form=6&db=m Interchangeability of meningococcal group C conjugate vaccines with different carrier proteins in the United Kingdom infant immunisation schedule. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25635049&form=6&db=m Structural Basis for Lack of ADP-Ribosyltransferase Activity in Poly(ADP-Ribose) Polymerase-13/Zinc Finger Antiviral Protein. unassigned - 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26177302&form=6&db=m Seroepidemiology of diphtheria and pertussis in Beijing, China: A cross-sectional study. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26529073&form=6&db=m Pertussis vaccination during pregnancy in Vietnam: Results of a randomized controlled trial Pertussis vaccination during pregnancy. diagnostic usage,therapeutic application,unassigned 1,2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26592142&form=6&db=m Pertussis vaccination during pregnancy in Belgium: Results of a prospective controlled cohort study. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27142328&form=6&db=m Pertussis vaccination during pregnancy in Belgium: Follow-up of infants until 1 month after the fourth infant pertussis vaccination at 15 months of age. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27171114&form=6&db=m A Belgian Serosurveillance/Seroprevalence Study of Diphtheria, Tetanus and Pertussis Using a Luminex xMAP Technology-Based Pentaplex. therapeutic application,unassigned 2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27838673&form=6&db=m The Effect of Maternal Pertussis Immunization on Infant Vaccine Responses to a Booster Pertussis-Containing Vaccine in Vietnam. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28011915&form=6&db=m Genome-Wide Association Mapping of the Antibody Response to Diphtheria, Tetanus and Acellular Pertussis Vaccine in Mice. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28233625&form=6&db=m Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28277900&form=6&db=m Influence of maternal vaccination against diphtheria, tetanus, and pertussis on the avidity of infant antibody responses to a pertussis containing vaccine in Belgium. diagnostic usage,therapeutic application,unassigned 1,3,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29408190&form=6&db=m Seroepidemiology of diphtheria and pertussis in Chongqing, China: serology-based evidence of Bordetella pertussis infection. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087050&form=6&db=m Immune response to a Tdap booster in vertically HIV-infected adolescents. diagnostic usage,unassigned 4,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30097860&form=6&db=m Assessment of Intracellular Auto-Modification Levels of ARTD10 Using Mono-ADP-Ribose-Specific Macrodomains 2 and 3 of Murine Artd8. unassigned - 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30136189&form=6&db=m Optimization of rPDT fusion protein expression by Escherichia coli in pilot scale fermentation: a statistical experimental design approach. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30208475&form=6&db=m Immunogenicity and Safety of Monovalent Acellular Pertussis Vaccine at Birth: A Randomized Clinical Trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,2 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30212033&form=6&db=m [Seroepidemiological Studies on Pertussis, Diphtheria and Tetanus among Nursing Students Enrolled between 1994 and 2011 in the Kitakyushu District]. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30219367&form=6&db=m Reactogenicity and immunogenicity of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant and nonpregnant women. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30690077&form=6&db=m Development and Validation of Magnetic Bead Pentaplex Immunoassay for Simultaneous Quantification of murine serum IgG antibodies to Acellular Pertussis, Diphtheria and Tetanus Antigens used in combination vaccines. therapeutic application,unassigned 1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30758857&form=6&db=m Antibody responses to Bordetella pertussis and other childhood vaccines in infants born to mothers who received pertussis vaccine in pregnancy- a prospective, observational cohort study from the UK. ongoing research,unassigned 2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30831450&form=6&db=m Quantitative determination of bioactive proteins in diphtheria tetanus acellular pertussis (DTaP) vaccine by liquid chromatography tandem mass spectrometry. diagnostic usage,unassigned 1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31547158&form=6&db=m Genetic Variation in the Magnitude and Longevity of the IgG Subclass Response to a Diphtheria-Tetanus-Acellular Pertussis (DTaP) Vaccine in Mice. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32053508&form=6&db=m Seroprevalence of antibodies for pertussis and diphtheria among people leaving or entering China: a cross-sectional study. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32387447&form=6&db=m Seroprevalence of antibodies against diphtheria, tetanus, and pertussis among healthy Thai adolescents. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32930758&form=6&db=m Association of Routine Infant Vaccinations With Antibody Levels Among Preterm Infants. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33059000&form=6&db=m The quantitative analysis of the mechanism involved in pertussis toxin-mediated cell clustering and its implications in the in vitro quality control of diphtheria tetanus and whole cell pertussis vaccines. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33176935&form=6&db=m Enhanced post-licensure safety surveillance of a new recombinant acellular pertussis vaccine licensed as a monovalent (aP, Pertagen®) and tetanus, reduced-dose diphtheria combination (TdaP, Boostagen®) vaccine for immunization of adolescents and adults in Thailand. therapeutic application,unassigned 3,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33197362&form=6&db=m Adequate tetanus but poor diphtheria and pertussis response to a Tdap booster in adolescents with juvenile systemic lupus erythematosus. diagnostic usage,unassigned 4,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33478788&form=6&db=m Tdap booster to adolescents with juvenile idiopathic arthritis on and off anti-TNF agents is safe and immunogenic. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33517831&form=6&db=m Decline of serologic immunity to diphtheria, tetanus and pertussis with age suggested a full life vaccination in mainland China. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33922595&form=6&db=m The PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33928900&form=6&db=m Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019. diagnostic usage,unassigned 2,0 2.4.2.30 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34386749&form=6&db=m Antibody persistence 2 and 3 years after booster vaccination of adolescents with recombinant acellular pertussis monovalent aPgen or combined TdaPgen vaccines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 DNA Repair-Deficiency Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24037533&form=6&db=m Predictive biomarkers for cancer therapy with PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 DNA Repair-Deficiency Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24057885&form=6&db=m Mitochondrial protein ATPase family, AAA domain containing 3A correlates with radioresistance in glioblastoma. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 DNA Repair-Deficiency Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25440059&form=6&db=m A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 DNA Repair-Deficiency Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26518896&form=6&db=m PARP inhibition: A promising therapeutic target in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 DNA Repair-Deficiency Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26873719&form=6&db=m Hereditary cancer syndromes: utilizing DNA repair deficiency as therapeutic target. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 DNA Repair-Deficiency Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29592880&form=6&db=m Trastuzumab resistant HER2+ breast cancer cells retain sensitivity to poly (ADP-ribose) polymerase (PARP) inhibition. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.4.2.30 DNA Repair-Deficiency Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30038706&form=6&db=m Inhibition of mTOR downregulates expression of DNA repair proteins and is highly efficient against BRCA2-mutated breast cancer in combination to PARP inhibition. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 DNA Repair-Deficiency Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30867218&form=6&db=m Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 DNA Repair-Deficiency Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31126889&form=6&db=m The BET inhibitor JQ1 attenuates double-strand break repair and sensitizes models of pancreatic ductal adenocarcinoma to PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 DNA Repair-Deficiency Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31310591&form=6&db=m Supraphysiological androgens suppress prostate cancer growth through androgen receptor-mediated DNA damage. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 DNA Repair-Deficiency Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32471999&form=6&db=m Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 DNA Repair-Deficiency Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32679669&form=6&db=m The Landscape and Therapeutic Implications of Molecular Profiles in Epithelial Ovarian Cancer. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 DNA Repair-Deficiency Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33150793&form=6&db=m Combinatorial Therapy of High Dose Vitamin C and PARP Inhibitors in DNA Repair Deficiency: A Series of 8 Patients. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 DNA Repair-Deficiency Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34423229&form=6&db=m Utility of Homologous Recombination Deficiency Biomarkers Across Cancer Types. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.4.2.30 dna-3-methyladenine glycosylase ii deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32042007&form=6&db=m Alkyladenine DNA glycosylase deficiency uncouples alkylation-induced strand break generation from PARP-1 activation and glycolysis inhibition. causal interaction,unassigned 3,0 2.4.2.30 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9247624&form=6&db=m The role of poly(ADP-ribose)polymerase in the induction of sister chromatid exchanges and micronuclei by mitomycin C in Down's syndrome cells as compared to euploid cells. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22227934&form=6&db=m Differential expression of PARP1 mRNA in leucocytes of patients with down's syndrome. diagnostic usage,ongoing research,unassigned 4,2,0 2.4.2.30 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34327724&form=6&db=m Identification of different side effects between PARP inhibitors and their polypharmacological multi-target rationale. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Dyslexia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18445785&form=6&db=m The complex of TFII-I, PARP1, and SFPQ proteins regulates the DYX1C1 gene implicated in neuronal migration and dyslexia. unassigned - 2.4.2.30 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19823587&form=6&db=m Protective effects of PARP-1 knockout on dyslipidemia-induced autonomic and vascular dysfunction in ApoE mice: effects on eNOS and oxidative stress. causal interaction,unassigned 3,0 2.4.2.30 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31683401&form=6&db=m [Gender-specific factors of ischemic stroke among atrial fibrillation patients]. unassigned - 2.4.2.30 Ectropion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30186159&form=6&db=m The Curcumin Analogs 2-Pyridyl Cyclohexanone Induce Apoptosis via Inhibition of the JAK2-STAT3 Pathway in Human Esophageal Squamous Cell Carcinoma Cells. therapeutic application,unassigned 1,0 2.4.2.30 Ehrlichiosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10772341&form=6&db=m Specific processing of poly(ADP-ribose) polymerase, accompanied by activation of caspase-3 and elevation/reduction of ceramide/hydrogen peroxide levels, during induction of apoptosis in host HL-60 cells infected by the human granulocytic ehrlichiosis (HGE) agent. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11089573&form=6&db=m Damage and repair of DNA in HIV encephalitis. diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17082642&form=6&db=m Metalloproteinases control brain inflammation induced by pertussis toxin in mice overexpressing the chemokine CCL2 in the central nervous system. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17084037&form=6&db=m The role of poly(ADP-ribose) polymerase-1 in CNS disease. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19849845&form=6&db=m Estrogen treatment following severe burn injury reduces brain inflammation and apoptotic signaling. causal interaction,unassigned 3,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8095458&form=6&db=m Protection against autoimmune disease by bacterial agents. II. PPD and pertussis toxin as proteins active in protecting mice against experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8640862&form=6&db=m Native, but not genetically inactivated, pertussis toxin protects mice against experimental allergic encephalomyelitis. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8898962&form=6&db=m Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse V beta gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor V beta b and T cell receptor V beta a H-2b mice. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9069580&form=6&db=m Immunomodulation of murine experimental autoimmune encephalomyelitis by pertussis toxin: the protective activity, but not the disease-enhancing activity, can be attributed to the nontoxic B-oligomer. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10683510&form=6&db=m Analysis of experimental autoimmune encephalomyelitis induced in F344 rats by pertussis toxin administration. causal interaction,ongoing research,unassigned 2,2,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10866127&form=6&db=m Differential roles of Fas ligand in spontaneous and actively induced autoimmune encephalomyelitis. unassigned - 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11313421&form=6&db=m Rapid depletion of peripheral antigen-specific T cells in TCR-transgenic mice after oral administration of myelin basic protein. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11418656&form=6&db=m Pertussis toxin inhibits induction of tissue-specific autoimmune disease by disrupting G protein-coupled signals. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11445281&form=6&db=m Pertussis toxin-induced hyperacute autoimmune encephalomyelitis in Lewis rats is correlated with increased expression of inducible nitric oxide synthase and tumor necrosis factor alpha. causal interaction,unassigned 4,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11585627&form=6&db=m Defective CD4T cell priming and resistance to experimental autoimmune encephalomyelitis in TNF-deficient mice due to innate immune hypo-responsiveness. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12077236&form=6&db=m Pertussis toxin modulates the immune response to neuroantigens injected in incomplete Freund's adjuvant: induction of Th1 cells and experimental autoimmune encephalomyelitis in the presence of high frequencies of Th2 cells. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12411406&form=6&db=m Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15236747&form=6&db=m Regulation of experimental autoimmune encephalomyelitis by CD4+, CD25+ and CD8+ T cells: analysis using depleting antibodies. therapeutic application,unassigned 2,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15557205&form=6&db=m TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease. diagnostic usage,therapeutic application,unassigned 2,3,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16849462&form=6&db=m Pertussis toxin reduces the number of splenic Foxp3+ regulatory T cells. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16893572&form=6&db=m Diversified serum IgG response involving non-myelin CNS proteins during experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16970675&form=6&db=m Experimental Autoimmune Encephalomyelitis Develops in CC Chemokine Receptor 7-deficient Mice with Altered T-cell Responses. ongoing research,unassigned 3,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16982873&form=6&db=m Induction of Autoimmunity by Expansion of Autoreactive CD4+CD62Llow Cells In Vivo. therapeutic application,unassigned 1,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19628872&form=6&db=m PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20398738&form=6&db=m Kinetics of IL-17- and interferon-gamma-producing PLPp-specific CD4 T cells in EAE induced by coinjection of PLPp/IFA with pertussis toxin in SJL mice. ongoing research,unassigned 1,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20700542&form=6&db=m Paradoxical effect of pertussis toxin on the delayed hypersensitivity response to autoantigens in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20811645&form=6&db=m Centrally administered pertussis toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an EAE mouse model. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21209857&form=6&db=m Repetitive pertussis toxin promotes development of regulatory T cells and prevents central nervous system autoimmune disease. causal interaction,unassigned 2,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21343230&form=6&db=m PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21418369&form=6&db=m Crawling phagocytes recruited in the brain vasculature after pertussis toxin exposure through IL6, ICAM1, and ITG?M. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22419424&form=6&db=m The regulatory effect of liuwei dihuang pills on cytokines in mice with experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23489378&form=6&db=m Beyond dna repair,the immunological role of parp-1 and its siblings. therapeutic application,unassigned 4,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23607899&form=6&db=m Poly(ADP-ribose) polymerase 2 contributes to neuroinflammation and neurological dysfunction in mouse experimental autoimmune encephalomyelitis. therapeutic application,unassigned 2,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23660634&form=6&db=m Pertussis toxin attenuates experimental autoimmune encephalomyelitis by upregulating neuronal vascular endothelial growth factor. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24444779&form=6&db=m Attenuation of the progression of adjuvant-induced arthritis by 3-aminobenzamide treatment. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24486709&form=6&db=m Pertussis toxin modulates microglia and T cell profile to protect experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24730062&form=6&db=m Long-term suppression of EAE relapses by pharmacological impairment of epitope spreading. therapeutic application,unassigned 4,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26616879&form=6&db=m Pertussis toxin promotes relapsing-remitting experimental autoimmune encephalomyelitis in Lewis rats. ongoing research,unassigned 2,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26724970&form=6&db=m The potential role of subclinical Bordetella Pertussis colonization in the etiology of multiple sclerosis. unassigned - 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26822306&form=6&db=m Immunomodulation By Subchronic Low Dose 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin. unassigned - 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28265351&form=6&db=m Elevated axonal membrane permeability and its correlation with motor deficits in an animal model of multiple sclerosis. ongoing research,unassigned 2,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29388727&form=6&db=m Special AT-rich sequence binding protein 1 is required for maintenance of T cell receptor responsiveness and development of experimental autoimmune encephalomyelitis. ongoing research,unassigned 1,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30001610&form=6&db=m Neuroprotective Effects of 6-Shogaol and Its Metabolite, 6-Paradol, in a Mouse Model of Multiple Sclerosis. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31454809&form=6&db=m Neuroinflammation and B-Cell Phenotypes in Cervical and Lumbosacral Regions of the Spinal Cord in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin. unassigned - 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31960801&form=6&db=m Protective effects of pharmacological therapies in animal models of multiple sclerosis: a review of studies 2014-2019. unassigned - 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33182064&form=6&db=m Amifostine ameliorates induction of experimental autoimmune encephalomyelitis: Effect on reactive oxygen species/NLRP3 pathway. ongoing research,unassigned 4,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33805762&form=6&db=m Pertussis Toxin Inhibits Encephalitogenic T-Cell Infiltration and Promotes a B-Cell-Driven Disease during Th17-EAE. therapeutic application,unassigned 4,0 2.4.2.30 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34310708&form=6&db=m Vascular and immunopathological role of Asymmetric Dimethylarginine (ADMA) in Experimental Autoimmune Encephalomyelitis. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7679952&form=6&db=m Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. therapeutic application,unassigned 4,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8095458&form=6&db=m Protection against autoimmune disease by bacterial agents. II. PPD and pertussis toxin as proteins active in protecting mice against experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8640862&form=6&db=m Native, but not genetically inactivated, pertussis toxin protects mice against experimental allergic encephalomyelitis. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8648142&form=6&db=m Inhibition by CTLA4Ig of experimental allergic encephalomyelitis. unassigned - 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8898962&form=6&db=m Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse V beta gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor V beta b and T cell receptor V beta a H-2b mice. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9069580&form=6&db=m Immunomodulation of murine experimental autoimmune encephalomyelitis by pertussis toxin: the protective activity, but not the disease-enhancing activity, can be attributed to the nontoxic B-oligomer. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10683510&form=6&db=m Analysis of experimental autoimmune encephalomyelitis induced in F344 rats by pertussis toxin administration. causal interaction,ongoing research,unassigned 2,2,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10706738&form=6&db=m Genetic analysis of the influence of pertussis toxin on experimental allergic encephalomyelitis susceptibility: an environmental agent can override genetic checkpoints. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,3,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11313421&form=6&db=m Rapid depletion of peripheral antigen-specific T cells in TCR-transgenic mice after oral administration of myelin basic protein. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11418656&form=6&db=m Pertussis toxin inhibits induction of tissue-specific autoimmune disease by disrupting G protein-coupled signals. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11445281&form=6&db=m Pertussis toxin-induced hyperacute autoimmune encephalomyelitis in Lewis rats is correlated with increased expression of inducible nitric oxide synthase and tumor necrosis factor alpha. causal interaction,unassigned 4,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11585627&form=6&db=m Defective CD4T cell priming and resistance to experimental autoimmune encephalomyelitis in TNF-deficient mice due to innate immune hypo-responsiveness. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12077236&form=6&db=m Pertussis toxin modulates the immune response to neuroantigens injected in incomplete Freund's adjuvant: induction of Th1 cells and experimental autoimmune encephalomyelitis in the presence of high frequencies of Th2 cells. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12411406&form=6&db=m Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12570705&form=6&db=m Poly(ADP-ribose) polymerase inhibitors. causal interaction,unassigned 4,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15159442&form=6&db=m The therapeutic effects of PJ34 [N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a selective inhibitor of poly(ADP-ribose) polymerase, in experimental allergic encephalomyelitis are associated with immunomodulation. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15210763&form=6&db=m The third signal in T cell-mediated autoimmune disease? therapeutic application,unassigned 1,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15236747&form=6&db=m Regulation of experimental autoimmune encephalomyelitis by CD4+, CD25+ and CD8+ T cells: analysis using depleting antibodies. therapeutic application,unassigned 2,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15557205&form=6&db=m TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease. diagnostic usage,therapeutic application,unassigned 2,3,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15931673&form=6&db=m Poly(ADP-ribose) polymerase-1 activation in a primate model of multiple sclerosis. ongoing research,unassigned 3,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16849462&form=6&db=m Pertussis toxin reduces the number of splenic Foxp3+ regulatory T cells. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16893572&form=6&db=m Diversified serum IgG response involving non-myelin CNS proteins during experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16970675&form=6&db=m Experimental Autoimmune Encephalomyelitis Develops in CC Chemokine Receptor 7-deficient Mice with Altered T-cell Responses. ongoing research,unassigned 3,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16982873&form=6&db=m Induction of Autoimmunity by Expansion of Autoreactive CD4+CD62Llow Cells In Vivo. therapeutic application,unassigned 1,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18500752&form=6&db=m Pertussis toxin induces angiogenesis in brain microvascular endothelial cells. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19628872&form=6&db=m PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20398738&form=6&db=m Kinetics of IL-17- and interferon-gamma-producing PLPp-specific CD4 T cells in EAE induced by coinjection of PLPp/IFA with pertussis toxin in SJL mice. ongoing research,unassigned 1,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20700542&form=6&db=m Paradoxical effect of pertussis toxin on the delayed hypersensitivity response to autoantigens in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20811645&form=6&db=m Centrally administered pertussis toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an EAE mouse model. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21209857&form=6&db=m Repetitive pertussis toxin promotes development of regulatory T cells and prevents central nervous system autoimmune disease. causal interaction,unassigned 2,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21343230&form=6&db=m PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21418369&form=6&db=m Crawling phagocytes recruited in the brain vasculature after pertussis toxin exposure through IL6, ICAM1, and ITG?M. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22419424&form=6&db=m The regulatory effect of liuwei dihuang pills on cytokines in mice with experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23489378&form=6&db=m Beyond dna repair,the immunological role of parp-1 and its siblings. therapeutic application,unassigned 4,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23607899&form=6&db=m Poly(ADP-ribose) polymerase 2 contributes to neuroinflammation and neurological dysfunction in mouse experimental autoimmune encephalomyelitis. therapeutic application,unassigned 2,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23660634&form=6&db=m Pertussis toxin attenuates experimental autoimmune encephalomyelitis by upregulating neuronal vascular endothelial growth factor. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24444779&form=6&db=m Attenuation of the progression of adjuvant-induced arthritis by 3-aminobenzamide treatment. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24486709&form=6&db=m Pertussis toxin modulates microglia and T cell profile to protect experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24730062&form=6&db=m Long-term suppression of EAE relapses by pharmacological impairment of epitope spreading. therapeutic application,unassigned 4,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25206651&form=6&db=m PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis. ongoing research,unassigned 3,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26616879&form=6&db=m Pertussis toxin promotes relapsing-remitting experimental autoimmune encephalomyelitis in Lewis rats. ongoing research,unassigned 2,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26724970&form=6&db=m The potential role of subclinical Bordetella Pertussis colonization in the etiology of multiple sclerosis. unassigned - 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26822306&form=6&db=m Immunomodulation By Subchronic Low Dose 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin. unassigned - 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28265351&form=6&db=m Elevated axonal membrane permeability and its correlation with motor deficits in an animal model of multiple sclerosis. ongoing research,unassigned 2,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29388727&form=6&db=m Special AT-rich sequence binding protein 1 is required for maintenance of T cell receptor responsiveness and development of experimental autoimmune encephalomyelitis. ongoing research,unassigned 1,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30001610&form=6&db=m Neuroprotective Effects of 6-Shogaol and Its Metabolite, 6-Paradol, in a Mouse Model of Multiple Sclerosis. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31454809&form=6&db=m Neuroinflammation and B-Cell Phenotypes in Cervical and Lumbosacral Regions of the Spinal Cord in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin. unassigned - 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31960801&form=6&db=m Protective effects of pharmacological therapies in animal models of multiple sclerosis: a review of studies 2014-2019. unassigned - 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33182064&form=6&db=m Amifostine ameliorates induction of experimental autoimmune encephalomyelitis: Effect on reactive oxygen species/NLRP3 pathway. ongoing research,unassigned 4,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33805762&form=6&db=m Pertussis Toxin Inhibits Encephalitogenic T-Cell Infiltration and Promotes a B-Cell-Driven Disease during Th17-EAE. therapeutic application,unassigned 4,0 2.4.2.30 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34310708&form=6&db=m Vascular and immunopathological role of Asymmetric Dimethylarginine (ADMA) in Experimental Autoimmune Encephalomyelitis. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Encephalomyelitis, Venezuelan Equine http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24335297&form=6&db=m Interferon-stimulated poly(ADP-Ribose) polymerases are potent inhibitors of cellular translation and virus replication. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Endodermal Sinus Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23486608&form=6&db=m PARP expression in germ cell tumours. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.4.2.30 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14961567&form=6&db=m Poly(ADP-ribose) polymerase-1, a novel partner of progesterone receptors in endometrial cancer and its precursors. causal interaction,diagnostic usage,unassigned 3,3,0 2.4.2.30 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32401642&form=6&db=m Autophagy in the physiological endometrium and cancer. unassigned - 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14961567&form=6&db=m Poly(ADP-ribose) polymerase-1, a novel partner of progesterone receptors in endometrial cancer and its precursors. causal interaction,diagnostic usage,unassigned 3,3,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17258405&form=6&db=m Poly(ADP-ribose) polymerase (PARP) and DNA-fragmentation factor (DFF45): expression and correlation in normal, hyperplastic and neoplastic endometrial tissues. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17303224&form=6&db=m Histone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20944090&form=6&db=m PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21913063&form=6&db=m PARP inhibitors in BRCA gene-mutated ovarian cancer and beyond. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23544495&form=6&db=m [Influence of pertussis toxin on GPER-mediated activation of phosphatidylinositol 3-kinase/protein kinase B signaling induced by 17?-estradiol in endometrial carcinoma cells]. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23762867&form=6&db=m Hypomethylation of ETS transcription factor binding sites and upregulation of PARP1 expression in endometrial cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24222661&form=6&db=m Low levels of circulating estrogen sensitize PTEN-null endometrial tumors to PARP inhibition in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24508840&form=6&db=m Expression of DNA repair proteins in endometrial cancer predicts disease outcome. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24625059&form=6&db=m Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24927325&form=6&db=m Effect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vitro. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28177128&form=6&db=m The SGK1 inhibitor SI113 induces autophagy, apoptosis, and endoplasmic reticulum stress in endometrial cancer cells. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454476&form=6&db=m PARP inhibition sensitizes endometrial cancer cells to paclitaxel-induced apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28886696&form=6&db=m Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28945226&form=6&db=m PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29937315&form=6&db=m Durable response in a woman with recurrent low-grade endometrioid endometrial cancer and a germline BRCA2 mutation treated with a PARP inhibitor. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30231353&form=6&db=m Moving From Mutation to Actionability. therapeutic application,unassigned 3,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30594176&form=6&db=m MLH1 enhances the sensitivity of human endometrial carcinoma cells to cisplatin by activating the MLH1/c-Abl apoptosis signaling pathway. unassigned - 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31069647&form=6&db=m Current Systemic Treatment Landscape of Advanced Gynecologic Malignancies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32360251&form=6&db=m Expression of poly-ADP-ribose polymerase (PARP) in endometrial adenocarcinoma: Prognostic potential. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32388810&form=6&db=m TRAF4 knockdown triggers synergistic lethality with simultaneous PARP1 inhibition in endometrial cancer. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32401642&form=6&db=m Autophagy in the physiological endometrium and cancer. unassigned - 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32497971&form=6&db=m PARP and PD-1/PD-L1 checkpoint inhibition in recurrent or metastatic endometrial cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32801862&form=6&db=m PARP Inhibitors in Endometrial Cancer: Current Status and Perspectives. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32988624&form=6&db=m An olaparib window-of-opportunity trial in patients with early-stage endometrial carcinoma: POLEN study. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33545804&form=6&db=m Successful treatment of a patient with brain metastases from endometrial cancer using Niraparib: a case report. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33882241&form=6&db=m PARP inhibitors and immunotherapy in ovarian and endometrial cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34134553&form=6&db=m Evaluation of the management of PARP inhibitor toxicities in ovarian and endometrial cancer within a multi-institution health-system. therapeutic application,unassigned 3,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34139979&form=6&db=m Research progress of PARP inhibitor monotherapy and combination therapy for endometrial cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30447298&form=6&db=m Immunohistochemistry expression of targeted therapies biomarkers in ovarian clear cell and endometrioid carcinomas (type I) and endometriosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12728305&form=6&db=m Nicotinamide increases systemic vascular resistance in ovine endotoxemia. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12744483&form=6&db=m Systemic and hepatosplanchnic hemodynamic and metabolic effects of the PARP inhibitor PJ34 during hyperdynamic porcine endotoxemia. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15197441&form=6&db=m Role of PARP on iNOS pathway during endotoxin-induced acute lung injury. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15793289&form=6&db=m Role of lipopolysaccharide and cecal ligation and puncture on blood coagulation and inflammation in sensitive and resistant mice models. diagnostic usage,unassigned 3,0 2.4.2.30 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21255617&form=6&db=m Heterotrimeric G?(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis. therapeutic application,unassigned 1,0 2.4.2.30 Enterocolitis, Necrotizing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21399558&form=6&db=m Poly(ADP-Ribose) Polymerase-1: A Novel Therapeutic Target in Necrotizing Enterocolitis. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18261157&form=6&db=m Post-allergen challenge inhibition of poly(ADP-ribose) polymerase harbors therapeutic potential for treatment of allergic airway inflammation. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18829681&form=6&db=m Reciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21276008&form=6&db=m PARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26205779&form=6&db=m PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Eosinophilic Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24238647&form=6&db=m Correlation of increased PARP14 and CCL26 expression in biopsies from children with eosinophilic esophagitis. unassigned - 2.4.2.30 Ependymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22184287&form=6&db=m PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Ependymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33186520&form=6&db=m Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8082634&form=6&db=m Amygdaloid kindling elicits persistent changes in pertussis toxin-catalyzed ADP-ribosylation. ongoing research,unassigned 4,0 2.4.2.30 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23201256&form=6&db=m Poly(ADP-ribose) polymerase inhibition protects epileptic hippocampal neurons from apoptosis via suppressing Akt-mediated apoptosis-inducing factor translocation in vitro. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23994215&form=6&db=m Cellular NAD depletion and decline of SIRT1 activity play critical roles in PARP-1-mediated acute epileptic neuronal death in vitro. causal interaction,unassigned 1,0 2.4.2.30 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31794795&form=6&db=m TRPM2 ion channel is involved in the aggravation of cognitive impairment and down regulation of epilepsy threshold in pentylenetetrazole-induced kindling mice. therapeutic application,unassigned 1,0 2.4.2.30 Epilepsy, Absence http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10587085&form=6&db=m Pertussis toxin decreases absence seizures and GABA(B) receptor binding in thalamus of a genetically prone rat (GAERS). ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Epstein-Barr Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1541543&form=6&db=m Generation of human monoclonal antibodies that confer protection against pertussis toxin. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16217393&form=6&db=m Poly(Adenosine diphosphate-ribose) polymerase inhibition preserves erectile function in rats after cavernous nerve injury. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20456626&form=6&db=m Poly(ADP-ribose) polymerase inhibition reverses nitrergic neurovascular dysfunctions in penile erectile tissue from streptozotocin-diabetic mice. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2890084&form=6&db=m Increase in intradermal vascular permeability caused by pertussis toxin from Bordetella pertussis. unassigned - 2.4.2.30 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12102657&form=6&db=m Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24033642&form=6&db=m Involvement of homologous recombination in the synergism between cisplatin and poly(ADP-ribose) polymerase inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27875549&form=6&db=m The Synthetic ?-Nitrostyrene Derivative CYT-Rx20 Inhibits Esophageal Tumor Growth and Metastasis via PI3K/AKT and STAT3 Pathways. therapeutic application,unassigned 1,0 2.4.2.30 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31002369&form=6&db=m Single?cell intratumoral stemness analysis reveals the involvement of cell cycle and DNA damage repair in two different types of esophageal cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31976528&form=6&db=m PARP inhibitor olaparib sensitizes esophageal carcinoma cells to fractionated proton irradiation. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33112558&form=6&db=m PARP1 Gene Polymorphisms and the Prognosis of Esophageal Cancer Patients from Cixian High-Incidence Region in Northern China. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0 2.4.2.30 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33528729&form=6&db=m PARP1 rs1136410 C/C genotype associated with an increased risk of esophageal cancer in smokers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.4.2.30 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24219164&form=6&db=m Effect of a poly(ADP-ribose) polymerase-1 inhibitor against esophageal squamous cell carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4 2.4.2.30 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28789382&form=6&db=m Poly (ADP-ribose) polymerase-1 inhibition decreases proliferation through G2/M arrest in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 2.4.2.30 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33112558&form=6&db=m PARP1 Gene Polymorphisms and the Prognosis of Esophageal Cancer Patients from Cixian High-Incidence Region in Northern China. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0 2.4.2.30 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33528729&form=6&db=m PARP1 rs1136410 C/C genotype associated with an increased risk of esophageal cancer in smokers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.4.2.30 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8888689&form=6&db=m Selectively enhanced cellular signaling by Gi proteins in essential hypertension. G alpha i2, G alpha i3, G beta 1, and G beta 2 are not mutated. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9498636&form=6&db=m Enhanced G protein activation in IDDM patients with diabetic nephropathy. causal interaction,unassigned 3,0 2.4.2.30 Exanthema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16412052&form=6&db=m Association of apoptosis-related microsatellite polymorphisms on chromosome 1q in Taiwanese systemic lupus erythematosus patients. unassigned - 2.4.2.30 Eye Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10611718&form=6&db=m Anterior uveitis in murine relapsing experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Fallopian Tube Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32172572&form=6&db=m Niraparib for the Treatment of Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1511990&form=6&db=m No abnormalities in the NAD+ ADP-ribosyltransferase (polymerizing) gene of transformed cells from a Fanconi's anemia patient. ongoing research,unassigned 2,0 2.4.2.30 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11926188&form=6&db=m The Fanconi anemia cell line HSC536N is not sensitive to interferon-gamma and does not cleave PARP in response to FAS-mediated cell killing. unassigned - 2.4.2.30 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12674511&form=6&db=m The cellular control enzyme polyADP ribosyl transferase is eliminated in cultured Fanconi anemia fibroblasts at confluency. ongoing research,unassigned 4,0 2.4.2.30 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22464251&form=6&db=m Rare mutations in XRCC2 increase the risk of breast cancer. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24130054&form=6&db=m Differential and common DNA repair pathways for topoisomerase I- and II-targeted drugs in a genetic DT40 repair cell screen panel. therapeutic application,unassigned 3,0 2.4.2.30 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25583207&form=6&db=m DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity. therapeutic application,unassigned 4,0 2.4.2.30 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25609062&form=6&db=m Acquisition of relative interstrand crosslinker resistance and PARP inhibitor sensitivity in Fanconi anemia head and neck cancers. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27503200&form=6&db=m A phase 1 study of the PARP inhibitor veliparib in combination with temozolomide in acute myeloid leukemia. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27740936&form=6&db=m Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30061540&form=6&db=m DNA Repair Deficient Chinese Hamster Ovary Cells Exhibiting Differential Sensitivity to Charged Particle Radiation under Aerobic and Hypoxic Conditions. ongoing research,unassigned 1,0 2.4.2.30 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31960047&form=6&db=m HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair. ongoing research,unassigned 3,0 2.4.2.30 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3629615&form=6&db=m Pertussis toxin induces fatty liver, hyperlipemia and ketosis in hamsters. unassigned - 2.4.2.30 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14767993&form=6&db=m Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25975270&form=6&db=m Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27848963&form=6&db=m Steatohepatitis: PARP inhibition protective against alcoholic steatohepatitis and NASH. therapeutic application,unassigned 4,0 2.4.2.30 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27979751&form=6&db=m PARP1-mediated PPAR? poly(ADP-ribosyl)ation suppresses fatty acid oxidation in non-alcoholic fatty liver disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 2.4.2.30 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27984176&form=6&db=m PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28013023&form=6&db=m Metabolic roles of poly(ADP-ribose) polymerases. diagnostic usage,unassigned 3,0 2.4.2.30 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29873790&form=6&db=m Hepatocyte-Specific Deletion of TIPARP, a Negative Regulator of the Aryl Hydrocarbon Receptor, Is Sufficient to Increase Sensitivity to Dioxin-Induced Wasting Syndrome. therapeutic application,unassigned 1,0 2.4.2.30 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34129049&form=6&db=m 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-Inducible Poly-ADP-Ribose Polymerase (TIPARP/PARP7) Catalytic Mutant Mice (TiparpH532A) Exhibit Increased Sensitivity to TCDD-Induced Hepatotoxicity and Lethality. unassigned - 2.4.2.30 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34450194&form=6&db=m PARPs in lipid metabolism and related diseases. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Fatty Liver, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27848963&form=6&db=m Steatohepatitis: PARP inhibition protective against alcoholic steatohepatitis and NASH. therapeutic application,unassigned 4,0 2.4.2.30 Fatty Liver, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27984176&form=6&db=m PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Fatty Liver, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29317476&form=6&db=m Poly(ADP-Ribose) Polymerase Inhibitor PJ34 Attenuated Hepatic Triglyceride Accumulation in Alcoholic Fatty Liver Disease in Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Fetal Alcohol Spectrum Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29327278&form=6&db=m Nicotinamide Inhibits Ethanol-Induced Caspase-3 and PARP-1 Over-activation and Subsequent Neurodegeneration in the Developing Mouse Cerebellum. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Fibroma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31855806&form=6&db=m PARP-1 expression as a prognostic factor in Desmoid-type fibromatosis. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Fibromatosis, Aggressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31855806&form=6&db=m PARP-1 expression as a prognostic factor in Desmoid-type fibromatosis. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14646226&form=6&db=m Response of DNA repair enzymes in murine fibrosarcoma, lymphosarcoma and ascites cells following gamma irradiation. diagnostic usage,unassigned 3,0 2.4.2.30 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21822690&form=6&db=m Role of JNK-1 regulation in the protection of contact-inhibited fibroblasts from oxidative stress. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30289618&form=6&db=m HMGA2 as a functional antagonist of PARP1 inhibitors in tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Friedreich Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26954031&form=6&db=m Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Frontotemporal Lobar Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32987654&form=6&db=m Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA. therapeutic application,unassigned 4,0 2.4.2.30 Gallbladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24566325&form=6&db=m Triptolide induces s phase arrest and apoptosis in gallbladder cancer cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Gallbladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34406176&form=6&db=m PARP1 rs1136410 (A/G) polymorphism is associated with early age of onset of gallbladder cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Ganglion Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12106139&form=6&db=m A G Protein Mediates the Inhibition of the Voltage-Dependent Potassium M Current by Muscarine, LHRH, Substance P and UTP in Bullfrog Sympathetic Neurons. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Ganglion Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25711635&form=6&db=m Poly(ADP-ribose) polymerase inhibition improves corneal epithelial innervation and wound healing in diabetic rats. diagnostic usage,unassigned 3,0 2.4.2.30 Gastrointestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28302009&form=6&db=m Expression and Single Nucleotide Polymorphism of Poly (ADPRibose) Polymerase-1 in Gastrointestinal Tumours: Clinical Involvement. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 2.4.2.30 Gastrointestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34532366&form=6&db=m Safety profile of poly (ADP-ribose) polymerase (PARP) inhibitors in cancer: a network meta-analysis of randomized controlled trials. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28302009&form=6&db=m Expression and Single Nucleotide Polymorphism of Poly (ADPRibose) Polymerase-1 in Gastrointestinal Tumours: Clinical Involvement. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 2.4.2.30 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33576344&form=6&db=m Identification of PARP-1 in cancer stem cells of gastrointestinal cancers: A preliminary study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34440228&form=6&db=m Therapeutic Potential of PARP Inhibitors in the Treatment of Gastrointestinal Cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7898478&form=6&db=m The function of poly (ADP-ribosylation) in DNA breakage and rejoining. unassigned - 2.4.2.30 Giant Cell Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15346059&form=6&db=m Bisphosphonates may reduce recurrence in giant cell tumor by inducing apoptosis. ongoing research,unassigned 2,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9879988&form=6&db=m Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11123719&form=6&db=m Expression of poly(ADP-ribose) polymerase and distribution of poly(ADP-ribosyl)ation in glioblastoma and in a glioma multicellular tumour spheroid model. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11772428&form=6&db=m Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12237842&form=6&db=m Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12481422&form=6&db=m Intratumor administration of interleukin 13 receptor-targeted cytotoxin induces apoptotic cell death in human malignant glioma tumor xenografts. unassigned - 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12700281&form=6&db=m Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14614022&form=6&db=m Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15771712&form=6&db=m Discovery of a perinecrotic 60 kDa MDM2 isoform within glioma spheroids and glioblastoma biopsy material. causal interaction,diagnostic usage,unassigned 3,1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15822818&form=6&db=m Comparative status of activated ERK1/2 and PARP cleavage in human gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16077913&form=6&db=m Synthetic chenodeoxycholic acid derivatives inhibit glioblastoma multiform tumor growth in vitro and in vivo. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17127074&form=6&db=m Poly(ADPR)polymerase-1 signalling of the DNA damage induced by DNA topoisomerase I poison in D54(p53wt) and U251(p53mut) glioblastoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19127268&form=6&db=m LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model. unassigned - 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19147766&form=6&db=m In vitro and in vivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19174557&form=6&db=m Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19318434&form=6&db=m Associations between polymorphisms in DNA repair genes and glioblastoma. causal interaction,diagnostic usage,unassigned 1,1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19519779&form=6&db=m A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas. ongoing research,unassigned 2,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20072652&form=6&db=m A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells. unassigned - 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20530668&form=6&db=m PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20532243&form=6&db=m Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20712901&form=6&db=m A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. unassigned - 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20716639&form=6&db=m Urokinase plasminogen activator receptor and/or matrix metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20879987&form=6&db=m Overcoming Resistance of Glioblastoma to Conventional Cytotoxic Therapies by the Addition of PARP Inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21775006&form=6&db=m Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22122467&form=6&db=m Temozolomide: Mechanisms of Action, Repair and Resistance. therapeutic application,unassigned 1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22472897&form=6&db=m PARP-1 protein expression in glioblastoma multiforme. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22794286&form=6&db=m Glioblastoma multiforme: overview of current treatment and future perspectives. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23011206&form=6&db=m PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells. ongoing research,unassigned 4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23510353&form=6&db=m Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23807292&form=6&db=m Poly (ADP-ribose) polymerase 1 protein expression in normal and neoplastic prostatic tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24032376&form=6&db=m Quercetin Increases the Efficacy of Glioblastoma Treatment Compared to Standard Chemoradiotherapy by the Suppression of PI-3-Kinase-Akt Pathway. therapeutic application,unassigned 4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24356817&form=6&db=m Glioblastoma Cells Containing Mutations in the Cohesin Component STAG2 Are Sensitive to PARP Inhibition. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24593254&form=6&db=m Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24647572&form=6&db=m ABCB1, ABCG2 and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapy. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24650937&form=6&db=m Rationale for PARP inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24724620&form=6&db=m Interleukin-4 Enhances PARP-Dependent DNA Repair Activity In Vitro. unassigned - 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24810052&form=6&db=m Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24838527&form=6&db=m Discordant in vitro and in vivo chemopotentiating effects of the PARP inhibitor veliparib in temozolomide-sensitive versus -resistant glioblastoma multiforme xenografts. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24970386&form=6&db=m PARPi-FL--a fluorescent PARP1 inhibitor for glioblastoma imaging. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25016928&form=6&db=m Caspase-dependent signaling underlies glioblastoma cell death in response to the fungal metabolite, fusarochromanone. unassigned - 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25182801&form=6&db=m Effect of p53 activity on the sensitivity of human glioblastoma cells to PARP-1 inhibitor in combination with topoisomerase I inhibitor or radiation. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25531448&form=6&db=m PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma. therapeutic application,unassigned 2,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25895168&form=6&db=m Dual-Modality Optical/PET Imaging of PARP1 in Glioblastoma. therapeutic application,unassigned 1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26040766&form=6&db=m PARP3 interacts with FoxM1 to confer glioblastoma cell radioresistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26337803&form=6&db=m Radioiodinated PARP1 tracers for glioblastoma imaging. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26438157&form=6&db=m Efficacy of PARP Inhibitor Rucaparib in Orthotopic Glioblastoma Xenografts Is Limited by Ineffective Drug Penetration into the Central Nervous System. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26469301&form=6&db=m Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP-ribose) Polymerase-1 (PARP-1) in Vivo. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26493053&form=6&db=m Non-invasive PET Imaging of PARP1 Expression in Glioblastoma Models. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26508094&form=6&db=m A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an NRG oncology RTOG group study. therapeutic application,unassigned 3,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26794465&form=6&db=m Enhanced efficacy of combined HDAC and PARP targeting in glioblastoma. therapeutic application,unassigned 3,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27655368&form=6&db=m Combining PARP inhibitors with radiation therapy for the treatment of glioblastoma: Is PTEN predictive of response? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28241425&form=6&db=m Heat Shock Factor 1 Depletion Sensitizes A172 Glioblastoma Cells to Temozolomide via Suppression of Cancer Stem Cell-Like Properties. therapeutic application,unassigned 4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28376211&form=6&db=m Rad51 Degradation: Role in Oncolytic Virus-Poly(ADP-Ribose) Polymerase Inhibitor Combination Therapy in Glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28654422&form=6&db=m PARP1 expression and its correlation with survival is tumour molecular subtype dependent in glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28947502&form=6&db=m Restricted Delivery of Talazoparib Across the Blood-Brain Barrier Limits the Sensitizing Effects of PARP Inhibition on Temozolomide Therapy in Glioblastoma. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29483558&form=6&db=m Radiosensitization Effect of Talazoparib, a Parp Inhibitor, on Glioblastoma Stem Cells Exposed to Low and High Linear Energy Transfer Radiation. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29572254&form=6&db=m PARP1-Targeted Radiotherapy in Mouse Models of Glioblastoma. unassigned - 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29630818&form=6&db=m An 18F-Labeled Poly(ADP-ribose) Polymerase Positron Emission Tomography Imaging Agent. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29780826&form=6&db=m Silibinin Induced Human Glioblastoma Cell Apoptosis Concomitant with Autophagy through Simultaneous Inhibition of mTOR and YAP. therapeutic application,unassigned 1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29935053&form=6&db=m Luteolin Decreases Epidermal Growth Factor Receptor-Mediated Cell Proliferation and Induces Apoptosis in Glioblastoma Cell Lines. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29961065&form=6&db=m Verbascoside Inhibits Glioblastoma Cell Proliferation, Migration and Invasion While Promoting Apoptosis Through Upregulation of Protein Tyrosine Phosphatase SHP-1 and Inhibition of STAT3 Phosphorylation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29974335&form=6&db=m Discriminating radiation injury from recurrent tumor with [18F]PARPi and amino acid PET in mouse models. ongoing research,unassigned 3,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30025493&form=6&db=m Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. ongoing research,unassigned 1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30127865&form=6&db=m MEG-3-mediated Wnt/?-catenin signaling pathway controls the inhibition of tunicamycin-mediated viability in glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30252484&form=6&db=m ABCB1 Attenuates the Brain Penetration of the PARP Inhibitor AZD2461. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30337641&form=6&db=m Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systems. therapeutic application,unassigned 1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30469352&form=6&db=m Functional Biological Activity of Sorafenib as a Tumor-Treating Field Sensitizer for Glioblastoma Therapy. therapeutic application,unassigned 1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30627327&form=6&db=m Eradication of LIG4-deficient glioblastoma cells by the combination of PARP inhibitor and alkylating agent. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655854&form=6&db=m Deubiquitinating enzyme 4 facilitates chemoresistance in glioblastoma by inhibiting P53 activity. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30723695&form=6&db=m PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31266951&form=6&db=m Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31619547&form=6&db=m Treatment of Pediatric Glioblastoma with Combination Olaparib and Temozolomide Demonstrates 2-Year Durable Response. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31827085&form=6&db=m Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. causal interaction,unassigned 1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31852834&form=6&db=m EGFR Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31900275&form=6&db=m Restoration of Temozolomide Sensitivity by PARP Inhibitors in Mismatch Repair Deficient Glioblastoma is Independent of Base Excision Repair. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32036474&form=6&db=m Exploitation of a novel phenothiazine derivative for its anti-cancer activities in malignant glioblastoma. ongoing research,unassigned 3,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32043779&form=6&db=m Treatment of Pediatric Glioblastoma with Combination Olaparib and Temozolomide Demonstrates 2-Year Durable Response. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32081041&form=6&db=m Investigation of U-251 cell death triggered by flavonoid luteolin: towards a better understanding on its anticancer property against glioblastomas. unassigned - 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32347934&form=6&db=m Pharmacokinetics, safety and tolerability of olaparib and temozolomide for recurrent glioblastoma: results of the phase I OPARATIC trial. therapeutic application,unassigned 2,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32443613&form=6&db=m A New Pathway Promotes Adaptation of Human Glioblastoma Cells to Glucose Starvation. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32527552&form=6&db=m PARP inhibitor cyanine dye conjugate with enhanced cytotoxic and antiproliferative activity in patient derived glioblastoma cell lines. ongoing research,unassigned 3,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32565597&form=6&db=m SB365 induces apoptosis and suppresses proliferation of glioblastoma cells. therapeutic application,unassigned 2,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32645394&form=6&db=m Sustained inhibition of PARP-1 activity delays glioblastoma recurrence by enhancing radiation-induced senescence. therapeutic application,unassigned 2,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32850156&form=6&db=m Poly (ADP-Ribose) Polymerase 1 Protein Expression in Normal Pancreas and Pancreatic Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33092495&form=6&db=m Cellular and biochemical antileukemic mechanisms of the meroterpenoid Oncocalyxone A. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33433610&form=6&db=m PARP mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O6-methylguanine DNA damage in glioblastoma. unassigned - 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33615184&form=6&db=m PARP Targeted Alpha-Particle Therapy Enhances Response to PD-1 Immune-Checkpoint Blockade in a Syngeneic Mouse Model of Glioblastoma. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33629929&form=6&db=m Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33984151&form=6&db=m A randomized phase II trial of veliparib, radiotherapy and temozolomide in patients with unmethylated MGMT glioblastoma: the VERTU study. unassigned - 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34039959&form=6&db=m BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34062758&form=6&db=m Polyphenolic Compounds of Crataegus Berry, Leaf, and Flower Extracts Affect Viability and Invasive Potential of Human Glioblastoma Cells. unassigned - 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34182476&form=6&db=m The Combination PARP Inhibitor Olaparib With Temozolomide in an Experimental Glioblastoma Model. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34195200&form=6&db=m VRK1 Depletion Facilitates the Synthetic Lethality of Temozolomide and Olaparib in Glioblastoma Cells. therapeutic application,unassigned 4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34381789&form=6&db=m RECQ1 Promotes Stress Resistance and DNA Replication Progression Through PARP1 Signaling Pathway in Glioblastoma. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34407687&form=6&db=m Tumor treating fields combined with a poly (adenosine diphosphate-ribose) polymerase inhibitor during radiotherapy for rapidly progressing IDH-wildtype diffuse astrocytoma: a case report. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34439854&form=6&db=m BRCAness as a Biomarker of Susceptibility to PARP Inhibitors in Glioblastoma Multiforme. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34454340&form=6&db=m The effect of iodine-131 beta-particles in combination with A-966492 and Topotecan on radio-sensitization of glioblastoma: An in-vitro study. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1323477&form=6&db=m Endothelin-elicited stimulation of phospholipase C is mediated by guanine nucleotide binding protein(s). ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1348983&form=6&db=m Synergism in cytosolic Ca2+ mobilization between bradykinin and agonists for pertussis toxin-sensitive G-protein-coupled receptors in NG 108-15 cells. unassigned - 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1361912&form=6&db=m Idazoxan down-regulates beta-adrenoceptors on C6 glioma cells in vitro. therapeutic application,unassigned 1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1725440&form=6&db=m Endothelin-induced activation of phosphoinositide turnover, calcium mobilization, and transmitter release in cultured neurons and neurally related cell types. therapeutic application,unassigned 3,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1847209&form=6&db=m Effect of chronic D-Ala,2 D-Leu5-enkephalin or pertussis toxin treatment on the high-affinity state of delta opioid receptor in neuroblastoma x glioma NG108-15 hybrid cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,1,1 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2302562&form=6&db=m Activation of a K+ conductance by bradykinin and by inositol-1,4,5-trisphosphate in rat glioma cells: involvement of intracellular and extracellular Ca2+. therapeutic application,unassigned 4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2426098&form=6&db=m Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2454296&form=6&db=m Chronic exposure to pertussis toxin alters muscarinic receptor-mediated regulation of cyclic AMP metabolism in neuroblastoma x glioma NG108-15 hybrid cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2551269&form=6&db=m ADP and, indirectly, ATP are potent inhibitors of cAMP production in intact isoproterenol-stimulated C6 glioma cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2886351&form=6&db=m Role of a protein regulating guanine nucleotide binding in phosphoinositide breakdown and calcium mobilization by bradykinin in neuroblastoma X glioma hybrid NG108-15 cells: effects of pertussis toxin and cholera toxin on receptor-mediated signal transduction. ongoing research,unassigned 3,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2981400&form=6&db=m Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2997225&form=6&db=m Effect of pertussis toxin treatment on the down-regulation of opiate receptors in neuroblastoma X glioma NG108-15 hybrid cells. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3025278&form=6&db=m Muscarinic cholinergic receptor-induced enhancement of PGE1-stimulated cAMP accumulation in neuroblastoma X glioma cells: prevention by pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3080332&form=6&db=m The GTP-binding regulatory proteins of neuroblastoma x glioma, NG108-15, and glioma, C6, cells. Immunochemical evidence of a pertussis toxin substrate that is neither Ni nor No. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3109499&form=6&db=m Guanine nucleotide regulation of the pertussis and cholera toxin substrates of rat glioma C6 BU1 cells. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3137927&form=6&db=m Opioid peptides promote cholera-toxin-catalysed ADP-ribosylation of the inhibitory guanine-nucleotide-binding protein (Gi) in membranes of neuroblastoma x glioma hybrid cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6300102&form=6&db=m Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6319865&form=6&db=m Pertussis toxin decreases opiate receptor binding and adenylate inhibition in a neuroblastoma x glioma hybrid cell line. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8263774&form=6&db=m Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8538647&form=6&db=m Identification of a 116 kDa protein able to bind 1,3-bis(2-chloroethyl)-1-nitrosourea-damaged DNA as poly(ADP-ribose) polymerase. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9616774&form=6&db=m Whole-body hyperthermia and ADPRT inhibition in experimental treatment of brain tumors. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10854828&form=6&db=m Poly(ADP-ribose) polymerase-independent potentiation of nitrosourea cytotoxicity by 3-aminobenzamide in human malignant glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10861802&form=6&db=m Pertussis toxin treatment prevents 5-HT(5a) receptor-mediated inhibition of cyclic AMP accumulation in rat C6 glioma cells. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10901171&form=6&db=m Differential effects of cholera toxin and pertussis toxin on the c-fos and c-jun mRNA expression in rat C6 glioma cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11123719&form=6&db=m Expression of poly(ADP-ribose) polymerase and distribution of poly(ADP-ribosyl)ation in glioblastoma and in a glioma multicellular tumour spheroid model. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11495343&form=6&db=m H2O2-induced cell death in human glioma cells: role of lipid peroxidation and PARP activation. ongoing research,unassigned 4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12237842&form=6&db=m Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12732355&form=6&db=m Molecular mechanisms for the activation of Ca2+-permeable nonselective cation channels by endothelin-1 in C6 glioma cells. therapeutic application,unassigned 1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14614022&form=6&db=m Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14715469&form=6&db=m Oxidative stress induces apoptosis in C6 glioma cells: involvement of mitogen-activated protein kinases and nuclear factor kappa B. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14751510&form=6&db=m PARP-1, PARP-2, and the cellular response to low doses of ionizing radiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313565&form=6&db=m Assays for G-protein-coupled receptor signaling using RGS-insensitive Galpha subunits. unassigned - 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15383633&form=6&db=m Endogenous regulator of g protein signaling proteins reduce {mu}-opioid receptor desensitization and down-regulation and adenylyl cyclase tolerance in C6 cells. ongoing research,unassigned 2,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15822818&form=6&db=m Comparative status of activated ERK1/2 and PARP cleavage in human gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16170028&form=6&db=m Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16385577&form=6&db=m Rho/ROCK pathway as a target of tumor therapy. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17047412&form=6&db=m The effects of phorbol 12-myristate 13-acetate, cholera toxin, prostaglandin E2 and norepinephrine on inducible nitric oxide synthase activation induced by lipopolysaccharide in C6 cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17196947&form=6&db=m Telomerase subunits expression variation between biopsy samples and cell lines derived from malignant glioma. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17900801&form=6&db=m AG490 influences UCN-01-induced cytotoxicity in Glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylation. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18056196&form=6&db=m Combination of measles virus virotherapy and radiation therapy has synergistic activity in the treatment of glioblastoma multiforme. therapeutic application,unassigned 1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18285510&form=6&db=m Endogenous regulators of G protein signaling differentially modulate full and partial mu-opioid agonists at adenylyl cyclase as predicted by a collision coupling model. ongoing research,unassigned 1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18525314&form=6&db=m Noscapine induces apoptosis in human glioma cells by an apoptosis-inducing factor-dependent pathway. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18616930&form=6&db=m Lysophosphatidylserine stimulates chemotactic migration in U87 human glioma cells. ongoing research,unassigned 3,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18954712&form=6&db=m Replication-dependent radiosensitization of human glioma cells by inhibition of poly(ADP-Ribose) polymerase: mechanisms and therapeutic potential. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19124499&form=6&db=m Association and interactions between DNA repair gene polymorphisms and adult glioma. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19533660&form=6&db=m PARP1 expression in pediatric central nervous system tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19587465&form=6&db=m Differential PARP cleavage: an indication for existence of multiple forms of cell death in human gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19661320&form=6&db=m mTOR, S6 and AKT expression in relation to proliferation and apoptosis/autophagy in glioma. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19671736&form=6&db=m Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19784808&form=6&db=m Doxorubicin-mediated apoptosis in glioma cells requires NFAT3. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20035051&form=6&db=m Oncoprotein Bmi-1 renders apoptotic resistance to glioma cells through activation of the IKK-nuclear factor-kappaB Pathway. therapeutic application,unassigned 1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20065494&form=6&db=m Large-conductance K+ channel openers induce death of human glioma cells. therapeutic application,unassigned 1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20142589&form=6&db=m Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20211558&form=6&db=m Genetic advances in glioma: susceptibility genes and networks. unassigned - 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20372790&form=6&db=m Induction of apoptosis in glioma cells requires cell-to-cell contact with human umbilical cord blood stem cells. diagnostic usage,unassigned 3,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20409643&form=6&db=m Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20868244&form=6&db=m Glioma risk associates with polymorphisms of DNA repair genes, XRCC1 and PARP1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21325073&form=6&db=m Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21377995&form=6&db=m N-methylpurine DNA glycosylase and DNA polymerase {beta} modulate BER inhibitor potentiation of glioma cells to temozolomide. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21479099&form=6&db=m Oxidative stress and PARP activation mediate the NADH-induced decrease in glioma cell survival. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21622128&form=6&db=m NADPH treatment decreases C6 glioma cell survival by increasing oxidative stress. unassigned - 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21849329&form=6&db=m Pediatric high-grade glioma: identification of poly(ADP-ribose) polymerase as a potential therapeutic target. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21947268&form=6&db=m Adjuvant immunotherapy of C6 glioma in rats with pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22083878&form=6&db=m The presumed atypical chemokine receptor CXCR7 signals through G(i/o) proteins in primary rodent astrocytes and human glioma cells. ongoing research,unassigned 3,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22127734&form=6&db=m Association between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22184287&form=6&db=m PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22276931&form=6&db=m Protein and phosphoprotein levels in glioma and adenocarcinoma cell lines grown in normoxia and hypoxia in monolayer and three-dimensional cultures. ongoing research,unassigned 3,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23211717&form=6&db=m The transcription factor Forkhead box P3 (FoxP3) is expressed in glioma cells and associated with increased apoptosis. unassigned - 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23241369&form=6&db=m 5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor. therapeutic application,unassigned 1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23987666&form=6&db=m 2'-Hydroxy C16-Ceramide Induces Apoptosis-Associated Proteomic Changes in C6 Glioma Cells. therapeutic application,unassigned 1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24197988&form=6&db=m Incidence and prognostic value of multiple gene promoter methylations in gliomas. causal interaction,diagnostic usage,unassigned 3,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24337403&form=6&db=m Concomitant treatment with pertussis toxin plus temozolomide increases the survival of rats bearing intracerebral RG2 glioma. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24500421&form=6&db=m Association between DNA repair gene polymorphisms and risk of glioma: A systematic review and meta-analysis. causal interaction,unassigned 2,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24738643&form=6&db=m Tetrandrine and caffeine modulated cell cycle and increased glioma cell death via caspase-dependent and caspase-independent apoptosis pathways. therapeutic application,unassigned 1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25273058&form=6&db=m A novel selenadiazole derivative induces apoptosis in human glioma cells by dephosphorylation of AKT. ongoing research,unassigned 3,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25441760&form=6&db=m [PARP inhibitors and radiotherapy: rational and prospects for a clinical use]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25576921&form=6&db=m PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant glioma. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25911198&form=6&db=m Association Between PARP1 Single Nucleotide Polymorphism and Brain Tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26367194&form=6&db=m Electro-hyperthermia inhibits glioma tumorigenicity through the induction of E2F1-mediated apoptosis. causal interaction,unassigned 3,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26505995&form=6&db=m Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26559910&form=6&db=m NPM1 histone chaperone is upregulated in glioblastoma to promote cell survival and maintain nucleolar shape. therapeutic application,unassigned 1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26683770&form=6&db=m Deoxypodophyllotoxin triggers parthanatos in glioma cells via induction of excessive ROS. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27055523&form=6&db=m Polymorphisms in DNA Repair Gene and Susceptibility to Glioma: A Systematic Review and Meta-Analysis Based on 33 Studies with 15 SNPs in 9 Genes. therapeutic application,unassigned 1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27181592&form=6&db=m JNK Activation Contributes to Oxidative Stress-Induced Parthanatos in Glioma Cells via Increase of Intracellular ROS Production. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27470408&form=6&db=m TCH1036, a indeno[1,2-c]quinoline derivative, potentially inhibited the growth of human brain malignant glioma (GBM) 8401 cells via suppression of the expression of Suv39h1 and PARP. ongoing research,unassigned 3,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27977780&form=6&db=m Pertussis Toxin Is a Robust and Selective Inhibitor of High Grade Glioma Cell Migration and Invasion. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27986595&form=6&db=m The CHAC1-inhibited Notch3 pathway is involved in temozolomide-induced glioma cytotoxicity. causal interaction,diagnostic usage,unassigned 3,2,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28148839&form=6&db=m 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28350112&form=6&db=m Contribution of caspase-independent pathway to apoptosis in malignant glioma induced by carbon ion beams. causal interaction,unassigned 1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28554130&form=6&db=m Betulinic acid derivative B10 inhibits glioma cell proliferation through suppression of SIRT1, acetylation of FOXO3a and upregulation of Bim/PUMA. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28654422&form=6&db=m PARP1 expression and its correlation with survival is tumour molecular subtype dependent in glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28743999&form=6&db=m Selenocysteine induces apoptosis in human glioma cells: evidence for TrxR1-targeted inhibition and signaling crosstalk. ongoing research,unassigned 2,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28777431&form=6&db=m Involvement of poly(ADP-ribose) polymerase-1 in Chinese patients with glioma: a potential target for effective patient care. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28858735&form=6&db=m Linarin suppresses glioma through inhibition of NF-?B/p65 and up-regulating p53 expression in vitro and in vivo. therapeutic application,unassigned 1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29592899&form=6&db=m Synthetic Lethality of PARP Inhibition and Ionizing Radiation is p53-dependent. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29793319&form=6&db=m Oroxyloside inhibits human glioma progression by suppressing proliferation, metastasis and inducing apoptosis related pathways. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30171426&form=6&db=m Rhaponticum carthamoides transformed root extract inhibits human glioma cells viability, induces double strand DNA damage, H2A.X phosphorylation, and PARP1 cleavage. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30252484&form=6&db=m ABCB1 Attenuates the Brain Penetration of the PARP Inhibitor AZD2461. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30450051&form=6&db=m Pre-treatment or Post-treatment of Human Glioma Cells With BIX01294, the Inhibitor of Histone Methyltransferase G9a, Sensitizes Cells to Temozolomide. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30678338&form=6&db=m The Selective Acetamidine-Based iNOS Inhibitor CM544 Reduces Glioma Cell Proliferation by Enhancing PARP-1 Cleavage In Vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30688446&form=6&db=m Fucoxanthin induces apoptosis in human glioma cells by triggering ROS-mediated oxidative damage and regulating MAPKs and PI3K/AKT pathways. unassigned - 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31281953&form=6&db=m Celastrol enhances TRAIL-induced apoptosis in human glioblastoma via the death receptor pathway. therapeutic application,unassigned 2,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31489712&form=6&db=m Impact of four lncRNA polymorphisms (rs2151280, rs7763881, rs1136410, and rs3787016) on glioma risk and prognosis: A case-control study. causal interaction,diagnostic usage,unassigned 4,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31619547&form=6&db=m Treatment of Pediatric Glioblastoma with Combination Olaparib and Temozolomide Demonstrates 2-Year Durable Response. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31810230&form=6&db=m Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31852834&form=6&db=m EGFR Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31900275&form=6&db=m Restoration of Temozolomide Sensitivity by PARP Inhibitors in Mismatch Repair Deficient Glioblastoma is Independent of Base Excision Repair. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32043779&form=6&db=m Treatment of Pediatric Glioblastoma with Combination Olaparib and Temozolomide Demonstrates 2-Year Durable Response. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32194873&form=6&db=m ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32229503&form=6&db=m Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32494639&form=6&db=m Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33157194&form=6&db=m A therapeutic update on PARP inhibitors: implications in the treatment of glioma. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33629929&form=6&db=m Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33719269&form=6&db=m [Toxic effects of Vitamin C combined with temozolomide on glioma cells and its mechanism]. unassigned - 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34242965&form=6&db=m Capitalizing on ATRX loss in glioma via PARP inhibition: Comment on "Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity" by Garbarino et al. therapeutic application,unassigned 1,0 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34477880&form=6&db=m Relationship between genetically determined telomere length and glioma risk. unassigned - 2.4.2.30 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Gliosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3932085&form=6&db=m Cellular regulation of poly(ADP) ribosylation of proteins. I. Comparison of hepatocytes, cultured cells and liver nuclei and the influence of varying concentrations of NAD. ongoing research,unassigned 4,0 2.4.2.30 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19264905&form=6&db=m Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19454727&form=6&db=m Poly(ADP-ribose) polymerase-1 regulates the progression of autoimmune nephritis in males by inducing necrotic cell death and modulating inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Glomerulonephritis, IGA http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29497996&form=6&db=m Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura. causal interaction,unassigned 3,0 2.4.2.30 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051636&form=6&db=m Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Graft vs Host Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26962294&form=6&db=m Reduced PARP1 as a Serum Biomarker for Graft Rejection in Kidney Transplantation. ongoing research,unassigned 1,0 2.4.2.30 Graft vs Host Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32923140&form=6&db=m Adoptive cell therapy of triple negative breast cancer with redirected cytokine-induced killer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Graves Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24956560&form=6&db=m Association of PARP-1, NF-?B, NF-?BIA and IL-6, IL-1? and TNF-? with Graves Disease and Graves Ophthalmopathy. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Graves Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28177666&form=6&db=m Poly (ADP-Ribose) Polymerase-1 (PARP-1) in Chinese patients with Graves Disease and Graves Ophthalmopathy. diagnostic usage,unassigned 3,0 2.4.2.30 Graves Ophthalmopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24956560&form=6&db=m Association of PARP-1, NF-?B, NF-?BIA and IL-6, IL-1? and TNF-? with Graves Disease and Graves Ophthalmopathy. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Graves Ophthalmopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28177666&form=6&db=m Poly (ADP-Ribose) Polymerase-1 (PARP-1) in Chinese patients with Graves Disease and Graves Ophthalmopathy. diagnostic usage,unassigned 3,0 2.4.2.30 Growth Hormone-Secreting Pituitary Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2880863&form=6&db=m Phorbol ester and phospholipase C-induced growth hormone secretion from pituitary somatotroph adenoma cells in culture: effects of somatostatin, bromocriptine, and pertussis toxin. ongoing research,unassigned 4,0 2.4.2.30 Haemophilus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1533239&form=6&db=m Effect of pertussis toxin on susceptibility of infant rats to Haemophilus influenzae type b. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.4.2.30 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18546267&form=6&db=m Synergistic inhibition of head and neck tumor growth by green tea (-)-epigallocatechin-3-gallate and EGFR tyrosine kinase inhibitor. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19672867&form=6&db=m Head and neck cancer radiosensitization by the novel poly(ADP-ribose) polymerase inhibitor GPI-15427. therapeutic application,unassigned 3,0 2.4.2.30 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21719137&form=6&db=m The poly(ADP-Ribose) polymerase inhibitor ABT-888 reduces radiation-induced nuclear EGFR and augments head and neck tumor response to radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.4.2.30 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21912620&form=6&db=m Cetuximab augments cytotoxicity with poly (adp-ribose) polymerase inhibition in head and neck cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24931630&form=6&db=m Photodynamic therapy (PDT) resistance by PARP1 regulation on PDT-induced apoptosis with autophagy in head and neck cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25017803&form=6&db=m Poly (ADP-ribose) polymerase inhibitor efficacy in head and neck cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25609062&form=6&db=m Acquisition of relative interstrand crosslinker resistance and PARP inhibitor sensitivity in Fanconi anemia head and neck cancers. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27686740&form=6&db=m Efficacy of poly (ADP-ribose) polymerase inhibitor olaparib against head and neck cancer cells: Predictions of drug sensitivity based on PAR-p53-NF-?B interactions. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30084837&form=6&db=m Final Report of a Phase I Trial of Olaparib with Cetuximab and Radiation for Heavy Smoker Patients with Locally Advanced Head and Neck Cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33133138&form=6&db=m Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth. therapeutic application,unassigned 4,0 2.4.2.30 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33862558&form=6&db=m PARP inhibitors in head and neck cancer: Molecular mechanisms, preclinical and clinical data. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10215997&form=6&db=m Neuronal accumulation of poly(ADP-ribose) after brain ischaemia. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15082289&form=6&db=m Role of poly(ADP-ribose) polymerase activation in the pathogenesis of cardiopulmonary dysfunction in a canine model of cardiopulmonary bypass. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15087818&form=6&db=m INO-1001 a novel poly(ADP-ribose) polymerase (PARP) inhibitor improves cardiac and pulmonary function after crystalloid cardioplegia and extracorporal circulation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15599141&form=6&db=m Mesenteric injury after cardiopulmonary bypass: role of poly(adenosine 5'-diphosphate-ribose) polymerase. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15681711&form=6&db=m Poly(ADP-ribose) polymerase inhibitor PJ-34 reduces mesenteric vascular injury induced by experimental cardiopulmonary bypass with cardiac arrest. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 2.4.2.30 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16525356&form=6&db=m Inhibition of poly(adp-ribose) polymerase reduces cardiomyocytic apoptosis after global cardiac arrest under cardiopulmonary bypass. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16480745&form=6&db=m In vitro effect of the potent poly(ADP-ribose) polymerase (PARP) inhibitor INO-1001 alone and in combination with aspirin, eptifibatide, tirofiban, enoxaparin or alteplase on haemostatic parameters. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21418809&form=6&db=m [Research progress of poly (ADP-ribose) polymerase-1 in cardiac diseases.] causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26218637&form=6&db=m Salvage of nicotinamide adenine dinucleotide plays a critical role in the bioenergetic recovery of post-hypoxic cardiomyocytes. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27561793&form=6&db=m 1,25(OH)2 D3 improves cardiac dysfunction, hypertrophy and fibrosis through PARP1/SIRT1/mTOR related mechanisms in Type 1 diabetes. causal interaction,diagnostic usage,unassigned 4,2,0 2.4.2.30 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29278652&form=6&db=m PARP1 induces cardiac fibrosis by mediating mTOR activity. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33326806&form=6&db=m Association study of hsa_circ_0001946, hsa-miR-7-5p and PARP1 in coronary atherosclerotic heart disease. causal interaction,unassigned 1,0 2.4.2.30 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33516841&form=6&db=m Comment on: Association study of hsa_circ_0001946, hsa-miR-7-5p and PARP1 in coronary atherosclerotic heart disease. ongoing research,unassigned 1,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1324064&form=6&db=m The effect of pertussis toxin on beta-adrenoceptor responses in isolated cardiac myocytes from noradrenaline-treated guinea-pigs and patients with cardiac failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1334992&form=6&db=m Role of altered G-protein expression in the regulation of myocardial adenylate cyclase activity and force of contraction in spontaneous hypertensive cardiomyopathy in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,1 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2156637&form=6&db=m Pertussis toxin treatment of whole blood. A novel approach to assess G protein function in congestive heart failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10371694&form=6&db=m Desensitization of cardiac beta-adrenoceptor signaling with heart failure produced by myocardial infarction in the rat. Evidence for the role of Gi but not Gs or phosphorylating proteins. therapeutic application,unassigned 1,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11145758&form=6&db=m Additional use of immunostaining for active caspase 3 and cleaved actin and PARP fragments to detect apoptosis in patients with chronic heart failure. diagnostic usage,unassigned 2,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11861791&form=6&db=m Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12225730&form=6&db=m Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15374823&form=6&db=m Increased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15385543&form=6&db=m Myocardial cell death and regeneration during progression of cardiac hypertrophy to heart failure. ongoing research,unassigned 3,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15523000&form=6&db=m Poly(ADP-Ribose) polymerase promotes cardiac remodeling, contractile failure, and translocation of apoptosis-inducing factor in a murine experimental model of aortic banding and heart failure. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15710350&form=6&db=m Poly(ADP-ribose) polymerase regulates myocardial calcium handling in doxorubicin-induced heart failure. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911332&form=6&db=m Cardioprotective effects of poly(ADP-ribose) polymerase inhibition. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15925705&form=6&db=m Nitrosative stress and pharmacological modulation of heart failure. unassigned - 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026319&form=6&db=m Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure. causal interaction,unassigned 4,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16207712&form=6&db=m Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391839&form=6&db=m Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16632544&form=6&db=m Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16716347&form=6&db=m PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17088946&form=6&db=m Activation of the poly(ADP-ribose) polymerase pathway in human heart failure. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17520094&form=6&db=m Poly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17919258&form=6&db=m Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18806606&form=6&db=m Effect of L-2286, a poly(ADP-ribose)polymerase inhibitor and enalapril on myocardial remodeling and heart failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19443425&form=6&db=m PARP inhibition delays transition of hypertensive cardiopathy to heart failure in spontaneously hypertensive rats. unassigned - 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19725100&form=6&db=m Fulminant pertussis: a multi-center study with new insights into the clinico-pathological mechanisms. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21697725&form=6&db=m Regulation of kinase cascade activation and heat shock protein expression by poly(ADP-ribose) polymerase inhibition in doxorubicin-induced heart failure. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21966394&form=6&db=m G?i)- and G?i3-specific regulation of voltage-dependent L-type calcium channels in cardiomyocytes. unassigned - 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23261455&form=6&db=m PARP-2 knockdown protects cardiomyocytes from hypertrophy via activation of SIRT1. causal interaction,unassigned 4,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24859603&form=6&db=m AG-690/11026014, a novel PARP-1 inhibitor, protects cardiomyocytes from AngII-induced hypertrophy. causal interaction,unassigned 4,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24997452&form=6&db=m Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy. causal interaction,unassigned 1,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25014216&form=6&db=m PARP-inhibitor treatment prevents hypertension induced cardiac remodeling by favorable modulation of heat shock proteins, Akt-1/GSK-3? and several PKC isoforms. causal interaction,unassigned 4,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26091340&form=6&db=m The Promise of Proteomics for the Study of ADP-Ribosylation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26346517&form=6&db=m Immobilization Stress With ?2-Adrenergic Stimulation Induces Regional and Transient Reduction of Cardiac Contraction Through Gi Coupling in Rats. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26707577&form=6&db=m Nicotinamide adenine dinucleotide homeostasis and signalling in heart disease: Pathophysiological implications and therapeutic potential. unassigned - 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27392900&form=6&db=m PARP inhibition and postinfarction myocardial remodeling. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29250299&form=6&db=m Oxidative Stress-Related Parthanatos of Circulating Mononuclear Leukocytes in Heart Failure. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29968072&form=6&db=m Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30041821&form=6&db=m PARP-1 inhibition attenuates cardiac fibrosis induced by myocardial infarction through regulating autophagy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32139900&form=6&db=m Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling. diagnostic usage,unassigned 3,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32411727&form=6&db=m DNA Damage, an Innocent Bystander in Atrial Fibrillation and Other Cardiovascular Diseases? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32616194&form=6&db=m Revealing the synergistic mechanism of Shenfu Decoction for anti-heart failure through network pharmacology strategy. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33110392&form=6&db=m E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33249529&form=6&db=m Protective effect of lncRNA CRNDE on myocardial cell apoptosis in heart failure by regulating HMGB1 cytoplasm translocation through PARP-1. therapeutic application,unassigned 2,0 2.4.2.30 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33421523&form=6&db=m Mitochondrial protective effects of PARP-inhibition in hypertension-induced myocardial remodeling and in stressed cardiomyocytes. therapeutic application,unassigned 3,0 2.4.2.30 Heart Valve Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33110392&form=6&db=m E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Hemangiosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34085099&form=6&db=m PARP inhibition in UV-associated angiosarcoma preclinical models. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,4,0 2.4.2.30 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11877304&form=6&db=m Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site. therapeutic application,unassigned 4,0 2.4.2.30 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21870265&form=6&db=m The Use of PARP Inhibitors in Cancer Therapy: Use as Adjuvant with Chemotherapy or Radiotherapy; Use as a Single Agent in Susceptible Patients; Techniques Used to Identify Susceptible Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24452810&form=6&db=m Population Pharmacokinetic Modeling of Veliparib (ABT-888) in Patients with Non-Hematologic Malignancies. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27894958&form=6&db=m Poly (ADP-ribose) polymerase inhibitors selectively induce cytotoxicity in TCF3-HLF-positive leukemic cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28695521&form=6&db=m The Use of PARP Inhibitors in Cancer Therapy: Use as Adjuvant with Chemotherapy or Radiotherapy, Use as a Single Agent in Susceptible Patients, and Techniques Used to Identify Susceptible Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Hemoglobinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7490518&form=6&db=m Neutrophil activation in response to immune complex-bearing endothelial cells depends on the functional cooperation of Fc gamma RII (CD32) and Fc gamma RIII (CD16). causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2 2.4.2.30 Hemoglobinuria, Paroxysmal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7490518&form=6&db=m Neutrophil activation in response to immune complex-bearing endothelial cells depends on the functional cooperation of Fc gamma RII (CD32) and Fc gamma RIII (CD16). causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2 2.4.2.30 Hemorrhagic Septicemia, Viral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34509626&form=6&db=m Molecular characterization and expressional analysis of two poly (ADP-ribose) polymerase (PARP) domain-containing Gig2 isoforms in rockfish (Sebastes schlegelii) and their antiviral activity against viral hemorrhagic septicemia virus. therapeutic application,unassigned 1,0 2.4.2.30 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8742498&form=6&db=m Influence of diet free of NAD-precursors on acetaminophen hepatotoxicity in mice. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22814620&form=6&db=m TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24089324&form=6&db=m Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28751426&form=6&db=m PARP2 deficiency affects invariant-NKT-cell maturation and protects mice from Concanavalin A-induced liver injury. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31694960&form=6&db=m Murine Coronavirus Infection Activates the Aryl Hydrocarbon Receptor in an Indoleamine 2,3-Dioxygenase-Independent Manner, Contributing to Cytokine Modulation and Proviral TCDD-Inducible-PARP Expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34115723&form=6&db=m Repurposing of Clinically Approved Poly-(Adp-Ribose) Polymerase Inhibitors For The Therapy of Sepsis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Hepatitis A http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26308112&form=6&db=m Concomitant use of VAQTA® with PedvaxHIB® and Infanrix® in 12 to 17 month old children. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Hepatitis A http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28233625&form=6&db=m Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10580209&form=6&db=m Immunogenicity study of a combined diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis vaccine used to reconstitute a freeze-dried Haemophilus influenzae type b vaccine (DTaP-IPV//PRP-T) administered simultaneously with a hepatitis B vaccine at two, three and four months of life. diagnostic usage,therapeutic application,unassigned 2,2,0 2.4.2.30 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11520252&form=6&db=m Antibody responses of healthy infants to concurrent administration of a bivalent haemophilus influenzae type b-hepatitis B vaccine with diphtheria-tetanus-pertussis, polio and measles-mumps-rubella vaccines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16410887&form=6&db=m Immunogenicity of a combined DTPa-HB vaccine co-administered with Haemophilus influenzae type B conjugate vaccine (PRP-T) for primary and booster vaccinations. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21276153&form=6&db=m No associations of polymorphisms in ADPRT with hepatitis B virus clearance and hepatocellular carcinoma occurrence in a Korean population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.4.2.30 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21721027&form=6&db=m Novel poly (ADP-ribose) polymerase 1 binding motif in hepatitis B virus core promoter impairs DNA damage repair. causal interaction,unassigned 1,0 2.4.2.30 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22863658&form=6&db=m A fully liquid DTaP-IPV-Hep B-PRP-T hexavalent vaccine for primary and booster vaccination of healthy Mexican children. therapeutic application,unassigned 1,0 2.4.2.30 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23910651&form=6&db=m Reduced ADP-ribosylation by PARP1 natural polymorphism V762A and by PARP1 inhibitors enhance Hepatitis B virus replication. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27041572&form=6&db=m Interaction of hepatitis B virus X protein with PARP1 results in inhibition of DNA repair in hepatocellular carcinoma. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27753797&form=6&db=m A Randomized, Controlled Study of DTaP-IPV-HB-PRP-T, a Fully Liquid Hexavalent Vaccine, Administered in a 3-, 5- and 11- to 12-month Schedule. diagnostic usage,unassigned 3,0 2.4.2.30 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28233625&form=6&db=m Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28714367&form=6&db=m PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.4.2.30 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28854796&form=6&db=m Hepatitis C virus induces oxidative stress and DNA damage by regulating DNAPKCs, ATM, ATR and PARP mediated signaling and guards cell from cancerous condition by upregulating RB, P53 and downregulating VEGF. ongoing research,unassigned 2,0 2.4.2.30 Hepatoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30271949&form=6&db=m PARP1 activation increases expression of modified tumor suppressors and pathways underlying development of aggressive hepatoblastoma. causal interaction,unassigned 3,0 2.4.2.30 Hepatoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31511432&form=6&db=m Wnt/?-catenin signaling as a useful therapeutic target in hepatoblastoma. causal interaction,unassigned 1,0 2.4.2.30 Hereditary Breast and Ovarian Cancer Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29650809&form=6&db=m [Molecular Targeted Therapies for Hereditary Cancer Syndrome]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Hereditary Breast and Ovarian Cancer Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34476650&form=6&db=m Hereditary pancreatic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Heredodegenerative Disorders, Nervous System http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31324530&form=6&db=m XRCC1 protein; Form and function. causal interaction,unassigned 4,0 2.4.2.30 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10536164&form=6&db=m Inhibition of poly(ADP-ribose)polymerase stimulates extrachromosomal homologous recombination in mouse Ltk-fibroblasts. therapeutic application,unassigned 1,0 2.4.2.30 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22013039&form=6&db=m Herpes simplex virus requires poly(ADP-ribose) polymerase activity for efficient replication and induces extracellular signal-related kinase-dependent phosphorylation and ICP0-dependent nuclear localization of tankyrase 1. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.4.2.30 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22623791&form=6&db=m Herpes simplex virus 1 infection activates poly(ADP-ribose) polymerase and triggers the degradation of poly(ADP-ribose) glycohydrolase. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30988430&form=6&db=m ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase ?-TrCP. therapeutic application,unassigned 1,0 2.4.2.30 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1562331&form=6&db=m A guanine nucleotide-binding regulatory protein in human sperm mediates acrosomal exocytosis induced by the human zona pellucida. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7888169&form=6&db=m Calcium influx into mouse spermatozoa activated by solubilized mouse zona pellucida, monitored with the calcium fluorescent indicator, fluo-3. Inhibition of the influx by three inhibitors of the zona pellucida induced acrosome reaction: tyrphostin A48, pertussis toxin, and 3-quinuclidinyl benzilate. unassigned - 2.4.2.30 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8442955&form=6&db=m Differential sensitivity of progesterone- and zona pellucida-induced acrosome reactions to pertussis toxin. ongoing research,unassigned 3,0 2.4.2.30 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8941070&form=6&db=m Inhibition of G protein in human sperm and its influence on acrosome reaction and zona pellucida binding. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10100483&form=6&db=m Evidence for the role of heterotrimeric guanine nucleotide-binding regulatory proteins in the regulation of the mouse sperm adenylyl cyclase by the egg's zona pellucida. therapeutic application,unassigned 2,0 2.4.2.30 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11303190&form=6&db=m Characterization of the biologic activities of a recombinant human zona pellucida protein 3 expressed in human ovarian teratocarcinoma (PA-1) cells. ongoing research,unassigned 2,0 2.4.2.30 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28233625&form=6&db=m Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33928900&form=6&db=m Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019. diagnostic usage,unassigned 2,0 2.4.2.30 Histiocytic Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17663173&form=6&db=m [Role of proteins in Fas-mediated apoptosis in tumor cells and lymphocytes co-cultured in vitro] ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 histone acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23377543&form=6&db=m Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. causal interaction,unassigned 3,0 2.4.2.30 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9371641&form=6&db=m A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis. ongoing research,unassigned 3,0 2.4.2.30 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14768058&form=6&db=m Inhibition of intra- and extra-cellular Tat function and HIV expression by pertussis toxin B-oligomer. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15746245&form=6&db=m Pertussis toxin B-oligomer inhibits HIV infection and replication in hu-PBL-SCID mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 2.4.2.30 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19857540&form=6&db=m Minireview, The oxidative stress-induced niacin sink (OSINS) model for HIV pathogenesis. causal interaction,unassigned 3,0 2.4.2.30 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26379653&form=6&db=m The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33063092&form=6&db=m Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16873024&form=6&db=m Discovery of bioactive small-molecule inhibitor of poly adp-ribose polymerase: implications for energy-deficient cells. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26252217&form=6&db=m PARP-1 Inhibition Is Neuroprotective in the R6/2 Mouse Model of Huntington's Disease. causal interaction,unassigned 1,0 2.4.2.30 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28824383&form=6&db=m Selective Sparing of Striatal Interneurons after Poly (ADP-Ribose) Polymerase 1 Inhibition in the R6/2 Mouse Model of Huntington's Disease. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33066292&form=6&db=m Modulation of Inflammasome and Pyroptosis by Olaparib, a PARP-1 Inhibitor, in the R6/2 Mouse Model of Huntington's Disease. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1318516&form=6&db=m Mediation of serotonin hyperalgesia by the cAMP second messenger system. therapeutic application,unassigned 3,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2010815&form=6&db=m Kappa- and delta-opioids block sympathetically dependent hyperalgesia. unassigned - 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2106149&form=6&db=m Chronic morphine administration and in vivo pertussis toxin treatment induce hyperalgesia and enhance 3H-nitrendipine binding. therapeutic application,unassigned 4,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2107404&form=6&db=m Intracerebroventricular treatment of mice with pertussis toxin induces hyperalgesia and enhances 3H-nitrendipine binding to synaptic membranes: similarity with morphine tolerance. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7477883&form=6&db=m Peripheral nociceptive effects of alpha 2-adrenergic receptor agonists in the rat. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7477899&form=6&db=m Mu-opioid agonist enhancement of prostaglandin-induced hyperalgesia in the rat: a G-protein beta gamma subunit-mediated effect? causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9150297&form=6&db=m Intrathecal pertussis toxin produces hyperalgesia and allodynia in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9839818&form=6&db=m Some new insights into the effects of opioids in phasic and tonic nociceptive tests. causal interaction,unassigned 3,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10884555&form=6&db=m Pharmacologic reversal of pertussis toxin-induced thermal allodynia in mice. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10974334&form=6&db=m Reversal of pertussis toxin-induced thermal allodynia by muscarinic cholinergic agonists in mice. therapeutic application,unassigned 1,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12573726&form=6&db=m Intrathecal pertussis toxin induces thermal hyperalgesia: involvement of excitatory and inhibitory amino acids. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14741774&form=6&db=m Reversal of ongoing thermal hyperalgesia in mice by a recombinant herpesvirus that encodes human preproenkephalin. ongoing research,unassigned 3,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16271370&form=6&db=m Protein kinase C inhibitor chelerythrine attenuates the morphine-induced excitatory amino acid release and reduction of the antinociceptive effect of morphine in rats injected intrathecally with pertussis toxin. therapeutic application,unassigned 2,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17976390&form=6&db=m PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18216775&form=6&db=m Ultra-low-dose naloxone restores the antinociceptive effect of morphine and suppresses spinal neuroinflammation in PTX-treated rats. ongoing research,unassigned 4,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19275929&form=6&db=m Activation of G(i) induces mechanical hyperalgesia poststress or inflammation. unassigned - 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19409222&form=6&db=m Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats and prevents glutamate transporter downregulation by suppressing the p38 mitogen-activated protein kinase signaling pathway. ongoing research,unassigned 2,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19463918&form=6&db=m N-Methyl-d-aspartate receptor antagonist d-AP5 prevents pertussis toxin-induced alterations in rat spinal cords by inhibiting increase in concentrations of spinal CSF excitatory amino acids and downregulation of glutamate transporters. unassigned - 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19900402&form=6&db=m Concurrent targeting of nitrosative stress-PARP pathway corrects functional, behavioral and biochemical deficits in experimental diabetic neuropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20980102&form=6&db=m RhoA/Rho kinase pathway contributes to the pathogenesis of thermal hyperalgesia in diabetic mice. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21617845&form=6&db=m Poly(ADP-ribose)polymerase inhibition counteracts renal hypertrophy and multiple manifestations of peripheral neuropathy in diabetic Akita mice. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22923475&form=6&db=m Marrow-Derived Cells Regulate the Development of Early Diabetic Retinopathy and Tactile Allodynia in Mice. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22971094&form=6&db=m PARP inhibitors attenuate chemotherapy-induced painful neuropathy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27714773&form=6&db=m Histamine H4 receptor agonist-induced relief from painful peripheral neuropathy is mediated by inhibition of spinal neuroinflammation and oxidative stress. causal interaction,unassigned 2,0 2.4.2.30 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32283287&form=6&db=m PARP-1-regulated TNF-? expression in the dorsal root ganglia and spinal dorsal horn contributes to the pathogenesis of neuropathic pain in rats. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1991383&form=6&db=m Loss of endothelial pertussis toxin-sensitive G protein function in atherosclerotic porcine coronary arteries. therapeutic application,unassigned 3,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11135624&form=6&db=m Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11812763&form=6&db=m The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15320813&form=6&db=m Antioxidant therapy in diabetic complications: what is new? unassigned - 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15504977&form=6&db=m Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15895395&form=6&db=m Poly(ADP-ribose)polymerase activity is reduced in circulating mononuclear cells from type 2 diabetic patients. causal interaction,ongoing research,unassigned 4,3,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026269&form=6&db=m Molecular targets of diabetic vascular complications and potential new drugs. unassigned - 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18078960&form=6&db=m Treatment with insulin inhibits poly(ADP-ribose)polymerase activation in a rat model of endotoxemia. causal interaction,diagnostic usage,unassigned 4,1,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20188823&form=6&db=m Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21617845&form=6&db=m Poly(ADP-ribose)polymerase inhibition counteracts renal hypertrophy and multiple manifestations of peripheral neuropathy in diabetic Akita mice. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22003936&form=6&db=m Comparative study of peripheral neuropathy and nerve regeneration in NOD and ICR diabetic mice. unassigned - 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22124463&form=6&db=m Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin. causal interaction,unassigned 4,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24201044&form=6&db=m Amelioration of diabetes-induced neurobehavioral and neurochemical changes by melatonin and nicotinamide: implication of oxidative stress-PARP pathway. causal interaction,unassigned 4,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24722243&form=6&db=m Parp inhibition prevents ten eleven translocase enzyme activation and hyperglycemia induced DNA demethylation. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25279990&form=6&db=m Hyperglycemia accentuates and ketonemia attenuates hypoglycemia-induced neuronal injury in the developing rat brain. unassigned - 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26200703&form=6&db=m Recurrent hypoinsulinemic hyperglycemia in neonatal rats increases PARP-1 and NF-?B expression and leads to microglial activation in the cerebral cortex. causal interaction,unassigned 3,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26807027&form=6&db=m Effect of D-glucose feeding on mortality induced by sepsis. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26986624&form=6&db=m Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade. therapeutic application,unassigned 1,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27027354&form=6&db=m Poly(ADP-ribose) polymerase 1 inhibition protects cardiomyocytes from inflammation and apoptosis in diabetic cardiomyopathy. causal interaction,diagnostic usage,unassigned 3,1,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27288104&form=6&db=m Poly-ADP-ribose polymerase inhibition enhances ischemic and diabetic wound healing by promoting angiogenesis. unassigned - 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27381826&form=6&db=m Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27612628&form=6&db=m PARP-1 inhibition alleviates diabetic cardiac complications in experimental animals. therapeutic application,unassigned 4,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28224182&form=6&db=m PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28883754&form=6&db=m The activation of ?2-adrenergic receptor in the spinal cord lowers sepsis-induced mortality. therapeutic application,unassigned 3,0 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29719509&form=6&db=m Mangiferin Enhanced Autophagy via Inhibiting mTORC1 Pathway to Prevent High Glucose-Induced Cardiomyocyte Injury. unassigned - 2.4.2.30 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34178859&form=6&db=m Propolis ethanol extract abrogates hyperglycemia, lipotoxicity, and lowered hepatic poly (ADP-ribose) polymerase protein level in male albino rats. ongoing research,unassigned 2,0 2.4.2.30 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16213988&form=6&db=m Melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18949543&form=6&db=m Poly (ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by hyperhomocysteinemia in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19776495&form=6&db=m Poly (ADP-Ribose) Polymerase Inhibition Attenuates Atherosclerotic Plaque Development in ApoE-/- Mice with Hyperhomocysteinemia. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7934972&form=6&db=m Acute stress-induced hyperinsulinemia in the pertussis toxin-treated rat: possible role of humoral beta-cell-tropic factors. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8502521&form=6&db=m Severe reactions associated with diphtheria-tetanus-pertussis vaccine: detailed study of children with seizures, hypotonic-hyporesponsive episodes, high fevers, and persistent crying. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.4.2.30 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33059000&form=6&db=m The quantitative analysis of the mechanism involved in pertussis toxin-mediated cell clustering and its implications in the in vitro quality control of diphtheria tetanus and whole cell pertussis vaccines. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Hyperkinesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1661865&form=6&db=m Neuropeptide Y and sigma ligand (JO 1784) act through a Gi protein to block the psychological stress and corticotropin-releasing factor-induced colonic motor activation in rats. unassigned - 2.4.2.30 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3629615&form=6&db=m Pertussis toxin induces fatty liver, hyperlipemia and ketosis in hamsters. unassigned - 2.4.2.30 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19776495&form=6&db=m Poly (ADP-Ribose) Polymerase Inhibition Attenuates Atherosclerotic Plaque Development in ApoE-/- Mice with Hyperhomocysteinemia. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34450194&form=6&db=m PARPs in lipid metabolism and related diseases. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1702304&form=6&db=m Hypersensitivity to clinically useful alkylating agents and radiation in poly(ADP-ribose) polymerase-deficient cell lines. therapeutic application,unassigned 1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3093086&form=6&db=m Mechanism by which pertussis toxin breaks unresponsiveness of delayed-type hypersensitivity to sheep red blood cells in mice. ongoing research,unassigned 4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3158403&form=6&db=m Break of unresponsiveness of delayed-type hypersensitivity to sheep red blood cells by pertussis toxin. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3228495&form=6&db=m Delayed-type hypersensitivity responses in mice treated with pertussis toxin and betamethasone. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6315242&form=6&db=m Effects of pertussis toxin on delayed-type hypersensitivity responses and on the activity of suppressor T cells on the responses. ongoing research,unassigned 4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6609000&form=6&db=m Effects of pertussis toxin (PT) on T-cell populations sensitized for delayed-type hypersensitivity in mice. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7977735&form=6&db=m Pertussis toxin stimulates hypersensitivity and enhances nerve-mediated antigen uptake in rat intestine. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8331165&form=6&db=m Enhancement of histamine-induced vascular leakage by pertussis toxin in SJL/J mice but not BALB/c mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9174984&form=6&db=m Use of type I and type IV hypersensitivity responses to define the immunopharmacological profile of drugs. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9645613&form=6&db=m Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28. therapeutic application,unassigned 2,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10436392&form=6&db=m Pertussis adjuvant prolongs intestinal hypersensitivity. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11024167&form=6&db=m Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12595443&form=6&db=m Analysis of the role of Bphs/Hrh1 in the genetic control of responsiveness to pertussis toxin. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15561303&form=6&db=m Poly(ADP-ribose) polymerases: homology, structural domains and functions. Novel therapeutical applications. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17242200&form=6&db=m RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair. unassigned - 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17257586&form=6&db=m Decreased PARP-1 levels accelerate embryonic lethality but attenuate neuronal apoptosis in DNA polymerase beta-deficient mice. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17430191&form=6&db=m Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19383921&form=6&db=m Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20096707&form=6&db=m Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage. causal interaction,unassigned 4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20233726&form=6&db=m Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20362325&form=6&db=m 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. ongoing research,unassigned 1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20725763&form=6&db=m Targeting poly(ADP-ribose) polymerase activity for cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21482670&form=6&db=m The USP1/UAF1 complex promotes double-strand break repair through homologous recombination. therapeutic application,unassigned 1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22116401&form=6&db=m Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2. therapeutic application,unassigned 2,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22246237&form=6&db=m Increased PARP-1 Association with DNA in Alkylation Damaged, PARP-Inhibited Mouse Fibroblasts. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23337751&form=6&db=m USP-11 as a predictive and prognostic factor following neoadjuvant therapy in women with breast cancer. therapeutic application,unassigned 4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23349304&form=6&db=m Microsatellite instability induced mutations in DNA repair genes Ctip and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors in myeloidmalignancies. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23355489&form=6&db=m Ataxia Telangiectasia Mutated (ATM) Is Dispensable for Endonuclease I-SceI-induced Homologous Recombination in Mouse Embryonic Stem Cells. causal interaction,unassigned 4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23388117&form=6&db=m The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23489378&form=6&db=m Beyond dna repair,the immunological role of parp-1 and its siblings. therapeutic application,unassigned 4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24444779&form=6&db=m Attenuation of the progression of adjuvant-induced arthritis by 3-aminobenzamide treatment. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24598253&form=6&db=m PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24695737&form=6&db=m The ADP-ribosyltransferase PARP10/ARTD10 interacts with Proliferating Cell Nuclear Antigen (PCNA) and is required for DNA damage tolerance. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24770870&form=6&db=m Base excision repair defects invoke hypersensitivity to PARP inhibition. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25441760&form=6&db=m [PARP inhibitors and radiotherapy: rational and prospects for a clinical use]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25753673&form=6&db=m A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26505995&form=6&db=m Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26979391&form=6&db=m Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27503931&form=6&db=m Inhibiting Mitochondrial DNA Ligase III? Activates Caspase 1-Dependent Apoptosis in Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28535155&form=6&db=m Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28560323&form=6&db=m CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28634224&form=6&db=m IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28674486&form=6&db=m Advanced Oxidative Protein Products Cause Pain Hypersensitivity in Rats by Inducing Dorsal Root Ganglion Neurons Apoptosis via NADPH Oxidase 4/c-Jun N-terminal Kinase Pathways. therapeutic application,unassigned 1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29187880&form=6&db=m The PARP-1 inhibitor Olaparib suppresses BRCA1 protein levels, increases apoptosis and causes radiation hypersensitivity in BRCA1 causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29196727&form=6&db=m Hypersensitivity of BRCA2 deficient cells to rosemary extract explained by weak PARP inhibitory activity. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29511213&form=6&db=m Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29529298&form=6&db=m Human CHD1 is required for early DNA-damage signaling and is uniquely regulated by its N terminus. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29620483&form=6&db=m DNA repair and cell cycle checkpoint defects in a mouse model of 'BRCAness' are partially rescued by 53BP1 deletion. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29626126&form=6&db=m APTO-253 Is a New Addition to the Repertoire of Drugs that Can Exploit DNA BRCA1/2 Deficiency. ongoing research,unassigned 1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29654063&form=6&db=m A Short BRCA2-Derived Cell-Penetrating Peptide Targets RAD51 Function and Confers Hypersensitivity toward PARP Inhibition. therapeutic application,unassigned 3,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29992957&form=6&db=m Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30255380&form=6&db=m Impact of carboplatin hypersensitivity and desensitization on patients with recurrent ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30348635&form=6&db=m The Ewing Family of Tumors Relies on BCL-2 and BCL-XL to Escape PARP Inhibitor Toxicity. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30389154&form=6&db=m Modulation of hypersensitivity to oxidative DNA damage in ATM defective cells induced by potassium bromate by inhibition of the Poly (ADP-ribose) polymerase (PARP). causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30470508&form=6&db=m Loss of the p12 subunit of DNA polymerase delta leads to a defect in HR and sensitization to PARP inhibitors. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30982887&form=6&db=m LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation. unassigned - 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32743550&form=6&db=m Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33787008&form=6&db=m Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Hypersensitivity, Delayed http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20700542&form=6&db=m Paradoxical effect of pertussis toxin on the delayed hypersensitivity response to autoantigens in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9504380&form=6&db=m Effects of quinapril, losartan and hydralazine on cardiac hypertrophy and beta-adrenergic neuroeffector mechanisms in transgenic (mREN2)27 rats. ongoing research,unassigned 4,0 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10386237&form=6&db=m Pertussis toxin-sensitive G-proteins and regulation of blood pressure in the spontaneously hypertensive rat. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12011985&form=6&db=m Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12169651&form=6&db=m Inactivation of enhanced expression of G(i) proteins by pertussis toxin attenuates the development of high blood pressure in spontaneously hypertensive rats. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15502880&form=6&db=m Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation. unassigned - 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026319&form=6&db=m Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure. causal interaction,unassigned 4,0 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19549508&form=6&db=m PCB-induced endothelial cell dysfunction: role of poly(ADP-ribose) polymerase. causal interaction,unassigned 3,0 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19961262&form=6&db=m Influence of pertussis toxin pretreatment on the development of L-NAME-induced hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20224433&form=6&db=m Role of nifedipine-sensitive sympathetic vasoconstriction in maintenance of high blood pressure in spontaneously hypertensive rats: effect of Gi-protein inactivation by pertussis toxin. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20619687&form=6&db=m iNOS induction and PARP-1 activation in human atherosclerotic lesions: an immunohistochemical and ultrastructural approach. causal interaction,unassigned 4,0 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20713914&form=6&db=m Impaired 3',5'-cyclic adenosine monophosphate-mediated signaling in immediate early responsive gene X-1-deficient vascular smooth muscle cells. ongoing research,unassigned 2,0 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22339234&form=6&db=m Contribution of poly(ADP-ribose) polymerase to endothelial dysfunction and hypertension in a rat model of pre-eclampsia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22846599&form=6&db=m Inhibition of PARP prevents angiotensin II-induced aortic fibrosis in rats. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25014216&form=6&db=m PARP-inhibitor treatment prevents hypertension induced cardiac remodeling by favorable modulation of heat shock proteins, Akt-1/GSK-3? and several PKC isoforms. causal interaction,unassigned 4,0 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26986624&form=6&db=m Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade. therapeutic application,unassigned 1,0 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27912212&form=6&db=m Knockdown of Inhibitory Guanine Nucleotide Binding Protein Gi?-2 by Antisense Oligodeoxynucleotides Attenuates the Development of Hypertension and Tachycardia in Spontaneously Hypertensive Rats. unassigned - 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28660007&form=6&db=m MicroRNAs Modulate Oxidative Stress in Hypertension through PARP-1 Regulation. causal interaction,unassigned 4,0 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31683401&form=6&db=m [Gender-specific factors of ischemic stroke among atrial fibrillation patients]. unassigned - 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33099187&form=6&db=m Therapeutic options following second-line platinum-based chemotherapy in patients with recurrent ovarian cancer: Comparison of active surveillance and maintenance treatment. causal interaction,unassigned 4,0 2.4.2.30 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33110392&form=6&db=m E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7475894&form=6&db=m Effects of calcium channel antagonists and pertussis toxin on noradrenaline-induced contractions in pulmonary artery from pulmonary hypertensive rats. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25481773&form=6&db=m Poly (ADP-ribose) polymerase-1: An emerging target in right ventricle dysfunction associated with pulmonary hypertension. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26201953&form=6&db=m MicroRNAs and PARP: co-conspirators with ROS in pulmonary hypertension. Focus on "miR-223 reverses experimental pulmonary arterial hypertension". causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29592985&form=6&db=m Caffeine to prevent respiratory failure and improve outcome in infant pertussis. causal interaction,unassigned 4,0 2.4.2.30 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33110392&form=6&db=m E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34145457&form=6&db=m Pertussis toxin promotes pulmonary hypertension in an infant mouse model of Bordetella pertussis infection. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3011106&form=6&db=m Pertussis toxin effects on adenylate cyclase activity, cyclic AMP accumulation and lipolysis in adipocytes from hypothyroid, euthyroid and hyperthyroid rats. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8471065&form=6&db=m Tissue- and subunit-specific regulation of G-protein expression by hypo- and hyperthyroidism. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11093944&form=6&db=m Poly(ADP-ribose) polymerase is affected early by thyroid state during liver regeneration in rats. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19082780&form=6&db=m Poly(ADP-ribosyl)ation of proteins and germ cell development in hyperthyroid rat testes. unassigned - 2.4.2.30 Hypertrophy, Right Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25481773&form=6&db=m Poly (ADP-ribose) polymerase-1: An emerging target in right ventricle dysfunction associated with pulmonary hypertension. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8502521&form=6&db=m Severe reactions associated with diphtheria-tetanus-pertussis vaccine: detailed study of children with seizures, hypotonic-hyporesponsive episodes, high fevers, and persistent crying. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.4.2.30 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9582299&form=6&db=m Signaling pathways involved in thrombin-induced cell protection. therapeutic application,unassigned 2,0 2.4.2.30 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14627653&form=6&db=m Hypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15262265&form=6&db=m Zinc release contributes to hypoglycemia-induced neuronal death. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15855333&form=6&db=m Pyruvate administered after severe hypoglycemia reduces neuronal death and cognitive impairment. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15908393&form=6&db=m Infection of newborn piglets with Bordetella pertussis: a new model for pertussis. ongoing research,unassigned 1,0 2.4.2.30 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19687776&form=6&db=m Postnatal Age Influences Hypoglycemia-induced Poly(ADP-ribose) Polymerase-1 Activation in the Brain Regions of Rats. causal interaction,ongoing research,unassigned 2,4,0 2.4.2.30 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22453629&form=6&db=m Prevention of acute/severe hypoglycemia-induced neuron death by lactate administration. therapeutic application,unassigned 1,0 2.4.2.30 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24278448&form=6&db=m Pyruvate administration reduces recurrent/moderate hypoglycemia-induced cortical neuron death in diabetic rats. causal interaction,unassigned 4,0 2.4.2.30 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33059000&form=6&db=m The quantitative analysis of the mechanism involved in pertussis toxin-mediated cell clustering and its implications in the in vitro quality control of diphtheria tetanus and whole cell pertussis vaccines. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1963570&form=6&db=m Mechanism of the cardiovascular effects of GABAB receptor activation in the nucleus tractus solitarii of the rat. ongoing research,unassigned 3,0 2.4.2.30 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2875890&form=6&db=m Vascular beta-adrenoceptor blocking activity of endotoxin and pertussis toxin from Bordetella pertussis in rats. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10771174&form=6&db=m The neuroprotective effect of cerebral poly(ADP-ribose)polymerase inhibition in a rat model of global ischemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18475194&form=6&db=m Activation and modulation of cardiac poly-adenosine diphosphate ribose polymerase activity in a rat model of brain death. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25895143&form=6&db=m Inhibition of Nitro-Oxidative Stress Attenuates Pulmonary and Systemic Injury Induced by High-Tidal Volume Mechanical Ventilation. causal interaction,unassigned 3,0 2.4.2.30 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8471065&form=6&db=m Tissue- and subunit-specific regulation of G-protein expression by hypo- and hyperthyroidism. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23260200&form=6&db=m Regulation of myofibroblast differentiation by poly(ADP-ribose) polymerase 1. ongoing research,unassigned 3,0 2.4.2.30 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31164820&form=6&db=m Effects of PARP-1 Deficiency and Histamine H4 Receptor Inhibition in an Inflammatory Model of Lung Fibrosis in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Immune Complex Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29975827&form=6&db=m [THE EFFECT OF OF POLY(ADP-RIBOSE) POLYMERASE INHIBITOR 4-HYDROXY-QUINAZOLINE ON DEATH OF IMMUNE CELLS UNDER IMMUNE COMPLEX-MEDIATED INJURY IN MICE]. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Immune System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17579050&form=6&db=m A key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturation. therapeutic application,unassigned 4,0 2.4.2.30 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9334719&form=6&db=m Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9740102&form=6&db=m Enhanced poly(ADP-ribosyl)ation after focal ischemia in rat brain. ongoing research,unassigned 4,0 2.4.2.30 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11595210&form=6&db=m Long-term neuroprotective effect of inhibiting poly(ADP-ribose) polymerase in rats with middle cerebral artery occlusion using a behavioral assessment. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12628750&form=6&db=m Poly(ADP-ribose) polymerase as a key player in excitotoxicity and post-ischemic brain damage. therapeutic application,unassigned 4,0 2.4.2.30 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12973923&form=6&db=m Influence of electroacupuncture on the mRNA of heat shock protein 70 and 90 in brain after cerebral ischemia/reperfusion of rats. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14977067&form=6&db=m Neuroprotective effect of combination of poly (ADP-ribose) polymerase inhibitor and antioxidant in middle cerebral artery occlusion induced focal ischemia in rats. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15168908&form=6&db=m Neuroprotective effect of 4-amino-1,8-napthalimide, a poly(ADP ribose) polymerase inhibitor in middle cerebral artery occlusion-induced focal cerebral ischemia in rat. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,2,0 2.4.2.30 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16202986&form=6&db=m Neuroprotective effects of KCL-440, a new poly(ADP-ribose) polymerase inhibitor, in the rat middle cerebral artery occlusion model. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16935310&form=6&db=m Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17433265&form=6&db=m Poly(ADP-ribose) polymerase inhibition by cilostazol is implicated in the neuroprotective effect against focal cerebral ischemic infarct in rat. causal interaction,unassigned 2,0 2.4.2.30 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19190654&form=6&db=m Sex differences in minocycline-induced neuroprotection after experimental stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20955770&form=6&db=m Tumor necrosis factor-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 mediate cerebral ischemia-induced poly(ADP-ribose) polymerase-1 activation and neuronal death. ongoing research,unassigned 2,0 2.4.2.30 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21741620&form=6&db=m MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor, ameliorates ischemic brain damage in a non-human primate model. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25924998&form=6&db=m Poly(ADP-Ribose)Polymerase 1 (PARP-1) Activation and Ca(2+) Permeable ?-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Channels in Post-Ischemic Brain Damage: New Therapeutic Opportunities? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26365274&form=6&db=m Pertussis toxin reduces calcium influx to protect ischemic stroke in a middle cerebral artery occlusion model. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29852289&form=6&db=m Sex differences in the effects of PARP inhibition on microglial phenotypes following neonatal stroke. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29938598&form=6&db=m Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke. unassigned - 2.4.2.30 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32317937&form=6&db=m Delayed PARP-1 Inhibition Alleviates Post-stroke Inflammation in Male Versus Female Mice: Differences and Similarities. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=112058&form=6&db=m Production of exoenzyme S during Pseudomonas aeruginosa infections of burned mice. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1398968&form=6&db=m Proliferative responses and gamma interferon and tumor necrosis factor production by lymphocytes isolated from tracheobroncheal lymph nodes and spleen of mice aerosol infected with Bordetella pertussis. therapeutic application,unassigned 2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1533239&form=6&db=m Effect of pertussis toxin on susceptibility of infant rats to Haemophilus influenzae type b. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1539974&form=6&db=m Construction of Bordetella pertussis strains that overproduce genetically inactivated pertussis toxin. therapeutic application,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1703192&form=6&db=m Modulation of Bordetella pertussis infection with monoclonal antibodies to pertussis toxin. diagnostic usage,ongoing research,unassigned 2,4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1708105&form=6&db=m Epitope specificity of three anti-pertussis toxin monoclonal antibodies with dissimilar effects in assays of toxin neutralizing activity. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1737935&form=6&db=m Stimulus-response coupling in monocytes infected with Leishmania. Attenuation of calcium transients is related to defective agonist-induced accumulation of inositol phosphates. therapeutic application,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1894354&form=6&db=m Contribution of the B oligomer to the protective activity of genetically attenuated pertussis toxin. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2019753&form=6&db=m Evaluation of serology and nasopharyngeal cultures for diagnosis of pertussis in a vaccine efficacy trial. causal interaction,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159104&form=6&db=m Serum antibody response to B. pertussis Tn5 mutants, purified PT and FHA in two different mouse strains and passive protection in the murine intranasal infection model. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2254030&form=6&db=m Mechanism of pertussis toxin B oligomer-mediated protection against Bordetella pertussis respiratory infection. therapeutic application,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2313126&form=6&db=m Widespread silent transmission of pertussis in families: antibody correlates of infection and symptomatology. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2401570&form=6&db=m Adenylate cyclase toxin is critical for colonization and pertussis toxin is critical for lethal infection by Bordetella pertussis in infant mice. causal interaction,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2536779&form=6&db=m Human serum antibody responses to Bordetella pertussis infection and pertussis vaccination. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537490&form=6&db=m Impaired formation of the second messenger cAMP in mononuclear blood cells of children with pertussis. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2572561&form=6&db=m Lethal infection by Bordetella pertussis mutants in the infant mouse model. causal interaction,unassigned 2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2572651&form=6&db=m Serum IgG, IgA, and IgM responses to pertussis toxin, filamentous hemagglutinin, and agglutinogens 2 and 3 after infection with Bordetella pertussis and immunization with whole-cell pertussis vaccine. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2768444&form=6&db=m Subclass compositions of immunoglobulin G to pertussis toxin in patients with whooping cough, in healthy individuals, and in recipients of a pertussis toxoid vaccine. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2857752&form=6&db=m Neutralizing antibodies to pertussis toxin in whooping cough. diagnostic usage,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2988426&form=6&db=m Contribution of exoenzyme S to the virulence of Pseudomonas aeruginosa. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2988944&form=6&db=m Use of transposon mutants to assess the role of exoenzyme S in chronic pulmonary disease due to Pseudomonas aeruginosa. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2988945&form=6&db=m Role of exoenzyme S in chronic Pseudomonas aeruginosa lung infections. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2995500&form=6&db=m The role of exoenzyme S in infections with Pseudomonas aeruginosa. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3000148&form=6&db=m Genetic approaches to study Pseudomonas aeruginosa protein antigens. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3018037&form=6&db=m Phenotypic comparison of Pseudomonas aeruginosa strains isolated from a variety of clinical sites. diagnostic usage,ongoing research,unassigned 4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3045244&form=6&db=m Role of the adrenal medulla in stress-induced hyperinsulinaemia in normal mice and in mice infected with Bordetella pertussis or treated with pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3089661&form=6&db=m Role of Pseudomonas aeruginosa extracellular enzymes in lung disease. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6086529&form=6&db=m Isolation and characterization of transposon-induced mutants of Pseudomonas aeruginosa deficient in production of exoenzyme S. ongoing research,unassigned 3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6088647&form=6&db=m Pertussis toxin and extracytoplasmic adenylate cyclase as virulence factors of Bordetella pertussis. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6094351&form=6&db=m Monoclonal antibody against pertussis toxin: effect on toxin activity and pertussis infections. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6542069&form=6&db=m Bordetella pertussis infection in mice: correlation of specific antibodies against two antigens, pertussis toxin, and filamentous hemagglutinin with mouse protectivity in an intracerebral or aerosol challenge system. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7510256&form=6&db=m Structural relationship between the S1 and S4 subunits of pertussis toxin. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7536288&form=6&db=m Elucidation of linear epitopes of pertussis toxin using overlapping synthetic decapeptides: identification of a human B-cell determinant in the S1 subunit indicative of acute infections. ongoing research,unassigned 2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7639731&form=6&db=m Poly(ADP-ribose) polymerase activity in various U937 cell subclones with different susceptibility to HIV-1 infection: its dramatic decrease following persistent virus infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7689056&form=6&db=m Histamine release from basophils in childhood: age dependency and inhibition by pertussis infection and pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7957264&form=6&db=m Role of pertussis toxin in causing symptoms of Bordetella parapertussis infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7999145&form=6&db=m Characterization of murine lung inflammation after infection with parental Bordetella pertussis and mutants deficient in adhesins or toxins. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8106134&form=6&db=m Chick embryo, a model to study the lethal activity of pertussis toxin, infectivity of Bordetella pertussis, and their neutralization by immune sera. ongoing research,unassigned 2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8223658&form=6&db=m Western blot analysis of antibody responses of young infants to pertussis infection. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8253976&form=6&db=m Comparison of polymerase chain reaction, culture, and western immunoblot serology for diagnosis of Bordetella pertussis infection. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8301665&form=6&db=m Evidence that myocardial pertussis toxin substrates are uniquely altered in acute murine Chagas' disease in a manner unrelated to myocardial dysfunction. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8423077&form=6&db=m Bordetella pertussis and Bordetella parapertussis: two immunologically distinct species. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8440945&form=6&db=m Interferon-gamma levels in serum and bronchoalveolar lavage fluid of mice infected with Bordetella pertussis. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8642645&form=6&db=m Temporal changes in chromatin, intracellular calcium, and poly(ADP-ribose) polymerase during Sindbis virus-induced apoptosis of neuroblastoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8648736&form=6&db=m Efficient retroviral infection of mammalian cells is blocked by inhibition of poly(ADP-ribose) polymerase activity. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8656619&form=6&db=m Production of extracellular virulence factors by Pseudomonas aeruginosa isolates obtained from tracheal, urinary tract, and wound infections. causal interaction,unassigned 3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8825093&form=6&db=m Identification of Salmonella typhi promoters activated by invasion of eukaryotic cells. ongoing research,unassigned 4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9178501&form=6&db=m Induction of apoptosis and cleavage of poly(ADP-ribose) polymerase by cytopathic bovine viral diarrhea virus infection. causal interaction,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9268166&form=6&db=m HIV-1 coreceptor activity of CCR5 and its inhibition by chemokines: independence from G protein signaling and importance of coreceptor downmodulation. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9286049&form=6&db=m Acellular pertussis vaccine in children with perinatal human immunodeficiency virus-type 1 infection. ongoing research,unassigned 2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9302017&form=6&db=m ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury. causal interaction,unassigned 4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9521133&form=6&db=m Evaluation of an immunoglobulin G enzyme-linked immunosorbent assay for pertussis toxin and filamentous hemagglutinin in diagnosis of pertussis in Senegal. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9557631&form=6&db=m Activation of caspases in pig kidney cells infected with wild-type and CrmA/SPI-2 mutants of cowpox and rabbitpox viruses. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9581784&form=6&db=m Inhibition of ICE-like proteases inhibits apoptosis and increases virus production during adenovirus infection. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9607064&form=6&db=m The efficacy of a whole cell pertussis vaccine and fimbriae against Bordetella pertussis and Bordetella parapertussis infections in a respiratory mouse model. therapeutic application,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9696873&form=6&db=m Caspase activation and specific cleavage of substrates after coxsackievirus B3-induced cytopathic effect in HeLa cells. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9755264&form=6&db=m The effect of investigator compliance (observer bias) on calculated efficacy in a pertussis vaccine trial. ongoing research,unassigned 4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10064216&form=6&db=m Incidence of pertussis infection in healthcare workers. diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10079202&form=6&db=m Human immunodeficiency virus-1 infection requires pertussis toxin sensitive G-protein-coupled signalling and mediates cAMP downregulation. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10223692&form=6&db=m Cell-mediated immune responses to antigens of Bordetella pertussis and protection against pertussis in school children. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10456907&form=6&db=m Pseudomonas aeruginosa exoenzyme S stimulates murine lymphocyte proliferation in vitro. causal interaction,unassigned 3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10582188&form=6&db=m Pseudomonas aeruginosa strains obtained from patients with tracheal, urinary tract and wound infection: variations in virulence factors and virulence genes. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10583963&form=6&db=m Use of chemokine receptors by poxviruses. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10618063&form=6&db=m Polymorphism in the pertussis toxin promoter region affecting the DNA-based diagnosis of Bordetella infection. causal interaction,diagnostic usage,unassigned 2,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10639408&form=6&db=m Genital antibody responses in mice after intranasal infection with an attenuated candidate vector strain of Bordetella pertussis. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10655388&form=6&db=m Specificity and sensitivity of high levels of immunoglobulin G antibodies against pertussis toxin in a single serum sample for diagnosis of infection with Bordetella pertussis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10803255&form=6&db=m [Humoral reaction to Bordetella pertussis antigens: pertussis toxin, filamentous hemagglutinin and lipopolysaccharide in children with clinical symptoms of whooping cough. I. Antibody level for B pertussis antigens in children without respiratory tract infection symptoms] causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10918444&form=6&db=m Induction of apoptosis in p16INK4A mutant cell lines by adenovirus-mediated overexpression of p16INK4A protein. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10979896&form=6&db=m Pertussis toxin sensitization alters the pathogenesis of subsequent respiratory syncytial virus infection. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11248084&form=6&db=m Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11423906&form=6&db=m Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11553541&form=6&db=m Role of ADP-ribosyltransferase activity of pertussis toxin in toxin-adhesin redundancy with filamentous hemagglutinin during Bordetella pertussis infection. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11682609&form=6&db=m Inhibition of host cell apoptosis by Toxoplasma gondii is accompanied by reduced activation of the caspase cascade and alterations of poly(ADP-ribose) polymerase expression. diagnostic usage,unassigned 2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11687577&form=6&db=m Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11731642&form=6&db=m Immunologic and epidemiologic experience of vaccination with a monocomponent pertussis toxoid vaccine. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11786979&form=6&db=m Increase in de novo HBV DNA integrations in response to oxidative DNA damage or inhibition of poly(ADP-ribosyl)ation. causal interaction,unassigned 3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11818163&form=6&db=m Efficacy of pertussis components in an acellular vaccine, as assessed in a murine model of respiratory infection and a murine intracerebral challenge model. ongoing research,unassigned 4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11914609&form=6&db=m Apoptosis of human retina and retinal pigment cells induced by human cytomegalovirus infection. ongoing research,unassigned 3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11960384&form=6&db=m Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12068000&form=6&db=m Insulin-like growth factor binding protein-3 inhibits the growth of non-small cell lung cancer. ongoing research,unassigned 2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12082626&form=6&db=m Chromatin remodeling factor encoded by ini1 induces G1 arrest and apoptosis in ini1-deficient cells. diagnostic usage,unassigned 3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12102657&form=6&db=m Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12164482&form=6&db=m Modulating poly (ADP-ribose) polymerase activity: potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress. causal interaction,unassigned 4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12220988&form=6&db=m Bordetella pertussis infection of human respiratory epithelial cells up-regulates intercellular adhesion molecule-1 expression: role of filamentous hemagglutinin and pertussis toxin. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12359428&form=6&db=m Caspase-mediated cleavage of adenovirus early region 1A proteins. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12414932&form=6&db=m Poly(ADP-ribose) polymerase 1 is not strictly required for infection of murine cells by retroviruses. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12558330&form=6&db=m Kinetics of the IgG antibody response to pertussis toxin after infection with B. pertussis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12663756&form=6&db=m Constitutive inositol phosphate formation in cytomegalovirus-infected human fibroblasts is due to expression of the chemokine receptor homologue pUS28. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12692289&form=6&db=m Caspase-mediated cleavage of the feline calicivirus capsid protein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12706678&form=6&db=m Analogous IgG subclass response to pertussis toxin in vaccinated children, healthy or affected by whooping cough. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12714254&form=6&db=m Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14573656&form=6&db=m Pertussis toxin plays an early role in respiratory tract colonization by Bordetella pertussis. causal interaction,ongoing research,unassigned 2,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14575775&form=6&db=m DNA vaccine encoding pertussis toxin S1 subunit induces protection against Bordetella pertussis in mice. therapeutic application,unassigned 3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15003661&form=6&db=m Sero-epidemiology of Bordetella pertussis in England and Wales. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15082117&form=6&db=m Is rheumatoid arthritis a consequence of natural selection for enhanced tuberculosis resistance? causal interaction,unassigned 4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15109724&form=6&db=m ADP-ribosylation by exoenzyme T of Pseudomonas aeruginosa induces an irreversible effect on the host cell cytoskeleton in vivo. ongoing research,unassigned 3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15125661&form=6&db=m Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15155640&form=6&db=m Suppression of serum antibody responses by pertussis toxin after respiratory tract colonization by Bordetella pertussis and identification of an immunodominant lipoprotein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15207713&form=6&db=m Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression. causal interaction,diagnostic usage,unassigned 3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15474504&form=6&db=m Genetic and pharmacological inhibition of poly(ADP-ribose) polymerase-1 interferes in the chlamydial life cycle. ongoing research,unassigned 4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15483239&form=6&db=m Tula hantavirus infection of Vero E6 cells induces apoptosis involving caspase 8 activation. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15521050&form=6&db=m Gene transfer of constitutively active caspase-3 induces apoptosis in a human hepatoma cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15525690&form=6&db=m Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15593007&form=6&db=m The diphtheria and pertussis components of diphtheria-tetanus toxoids-pertussis vaccine should be genetically inactivated mutant toxins. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15709017&form=6&db=m DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15724723&form=6&db=m The seroepidemiology of Bordetella pertussis infection in Western Europe. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15845471&form=6&db=m Pertussis toxin and adenylate cyclase toxin provide a one-two punch for establishment of Bordetella pertussis infection of the respiratory tract. causal interaction,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15895395&form=6&db=m Poly(ADP-ribose)polymerase activity is reduced in circulating mononuclear cells from type 2 diabetic patients. causal interaction,ongoing research,unassigned 4,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16050521&form=6&db=m Age-specific long-term course of IgG antibodies to pertussis toxin after symptomatic infection with Bordetella pertussis. diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16172105&form=6&db=m Serotonin and melatonin, neurohormones for homeostasis, as novel inhibitors of infections by the intracellular parasite chlamydia. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16181138&form=6&db=m Poly(ADP-ribose)polymerase inhibition - where now? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16323142&form=6&db=m Chlamydia pneumoniae alters mildly oxidized low-density lipoprotein-induced cell death in human endothelial cells, leading to necrosis rather than apoptosis. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16352342&form=6&db=m The incidence of Bordetella pertussis infections estimated in the population from a combination of serological surveys. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16622017&form=6&db=m Loss of dendritic cell migration and impaired resistance to Leishmania donovani infection in mice deficient in CCL19 and CCL21. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16638808&form=6&db=m Toxoplasma gondii triggers Gi-dependent PI 3-kinase signaling required for inhibition of host cell apoptosis. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16791011&form=6&db=m The efficiency of R5 HIV-1 infection is determined by CD4 T-cell surface CCR5 density through G alpha i-protein signalling. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16861905&form=6&db=m Adenovirus-Mediated Gene Transfer of FKHRL1 Triple Mutant Efficiently Induces Apoptosis in Melanoma Cells. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17008933&form=6&db=m Potent antitumor efficacy of XAF1 delivered by conditionally replicative adenovirus vector via caspase-independent apoptosis. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17083039&form=6&db=m Pertussis toxin and its binding unit inhibit HIV-1 infection of human cervical tissue and macrophages involving a CD14 pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17202209&form=6&db=m Human cytomegalovirus UL38 protein blocks apoptosis. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17242062&form=6&db=m Pertussis toxin targets airway macrophages to promote Bordetella pertussis infection of the respiratory tract. causal interaction,unassigned 2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17301139&form=6&db=m Bax is activated during rotavirus-induced apoptosis through the mitochondrial pathway. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17376555&form=6&db=m Activation of cell signaling pathways is dependant on the biotype of bovine viral diarrhea viruses type 2. therapeutic application,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17517067&form=6&db=m Rac1, RhoA, and Cdc42 participate in HeLa cell invasion by group B streptococcus. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17599056&form=6&db=m MMP-2 siRNA induced Fas/CD95-mediated extrinsic II apoptotic pathway in the A549 lung adenocarcinoma cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17682703&form=6&db=m [A field survey carried out on the confirmation of a pertussis case in a village of Kirikkale Province, Turkey] diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17721375&form=6&db=m Impact of a pertussis booster vaccination program in adolescents and adults on the epidemiology of pertussis in Austria. diagnostic usage,unassigned 4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17913816&form=6&db=m NSm protein of Rift Valley fever virus suppresses virus-induced apoptosis. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17931416&form=6&db=m Inhibition of Poly(ADP-ribose)polymerase impairs Epstein Barr Virus lytic cycle progression. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17955442&form=6&db=m Delayed role of tumor necrosis factor- alpha in overcoming the effects of pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17962448&form=6&db=m Nuclear Translocation of NF-{kappa}B Precedes Apoptotic Poly(ADP-ribose) Polymerase Cleavage during Productive HSV-1 Replication in Corneal Epithelial Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17991734&form=6&db=m Blockade of tumor growth due to matrix metalloproteinase-9 inhibition is mediated by sequential activation of beta1-integrin, ERK, and NF-kappaB. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18035015&form=6&db=m [Preliminary results in the use of a new composite prosthesis in incisional hernia repair] causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18057239&form=6&db=m Hippocampal poly(ADP-Ribose) polymerase 1 and caspase 3 activation in neonatal bornavirus infection. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18065664&form=6&db=m Parenteral immunization of mice with a genetically inactivated pertussis toxin DNA vaccine induces cell-mediated immunity and protection. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18396434&form=6&db=m Transient inhibition of poly(ADP-ribose) polymerase expression and activity by Toxoplasma gondii is dispensable for parasite-mediated blockade of host cell apoptosis and intracellular parasite replication. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18570592&form=6&db=m Expression of cytotoxicity-associated genes in Marek's disease virus-infected chickens. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18716896&form=6&db=m PARP-1 Val762Ala polymorphism, CagA(+) H. pylori infection and risk for gastric cancer in Han Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18765723&form=6&db=m Pertussis toxin inhibits early chemokine production to delay neutrophil recruitment in response to Bordetella pertussis respiratory tract infection in mice. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19103765&form=6&db=m Role of neutrophils in response to Bordetella pertussis infection in mice. causal interaction,unassigned 3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19109397&form=6&db=m Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19501422&form=6&db=m Functional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19515826&form=6&db=m Interaction of Sindbis virus non-structural protein 3 with poly(ADP-ribose) polymerase 1 in neuronal cells. therapeutic application,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19725791&form=6&db=m Seroprevalence of Bordetella pertussis infection during pregnancy measured by IgG antibodies against pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19759900&form=6&db=m Pertussis toxin stimulates IL-17 production in response to Bordetella pertussis infection in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19846041&form=6&db=m Apoptosis induction in BEFV-infected Vero and MDBK cells through Src-dependent JNK activation regulates caspase-3 and mitochondria pathways. diagnostic usage,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19897724&form=6&db=m Activation of the abundant nuclear factor poly(ADP-ribose) polymerase-1 by Helicobacter pylori. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19899804&form=6&db=m Characterization of a key neutralizing epitope on pertussis toxin recognized by monoclonal antibody 1B7. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20089643&form=6&db=m Simian virus 40 infection triggers a balanced network that includes apoptotic, survival, and stress pathways. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20120949&form=6&db=m [The frequency of detection of IgA, IgG and IgM antibodies to pertussis toxin in patients with respiratory tract infections in Poland] causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20226250&form=6&db=m The seroepidemiology of Bordetella pertussis in Israel--Estimate of incidence of infection. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20508003&form=6&db=m Antibody responses to pertussis toxin display different kinetics after clinical Bordetella pertussis infection than after vaccination with an acellular pertussis vaccine. therapeutic application,unassigned 3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20974829&form=6&db=m IL-1R signaling is required to overcome the effects of pertussis toxin and for efficient infection or vaccination induced immunity against Bordetella pertussis. therapeutic application,unassigned 2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21115396&form=6&db=m Pertussis toxin permeabilization enhances the traversal of Escherichia coli K1, macrophages, and monocytes in a cerebral endothelial barrier model in vitro. ongoing research,unassigned 2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21152071&form=6&db=m Seroprevalence of pertussis in The Netherlands: evidence for increased circulation of Bordetella pertussis. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21276153&form=6&db=m No associations of polymorphisms in ADPRT with hepatitis B virus clearance and hepatocellular carcinoma occurrence in a Korean population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21326346&form=6&db=m Apoptosis-inducing factor contributes to epithelial cell apoptosis induced by enteropathogenic Escherichia coli. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21508166&form=6&db=m Antibodies recognizing protective pertussis toxin epitopes are preferentially elicited by natural infection versus acellular immunization. therapeutic application,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21533103&form=6&db=m Bordetella pertussis infection exacerbates influenza virus infection through pertussis toxin-mediated suppression of innate immunity. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22221038&form=6&db=m PARP1 Polymorphisms Increase the Risk of Gastric Cancer in a Chinese Population. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22243639&form=6&db=m The seroepidemiology of pertussis in NSW: fluctuating immunity profiles related to changes in vaccination schedules. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22303462&form=6&db=m Coxiella burnetii induces apoptosis during early stage infection via a caspase-independent pathway in human monocytic THP-1 cells. causal interaction,unassigned 2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22527330&form=6&db=m Bordetella Pertussis Toxin does not induce the release of pro-inflammatory cytokines in human whole blood. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22558249&form=6&db=m Increased population prevalence of low pertussis toxin antibody levels in young children preceding a record pertussis epidemic in Australia. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22623791&form=6&db=m Herpes simplex virus 1 infection activates poly(ADP-ribose) polymerase and triggers the degradation of poly(ADP-ribose) glycohydrolase. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22675572&form=6&db=m Hepatitis C virus induced a novel apoptosis-like death of pancreatic beta cells through a caspase 3-dependent pathway. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22689823&form=6&db=m Examining the Role of Actin-Plasma Membrane Association in Pseudomonas aeruginosa Infection and Type III Secretion Translocation in Migratory T24 Epithelial Cells. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22787194&form=6&db=m Two-Component Cluster Analysis of a Large Serodiagnostic Database for Specificity of Increases of IgG Antibodies against Pertussis Toxin in Paired Serum Samples and of Absolute Values in Single Serum Samples. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22896603&form=6&db=m U20 Is Responsible for Human Herpesvirus 6B Inhibition of TNF Receptor-Dependent Signaling and Apoptosis. therapeutic application,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22921807&form=6&db=m RGS2 overexpression or G(i) inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cells. therapeutic application,unassigned 3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22981763&form=6&db=m Differences in avidity of IgG antibodies to pertussis toxin after acellular pertussis booster vaccination and natural infection. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23027529&form=6&db=m Pertussis toxin exacerbates and prolongs airway inflammatory responses during Bordetella pertussis infection. causal interaction,unassigned 4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23049934&form=6&db=m Inhibition of poly(ADP-ribose) polymerase interferes with Trypanosoma cruzi infection and proliferation of the parasite. therapeutic application,unassigned 2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23255787&form=6&db=m Poly(ADP-ribose) polymerase 1 promotes transcriptional repression of integrated retroviruses. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23333591&form=6&db=m Involvement of PI 3 kinase/Akt-dependent Bad phosphorylation in Toxoplasma gondii-mediated inhibition of host cell apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23503473&form=6&db=m Tumor suppressor in lung cancer-1 (TSLC1) mediated by dual-regulated oncolytic adenovirus exerts specific antitumor actions in a mouse model. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24308586&form=6&db=m Clustered cases of Bordetella pertussis infection cause high levels of IgG antibodies against pertussis toxin in adolescents in Gaobeidian city, China. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24391789&form=6&db=m Loss of multi-epitope specificity in memory CD4(+) T cell responses to B. Pertussis with age. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24768867&form=6&db=m Modeling rates of infection with transient maternal antibodies and waning active immunity: application to Bordetella pertussis in Sweden. therapeutic application,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24918927&form=6&db=m RIG-I enhanced interferon independent apoptosis upon Junin virus infection. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24927176&form=6&db=m TRAIL enhances apoptosis of human hepatocellular carcinoma cells sensitized by hepatitis C virus infection: therapeutic implications. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24980821&form=6&db=m Tumor suppressor XAF1 induces apoptosis, inhibits angiogenesis and inhibits tumor growth in hepatocellular carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25069981&form=6&db=m Epithelial anion transporter pendrin contributes to inflammatory lung pathology in mouse models of Bordetella pertussis infection. ongoing research,unassigned 2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25093282&form=6&db=m Seroprevalence of IgG antibodies to pertussis toxin in children and adolescents in Estonia. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25139258&form=6&db=m PARP inhibitor olaparib increases the oncolytic activity of dl922-947 in in vitro and in vivo model of anaplastic thyroid carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25481756&form=6&db=m Crimean-Congo haemorrhagic fever replication interplays with regulation mechanisms of apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26090668&form=6&db=m The Role of ExoS in Dissemination of Pseudomonas aeruginosa during Pneumonia. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26277068&form=6&db=m Estimated and reported incidence of pertussis in Estonian adults: A seroepidemiological study. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26379653&form=6&db=m The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26412843&form=6&db=m Prevalence, diagnosis, and disease course of pertussis in adults with acute cough: a prospective, observational study in primary care. diagnostic usage,unassigned 4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26880103&form=6&db=m Porcine parvovirus infection activates mitochondria-mediated apoptotic signaling pathway by inducing ROS accumulation. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26920733&form=6&db=m Selenium Plays a Protective Role in Staphylococcus aureus-Induced Endometritis in the Uterine Tissue of Rats. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27028089&form=6&db=m Poly (ADP-ribose) polymerase-1 silences retroviruses independently of viral DNA integration or heterochromatin formation. therapeutic application,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27609461&form=6&db=m Pertussis Leukocytosis: Mechanisms, Clinical Relevance and Treatment. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27637347&form=6&db=m The growth of arthralgic Ross River virus is restricted in human monocytic cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27895737&form=6&db=m High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28213497&form=6&db=m Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response. causal interaction,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28646697&form=6&db=m Seroepidemiology of whooping cough in the Czech Republic: estimates of incidence of infection in adults. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28928726&form=6&db=m Phosphoprotein Gene Contributes to the Enhanced Apoptosis Induced by Wild-Type Rabies Virus GD-SH-01 In Vitro. causal interaction,unassigned 4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28981630&form=6&db=m The JAK/STAT3 signaling pathway mediates inhibition of host cell apoptosis by Chlamydia psittaci infection. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28988534&form=6&db=m Biochemical Variations in Cytolytic Activity of Ortho- and Paramyxoviruses in Human Lung Tumor Cell Culture. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29037576&form=6&db=m Pertussis seroepidemiology in women and their infants in Sarlahi District, Nepal. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29046226&form=6&db=m Pertussis toxin IgA testing over-diagnoses recent pertussis infection. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29164393&form=6&db=m Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29183555&form=6&db=m Enhanced diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29207339&form=6&db=m Structure-activity relationships for inhibitors of Pseudomonas aeruginosa exoenzyme S ADP-ribosyltransferase activity. ongoing research,unassigned 3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29408190&form=6&db=m Seroepidemiology of diphtheria and pertussis in Chongqing, China: serology-based evidence of Bordetella pertussis infection. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29501586&form=6&db=m PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29581192&form=6&db=m Characterization of individual human antibodies binding pertussis toxin stimulated by acellular immunization. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30021550&form=6&db=m Recombinant oncolytic Newcastle disease virus displays antitumor activities in anaplastic thyroid cancer cells. therapeutic application,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30038627&form=6&db=m In Vivo Blockade of Murine ARTC2.2 During Cell Preparation Preserves the Vitality and Function of Liver Tissue-Resident Memory T Cells. ongoing research,unassigned 4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30078582&form=6&db=m Assessment of Poly(ADP-ribose) Polymerase1 (PARP1) expression and activity in cells purified from blood and milk of dairy cattle. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30322911&form=6&db=m ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30642317&form=6&db=m Acute exacerbation of idiopathic pulmonary fibrosis induced by pertussis: the first case report. diagnostic usage,unassigned 3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31015836&form=6&db=m Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31099182&form=6&db=m Host relieves lnc-IRAK3-3-sequestered miR-891b to attenuate apoptosis in Enterovirus 71 infection. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31174925&form=6&db=m PARP1: A potential biomarker for gastric cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31217354&form=6&db=m PARP-1 controls NK cell recruitment to the site of viral infection. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31299194&form=6&db=m Conflicting effects of poly(ADP-ribose) polymerase inhibitor on cell-mediated and virion-mediated HTLV-1 infection. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31315986&form=6&db=m An Interaction with PARP-1 and Inhibition of Parylation Contribute to Attenuation of DNA Damage Signaling by the Adenovirus E4orf4 Protein. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31376138&form=6&db=m Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31610300&form=6&db=m Assessment of IgA anti-PT and IgG anti-ACT reflex testing to improve Bordetella pertussis serodiagnosis in recently vaccinated subjects. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31670405&form=6&db=m Parthanatos-associated proteins are stimulated intraocularly during development of experimental murine cytomegalovirus retinitis in mice with retrovirus-induced immunosuppression. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31694960&form=6&db=m Murine Coronavirus Infection Activates the Aryl Hydrocarbon Receptor in an Indoleamine 2,3-Dioxygenase-Independent Manner, Contributing to Cytokine Modulation and Proviral TCDD-Inducible-PARP Expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31731820&form=6&db=m Trends in Hospital Admissions for Pertussis Infection: A Nationwide Retrospective Observational Study in Italy, 2002-2016. diagnostic usage,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31915279&form=6&db=m PARP1 Enhances Influenza A Virus Propagation by Facilitating Degradation of Host Type I Interferon Receptor. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31945121&form=6&db=m Evaluation of inactivated Bordetella pertussis as a delivery system for the immunization of mice with Pneumococcal Surface Antigen A. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32753633&form=6&db=m Porcine reproductive and respiratory syndrome virus infection induces endoplasmic reticulum stress, facilitates virus replication, and contributes to autophagy and apoptosis. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32765879&form=6&db=m Differences in epitope-specific antibodies to pertussis toxin after infection and acellular vaccinations. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32788029&form=6&db=m [Progress of nicotinamide in preventing infection and sepsis]. causal interaction,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33012025&form=6&db=m Parents of ataxia-telangiectasia patients display a distinct cellular immune phenotype mimicking ATM mutated patients. causal interaction,unassigned 3,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33051211&form=6&db=m Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity. therapeutic application,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33172999&form=6&db=m Trypanosoma cruzi Induces the PARP1/AP-1 Pathway for Upregulation of Metalloproteinases and Transforming Growth Factor ? in Macrophages: Role in Cardiac Fibroblast Differentiation and Fibrosis in Chagas Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33202171&form=6&db=m Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential. therapeutic application,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33357705&form=6&db=m Comparative analysis of key immune protection factors in H9N2 avian influenza viruses infected and immunized specific pathogen-free chicken. therapeutic application,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33361772&form=6&db=m Schistosoma mansoni eggs induce Wnt/?-catenin signaling and activate the protooncogene c-Jun in human and hamster colon. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33476693&form=6&db=m Repurposing of antiparasitic niclosamide to inhibit respiratory syncytial virus (RSV) replication. therapeutic application,unassigned 1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33526003&form=6&db=m Flavonol morin targets host ACE2, IMP-?, PARP-1 and viral proteins of SARS-CoV-2, SARS-CoV and MERS-CoV critical for infection and survival: a computational analysis. unassigned - 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33678454&form=6&db=m Determination of serum neutralizing antibodies reveals important difference in quality of antibodies against pertussis toxin in children after infection. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33775041&form=6&db=m [Synergistic Effect of NF-?B Signaling Pathway Inhibitor and Oncolytic ?Measles Virus Vaccine Strain against Lung Cancer and Underlying Mechanisms]. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33803196&form=6&db=m New Insights into the Significance of PARP-1 Activation: Flow Cytometric Detection of Poly(ADP-Ribose) as a Marker of Bovine Intramammary Infection. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34037418&form=6&db=m Inhibition of PARP1 Dampens Pseudorabies Virus Infection through DNA Damage-Induced Antiviral Innate Immunity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34145457&form=6&db=m Pertussis toxin promotes pulmonary hypertension in an infant mouse model of Bordetella pertussis infection. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34479416&form=6&db=m Prognostic Performance of Peripheral Blood Biomarkers in Identifying Seropositive Individuals at Risk of Developing Clinically Symptomatic Chagas Cardiomyopathy. diagnostic usage,unassigned 3,0 2.4.2.30 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19264700&form=6&db=m Disruption of Poly(ADP-Ribose) Homeostasis Affects Spermiogenesis and Sperm Chromatin Integrity in Mice. causal interaction,unassigned 4,0 2.4.2.30 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31174020&form=6&db=m Doxorubicin-induced testicular damage is related to PARP-1 signaling molecules in mice. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Infertility, Male http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23885303&form=6&db=m Role of poly(ADP-ribose) polymerases in male reproduction. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Infertility, Male http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25106941&form=6&db=m Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Infertility, Male http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25673562&form=6&db=m Spermatid Head Elongation with Normal Nuclear Shaping Requires ADP-Ribosyltransferase PARP11 (ARTD11) in Mice. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12123754&form=6&db=m GPI 6150, a PARP inhibitor, reduces the colon injury caused by dinitrobenzene sulfonic acid in the rat. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12782201&form=6&db=m Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15554929&form=6&db=m Activator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Inflammatory Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31413177&form=6&db=m PARP1 Inhibition Radiosensitizes Models of Inflammatory Breast Cancer to Ionizing Radiation. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Influenza in Birds http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28988534&form=6&db=m Biochemical Variations in Cytolytic Activity of Ortho- and Paramyxoviruses in Human Lung Tumor Cell Culture. unassigned - 2.4.2.30 Influenza in Birds http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31015836&form=6&db=m Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7856288&form=6&db=m Enhancing effects of pertussis toxin B oligomer on the immunogenicity of influenza vaccine administered intranasally. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10493334&form=6&db=m Safety and immunogenicity of heptavalent pneumococcal CRM197 conjugate vaccine in infants and toddlers. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,2 2.4.2.30 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12557009&form=6&db=m Apoptosis and microglial activation in influenza encephalopathy. unassigned - 2.4.2.30 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21533103&form=6&db=m Bordetella pertussis infection exacerbates influenza virus infection through pertussis toxin-mediated suppression of innate immunity. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26504237&form=6&db=m Battle between influenza A virus and a newly identified antiviral activity of the PARP-containing ZAPL protein. unassigned - 2.4.2.30 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27807230&form=6&db=m The Short Form of the Zinc Finger Antiviral Protein Inhibits Influenza A Virus Protein Expression and Is Antagonized by the Virus-Encoded NS1. causal interaction,unassigned 1,0 2.4.2.30 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30988430&form=6&db=m ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase ?-TrCP. therapeutic application,unassigned 1,0 2.4.2.30 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31015836&form=6&db=m Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31915279&form=6&db=m PARP1 Enhances Influenza A Virus Propagation by Facilitating Degradation of Host Type I Interferon Receptor. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16981139&form=6&db=m Oxidative Stress in Young Zucker Rats with Impaired Glucose Tolerance is Diminished by Acarbose. causal interaction,unassigned 4,0 2.4.2.30 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20338998&form=6&db=m PARP-1 DEFICIENCY EXACERBATES DIET-INDUCED OBESITY IN MICE. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21447485&form=6&db=m Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance. therapeutic application,unassigned 2,0 2.4.2.30 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25536389&form=6&db=m Effect of NAD on PARP-mediated insulin sensitivity in oleic acid treated hepatocytes. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25603556&form=6&db=m Palmitate activation by fatty acid transport protein 4 as a model system for hepatocellular apoptosis and steatosis. unassigned - 2.4.2.30 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28224182&form=6&db=m PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2565041&form=6&db=m Regulation of ATP-sensitive K+ channels in insulinoma cells: activation by somatostatin and protein kinase C and the role of cAMP. ongoing research,unassigned 1,0 2.4.2.30 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2904889&form=6&db=m Somatostatin activates glibenclamide-sensitive and ATP-regulated K+ channels in insulinoma cells via a G-protein. causal interaction,unassigned 1,0 2.4.2.30 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9322797&form=6&db=m Effects of alpha 2-adrenergic agonism, imidazolines, and G-protein on insulin secretion in beta cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11078451&form=6&db=m Poly(ADP-ribose) polymerase facilitates the repair of N-methylpurines in mitochondrial DNA. ongoing research,unassigned 4,0 2.4.2.30 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11463841&form=6&db=m Increased susceptibility to streptozotocin-induced beta-cell apoptosis and delayed autoimmune diabetes in alkylpurine-DNA-N-glycosylase-deficient mice. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20176078&form=6&db=m Role of JNK activation in pancreatic beta-cell death by streptozotocin. therapeutic application,unassigned 2,0 2.4.2.30 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29499409&form=6&db=m Liquiritigenin prevents palmitate-induced beta-cell apoptosis via estrogen receptor-mediated AKT activation. causal interaction,unassigned 3,0 2.4.2.30 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31285389&form=6&db=m Tension induces intervertebral disc degeneration via endoplasmic reticulum stress-mediated autophagy. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Intestinal Polyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15940627&form=6&db=m Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.4.2.30 Iron Overload http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29890135&form=6&db=m Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. causal interaction,unassigned 1,0 2.4.2.30 Iron Overload http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30177808&form=6&db=m Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload. ongoing research,unassigned 4,0 2.4.2.30 Ischemic Attack, Transient http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9390645&form=6&db=m Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ischemic Attack, Transient http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10987849&form=6&db=m Effect of transient focal ischemia of mouse brain on energy state and NAD levels: no evidence that NAD depletion plays a major role in secondary disturbances of energy metabolism. causal interaction,unassigned 4,0 2.4.2.30 Ischemic Attack, Transient http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12750003&form=6&db=m Role of superoxide in poly(ADP-ribose) polymerase upregulation after transient cerebral ischemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,4 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10350529&form=6&db=m Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15355313&form=6&db=m The effect of PARP inhibitor on ischaemic cell death, its related inflammation and survival signals. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15514191&form=6&db=m Interaction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15519361&form=6&db=m Neuroprotective effects of ONO-1924H, an inhibitor of poly ADP-ribose polymerase (PARP), on cytotoxicity of PC12 cells and ischemic cerebral damage. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16085349&form=6&db=m Effect of 3-aminobenzamide, PARP inhibitor, on matrix metalloproteinase-9 level in plasma and brain of ischemic stroke model. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19258025&form=6&db=m The early immunological response to acute ischemic stroke: Differential gene expression in subpopulations of mononuclear cells. diagnostic usage,unassigned 3,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19288225&form=6&db=m Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20427721&form=6&db=m Endonuclease G does not play an obligatory role in poly(ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21409386&form=6&db=m Anti-inflammatory mechanism of taurine against ischemic stroke is related to down-regulation of PARP and NF-?B. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21741620&form=6&db=m MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor, ameliorates ischemic brain damage in a non-human primate model. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21807360&form=6&db=m Climbing STAIRs towards clinical trials with a novel PARP-1 inhibitor for the treatment of ischemic stroke. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22436003&form=6&db=m Combined therapy with PJ34, a poly(ADP-ribose)polymerase inhibitor, reduces tissue plasminogen activator-induced hemorrhagic transformations in cerebral ischemia in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23463404&form=6&db=m Ginsenoside Rd blocks AIF mitochondrio-nuclear translocation and NF-?B nuclear accumulation by inhibiting poly(ADP-ribose) polymerase-1 after focal cerebral ischemia in rats. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25868125&form=6&db=m Chromosomal damage and micronucleus induction by MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor: Evidence for a non-DNA-reactive mode of action. therapeutic application,unassigned 4,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26365274&form=6&db=m Pertussis toxin reduces calcium influx to protect ischemic stroke in a middle cerebral artery occlusion model. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27663279&form=6&db=m Poly(ADP-ribose) polymerase is not involved in the neuroprotection exerted by azithromycin against ischemic stroke in mice. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28370165&form=6&db=m Neuroprotective effects of a novel Poly (ADP-Ribose) Polymerase-1 inhibitor, JPI-289, in hypoxic rat cortical neurons. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29383691&form=6&db=m Early Treatment with Poly(ADP-Ribose) Polymerase-1 Inhibitor (JPI-289) Reduces Infarct Volume and Improves Long-Term Behavior in an Animal Model of Ischemic Stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29709770&form=6&db=m Regulatory T cells increase after treatment with poly (ADP-ribose) polymerase-1 inhibitor in ischemic stroke patients. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29938598&form=6&db=m Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke. unassigned - 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30260276&form=6&db=m Polymorphism of PARP-1 indicates an increased risk and a worse initial severity of ischemic stroke. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31683401&form=6&db=m [Gender-specific factors of ischemic stroke among atrial fibrillation patients]. unassigned - 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32317937&form=6&db=m Delayed PARP-1 Inhibition Alleviates Post-stroke Inflammation in Male Versus Female Mice: Differences and Similarities. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32338336&form=6&db=m Baicalein attenuates caspase-independent cells death via inhibiting PARP-1 activation and AIF nuclear translocation in cerebral ischemia/reperfusion rats. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32676009&form=6&db=m Pertussis Toxin Ameliorates Microglial Activation Associated With Ischemic Stroke. causal interaction,ongoing research,unassigned 4,3,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32801651&form=6&db=m First-in-Human Evaluation of the Safety, Tolerability, and Pharmacokinetics of a Neuroprotective Poly (ADP-ribose) Polymerase-1 Inhibitor, JPI-289, in Healthy Volunteers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34115723&form=6&db=m Repurposing of Clinically Approved Poly-(Adp-Ribose) Polymerase Inhibitors For The Therapy of Sepsis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34241907&form=6&db=m Emerging role of PARP-1 and PARthanatos in ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34341068&form=6&db=m Pertussis toxin-induced inflammatory response exacerbates intracerebral haemorrhage and ischaemic stroke in mice. ongoing research,unassigned 3,0 2.4.2.30 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34445832&form=6&db=m [The epidemiological characteristics and adherence to hypoglycemic agents of ischemic stroke patients with diabetes]. causal interaction,unassigned 2,0 2.4.2.30 Joint Instability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24780630&form=6&db=m Genotype-phenotype relationship in a child with 2.3 Mb de novo interstitial 12p13.33-p13.32 deletion. causal interaction,unassigned 1,0 2.4.2.30 Keloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27565798&form=6&db=m A Selenium-Enriched Ziyang Green Tea Polysaccharide Induces Bax-Dependent Mitochondrial Apoptosis and Inhibits TGF-?1-Stimulated Collagen Expression in Human Keloid Fibroblasts via NG2 Inactivation. therapeutic application,unassigned 1,0 2.4.2.30 Keloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31119062&form=6&db=m PARP1 Inhibition as a Novel Therapeutic Target for Keloid Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 2.4.2.30 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3629615&form=6&db=m Pertussis toxin induces fatty liver, hyperlipemia and ketosis in hamsters. unassigned - 2.4.2.30 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19945439&form=6&db=m Poly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11952169&form=6&db=m Accumulation of plasma N-methyl-2-pyridone-5-carboxamide in patients with chronic renal failure. therapeutic application,unassigned 1,0 2.4.2.30 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16604373&form=6&db=m Accumulation of poly(ADP-ribose) polymerase inhibitors in children with chronic renal failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,4 2.4.2.30 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28224182&form=6&db=m PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30867423&form=6&db=m Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19417155&form=6&db=m Development of flexible-heteroarotinoids for kidney cancer. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22172427&form=6&db=m Penta-O-galloyl-?-D-glucose attenuates cisplatin-induced nephrotoxicity via reactive oxygen species reduction in renal epithelial cells and enhances antitumor activity in Caki-2 renal cancer cells. unassigned - 2.4.2.30 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26794413&form=6&db=m MIR494 reduces renal cancer cell survival coinciding with increased lipid droplets and mitochondrial changes. therapeutic application,unassigned 1,0 2.4.2.30 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28346230&form=6&db=m Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29254209&form=6&db=m Long noncoding RNA PVT1 inhibits renal cancer cell apoptosis by up-regulating Mcl-1. causal interaction,diagnostic usage,unassigned 2,4,0 2.4.2.30 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32402770&form=6&db=m Histone-dependent PARP-1 inhibitors: A novel therapeutic modality for the treatment of prostate and renal cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33069804&form=6&db=m Folliculin deficient renal cancer cells exhibit BRCA1 A complex expression impairment and sensitivity to PARP1 inhibitor olaparib. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Labyrinth Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21366505&form=6&db=m High dose combination pertussis toxin induces autoimmune inner ear disease in Sprague-Dawley rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,3 2.4.2.30 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11920651&form=6&db=m Reduced poly(ADP-ribosyl)ation in lymphocytes of laryngeal cancer patients: results of a case-control study. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28868867&form=6&db=m [Apoptosis mechanism of taxol combined with resveratrol on human laryngeal carcinoma Hep-2 cells]. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 2.4.2.30 Leg Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30581533&form=6&db=m Redox Profiling Reveals Clear Differences between Molecular Patterns of Wound Fluids from Acute and Chronic Wounds. unassigned - 2.4.2.30 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14557488&form=6&db=m Enhanced polyadenosine diphosphate-ribosylation in gonadotropin-releasing hormone agonist-treated uterine leiomyoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15572421&form=6&db=m Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.4.2.30 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17652152&form=6&db=m Selective progesterone receptor modulator asoprisnil induces endoplasmic reticulum stress in cultured human uterine leiomyoma cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Leiomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21503594&form=6&db=m Novel approaches to treatment of leiomyosarcomas. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Leiomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32299819&form=6&db=m Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Leiomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33183763&form=6&db=m Homologous recombination repair deficiency as a therapeutic target in sarcoma. therapeutic application,unassigned 4,0 2.4.2.30 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19186178&form=6&db=m Activation of PI3K/Akt signaling has a dominant negative effect on IL-12 production by macrophages infected with Leishmania amazonensis promastigotes. therapeutic application,unassigned 4,0 2.4.2.30 Leprosy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1281276&form=6&db=m Effect of inhibitor of poly (ADP-ribose) polymerase in blood lymphocyte cultures of untreated leprosy patients. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1824251&form=6&db=m Pertussis toxin selectively interferes with the responses of the HL-60 human promyelocytic cell line to dimethylsulfoxide. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1831198&form=6&db=m Characterization of increased K+ permeability associated with the stimulation of receptors for immunoglobulin E on rat basophilic leukemia cells. unassigned - 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2506857&form=6&db=m Pertussis toxin inhibits differentiation induced by retinoic acid in a human promyelocytic leukemia cell line HL-60. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7592844&form=6&db=m Pertussis toxin inhibits phospholipase C activation and Ca2+ mobilization by sphingosylphosphorylcholine and galactosylsphingosine in HL60 leukemia cells. Implications of GTP-binding protein-coupled receptors for lysosphingolipids. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7741762&form=6&db=m Histamine receptor-dependent and/or -independent activation of guanine nucleotide-binding proteins by histamine and 2-substituted histamine derivatives in human leukemia (HL-60) and human erythroleukemia (HEL) cells. ongoing research,unassigned 1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8064231&form=6&db=m Pertussis toxin inhibits activation-induced cell death of human thymocytes, pre-B leukemia cells and monocytes. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8082877&form=6&db=m Augmentation of tumor necrosis factor-alpha-induced monocytic differentiation of a myelomonocytic leukemia (WEHI-3B JCS) by pertussis toxin. ongoing research,unassigned 2,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8605017&form=6&db=m Inhibitors of poly(ADP-ribose) polymerase block nitric oxide-induced apoptosis but not differentiation in human leukemia HL-60 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8627159&form=6&db=m Biochemical pathways of apoptosis: nicotinamide adenine dinucleotide-deficient cells are resistant to tumor necrosis factor or ultraviolet light activation of the 24-kD apoptotic protease and DNA fragmentation. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8788037&form=6&db=m Overexpression of poly(ADP-ribose) polymerase promotes cell cycle arrest and inhibits neutrophilic differentiation of NB4 acute promyelocytic leukemia cells. causal interaction,unassigned 4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9013854&form=6&db=m The interleukin 1beta-converting enzyme inhibitor CrmA prevents Apo1/Fas- but not glucocorticoid-induced poly(ADP-ribose) polymerase cleavage and apoptosis in lymphoblastic leukemia cells. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9228015&form=6&db=m Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9493968&form=6&db=m Characterization of antibodies specific for the caspase cleavage site on poly(ADP-ribose) polymerase: specific detection of apoptotic fragments and mapping of the necrotic fragments of poly(ADP-ribose) polymerase. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9635568&form=6&db=m Apoptosis and perturbation of cell cycle progression in an acidic environment after hyperthermia. unassigned - 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9857092&form=6&db=m Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). therapeutic application,unassigned 1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10913000&form=6&db=m Peroxynitrite-induced apoptosis involves activation of multiple caspases in HL-60 cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11807010&form=6&db=m The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11861382&form=6&db=m WK175, a novel antitumor agent, decreases the intracellular nicotinamide adenine dinucleotide concentration and induces the apoptotic cascade in human leukemia cells. ongoing research,unassigned 3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12036322&form=6&db=m Sequence-specific binding of poly(ADP-ribose) polymerase-1 to the human T cell leukemia virus type-I tax responsive element. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12213287&form=6&db=m Purging effect of dibutyl phthalate on leukemia cells involves fas independent activation of caspase-3/CPP32 protease. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12506112&form=6&db=m Apoptosis in leukemia cells is accompanied by alterations in the levels and localization of nucleolin. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12525876&form=6&db=m Synergistic anticancer action of reversibly and irreversibly acting ligands of poly (ADP-ribose) polymerase. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941430&form=6&db=m The human formyl peptide receptor as model system for constitutively active G-protein-coupled receptors. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15011755&form=6&db=m Inhibition of proteasome activity by various fruits and vegetables is associated with cancer cell death. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15142883&form=6&db=m Apoptotic resistance to ionizing radiation in pediatric B-precursor acute lymphoblastic leukemia frequently involves increased NF-kappaB survival pathway signaling. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252149&form=6&db=m Selenite-induced p53 Ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells. causal interaction,unassigned 1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15369734&form=6&db=m Methylene chloride fraction of Scutellaria barbata induces apoptosis in human U937 leukemia cells via the mitochondrial signaling pathway. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15857606&form=6&db=m Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15875806&form=6&db=m Differential responses of proliferative and non-proliferative leukemia cells to oxidative stress. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16273296&form=6&db=m Interactive effects of histone deacetylase inhibitors and TRAIL on apoptosis in human leukemia cells: involvement of both death receptor and mitochondrial pathways. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16323285&form=6&db=m Down-modulation of poly(ADP-ribose) polymerase-1 (PARP-1) in human TUR leukemia cells restores transcriptional responsiveness for differentiation and cell cycle arrest. ongoing research,unassigned 3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16970926&form=6&db=m Induction of G2/M phase arrest and apoptosis of human leukemia cells by potent antitumor triazoloacridinone C-1305. causal interaction,unassigned 1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16985072&form=6&db=m Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways. causal interaction,ongoing research,unassigned 3,3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17089125&form=6&db=m Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17237268&form=6&db=m Combination treatment with arsenic trioxide and phytosphingosine enhances apoptotic cell death in arsenic trioxide-resistant cancer cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17332322&form=6&db=m Breaking chemoresistance and radioresistance with [213Bi]anti-CD45 antibodies in leukemia cells. causal interaction,unassigned 4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17928930&form=6&db=m Oleanolic Acid Induces Apoptosis in Human Leukemia Cells through Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18342402&form=6&db=m Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines. therapeutic application,unassigned 4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18590313&form=6&db=m Lupane-type triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and the apoptotic effect of 28-hydroxy-3-oxo-lup-20(29)-en-30-al. ongoing research,unassigned 1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18676827&form=6&db=m Methadone, commonly used as maintenance medication for outpatient treatment of opioid dependence, kills leukemia cells and overcomes chemoresistance. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18941120&form=6&db=m Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19671751&form=6&db=m Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20127053&form=6&db=m Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells. unassigned - 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20438329&form=6&db=m beta-Lapachone (LAPA) Decreases Cell Viability and Telomerase Activity in Leukemia Cells: Suppression of Telomerase Activity by LAPA. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,3 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20600805&form=6&db=m Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cells by Inula racemosa. unassigned - 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20704577&form=6&db=m Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs) exert their anti-proliferative activity by interfering with Akt-mTOR signaling and bax:bcl-2 ratio modulation in cells from chronic myeloid leukemic patients. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21165570&form=6&db=m Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells. ongoing research,unassigned 3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21624350&form=6&db=m ALCAPs induce mitochondrial apoptosis and activate DNA damage response by generating ROS and inhibiting topoisomerase I enzyme activity in K562 leukemia cell line. unassigned - 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21760826&form=6&db=m Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways. causal interaction,unassigned 1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21846186&form=6&db=m A112, a tamibarotene dimethylaminoethyl ester, may inhibit human leukemia cell growth more potently than tamibarotene. causal interaction,unassigned 3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22555976&form=6&db=m Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23255787&form=6&db=m Poly(ADP-ribose) polymerase 1 promotes transcriptional repression of integrated retroviruses. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23732481&form=6&db=m Anticancer activity of a synthetic peptide derived from harmoniasin, an antibacterial peptide from the ladybug Harmonia axyridis. ongoing research,unassigned 2,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23813779&form=6&db=m Tanshinone IIA Induces Autophagic Cell Death via Activation of AMPK and ERK and Inhibition of mTOR and p70 S6K in KBM-5 Leukemia Cells. unassigned - 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24692719&form=6&db=m Combinatorial Effects of PARP Inhibitor PJ34 and Histone Deacetylase Inhibitor Vorinostat on Leukemia Cell Lines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25390937&form=6&db=m Eupatorin-induced cell death in human leukemia cells is dependent on caspases and activates the mitogen-activated protein kinase pathway. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25442260&form=6&db=m Synergistic property of cordycepin in cultivated Cordyceps militaris-mediated apoptosis in human leukemia cells. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25667168&form=6&db=m The combination of the PARP inhibitor rucaparib and 5FU is an effective strategy for treating acute leukemias. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25753585&form=6&db=m Apoptotic Effect of Galbanic Acid via Activation of Caspases and Inhibition of Mcl-1 in H460 Non-Small Lung Carcinoma Cells. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25828893&form=6&db=m c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase-Activated Leukemias. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25915523&form=6&db=m Eltrombopag modulates reactive oxygen species and decreases acute myeloid leukemia cell survival. therapeutic application,unassigned 1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26314963&form=6&db=m Inhibition of poly(ADP-ribose) polymerase 1 protects against acute myeloid leukemia by suppressing the myeloproliferative leukemia virus oncogene. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26396258&form=6&db=m Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia. unassigned - 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26440674&form=6&db=m Hyperisampsins H-M, Cytotoxic Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26594843&form=6&db=m Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors. therapeutic application,unassigned 1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26634675&form=6&db=m PARP Inhibitors Suppress AML1-ETO- and PML-RAR?-Positive Leukemia. therapeutic application,unassigned 3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26836964&form=6&db=m Epicochalasines?A and B: Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units from Aspergillus flavipes. causal interaction,unassigned 1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26985944&form=6&db=m Paclitaxel induces apoptosis in leukemia cells through a JNK activation-dependent pathway. ongoing research,unassigned 1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27064363&form=6&db=m Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin. causal interaction,unassigned 1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27342489&form=6&db=m [Gene Expression Profile of Apoptosis in Leukemia Cells Induced by Hsp90 Selective inhibitor 17-AAG]. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27551000&form=6&db=m A Phase I study of topotecan, carboplatin and the PARP inhibitor veliparib in acute leukemias, aggressive myeloproliferative neoplasms and chronic myelomonocytic leukemia. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27644631&form=6&db=m Curcumin Induces Apoptosis in Pre-B Acute Lymphoblastic Leukemia Cell Lines Via PARP-1 Cleavage. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27658482&form=6&db=m Zephycandidine A, the First Naturally Occurring Imidazo[1,2-f]phenanthridine Alkaloid from Zephyranthes candida, Exhibits Significant Anti-tumor and Anti-acetylcholinesterase Activities. causal interaction,unassigned 3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27894958&form=6&db=m Poly (ADP-ribose) polymerase inhibitors selectively induce cytotoxicity in TCF3-HLF-positive leukemic cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28299675&form=6&db=m A Regulatory Role for RUNX1, RUNX3 in the Maintenance of Genomic Integrity. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28383142&form=6&db=m Auraptene Induces Apoptosis via Myeloid Cell Leukemia 1-Mediated Activation of Caspases in PC3 and DU145 Prostate Cancer Cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28481221&form=6&db=m Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28823558&form=6&db=m Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29163182&form=6&db=m The Natural Antiangiogenic Compound AD0157 Induces Caspase-Dependent Apoptosis in Human Myeloid Leukemia Cells. ongoing research,unassigned 1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29296788&form=6&db=m MLL-AF9 leukemias are sensitive to PARP1 inhibitors combined with cytotoxic drugs. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29399146&form=6&db=m Loperamide, an antidiarrheal agent, induces apoptosis and DNA damage in leukemia cells. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29423093&form=6&db=m Combination of a hypomethylating agent and inhibitors of PARP and HDAC traps PARP1 and DNMT1 to chromatin, acetylates DNA repair proteins, down-regulates NuRD and induces apoptosis in human leukemia and lymphoma cells. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29784639&form=6&db=m Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors. causal interaction,diagnostic usage,unassigned 3,3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29903986&form=6&db=m Effect of Notch and PARP Pathways' Inhibition in Leukemic Cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29969371&form=6&db=m Cladribine in combination with entinostat synergistically elicits anti-proliferative/anti-survival effects on multiple myeloma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29990873&form=6&db=m A novel synthesized 3', 5'-diprenylated chalcone mediates the proliferation of human leukemia cells by regulating apoptosis and autophagy pathways. diagnostic usage,unassigned 1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30277116&form=6&db=m Non-NAD-like PARP1 inhibitor enhanced synthetic lethal effect of NAD-like PARP inhibitors against BRCA1-deficient leukemia. therapeutic application,unassigned 4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30354818&form=6&db=m PARP-1 (Poly[ADP-Ribose] Polymerase 1) Inhibition Protects From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm in Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30431088&form=6&db=m PARP inhibitor re?sensitizes Adriamycin resistant leukemia cells through DNA damage and apoptosis. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30656896&form=6&db=m BRCA1 deficiency and synthetic lethality in leukemias; not only gene mutation matters. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31633196&form=6&db=m To PARP or not to PARP?-Toward sensitizing acute myeloid leukemia stem cells to immunotherapy. ongoing research,unassigned 3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31775111&form=6&db=m Novel deazaflavin tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors. ongoing research,unassigned 1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31810230&form=6&db=m Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31816060&form=6&db=m Inhibition of the mutated c-KIT kinase in AML1-ETO-positive leukemia cells restores sensitivity to PARP inhibitor. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32482307&form=6&db=m PARP goes the weasel! Emerging role of PARP inhibitors in acute leukemias. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32487599&form=6&db=m PARP Inhibitors as Therapeutic Options for Tyrosine Kinase-dependent Leukemia: A Review. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32996365&form=6&db=m MiR-181a enhances drug sensitivity of mixed lineage leukemia-rearranged acute myeloid leukemia by increasing poly(ADP-ribose) polymerase1 acetylation. unassigned - 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33071527&form=6&db=m Novel allosteric PARP1 inhibitors for the treatment of BRCA-deficient leukemia. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33092495&form=6&db=m Cellular and biochemical antileukemic mechanisms of the meroterpenoid Oncocalyxone A. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33161122&form=6&db=m Cytotoxic components from the leaves of Erythrophleum fordii induce human acute leukemia cell apoptosis through caspase 3 activation and PARP cleavage. ongoing research,unassigned 3,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33512458&form=6&db=m Modeling and targeting of erythroleukemia by hematopoietic genome editing. therapeutic application,unassigned 4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33820831&form=6&db=m Poly(ADP-Ribose) Polymerase Inhibitors for Arsenic Trioxide-Resistant Acute Promyelocytic Leukemia: Synergistic In Vitro Antitumor Effects with Hypomethylating Agents or High-Dose Vitamin C. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34048499&form=6&db=m Cytotoxicity of Gymnopilus purpureosquamulosus extracts on hematologic malignant cells through activation of the SAPK/JNK signaling pathway. ongoing research,unassigned 2,0 2.4.2.30 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34215619&form=6&db=m TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=230509&form=6&db=m Induction of erythroid differentiation of murine erythroleukemia cells by nicotinamide and related compounds. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2121511&form=6&db=m Mitosis may be an obligatory route to terminal differentiation in the Friend erythroleukemia cell. therapeutic application,unassigned 3,0 2.4.2.30 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25997834&form=6&db=m Berberis libanotica extract targets NF-?B/COX-2, PI3K/Akt and mitochondrial/caspase signalling to induce human erythroleukemia cell apoptosis. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29990873&form=6&db=m A novel synthesized 3', 5'-diprenylated chalcone mediates the proliferation of human leukemia cells by regulating apoptosis and autophagy pathways. diagnostic usage,unassigned 1,0 2.4.2.30 Leukemia, Hairy Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29969371&form=6&db=m Cladribine in combination with entinostat synergistically elicits anti-proliferative/anti-survival effects on multiple myeloma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3108318&form=6&db=m Role of nicotinamide adenine dinucleotide and adenosine triphosphate in glucocorticoid-induced cytotoxicity in susceptible lymphoid cells. ongoing research,unassigned 1,0 2.4.2.30 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8221673&form=6&db=m Poly(ADP-ribose) polymerase can bind melphalan damaged DNA. causal interaction,unassigned 3,0 2.4.2.30 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12171907&form=6&db=m Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage. unassigned - 2.4.2.30 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22120020&form=6&db=m A subset of chronic lymphocytic leukemia patients display reduced levels of PARP1 expression coupled with a defective irradiation-induced apoptosis. therapeutic application,unassigned 1,0 2.4.2.30 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24439051&form=6&db=m Poly(ADP-ribose) polymerase inhibitor CEP-8983 synergizes with bendamustine in chronic lymphocytic leukemia cells in vitro. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28751718&form=6&db=m Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia. therapeutic application,unassigned 1,0 2.4.2.30 Leukemia, Monocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30354818&form=6&db=m PARP-1 (Poly[ADP-Ribose] Polymerase 1) Inhibition Protects From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm in Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18314489&form=6&db=m Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20704577&form=6&db=m Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs) exert their anti-proliferative activity by interfering with Akt-mTOR signaling and bax:bcl-2 ratio modulation in cells from chronic myeloid leukemic patients. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25828893&form=6&db=m c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase-Activated Leukemias. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26408682&form=6&db=m Hyaluronic Acid Inhibitor 4-Methylumbelliferone Activates the Intrinsic Apoptosis Pathway in K562 Chronic Myelogenous Leukemia Cells. therapeutic application,unassigned 3,0 2.4.2.30 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28403785&form=6&db=m Apoptotic effects of some tetrahydronaphthalene derivatives on K562 human chronic myelogenous leukemia cell line. therapeutic application,unassigned 1,0 2.4.2.30 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29932782&form=6&db=m PARP1 inhibitor eliminated imatinib-refractory chronic myeloid leukemia cells in bone marrow microenvironment conditions. therapeutic application,unassigned 3,0 2.4.2.30 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31309361&form=6&db=m Targeting autophagy potentiates the anti-tumor effect of PARP inhibitor in pediatric chronic myeloid leukemia. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10887136&form=6&db=m Gi and Gq/11 proteins are involved in dissemination of myeloid leukemia cells to the liver and spleen, whereas bone marrow colonization involves Gq/11 but not Gi. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12382020&form=6&db=m PK11195, an isoquinoline carboxamide ligand of the mitochondrial benzodiazepine receptor, increased drug uptake and facilitated drug-induced apoptosis in human multidrug-resistant leukemia cells in vitro. ongoing research,unassigned 3,0 2.4.2.30 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15756438&form=6&db=m Antiproliferation effects of ponicidin on human myeloid leukemia cells in vitro. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17156654&form=6&db=m [Apoptosis of myeloid leukemia cell line HL60 induced by Bortezomib, a proteasome inhibitor] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4 2.4.2.30 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24895135&form=6&db=m Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression. therapeutic application,unassigned 3,0 2.4.2.30 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28968948&form=6&db=m Antinflammatory and anticancer effects of terpenes from oily fractions of Teucruim alopecurus, blocker of I?B? kinase, through downregulation of NF-?B activation, potentiation of apoptosis and suppression of NF-?B-regulated gene expression. therapeutic application,unassigned 3,0 2.4.2.30 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31001476&form=6&db=m TET2 Function in Hematopoietic Malignancies, Immune Regulation, and DNA Repair. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33444891&form=6&db=m Poly(ADP-ribose) polymerase inhibitor-associated myelodysplastic syndrome/acute myeloid leukemia: a pharmacovigilance analysis of the FAERS database. diagnostic usage,unassigned 3,0 2.4.2.30 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33952464&form=6&db=m PARP1 Is Overexpressed in Hematological Malignant Cell Lines: A Framework for Experimental Oncology. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11313278&form=6&db=m Regulation of the nuclear proteasome activity in myelomonocytic human leukemia cells after adriamycin treatment. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19407318&form=6&db=m Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20699436&form=6&db=m The vascular targeting agent combretastatin-A4 and a novel cis-Restricted {beta}-Lactam Analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25483710&form=6&db=m BRCA1, PARP1 and ?H2AX in acute myeloid leukemia: Role as biomarkers of response to the PARP inhibitor olaparib. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,4 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26314963&form=6&db=m Inhibition of poly(ADP-ribose) polymerase 1 protects against acute myeloid leukemia by suppressing the myeloproliferative leukemia virus oncogene. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26634675&form=6&db=m PARP Inhibitors Suppress AML1-ETO- and PML-RAR?-Positive Leukemia. therapeutic application,unassigned 3,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26967466&form=6&db=m Olaparib for the treatment of epithelial ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27473567&form=6&db=m PARP-inhibitor-induced synthetic lethality for acute myeloid leukemia treatment. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27503200&form=6&db=m A phase 1 study of the PARP inhibitor veliparib in combination with temozolomide in acute myeloid leukemia. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27728808&form=6&db=m Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29397193&form=6&db=m The poly (ADP ribose) polymerase inhibitor niraparib: Management of toxicities. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29526802&form=6&db=m The poly(ADP-ribose) polymerase inhibitor olaparib induces up-regulation of death receptors in primary acute myeloid leukemia blasts by NF-?B activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29633598&form=6&db=m The Association between PARP1 and LIG3 Expression Levels and Chromosomal Translocations in Acute Myeloid Leukemia Patients. causal interaction,diagnostic usage,unassigned 1,1,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29812960&form=6&db=m PARP-1 Overexpression as an Independent Prognostic Factor in Adult Non-M3 Acute Myeloid Leukemia. causal interaction,diagnostic usage,unassigned 3,3,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30184499&form=6&db=m PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30472087&form=6&db=m High PARP-1 expression predicts poor survival in acute myeloid leukemia and PARP-1 inhibitor and SAHA-bendamustine hybrid inhibitor combination treatment synergistically enhances anti-tumor effects. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,4 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30559256&form=6&db=m NF?B and Poly (ADP-ribose) Polymerase 1 Form a Positive Feedback Loop that Regulates DNA Repair in Acute Myeloid Leukemia Cells. therapeutic application,unassigned 3,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30615982&form=6&db=m Synergistic Cytotoxic Effect of Busulfan and the PARP Inhibitor Veliparib in Myeloproliferative Neoplasms. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30953707&form=6&db=m Partnering with PARP inhibitors in acute myeloid leukemia with FLT3-ITD. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31633196&form=6&db=m To PARP or not to PARP?-Toward sensitizing acute myeloid leukemia stem cells to immunotherapy. ongoing research,unassigned 3,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32423430&form=6&db=m Different regulation of PARP1, PARP2, PARP3 and TRPM2 genes expression in acute myeloid leukemia cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32482307&form=6&db=m PARP goes the weasel! Emerging role of PARP inhibitors in acute leukemias. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34207065&form=6&db=m Omics Technologies to Decipher Regulatory Networks in Granulocytic Cell Differentiation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34529761&form=6&db=m Poly (ADP-ribose) polymerase-1 (PARP1) as a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Leukemia, Myelomonocytic, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27551000&form=6&db=m A Phase I study of topotecan, carboplatin and the PARP inhibitor veliparib in acute leukemias, aggressive myeloproliferative neoplasms and chronic myelomonocytic leukemia. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Leukemia, Promyelocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8788037&form=6&db=m Overexpression of poly(ADP-ribose) polymerase promotes cell cycle arrest and inhibits neutrophilic differentiation of NB4 acute promyelocytic leukemia cells. causal interaction,unassigned 4,0 2.4.2.30 Leukemia, Promyelocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33820831&form=6&db=m Poly(ADP-Ribose) Polymerase Inhibitors for Arsenic Trioxide-Resistant Acute Promyelocytic Leukemia: Synergistic In Vitro Antitumor Effects with Hypomethylating Agents or High-Dose Vitamin C. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10666246&form=6&db=m Identification of poly(ADP-ribose) polymerase as a transcriptional coactivator of the human T-cell leukemia virus type 1 Tax protein. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12036322&form=6&db=m Sequence-specific binding of poly(ADP-ribose) polymerase-1 to the human T cell leukemia virus type-I tax responsive element. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12351627&form=6&db=m Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Leukemia-Lymphoma, Adult T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26497583&form=6&db=m Small PARP inhibitor PJ-34 induces cell cycle arrest and apoptosis of adult T-cell leukemia cells. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Leukocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1533239&form=6&db=m Effect of pertussis toxin on susceptibility of infant rats to Haemophilus influenzae type b. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.4.2.30 Leukocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3570457&form=6&db=m Immune response to the B oligomer of pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Leukocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8502521&form=6&db=m Severe reactions associated with diphtheria-tetanus-pertussis vaccine: detailed study of children with seizures, hypotonic-hyporesponsive episodes, high fevers, and persistent crying. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.4.2.30 Leukocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9167008&form=6&db=m Collaborative study on test systems to assess toxicity of whole cell pertussis vaccine. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Leukocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10626903&form=6&db=m Pertussis toxin treatment in vivo reduces surface expression of the adhesion integrin leukocyte function antigen-1 (LFA-1). ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Leukocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12595443&form=6&db=m Analysis of the role of Bphs/Hrh1 in the genetic control of responsiveness to pertussis toxin. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Leukocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26631634&form=6&db=m A cocktail of humanized anti-pertussis toxin antibodies limits disease in murine and baboon models of whooping cough. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Leukocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27609461&form=6&db=m Pertussis Leukocytosis: Mechanisms, Clinical Relevance and Treatment. unassigned - 2.4.2.30 Leukocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30736722&form=6&db=m The prevention of severe pertussis and pertussis deaths in young infants. causal interaction,unassigned 4,0 2.4.2.30 Leukocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32076653&form=6&db=m Neutralization of pertussis toxin by a single antibody prevents clinical pertussis in neonatal baboons. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 2.4.2.30 Leukocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33059000&form=6&db=m The quantitative analysis of the mechanism involved in pertussis toxin-mediated cell clustering and its implications in the in vitro quality control of diphtheria tetanus and whole cell pertussis vaccines. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Leukoencephalopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21596035&form=6&db=m Neuroprotective potential of erythropoietin and its derivative carbamylated erythropoietin in periventricular leukomalacia. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Leukoencephalopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31897308&form=6&db=m PARP-1 deregulation in multiple sclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Leukoencephalopathy, Progressive Multifocal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31897308&form=6&db=m PARP-1 deregulation in multiple sclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Leukopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1318209&form=6&db=m Pertussis toxin induces bronchopulmonary hyperresponsiveness in guinea-pigs while antagonizing the effects of formyl-L-methionyl-L-leucyl-L-phenylalanine. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Leukoplakia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24403051&form=6&db=m Recurrent genomic alterations in sequential progressive leukoplakia and oral cancer: drivers of oral tumorigenesis? diagnostic usage,unassigned 1,0 2.4.2.30 Leukostasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15370362&form=6&db=m Peroxynitrite decomposition catalyst, FP15, and poly(ADP-ribose) polymerase inhibitor, PJ34, inhibit leukocyte entrapment in the retinal microcirculation of diabetic rats. unassigned - 2.4.2.30 Leukostasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19725100&form=6&db=m Fulminant pertussis: a multi-center study with new insights into the clinico-pathological mechanisms. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Lewy Body Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15257133&form=6&db=m The expression of PARP, NF-kappa B and parvalbumin is increased in Parkinson disease. causal interaction,unassigned 3,0 2.4.2.30 Li-Fraumeni Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11359911&form=6&db=m DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Lipid Metabolism Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30165350&form=6&db=m Inhibition of Poly(ADP-Ribose) Polymerase Increased Lipid Accumulation Through SREBP1 Modulation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Liposarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16455111&form=6&db=m Growth inhibitory effect of quercetin on SW 872 human liposarcoma cells. ongoing research,unassigned 2,0 2.4.2.30 Liposarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28399901&form=6&db=m Activity of trabectedin and the PARP inhibitor rucaparib in soft-tissue sarcomas. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24089324&form=6&db=m Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27318789&form=6&db=m Puerarin protects against CCl4-induced liver fibrosis in mice: possible role of PARP-1 inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28757911&form=6&db=m Baicalin Ameliorates Experimental Liver Cholestasis in Mice by Modulation of Oxidative Stress, Inflammation, and NRF2 Transcription Factor. unassigned - 2.4.2.30 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14767993&form=6&db=m Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20188823&form=6&db=m Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25634059&form=6&db=m Poly (ADP?ribose) polymerase? and cytochrome c?mediated apoptosis induces hepatocyte injury in a rat model of hyperammonia?induced hepatic failure. causal interaction,unassigned 4,0 2.4.2.30 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27984176&form=6&db=m PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28013023&form=6&db=m Metabolic roles of poly(ADP-ribose) polymerases. diagnostic usage,unassigned 3,0 2.4.2.30 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29317476&form=6&db=m Poly(ADP-Ribose) Polymerase Inhibitor PJ34 Attenuated Hepatic Triglyceride Accumulation in Alcoholic Fatty Liver Disease in Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31913745&form=6&db=m SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. ongoing research,unassigned 2,0 2.4.2.30 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34198048&form=6&db=m The impact of the phytotherapeutic agent quercetin on expression of genes and activity of signaling pathways. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34450194&form=6&db=m PARPs in lipid metabolism and related diseases. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27984176&form=6&db=m PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21703211&form=6&db=m Cytosolic phospholipase A(2)? protects against Fas- but not LPS-induced liver injury. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9040540&form=6&db=m Male rats fed methyl- and folate-deficient diets with or without niacin develop hepatic carcinomas associated with decreased tissue NAD concentrations and altered poly(ADP-ribose) polymerase activity. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12460917&form=6&db=m Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation. causal interaction,unassigned 3,0 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18695907&form=6&db=m PJ34, an inhibitor of PARP-1, suppresses cell growth and enhances the suppressive effects of cisplatin in liver cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20712901&form=6&db=m A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. unassigned - 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21093979&form=6&db=m Inhibition of poly (ADP-ribose) polymerase-1 enhances doxorubicin activity against liver cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24676941&form=6&db=m Synergistic effect of arginine-specific ADP-ribosyltransferase 1 and poly(ADP-ribose) polymerase-1 on apoptosis induced by cisplatin in CT26 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24903377&form=6&db=m Interference of Mucin 1 inhibits the growth of liver cancer cells by inducing mitochondria-mediated and death receptor-mediated cell apoptosis. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25066396&form=6&db=m Inhibited effects of veliparib combined doxorubicin for BEL-7404 proliferation of human liver cancer cell line. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25139788&form=6&db=m PARP inhibition and the radiosensitizing effects of the PARP inhibitor ABT-888 in in vitro hepatocellular carcinoma models. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25543761&form=6&db=m Expression of cluster of differentiation-95 and relevant signaling molecules in liver cancer. therapeutic application,unassigned 1,0 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25865228&form=6&db=m Autoimmune response to PARP and BRCA1/BRCA2 in cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26223923&form=6&db=m Synergistic suppressive effect of PARP-1 inhibitor PJ34 and HDAC inhibitor SAHA on proliferation of liver cancer cells. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26718026&form=6&db=m Anticancer effect of xanthohumol induces growth inhibition and apoptosis of human liver cancer through NF-?B/p53-apoptosis signaling pathway. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27164859&form=6&db=m Combination PARP and HDAC inhibition as a therapeutic strategy targeting liver cancer stem cells? therapeutic application,unassigned 4,0 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29408941&form=6&db=m Chromatin remodeler ALC1 prevents replication-fork collapse by slowing fork progression. unassigned - 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29805529&form=6&db=m Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. unassigned - 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30581004&form=6&db=m Repressing of NHERF1 inhibits liver cancer progression by promoting the production of ROS. causal interaction,unassigned 3,0 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31679697&form=6&db=m Veliparib overcomes multidrug resistance in liver cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31815045&form=6&db=m Disulfiram combined with copper induces immunosuppression via PD-L1 stabilization in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,1 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31941242&form=6&db=m [Overexpression of protein phosphatase 2 regulatory subunit B''? gene effect on proliferation and invasion of hepatoma cells]. ongoing research,unassigned 4,0 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33053171&form=6&db=m Direct measurement of protein-protein interactions by FLIM-FRET at UV laser-induced DNA damage sites in living cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33355125&form=6&db=m The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33668690&form=6&db=m Comparison of the Phytochemical Properties, Antioxidant Activity and Cytotoxic Effect on HepG2 Cells in Mongolian and Taiwanese Rhubarb Species. causal interaction,unassigned 1,0 2.4.2.30 Long QT Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32128485&form=6&db=m PARP inhibitor-induced torsades de pointes in long QT syndrome: a case report. causal interaction,unassigned 4,0 2.4.2.30 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2988944&form=6&db=m Use of transposon mutants to assess the role of exoenzyme S in chronic pulmonary disease due to Pseudomonas aeruginosa. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911336&form=6&db=m Poly(ADP-ribosyl)ation in asthma and other lung diseases. causal interaction,unassigned 4,0 2.4.2.30 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34085162&form=6&db=m Ubiquitin-Specific Protease 14 (USP14) Aggravates Inflammatory Response and Apoptosis of Lung Epithelial Cells in Pneumonia by Modulating Poly (ADP-Ribose) Polymerase-1 (PARP-1). causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Lung Diseases, Interstitial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33130698&form=6&db=m [Interstitial Pneumonia Caused by Olaparib during Treatment of Breast Cancer-A Case Report]. therapeutic application,unassigned 3,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3133480&form=6&db=m Alteration of pulmonary structure by Pseudomonas aeruginosa exoenzyme S. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8643465&form=6&db=m Excitotoxicity in the lung: N-methyl-D-aspartate-induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly(ADP-ribose) polymerase. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11841805&form=6&db=m Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,3 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12706764&form=6&db=m [Acute poisoning by chemical warfare agent: sulfur mustard] therapeutic application,unassigned 4,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15082289&form=6&db=m Role of poly(ADP-ribose) polymerase activation in the pathogenesis of cardiopulmonary dysfunction in a canine model of cardiopulmonary bypass. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15087818&form=6&db=m INO-1001 a novel poly(ADP-ribose) polymerase (PARP) inhibitor improves cardiac and pulmonary function after crystalloid cardioplegia and extracorporal circulation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15197441&form=6&db=m Role of PARP on iNOS pathway during endotoxin-induced acute lung injury. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15644425&form=6&db=m Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15749460&form=6&db=m Inhibition of poly(ADP-ribose) polymerase attenuates lung tissue damage after hind limb ischemia-reperfusion in rats. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16127429&form=6&db=m Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17220373&form=6&db=m Protective effect of orally administered carnosine on bleomycin-induced lung injury. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17395016&form=6&db=m Prolonged poly(ADP-ribose) polymerase-1 activity regulates JP-8-induced sustained cytokine expression in alveolar macrophages. causal interaction,unassigned 4,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17533414&form=6&db=m Therapeutic treatment with poly(ADP-ribose) polymerase inhibitors attenuates the severity of acute pancreatitis and associated liver and lung injury. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17575013&form=6&db=m Poly(ADP-ribose) polymerase-1 (PARP-1) controls lung cell proliferation and repair after hyperoxia-induced lung damage. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20346119&form=6&db=m Renal hypoperfusion and impaired endothelium-dependent vasodilation in an animal model of VILI: the role of the peroxynitrite-PARP pathway. causal interaction,ongoing research,unassigned 3,3,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20459596&form=6&db=m Pulmonary and renal protection: targeting PARP to ventilator-induced lung and kidney injury? therapeutic application,unassigned 2,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20833778&form=6&db=m Preexposure to hyperoxia causes increased lung injury and epithelial apoptosis in mice ventilated with high tidal volumes. unassigned - 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21477302&form=6&db=m Adrenomedullin in inflammatory process associated with experimental pulmonary fibrosis. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26334388&form=6&db=m Protective effect of polyphenols in an inflammatory process associated with experimental pulmonary fibrosis in mice. diagnostic usage,unassigned 1,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27271689&form=6&db=m Poly-ADP-ribose polymerase inhibition provides protection against lung injury in a rat paraquat toxicity model. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31710417&form=6&db=m Treatment with 3-aminobenzamide during ex vivo lung perfusion of damaged rat lungs reduces graft injury and dysfunction after transplantation. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32865668&form=6&db=m Pharmacological inhibition of poly (ADP-ribose) polymerase by olaparib ameliorates influenza-virus-induced pneumonia in mice. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33063092&form=6&db=m Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1315778&form=6&db=m Participation of poly(ADP-ribose) polymerase in the drug sensitivity in human lung cancer cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2504504&form=6&db=m Adenosine diphosphate ribosyl transferase responses to a standardized dose of hydrogen peroxide in the mononuclear leukocytes of patients with a diagnosis of cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10426793&form=6&db=m Ethnic differences in poly(ADP-ribose) polymerase pseudogene genotype distribution and association with lung cancer risk. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245429&form=6&db=m DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. ongoing research,unassigned 3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11941587&form=6&db=m [Distribution of poly(ADP-ribose) polymerase pseudogene polymorphism and association with susceptibility to lung cancer in Chinese people] diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12525876&form=6&db=m Synergistic anticancer action of reversibly and irreversibly acting ligands of poly (ADP-ribose) polymerase. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12851688&form=6&db=m Non-small and small cell lung carcinoma cell lines exhibit cell type-specific sensitivity to edelfosine-induced cell death and different cell line-specific responses to edelfosine treatment. unassigned - 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14504211&form=6&db=m No association between haplotypes of three variants (codon 81, 284, and 762) in poly(ADP-ribose) polymerase gene and risk of primary lung cancer. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15265683&form=6&db=m Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L). ongoing research,unassigned 3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15705867&form=6&db=m Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15831436&form=6&db=m P-glycoprotein-independent apoptosis induction by a novel synthetic compound, MMPT [5-[(4-methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazolone]. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17505006&form=6&db=m Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17720873&form=6&db=m Poly(ADP-ribose) polymerase-1 regulates vimentin expression in lung cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19029194&form=6&db=m Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans. diagnostic usage,unassigned 1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19381065&form=6&db=m Stimulatory heterotrimeric G protein augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 human lung cancer cells. ongoing research,unassigned 3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19960226&form=6&db=m Antitumor effect of BPR-DC-2, a novel synthetic cyclic cyanoguanidine derivative, involving the inhibition of MDR-1 expression and down-regulation of p-AKT and PARP-1 in lung cancer. therapeutic application,unassigned 1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20615389&form=6&db=m Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20878124&form=6&db=m Replication-dependent ?-H2AX formation is involved in docetaxel-induced apoptosis in NSCLC A549 cells. unassigned - 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21420246&form=6&db=m Functional Polymorphisms of Base Excision Repair Genes XRCC1 and APEX1 Predict Risk of Radiation Pneumonitis in Patients with Non-Small Cell Lung Cancer Treated with Definitive Radiation Therapy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21459711&form=6&db=m Voies de réparation de l'ADN et cancers bronchiques non à petites cellules : perspectives cliniques. ongoing research,unassigned 1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21590040&form=6&db=m Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21706479&form=6&db=m PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22011283&form=6&db=m Inhibition of poly(ADP-ribose) polymerase (PARP) induces apoptosis in lung cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22456940&form=6&db=m Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22689920&form=6&db=m BCL2 Suppresses PARP1 Function and Nonapoptotic Cell Death. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22961666&form=6&db=m Proteomic Profiling Identifies Dysregulated Pathways in Small Cell Lung Cancer and Novel Therapeutic Targets Including PARP1. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22969115&form=6&db=m A genetic snapshot of small cell lung cancer. causal interaction,unassigned 1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23160330&form=6&db=m PARP inhibitors in lung cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23239809&form=6&db=m Synergistic Effect of Olaparib with Combination of Cisplatin on PTEN-Deficient Lung Cancer Cells. therapeutic application,unassigned 4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23275151&form=6&db=m PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23410825&form=6&db=m PARP1 impact on DNA repair of platinum adducts: Preclinical and clinical read-outs. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23428903&form=6&db=m Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23451039&form=6&db=m New Approaches of PARP-1 Inhibitors in Human Lung Cancer Cells and Cancer Stem-Like Cells by Some Selected Anthraquinone-Derived Small Molecules. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23503473&form=6&db=m Tumor suppressor in lung cancer-1 (TSLC1) mediated by dual-regulated oncolytic adenovirus exerts specific antitumor actions in a mouse model. unassigned - 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23933993&form=6&db=m Silencing tankyrase and telomerase promotes A549 human lung adenocarcinoma cell apoptosis and inhibits proliferation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23966292&form=6&db=m EGFR-Activating Mutations Correlate with a Fanconi Anemia-like Cellular Phenotype That Includes PARP Inhibitor Sensitivity. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24077350&form=6&db=m Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24164298&form=6&db=m H2AX a promising biomarker for lung cancer: a review. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24191958&form=6&db=m PARP inhibitors: an interesting pathway also for Non-Small Cell Lung Cancer? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24245692&form=6&db=m Suppression of NF-?B signaling and P-glycoprotein function by gambogic acid synergistically potentiates adriamycin -induced apoptosis in lung cancer. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24528514&form=6&db=m Poly (ADP-ribose) polymerase 3 (PARP3), a potential repressor of telomerase activity. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24761869&form=6&db=m Expression of ERCC1, MSH2 and PARP1 in non-small cell lung cancer and prognostic value in patients treated with platinum-based chemotherapy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24796672&form=6&db=m ?-Hydroxyundec-9-enoic acid induces apoptosis through ROS-mediated endoplasmic reticulum stress in non-small cell lung cancer cells. therapeutic application,unassigned 2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24895135&form=6&db=m Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression. therapeutic application,unassigned 3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24897387&form=6&db=m PARP inhibitor activates the intrinsic pathway of apoptosis in primary lung cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25145669&form=6&db=m Synergy between the NAMPT inhibitor GMX1777(8) and pemetrexed in non-small cell lung cancer cells is mediated by PARP activation and enhanced NAD consumption. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25179837&form=6&db=m Correlation between PARP-1 Val762Ala polymorphism and the risk of lung cancer in a Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25225750&form=6&db=m PARP-1 rs3219073 polymorphism may contribute to susceptibility to lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25400754&form=6&db=m Clinical significance of NQO1 polymorphism and expression of p53, SOD2, PARP1 in limited-stage small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25747710&form=6&db=m Cepharanthine induces apoptosis through reactive oxygen species and mitochondrial dysfunction in human non-small-cell lung cancer cells. causal interaction,unassigned 4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25865228&form=6&db=m Autoimmune response to PARP and BRCA1/BRCA2 in cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25917317&form=6&db=m MiR-205 and miR-218 expression is associated with carboplatin chemoresistance and regulation of apoptosis via Mcl-1 and Survivin in lung cancer cells. unassigned - 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25917567&form=6&db=m FLLL12 induces apoptosis in lung cancer cells through a p53/p73-independent but death receptor 5-dependent pathway. diagnostic usage,unassigned 1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26087179&form=6&db=m CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis. diagnostic usage,unassigned 2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26286830&form=6&db=m Retraction Note to: Correlation between PARP-1 Val762Ala polymorphism and the risk of lung cancer in a Chinese population. unassigned - 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26293798&form=6&db=m Tankyrase 2 (TNKS2) polymorphism associated with risk in developing non-small cell lung cancer in a Chinese population. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26307684&form=6&db=m MicroRNA-224 is implicated in lung cancer pathogenesis through targeting caspase-3 and caspase-7. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26387143&form=6&db=m Negative prognostic value of high levels of intracellular poly(ADP-ribose) in non-small cell lung cancer. causal interaction,unassigned 1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26483957&form=6&db=m PARP1 Inhibitors: antitumor drug design. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26617760&form=6&db=m Tankyrase 1 polymorphism associated with an increased risk in developing non-small cell lung cancer in a Chinese population: a proof-of-principle study. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26647102&form=6&db=m Altered expression profile of apoptosis-related molecules correlated with clinicopathological factors in non-small-cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26779812&form=6&db=m Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26781309&form=6&db=m Biological evaluation of 2-arylidene-4, 7-dimethyl indan-1-one (FXY-1): a novel Akt inhibitor with potent activity in lung cancer. therapeutic application,unassigned 4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26885450&form=6&db=m Oncolytic newcastle disease virus triggers cell death of lung cancer spheroids and is enhanced by pharmacological inhibition of autophagy. therapeutic application,unassigned 2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26898760&form=6&db=m PARP1 enhances lung adenocarcinoma metastasis by novel mechanisms independent of DNA repair. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26975633&form=6&db=m APR-246 (PRIMA-1(MET)) strongly synergizes with AZD2281 (olaparib) induced PARP inhibition to induce apoptosis in non-small cell lung cancer cell lines. unassigned - 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27020103&form=6&db=m Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality. therapeutic application,unassigned 4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27055253&form=6&db=m Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27149849&form=6&db=m PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27280048&form=6&db=m Nanopharmaceutical Approach for Enhanced Anti-cancer Activity of Betulinic Acid in Lung-cancer Treatment via Activation of PARP: Interaction with DNA as a Target: -Anti-cancer Potential of Nano-betulinic Acid in Lung Cancer. therapeutic application,unassigned 3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27440269&form=6&db=m PARP Inhibitor Activity Correlates with SLFN11 Expression and Demonstrates Synergy with Temozolomide in Small Cell Lung Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27446448&form=6&db=m Pelargonium quercetorum Agnew induces apoptosis without PARP or cytokeratin 18 cleavage in non-small cell lung cancer cell lines. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27628049&form=6&db=m Synergistic effect of fenretinide and curcumin for treatment of non-small cell lung cancer. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27655641&form=6&db=m Uncovering synthetic lethal interactions for therapeutic targets and predictive markers in lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27739325&form=6&db=m A randomized Phase II study of veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in BRCA1/2 metastatic breast cancer: design and rationale. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27818294&form=6&db=m Molecular mechanism of Antrodia cinnamomea sulfated polysaccharide on the suppression of lung cancer cell growth and migration via induction of transforming growth factor ? receptor degradation. ongoing research,unassigned 2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27871924&form=6&db=m MiR-335 regulates the chemo-radioresistance of small cell lung cancer cells by targeting PARP-1. ongoing research,unassigned 1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28008145&form=6&db=m MSH2/BRCA1 expression as a DNA-repair signature predicting survival in early-stage lung cancer patients from the IFCT-0002 Phase 3 Trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28212573&form=6&db=m Dynamic variations in epithelial-to-mesenchymal transition (EMT), ATM, and SLFN11 govern response to PARP inhibitors and cisplatin in small cell lung cancer. therapeutic application,unassigned 3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28433158&form=6&db=m Characterization of a sulfated galactoglucan from Antrodia cinnamomea and its anticancer mechanism via TGF?/FAK/Slug axis suppression. unassigned - 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28460475&form=6&db=m Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signaling. unassigned - 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28461256&form=6&db=m Smoking History Predicts Sensitivity to PARP Inhibitor Veliparib in Patients with Advanced Non-Small Cell Lung Cancer. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28748826&form=6&db=m Smoking History Predicts Sensitivity to PARP Inhibitor Veliparib in Patients with Advanced Non-Small Cell Lung Cancer: Methodological Issues. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28843522&form=6&db=m WITHDRAWN: An analysis of the gene interaction networks identifying the role of PARP1 in metastasis of non-small cell lung cancer. ongoing research,unassigned 1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29152062&form=6&db=m Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29152079&form=6&db=m An analysis of the gene interaction networks identifying the role of PARP1 in metastasis of non-small cell lung cancer. ongoing research,unassigned 2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29306194&form=6&db=m Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29330466&form=6&db=m Target engagement imaging of PARP inhibitors in small-cell lung cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29453076&form=6&db=m Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29717133&form=6&db=m Kinesin light chain-4 depletion induces apoptosis of radioresistant cancer cells by mitochondrial dysfunction via calcium ion influx. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29746926&form=6&db=m Fucoidan upregulates TLR4/CHOP-mediated caspase-3 and PARP activation to enhance cisplatin-induced cytotoxicity in human lung cancer cells. ongoing research,unassigned 1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29849794&form=6&db=m Tetrandrine suppresses lung cancer growth and induces apoptosis, potentially via the VEGF/HIF-1?/ICAM-1 signaling pathway. ongoing research,unassigned 2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29906251&form=6&db=m Randomized, Double-Blind, Phase II Study of Temozolomide in Combination With Either Veliparib or Placebo in Patients With Relapsed-Sensitive or Refractory Small-Cell Lung Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,4 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29928326&form=6&db=m Miltirone-induced apoptosis in cisplatin-resistant lung cancer cells through upregulation of p53 signaling pathways. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29941481&form=6&db=m The Combination of the PARP Inhibitor Olaparib and the WEE1 Inhibitor AZD1775 as a New Therapeutic Option for Small Cell Lung Cancer. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30123351&form=6&db=m Phosphorylation of the Cytoskeletal Protein CAP1 Regulates Non-Small Cell Lung Cancer Survival and Proliferation by GSK3?. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30127774&form=6&db=m PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30145925&form=6&db=m Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. ongoing research,unassigned 1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30152517&form=6&db=m PARP inhibitors synergize with gemcitabine by potentiating DNA damage in non-small-cell lung cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30195072&form=6&db=m Preliminary evaluation of a novel 18F-labeled PARP-1 ligand for PET imaging of PARP-1 expression in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30327308&form=6&db=m A Phase I Dose-Escalation Study of Veliparib Combined with Carboplatin and Etoposide in Patients with Extensive-Stage Small Cell Lung Cancer and Other Solid Tumors. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30354077&form=6&db=m Nanoemulsion-Based Delivery of Fluorescent PARP Inhibitors in Mouse Models of Small Cell Lung Cancer. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30396948&form=6&db=m Phoyunnanin E Induces Apoptosis of Non-small Cell Lung Cancer Cells via p53 Activation and Down-regulation of Survivin. therapeutic application,unassigned 1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30466996&form=6&db=m Identification of amentoflavone as a potent highly selective PARP-1 inhibitor and its potentiation on carboplatin in human non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30589644&form=6&db=m PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30760478&form=6&db=m PARP Inhibitors: Extending Benefit Beyond BRCA Mutant Cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31148500&form=6&db=m Novel targeted strategies to overcome resistance in small-cell lung cancer: focus on PARP inhibitors and rovalpituzumab tesirine. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31215481&form=6&db=m MiR-7-5p-mediated downregulation of PARP1 impacts DNA homologous recombination repair and resistance to doxorubicin in small cell lung cancer. therapeutic application,unassigned 1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31216465&form=6&db=m Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31416802&form=6&db=m Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer. therapeutic application,unassigned 2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31438892&form=6&db=m Reduction of metastatic potential by inhibiting EGFR/Akt/p38/ERK signaling pathway and epithelial-mesenchymal transition after carbon ion exposure is potentiated by PARP-1 inhibition in non-small-cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31575562&form=6&db=m Temozolomide plus PARP Inhibition in Small-Cell Lung Cancer: Could Patient-Derived Xenografts Accelerate Discovery of Biomarker Candidates? therapeutic application,unassigned 2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31632027&form=6&db=m Photoluminescent And Self-Assembled Hyaluronic Acid-Zinc Oxide-Ginsenoside Rh2 Nanoparticles And Their Potential Caspase-9 Apoptotic Mechanism Towards Cancer Cell Lines. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31753490&form=6&db=m Non-small cell lung cancer cells with deficiencies in homologous recombination genes are sensitive to PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31786739&form=6&db=m Fluzoparib increases radiation sensitivity of non-small cell lung cancer (NSCLC) cells without BRCA1/2 mutation, a novel PARP1 inhibitor undergoing clinical trials. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31795418&form=6&db=m A Small Compound KJ-28d Enhances the Sensitivity of Non-Small Cell Lung Cancer to Radio- and Chemotherapy. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31877762&form=6&db=m NSCLC Mutated Isoforms of CCDC6 Affect the Intracellular Distribution of the Wild Type Protein Promoting Cisplatinum Resistance and PARP Inhibitors Sensitivity in Lung Cancer Cells. therapeutic application,unassigned 2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32048546&form=6&db=m Identifying new piperazine-based PARP1 inhibitors using text mining and integrated molecular modeling approaches. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32106385&form=6&db=m Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC). causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32257917&form=6&db=m Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad. causal interaction,unassigned 1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32373151&form=6&db=m Drug Targeting of Genomic Instability in Multiple Myeloma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32437065&form=6&db=m Anticarcinogenic effects of halofuginone on lung-derived cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32552309&form=6&db=m Improved radiosynthesis of 123I-MAPi, an auger theranostic agent. ongoing research,unassigned 1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32814472&form=6&db=m Inhibition of ELF3 confers synthetic lethality of PARP inhibitor in non-small cell lung cancer. therapeutic application,unassigned 3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32859985&form=6&db=m XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33069237&form=6&db=m The dual HDAC-PI3K inhibitor CUDC-907 displays single-agent activity and synergizes with PARP inhibitor olaparib in small cell lung cancer. therapeutic application,unassigned 3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33134168&form=6&db=m The MYC Paralog-PARP1 Axis as a Potential Therapeutic Target in MYC Paralog-Activated Small Cell Lung Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33209463&form=6&db=m PARP inhibitors for small cell lung cancer and their potential for integration into current treatment approaches. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33262140&form=6&db=m Phase I and Pharmacologic Study of Olaparib in Combination with High-dose Radiotherapy with and without Concurrent Cisplatin for Non-Small Cell Lung Cancer. therapeutic application,unassigned 4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33284833&form=6&db=m Association of PARP1-specific polymorphisms and haplotypes with non-small cell lung cancer subtypes. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,1,1 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33327489&form=6&db=m Albanol B from Mulberries Exerts Anti-Cancer Effect through Mitochondria ROS Production in Lung Cancer Cells and Suppresses In Vivo Tumor Growth. therapeutic application,unassigned 1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33402194&form=6&db=m Correction to: The dual HDAC-PI3K inhibitor CUDC-907 displays single-agent activity and synergizes with PARP inhibitor olaparib in small cell lung cancer. therapeutic application,unassigned 3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33417952&form=6&db=m PARP-1 induces EMT in non-small cell lung carcinoma cells via modulating the transcription factors Smad4, p65 and ZEB1. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33493586&form=6&db=m XPO1 inhibition synergizes with PARP1 inhibition in small cell lung cancer by targeting nuclear transport of FOXO3a. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33578789&form=6&db=m PARP Inhibitors in Small-Cell Lung Cancer: Rational Combinations to Improve Responses. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33691794&form=6&db=m Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33745865&form=6&db=m A Dose-finding Study Followed by a Phase II Randomized, Placebo-controlled Trial of Chemoradiotherapy With or Without Veliparib in Stage III Non-small-cell Lung Cancer: SWOG 1206 (8811). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33774805&form=6&db=m PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33877317&form=6&db=m Purpurin, a anthraquinone induces ROS-mediated A549 lung cancer cell apoptosis via inhibition of PI3K/AKT and proliferation. causal interaction,unassigned 1,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33947690&form=6&db=m Veliparib in Combination with Carboplatin and Etoposide in Patients with Treatment-Naïve Extensive-Stage Small Cell Lung Cancer: A Phase 2 Randomized Study. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34050966&form=6&db=m Radiosynthesis of 3 H- and 14 C-labeled Veliparib. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34132814&form=6&db=m Association of T2285C polymorphism in PARP1 gene coding region with its expression, activity and NSCLC risk along with prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34145376&form=6&db=m A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34329582&form=6&db=m The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34463214&form=6&db=m Unveiling the mechanistic roles of chlorine substituted phthalazinone-based compounds containing chlorophenyl moiety towards the differential inhibition of poly (ADP-ribose) polymerase-1 in the treatment of lung cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34471490&form=6&db=m Revealing biomarkers associated with PARP inhibitors based on genetic interactions in cancer genome. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34478166&form=6&db=m JASPER: Phase 2 trial of first-line niraparib plus pembrolizumab in patients with advanced non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7923925&form=6&db=m Autoantibodies reacting with poly(ADP-ribose) and with a zinc-finger functional domain of poly(ADP-ribose) polymerase involved in the recognition of damaged DNA. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10207165&form=6&db=m PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus. causal interaction,unassigned 4,0 2.4.2.30 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10524693&form=6&db=m Poly(ADP-ribose) polymerase alleles in French Caucasians are associated neither with lupus nor with primary antiphospholipid syndrome. GRAID Research Group. Group for Research on Auto-Immune Disorders. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10955365&form=6&db=m Poly(ADP-ribose) polymerase polymorphisms are not a genetic risk factor for systemic lupus erythematosus in German Caucasians. diagnostic usage,unassigned 3,0 2.4.2.30 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14709417&form=6&db=m Identification of autoantibody against poly (ADP-ribose) polymerase (PARP) fragment as a serological marker in systemic lupus erythematosus. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15187033&form=6&db=m Altered autoantigen structure in Sjögren's syndrome: implications for the pathogenesis of autoimmune tissue damage. ongoing research,unassigned 2,0 2.4.2.30 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16461442&form=6&db=m Poly(ADP-ribose) polymerase (PARP) polymorphisms associated with nephritis and arthritis in systemic lupus erythematosus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17311901&form=6&db=m Association of poly(ADP-ribose) polymerase 1 and a novel candidate locus, LOC127086, with systemic lupus erythematosus. causal interaction,unassigned 3,0 2.4.2.30 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19376176&form=6&db=m Poly(ADP-ribose) polymerase activity in systemic lupus erythematosis and systemic sclerosis. unassigned - 2.4.2.30 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20544540&form=6&db=m PARP activity and NAD concentration in PMC from patients affected by systemic sclerosis and lupus erythematosus. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21976405&form=6&db=m Constitutive abnormal expression of RasGRP-1 isoforms and low expression of PARP-1 in patients with systemic lupus erythematosus. diagnostic usage,unassigned 1,0 2.4.2.30 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30991045&form=6&db=m MiR-199-3p promotes ERK-mediated IL-10 production by targeting poly (ADP-ribose) Polymerase-1 in patients with systemic lupus erythematosus. unassigned - 2.4.2.30 Lymphangioleiomyomatosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24874429&form=6&db=m Rapamycin-resistant PARP1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis (LAM). causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21612407&form=6&db=m Lymph Node Metastasis of Gastric Cancer Is Associated with the Interaction Between Poly (ADP-Ribose) Polymerase 1 and Matrix Metallopeptidase 2. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.4.2.30 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22583356&form=6&db=m Down-regulation of Notch receptor signaling pathway induces caspase-dependent and caspase-independent apoptosis in lung squamous cell carcinoma cells. unassigned - 2.4.2.30 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27895737&form=6&db=m High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.4.2.30 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28101214&form=6&db=m PARP-1 may be involved in angiogenesis in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28123587&form=6&db=m Analysis of molecular markers as predictive factors of lymph node involvement in breast carcinoma. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31903985&form=6&db=m ERCC1, PARP-1, and AQP1 as predictive biomarkers in colon cancer patients receiving adjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1621656&form=6&db=m Clinical reactions and immunogenicity of the BIKEN acellular diphtheria and tetanus toxoids and pertussis vaccine in 4- through 6-year-old US children. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1778316&form=6&db=m A novel bivalent acellular pertussis vaccine based on the 69 kDa protein and FHA. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1960420&form=6&db=m The lymphocytosis promoting action of pertussis toxin can be mimicked in vitro. Holotoxin but not the B subunit inhibits invasion of human T lymphoma cells through fibroblast monolayers. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2174674&form=6&db=m Reovirus transport--studies using lymphocytosis promoting factor. ongoing research,unassigned 1,0 2.4.2.30 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2536043&form=6&db=m Bacterial toxins affect early events of T lymphocyte activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,2 2.4.2.30 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2613276&form=6&db=m Inhibition of lymphocyte circulation in mice by pertussis toxin. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2732469&form=6&db=m Molecular mechanisms of lymphocyte extravasation. III. The loss of lymphocyte extravasation potential induced by pertussis toxin is not mediated via the activation of protein kinase C. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2858396&form=6&db=m Effects of dexamethasone and indomethacin on the vascular beta 2-adrenolytic action of pertussis toxin in rats; a prostaglandin-mediated phenomenon. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2881931&form=6&db=m Antitoxin in human pertussis immune globulins. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8088866&form=6&db=m Studies on the lymphocytosis induced by pertussis toxin. ongoing research,unassigned 3,0 2.4.2.30 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8502521&form=6&db=m Severe reactions associated with diphtheria-tetanus-pertussis vaccine: detailed study of children with seizures, hypotonic-hyporesponsive episodes, high fevers, and persistent crying. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.4.2.30 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8989431&form=6&db=m The lymphocytosis-promoting agent pertussis toxin affects virus burden and lymphocyte distribution in the SIV-infected rhesus macaque. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1 2.4.2.30 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9210021&form=6&db=m Pertussis toxin induces lymphocytosis in rhesus macaques. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10626903&form=6&db=m Pertussis toxin treatment in vivo reduces surface expression of the adhesion integrin leukocyte function antigen-1 (LFA-1). ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10884797&form=6&db=m Marked increase in L-selectin-negative T cells in neonatal pertussis. The lymphocytosis explained? unassigned - 2.4.2.30 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15908393&form=6&db=m Infection of newborn piglets with Bordetella pertussis: a new model for pertussis. ongoing research,unassigned 1,0 2.4.2.30 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29592985&form=6&db=m Caffeine to prevent respiratory failure and improve outcome in infant pertussis. causal interaction,unassigned 4,0 2.4.2.30 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30736722&form=6&db=m The prevention of severe pertussis and pertussis deaths in young infants. causal interaction,unassigned 4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1960420&form=6&db=m The lymphocytosis promoting action of pertussis toxin can be mimicked in vitro. Holotoxin but not the B subunit inhibits invasion of human T lymphoma cells through fibroblast monolayers. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1967818&form=6&db=m Amplification of cyclic AMP generation reveals agonistic effects of certain beta-adrenergic antagonists. unassigned - 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1968926&form=6&db=m Interactions between a lymphoma membrane-associated guanosine 5'-triphosphate-binding protein and the cytoskeleton during receptor patching and capping. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2169284&form=6&db=m Pertussis toxin B-subunit-induced Ca2(+)-fluxes in Jurkat human lymphoma cells: the action of long-term pre-treatment with cholera and pertussis holotoxins. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2752606&form=6&db=m Dual effects of pertussis toxin on in vitro invasive behavior of metastatic lymphoma variants. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3009343&form=6&db=m The effects of benzamide ADP-ribosyl transferase inhibitors on cell survival and DNA strand-break repair in irradiated mammalian cells. therapeutic application,unassigned 4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3095921&form=6&db=m Pertussis toxin inhibition of B cell and macrophage responses to bacterial lipopolysaccharide. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3108318&form=6&db=m Role of nicotinamide adenine dinucleotide and adenosine triphosphate in glucocorticoid-induced cytotoxicity in susceptible lymphoid cells. ongoing research,unassigned 1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3383778&form=6&db=m Modulation of prolactin-stimulated Nb2 lymphoma cell mitogenesis by cholera toxin and pertussis toxin. ongoing research,unassigned 4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3652046&form=6&db=m Inhibition of lymphoma invasion and liver metastasis formation by pertussis toxin. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6142822&form=6&db=m Mechanism of pertussis toxin action on the adenylate cyclase system. Inhibition of the turn-on reaction of the inhibitory regulatory site. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6386524&form=6&db=m Pertussis toxin catalyzes the ADP-ribosylation of two distinct peptides, 40 and 41 kDa, in rat fat cell membranes. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7703525&form=6&db=m Effect of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose) polymerase, on cultured tumor cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8258703&form=6&db=m Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching. unassigned - 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647264&form=6&db=m Ligation of CD40 rescues Ramos-Burkitt lymphoma B cells from calcium ionophore- and antigen receptor-triggered apoptosis by inhibiting activation of the cysteine protease CPP32/Yama and cleavage of its substrate PARP. ongoing research,unassigned 2,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9398401&form=6&db=m Ligation of CD40 potentiates Fas-mediated activation of the cysteine protease CPP32, cleavage of its death substrate PARP, and apoptosis in Ramos-Burkitt lymphoma B cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9446803&form=6&db=m Apoptosis in the absence of cytochrome c accumulation in the cytosol. ongoing research,unassigned 3,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10449032&form=6&db=m Correlation of poly(ADP-ribose)polymerase and p53 expression levels in high-grade lymphomas. causal interaction,diagnostic usage,unassigned 4,4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10468853&form=6&db=m FADD expression and caspase activation in B-cell lymphomas resistant to Fas-mediated apoptosis. ongoing research,unassigned 4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10887136&form=6&db=m Gi and Gq/11 proteins are involved in dissemination of myeloid leukemia cells to the liver and spleen, whereas bone marrow colonization involves Gq/11 but not Gi. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11062748&form=6&db=m Modulation of the antiproliferative activity of anticancer drugs in hematopoietic tumor cell lines by the poly(ADP-ribose) polymerase inhibitor 6(5H)-phenanthridinone. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11182320&form=6&db=m Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. ongoing research,unassigned 2,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11439165&form=6&db=m Characterization of the human FLICE-inhibitory protein locus and comparison of the anti-apoptotic activity of four different flip isoforms. causal interaction,diagnostic usage,unassigned 1,1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11996891&form=6&db=m Modulation of pyridyl cyanoguanidine (CHS 828) induced cytotoxicity by 3-aminobenzamide in U-937 GTB cells. ongoing research,unassigned 3,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839981&form=6&db=m The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases. unassigned - 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14614022&form=6&db=m Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16061477&form=6&db=m B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. unassigned - 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16151646&form=6&db=m Motexafin gadolinium induces mitochondrially-mediated caspase-dependent apoptosis. ongoing research,unassigned 1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16301620&form=6&db=m An hour after immunization peritoneal B-1 cells are activated to migrate to lymphoid organs where within 1 day they produce IgM antibodies that initiate elicitation of contact sensitivity. unassigned - 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17260002&form=6&db=m Granzyme B leakage-induced apoptosis is a crucial mechanism of cell death in nasal-type NK/T-cell lymphoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19823047&form=6&db=m Immunohistochemical detection of poly(ADP-ribose) polymerase inhibition by ABT-888 in patients with refractory solid tumors and lymphomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20124459&form=6&db=m ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21269693&form=6&db=m Dimethyl sulfoxide activates tumor necrosis factor?-p53 mediated apoptosis and down regulates d-fructose-6-phosphate-2-kinase and lactate dehydrogenase-5 in Dalton's lymphoma in vivo. unassigned - 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21504625&form=6&db=m Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,4 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21795476&form=6&db=m Phase I Study of PARP Inhibitor ABT-888 in Combination with Topotecan in Adults with Refractory Solid Tumors and Lymphomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,4 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21876534&form=6&db=m Combined loss of p21(waf1/cip1) and p27(kip1) enhances tumorigenesis in mice. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21911376&form=6&db=m Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family. causal interaction,unassigned 4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21956491&form=6&db=m Poly(ADP-ribose) polymerase inhibitors combined with external beam and radioimmunotherapy to treat aggressive lymphoma. therapeutic application,unassigned 4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22030621&form=6&db=m Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition. causal interaction,unassigned 4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22170260&form=6&db=m Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks. causal interaction,unassigned 4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22416035&form=6&db=m Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22614020&form=6&db=m PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis. therapeutic application,unassigned 1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23449454&form=6&db=m HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23590234&form=6&db=m A role of intracellular mono-ADP-ribosylation in cancer biology. unassigned - 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24493735&form=6&db=m PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage. therapeutic application,unassigned 1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24650937&form=6&db=m Rationale for PARP inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24841718&form=6&db=m Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24903379&form=6&db=m A polysaccharide from the fruiting bodies of Agaricus blazei Murill induces caspase-dependent apoptosis in human leukemia HL-60 cells. causal interaction,unassigned 2,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25143154&form=6&db=m PARP1 expression in mantle cell lymphoma: the utility of PARP1 immunohistochemistry and its relationship with markers of DNA damage. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25845326&form=6&db=m Quercetin-3-O-(2?-galloyl)-?-L-rhamnopyranoside attenuates cholesterol oxidation product-induced apoptosis by suppressing NF-?B-mediated cell death process in differentiated PC12 cells. unassigned - 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26209360&form=6&db=m Inhibition of cytochrome P450 2J2 by tanshinone IIA induces apoptotic cell death in hepatocellular carcinoma HepG2 cells. causal interaction,ongoing research,unassigned 4,3,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26921193&form=6&db=m PARP activation promotes nuclear AID accumulation in lymphoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27605053&form=6&db=m Leukemic non-nodal mantle cell lymphomas have a distinct phenotype and are associated with deletion of PARP1 and 13q14. causal interaction,unassigned 2,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28105679&form=6&db=m Robust immunoglobulin class switch recombination and end joining in Parp9-deficient mice. causal interaction,unassigned 3,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28394191&form=6&db=m The PARP inhibitor olaparib enhances the cytotoxicity of combined gemcitabine, busulfan and melphalan in lymphoma cells. therapeutic application,unassigned 1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28643365&form=6&db=m A multi-centre phase I trial of the PARP inhibitor olaparib in patients with relapsed chronic lymphocytic leukaemia, T-prolymphocytic leukaemia or mantle cell lymphoma. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28666825&form=6&db=m Triptonide acts as a novel potent anti-lymphoma agent with low toxicity mainly through inhibition of proto-oncogene Lyn transcription and suppression of Lyn signal pathway. therapeutic application,unassigned 1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28950661&form=6&db=m Linarin sensitizes tumor necrosis factor-related apoptosis (TRAIL)-induced ligand-triggered apoptosis in human glioma cells and in xenograft nude mice. unassigned - 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28983625&form=6&db=m Resveratrol inhibits proliferation and migration through SIRT1 mediated post?translational modification of PI3K/AKT signaling in hepatocellular carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29080451&form=6&db=m Curcumin sensitizes lymphoma cells to DNA damage agents through regulating Rad51-dependent homologous recombination. causal interaction,unassigned 1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29423093&form=6&db=m Combination of a hypomethylating agent and inhibitors of PARP and HDAC traps PARP1 and DNMT1 to chromatin, acetylates DNA repair proteins, down-regulates NuRD and induces apoptosis in human leukemia and lymphoma cells. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30128030&form=6&db=m PARP9 is overexpressed in human breast cancer and promotes cancer cell migration. causal interaction,diagnostic usage,unassigned 2,1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30146791&form=6&db=m Antrodia salmonea-induced oxidative stress abrogates HER-2 signaling cascade and enhanced apoptosis in ovarian carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30816498&form=6&db=m Chlorophyllin e6?mediated photodynamic therapy inhibits proliferation and induces apoptosis in human bladder cancer cells. diagnostic usage,unassigned 2,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30943029&form=6&db=m 3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31775111&form=6&db=m Novel deazaflavin tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors. ongoing research,unassigned 1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32093273&form=6&db=m The Effects of 5,6,7,8,3',4'-Hexamethoxyflavone on Apoptosis of Cultured Human Choriocarcinoma Trophoblast Cells. diagnostic usage,unassigned 3,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33053749&form=6&db=m The In Vitro and In Vivo Anticancer Properties of Chalcone Flavokawain B through Induction of ROS-Mediated Apoptotic and Autophagic Cell Death in Human Melanoma Cells. therapeutic application,unassigned 2,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33506273&form=6&db=m Assessment of diarrhea as side effect of oral targeted antineoplastic agents in clinical practice. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33838689&form=6&db=m Effect of Shuangdan Mingmu capsule, a Chinese herbal formula, on oxidative stress-induced apoptosis of pericytes through PARP/GAPDH pathway. ongoing research,unassigned 4,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34031264&form=6&db=m Antrodia salmonea induces apoptosis and enhances cytoprotective autophagy in colon cancer cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34048499&form=6&db=m Cytotoxicity of Gymnopilus purpureosquamulosus extracts on hematologic malignant cells through activation of the SAPK/JNK signaling pathway. ongoing research,unassigned 2,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8258703&form=6&db=m Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11857494&form=6&db=m Apoptosis in B-cell lymphomas and reactive lymphoid tissues always involves activation of caspase 3 as determined by a new in situ detection method. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20123594&form=6&db=m Toona sinensis extracts induced cell cycle arrest and apoptosis in the human lung large cell carcinoma. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20974632&form=6&db=m Serum-free corneal organ culture medium (SFM) but not conventional minimal essential organ culture medium (MEM) protects human corneal endothelial cells from apoptotic and necrotic cell death. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21467635&form=6&db=m Inulin Induces Dendritic Cells Apoptosis through the Caspase-Dependent Pathway and Mitochondrial Dysfunction. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21590040&form=6&db=m Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22527937&form=6&db=m Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NF?B signaling in HER2-overexpressing breast cancer cells. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22689920&form=6&db=m BCL2 Suppresses PARP1 Function and Nonapoptotic Cell Death. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22753732&form=6&db=m Anticancer effects of eleven triterpenoids derived from Antrodia camphorata. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23963693&form=6&db=m Anti-proliferative and apoptosis inducing effect of nimbolide by altering molecules involved in apoptosis and IGF signalling via PI3K/Akt in prostate cancer (PC-3) cell line. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24604693&form=6&db=m Polychlorinated biphenyl quinone induces mitochondrial-mediated and caspase-dependent apoptosis in HepG2 cells. causal interaction,unassigned 2,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25043952&form=6&db=m The role of mitogen-activated protein kinase in cadmium-induced primary rat cerebral cortical neurons apoptosis via a mitochondrial apoptotic pathway. ongoing research,unassigned 1,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25310109&form=6&db=m Celastrol induces the apoptosis of breast cancer cells and inhibits their invasion via downregulation of MMP-9. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25845326&form=6&db=m Quercetin-3-O-(2?-galloyl)-?-L-rhamnopyranoside attenuates cholesterol oxidation product-induced apoptosis by suppressing NF-?B-mediated cell death process in differentiated PC12 cells. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25868101&form=6&db=m Apoptosis in human compressive myelopathy due to metastatic neoplasia. diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26221596&form=6&db=m Role of Exogenous Hsp72 on Liver Dysfunction during Sepsis. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26498992&form=6&db=m Anti-cancer effects of 2-oxoquinoline derivatives on the HCT116 and LoVo human colon cancer cell lines. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27003169&form=6&db=m Cadmium Activates Reactive Oxygen Species-dependent AKT/mTOR and Mitochondrial Apoptotic Pathways in Neuronal Cells. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27073423&form=6&db=m Neuroprotective and antioxidant activities of bamboo salt soy sauce against H2O2-induced oxidative stress in rat cortical neurons. causal interaction,unassigned 1,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27215802&form=6&db=m A diphenyl diselenide-supplemented diet and swimming exercise promote neuroprotection, reduced cell apoptosis and glial cell activation in the hypothalamus of old rats. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27313717&form=6&db=m Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27446443&form=6&db=m Flavonoids isolated from Citrus platymamma induced G2/M cell cycle arrest and apoptosis in A549 human lung cancer cells. causal interaction,unassigned 2,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28101239&form=6&db=m Naphthazarin suppresses cell proliferation and induces apoptosis in human colorectal cancer cells via the B-cell lymphoma 2/B-cell associated X protein signaling pathway. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28314788&form=6&db=m The PARP inhibitor veliparib can be safely added to bendamustine and rituximab and has preliminary evidence of activity in B-cell lymphoma. therapeutic application,unassigned 2,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28544385&form=6&db=m Korean Red Ginseng Extract Enhances the Anticancer Effects of Sorafenib through Abrogation of CREB and c-Jun Activation in Renal Cell Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28551635&form=6&db=m Enhanced Susceptibility to 5-Fluorouracil in Human Colon Cancer Cells by Silencing of GRP78. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28599477&form=6&db=m Novel proapoptotic agent SM-1 enhances the inhibitory effect of 5-fluorouracil on colorectal cancer cells in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29061824&form=6&db=m Pipoxolan Exhibits Antitumor Activity Toward Oral Squamous Cell Carcinoma Through Reactive Oxygen Species-mediated Apoptosis. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29085508&form=6&db=m Triptolide induces DNA breaks, activates caspase-3-dependent apoptosis and sensitizes B-cell lymphoma to poly(ADP-ribose) polymerase 1 and phosphoinositide 3-kinase inhibitors. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29434894&form=6&db=m Down-expression of poly(ADP-ribose) polymerase in p53-regulated pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29490300&form=6&db=m Palmitic Acid-Induced Podocyte Apoptosis via the Reactive Oxygen Species-Dependent Mitochondrial Pathway. ongoing research,unassigned 3,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29541208&form=6&db=m miR-30d inhibits cell biological progression of Ewing's sarcoma by suppressing the MEK/ERK and PI3K/Akt pathways diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29552147&form=6&db=m Silencing LDHA inhibits proliferation, induces apoptosis and increases chemosensitivity to temozolomide in glioma cells. causal interaction,unassigned 4,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29722086&form=6&db=m Apoptotic effect of lambertianic acid through AMPK/FOXM1 signaling in MDA-MB231 breast cancer cells. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29762467&form=6&db=m Inhibition of Proliferation in U937 Cells Treated by Blue Light Irradiation and Combined Blue Light Irradiation/Drug. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29805557&form=6&db=m Knockdown of stromal interaction molecule 1 inhibits proliferation of colorectal cancer cells by inducing apoptosis. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29891925&form=6&db=m Cadmium-induced apoptosis in neuronal cells is mediated by Fas/FasL-mediated mitochondrial apoptotic signaling pathway. causal interaction,unassigned 1,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29928326&form=6&db=m Miltirone-induced apoptosis in cisplatin-resistant lung cancer cells through upregulation of p53 signaling pathways. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30233696&form=6&db=m Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis. causal interaction,diagnostic usage,unassigned 4,2,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30384491&form=6&db=m 3,5-Diethoxy-3'-Hydroxyresveratrol (DEHR) Ameliorates Liver Fibrosis via Caveolin-1 Activation in Hepatic Stellate Cells and in a Mouse Model of Bile Duct Ligation Injury. causal interaction,unassigned 2,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30652346&form=6&db=m Clinical case report of patients with osteosarcoma and anticancer benefit of calycosin against human osteosarcoma cells. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30689998&form=6&db=m Galbanic acid potentiates TRAIL induced apoptosis in resistant non-small cell lung cancer cells via inhibition of MDR1 and activation of caspases and DR5. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30890936&form=6&db=m Research Progress on PARP14 as a Drug Target. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30968736&form=6&db=m Target prioritization of novel substituted 5-aryl-2-oxo-/thioxo-2,3-dihydro-1H-benzo[6,7]chromeno[2,3-d]pyrimidine-4,6,11(5H)-triones as anticancer agents using in-silico approach. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31220671&form=6&db=m Protective effect of hypoxylonol C and 4,5,4',5'-tetrahydroxy-1,1'-binaphthyl isolated from Annulohypoxylon annulatum against streptozotocin-induced damage in INS-1 cells. causal interaction,unassigned 3,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31295870&form=6&db=m Analysis and Identification of Active Compounds from Gami-Soyosan Toxic to MCF-7 Human Breast Adenocarcinoma Cells. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31490284&form=6&db=m EX527, a Sirt-1 inhibitor, induces apoptosis in glioma via activating the p53 signaling pathway. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31729992&form=6&db=m Coix lacryma-jobi var. ma-yuen Stapf sprout extract induces cell cycle arrest and apoptosis in human cervical carcinoma cells. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32093273&form=6&db=m The Effects of 5,6,7,8,3',4'-Hexamethoxyflavone on Apoptosis of Cultured Human Choriocarcinoma Trophoblast Cells. diagnostic usage,unassigned 3,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32411699&form=6&db=m Non-esterified Fatty Acid Induce Dairy Cow Hepatocytes Apoptosis via the Mitochondria-Mediated ROS-JNK/ERK Signaling Pathway. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32431354&form=6&db=m Characterization and anti-tumor activity of saponin-rich fractions of South Korean sea cucumbers (Apostichopus japonicus). therapeutic application,unassigned 1,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32508655&form=6&db=m CCT020312 Inhibits Triple-Negative Breast Cancer Through PERK Pathway-Mediated G1 Phase Cell Cycle Arrest and Apoptosis. diagnostic usage,unassigned 1,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33266494&form=6&db=m Dehydroxyhispolon Methyl Ether, A Hispolon Derivative, Inhibits WNT/?-Catenin Signaling to Elicit Human Colorectal Carcinoma Cell Apoptosis. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33310307&form=6&db=m Inhibitory effects of nodakenin on inflammation and cell death in lipopolysaccharide-induced liver injury mice. unassigned - 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33668434&form=6&db=m Anti-Cancer Properties of Theaflavins. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33838689&form=6&db=m Effect of Shuangdan Mingmu capsule, a Chinese herbal formula, on oxidative stress-induced apoptosis of pericytes through PARP/GAPDH pathway. ongoing research,unassigned 4,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34359075&form=6&db=m Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34364837&form=6&db=m Anticancer effects of oleanolic acid on human melanoma cells. causal interaction,unassigned 1,0 2.4.2.30 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34425193&form=6&db=m Transferrin-conjugated liposomes loaded with carnosic acid inhibit liver cancer growth by inducing mitochondria-mediated apoptosis. causal interaction,ongoing research,unassigned 3,1,0 2.4.2.30 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11222085&form=6&db=m Mechanisms of JP-8 jet fuel toxicity. I. Induction of apoptosis in rat lung epithelial cells. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22689920&form=6&db=m BCL2 Suppresses PARP1 Function and Nonapoptotic Cell Death. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27288732&form=6&db=m Lysosomotropic cationic drugs induce cytostatic and cytotoxic effects: Role of liposolubility and autophagic flux and antagonism by cholesterol ablation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30890936&form=6&db=m Research Progress on PARP14 as a Drug Target. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Lymphoma, Mantle-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20124459&form=6&db=m ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Lymphoma, Mantle-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22170260&form=6&db=m Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks. causal interaction,unassigned 4,0 2.4.2.30 Lymphoma, Mantle-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22416035&form=6&db=m Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Lymphoma, Mantle-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24841718&form=6&db=m Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Lymphoma, Mantle-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25143154&form=6&db=m PARP1 expression in mantle cell lymphoma: the utility of PARP1 immunohistochemistry and its relationship with markers of DNA damage. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.4.2.30 Lymphoma, Mantle-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28643365&form=6&db=m A multi-centre phase I trial of the PARP inhibitor olaparib in patients with relapsed chronic lymphocytic leukaemia, T-prolymphocytic leukaemia or mantle cell lymphoma. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Lymphoma, Mantle-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28950661&form=6&db=m Linarin sensitizes tumor necrosis factor-related apoptosis (TRAIL)-induced ligand-triggered apoptosis in human glioma cells and in xenograft nude mice. unassigned - 2.4.2.30 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10449032&form=6&db=m Correlation of poly(ADP-ribose)polymerase and p53 expression levels in high-grade lymphomas. causal interaction,diagnostic usage,unassigned 4,4,0 2.4.2.30 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14646226&form=6&db=m Response of DNA repair enzymes in murine fibrosarcoma, lymphosarcoma and ascites cells following gamma irradiation. diagnostic usage,unassigned 3,0 2.4.2.30 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20196871&form=6&db=m PARP-1 Val762Ala polymorphism is associated with reduced risk of non-Hodgkin lymphoma in Korean males. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.4.2.30 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21779467&form=6&db=m Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21956491&form=6&db=m Poly(ADP-ribose) polymerase inhibitors combined with external beam and radioimmunotherapy to treat aggressive lymphoma. therapeutic application,unassigned 4,0 2.4.2.30 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22472897&form=6&db=m PARP-1 protein expression in glioblastoma multiforme. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Lymphoma, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9052744&form=6&db=m Molecular cloning of a functional murine arginine-specific mono-ADP-ribosyltransferase and its expression in lymphoid cells. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Lymphoma, T-Cell, Cutaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33017467&form=6&db=m The synergistic proapoptotic effect of PARP-1 and HDAC inhibition in cutaneous T-cell lymphoma is mediated via Blimp-1. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Lymphopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30996287&form=6&db=m Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33378949&form=6&db=m Protective effects of PARP1-inhibitory compound in dry age-related macular degeneration. unassigned - 2.4.2.30 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12888113&form=6&db=m The pathophysiology of falciparum malaria. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Mastitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30078582&form=6&db=m Assessment of Poly(ADP-ribose) Polymerase1 (PARP1) expression and activity in cells purified from blood and milk of dairy cattle. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.4.2.30 Mastitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33803196&form=6&db=m New Insights into the Significance of PARP-1 Activation: Flow Cytometric Detection of Poly(ADP-Ribose) as a Marker of Bovine Intramammary Infection. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1907493&form=6&db=m Characterization of cytosolic pertussis toxin-sensitive GTP-binding protein in mastocytoma P-815 cells. ongoing research,unassigned 3,0 2.4.2.30 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492835&form=6&db=m Trichostatin A induces apoptosis of p815 mastocytoma cells in histone acetylation- and mitochondria-dependent fashion. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Mastocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19383925&form=6&db=m Kit inhibitor APcK110 induces apoptosis and inhibits proliferation of acute myeloid leukemia cells. therapeutic application,unassigned 1,0 2.4.2.30 Measles http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11520252&form=6&db=m Antibody responses of healthy infants to concurrent administration of a bivalent haemophilus influenzae type b-hepatitis B vaccine with diphtheria-tetanus-pertussis, polio and measles-mumps-rubella vaccines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Measles http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33928900&form=6&db=m Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019. diagnostic usage,unassigned 2,0 2.4.2.30 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11403964&form=6&db=m Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12507884&form=6&db=m Medulloblastoma in mice lacking p53 and PARP: all roads lead to Gli. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12507917&form=6&db=m Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice. ongoing research,unassigned 2,0 2.4.2.30 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18660545&form=6&db=m PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19533660&form=6&db=m PARP1 expression in pediatric central nervous system tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 2.4.2.30 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20953661&form=6&db=m Expression of Gli1 and PARP1 in medulloblastoma: an immunohistochemical study of 65 cases. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.4.2.30 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20978505&form=6&db=m Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22184287&form=6&db=m PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27409836&form=6&db=m Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33996894&form=6&db=m Veliparib Is an Effective Radiosensitizing Agent in a Preclinical Model of Medulloblastoma. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34049392&form=6&db=m Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model. diagnostic usage,unassigned 3,0 2.4.2.30 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34508175&form=6&db=m A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1327852&form=6&db=m Murine melanoma cell differentiation and melanogenesis induced by poly(ADP-ribose) polymerase inhibitors. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1328249&form=6&db=m Type IV collagen stimulates an increase in intracellular calcium. Potential role in tumor cell motility. ongoing research,unassigned 3,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1733949&form=6&db=m Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein. therapeutic application,unassigned 1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1850381&form=6&db=m The role of G-protein in matrix-mediated motility of highly and poorly invasive melanoma cells. causal interaction,ongoing research,unassigned 3,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2477150&form=6&db=m G-protein involvement in matrix-mediated motility and invasion of high and low experimental metastatic B16 melanoma clones. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3496885&form=6&db=m Pertussis toxin inhibits stimulated motility independently of the adenylate cyclase pathway in human melanoma cells. therapeutic application,unassigned 2,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11112786&form=6&db=m A role for poly(ADP-ribose) polymerase in the transcriptional regulation of the melanoma growth stimulatory activity (CXCL1) gene expression. ongoing research,unassigned 2,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11142769&form=6&db=m Overexpression of HSP70 prevents ultraviolet B-induced apoptosis of a human melanoma cell line. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12488552&form=6&db=m Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12924949&form=6&db=m An amyloid-like C-terminal domain of thrombospondin-1 displays CD47 agonist activity requiring both VVM motifs. unassigned - 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14614022&form=6&db=m Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14692828&form=6&db=m Characterization of human melanoma cell lines according to their migratory properties in vitro. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15066181&form=6&db=m Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15091188&form=6&db=m c-Myc is able to sensitize human melanoma cells to diverse apoptotic triggers. therapeutic application,unassigned 4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15382061&form=6&db=m Tumor apoptosis induced by ruthenium(II)-ketoconazole is enhanced in nonsusceptible carcinoma by monoclonal antibody to EGF receptor. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15386369&form=6&db=m Loss of function of vascular smooth muscle cells by nitric oxide-dependent and -independent interactions with tumorigenic cells. ongoing research,unassigned 4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15548688&form=6&db=m Inhibition of melanoma growth and metastasis by ATF2-derived peptides. ongoing research,unassigned 1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15604257&form=6&db=m Endothelin receptor B inhibition triggers apoptosis and enhances angiogenesis in melanomas. causal interaction,unassigned 4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15609335&form=6&db=m Anti-proliferative and proapoptotic effects of (-)-epigallocatechin-3-gallate on human melanoma: possible implications for the chemoprevention of melanoma. therapeutic application,unassigned 1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15645126&form=6&db=m Brain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15867241&form=6&db=m Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,2 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15880533&form=6&db=m Cyclosporine A and its non-immunosuppressive derivative NIM811 induce apoptosis of malignant melanoma cells in in vitro and in vivo studies. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16084940&form=6&db=m Poly(adenosine diphosphate-ribose) polymerase 1 expression in malignant melanomas from photoexposed areas of the head and neck region. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16489094&form=6&db=m Human melanoma cells selected for resistance to apoptosis by prolonged exposure to tumor necrosis factor-related apoptosis-inducing ligand are more vulnerable to necrotic cell death induced by Cisplatin. ongoing research,unassigned 4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16621887&form=6&db=m Genetic variants of the ADPRT, XRCC1 and APE1 genes and risk of cutaneous melanoma. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16799643&form=6&db=m Differential regulation of CXC ligand 1 transcription in melanoma cell lines by poly(ADP-ribose) polymerase-1. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16970407&form=6&db=m Isolation, structure elucidation, total synthesis, and evaluation of new natural and synthetic ceramides on human SK-MEL-1 melanoma cells. ongoing research,unassigned 1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17203247&form=6&db=m Attenuation of genotoxicity under adhesion-restrictive conditions through modulation of p53, gamma H2AX and nuclear DNA organization. causal interaction,unassigned 4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17203890&form=6&db=m Mitochondrial transmembrane potential in spontaneous and camptothecin-induced apoptosis of melanotic and amelanotic melanoma cells. causal interaction,unassigned 1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17312383&form=6&db=m The activity of caspases in spontaneous and camptothecin-induced death of melanotic and amelanotic melanoma cell. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17510430&form=6&db=m Survivin, a member of the inhibitor of apoptosis family, is induced by photodynamic therapy and is a target for improving treatment response. therapeutic application,unassigned 2,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17904792&form=6&db=m Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18440222&form=6&db=m Stable depletion of poly (ADP-ribose) polymerase-1 reduces in vivo melanoma growth and increases chemosensitivity. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18752052&form=6&db=m Poly(Adenosine Diphosphate-Ribose) Polymerase-1 Expression in Cutaneous Malignant Melanomas as a New Molecular Marker of Aggressive Tumor. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19127257&form=6&db=m Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53. unassigned - 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19350633&form=6&db=m The melanoma specific 9.2.27PE immunotoxin efficiently kills melanoma cells in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19506078&form=6&db=m Arachidonic acid stimulates cell adhesion through a novel p38 MAPK-RhoA signaling pathway that involves heat shock protein 27. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19584767&form=6&db=m The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines. ongoing research,unassigned 2,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19890834&form=6&db=m Inhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20182810&form=6&db=m Inhibition of Poly(ADP-Ribose) Polymerase Enhances the Effect of Chemotherapy in an Animal Model of Regional Therapy for the Treatment of Advanced Extremity Malignant Melanoma. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20370684&form=6&db=m Pharmacological Inhibition of Poly(ADP-ribose) Polymerase (PARP) Activity in PARP-1 Silenced Tumour Cells Increases Chemosensitivity to Temozolomide and to a N3-Adenine Selective Methylating Agent. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20464779&form=6&db=m Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20837404&form=6&db=m Genetic variation in DNA repair pathway genes and melanoma risk. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21078385&form=6&db=m Combination of PDT and inhibitor treatment affects melanoma cells and spares keratinocytes. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21188975&form=6&db=m Lauroside B, a megastigmane glycoside from Laurus nobilis (bay laurel) leaves, induces apoptosis in human melanoma cell lines by inhibiting NF-?B activation. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21832879&form=6&db=m Metabolic utilization of exogenous pyruvate by mutant p53(R175H) human melanoma cells promotes survival under glucose depletion. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22334019&form=6&db=m Radiation-inducible Immunotherapy for Cancer: Senescent Tumor Cells as a Cancer Vaccine. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22419029&form=6&db=m Poly(ADP-ribose) in the skin and in melanomas. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22567084&form=6&db=m Deficiency of C-C chemokine receptor 5 suppresses tumor development via inactivation of NF-?B and upregulation of IL-1Ra in melanoma model. causal interaction,diagnostic usage,unassigned 3,2,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22627834&form=6&db=m RIN1 exhibits oncogenic property to suppress apoptosis and its aberrant accumulation associates with poor prognosis in melanoma. diagnostic usage,unassigned 3,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22687647&form=6&db=m Polymorphisms in base excision DNA repair genes and association with melanoma risk in a pilot study on Central-South Italian population. causal interaction,unassigned 2,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22915039&form=6&db=m Altered Expression of the Poly(ADP-Ribosyl)ation Enzymes in Uveal Melanoma and Regulation of PARG Gene Expression by the Transcription Factor ERM. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23049605&form=6&db=m The Antitumor Activity of Antrodia camphorata in Melanoma Cells: Modulation of Wnt/?-Catenin Signaling Pathways. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23423489&form=6&db=m A phase II study of the potent PARP inhibitor, Rucaparib (PF-01367338, AG014699), with temozolomide in patients with metastatic melanoma demonstrating evidence of chemopotentiation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23508743&form=6&db=m Methoxyphenylcipro induces antitumor activity in human cancer cells. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23537197&form=6&db=m Genetic variants in PARP1 (rs3219090) and IRF4 (rs12203592) genes associated with melanoma susceptibility in a Spanish population. unassigned - 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23785295&form=6&db=m PARP-1 regulates metastatic melanoma through modulation of vimentin-induced malignant transformation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24070777&form=6&db=m The toxicity of nitrofuran compounds on melanoma and neuroblastoma cells is enhanced by Olaparib and ameliorated by melanin pigment. therapeutic application,unassigned 2,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24100507&form=6&db=m MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cells. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24535833&form=6&db=m Inherited variation in the PARP1 gene and survival from melanoma. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24689276&form=6&db=m Evaluation of the anti-melanoma activities of sarcophine, (+)-7alpha,8beta-dihydroxydeepoxysarcophine and sarcophytolide from the Red Sea soft coral Sarcophyton glaucum. ongoing research,unassigned 3,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24971451&form=6&db=m Synergistic apoptosis-inducing effects on A375 human melanoma cells of natural borneol and curcumin. unassigned - 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25233593&form=6&db=m Evaluation of anti-melanoma activities of (1S,2E,4R,6E,8R,11S,12R)-8,12-epoxy-2,6-cembradiene-4,11-diol, (1S,2E,4R,6E,8S,11R,12S)-8,11-epoxy-4,12-epoxy-2,6-cembradiene and (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol from the Red Sea soft coral Sarcophyton glaucum. therapeutic application,unassigned 1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25331333&form=6&db=m PARP1 polymorphisms play opposing roles in melanoma occurrence and survival. causal interaction,diagnostic usage,unassigned 2,3,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25376115&form=6&db=m HDAC-inhibitor (S)-8 disrupts HDAC6-PP1 complex prompting A375 melanoma cell growth arrest and apoptosis. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25562667&form=6&db=m eIF4E Is an Adverse Prognostic Marker of Melanoma Patient Survival by Increasing Melanoma Cell Invasion. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25646931&form=6&db=m Prenylation Inhibition-Induced Cell Death in Melanoma: Reduced Sensitivity in BRAF Mutant/PTEN Wild-Type Melanoma Cells. ongoing research,unassigned 3,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25837821&form=6&db=m Inherited genetic variants associated with occurrence of multiple primary melanoma. diagnostic usage,unassigned 3,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25915038&form=6&db=m Activating the Wnt/?-Catenin Pathway for the Treatment of Melanoma--Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26483957&form=6&db=m PARP1 Inhibitors: antitumor drug design. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26505995&form=6&db=m Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26586345&form=6&db=m Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells. diagnostic usage,unassigned 3,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26633318&form=6&db=m Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26880244&form=6&db=m Xeroderma Pigmentosum Group A Promotes Autophagy to Facilitate Cisplatin Resistance in Melanoma Cells through the Activation of PARP1. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27128213&form=6&db=m PARP activity in peripheral blood lymphocytes as a predictive biomarker for PARP inhibition in tumor tissues - A population pharmacokinetic/pharmacodynamic analysis of rucaparib. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27252813&form=6&db=m Approach to the Triple Negative Breast Cancer in New Drugs Area. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27323414&form=6&db=m Iciartin, a novel FASN inhibitor, exerts anti-melanoma activities through IGF-1R/STAT3 signaling. unassigned - 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27468725&form=6&db=m Dimethylfumarate inhibits melanoma cell proliferation via p21 and p53 induction and bcl-2 and cyclin B1 downregulation. causal interaction,unassigned 3,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27476724&form=6&db=m Rare germline copy number variations and disease susceptibility in familial melanoma. unassigned - 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27705909&form=6&db=m PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28138035&form=6&db=m Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28208804&form=6&db=m Hazelnut (Corylus avellana L.) Shells Extract: Phenolic Composition, Antioxidant Effect and Cytotoxic Activity on Human Cancer Cell Lines. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28409496&form=6&db=m 4-Thiazolidinone derivative Les-3833 effectively inhibits viability of human melanoma cells through activating apoptotic mechanisms. therapeutic application,unassigned 1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28529590&form=6&db=m Cepharanthine exerts antitumor activity on choroidal melanoma by reactive oxygen species production and c-Jun N-terminal kinase activation. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28759004&form=6&db=m A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF. causal interaction,diagnostic usage,unassigned 3,3,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28808049&form=6&db=m The 1q42.1 Risk Allele Promotes Melanoma via PARP1 Upregulation. unassigned - 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28809055&form=6&db=m Apoptotic Effect of Astragalin in Melanoma Skin Cancers via Activation of Caspases and Inhibition of Sry-related HMg-Box Gene 10. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28923400&form=6&db=m MITF suppression improves the sensitivity of melanoma cells to a BRAF inhibitor. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29254481&form=6&db=m Melanoma cells replicate through chemotherapy by reducing levels of key homologous recombination protein RAD51 and increasing expression of translesion synthesis DNA polymerase ?. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29309290&form=6&db=m Blockade of BAFF Receptor BR3 on T Cells Enhances Their Activation and Cytotoxicity. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29725430&form=6&db=m Targeted silencing of the ADP-ribosyltransferase 3 gene inhibits the migration ability of melanoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29767266&form=6&db=m Inhibition of SOX4 induces melanoma cell apoptosis via downregulation of NF-?B p65 signaling. causal interaction,unassigned 4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29805679&form=6&db=m Enhanced anti-melanoma efficacy of interferon ?-2b via overexpression of ING4 by enhanced Fas/FasL-mediated apoptosis. ongoing research,unassigned 2,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29956724&form=6&db=m Effect of ABT-888 on the apoptosis, motility and invasiveness of BRAFi-resistant melanoma cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30740361&form=6&db=m Molecular, Biological and Structural Features of VL CDR-1 Rb44 Peptide, Which Targets the Microtubule Network in Melanoma Cells. causal interaction,unassigned 1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30989459&form=6&db=m 17-Aminogeldanamycin selectively diminishes IRE1?-XBP1s pathway activity and cooperatively induces apoptosis with MEK1/2 and BRAFV600E inhibitors in melanoma cells of different genetic subtypes. therapeutic application,unassigned 4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31005714&form=6&db=m Sasanquasaponin ??? from Schima crenata Korth induces autophagy through Akt/mTOR/p70S6K pathway and promotes apoptosis in human melanoma A375 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31133874&form=6&db=m PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31146482&form=6&db=m PARP Inhibition Increases the Response to Chemotherapy in Uveal Melanoma. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31185226&form=6&db=m Influence of onconase in the therapeutic potential of PARP inhibitors in A375 malignant melanoma cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31292999&form=6&db=m 4'-Bromo-resveratrol, a dual Sirtuin-1 and Sirtuin-3 inhibitor, inhibits melanoma cell growth through mitochondrial metabolic reprogramming. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,3 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31615091&form=6&db=m Topical 2'-Hydroxyflavanone for Cutaneous Melanoma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31783660&form=6&db=m Onconase Restores Cytotoxicity in Dabrafenib-Resistant A375 Human Melanoma Cells and Affects Cell Migration, Invasion and Colony Formation Capability. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31801187&form=6&db=m Dibutyltin(IV) and Tributyltin(IV) Derivatives of meso-Tetra(4-sulfonatophenyl)porphine Inhibit the Growth and the Migration of Human Melanoma Cells. causal interaction,unassigned 1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32048546&form=6&db=m Identifying new piperazine-based PARP1 inhibitors using text mining and integrated molecular modeling approaches. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32122513&form=6&db=m A dermatan sulfate-functionalized biomimetic nanocarrier for melanoma targeted chemotherapy. therapeutic application,unassigned 1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32122653&form=6&db=m Nitroprusside induces melanoma ferroptosis with serum supplementation and prolongs survival under serum depletion or hypoxia. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32380691&form=6&db=m Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,2 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32652466&form=6&db=m Exoenzyme C3 transferase lowers actin cytoskeleton dynamics, genomic stability and survival of malignant melanoma cells under UV-light stress. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32811446&form=6&db=m PARP inhibitors combined with ionizing radiation induce different effects in melanoma cells and healthy fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33006227&form=6&db=m BRIT-1 expression and its relationship with PARP-1 and CAF-1/p60 in cutaneous melanoma. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33163283&form=6&db=m Inhibition of AURKB, regulated by pseudogene MTND4P12, confers synthetic lethality to PARP inhibition in skin cutaneous melanoma. therapeutic application,unassigned 1,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33179075&form=6&db=m Tanshinone I and simvastatin inhibit melanoma tumour cell growth by regulating poly (ADP ribose) polymerase 1 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33308899&form=6&db=m Mutation clearance and complete radiologic resolution of immunotherapy relapsed metastatic melanoma after treatment with nivolumab and olaparib in a patient with homologous recombinant deficiency: any role for PARP inhibitors and checkpoint blockade? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33572586&form=6&db=m The Prognostic Values of PARP-1 Expression in Uveal Melanoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33572647&form=6&db=m PARP1 as a Marker of an Aggressive Clinical Phenotype in Cutaneous Melanoma-A Clinical and an In Vitro Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33581682&form=6&db=m Selective modulation by PARP-1 of HIF-1?-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33610559&form=6&db=m Prevalence of Homologous Recombination Pathway Gene Mutations in Melanoma: Rationale for a New Targeted Therapeutic Approach. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34050966&form=6&db=m Radiosynthesis of 3 H- and 14 C-labeled Veliparib. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34073147&form=6&db=m PARP Inhibitors Talazoparib and Niraparib Sensitize Melanoma Cells to Ionizing Radiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34342816&form=6&db=m A375 melanoma cells are sensitized to cisplatin-induced toxicity by a synthetic nitro-flavone derivative 2-(4-Nitrophenyl)-4H-chromen-4-one through inhibition of PARP1. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17449940&form=6&db=m Sphingosine 1-phosphate triggers apoptotic signal for B16 melanoma cells via ERK and caspase activation. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31794795&form=6&db=m TRPM2 ion channel is involved in the aggravation of cognitive impairment and down regulation of epilepsy threshold in pentylenetetrazole-induced kindling mice. therapeutic application,unassigned 1,0 2.4.2.30 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32353801&form=6&db=m Kaempferol protects against cadmium chloride-induced hippocampal damage and memory deficits by activation of silent information regulator 1 and inhibition of poly (ADP-Ribose) polymerase-1. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Meniere Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19221898&form=6&db=m Poly(ADP-ribose) polymerase-1 (PARP-1) longer alleles spanning the promoter region may confer protection to bilateral Meniere's disease. therapeutic application,unassigned 1,0 2.4.2.30 Meniere Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19863315&form=6&db=m Poly(ADP-ribose) polymerase-1 (PARP-1) longer alleles spanning the promoter region may confer protection to bilateral Meniere's disease. therapeutic application,unassigned 1,0 2.4.2.30 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8151353&form=6&db=m Expression of a functional endothelin (ETA) receptor in human meningiomas. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25118896&form=6&db=m Poly(ADP-ribose) polymerase-1 (PARP1) and p53 labelling index correlates with tumour grade in meningiomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 2.4.2.30 Meningitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21651918&form=6&db=m SNPs in DNA repair genes associated to meningitis and host immune response. ongoing research,unassigned 2,0 2.4.2.30 Meningitis, Bacterial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11807392&form=6&db=m Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Meningitis, Bacterial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15578971&form=6&db=m Advances in adjuvant therapy against acute bacterial meningitis. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Meningitis, Bacterial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25477764&form=6&db=m A putative role for homocysteine in the pathophysiology of acute bacterial meningitis in children. causal interaction,unassigned 1,0 2.4.2.30 Meningitis, Pneumococcal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11807392&form=6&db=m Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Meningococcal Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20016407&form=6&db=m Polymorphisms in PARP, IL1B, IL4, IL10, C1INH, DEFB1 and DEFA4 in meningococcal disease in three populations. diagnostic usage,unassigned 3,0 2.4.2.30 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19460788&form=6&db=m Taurolidine and oxidative stress: a rationale for local treatment of mesothelioma. therapeutic application,unassigned 2,0 2.4.2.30 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23301673&form=6&db=m PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1. causal interaction,unassigned 1,0 2.4.2.30 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23525508&form=6&db=m Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells. unassigned - 2.4.2.30 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24130923&form=6&db=m Hesperidin Induces Apoptosis by Inhibiting Sp1 and Its Regulatory Protein in MSTO-211H Cells. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28090191&form=6&db=m Blockage of epithelial to mesenchymal transition and upregulation of let 7b are critically involved in ursolic acid induced apoptosis in malignant mesothelioma cell. unassigned - 2.4.2.30 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28223140&form=6&db=m Reduced cell viability and apoptosis induction in human thyroid carcinoma and mesothelioma cells exposed to cidofovir. unassigned - 2.4.2.30 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28587822&form=6&db=m Initial evaluation of Cu-64 labeled PARPi-DOTA PET imaging in mice with mesothelioma. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28756516&form=6&db=m Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31447003&form=6&db=m Analysis of CCDC6 as a novel biomarker for the clinical use of PARP1 inhibitors in malignant pleural mesothelioma. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32004714&form=6&db=m Sensitivity of Mesothelioma Cells to PARP Inhibitors Is Not Dependent on BAP1 but Is Enhanced by Temozolomide in Cells With High-Schlafen 11 and Low-O6-methylguanine-DNA Methyltransferase Expression. causal interaction,unassigned 2,0 2.4.2.30 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32175161&form=6&db=m Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma. unassigned - 2.4.2.30 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33515503&form=6&db=m Rucaparib in patients with BAP1-deficient or BRCA1-deficient mesothelioma (MiST1): an open-label, single-arm, phase 2a clinical trial. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33777745&form=6&db=m BAP1-Altered Malignant Pleural Mesothelioma: Outcomes With Chemotherapy, Immune Check-Point Inhibitors and Poly(ADP-Ribose) Polymerase Inhibitors. therapeutic application,unassigned 4,0 2.4.2.30 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34443328&form=6&db=m Unsymmetric Cisplatin-Based Pt(IV) Conjugates Containing a PARP-1 Inhibitor Pharmacophore Tested on Malignant Pleural Mesothelioma Cell Lines. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28756516&form=6&db=m Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31447003&form=6&db=m Analysis of CCDC6 as a novel biomarker for the clinical use of PARP1 inhibitors in malignant pleural mesothelioma. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32175161&form=6&db=m Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma. unassigned - 2.4.2.30 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32429658&form=6&db=m Analysis of mutations of PARP1, RNF213, PAX8, KMT2C, MTRR in malignant mesothelioma of testicular tunica vaginalis testis. unassigned - 2.4.2.30 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32437065&form=6&db=m Anticarcinogenic effects of halofuginone on lung-derived cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33777745&form=6&db=m BAP1-Altered Malignant Pleural Mesothelioma: Outcomes With Chemotherapy, Immune Check-Point Inhibitors and Poly(ADP-Ribose) Polymerase Inhibitors. therapeutic application,unassigned 4,0 2.4.2.30 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34443328&form=6&db=m Unsymmetric Cisplatin-Based Pt(IV) Conjugates Containing a PARP-1 Inhibitor Pharmacophore Tested on Malignant Pleural Mesothelioma Cell Lines. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21459330&form=6&db=m PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22682224&form=6&db=m The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. ongoing research,unassigned 1,0 2.4.2.30 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26091343&form=6&db=m Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance. unassigned - 2.4.2.30 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27090903&form=6&db=m Poly(ADP-ribose) polymerases in aging - friend or foe? unassigned - 2.4.2.30 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28013023&form=6&db=m Metabolic roles of poly(ADP-ribose) polymerases. diagnostic usage,unassigned 3,0 2.4.2.30 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28664098&form=6&db=m Antagonistic crosstalk between SIRT1, PARP-1, and -2 in the regulation of chronic inflammation associated with aging and metabolic diseases. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30165350&form=6&db=m Inhibition of Poly(ADP-Ribose) Polymerase Increased Lipid Accumulation Through SREBP1 Modulation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30210648&form=6&db=m Oxidative-Nitrative Stress and Poly (ADP-Ribose) Polymerase Activation 3 Years after Pregnancy. causal interaction,unassigned 3,0 2.4.2.30 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28883796&form=6&db=m Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch. causal interaction,unassigned 1,0 2.4.2.30 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24780630&form=6&db=m Genotype-phenotype relationship in a child with 2.3 Mb de novo interstitial 12p13.33-p13.32 deletion. causal interaction,unassigned 1,0 2.4.2.30 Mitochondrial Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25788480&form=6&db=m Pharmacological NAD-Boosting Strategies Improve Mitochondrial Homeostasis in Human Complex I-Mutant Fibroblasts. unassigned - 2.4.2.30 Mitochondrial Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32324907&form=6&db=m Insights into the functional aspects of poly(ADP-ribose) polymerase-1 (PARP-1) in mitochondrial homeostasis in Dictyostelium discoideum. unassigned - 2.4.2.30 Monoclonal Gammopathy of Undetermined Significance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20644899&form=6&db=m Altered mRNA expression of telomere-associated genes in monoclonal gammopathy of undetermined significance and multiple myeloma. ongoing research,unassigned 3,0 2.4.2.30 Monoclonal Gammopathy of Undetermined Significance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29632340&form=6&db=m Targeting the MALAT1/PARP1/LIG3 complex induces DNA damage and apoptosis in multiple myeloma. diagnostic usage,unassigned 3,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15596295&form=6&db=m Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio. ongoing research,unassigned 2,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19585476&form=6&db=m Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21826155&form=6&db=m The Apoptotic Effect of the Hexane Extract of Rheum undulatum L. in Oral Cancer Cells through the Down-regulation of Specificity Protein 1 and Survivin. ongoing research,unassigned 3,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21963806&form=6&db=m Mechanism of sappanchalcone-induced growth inhibition and apoptosis in human oral cancer cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22753732&form=6&db=m Anticancer effects of eleven triterpenoids derived from Antrodia camphorata. unassigned - 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22882088&form=6&db=m Overexpression of chromatin assembly factor-1 p60, poly(ADP-ribose) polymerase 1 and nestin predicts metastasizing behaviour of oral cancer. therapeutic application,unassigned 1,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24166197&form=6&db=m MicroRNA-205 suppresses the oral carcinoma oncogenic activity via down-regulation of Axin-2 in KB human oral cancer cell. therapeutic application,unassigned 1,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24337492&form=6&db=m Licochalcone A induces apoptosis in KB human oral cancer cells via a caspase-dependent FasL signaling pathway. unassigned - 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25266202&form=6&db=m Tetrandrine induces apoptosis Via caspase-8, -9, and -3 and poly (ADP ribose) polymerase dependent pathways and autophagy through beclin-1/ LC3-I, II signaling pathways in human oral cancer HSC-3 cells. causal interaction,ongoing research,unassigned 3,3,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25903972&form=6&db=m In Vitro Assessment of the Anticancer Potential of Evodiamine in Human Oral Cancer Cell Lines. causal interaction,unassigned 1,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26808835&form=6&db=m Optical Imaging of PARP1 in Response to Radiation in Oral Squamous Cell Carcinoma. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26900125&form=6&db=m Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26927065&form=6&db=m Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27823618&form=6&db=m Polyphyllin G induces apoptosis and autophagy cell death in human oral cancer cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28965045&form=6&db=m Apoptosis induced by caffeic acid phenethyl ester in human oral cancer cell lines: Involvement of Puma and Bax activation. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29568920&form=6&db=m Oridonin induces apoptosis in oral squamous cell carcinoma probably through the generation of reactive oxygen species and the p38/JNK MAPK pathway. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30081204&form=6&db=m Preventive measures in oral cancer: An overview. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31768967&form=6&db=m PARP inhibitor Olaparib Enhances the Apoptotic Potentiality of Curcumin by Increasing the DNA Damage in Oral Cancer Cells through Inhibition of BER Cascade. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32636416&form=6&db=m Fluorescence-guided resection of tumors in mouse models of oral cancer. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32756347&form=6&db=m Methanol Extract of Usnea barbata Induces Cell Killing, Apoptosis, and DNA Damage against Oral Cancer Cells through Oxidative Stress. diagnostic usage,unassigned 1,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33373686&form=6&db=m PARP inhibitor Veliparib (ABT-888) enhances the anti-angiogenic potentiality of Curcumin through deregulation of NECTIN-4 in oral cancer: Role of nitric oxide (NO). causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34144488&form=6&db=m Olaparib enhances curcumin-mediated apoptosis in oral cancer cells by inducing PARP trapping through modulation of BER and chromatin assembly. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34356835&form=6&db=m Poly (ADP-Ribose) Polymerase Inhibitor, ABT888, Improved Cisplatin Effect in Human Oral Cell Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 MPTP Poisoning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10318960&form=6&db=m Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 MPTP Poisoning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12358742&form=6&db=m A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 2.4.2.30 MPTP Poisoning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640816&form=6&db=m SPATIAL AND FUNCTIONAL RELATIONSHIP BETWEEN POLY(ADP-RIBOSE) POLYMERASE-1 AND POLY(ADP-RIBOSE) GLYCOHYDROLASE IN THE BRAIN. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Mucositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25496187&form=6&db=m Efficacy of professionally-administered plaque removal with or without adjunctive measures for the treatment of peri-implant mucositis. A systematic review and meta-analysis. causal interaction,unassigned 3,0 2.4.2.30 Multiple Endocrine Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29650809&form=6&db=m [Molecular Targeted Therapies for Hereditary Cancer Syndrome]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Multiple Endocrine Neoplasia Type 2a http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29650809&form=6&db=m [Molecular Targeted Therapies for Hereditary Cancer Syndrome]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15574786&form=6&db=m Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20644899&form=6&db=m Altered mRNA expression of telomere-associated genes in monoclonal gammopathy of undetermined significance and multiple myeloma. ongoing research,unassigned 3,0 2.4.2.30 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20712901&form=6&db=m A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. unassigned - 2.4.2.30 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21917757&form=6&db=m Bortezomib-induced "BRCAness" sensitizes multiple myeloma cells to PARP inhibitors. therapeutic application,unassigned 1,0 2.4.2.30 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23045269&form=6&db=m Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma. unassigned - 2.4.2.30 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23762475&form=6&db=m Targeting poly (ADP-ribose) polymerase partially contributes to bufalin-induced cell death in multiple myeloma cells. ongoing research,unassigned 3,0 2.4.2.30 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23818927&form=6&db=m Decursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 and/or mTOR Pathways in Human Multiple Myeloma Cells. therapeutic application,unassigned 4,0 2.4.2.30 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24928009&form=6&db=m [Effect of PARP1 inhibitor PJ34 on multi-drug resistance in human multiple myeloma cell line and its relationship with FA/BRCA pathway]. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25351371&form=6&db=m PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26719576&form=6&db=m A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29467487&form=6&db=m Loss of heterozygosity as a marker of homologous repair deficiency in multiple myeloma: a role for PARP inhibition? causal interaction,unassigned 4,0 2.4.2.30 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29969371&form=6&db=m Cladribine in combination with entinostat synergistically elicits anti-proliferative/anti-survival effects on multiple myeloma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30247868&form=6&db=m Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14). causal interaction,unassigned 3,0 2.4.2.30 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30890936&form=6&db=m Research Progress on PARP14 as a Drug Target. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34048499&form=6&db=m Cytotoxicity of Gymnopilus purpureosquamulosus extracts on hematologic malignant cells through activation of the SAPK/JNK signaling pathway. ongoing research,unassigned 2,0 2.4.2.30 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34111425&form=6&db=m Inhibition of Pim-2 kinase by LT-171-861 promotes DNA damage and exhibits enhanced lethal effects with PARP inhibitor in multiple myeloma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34382902&form=6&db=m TRIM44 links the UPS to SQSTM1/p62-dependent aggrephagy and removing misfolded proteins. unassigned - 2.4.2.30 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15931673&form=6&db=m Poly(ADP-ribose) polymerase-1 activation in a primate model of multiple sclerosis. ongoing research,unassigned 3,0 2.4.2.30 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18500752&form=6&db=m Pertussis toxin induces angiogenesis in brain microvascular endothelial cells. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19628872&form=6&db=m PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20157013&form=6&db=m Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20811645&form=6&db=m Centrally administered pertussis toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an EAE mouse model. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22419424&form=6&db=m The regulatory effect of liuwei dihuang pills on cytokines in mice with experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23660634&form=6&db=m Pertussis toxin attenuates experimental autoimmune encephalomyelitis by upregulating neuronal vascular endothelial growth factor. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24486709&form=6&db=m Pertussis toxin modulates microglia and T cell profile to protect experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26724970&form=6&db=m The potential role of subclinical Bordetella Pertussis colonization in the etiology of multiple sclerosis. unassigned - 2.4.2.30 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31454809&form=6&db=m Neuroinflammation and B-Cell Phenotypes in Cervical and Lumbosacral Regions of the Spinal Cord in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin. unassigned - 2.4.2.30 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31897308&form=6&db=m PARP-1 deregulation in multiple sclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34310708&form=6&db=m Vascular and immunopathological role of Asymmetric Dimethylarginine (ADMA) in Experimental Autoimmune Encephalomyelitis. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Mumps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11520252&form=6&db=m Antibody responses of healthy infants to concurrent administration of a bivalent haemophilus influenzae type b-hepatitis B vaccine with diphtheria-tetanus-pertussis, polio and measles-mumps-rubella vaccines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Mumps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33928900&form=6&db=m Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019. diagnostic usage,unassigned 2,0 2.4.2.30 Murine Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31670405&form=6&db=m Parthanatos-associated proteins are stimulated intraocularly during development of experimental murine cytomegalovirus retinitis in mice with retrovirus-induced immunosuppression. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Muscle Hypotonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24780630&form=6&db=m Genotype-phenotype relationship in a child with 2.3 Mb de novo interstitial 12p13.33-p13.32 deletion. causal interaction,unassigned 1,0 2.4.2.30 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19390003&form=6&db=m Absence of Caspase-3 Protects Against Denervation Induced Skeletal Muscle Atrophy. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28131694&form=6&db=m Neer Award 2016: reduced muscle degeneration and decreased fatty infiltration after rotator cuff tear in a poly(ADP-ribose) polymerase 1 (PARP-1) knock-out mouse model. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34115723&form=6&db=m Repurposing of Clinically Approved Poly-(Adp-Ribose) Polymerase Inhibitors For The Therapy of Sepsis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20137830&form=6&db=m Telomere shortening is associated to TRF1 and PARP1 overexpression in Duchenne muscular dystrophy. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20137830&form=6&db=m Telomere shortening is associated to TRF1 and PARP1 overexpression in Duchenne muscular dystrophy. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Mycosis Fungoides http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29205518&form=6&db=m Therapeutic and prognostic significance of PARP-1 in advanced mycosis fungoides and Sezary syndrome. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Myelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15452194&form=6&db=m Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Myelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16184194&form=6&db=m IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis. unassigned - 2.4.2.30 Myelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17418876&form=6&db=m Inhibition of tyrosine kinase-mediated cellular signalling by Tyrphostins AG126 and AG556 modulates secondary damage in experimental spinal cord trauma. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Myelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19418318&form=6&db=m Effects of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in a mouse model of spinal cord injury. causal interaction,unassigned 1,0 2.4.2.30 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19407318&form=6&db=m Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23349304&form=6&db=m Microsatellite instability induced mutations in DNA repair genes Ctip and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors in myeloidmalignancies. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28212373&form=6&db=m Poly (ADP-ribose) polymerase 1 mRNA levels strongly correlate with the prognosis of myelodysplastic syndromes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,4 2.4.2.30 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29397193&form=6&db=m The poly (ADP ribose) polymerase inhibitor niraparib: Management of toxicities. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30877373&form=6&db=m Bone marrow PARP1 mRNA levels predict response to treatment with 5-azacytidine in patients with myelodysplastic syndrome. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31527467&form=6&db=m Cytotoxicity and Differentiating Effect of the Poly(ADP-Ribose) Polymerase Inhibitor Olaparib in Myelodysplastic Syndromes. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31667665&form=6&db=m Can synthetic lethality approach be used with DNA repair genes for primary and secondary MDS? ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32003046&form=6&db=m PARP1 V762A polymorphism affects the prognosis of myelodysplastic syndromes. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33347814&form=6&db=m Myelodysplastic syndrome and acute myeloid leukaemia in patients treated with PARP inhibitors: a safety meta-analysis of randomised controlled trials and a retrospective study of the WHO pharmacovigilance database. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4 2.4.2.30 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33347815&form=6&db=m PARP inhibitors-understanding the risk of myelodysplastic syndrome and acute myeloid leukaemia. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34529761&form=6&db=m Poly (ADP-ribose) polymerase-1 (PARP1) as a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10322503&form=6&db=m Poly (ADP-ribose) polymerase, nitric oxide and cell death. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10781287&form=6&db=m Isoflurane preconditions myocardium against infarction via activation of inhibitory guanine nucleotide binding proteins. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10949908&form=6&db=m Myocardial postischemic injury is reduced by polyADPripose polymerase-1 gene disruption. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11498530&form=6&db=m Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: long-term morphological and functional consequences. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11846617&form=6&db=m Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors. causal interaction,unassigned 3,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12381685&form=6&db=m Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12440774&form=6&db=m The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders. therapeutic application,unassigned 1,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14770035&form=6&db=m Activation of poly(ADP-ribose) polymerase in circulating leukocytes during myocardial infarction. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15054118&form=6&db=m Poly(ADP-ribose) polymerase contributes to the development of myocardial infarction in diabetic rats and regulates the nuclear translocation of apoptosis-inducing factor. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15561303&form=6&db=m Poly(ADP-ribose) polymerases: homology, structural domains and functions. Novel therapeutical applications. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15951400&form=6&db=m The role of Akt and mitogen-activated protein kinase systems in the protective effect of poly(ADP-ribose) polymerase inhibition in Langendorff perfused and in isoproterenol-damaged rat hearts. ongoing research,unassigned 2,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026319&form=6&db=m Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure. causal interaction,unassigned 4,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16716347&form=6&db=m PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16872633&form=6&db=m Local Administration of the Poly ADP-Ribose Polymerase (PARP) Inhibitor, PJ34 During Hindlimb Ischemia Modulates Skeletal Muscle Reperfusion Injury. causal interaction,unassigned 3,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17225870&form=6&db=m Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17430191&form=6&db=m Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17520094&form=6&db=m Poly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17689746&form=6&db=m Acute myocardial infarction induced increases in plasma tumor necrosis factor-alpha and interleukin-10 are associated with the activation of poly(ADP-ribose) polymerase of circulating mononuclear cell. causal interaction,diagnostic usage,unassigned 4,4,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18067605&form=6&db=m Inhibition of the activity of Poly(ADP-Ribose) Polymerase reduces heart ischemia/reperfusion injury via suppressing JNK mediated AIF translocation. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18535785&form=6&db=m A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of the TIMI 37 trial. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18782186&form=6&db=m Inhibition of the activity of poly (ADP-ribose) polymerase reduces heart ischaemia/reperfusion injury via suppressing JNK-mediated AIF translocation. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18809672&form=6&db=m Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18836068&form=6&db=m A novel and orally active poly(ADP-ribose) polymerase inhibitor, KR-33889 [2-[methoxycarbonyl(4-methoxyphenyl) methylsulfanyl]-1H-benzimidazole-4-carboxylic acid amide], attenuates injury in in vitro model of cell death and in vivo model of cardiac ischemia. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19567145&form=6&db=m Effects of 3-aminobenzamide on expressions of poly (ADP ribose) polymerase and apoptosis inducing factor in cardiomyocytes of rats with acute myocardial infarction. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21476963&form=6&db=m Poly (ADP-Ribose) Polymerase-1 (PARP-1) as Immune Regulator. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22266967&form=6&db=m Increased Poly (ADP-ribosyl)ation in Peripheral Leukocytes and the Reperfused Myocardium Tissue of Rats with Ischemia/Reperfusion Injury: Prevention by 3-Aminobenzamide Treatment. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22465010&form=6&db=m Reversible induction of PARP1 degradation by p53-inducible cis-imidazoline compounds. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22476980&form=6&db=m Natural Inhibitors of Poly(ADP-ribose) Polymerase-1. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23040216&form=6&db=m Relationship between NADPH oxidase p22phox C242T, PARP-1 Val762Ala polymorphisms, angiographically verified coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus. causal interaction,diagnostic usage,unassigned 3,1,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23165319&form=6&db=m Pretreatment of therapeutic cells with poly(ADP-ribose) polymerase inhibitor enhances their efficacy in an in vitro model of cell-based therapy in myocardial infarct. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28586070&form=6&db=m Protective effect of diethylcarbamazine inhibits NF-?B activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28656263&form=6&db=m Rho-kinase signaling pathway promotes the expression of PARP to accelerate cardiomyocyte apoptosis in ischemia/reperfusion. therapeutic application,unassigned 1,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29136949&form=6&db=m Minocycline improves cardiac function after myocardial infarction in rats by inhibiting activation of PARP-1. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29968072&form=6&db=m Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30041821&form=6&db=m PARP-1 inhibition attenuates cardiac fibrosis induced by myocardial infarction through regulating autophagy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31773708&form=6&db=m MicroRNA-577 inhibits cardiomyocyte apoptosis induced by myocardial infarction via targeting PARP1. therapeutic application,unassigned 2,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32160475&form=6&db=m MicroRNA-760-mediated low expression of DUSP1 impedes the protective effect of NaHS on myocardial ischemia-reperfusion injury. unassigned - 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33110392&form=6&db=m E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33168502&form=6&db=m [Poly(ADP-ribose) polymerases-1 inhibitor MRL-45696 alleviates DNA damage after myocardial ischemia-reperfusion in diabetic rats]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,2 2.4.2.30 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33580416&form=6&db=m Specific protein 1 inhibitor mithramycin A protects cardiomyocytes from myocardial infarction via interacting with PARP. therapeutic application,unassigned 2,0 2.4.2.30 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10949908&form=6&db=m Myocardial postischemic injury is reduced by polyADPripose polymerase-1 gene disruption. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11160908&form=6&db=m Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11498530&form=6&db=m Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: long-term morphological and functional consequences. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12039503&form=6&db=m Vasodilator signals from the ischemic myocardium are transduced to the coronary vascular wall by pertussis toxin-sensitive G proteins: a new experimental method for the analysis of the interaction between the myocardium and coronary vessels. unassigned - 2.4.2.30 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12570705&form=6&db=m Poly(ADP-ribose) polymerase inhibitors. causal interaction,unassigned 4,0 2.4.2.30 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12628304&form=6&db=m Development of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14571322&form=6&db=m Absence of poly(ADP-ribose)polymerase-1 alters nuclear factor-kappa B activation and gene expression of apoptosis regulators after reperfusion injury. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14670820&form=6&db=m Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15718920&form=6&db=m Inhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltration. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16357945&form=6&db=m Development of a miniaturized assay for the high-throughput screening program for poly(ADP-ribose) polymerase-1. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16480745&form=6&db=m In vitro effect of the potent poly(ADP-ribose) polymerase (PARP) inhibitor INO-1001 alone and in combination with aspirin, eptifibatide, tirofiban, enoxaparin or alteplase on haemostatic parameters. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17225870&form=6&db=m Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.4.2.30 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18836068&form=6&db=m A novel and orally active poly(ADP-ribose) polymerase inhibitor, KR-33889 [2-[methoxycarbonyl(4-methoxyphenyl) methylsulfanyl]-1H-benzimidazole-4-carboxylic acid amide], attenuates injury in in vitro model of cell death and in vivo model of cardiac ischemia. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18975057&form=6&db=m Prevalent role of Akt and ERK activation in cardioprotective effect of Ca(2+) channel- and beta-adrenergic receptor blockers. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20395771&form=6&db=m Therapeutic injection of PARP inhibitor INO-1001 preserves cardiac function in porcine myocardial ischemia and reperfusion without reducing infarct size. therapeutic application,unassigned 4,0 2.4.2.30 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30323296&form=6&db=m PARP1 promote autophagy in cardiomyocytes via modulating FoxO3a transcription. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Myocardial Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11498530&form=6&db=m Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: long-term morphological and functional consequences. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Myocardial Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12225730&form=6&db=m Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Myocardial Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12688429&form=6&db=m Beneficial effects of poly (ADP-ribose) polymerase inhibition against the reperfusion injury in heart transplantation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Myocardial Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14571322&form=6&db=m Absence of poly(ADP-ribose)polymerase-1 alters nuclear factor-kappa B activation and gene expression of apoptosis regulators after reperfusion injury. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Myocardial Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14670820&form=6&db=m Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Myocardial Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14770035&form=6&db=m Activation of poly(ADP-ribose) polymerase in circulating leukocytes during myocardial infarction. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Myocardial Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15718920&form=6&db=m Inhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltration. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Myocardial Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026318&form=6&db=m Role of nitrosative stress and poly(ADP-ribose) polymerase activation in myocardial reperfusion injury. causal interaction,unassigned 3,0 2.4.2.30 Myocardial Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391839&form=6&db=m Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Myositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30559337&form=6&db=m Interleukin-37 (IL-37) Suppresses Pertussis Toxin-Induced Inflammatory Myopathy in a Rat Model. causal interaction,ongoing research,unassigned 3,3,0 2.4.2.30 Myxoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11591716&form=6&db=m Poxvirus infection rapidly activates tyrosine kinase signal transduction. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9892179&form=6&db=m Reduced stability of regularly spliced but not alternatively spliced p53 protein in PARP-deficient mouse fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10557296&form=6&db=m Chromosomal aberrations in PARP(-/-) mice: genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA. causal interaction,unassigned 4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10557323&form=6&db=m Syncytiotrophoblastic giant cells in teratocarcinoma-like tumors derived from Parp-disrupted mouse embryonic stem cells. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10861865&form=6&db=m Differential susceptibility of normal and PARP knock-out mouse fibroblasts to proteasome inhibitors. causal interaction,unassigned 2,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11016956&form=6&db=m Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase. causal interaction,unassigned 4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11160908&form=6&db=m Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11359911&form=6&db=m DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11448989&form=6&db=m Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability. therapeutic application,unassigned 1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11544635&form=6&db=m Poly(ADP-ribose) polymerase-1 regulates the stability of the wild-type p53 protein. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11935067&form=6&db=m Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824873&form=6&db=m Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane. causal interaction,unassigned 3,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14630900&form=6&db=m Role of the activation of the nuclear enzyme poly(ADP-ribose) polymerase in the pathogenesis of periodontitis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15608683&form=6&db=m Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15709096&form=6&db=m Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15955622&form=6&db=m Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16338061&form=6&db=m Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16356201&form=6&db=m Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16436506&form=6&db=m PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres. causal interaction,unassigned 3,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17160013&form=6&db=m Poly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17560163&form=6&db=m Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17884996&form=6&db=m Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells. causal interaction,unassigned 4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17935742&form=6&db=m Changes in poly(ADP-ribose) level modulate the kinetics of DNA strand break rejoining. causal interaction,unassigned 3,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18242645&form=6&db=m Mutagenic effects of poly (ADP-ribose) polymerase-1 deficiency in transgenic mice. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18412984&form=6&db=m Transcriptional regulation by poly(ADP-ribose) polymerase-1 during T cell activation. causal interaction,unassigned 4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19188698&form=6&db=m A possible role for telomerase RNA and telomere length in global mitotic recombination. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19228791&form=6&db=m Poly(ADP-ribose) polymerase suppression protects rheumatoid synovial fibroblasts from Fas-induced apoptosis. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19247804&form=6&db=m Effect of PARP-1 deficiency on DNA damage and repair in human bronchial epithelial cells exposed to Benzo(a)pyrene. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19428377&form=6&db=m Role of Parp-1 in suppressing spontaneous deletion mutation in the liver and brain of mice at adolescence and advanced age. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19531481&form=6&db=m PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation. causal interaction,unassigned 4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19628872&form=6&db=m PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19741160&form=6&db=m Effects of PARP-1 deficiency on airway inflammatory cell recruitment in response to LPS or TNF: differential effects on CXCR2 ligands and Duffy antigen receptor for chemokines. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20171739&form=6&db=m Poly(ADP-ribose) polymerase-1 modulates interferon-gamma-inducible protein (IP)-10 expression in murine embryonic fibroblasts by stabilizing IP-10 mRNA. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20196134&form=6&db=m Poly (ADP-ribose) polymerase-1 deficiency does not affect ethylnitrosourea mutagenicity in liver and testis of lacZ transgenic mice. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20208002&form=6&db=m Increased Foxp3+ regulatory T cells in poly(ADP-Ribose) polymerase-1 deficiency. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20338998&form=6&db=m PARP-1 DEFICIENCY EXACERBATES DIET-INDUCED OBESITY IN MICE. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20434371&form=6&db=m Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20610652&form=6&db=m Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation. causal interaction,unassigned 1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20652015&form=6&db=m The BRCT domain of PARP-1 is required for immunoglobulin gene conversion. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21276008&form=6&db=m PARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21476963&form=6&db=m Poly (ADP-Ribose) Polymerase-1 (PARP-1) as Immune Regulator. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21613422&form=6&db=m Loss of poly(ADP-ribose) polymerase 1 attenuates renal fibrosis and inflammation during unilateral ureteral obstruction. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21911376&form=6&db=m Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family. causal interaction,unassigned 4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22437413&form=6&db=m Poly(ADP-ribose) polymerase 1 activation is required for cisplatin nephrotoxicity. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22535743&form=6&db=m Cytokine-mediated ?-cell damage in PARP-1-deficient islets. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23624507&form=6&db=m Parg deficiency confers radio-sensitization through enhanced cell death in mouse ES cells exposed to various forms of ionizing radiation. unassigned - 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23722590&form=6&db=m Role of poly(ADP-ribosyl)ation in a 'two-hit' model of hypoxia and oxidative stress in human A549 epithelial cells in vitro. causal interaction,unassigned 1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23956424&form=6&db=m B Cell-Intrinsic and -Extrinsic Regulation of Antibody Responses by PARP14, an Intracellular (ADP-Ribosyl)Transferase. causal interaction,unassigned 4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23957916&form=6&db=m Parp-1 deficiency in ES cells promotes invasive and metastatic lesions accompanying induction of trophoblast giant cells during tumorigenesis in uterine environment. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24319363&form=6&db=m Effects of PARP-1 deficiency on Th1 and Th2 cell differentiation. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24842055&form=6&db=m Modulation of Poly(ADP-Ribose) Polymerase-1 (PARP-1)-Mediated Oxidative Cell Injury by Ring Finger Protein 146 (RNF146) in Cardiac Myocytes. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26772194&form=6&db=m Poly(ADP-ribosyl)ation of Methyl CpG Binding Domain Protein 2 Regulates Chromatin Structure. causal interaction,unassigned 4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26912654&form=6&db=m Transcriptional reprogramming and resistance to colonic mucosal injury in Poly(ADP-ribose) polymerase 1 (PARP1)-deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27090907&form=6&db=m Parp1 deficiency confers defects in chromatin surveillance and remodeling during reprogramming by nuclear transfer. unassigned - 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27498558&form=6&db=m Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27624574&form=6&db=m PARP10 deficiency manifests by severe developmental delay and DNA repair defect. causal interaction,unassigned 4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27757983&form=6&db=m Poly(ADP-ribose) polymerase 1 deficiency increases nitric oxide production and attenuates aortic atherogenesis through downregulation of arginase II. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27796300&form=6&db=m PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27921172&form=6&db=m Erratum to: PARP10 deficiency manifests by severe developmental delay and DNA repair defect. causal interaction,unassigned 3,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28190220&form=6&db=m Erratum to: PARP10 deficiency manifests by severe developmental delay and DNA repair defect. causal interaction,unassigned 3,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28599495&form=6&db=m Investigation of the relative biological effectiveness and uniform isobiological killing effects of irradiation with a clinical carbon SOBP beam on DNA repair deficient CHO cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30867423&form=6&db=m Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31164820&form=6&db=m Effects of PARP-1 Deficiency and Histamine H4 Receptor Inhibition in an Inflammatory Model of Lung Fibrosis in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31551715&form=6&db=m Poly (ADP-Ribose) Polymerase-1 (PARP1) Deficiency and Pharmacological Inhibition by Pirenzepine Protects From Cisplatin-Induced Ototoxicity Without Affecting Antitumor Efficacy. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31569682&form=6&db=m Spontaneous Development of Dental Dysplasia in Aged Parp-1 Knockout Mice. causal interaction,unassigned 4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31924749&form=6&db=m Loss of PARP-1 attenuates diabetic arteriosclerotic calcification via Stat1/Runx2 axis. unassigned - 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31989039&form=6&db=m CRISPR/Cas9-mediated mutagenesis to validate the synergy between PARP1 inhibition and chemotherapy in BRCA1-mutated breast cancer cells. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33050515&form=6&db=m PARP1 Deficiency Reduces Tumour Growth by Decreasing E2F1 Hyperactivation: A Novel Mechanism in the Treatment of Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33570794&form=6&db=m PARP-1 involves in UVB-induced inflammatory response in keratinocytes and skin injury via regulation of ROS-dependent EGFR transactivation and p38 signaling. causal interaction,unassigned 4,0 2.4.2.30 nad+ adp-ribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34364219&form=6&db=m PARP1 deficiency protects against hyperglycemia-induced neointimal hyperplasia by upregulating TFPI2 activity in diabetic mice. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29490557&form=6&db=m Intralesional bleomycin A5 injection for the treatment of nasal polyps through inducing apoptosis. ongoing research,unassigned 2,0 2.4.2.30 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17214747&form=6&db=m Evidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17881119&form=6&db=m Protein expression and intracellular localization of prostate apoptosis response-4 (Par-4) are associated with apoptosis induction in nasopharyngeal carcinoma cell lines. ongoing research,unassigned 1,0 2.4.2.30 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18279607&form=6&db=m [Expression and Implication of Base Excision Repair Genes in Human Nasopharyngeal Carcinoma and Non-tumor Nasopharyngeal Tissues.] causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0 2.4.2.30 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23563481&form=6&db=m Poly(ADP-ribose) polymerase-1 regulates the mechanism of irradiation-induced CNE-2 human nasopharyngeal carcinoma cell autophagy and inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23979918&form=6&db=m Poly(ADP-ribose) polymerase 1 is overexpressed in nasopharyngeal carcinoma and its inhibition enhances radiotherapy. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.2.30 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25872765&form=6&db=m PARP-1 promotes autophagy via the AMPK/mTOR pathway in CNE-2 human nasopharyngeal carcinoma cells following ionizing radiation, while inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells. ongoing research,unassigned 2,0 2.4.2.30 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26408697&form=6&db=m CHM-1 Suppresses Formation of Cell Surface-associated GRP78-p85? Complexes, Inhibiting PI3K-AKT Signaling and Inducing Apoptosis of Human Nasopharyngeal Carcinoma Cells. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30717758&form=6&db=m Loss of NFBD1/MDC1 disrupts homologous recombination repair and sensitizes nasopharyngeal carcinoma cells to PARP inhibitors. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31452810&form=6&db=m Tanshinone IIA inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via p53-cyclin B1/CDC2. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2021948&form=6&db=m The relationship between motility factor receptor internalization and the lung colonization capacity of murine melanoma cells. unassigned - 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3652046&form=6&db=m Inhibition of lymphoma invasion and liver metastasis formation by pertussis toxin. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7911806&form=6&db=m Pertussis toxin inhibition of T-cell hybridoma invasion is reversed by manganese-induced activation of LFA-1. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11300326&form=6&db=m 5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients. ongoing research,unassigned 3,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11798872&form=6&db=m [Mechanism of the activation of extracellular signal-regulated kinase (ERK) in prostate cancer cell lines with different metastatic potential] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839981&form=6&db=m The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases. unassigned - 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17046715&form=6&db=m Poly(ADP-ribose)polymerase inhibition decreases angiogenesis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17616810&form=6&db=m The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20937877&form=6&db=m A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. causal interaction,unassigned 1,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21462088&form=6&db=m Garcinol Inhibits Cell Proliferation and Promotes Apoptosis in Pancreatic Adenocarcinoma Cells. ongoing research,unassigned 1,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21612407&form=6&db=m Lymph Node Metastasis of Gastric Cancer Is Associated with the Interaction Between Poly (ADP-Ribose) Polymerase 1 and Matrix Metallopeptidase 2. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22287547&form=6&db=m PARP-1 inhibition as a targeted strategy to treat Ewing's sarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22583356&form=6&db=m Down-regulation of Notch receptor signaling pathway induces caspase-dependent and caspase-independent apoptosis in lung squamous cell carcinoma cells. unassigned - 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24397478&form=6&db=m DNA damage response genes and the development of cancer metastasis. causal interaction,unassigned 4,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24436031&form=6&db=m Expression of PARP-1 and its active polymer PAR in prostate cancer and benign prostatic hyperplasia in Chinese patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25604534&form=6&db=m Deciphering the Insights of Poly(ADP-Ribosylation) in Tumor Progression. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25811737&form=6&db=m Genomic profiling in locally advanced and inflammatory breast cancer and its link to DCE-MRI and overall survival. diagnostic usage,unassigned 4,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26237679&form=6&db=m Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26633318&form=6&db=m Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26898760&form=6&db=m PARP1 enhances lung adenocarcinoma metastasis by novel mechanisms independent of DNA repair. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27643881&form=6&db=m Individual and Combined Expression of DNA Damage Response Molecules PARP1, ?H2AX, BRCA1, and BRCA2 Predict Shorter Survival of Soft Tissue Sarcoma Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27655641&form=6&db=m Uncovering synthetic lethal interactions for therapeutic targets and predictive markers in lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27895737&form=6&db=m High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28123587&form=6&db=m Analysis of molecular markers as predictive factors of lymph node involvement in breast carcinoma. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28714367&form=6&db=m PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28843522&form=6&db=m WITHDRAWN: An analysis of the gene interaction networks identifying the role of PARP1 in metastasis of non-small cell lung cancer. ongoing research,unassigned 1,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28916367&form=6&db=m Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,4 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28991194&form=6&db=m PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29152079&form=6&db=m An analysis of the gene interaction networks identifying the role of PARP1 in metastasis of non-small cell lung cancer. ongoing research,unassigned 2,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29511458&form=6&db=m SOX2 inhibits cell proliferation and metastasis, promotes apoptotic by downregulating CCND1 and PARP in gastric cancer. ongoing research,unassigned 3,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29515234&form=6&db=m PARP10 suppresses tumor metastasis through regulation of Aurora A activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30039287&form=6&db=m PARP3 inhibitors ME0328 and olaparib potentiate vinorelbine sensitization in breast cancer cell lines. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30353615&form=6&db=m Poly(ADP-Ribose) Polymerase Inhibition Sensitizes Colorectal Cancer-Initiating Cells to Chemotherapy. causal interaction,diagnostic usage,unassigned 4,4,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30834527&form=6&db=m Combination therapy with dacarbazine and statins improved the survival rate in mice with metastatic melanoma. unassigned - 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30864743&form=6&db=m PARG regulates the proliferation and differentiation of DCs and T cells via PARP/NF??B in tumour metastases of colon carcinoma. diagnostic usage,unassigned 2,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31303961&form=6&db=m PARP-1 inhibitor modulate ?-catenin signaling to enhance cisplatin sensitivity in cancer cervix. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31375040&form=6&db=m PARP Inhibitor Olaparib Use in a BRCA1-Positive Patient With Metastatic Triple-Negative Breast Cancer, Without the Initial Use of Platinum-Based Chemotherapy, Showing Significant Rapid Near Resolution of Large Liver Metastasis While Patient Experienced Gout-Like Symptoms. causal interaction,unassigned 1,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31438892&form=6&db=m Reduction of metastatic potential by inhibiting EGFR/Akt/p38/ERK signaling pathway and epithelial-mesenchymal transition after carbon ion exposure is potentiated by PARP-1 inhibition in non-small-cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31615091&form=6&db=m Topical 2'-Hydroxyflavanone for Cutaneous Melanoma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31685261&form=6&db=m Integration of Comprehensive Genomic Analysis and Functional Screening of Affected Molecular Pathways to Inform Cancer Therapy. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31815182&form=6&db=m Response to Olaparib in a Patient with Germline BRCA2 Mutation and Breast Cancer Leptomeningeal Carcinomatosis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31856867&form=6&db=m Mortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31903985&form=6&db=m ERCC1, PARP-1, and AQP1 as predictive biomarkers in colon cancer patients receiving adjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32221289&form=6&db=m Differential regulation of breast cancer bone metastasis by PARP1 and PARP2. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32640708&form=6&db=m Advancements in PARP1 Targeted Nuclear Imaging and Theranostic Probes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32774160&form=6&db=m Transgelin interacts with PARP1 in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33184404&form=6&db=m The diagnostic value of DNA repair gene in breast cancer metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33417305&form=6&db=m RNF114 suppresses metastasis through regulation of PARP10 in cervical cancer cells. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33417952&form=6&db=m PARP-1 induces EMT in non-small cell lung carcinoma cells via modulating the transcription factors Smad4, p65 and ZEB1. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33572647&form=6&db=m PARP1 as a Marker of an Aggressive Clinical Phenotype in Cutaneous Melanoma-A Clinical and an In Vitro Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33576344&form=6&db=m Identification of PARP-1 in cancer stem cells of gastrointestinal cancers: A preliminary study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33922595&form=6&db=m The PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34148137&form=6&db=m ATMIN Suppresses Metastasis by Altering the WNT-Signaling Pathway via PARP1 in MSI-High Colorectal Cancer. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34343132&form=6&db=m Targeting Gi/o protein-coupled receptor signaling blocks HER2-induced breast cancer development and enhances HER2-targeted therapy. ongoing research,unassigned 3,0 2.4.2.30 Neoplasm Micrometastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839981&form=6&db=m The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases. unassigned - 2.4.2.30 Neoplasm, Residual http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23564760&form=6&db=m Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasm, Residual http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32319232&form=6&db=m Major clinical research advances in gynecologic cancer in 2019. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasm, Residual http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33485358&form=6&db=m PARP inhibitor Olaparib overcomes Sorafenib resistance through reshaping the pluripotent transcriptome in hepatocellular carcinoma. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=188648&form=6&db=m Purification of poly(ADP-ribose) polymerase from Ehrlich ascites tumor cells by chromatography on DNA-agarose. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=211029&form=6&db=m Poly(ADP-ribose) polymerase from Ehrlich ascites tumor cells. Properties of the purified polymerase. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1374309&form=6&db=m [Enhancement of bleomycin or hyperthermia induced tumor cell damage by ADPRT inhibitor] ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1502187&form=6&db=m Induction of endonuclease-mediated apoptosis in tumor cells by C-nitroso-substituted ligands of poly(ADP-ribose) polymerase. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1540155&form=6&db=m The exposure of carcinogen-initiated primary neonatal rat hepatocytes to tumor promoters modulates both the transcripts and the enzymatic activity of nuclear poly(ADP-ribose) polymerase. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1837923&form=6&db=m Modulation of the cancer susceptibility measure, adenosine diphosphate ribosyl transferase (ADPRT), by differences in low-dose n-3 and n-6 fatty acids. diagnostic usage,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1847688&form=6&db=m Requirement of down-regulation of NAD+ ADP-ribosyltransferase for the interferon-gamma-induced activation process of murine macrophage tumor cells. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1904797&form=6&db=m Enhanced poly ADP-ribosylation in human leukemia lymphocytes and ovarian cancers. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1906188&form=6&db=m Baseline sister chromatid exchange in human cell lines with different levels of poly(ADP-ribose) polymerase. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1966810&form=6&db=m Tumor necrosis factor alpha 'primes' the platelet-activating factor-induced superoxide production by human neutrophils: possible involvement of G proteins. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2034793&form=6&db=m Radiosensitization of human T-cell leukemia by thymidine and 41.8 degrees C hyperthermia in vitro. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2117481&form=6&db=m A deletion linked to a poly(ADP-ribose) polymerase gene on chromosome 13q33-qter occurs frequently in the normal black population as well as in multiple tumor DNA. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2121341&form=6&db=m Oxidative stress, DNA repair, and cancer susceptibility. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2469642&form=6&db=m Interactive effects of pertussis toxin and the phorbol ester tumour promotor, phorbol dibutyrate, on T-lymphocyte mitogenesis and the expression of phenotypic determinants. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2473137&form=6&db=m Differential expression of Ia by murine keratinocytes and gut epithelium in response to recombinant gamma-interferon. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2482841&form=6&db=m The potentiation of the antitumor activity but not toxicity of bleomycin by 3-aminobenzamide. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2504504&form=6&db=m Adenosine diphosphate ribosyl transferase responses to a standardized dose of hydrogen peroxide in the mononuclear leukocytes of patients with a diagnosis of cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2941760&form=6&db=m Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2990674&form=6&db=m Radiosensitization effects of nicotinamide on malignant and normal mouse tissue. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2992825&form=6&db=m Poly(adenosine diphosphate-ribosylation) of nuclear matrix proteins in alkylating agent resistant and sensitive cell lines. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3017978&form=6&db=m Gonadotropin-releasing hormone activates a rapid Ca2+-independent phosphodiester hydrolysis of polyphosphoinositides in pituitary gonadotrophs. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3107559&form=6&db=m Phospholipase A2 activation in chemotactic peptide-stimulated HL60 granulocytes: synergism between diacylglycerol and Ca2+ in a protein kinase C-independent mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3132517&form=6&db=m A new ADP-ribosyltransferase in human serum: significance in cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3133126&form=6&db=m Inhibition of methylazoxymethanol acetate initiation of colon carcinogenesis in rats by treatment with the poly(ADP-ribose)polymerase inhibitor 3-aminobenzamide. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3133329&form=6&db=m Differential radiosensitization by the poly(ADP-ribose) transferase inhibitor 3-aminobenzamide in human tumor cells of varying radiosensitivity. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3204119&form=6&db=m Intracellular elevations of free calcium induced by activation of histamine H1 receptors in interphase and mitotic HeLa cells: hormone signal transduction is altered during mitosis. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6093766&form=6&db=m Pertussis toxin blocks the inhibitory effect of muscarinic cholinergic agonists on cyclic AMP accumulation and prolactin secretion in GH3 anterior-pituitary tumour cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6140258&form=6&db=m Possible role of poly(ADP-ribose) polymerase on the early stage of liver carcinogenesis by diethylnitrosamine in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6141934&form=6&db=m Human pancreatic tumor growth hormone (GH) - releasing factor and cyclic adenosine 3',5'- monophosphate evoke GH release from anterior pituitary cells: the effects of pertussis toxin, cholera toxin, forskolin, and cycloheximide. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6144544&form=6&db=m NAD[S], an NAD analogue with reduced susceptibility to phosphodiesterase. Chemical synthesis and enzymic properties. diagnostic usage,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7578423&form=6&db=m The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7703525&form=6&db=m Effect of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose) polymerase, on cultured tumor cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7784072&form=6&db=m Co-regulated expression of dbl and poly(ADP-ribose) polymerase in Ewing's sarcoma cells and dbl-transformed NIH3T3 fibroblasts. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7935983&form=6&db=m 3-Aminobenzamide delays rejoining of DNA strand breaks in gamma-irradiated lymphocytes from patients with breast cancer and not cervical cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8082877&form=6&db=m Augmentation of tumor necrosis factor-alpha-induced monocytic differentiation of a myelomonocytic leukemia (WEHI-3B JCS) by pertussis toxin. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8147867&form=6&db=m Cell death protection by 3-aminobenzamide: impairment of cytoskeleton function in human NK cell-mediated killing. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8217790&form=6&db=m The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8261576&form=6&db=m Reversal of acquired cisplatin resistance by nicotinamide in vitro and in vivo. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8264421&form=6&db=m Production and release of tumor necrosis factor alfa, interleukin-1B and interleukin-6 by human mononuclear leukocytes stimulated with pertussis toxin. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8392842&form=6&db=m Autocrine motility factor is a growth factor. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8429889&form=6&db=m Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8434580&form=6&db=m A duplicated region is responsible for the poly(ADP-ribose) polymerase polymorphism, on chromosome 13, associated with a predisposition to cancer. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8527492&form=6&db=m Reversion of malignant phenotype by 5-iodo-6-amino-1,2-benzopyrone a non-covalently binding ligand of poly(ADP-ribose) polymerase. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8612815&form=6&db=m Nitric oxide induced poly(ADP-ribose) polymerase cleavage in RAW 264.7 macrophage apoptosis is blocked by Bcl-2. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8619857&form=6&db=m Bcl-2 overexpression blocks activation of the death protease CPP32/Yama/apopain. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647863&form=6&db=m ADP-ribosylation of the G protein Rho inhibits integrin regulation of tumor cell growth. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8665517&form=6&db=m Reduction of tumor hypoxia and inhibition of DNA repair by nicotinamide after irradiation of SCCVII murine tumors and normal tissues. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8694840&form=6&db=m ADP-ribosylation of wild-type p53 in vitro: binding of p53 protein to specific p53 consensus sequence prevents its modification. ongoing research,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8784077&form=6&db=m Coupling of gonadotropin-releasing hormone receptor to Gi protein in human reproductive tract tumors. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8880892&form=6&db=m Endotoxin tolerance impairs a pertussis-toxin-sensitive G-protein regulating tumour necrosis factor release by macrophages from tumour-bearing rats. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8898976&form=6&db=m Combination effects of poly(ADP-ribose) polymerase inhibitors and DNA-damaging agents in ovarian tumor cell lines--with special reference to cisplatin. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8940132&form=6&db=m Specific cleavage of alpha-fodrin during Fas- and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1beta-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8948442&form=6&db=m ADP-ribosylation of the GTP-binding protein RhoA blocks cytoplasmic division in human myelomonocytic cells. ongoing research,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8955177&form=6&db=m Preferential involvement of Go and Gz proteins in mediating rat natural killer cell lysis of allogeneic and tumor target cells. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8999887&form=6&db=m Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9111197&form=6&db=m Functional overexpression of human poly(ADP-ribose) polymerase in transfected rat tumor cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9136078&form=6&db=m Protein kinases A and C positively regulate G protein-dependent activation of phosphatidylinositol-specific phospholipase C by tumor necrosis factor-alpha in MC3T3-E1 osteoblasts. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9295059&form=6&db=m Poly(ADP-ribose) polymerase in human breast cancer: a case-control analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9308963&form=6&db=m PARP is important for genomic stability but dispensable in apoptosis. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9521710&form=6&db=m Inhibitor and NAD+ binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9541584&form=6&db=m Activation of caspase-3-like enzymes in non-apoptotic T cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9565608&form=6&db=m Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9616774&form=6&db=m Whole-body hyperthermia and ADPRT inhibition in experimental treatment of brain tumors. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9624143&form=6&db=m Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9707099&form=6&db=m Effects of poly(ADP-ribose) polymerase inhibition on cell death and chromosome damage induced by VP16 and bleomycin. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9746596&form=6&db=m Intestinal secretory factor released by macrophages stimulated with Clostridium difficile toxin A: role of interleukin 1beta. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9806612&form=6&db=m Monitoring and signaling of radiation-induced damage in mammalian cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9816283&form=6&db=m Poly(ADP-ribose) polymerase gene expression status and genomic instability in human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9849882&form=6&db=m Selective involvement of caspase-3 in ceramide induced apoptosis in AK-5 tumor cells. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9855679&form=6&db=m Poly(ADP-ribose) polymerase, a potential target for drugs: Cellular regulatory role of the polymer and the polymerase protein mediated by catalytic and macromolecular colligative actions (Review). therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9890562&form=6&db=m Induction of Bax protein and degradation of lamin A during p53-dependent apoptosis induced by chemotherapeutic agents in human cancer cell lines. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9892179&form=6&db=m Reduced stability of regularly spliced but not alternatively spliced p53 protein in PARP-deficient mouse fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9915771&form=6&db=m Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10048316&form=6&db=m Phthalocyanine 4 (Pc 4) photodynamic therapy of human OVCAR-3 tumor xenografts. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10226574&form=6&db=m Extract of Solanum muricatum (Pepino/CSG) inhibits tumor growth by inducing apoptosis. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10326863&form=6&db=m Cleavage of poly(ADP-ribose) transferase during p53-independent apoptosis in rat liver after treatment with N-nitrosomorpholine and cyproterone acetate. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10330277&form=6&db=m CD40- and HLA-DR-mediated cell death pathways share a lot of similarities but differ in their use of ADP-ribosyltransferase activities. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10373561&form=6&db=m Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10435618&form=6&db=m Regulation of the human poly(ADP-ribose) polymerase promoter by the ETS transcription factor. causal interaction,diagnostic usage,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10438458&form=6&db=m Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10475354&form=6&db=m Intravesical therapy with pertussis toxin before radical cystectomy in patients with bladder cancer: a Phase I study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10493527&form=6&db=m Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10500802&form=6&db=m Effects of PARP inhibition on drug and Fas-induced apoptosis in leukaemic cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10527563&form=6&db=m Induction of CD4(+) and CD8(+) Bordetella pertussis toxin subunit S1 specific T cells by immunization with synthetic peptides. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10557323&form=6&db=m Syncytiotrophoblastic giant cells in teratocarcinoma-like tumors derived from Parp-disrupted mouse embryonic stem cells. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10597252&form=6&db=m VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10597301&form=6&db=m Overexpression of dominant negative PARP interferes with tumor formation of HeLa cells in nude mice: evidence for increased tumor cell apoptosis in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10601269&form=6&db=m Survival and proliferation of cells expressing caspase-uncleavable Poly(ADP-ribose) polymerase in response to death-inducing DNA damage by an alkylating agent. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10630309&form=6&db=m Increased cell-surface receptor expression on U-937 cells induced by 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10666341&form=6&db=m Cleavage of Poly(ADP-ribose) polymerase measured in situ in individual cells: relationship to DNA fragmentation and cell cycle position during apoptosis. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10706869&form=6&db=m Tumor-induced apoptosis of T lymphocytes: elucidation of intracellular apoptotic events. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10744766&form=6&db=m Poly(ADP-ribose) polymerase is a B-MYB coactivator. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10814955&form=6&db=m Poly(ADP-ribose) polymerase in DNA damage-response pathway: implications for radiation oncology. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10815928&form=6&db=m Photodynamic therapy with the phthalocyanine photosensitizer Pc 4 of SW480 human colon cancer xenografts in athymic mice. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10914735&form=6&db=m Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10946322&form=6&db=m Adenoviral-mediated transfer of the TNF-related apoptosis-inducing ligand/Apo-2 ligand gene induces tumor cell apoptosis. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10960365&form=6&db=m Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11016422&form=6&db=m Lupus susceptibility genes on human chromosome 1. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11016956&form=6&db=m Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11029498&form=6&db=m X-ray-induced damage repair in exponentially growing and growth arrested confluent poly(adenosine diphosphate-ribose) polymerase-deficient V79 chinese hamster cell line. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11062748&form=6&db=m Modulation of the antiproliferative activity of anticancer drugs in hematopoietic tumor cell lines by the poly(ADP-ribose) polymerase inhibitor 6(5H)-phenanthridinone. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11063605&form=6&db=m Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11097224&form=6&db=m Selenium effects on prostate cell growth. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11123719&form=6&db=m Expression of poly(ADP-ribose) polymerase and distribution of poly(ADP-ribosyl)ation in glioblastoma and in a glioma multicellular tumour spheroid model. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11175318&form=6&db=m Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11300326&form=6&db=m 5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11308266&form=6&db=m Cleavage of caspases-1, -3, -6, -8 and -9 substrates by proteases in skeletal muscles from mice undergoing cancer cachexia. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11323103&form=6&db=m Methylation of the hMLH1, p16, and MDR1 genes in colorectal carcinoma: associations with clinicopathological features. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11359911&form=6&db=m DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11369647&form=6&db=m Activation of the formyl peptide receptor by the HIV-derived peptide T-20 suppresses interleukin-12 p70 production by human monocytes. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11376692&form=6&db=m Involvement of poly(ADP-ribose) polymerase in trophoblastic cell differentiation during tumorigenesis. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11403964&form=6&db=m Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11423906&form=6&db=m Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11432840&form=6&db=m Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11445281&form=6&db=m Pertussis toxin-induced hyperacute autoimmune encephalomyelitis in Lewis rats is correlated with increased expression of inducible nitric oxide synthase and tumor necrosis factor alpha. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11461900&form=6&db=m Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase in an amplification phase of tumor necrosis factor-induced apoptosis. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11471486&form=6&db=m Apoptosis-related gene and protein expression in human lymphoma xenografts (Raji) after low dose rate radiation using 67Cu-2IT-BAT-Lym-1 radioimmunotherapy. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11474885&form=6&db=m [Cytotoxicity of beta-lapachone, an naphthoquinone with possible therapeutic use] unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11477085&form=6&db=m Regulation of p53 sequence-specific DNA-binding by covalent poly(ADP-ribosyl)ation. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11485385&form=6&db=m Differential induction of apoptosis and MAP kinase signaling by mitochondrial toxicants in drug-sensitive compared to drug-resistant B-lineage lymphoid cell lines. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11498783&form=6&db=m Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11533241&form=6&db=m Human MCF10A mammary epithelial cells undergo apoptosis following actin depolymerization that is independent of attachment and rescued by Bcl-2. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11544635&form=6&db=m Poly(ADP-ribose) polymerase-1 regulates the stability of the wild-type p53 protein. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11550977&form=6&db=m Granulocyte-macrophage colony stimulating factor activates proteoglycan, type II collagen, and cAMP production by rat articular chondrocytes through specific binding sites. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11559556&form=6&db=m Taurolidine: cytotoxic and mechanistic evaluation of a novel antineoplastic agent. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11641261&form=6&db=m Additive activation of hepatic NF-kappaB by ethanol and hepatitis B protein X (HBX) or HCV core protein: involvement of TNF-alpha receptor 1-independent and -dependent mechanisms. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11716501&form=6&db=m TCDD-inducible poly(ADP-ribose) polymerase: a novel response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11723234&form=6&db=m Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11746275&form=6&db=m Baicalin is a major component of PC-SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrest. diagnostic usage,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11772428&form=6&db=m Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11781113&form=6&db=m Poly(ADP-ribose) polymerase: a guardian angel protecting the genome and suppressing tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11785971&form=6&db=m Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase-1 in sensitization of fibroblasts to tumor necrosis factor-induced apoptosis. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11836632&form=6&db=m Photodynamic therapy induced Fas-mediated apoptosis in human carcinoma cells. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11853696&form=6&db=m Anti-cancer action of 4-iodo-3-nitrobenzamide in combination with buthionine sulfoximine: inactivation of poly(ADP-ribose) polymerase and tumor glycolysis and the appearance of a poly(ADP-ribose) polymerase protease. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11867628&form=6&db=m p53 Activation by nitric oxide involves down-regulation of Mdm2. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11877304&form=6&db=m Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11935214&form=6&db=m Apoptotic and genotoxic effects of a methyl sulfonate ester that selectively generates N3-methyladenine and poly(ADP-ribose) polymerase inhibitors in normal peripheral blood lymphocytes. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11948969&form=6&db=m Insulin-like growth factor binding protein-3 induces early apoptosis in malignant prostate cancer cells and inhibits tumor formation in vivo. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12011977&form=6&db=m Hypericin induced death receptor-mediated apoptosis in photoactivated tumor cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12019179&form=6&db=m Rescue of hypoxia-inducible factor-1alpha-deficient tumor growth by wild-type cells is independent of vascular endothelial growth factor. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12082628&form=6&db=m TERT regulates cell survival independent of telomerase enzymatic activity. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12102760&form=6&db=m Intracellular trafficking and surface expression of SS-A (Ro), SS-B (La), poly(ADP-ribose) polymerase and alpha-fodrin autoantigens during apoptosis in human salivary gland cells induced by tumour necrosis factor-alpha. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12161427&form=6&db=m Transcriptional repressor activating transcription factor 3 protects human umbilical vein endothelial cells from tumor necrosis factor-alpha-induced apoptosis through down-regulation of p53 transcription. diagnostic usage,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12164482&form=6&db=m Modulating poly (ADP-ribose) polymerase activity: potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12168847&form=6&db=m Tumor necrosis factor-alpha induces apoptosis associated with poly(ADP-ribose) polymerase cleavage in HT-29 colon cancer cells. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12188916&form=6&db=m Chromatin (dis)organization and cancer: BUR-binding proteins as biomarkers for cancer. causal interaction,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12237842&form=6&db=m Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12351627&form=6&db=m Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12406551&form=6&db=m Induction of poly(ADP-ribose) polymerase-1 cleavage by antitumor triptycene bisquinones in wild-type and daunorubicin-resistant HL-60 cell lines. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12408707&form=6&db=m Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12414904&form=6&db=m Characterization of human chorionic gonadotropin as a novel angiogenic factor. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12414956&form=6&db=m The human papillomavirus type 16 E5 protein impairs TRAIL- and FasL-mediated apoptosis in HaCaT cells by different mechanisms. diagnostic usage,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12455052&form=6&db=m Tumor regression mechanisms by IL-13 receptor-targeted cancer therapy involve apoptotic pathways. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12460917&form=6&db=m Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12468322&form=6&db=m Lysophosphatidic acid induces focal adhesion assembly through Rho/Rho-associated kinase pathway in human ovarian cancer cells. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12471617&form=6&db=m Wnt-5a and G-protein signaling are required for collagen-induced DDR1 receptor activation and normal mammary cell adhesion. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12481422&form=6&db=m Intratumor administration of interleukin 13 receptor-targeted cytotoxin induces apoptotic cell death in human malignant glioma tumor xenografts. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12488552&form=6&db=m Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12499423&form=6&db=m Poly(ADP-ribose) polymerase and cancer: in relation to the lectures presented by Dr Gilbert de Murcia. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12516964&form=6&db=m 2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]-propionic acid (XK469) inhibition of topoisomerase IIbeta is not sufficient for therapeutic response in human Waldenstrom's macroglobulinemia xenograft model. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12525876&form=6&db=m Synergistic anticancer action of reversibly and irreversibly acting ligands of poly (ADP-ribose) polymerase. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12528889&form=6&db=m The role of nitric oxide in cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12628304&form=6&db=m Development of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12642583&form=6&db=m Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12675907&form=6&db=m Poly(ADP-ribose) polymerase-1 activity promotes NF-kappaB-driven transcription and microglial activation: implication for neurodegenerative disorders. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12704785&form=6&db=m Central and carboxy-terminal regions of human p53 protein are essential for interaction and complex formation with PARP-1. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12707040&form=6&db=m Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12729565&form=6&db=m Parp1-deficiency induces differentiation of ES cells into trophoblast derivatives. ongoing research,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12820363&form=6&db=m The tumor metabolome. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824873&form=6&db=m Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12829019&form=6&db=m PARP-1, a determinant of cell survival in response to DNA damage. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12881518&form=6&db=m Suppression of NF-kappa B survival signaling by nitrosylcobalamin sensitizes neoplasms to the anti-tumor effects of Apo2L/TRAIL. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12898523&form=6&db=m Phosphorylation regulates the interaction and complex formation between wt p53 protein and PARP-1. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12907654&form=6&db=m Apoptosis induction in prostate cancer cells and xenografts by combined treatment with Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand and CPT-11. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12957467&form=6&db=m Recombinant IFN-alpha2b treatment activates poly (ADPR) polymerase-1 (PARP-1) in KB cancer cells. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12957613&form=6&db=m Cardiomyocyte death in patients with end-stage heart failure before and after support with a left ventricular assist device: low incidence of apoptosis despite ubiquitous mediators. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12960163&form=6&db=m Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12960734&form=6&db=m Antitumor triptycene bisquinones: a novel synthetic class of dual inhibitors of DNA topoisomerase I and II activities. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14522884&form=6&db=m A peptide with three hyaluronan binding motifs inhibits tumor growth and induces apoptosis. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14557488&form=6&db=m Enhanced polyadenosine diphosphate-ribosylation in gonadotropin-releasing hormone agonist-treated uterine leiomyoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566854&form=6&db=m Poly(ADP-ribose) and carcinogenesis. ongoing research,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14578157&form=6&db=m Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14594650&form=6&db=m Poly ADP-ribose polymerase (PARP) inhibitors transiently protect leukemia cells from alkylating agent induced cell death by three different effects. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14614022&form=6&db=m Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14626669&form=6&db=m Activation of poly(adenosine diphosphate-ribose) polymerase in mouse tumors treated by photodynamic therapy. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14642390&form=6&db=m Inhibition of poly(ADP-RIBOSE) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14646226&form=6&db=m Response of DNA repair enzymes in murine fibrosarcoma, lymphosarcoma and ascites cells following gamma irradiation. diagnostic usage,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14662759&form=6&db=m Overexpression of MEKK3 confers resistance to apoptosis through activation of NFkappaB. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14709739&form=6&db=m Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14739238&form=6&db=m Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14751510&form=6&db=m PARP-1, PARP-2, and the cellular response to low doses of ionizing radiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14871845&form=6&db=m Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14871963&form=6&db=m Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15010879&form=6&db=m Glycerol enhances CDDP-induced growth inhibition of thyroid anaplastic carcinoma tumor carrying mutated p53 gene. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15037204&form=6&db=m Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fas signaling. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15041999&form=6&db=m Evidence for tight coupling of Gi protein-mediated lysophosphatidic acid receptor to stimulated cytokine production in ovarian cancer cell. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15077172&form=6&db=m Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15109627&form=6&db=m Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15134218&form=6&db=m DNA-binding properties of poly(ADP-ribose) polymerase: a target for anticancer therapy. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15142883&form=6&db=m Apoptotic resistance to ionizing radiation in pediatric B-precursor acute lymphoblastic leukemia frequently involves increased NF-kappaB survival pathway signaling. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15158095&form=6&db=m Stromal cell protection of B-lineage acute lymphoblastic leukemic cells during chemotherapy requires active Akt. ongoing research,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15162024&form=6&db=m DNA repair factors and telomere-chromosome integrity in mammalian cells. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15163544&form=6&db=m Structurally related antitumor effects of flavanones in vitro and in vivo: involvement of caspase 3 activation, p21 gene expression, and reactive oxygen species production. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15254147&form=6&db=m Inhibition of poly(ADP-ribose) polymerase prevents allergen-induced asthma-like reaction in sensitized Guinea pigs. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15286704&form=6&db=m Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15302869&form=6&db=m Critical role of the automodification of poly(ADP-ribose) polymerase-1 in nuclear factor-kappaB-dependent gene expression in primary cultured mouse glial cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15328205&form=6&db=m Antiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15346059&form=6&db=m Bisphosphonates may reduce recurrence in giant cell tumor by inducing apoptosis. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15375506&form=6&db=m Expression of poly(ADP-ribose) polymerase in human hepatocellular carcinoma and analysis of biopsy specimens obtained under sonographic guidance. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15385543&form=6&db=m Myocardial cell death and regeneration during progression of cardiac hypertrophy to heart failure. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15486061&form=6&db=m Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15505427&form=6&db=m Sensitization by glycerol for CDDP-therapy against human cultured cancer cells and tumors bearing mutated p53 gene. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15545229&form=6&db=m Mechanisms of naringenin-induced apoptotic cascade in cancer cells: involvement of estrogen receptor alpha and beta signalling. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15545322&form=6&db=m Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15561303&form=6&db=m Poly(ADP-ribose) polymerases: homology, structural domains and functions. Novel therapeutical applications. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15604259&form=6&db=m Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15604274&form=6&db=m Insulin regulates cleavage of procaspase-9 via binding of X chromosome-linked inhibitor of apoptosis protein in HT-29 cells. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15621735&form=6&db=m Aberrant morphology, proliferation, and apoptosis of B-cell chronic lymphocytic leukemia cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15637586&form=6&db=m Poly(ADP-ribose): a co-regulator of DNA methylation? unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15645126&form=6&db=m Brain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15709096&form=6&db=m Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15743666&form=6&db=m Poly(ADP-ribose) polymerases: managing genome stability. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15789364&form=6&db=m Oral treatment of the TRAMP mice with doxazosin suppresses prostate tumor growth and metastasis. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15822818&form=6&db=m Comparative status of activated ERK1/2 and PARP cleavage in human gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15829966&form=6&db=m Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15836799&form=6&db=m PARP inhibitors for cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15846298&form=6&db=m HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15858615&form=6&db=m Antimyeloma activity of two novel N-substituted and tetraflourinated thalidomide analogs. diagnostic usage,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15867241&form=6&db=m Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,2 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15868402&form=6&db=m Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15871945&form=6&db=m Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911328&form=6&db=m PARP-1 inhibition to treat cancer, ischemia, inflammation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911329&form=6&db=m Mediation of cell death by poly(ADP-ribose) polymerase-1. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911331&form=6&db=m Chemopotentiation by PARP inhibitors in cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911339&form=6&db=m Clinical perspectives of PARP inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15956254&form=6&db=m Sapphyrins induce apoptosis in hematopoietic tumor-derived cell lines and show in vivo antitumor activity. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15981920&form=6&db=m HPMA copolymer-bound doxorubicin induces apoptosis in human ovarian carcinoma cells by a Fas-independent pathway. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15986430&form=6&db=m Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15990392&form=6&db=m Geranylgeranyl transferase inhibition stimulates anti-melanoma immune response through MHC Class I and costimulatory molecule expression. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15995937&form=6&db=m PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16033847&form=6&db=m CHIR-258: a potent inhibitor of FLT3 kinase in experimental tumor xenograft models of human acute myelogenous leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16077192&form=6&db=m Physiological ageing: role of p53 and PARP-1 tumor suppressors in the regulation of terminal senescence. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16082177&form=6&db=m Absence of Specific Cell Killing of the BRCA2-Deficient Human Cancer Cell Line CAPAN1 by Poly(ADP-ribose) Polymerase Inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16082409&form=6&db=m Advantage of a baculovirus expression system for protein-protein interaction studies. Involvement of posttranslational phosphorylation in the interaction between wt p53 protein and poly(ADP-ribose) polymerase-1. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16084940&form=6&db=m Poly(adenosine diphosphate-ribose) polymerase 1 expression in malignant melanomas from photoexposed areas of the head and neck region. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16123586&form=6&db=m Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16154385&form=6&db=m Targeting poly(ADP-ribosyl)ation: a promising approach in cancer therapy. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16170028&form=6&db=m Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16181138&form=6&db=m Poly(ADP-ribose)polymerase inhibition - where now? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16204055&form=6&db=m Increased susceptibility of vault poly(ADP-ribose) polymerase-deficient mice to carcinogen-induced tumorigenesis. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16251802&form=6&db=m BRCA2-Deficient CAPAN-1 Cells are Extremely Sensitive to the Inhibition of Poly (ADP-Ribose) Polymerase: An Issue of Potency. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16255377&form=6&db=m [Fermented wheat germ extract in the supportive therapy of colorectal cancer] causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16287996&form=6&db=m Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16291393&form=6&db=m Inhibition of tyrosine-kinase-mediated cellular signaling by tyrphostins AG 126 and AG556 modulates murine experimental acute pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16322354&form=6&db=m Induction of adenosine A1 receptor expression by pertussis toxin via an adenosine 5'-diphosphate ribosylation-independent pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16338061&form=6&db=m Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16356201&form=6&db=m Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16385577&form=6&db=m Rho/ROCK pathway as a target of tumor therapy. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391829&form=6&db=m Quantitative correlation between cellular proliferation and nuclear poly (ADP-ribose) polymerase (PARP-1). causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16421589&form=6&db=m The telomeric PARP, tankyrases, as targets for cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16434901&form=6&db=m Increased Occurrence of Caspase-Dependent Apoptosis in Unfavorable Neuroblastomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16446354&form=6&db=m Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16472553&form=6&db=m 15-Lipoxygenase-1 induced by interleukin-4 mediates apoptosis in oral cavity cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16543917&form=6&db=m Suppression of tumor growth using a recombinant adenoviral vector carrying the dominant-negative mutant gene Survivin-D53A in a nude mice model. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16546970&form=6&db=m Radiosensitization by the poly(ADP-ribose) polymerase inhibitor 4-amino-1,8-naphthalimide is specific of the S phase of the cell cycle and involves arrest of DNA synthesis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16564042&form=6&db=m Secretory phospholipase A(2) induces apoptosis through TNF-alpha and cytochrome c-mediated caspase cascade in murine macrophage RAW 264.7 cells. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16572308&form=6&db=m Cloricromene, a coumarine derivative, reduced the development of periodontitis in rats. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16610232&form=6&db=m Nickel(II) affects poly(ADP-ribose) polymerase-mediated DNA repair in normal and cancer cells. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16640785&form=6&db=m Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16740713&form=6&db=m Inhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16753340&form=6&db=m Inhibition of poly(ADP-ribose) polymerase in cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16777983&form=6&db=m An oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16787355&form=6&db=m Poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide enhances apoptosis induction by platinum complexes in cisplatin-resistant tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16800886&form=6&db=m Cancer during pregnancy alters the activity of rat placenta and enhances the expression of cleaved PARP, cytochrome-c and caspase 3. causal interaction,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809031&form=6&db=m Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809434&form=6&db=m Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16810332&form=6&db=m The Inhibition and Treatment of Breast Cancer with Poly (ADP-ribose) Polymerase (PARP-1) Inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16827123&form=6&db=m Inhibition of neuroblastoma xenograft growth by Hsp90 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16828564&form=6&db=m Inhibition of T cell homing by down-regulation of CD62L and the induction of a Th-2 response as a method to prevent acute allograft rejection in mice. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16865091&form=6&db=m Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16892389&form=6&db=m Poly(ADP-Ribose)-Polymerase-Catalyzed Hydrolysis of NAD(+): QM/MM Simulation of the Enzyme Reaction. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16906222&form=6&db=m PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers? causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16912188&form=6&db=m Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16920718&form=6&db=m Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16982753&form=6&db=m {beta}2-Microglobulin Is a Signaling and Growth-Promoting Factor for Human Prostate Cancer Bone Metastasis. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16982767&form=6&db=m Anticancer Activity of BIM-46174, a New Inhibitor of the Heterotrimeric G{alpha}/G{beta}{gamma} Protein Complex. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16985072&form=6&db=m Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways. causal interaction,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17007818&form=6&db=m Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17035597&form=6&db=m Down-regulation of inhibitor of apoptosis proteins by deguelin selectively induces apoptosis in breast cancer cells. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17046715&form=6&db=m Poly(ADP-ribose)polymerase inhibition decreases angiogenesis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17062697&form=6&db=m Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17088286&form=6&db=m PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17096162&form=6&db=m Apoptosis induced by ID6105, a new anthracycline (11-hydroxyaclacinomycin X, Hyrubicin), and its anti-tumor effects on experimental tumor models. diagnostic usage,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17214747&form=6&db=m Evidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17214964&form=6&db=m PARP1 Val762Ala polymorphism reduces enzymatic activity. diagnostic usage,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17234160&form=6&db=m Differences in the cellular response and signaling pathways of cisplatin and BBR3464 ([[trans-PtCl(NH3)(2)]2mu-(trans-Pt(NH3)(2)(H2N(CH2)(6)-NH2)2)]4+) influenced by copper homeostasis. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17258405&form=6&db=m Poly(ADP-ribose) polymerase (PARP) and DNA-fragmentation factor (DFF45): expression and correlation in normal, hyperplastic and neoplastic endometrial tissues. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17284532&form=6&db=m Adoptive transfer of tumor-primed, in vitro-activated, CD4+ T effector cells (TEs) combined with CD8+ TEs provides intratumoral TE proliferation and synergistic antitumor response. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17318223&form=6&db=m Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17332279&form=6&db=m Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17341890&form=6&db=m Frequent occurrence of abnormal E-cadherin/beta-catenin protein expression in advanced gallbladder cancers and its association with decreased apoptosis. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17413981&form=6&db=m Poly(adenosine diphosphate-ribose) polymerase expression in serous ovarian carcinoma: correlation with p53, MIB-1, and outcome. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17473206&form=6&db=m ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17474866&form=6&db=m Dietary fish oil deactivates a growth-promoting signaling pathway in hepatoma 7288CTC in Buffalo rats. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17504138&form=6&db=m Modulation of transcription by PARP-1: consequences in carcinogenesis and inflammation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17504797&form=6&db=m Nicotinamide abrogates acute lung injury caused by ischaemia/reperfusion. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17505006&form=6&db=m Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17520094&form=6&db=m Poly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17520700&form=6&db=m Effect of hyperthermia and chemotherapeutic agents on TRAIL-induced cell death in human colon cancer cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17560163&form=6&db=m Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17575213&form=6&db=m Restoration of tissue factor pathway inhibitor-2 in a human glioblastoma cell line triggers caspase-mediated pathway and apoptosis. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17606599&form=6&db=m Coxiella burnetii inhibits apoptosis in human THP-1 cells and monkey primary alveolar macrophages. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17614107&form=6&db=m Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17616810&form=6&db=m The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17617028&form=6&db=m Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17624601&form=6&db=m Hereditary breast cancer: pathobiology, clinical translation, and potential for targeted cancer therapeutics. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17628743&form=6&db=m INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase, enhances tumor response to doxorubicin. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640390&form=6&db=m A general framework for quantifying the effects of DNA repair inhibitors on radiation sensitivity as a function of dose. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17645773&form=6&db=m PolyADP-ribosylation and cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17663173&form=6&db=m [Role of proteins in Fas-mediated apoptosis in tumor cells and lymphocytes co-cultured in vitro] ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17689746&form=6&db=m Acute myocardial infarction induced increases in plasma tumor necrosis factor-alpha and interleukin-10 are associated with the activation of poly(ADP-ribose) polymerase of circulating mononuclear cell. causal interaction,diagnostic usage,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17714938&form=6&db=m Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786977&form=6&db=m Direct current electrical fields induce apoptosis in oral mucosa cancer cells by NADPH oxidase-derived reactive oxygen species. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17848598&form=6&db=m Aspirin enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in hormone-refractory prostate cancer cells through survivin down-regulation. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17890271&form=6&db=m Poly(ADP-ribose) polymerase inhibition reduces tumor necrosis factor-induced inflammatory response in rheumatoid synovial fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17896912&form=6&db=m PARP inhibitor development for systemic cancer targeting. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17919258&form=6&db=m Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17928930&form=6&db=m Oleanolic Acid Induces Apoptosis in Human Leukemia Cells through Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17943227&form=6&db=m Genetic sequence variations and ADPRT haplotype analysis in French Canadian families with high risk of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17954271&form=6&db=m Transcriptional profiling of genes at the human common fragile site FRA1H in tumor-derived cell lines. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17955442&form=6&db=m Delayed role of tumor necrosis factor- alpha in overcoming the effects of pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17975135&form=6&db=m Targeting Poly(ADP-Ribose) Polymerase: A Two-Armed Strategy for Cancer Therapy. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18006925&form=6&db=m DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18025084&form=6&db=m PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18058575&form=6&db=m Clinical poly(ADP-ribose) polymerase inhibitors for the treatment of cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18059167&form=6&db=m Inhibition of Stat3 Activity by YC-1 Enhances Chemo-Sensitivity in Hepatocellular Carcinoma. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18060030&form=6&db=m CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18073140&form=6&db=m Identification of poly(ADP-ribose) polymerase-1 as the OXPHOS-generated ATP sensor of nuclei of animal cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18078960&form=6&db=m Treatment with insulin inhibits poly(ADP-ribose)polymerase activation in a rat model of endotoxemia. causal interaction,diagnostic usage,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18164959&form=6&db=m Resveratrol-induced apoptosis in human breast cancer cells is mediated primarily through the caspase-3-dependent pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18189352&form=6&db=m Cytotoxic and antioxidant activity of 4-methylthio-3-butenyl isothiocyanate from Raphanus sativus L. (Kaiware Daikon) sprouts. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18221025&form=6&db=m Poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors in cancer chemotherapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18245064&form=6&db=m Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18263853&form=6&db=m Apoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress response. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18305405&form=6&db=m Low energy proton beam induces tumor cell apoptosis through reactive oxygen species and activation of caspases. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18314489&form=6&db=m Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18331465&form=6&db=m Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-kappaB and MAPK signalling. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18338172&form=6&db=m Antitumor activity of noscapine in human non-small cell lung cancer xenograft model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18343102&form=6&db=m DNA repair deficiency as a therapeutic target in cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18345031&form=6&db=m NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18353725&form=6&db=m Toward specific functions of poly(ADP-ribose) polymerase-2. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18356818&form=6&db=m Heat shock protein inhibitors increase the efficacy of measles virotherapy. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18369822&form=6&db=m Evaluation of tankyrase inhibition in whole cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18388863&form=6&db=m A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18410506&form=6&db=m Poly (ADP-ribose) polymerases (PARPs) 1-3 regulate astrocyte activation. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18440222&form=6&db=m Stable depletion of poly (ADP-ribose) polymerase-1 reduces in vivo melanoma growth and increases chemosensitivity. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18452087&form=6&db=m An Epstein-Barr virus positive natural killer lymphoma xenograft derived for drug testing. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18456354&form=6&db=m A novel poly(ADP-ribose) polymerase inhibitor, ABT-888, radiosensitizes malignant human cell lines under hypoxia. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18473725&form=6&db=m Targeting poly (ADP) ribose polymerase I (PARP-1) and PARP-1 interacting proteins for cancer treatment. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18508926&form=6&db=m DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18541433&form=6&db=m Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18542054&form=6&db=m Histone H2AX is a critical factor for cellular protection against DNA alkylating agents. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18547621&form=6&db=m Xenografts of primary human gynecological tumors grown under the renal capsule of NOD/SCID mice show genetic stability during serial transplantation and respond to cytotoxic chemotherapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18558578&form=6&db=m Poly(ADP-ribose)polymerase-1 (PARP-1) in carcinogenesis: potential role of PARP inhibitors in cancer treatment. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18559613&form=6&db=m Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18563705&form=6&db=m Regulatory changes of apoptotic factors in the bovine corpus luteum after induced luteolysis. diagnostic usage,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18575892&form=6&db=m Hereditary breast cancer: new genetic developments, new therapeutic avenues. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18586490&form=6&db=m Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18587655&form=6&db=m Role of PARP-1 and PARP-2 in the expression of apoptosis-regulating genes in HeLa cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18612434&form=6&db=m Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18619441&form=6&db=m Dependence of trans-ADP-ribosylation and nuclear glycolysis on the Arg 34-ATP complex of Zn2+ finger I of poly-ADP-ribose polymerase-1. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18644251&form=6&db=m Targeted therapy for cancer using PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18660545&form=6&db=m PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18665601&form=6&db=m Kaiware Daikon (Raphanus sativus L.) extract: a naturally multipotent chemopreventive agent. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18674509&form=6&db=m An enzyme-linked immunosorbent poly(ADP-ribose) polymerase biomarker assay for clinical trials of PARP inhibitors. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18695907&form=6&db=m PJ34, an inhibitor of PARP-1, suppresses cell growth and enhances the suppressive effects of cisplatin in liver cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18701487&form=6&db=m A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through antiproliferation and proapoptosis. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18716896&form=6&db=m PARP-1 Val762Ala polymorphism, CagA(+) H. pylori infection and risk for gastric cancer in Han Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18720553&form=6&db=m Secondary BRCA1 and BRCA2 alterations and acquired chemoresistance. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18720555&form=6&db=m PARP inhibitor tilts cell death from necrosis to apoptosis in cancer cells. ongoing research,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18728395&form=6&db=m Mouse models for BRCA1 associated tumorigenesis: from fundamental insights to preclinical utility. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18800822&form=6&db=m 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18806828&form=6&db=m Therapeutic targeting of Id2 reduces growth of human colorectal carcinoma in the murine liver. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18819994&form=6&db=m PARP inhibitors and cancer therapy - early results and potential applications. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18820000&form=6&db=m Exploiting the Achilles heel of cancer: the therapeutic potential of poly(ADP-ribose) polymerase inhibitors in BRCA2-defective cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18832051&form=6&db=m A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18835851&form=6&db=m Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18837894&form=6&db=m The potential of PARP inhibitors in genetic breast and ovarian cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18854964&form=6&db=m [Hereditary breast cancer] causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18945670&form=6&db=m Loss of androgen receptor in aging and oxidative stress through Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly(ADP-ribose) polymerase PARP-1. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18971340&form=6&db=m High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18977144&form=6&db=m Poly(ADP-ribose) polymerase-1 activity facilitates the dissociation of nuclear proteins from platinum-modified DNA. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18980982&form=6&db=m Preclinical modeling of a phase 0 clinical trial: qualification of a pharmacodynamic assay of poly (ADP-ribose) polymerase in tumor biopsies of mouse xenografts. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18986507&form=6&db=m Functional genomic analysis of drug sensitivity pathways to guide adjuvant strategies in breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19047122&form=6&db=m Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19053880&form=6&db=m Development of PARP inhibitors in oncology. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19060597&form=6&db=m Therapeutic strategies for triple-negative breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19090924&form=6&db=m QSAR study of 2-(1-Propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide as PARP inhibitors for treatment of cancer. diagnostic usage,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19109787&form=6&db=m Polymorphisms of DNA repair genes: ADPRT, XRCC1, and XPD and cancer risk in genetic epidemiology. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19132288&form=6&db=m Achyranthoside H methyl ester, a novel oleanolic acid saponin derivative from Achyranthes fauriei roots, induces apoptosis in human breast cancer MCF-7 and MDA-MB-453 cells via a caspase activation pathway. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19135124&form=6&db=m Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19138990&form=6&db=m Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19139007&form=6&db=m Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19143569&form=6&db=m Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19147766&form=6&db=m In vitro and in vivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19174487&form=6&db=m Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19208614&form=6&db=m The potential role and application of PARP inhibitors in cancer treatment. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19240165&form=6&db=m Coordination of DNA mismatch repair and base excision repair processing of chemotherapy and radiation damage for targeting resistant cancers. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19247492&form=6&db=m APOMAB, a La-specific monoclonal antibody, detects the apoptotic tumor response to life-prolonging and DNA-damaging chemotherapy. causal interaction,diagnostic usage,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19258025&form=6&db=m The early immunological response to acute ischemic stroke: Differential gene expression in subpopulations of mononuclear cells. diagnostic usage,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19266268&form=6&db=m Anti-androgen receptor signaling and prostate cancer inhibitory effects of sucrose- and benzophenone-compounds. diagnostic usage,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19336573&form=6&db=m High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19354255&form=6&db=m Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19362586&form=6&db=m PARP inhibitors: New partners in the therapy of cancer and inflammatory diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19364967&form=6&db=m Phase 0 Clinical Trial of the Poly (ADP-Ribose) Polymerase Inhibitor ABT-888 in Patients With Advanced Malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19383921&form=6&db=m Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19408576&form=6&db=m Effects of cardiotoxin III on NF-kappaB function, proliferation, and apoptosis in human breast MCF-7 cancer cells. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19426673&form=6&db=m PARP-1 inhibition-induced activation of PI-3-kinase-Akt pathway promotes resistance to taxol. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19428377&form=6&db=m Role of Parp-1 in suppressing spontaneous deletion mutation in the liver and brain of mice at adolescence and advanced age. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19447888&form=6&db=m Positive transcriptional regulation of the human micro opioid receptor gene by poly(ADP-ribose) polymerase-1 and increase of its DNA binding affinity based on polymorphism of G-172 -> T. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19486340&form=6&db=m Fragile gene product, Fhit, in oxidative and replicative stress responses. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19526240&form=6&db=m Plasma and cerebrospinal fluid pharmacokinetics of ABT-888 after oral administration in non-human primates. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19531648&form=6&db=m 3,3'-Diindolylmethane enhances chemosensitivity of multiple chemotherapeutic agents in pancreatic cancer. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19533660&form=6&db=m PARP1 expression in pediatric central nervous system tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19553107&form=6&db=m Identification of aminoethyl pyrrolo dihydroisoquinolinones as novel poly(ADP-ribose) polymerase-1 inhibitors. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19553641&form=6&db=m Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19568233&form=6&db=m Poly(ADP-ribose) polymerase-1 polymorphisms, expression and activity in selected human tumour cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19584263&form=6&db=m Elevated poly-(ADP-ribose)-polymerase activity sensitizes retinoblastoma-deficient cells to DNA damage-induced necrosis. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19584311&form=6&db=m Ethyl pyruvate administration inhibits hepatic tumor growth. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19604089&form=6&db=m Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19621390&form=6&db=m The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19648052&form=6&db=m Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19652380&form=6&db=m Asiatic acid induces colon cancer cell growth inhibition and apoptosis through mitochondrial death cascade. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19661320&form=6&db=m mTOR, S6 and AKT expression in relation to proliferation and apoptosis/autophagy in glioma. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19741614&form=6&db=m PARP inhibitors blaze a trail in difficult-to-treat cancers. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19743897&form=6&db=m Poly(ADP-ribose) polymerase inhibition in cancer therapy: are we close to maturity? causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19783937&form=6&db=m The vitamin nicotinamide: translating nutrition into clinical care. diagnostic usage,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19784808&form=6&db=m Doxorubicin-mediated apoptosis in glioma cells requires NFAT3. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19804613&form=6&db=m Development of 'synthetic lethal' strategies to target BRCA1-deficient breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19808869&form=6&db=m Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19823047&form=6&db=m Immunohistochemical detection of poly(ADP-ribose) polymerase inhibition by ABT-888 in patients with refractory solid tumors and lymphomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19825992&form=6&db=m Acquired Resistance to Combination Treatment with Temozolomide and ABT-888 Is Mediated by Both Base Excision Repair and Homologous Recombination DNA Repair Pathways. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19836377&form=6&db=m Impaired DNA damage response - An Achilles' heel sensitizing cancer to chemotherapy and radiotherapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19855437&form=6&db=m Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19873981&form=6&db=m Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19888760&form=6&db=m Synthesis and evaluation of a new generation of orally efficacious benzimidazole-based poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors as anticancer agents. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19890834&form=6&db=m Inhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19904742&form=6&db=m SYUNZ-16, a newly synthesized alkannin derivative, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of AKT/FOXO signal pathway. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19926276&form=6&db=m Poly(ADP-ribose) polymerase inhibitors in cancer treatment: a clinical perspective. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19934293&form=6&db=m ABT-888 confers broad in vivo activity in combination with temozolomide in diverse tumors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19934756&form=6&db=m The emerging potential of poly(ADP-ribose) polymerase inhibitors in the treatment of breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19939726&form=6&db=m PARP inhibitors in cancer therapy: two modes of attack on the cancer cell widening the clinical applications. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19961617&form=6&db=m Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20007017&form=6&db=m Synthesis and biological evaluation of substituted 2-phenyl-2H-indazole-7-carboxamides as potent poly(ADP-ribose) polymerase (PARP) inhibitors. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20017885&form=6&db=m PARP inhibitors and the treatment of breast cancer: beyond BRCA1/2? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20022747&form=6&db=m Development of substituted 6-[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2H)-ones as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors active in BRCA deficient cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20027033&form=6&db=m High poly(adenosine diphosphate-ribose) polymerase expression and poor survival in advanced-stage serous ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20031401&form=6&db=m Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1). causal interaction,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20034026&form=6&db=m Inhibition of poly adenosine diphosphate-ribose polymerase decreases hepatocellular carcinoma growth by modulation of tumor-related gene expression. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20036271&form=6&db=m Arsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20045315&form=6&db=m Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20049345&form=6&db=m The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20049732&form=6&db=m Converting cancer mutations into therapeutic opportunities. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20049735&form=6&db=m Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20060649&form=6&db=m Triple-negative breast cancer: molecular features, pathogenesis, treatment and current lines of research. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20067769&form=6&db=m Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20072652&form=6&db=m A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20092359&form=6&db=m Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20096707&form=6&db=m Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20103608&form=6&db=m Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20113831&form=6&db=m Analysis of poly(ADP-ribose) polymerase-1 (PARP1) gene alteration in human germ cell tumor cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20124459&form=6&db=m ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20127978&form=6&db=m Genetic diagnosis of familial breast cancer using clonal sequencing. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20133863&form=6&db=m Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20140280&form=6&db=m BRCA in breast cancer: from risk assessment to therapeutic prediction. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20145538&form=6&db=m Tranilast inhibits cell proliferation and migration and promotes apoptosis in murine breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20156552&form=6&db=m Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: differential cytotoxicity in healthy and cancer cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20164690&form=6&db=m Poly(ADP-ribose) polymerase inhibitors in triple-negative breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20182810&form=6&db=m Inhibition of Poly(ADP-Ribose) Polymerase Enhances the Effect of Chemotherapy in an Animal Model of Regional Therapy for the Treatment of Advanced Extremity Malignant Melanoma. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20197250&form=6&db=m [Identification of basal-like carcinomas in clinical practice: "triple zero/BRCA1-like" carcinomas] causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20209601&form=6&db=m Down-regulation of tyrosine aminotransferase at a frequently deleted region 16q22 contributes to the pathogenesis of hepatocellular carcinoma. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20214890&form=6&db=m A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20227390&form=6&db=m Rosiglitazone enhances the radiosensitivity of p53-mutant HT-29 human colorectal cancer cells. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20233726&form=6&db=m Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20331454&form=6&db=m Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20334625&form=6&db=m Systemic DNA damage response and metabolic syndrome as a premalignant state. causal interaction,diagnostic usage,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20351092&form=6&db=m Homologous recombination in cancer development, treatment and development of drug resistance. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20357221&form=6&db=m New Therapeutic and Biomarker Discovery for Peripheral Diabetic Neuropathy: PARP Inhibitor, Nitrotyrosine, and Tumor Necrosis Factor-{alpha} causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20359158&form=6&db=m [Molecular basis of breast cancer related to BRCA 1 and BRCA2 genes: characteristics and targeting therapy] causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20370684&form=6&db=m Pharmacological Inhibition of Poly(ADP-ribose) Polymerase (PARP) Activity in PARP-1 Silenced Tumour Cells Increases Chemosensitivity to Temozolomide and to a N3-Adenine Selective Methylating Agent. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20371688&form=6&db=m Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20371716&form=6&db=m Antitumor efficacy profile of PKI-402, a dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20373286&form=6&db=m Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20373860&form=6&db=m PARP inhibitors in BRCA1-/BRCA2-associated and triple-negative breast cancers. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20383759&form=6&db=m PARP and PARG Inhibitors-New Therapeutic Targets in Cancer Treatment. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20385443&form=6&db=m Targeting DNA repair in breast cancer: A clinical and translational update. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20392997&form=6&db=m Synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival Akt, mTOR and NF-{kappa}B signaling proteins in colorectal cancer cells. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20406170&form=6&db=m Inducing Synthetic Lethality using PARP Inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20409643&form=6&db=m Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20417190&form=6&db=m PARP inhibitors: New tools to protect from inflammation. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20419844&form=6&db=m LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20459571&form=6&db=m High level of apoptosis and low AKT activation in mass screening as opposed to standard neuroblastoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20464779&form=6&db=m Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20485165&form=6&db=m PARP inhibition: targeting the Achilles' heel of DNA repair to treat germline and sporadic ovarian cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20525240&form=6&db=m Enhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20530711&form=6&db=m Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20547104&form=6&db=m Combinations of PARP, hedgehog and HDAC inhibitors with standard drugs. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20551068&form=6&db=m Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20568893&form=6&db=m PARP-1 inhibitors: a novel genetically specific agents for cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20582464&form=6&db=m DNA repair signature is associated with anthracycline response in triple negative breast cancer patients. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20609467&form=6&db=m Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20610628&form=6&db=m Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20631063&form=6&db=m 6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20633624&form=6&db=m Cytotoxicity and bioavailability studies on a decoction of Oldenlandia diffusa and its fractions separated by HPLC. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20643208&form=6&db=m Multifarious molecular signaling cascades of cardiac hypertrophy: can the muddy waters be cleared? causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20643861&form=6&db=m A review of PARP inhibitors: from bench to bedside. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20645701&form=6&db=m Poly(ADP-ribosyl)ation polymerases: mechanism and new target of anticancer therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20647696&form=6&db=m [Breakthrough breast cancer treatment--PARP inhibitor, BRCA, and triple negative breast cancer] diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20660013&form=6&db=m PARP1 suppresses homologous recombination events in mice in vivo. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20662543&form=6&db=m Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives. Part 2. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20674553&form=6&db=m Inhibition of cell growth and potentiation of tumor necrosis factor-? (TNF-?)-induced apoptosis by a phenanthroindolizidine alkaloid antofine in human colon cancer cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20676117&form=6&db=m Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20678253&form=6&db=m Inhibition of poly (ADP-Ribose) polymerase-1 in telomerase deficient mouse embryonic fibroblasts increases arsenite-induced genome instability. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20696794&form=6&db=m Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20725615&form=6&db=m Role of nicotinamide in DNA damage, mutagenesis, and DNA repair. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20725763&form=6&db=m Targeting poly(ADP-ribose) polymerase activity for cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20739657&form=6&db=m The PARP inhibitor olaparib induces significant killing of ATM deficient lymphoid tumour cells in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20798217&form=6&db=m Synergistic chemosensitivity of triple-negative breast cancer cell lines to poly(ADP-Ribose) polymerase inhibition, gemcitabine, and cisplatin. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20799148&form=6&db=m Iniparib, a PARP1 inhibitor for the potential treatment of cancer, including triple-negative breast cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20802015&form=6&db=m A marker of homologous recombination predicts pathological complete response to neoadjuvant chemotherapy in primary breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20802516&form=6&db=m PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20823142&form=6&db=m Poly (adp-ribose) polymerase as a novel therapeutic target in cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20823146&form=6&db=m Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20832020&form=6&db=m Poly(ADP-ribose) polymerase inhibition as a model for synthetic lethality in developing radiation oncology targets. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20842729&form=6&db=m BARD1 homozygous deletion, a possible alternative to BRCA1 mutation in basal breast cancer. diagnostic usage,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20853319&form=6&db=m How to kill tumor cells with inhibitors of poly(ADP-ribosyl)ation. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20857352&form=6&db=m Consumer Beware: A Systematic Assessment of Potential Bias in the Lay Electronic Media to Examine the Portrayal of "PARP" Inhibitors for Cancer Treatment. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20877296&form=6&db=m Triple-negative breast cancer: disease entity or title of convenience? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20879987&form=6&db=m Overcoming Resistance of Glioblastoma to Conventional Cytotoxic Therapies by the Addition of PARP Inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20924112&form=6&db=m Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20937646&form=6&db=m Indicators of homologous recombination deficiency in breast cancer and association with response to neoadjuvant chemotherapy. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20941507&form=6&db=m Immunophenotypic predictive profiling of BRCA1-associated breast cancer. causal interaction,diagnostic usage,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20944105&form=6&db=m Growth inhibitory and apoptosis-inducing effects of xanthohumol, a prenylated chalone present in hops, in human prostate cancer cells. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20948822&form=6&db=m PARP inhibitors in BRCA1/BRCA2 germline mutation carriers with ovarian and breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20955770&form=6&db=m Tumor necrosis factor-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 mediate cerebral ischemia-induced poly(ADP-ribose) polymerase-1 activation and neuronal death. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20973257&form=6&db=m Moving toward personalized medicine: treatment-focused genetic testing of women newly diagnosed with ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20976469&form=6&db=m Synthetic lethal interactions for the development of cancer therapeutics: biological and methodological advancements. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21034216&form=6&db=m Therapeutic Approaches for Women Predisposed to Breast Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21034966&form=6&db=m The ATM-Chk2 and ATR-Chk1 Pathways in DNA Damage Signaling and Cancer. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21037379&form=6&db=m Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21061222&form=6&db=m Tephrosin-induced autophagic cell death in A549 non-small cell lung cancer cells. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21069454&form=6&db=m Poly(ADP-ribose) polymerase-1 mRNA expression in human breast cancer: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21093979&form=6&db=m Inhibition of poly (ADP-ribose) polymerase-1 enhances doxorubicin activity against liver cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21097693&form=6&db=m Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21109939&form=6&db=m HARP?111-136 enhances radiation-induced apoptosis of U87MG glioblastoma by induction of the proapoptotic protein CHOP. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21109977&form=6&db=m mda-7/IL-24 induces apoptosis in human GBC-SD gallbladder carcinoma cells via mitochondrial apoptotic pathway. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21138954&form=6&db=m Molecular stratification of triple-negative breast cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21138955&form=6&db=m Directed therapy of subtypes of triple-negative breast cancer. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21145219&form=6&db=m Sialic acid surface decoration enhances cellular uptake and apoptosis-inducing activity of selenium nanoparticles. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21170677&form=6&db=m Oral administration of benzyl-isothiocyanate inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21183737&form=6&db=m Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21187397&form=6&db=m Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21195000&form=6&db=m miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21205087&form=6&db=m Secondary mutations of BRCA1/2 and drug resistance. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21205831&form=6&db=m Poly(ADP-ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21214291&form=6&db=m High energy shock waves and 5-aminolevulinic for sonodynamic therapy: effects in a syngeneic model of colon cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21224467&form=6&db=m Notch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21253797&form=6&db=m Chemoprevention of hormone receptor-negative breast cancer: new approaches needed. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21266191&form=6&db=m Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells. ongoing research,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21270334&form=6&db=m Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21276153&form=6&db=m No associations of polymorphisms in ADPRT with hepatitis B virus clearance and hepatocellular carcinoma occurrence in a Korean population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21278442&form=6&db=m Molecular stratification of triple-negative breast cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21278443&form=6&db=m Directed therapy of subtypes of triple-negative breast cancer. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21285153&form=6&db=m The clinical development of inhibitors of poly(ADP-ribose) polymerase. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21293287&form=6&db=m Expression of poly (adenosine diphosphate-ribose) polymerase and p53 in epithelial ovarian cancer and their role in prognosis and disease outcome. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21316599&form=6&db=m PARP inhibitors in cancer therapy: promise, progress, and puzzles. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21325073&form=6&db=m Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21326243&form=6&db=m A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21331759&form=6&db=m Studying Therapy Response and Resistance in Mouse Models for BRCA1-Deficient Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21343230&form=6&db=m PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21348828&form=6&db=m Drugs interfering with apoptosis in breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21360002&form=6&db=m Clinical management of hereditary breast cancer syndromes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21368455&form=6&db=m [PARP inhibitors for cancer therapy]. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21385925&form=6&db=m Transcription-induced DNA double strand breaks: both an oncogenic force and potential therapeutic target? causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21399878&form=6&db=m The poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide suppresses cell growth and migration, enhancing suppressive effects of cisplatin in osteosarcoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21409392&form=6&db=m PARP-1 expression in breast cancer including BRCA1-associated, triple negative and basal-like tumors: possible implications for PARP-1 inhibitor therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21424107&form=6&db=m Poly (ADP-ribose) polymerase-1 Inhibition: Preclinical and Clinical Development of Synthetic Lethality. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21434873&form=6&db=m Poly(ADP-ribose) polymerase-1 (PARP-1) pharmacogenetics, activity and expression analysis in cancer patients and healthy volunteers. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21436403&form=6&db=m DISPOSITION AND DRUG-DRUG INTERACTION POTENTIAL OF VELIPARIB (ABT-888), A NOVEL AND POTENT INHIBITOR OF POLY(ADP-RIBOSE) POLYMERASE. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21441464&form=6&db=m Synthetic lethality: exploiting the addiction of cancer to DNA repair. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21447800&form=6&db=m c-MYC Suppresses BIN1 to Release Poly(ADP-Ribose) Polymerase 1: A Mechanism by Which Cancer Cells Acquire Cisplatin Resistance. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21459330&form=6&db=m PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21459711&form=6&db=m Voies de réparation de l'ADN et cancers bronchiques non à petites cellules : perspectives cliniques. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21459712&form=6&db=m Inhibiteurs de la PARP : des avancées significatives dans le traitement des cancers. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21462088&form=6&db=m Garcinol Inhibits Cell Proliferation and Promotes Apoptosis in Pancreatic Adenocarcinoma Cells. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21467790&form=6&db=m Protective Effects of Cilostazol against Transient Focal Cerebral Ischemia and Hemorrhagic Transformation. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21468130&form=6&db=m Treatment with olaparib in a patient with PTEN-deficient endometrioid endometrial cancer. diagnostic usage,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21468218&form=6&db=m Helicobacter pylori activation of PARP-1: Usurping a versatile regulator of host cellular health. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21469749&form=6&db=m The key residues of active sites on the catalytic fragment for Paclitaxel interacting with poly (adp-ribose) polymerase. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21470549&form=6&db=m The therapeutic ratio is preserved for radiotherapy or cisplatin treatment in BRCA2-mutated prostate cancers. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21485757&form=6&db=m PARP inhibitors in oncology: a new synthetic lethal approach to cancer therapy. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21487248&form=6&db=m Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21537476&form=6&db=m Targeted therapies in epithelial ovarian cancer: Molecular mechanisms of action. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21555554&form=6&db=m Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21571912&form=6&db=m Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21577210&form=6&db=m Poly(ADP-ribose)-dependent regulation of Snail1 protein stability. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21585709&form=6&db=m Molecular Modeling Studies on Benzimidazole Carboxamide Derivatives as PARP-1 Inhibitors Using 3D-QSAR and Docking. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21590367&form=6&db=m Safety and tolerability of the poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib (AZD2281) in combination with topotecan for the treatment of patients with advanced solid tumors: a phase I study. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21594428&form=6&db=m Identification of a rearrangement in the 5' upstream region of the poly(ADP-ribose) polymerase pseudogene on chromosome 13 in Ewing's sarcoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21598039&form=6&db=m Shogaols at proapoptotic concentrations induce G(2)/M arrest and aberrant mitotic cell death associated with tubulin aggregation. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21607289&form=6&db=m Cordycepin blocks lung injury-associated inflammation and promotes BRCA1-deficient breast cancer cell killing by effectively inhibiting PARP. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21612407&form=6&db=m Lymph Node Metastasis of Gastric Cancer Is Associated with the Interaction Between Poly (ADP-Ribose) Polymerase 1 and Matrix Metallopeptidase 2. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21613406&form=6&db=m Poly(ADP-Ribose) Polymerase Inhibition Synergizes with 5-Fluorodeoxyuridine but not 5-Fluorouracil in Ovarian Cancer Cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21618343&form=6&db=m Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21641992&form=6&db=m Selective targeting of breast cancer cells through ROS-mediated mechanisms potentiates the lethality of paclitaxel by a novel diterpene, gelomulide K. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21667019&form=6&db=m Anticancer mechanism of equol in 7,12-dimethylbenz(a)anthracene-treated animals. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21677381&form=6&db=m Strategies for H-score normalization of preanalytical technical variables with potential utility to immunohistochemical-based biomarker quantitation in therapeutic reponse diagnostics. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21692479&form=6&db=m Discovery and Structure-Activity Relationships of Modified Salicylanilides as Cell Permeable Inhibitors of Poly(ADP-ribose) Glycohydrolase (PARG). causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21695716&form=6&db=m ShRNA-mediated silencing of Gli2 gene inhibits proliferation and sensitizes human hepatocellular carcinoma cells towards TRAIL-induced apoptosis. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21706030&form=6&db=m Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21706052&form=6&db=m NF-?B mediates radio-sensitization by the PARP-1 inhibitor, AG-014699. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21706479&form=6&db=m PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21707865&form=6&db=m Response of subtype-specific human breast cancer-derived cells to poly(ADP-ribose) polymerase and checkpoint kinase 1 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21715099&form=6&db=m Defective homologous recombination in human cancers. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21718592&form=6&db=m PARP inhibitors: its role in treatment of cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21719137&form=6&db=m The poly(ADP-Ribose) polymerase inhibitor ABT-888 reduces radiation-induced nuclear EGFR and augments head and neck tumor response to radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21763418&form=6&db=m Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21775006&form=6&db=m Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21777194&form=6&db=m The Emerging Role of Poly(ADP-Ribose) Polymerase Inhibitors in Cancer Treatment. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21778572&form=6&db=m Current Treatment Options in Triple Negative Breast Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21779467&form=6&db=m Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21795476&form=6&db=m Phase I Study of PARP Inhibitor ABT-888 in Combination with Topotecan in Adults with Refractory Solid Tumors and Lymphomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21800052&form=6&db=m Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21820932&form=6&db=m [The future of breast cancer radiotherapy: From one size fits all to taylor-made treatment.] causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21821012&form=6&db=m PARP1 inhibitors attenuate AKT phosphorylation via the upregulation of PHLPP1. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21821475&form=6&db=m The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21822267&form=6&db=m Germline mutations in RAD51D confer susceptibility to ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21825006&form=6&db=m Inhibition of poly(ADP-ribose) polymerase-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21849329&form=6&db=m Pediatric high-grade glioma: identification of poly(ADP-ribose) polymerase as a potential therapeutic target. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21862406&form=6&db=m PARP inhibitors in cancer: moving beyond BRCA. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21870265&form=6&db=m The Use of PARP Inhibitors in Cancer Therapy: Use as Adjuvant with Chemotherapy or Radiotherapy; Use as a Single Agent in Susceptible Patients; Techniques Used to Identify Susceptible Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21870266&form=6&db=m Quantification of PARP Activity in Human Tissues: Ex Vivo Assays in Blood Cells and Immunohistochemistry in Human Biopsies. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21870276&form=6&db=m Genetic Dissection of PARylation in the Filamentous Fungus Neurospora crassa. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21878655&form=6&db=m Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21884432&form=6&db=m The role of poly adenosine diphosphate ribose polymerase inhibitors in breast and ovarian cancer: current status and future directions. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21884642&form=6&db=m Poly(ADP-ribose) polymerase inhibition: a new direction for BRCA and triple-negative breast cancer? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21884784&form=6&db=m Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21908496&form=6&db=m Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21912620&form=6&db=m Cetuximab augments cytotoxicity with poly (adp-ribose) polymerase inhibition in head and neck cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21913063&form=6&db=m PARP inhibitors in BRCA gene-mutated ovarian cancer and beyond. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21916578&form=6&db=m Therapeutic potential of PARP inhibitors for metastatic breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21917650&form=6&db=m Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival of gastric cancer. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21922196&form=6&db=m Genomic instability in breast and ovarian cancers: translation into clinical predictive biomarkers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21926192&form=6&db=m The clinically active PARP inhibitor AG014699 ameliorates cardiotoxicity but does not enhance the efficacy of doxorubicin, despite improving tumor perfusion and radiation response in mice. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21934105&form=6&db=m An emerging entity: pancreatic adenocarcinoma associated with a known BRCA mutation: clinical descriptors, treatment implications, and future directions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21935571&form=6&db=m Apoptotic and anti-angiogenic effects of Pulsatilla koreana extract on hepatocellular carcinoma. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21936500&form=6&db=m Inhibitory effects of resveratrol and pterostilbene on human colon cancer cells: a side-by-side comparison. diagnostic usage,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21943092&form=6&db=m A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21947268&form=6&db=m Adjuvant immunotherapy of C6 glioma in rats with pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21968427&form=6&db=m The ups and downs of DNA repair biomarkers for PARP inhibitor therapies. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21968702&form=6&db=m PARP-1 and PARP-2: New players in tumour development. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21988227&form=6&db=m Synergistic tumor suppression by adenovirus-mediated inhibitor of growth 4 and interleukin-24 gene cotransfer in hepatocarcinoma cells. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21989215&form=6&db=m The role of PARP in DNA repair and its therapeutic exploitation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21993423&form=6&db=m Effect of curcumin on irradiated and estrogen-transformed human breast cell lines. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22011283&form=6&db=m Inhibition of poly(ADP-ribose) polymerase (PARP) induces apoptosis in lung cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22015278&form=6&db=m PARP inhibitors--current status and the walk towards early breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22028822&form=6&db=m Modeling pharmacodynamic response to the poly(ADP-Ribose) polymerase inhibitor ABT-888 in human peripheral blood mononuclear cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22043043&form=6&db=m Biomarkers predicting clinical benefit: fact or fiction? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22043054&form=6&db=m The triple-negative subtype: new ideas for the poorest prognosis breast cancer. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22055391&form=6&db=m A snapshot of chemoresistance to PARP inhibitors. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22072524&form=6&db=m Photodynamic Therapy of Pheophorbide a Inhibits the Proliferation of Human Breast Tumour via Both Caspase-dependent and -independent Apoptotic Pathways in In Vitro and In Vivo Models. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22078487&form=6&db=m Targeting poly(ADP-ribose) polymerase-1 as a promising approach for immunomodulation in multiple sclerosis? causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22084640&form=6&db=m The potential for poly (ADP-ribose) polymerase inhibitors in cancer therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22101337&form=6&db=m Poly(ADP-ribose) polymerase inhibition enhances p53-dependent and -independent DNA damage responses induced by DNA damaging agent. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22106552&form=6&db=m PARP inhibitors in breast cancer: BRCA and beyond. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22111536&form=6&db=m Strategies towards more effective anticancer therapies: targeting DNA damage response pathways. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22114138&form=6&db=m PTEN Deletion in Prostate Cancer Cells Does Not Associate with Loss of RAD51 Function: Implications for Radiotherapy and Chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22116506&form=6&db=m Somatic mutations in the BRCA1 gene in Chinese women with sporadic breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22122466&form=6&db=m Base excision repair, the redox environment and therapeutic implications. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22127459&form=6&db=m MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiation. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22127734&form=6&db=m Association between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22128301&form=6&db=m Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a Bona Fide PARP inhibitor. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22145984&form=6&db=m A Phase I, dose-finding and pharmacokinetic study of olaparib (AZD2281) in Japanese patients with advanced solid tumors*,†. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22148838&form=6&db=m Bivalent smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents. diagnostic usage,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22158356&form=6&db=m Re-evaluating PARP1 inhibitor in cancer. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22158865&form=6&db=m Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22172724&form=6&db=m BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22179830&form=6&db=m Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22180407&form=6&db=m Update on PARP1 inhibitors in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22184287&form=6&db=m PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22220926&form=6&db=m Selective Small Molecule Inhibition of Poly(ADP-Ribose) Glycohydrolase (PARG). causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22223088&form=6&db=m Phase I study to assess the safety and tolerability of olaparib in combination with bevacizumab in patients with advanced solid tumours. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22223166&form=6&db=m Synergistic inhibition of hepatocellular carcinoma growth by cotargeting chromatin modifying enzymes and poly (ADP-ribose) polymerases. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22262190&form=6&db=m Chemotherapy-induced p53-dependent and -independent DNA damage responses are enhanced by poly(ADP-ribose) polymerase (PARP) inhibition in BRCA-proficient cancer cells. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22263793&form=6&db=m Triple-negative breast cancer and Poly(ADP-ribose) polymerase inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22268386&form=6&db=m Targeted Therapy for Brain Tumours: Role of PARP Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22272282&form=6&db=m Identification and analysis of the active phytochemicals from the anti-cancer botanical extract Bezielle. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22287547&form=6&db=m PARP-1 inhibition as a targeted strategy to treat Ewing's sarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22289927&form=6&db=m Cytotoxic gold compounds: synthesis, biological characterization and investigation of their inhibition properties of the zinc finger protein PARP-1. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22291137&form=6&db=m Failure of Iniparib to Inhibit Poly(ADP-Ribose) Polymerase In Vitro. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22293948&form=6&db=m Effects on apoptosis and cell cycle arrest contribute to the antitumor responses of interleukin-27 mediated by retrovirus in human pancreatic carcinoma cells. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22307137&form=6&db=m A Phase I Study of Veliparib in Combination with Metronomic Cyclophosphamide in Adults with Refractory Solid Tumors and Lymphomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22307387&form=6&db=m Three apoptotic genes are upregulated in a patient with Alzheimer's disease and well-differentiated squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22319564&form=6&db=m Bezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and OXPHOS. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22321899&form=6&db=m PARP-1 inhibition induces a late increase in the level of reactive oxygen species in cells after ionizing radiation. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22337872&form=6&db=m CHFR regulates the mitotic checkpoint by targeting PARP-1 for ubiquitination and degradation. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22363217&form=6&db=m Sarcophine-diol, a skin cancer chemopreventive agent, inhibits proliferation and stimulates apoptosis in mouse melanoma b(16)f(10) cell line. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22371451&form=6&db=m A Phase I Combination Study of Olaparib with Cisplatin and Gemcitabine in Adults with Solid Tumors. diagnostic usage,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22392482&form=6&db=m Synthetic lethality of PARP inhibition in BRCA-network disrupted tumor cells is associated with interferon pathway activation and enhanced by interferon-? causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22401667&form=6&db=m Advances in using PARP inhibitors to treat cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22402131&form=6&db=m A small molecule Focal Adhesion Kinase (FAK) inhibitor, targeting Y397 site: 1-(2-Hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [3.3.1.13,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo. causal interaction,ongoing research,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22404155&form=6&db=m Radiosensitization Effect of PARP Inhibition in Cells Exposed to Low and High LET Radiation. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22410125&form=6&db=m Silencing of HSulf-2 expression in MCF10DICS.com cells attenuate ductal carcinoma in situ progression to invasive ductal carcinoma in vivo. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22412391&form=6&db=m Synthetic Lethality of Cohesins with PARPs and Replication Fork Mediators. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22416035&form=6&db=m Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22429135&form=6&db=m Poly(ADP-ribosylation) and neoplastic transformation:Effect of PARP inhibitors. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22433057&form=6&db=m Combined Effect of Hsp90 Inhibitor Geldanamycin and Parthenolide via Reactive Oxygen Species-Mediated Apoptotic Process on Epithelial Ovarian Cancer Cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22443171&form=6&db=m Poly (ADP-ribose) polymerase (PARP): rationale, preclinical and clinical evidences of its inhibition as breast cancer treatment. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22443631&form=6&db=m Cucurbitacins as inducers of cell death and a rich source of potential anticancer compounds. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22447567&form=6&db=m Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22450359&form=6&db=m [PARP inhibitors and breast cancer: update and perspectives]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22464251&form=6&db=m Rare mutations in XRCC2 increase the risk of breast cancer. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22465181&form=6&db=m Guanylate cyclase activator YC-1 potentiates apoptotic effect of licochalcone A on human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathways. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22469522&form=6&db=m The diverse roles and clinical relevance of PARPs in DNA damage repair: current state of the art. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22472122&form=6&db=m Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-term tumor regression. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22472897&form=6&db=m PARP-1 protein expression in glioblastoma multiforme. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22476188&form=6&db=m Targeting the DNA damage response in oncology: past, present and future perspectives. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22489345&form=6&db=m PARP inhibition in epithelial ovarian cancer: high hopes undergo a reality check. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22493268&form=6&db=m Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22495455&form=6&db=m Poly (ADP-ribose) Polymerase Inhibitors in Cancer Treatment. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22504675&form=6&db=m [Clinical development of PARP inhibitors]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22508043&form=6&db=m Trolox enhances curcumin's cytotoxicity through induction of oxidative stress. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22520984&form=6&db=m Poly(Adenosine diphosphate-ribose) polymerase inhibitors in cancer treatment. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22530568&form=6&db=m Apoptosis signal-regulating kinase 1-thioredoxin complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22532167&form=6&db=m An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22574158&form=6&db=m Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22583868&form=6&db=m Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22586318&form=6&db=m Stumbling blocks on the path to personalized medicine in breast cancer: the case of PARP inhibitors for BRCA1/2-associated cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22596349&form=6&db=m Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in mammary tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22606268&form=6&db=m A novel sLRP6E1E2 inhibits canonical Wnt signaling, epithelial-to-mesenchymal transition, and induces mitochondria-dependent apoptosis in lung cancer. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22614020&form=6&db=m PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22624032&form=6&db=m PARP-1 Val762Ala polymorphism is associated with risk of cervical carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22641286&form=6&db=m Targeted molecular therapies for ovarian cancer: an update and future perspectives (Review). causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22655123&form=6&db=m PARP Inhibitors for the Treatment and Prevention of Breast Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22660976&form=6&db=m The role of PARP1 in the DNA damage response and its application in tumor therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22673632&form=6&db=m BRCAness: finding the Achilles heel in ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22706117&form=6&db=m [PARP inhibitors--theoretical basis and clinical application]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22706123&form=6&db=m [Poly(ADP-ribose) polymerase (PARP) inhibitors in BRCA1/2 cancer therapy]. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22754593&form=6&db=m Triple-negative breast cancer: are we making headway at least? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22766219&form=6&db=m Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22778154&form=6&db=m Enhancement of Synthetic Lethality via Combinations of ABT-888, a PARP Inhibitor, and Carboplatin In Vitro and In Vivo Using BRCA1 and BRCA2 Isogenic Models. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22788767&form=6&db=m Role of PARP Inhibitors in Cancer Biology and Therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22788971&form=6&db=m Olaparib , PARP1 inhibitor in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22791366&form=6&db=m Systemic therapy options in BRCA mutation-associated breast cancer. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22803332&form=6&db=m Protective effects of the ethanolic extract of Melia toosendan fruit against colon cancer. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22823444&form=6&db=m 17?-androstenediol-mediated oncophagy of tumor cells by different mechanisms is determined by the target tumor. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22830406&form=6&db=m PARP cleavage and perturbance in mitochondrial membrane potential by 3-?-propionyloxy-?-boswellic acid results in cancer cell death and tumor regression in murine models. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22834679&form=6&db=m PARP Inhibitors: Mechanism of Action and Their Potential Role in the Prevention and Treatment of Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22864776&form=6&db=m Colorectal cancers differ in respect of PARP-1 protein expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22865450&form=6&db=m RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22865487&form=6&db=m 18?-Glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22868923&form=6&db=m Epstein-Barr Virus Infection and Altered Control of Apoptotic Pathways in Posttransplant Lymphoproliferative Disorders. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22886647&form=6&db=m PARP Inhibitors Refocus for Rebound. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22906755&form=6&db=m PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22915039&form=6&db=m Altered Expression of the Poly(ADP-Ribosyl)ation Enzymes in Uveal Melanoma and Regulation of PARG Gene Expression by the Transcription Factor ERM. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22915752&form=6&db=m PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA proficient triple negative breast cancer to PARP inhibition. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22926640&form=6&db=m Clinical trials and future potential of targeted therapy for ovarian cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22933245&form=6&db=m Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22946318&form=6&db=m [Poly(ADP-ribose) polymerase (PARP): physiological and pathological roles]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22955851&form=6&db=m Erythropoietin-driven signalling and cell migration mediated by polyADP-ribosylation. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22957017&form=6&db=m Trichosanthin inhibits breast cancer cell proliferation in both cell lines and nude mice by promotion of apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22959823&form=6&db=m 1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and activates apoptosis in melanoma. causal interaction,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22962264&form=6&db=m Targeting BRCA1 localization to augment breast tumor sensitivity to poly(ADP-ribose) polymerase inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22965279&form=6&db=m Induction of non-small cell lung carcinoma apoptosis using soluble RGD-TRAIL by targeting the integrin receptor of tumor cells. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22983061&form=6&db=m Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22987487&form=6&db=m HER2 Overexpression Renders Human Breast Cancers Sensitive to PARP Inhibition Independently of Any Defect in Homologous Recombination DNA Repair. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22993403&form=6&db=m Dual roles of PARP-1 promote cancer growth and progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23054213&form=6&db=m The PARP inhibitor ABT-888 synergizes irinotecan treatment of colon cancer cell lines. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23066914&form=6&db=m Design, synthesis and biological evaluation of cinnamic acyl shikonin derivatives. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23071261&form=6&db=m Molecular pathways: understanding the role of Rad52 in homologous recombination for therapeutic advancement. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23073772&form=6&db=m Racial and tissue-specific cancer risk associated with PARP1 (ADPRT) Val762Ala polymorphism: a meta-analysis. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23087057&form=6&db=m Loss of PPP2R2A inhibits homologous recombination DNA repair and predicts tumor sensitivity to PARP inhibition. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23103855&form=6&db=m Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23110154&form=6&db=m Mutation analysis of BRCA1, BRCA2, PALB2 and BRD7 in a hospital-based series of German patients with triple-negative breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23114871&form=6&db=m Ovarian cancer cells, not normal cells, are damaged by Mirk/Dyrk1B kinase inhibition. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23118055&form=6&db=m Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23142291&form=6&db=m Therapy of Smac mimetic SM-164 in combination with gemcitabine for pancreatic cancer. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23148373&form=6&db=m The promise of combining inhibition of PI3K and PARP as cancer therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23148997&form=6&db=m Optimize radiochemotherapy in pancreatic cancer: PARP inhibitors a new therapeutic opportunity. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23153706&form=6&db=m Targeting epidermal growth factor receptor/human epidermal growth factor receptor 2 signalling pathway by a dual receptor tyrosine kinase inhibitor afatinib for radiosensitisation in murine bladder carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23157593&form=6&db=m NF?B Down-regulation and PARP Cleavage by Novel 3-?-Butyryloxy-?-boswellic Acid Results in Cancer Cell Specific Apoptosis and in vivo Tumor Regression. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23161221&form=6&db=m Enhanced suppression of proliferation and migration in highly-metastatic lung cancer cells by combination of valproic acid and coumarin-3-carboxylic acid and its molecular mechanisms of action. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23165508&form=6&db=m Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23166634&form=6&db=m Spirooxindole derivative SOID-8 induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23187903&form=6&db=m Labeling Substrate Proteins of Poly(ADP-ribose) Polymerases with Clickable NAD Analog. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23193155&form=6&db=m Predicting enhanced cell killing through PARP inhibition. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23243059&form=6&db=m Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23251575&form=6&db=m Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to Cisplatin and poly (adp-ribose) polymerase inhibition. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23254695&form=6&db=m Inhibition of poly(ADP-ribose) polymerase-1 or poly(ADP?ribose) glycohydrolase individually, but not in combination, leads to improved chemotherapeutic efficacy in HeLa cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23259582&form=6&db=m Drugging topoisomerases: lessons and challenges. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23269547&form=6&db=m Molecular Pathways: Targeting PARP in Cancer Treatment. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23275151&form=6&db=m PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23293602&form=6&db=m Is there an epigenetic component underlying the resistance of triple-negative breast cancers to parp inhibitors? causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23301673&form=6&db=m PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23315029&form=6&db=m Evaluation of the pharmacodynamics and pharmacokinetics of the PARP inhibitor olaparib: a Phase I multicentre trial in patients scheduled for elective breast cancer surgery. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23321033&form=6&db=m Targeting triple negative breast cancer: Is p53 the answer? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23328638&form=6&db=m Concordance of ATM (Ataxia Telangiectasia Mutated) Immunohistochemistry between Biopsy or Metastatic Tumor Samples and Primary Tumors in Gastric Cancer Patients. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23333522&form=6&db=m Synthetic lethality and cancer: cohesin and PARP at the replication fork. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23340716&form=6&db=m Bortezomib-enhanced radiosensitization through the suppression of radiation-induced nuclear factor-?B activity in human oral cancer cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23349304&form=6&db=m Microsatellite instability induced mutations in DNA repair genes Ctip and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors in myeloidmalignancies. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23353747&form=6&db=m Cytotoxicity of lapachol, ?-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23370117&form=6&db=m Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23377138&form=6&db=m Sirtuins in dermatology: applications for future research and therapeutics. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23379721&form=6&db=m PARP inhibitors in cancer therapy: an update. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23388117&form=6&db=m The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23393227&form=6&db=m Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23396107&form=6&db=m Inhibition of Poly(ADP-Ribose) Polymerase Enhances Radiochemosensitivity in Cancers Proficient in DNA Double-Strand Break Repair. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23405229&form=6&db=m The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23410825&form=6&db=m PARP1 impact on DNA repair of platinum adducts: Preclinical and clinical read-outs. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23415900&form=6&db=m Inhibition of gastric tumor growth by a novel Hsp90 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23422672&form=6&db=m Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23430782&form=6&db=m Cadmium and cancer. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23436410&form=6&db=m PARP Inhibition as a Prototype for Synthetic Lethal Screens. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23450678&form=6&db=m Resistance to PARP-Inhibitors in Cancer Therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23451039&form=6&db=m New Approaches of PARP-1 Inhibitors in Human Lung Cancer Cells and Cancer Stem-Like Cells by Some Selected Anthraquinone-Derived Small Molecules. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23452595&form=6&db=m [c-MYC, PARP1 and BIN1 as targets for therapy of cancer cell resistance]. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23475955&form=6&db=m Bcl-2/Bcl-xL Inhibition Increases the Efficacy of Mek Inhibition Alone and in Combination with PI3 Kinase Inhibition in Lung and Pancreatic Tumor Models. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23486608&form=6&db=m PARP expression in germ cell tumours. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23510353&form=6&db=m Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23512992&form=6&db=m RAD51C-deficient cancer cells are highly sensitive to the poly (ADP-ribose) polymerase inhibitor, olaparib. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23523951&form=6&db=m Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23533664&form=6&db=m Resveratrol Induces Premature Senescence in Lung Cancer Cells via ROS-Mediated DNA Damage. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23536467&form=6&db=m Total Synthesis and Biological Evaluation of Grassypeptolide?A. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23554447&form=6&db=m Cisplatin resistance associated with PARP hyperactivation. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23565244&form=6&db=m PARP inhibition sensitizes to low dose-rate radiation TMPRSS2-ERG fusion gene-expressing and PTEN-deficient prostate cancer cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23567619&form=6&db=m NVP-LDE-225 (Erismodegib) inhibits epithelial-mesenchymal transition and human prostate cancer stem cell growth in NOD/SCID IL2R? null mice by regulating Bmi-1 and microRNA-128. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23575687&form=6&db=m Regulation of NF-?B signalling by the mono-ADP-ribosyltransferase ARTD10. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23587053&form=6&db=m No evidence for PALB2 methylation in high-grade serous ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23590234&form=6&db=m A role of intracellular mono-ADP-ribosylation in cancer biology. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23591868&form=6&db=m Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23595559&form=6&db=m Human V?2V?2 T cells limit breast cancer growth by modulating cell survival-, apoptosis-related molecules and microenvironment in tumors. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23601167&form=6&db=m PARP inhibitors: polypharmacology versus selective inhibition. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23631432&form=6&db=m Quantification of cellular poly(ADP-ribosyl)ation by stable isotope dilution mass spectrometry reveals tissue- and drug-dependent stress response dynamics. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23637762&form=6&db=m Diet-induced obesity exacerbates auditory degeneration via hypoxia, inflammation, and apoptosis signaling pathways in CD/1 mice. diagnostic usage,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23653048&form=6&db=m Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23656790&form=6&db=m Oncogenic miR-181a/b affect the DNA damage response in aggressive breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23666561&form=6&db=m Curcumin targets the AKT-mTOR pathway for uterine leiomyosarcoma tumor growth suppression. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23684930&form=6&db=m Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23711929&form=6&db=m Quercetin-3-O-(2"-galloyl)-?-l-rhamnopyranoside prevents TRAIL-induced apoptosis in human keratinocytes by suppressing the caspase-8- and Bid-pathways and the mitochondrial pathway. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23714734&form=6&db=m Poly(ADP-ribosyl)ation in carcinogenesis. causal interaction,diagnostic usage,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23736962&form=6&db=m Variations in the mRNA expression of poly(ADP-ribose) polymerases, poly(ADP-ribose) glycohydrolase and ADP-ribosylhydrolase 3 in breast tumors and impact on clinical outcome. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23739867&form=6&db=m Expression profiles of vault components MVP, TEP1 and vPARP and their correlation to other multidrug resistance proteins in ovarian cancer. causal interaction,diagnostic usage,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23747892&form=6&db=m Poly(ADP-ribose) polymerase inhibitors as cancer therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23760205&form=6&db=m TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23760496&form=6&db=m Comparative antiproliferative effects of iniparib and olaparib on a panel of triple-negative and non-triple-negative breast cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23785295&form=6&db=m PARP-1 regulates metastatic melanoma through modulation of vimentin-induced malignant transformation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23806212&form=6&db=m Trichodermin induces cell apoptosis through mitochondrial dysfunction and endoplasmic reticulum stress in human chondrosarcoma cells. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23807292&form=6&db=m Poly (ADP-ribose) polymerase 1 protein expression in normal and neoplastic prostatic tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23810788&form=6&db=m The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23825154&form=6&db=m Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23827475&form=6&db=m Polylysine-modified polyethylenimine inducing tumor apoptosis as an efficient gene carrier. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23847380&form=6&db=m Olaparib shows promise in multiple tumor types. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23883585&form=6&db=m Catalase Abrogates ?-Lapachone-Induced PARP1 Hyperactivation-Directed Programmed Necrosis in NQO1-Positive Breast Cancers. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23888686&form=6&db=m [Research progresses of the PARP inhibitors for the treatment of cancer]. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23893925&form=6&db=m The role of thiamine in cancer: possible genetic and cellular signaling mechanisms. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23898832&form=6&db=m Inhibitory Effects of Different Forms of Tocopherols, Tocopherol Phosphates, and Tocopherol Quinones on Growth of Colon Cancer Cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23899790&form=6&db=m Post-traumatic caspase-3 expression in the adjacent areas of growth plate injury site: a morphological study. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23910651&form=6&db=m Reduced ADP-ribosylation by PARP1 natural polymorphism V762A and by PARP1 inhibitors enhance Hepatitis B virus replication. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23913164&form=6&db=m Tyrosyl-DNA phosphodiesterase 1 (TDP1) and Poly (ADP-Ribose) Polymerase-1 (PARP1) deficiency are cytotoxic to rhabdomyosarcoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23917378&form=6&db=m PARP and CHK inhibitors interact to cause DNA damage and cell death in mammary carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23921685&form=6&db=m Post-transcriptional regulation by poly(ADP-ribosyl)ation of the RNA-binding proteins. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23936501&form=6&db=m Trichothecin induces cell death in NF-?B constitutively activated human cancer cells via inhibition of IKK? phosphorylation. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23957916&form=6&db=m Parp-1 deficiency in ES cells promotes invasive and metastatic lesions accompanying induction of trophoblast giant cells during tumorigenesis in uterine environment. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23960188&form=6&db=m DNA repair genes are selectively mutated in diffuse large B cell lymphomas. causal interaction,diagnostic usage,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23963802&form=6&db=m Vitamin E ?-Tocotrienol Prolongs Survival in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) Transgenic Mouse Model of Pancreatic Cancer. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23966622&form=6&db=m Combining poly(ADP-ribose) polymerase 1 (PARP-1) inhibition and radiation in Ewings sarcoma results in lethal DNA damage. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23988612&form=6&db=m Targeted therapy for breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23995751&form=6&db=m Cell death associated with abnormal mitosis observed by confocal imaging in live cancer cells. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24025361&form=6&db=m A novel synthetic derivative of the natural product berbamine inhibits cell viability and induces apoptosis of human osteosarcoma cells, associated with activation of JNK/AP-1 signaling. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24033642&form=6&db=m Involvement of homologous recombination in the synergism between cisplatin and poly(ADP-ribose) polymerase inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24037533&form=6&db=m Predictive biomarkers for cancer therapy with PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24038812&form=6&db=m Preclinical evaluation of the PARP inhibitor, olaparib, in combination with cytotoxic chemotherapy in pediatric solid tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24039967&form=6&db=m Searching in mother nature for anti-cancer activity: anti-proliferative and pro-apoptotic effect elicited by green barley on leukemia/lymphoma cells. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24056306&form=6&db=m Exploring the effect of PARP-1 flexibility in docking studies. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24062981&form=6&db=m The Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24069582&form=6&db=m Targeted Therapy for Breast Cancer Prevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24080249&form=6&db=m Novel roles of 1?,25(OH)2D3 on DNA repair provide new strategies for breast cancer treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24085778&form=6&db=m Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24097104&form=6&db=m Putting poly (ADP-ribose) polymerase and other DNA repair inhibitors into clinical practice. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24098868&form=6&db=m The Role of PARP Inhibitors in the Treatment of Gynecologic Malignancies. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24099794&form=6&db=m Novel Compound 1, 3-bis (3, 5-dichlorophenyl) urea Inhibits Lung Cancer Progression. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24100507&form=6&db=m MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cells. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24131965&form=6&db=m BRCA1- and BRCA2-related mutations: therapeutic implications in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24132498&form=6&db=m Suppression of proliferation and migration in highly-metastatic lung cancer cells as well as tumor growth by a new synthesized compound TBrC and its molecular mechanisms of action. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24137565&form=6&db=m Strategic Combination of DNA-Damaging Agent and PARP Inhibitor Results in Enhanced Cytotoxicity. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24164298&form=6&db=m H2AX a promising biomarker for lung cancer: a review. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24171773&form=6&db=m From polypharmacology to target specificity: the case of PARP inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24176499&form=6&db=m Different T cell memory in preadolescents after whole-cell or acellular pertussis vaccination. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24179537&form=6&db=m Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24189460&form=6&db=m Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24191908&form=6&db=m BRCA1 promoter hypermethylation, 53BP1 protein expression and PARP-1 activity as biomarkers of DNA repair deficit in breast cancer. diagnostic usage,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24191958&form=6&db=m PARP inhibitors: an interesting pathway also for Non-Small Cell Lung Cancer? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24202328&form=6&db=m PARP-1: Friend or Foe of DNA Damage and Repair in Tumorigenesis? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24203816&form=6&db=m Two DNA repair gene polymorphisms on the risk of gastrointestinal cancers: a meta-analysis. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24204199&form=6&db=m Targeted radiosensitization of ETS fusion-positive prostate cancer through PARP1 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24211075&form=6&db=m A cationic cholesterol based nanocarrier for the delivery of p53-EGFP-C3 plasmid to cancer cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24219164&form=6&db=m Effect of a poly(ADP-ribose) polymerase-1 inhibitor against esophageal squamous cell carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24222661&form=6&db=m Low levels of circulating estrogen sensitize PTEN-null endometrial tumors to PARP inhibition in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24225019&form=6&db=m PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24231340&form=6&db=m ?-Tocotrienol-induced autophagy in malignant mammary cancer cells. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24237241&form=6&db=m Discussion of PARP inhibitors in cancer therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24252502&form=6&db=m ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24270682&form=6&db=m Molecular pathways: how can BRCA-mutated tumors become resistant to PARP inhibitors? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24294592&form=6&db=m PARP Inhibitors in Cancer Therapy: Magic Bullets but Moving Targets. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24317580&form=6&db=m Natural and glucosyl flavonoids inhibit poly(ADP-ribose) polymerase activity and induce synthetic lethality in BRCA mutant cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24333214&form=6&db=m SP600125 overcomes antimitotic drug-resistance in cancer cells by increasing apoptosis with independence of P-gp inhibition. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24335147&form=6&db=m TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24336406&form=6&db=m Mitochondrial DNA depletion sensitizes cancer cells to PARP inhibitors by translational and post-translational repression of BRCA2. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24337974&form=6&db=m Pyrosequencing analysis of BRCA1 methylation level in breast cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24350055&form=6&db=m Beyond DNA Repair: Additional Functions of PARP-1 in Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24356813&form=6&db=m Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24356817&form=6&db=m Glioblastoma Cells Containing Mutations in the Cohesin Component STAG2 Are Sensitive to PARP Inhibition. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24361480&form=6&db=m Platinated benzonaphthyridone is a stronger inhibitor of poly(ADP-ribose) polymerase-1 and a more potent anticancer agent than is the parent inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24373880&form=6&db=m Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24378347&form=6&db=m The CDK1 inhibitor RO3306 improves the response of BRCA-pro?cient breast cancer cells to PARP inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24382396&form=6&db=m Development and validation of high-throughput screening assays for poly(ADP-ribose) polymerase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24387337&form=6&db=m Targeting the BRCA1/2 tumor suppressors. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24392349&form=6&db=m Structural Implications for Selective Targeting of PARPs. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24397478&form=6&db=m DNA damage response genes and the development of cancer metastasis. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24398405&form=6&db=m Casein kinase 2 inhibition attenuates cholesterol oxidation product-induced apoptosis by suppressing the activation of the mitochondrial pathway and the caspase-8- and bid-dependent pathways. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24415413&form=6&db=m Development of breast tumors in CHEK2, NBN/NBS1 and BLM mutation carriers does not commonly involve somatic inactivation of the wild-type allele. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24419059&form=6&db=m CBP-Mediated FOXO-1 Acetylation Inhibits Pancreatic Tumor Growth by Targeting SirT. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24420152&form=6&db=m INPP4B overexpression enhances the antitumor efficacy of PARP inhibitor AG014699 in MDA-MB-231 triple-negative breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24436031&form=6&db=m Expression of PARP-1 and its active polymer PAR in prostate cancer and benign prostatic hyperplasia in Chinese patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24473064&form=6&db=m PCAT-1, a Long Noncoding RNA, Regulates BRCA2 and Controls Homologous Recombination in Cancer. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24484288&form=6&db=m Targeting DNA damage response in cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24486850&form=6&db=m Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: Preclinical and clinical evidence. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24489833&form=6&db=m Association between the PARP1 Val762Ala polymorphism and cancer risk: evidence from 43 studies. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24503274&form=6&db=m Synthesis, [¹?F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24504413&form=6&db=m Minor grove binding ligands disrupt PARP-1 activation pathways. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24528514&form=6&db=m Poly (ADP-ribose) polymerase 3 (PARP3), a potential repressor of telomerase activity. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24535435&form=6&db=m Gentian violet induces wtp53 transactivation in cancer cells. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24535833&form=6&db=m Inherited variation in the PARP1 gene and survival from melanoma. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24556618&form=6&db=m Tumour cell retention of rucaparib, sustained PARP inhibition and efficacy of weekly as well as daily schedules. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24563182&form=6&db=m Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24577941&form=6&db=m The use of olaparib (AZD2281) potentiates SN-38 cytotoxicity in colon cancer cells by indirect inhibition of Rad51-mediated repair of DNA double-strand breaks. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24579064&form=6&db=m BRCA 1/2-Mutation Related and Sporadic Breast and Ovarian Cancers: More Alike than Different. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24579667&form=6&db=m Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24586933&form=6&db=m Role of the ERK pathway for oxidant-induced parthanatos in human lymphocytes. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24607283&form=6&db=m PARP inhibitors in ovarian cancer: Current status and future promise. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24616882&form=6&db=m Beyond Breast and Ovarian Cancers: PARP Inhibitors for BRCA Mutation-Associated and BRCA-Like Solid Tumors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24625059&form=6&db=m Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24631255&form=6&db=m Baicalein attenuates proteasome inhibition-induced apoptosis by suppressing the activation of the mitochondrial pathway and the caspase-8- and Bid-dependent pathways. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24631446&form=6&db=m Suberoylanilide hydroxamic acid (SAHA) enhances olaparib activity by targeting homologous recombination DNA repair in ovarian cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24650937&form=6&db=m Rationale for PARP inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24675890&form=6&db=m Doxorubicin enhances Snail/LSD1-mediated PTEN suppression in a PARP1-dependent manner. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24676941&form=6&db=m Synergistic effect of arginine-specific ADP-ribosyltransferase 1 and poly(ADP-ribose) polymerase-1 on apoptosis induced by cisplatin in CT26 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24682826&form=6&db=m A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24689236&form=6&db=m [Synthesis and activity evaluation of PARP-1 inhibitors with azaindole skeleton]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24694877&form=6&db=m Embelin Suppresses Growth of Human Pancreatic Cancer Xenografts, and Pancreatic Cancer Cells Isolated from KrasG12D Mice by Inhibiting Akt and Sonic Hedgehog Pathways. causal interaction,diagnostic usage,unassigned 2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24698998&form=6&db=m DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24712325&form=6&db=m Drug Target Strategies in Breast Cancer Treatment: Recent Developments. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24726141&form=6&db=m The Histone Methyltransferase SMYD2 Methylates PARP1 and Promotes Poly(ADP-ribosyl)ation Activity in Cancer Cells. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24727894&form=6&db=m ?-Catenin, a Wnt/?-catenin modulator, reveals inducible mutagenesis promoting cancer cell survival adaptation and metabolic reprogramming. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24735547&form=6&db=m Linifanib (ABT-869), enhances cytotoxicity with poly (ADP-ribose) polymerase inhibitor, veliparib (ABT-888), in head and neck carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24740818&form=6&db=m Exogenous fatty acid binding protein 4 promotes human prostate cancer cell progression. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24742967&form=6&db=m Strigolactone analogues induce apoptosis through activation of p38 and the stress response pathway in cancer cell lines and in conditionally reprogrammed primary prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24748377&form=6&db=m Pathway-specific engineered mouse allograft models functionally recapitulate human serous epithelial ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24764124&form=6&db=m Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24778008&form=6&db=m Advanced epithelial ovarian cancer: from standard chemotherapy to promising molecular pathway targets--where are we now? causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24784564&form=6&db=m Indoleamine 2,3-dioxygenase mediates immune-independent human tumor cell resistance to olaparib, gamma radiation, and cisplatin. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24817481&form=6&db=m The PARP inhibitors, veliparib and olaparib, are effective chemopreventive agents for delaying mammary tumor development in BRCA1-deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24830722&form=6&db=m Slug promotes survival during metastasis through suppression of Puma-mediated apoptosis. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24831086&form=6&db=m Phosphorylation of ribosomal protein S6 confers PARP inhibitor resistance in BRCA1-deficient cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24831963&form=6&db=m A novel PI3K inhibitor displays potent preclinical activity against an androgen-independent and PTEN-deficient prostate cancer model established from the cell line PC3. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24841718&form=6&db=m Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24844596&form=6&db=m An ex vivo assay of XRT-induced Rad51 foci formation predicts response to PARP-inhibition in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24853559&form=6&db=m PARP-1 Val762Ala polymorphism and risk of cancer: a meta-analysis based on 39 case-control studies. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24856976&form=6&db=m B-lymphoblastic leukemia/lymphoma: overexpression of nuclear DNA repair protein PARP-1 correlates with antiapoptotic protein Bcl-2 and complex chromosomal abnormalities. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24867710&form=6&db=m In vivo imaging of specific drug-target binding at subcellular resolution. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24874429&form=6&db=m Rapamycin-resistant PARP1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis (LAM). causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24876881&form=6&db=m In Silico Investigation of Potential PARP-1 Inhibitors from Traditional Chinese Medicine. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24878761&form=6&db=m Function and Regulation of the Mono-ADP-Ribosyltransferase ARTD10. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24880570&form=6&db=m Phase 1 dose-escalation study of the PARP inhibitor CEP-9722 as monotherapy or in combination with temozolomide in patients with solid tumors. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24889936&form=6&db=m Parp-1 genetic ablation in Ela-myc mice unveils novel roles for Parp-1 in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24895135&form=6&db=m Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24898058&form=6&db=m New PARP targets for cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24909753&form=6&db=m Structure elucidation and biological activity of two new trichothecenes from an endophyte, Myrothecium roridum. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24916104&form=6&db=m Transcriptional roles of PARP1 in cancer. diagnostic usage,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24916412&form=6&db=m Insights into PARP Inhibitors' Selectivity Using Fluorescence Polarization and Surface Plasmon Resonance Binding Assays. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24927325&form=6&db=m Effect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vitro. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24937370&form=6&db=m PARP inhibitor attenuated colony formation can be restored by MAP kinase inhibitors in different irradiated cancer cell lines. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24939750&form=6&db=m Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24956560&form=6&db=m Association of PARP-1, NF-?B, NF-?BIA and IL-6, IL-1? and TNF-? with Graves Disease and Graves Ophthalmopathy. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24958807&form=6&db=m Molecular Pathways: Targeting ETS Gene Fusions in Cancer. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24962108&form=6&db=m Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24963051&form=6&db=m Functional Ex Vivo Assay to Select Homologous Recombination-Deficient Breast Tumors for PARP Inhibitor Treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24969859&form=6&db=m Endpoint of cancer treatment: targeted therapies. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24970803&form=6&db=m Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25014793&form=6&db=m Activation of Poly(ADP-Ribose) Polymerase-1 Delays Wound Healing by Regulating Keratinocyte Migration and Production of Inflammatory Mediators. diagnostic usage,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25016056&form=6&db=m Anticancer activity of HS-527, a novel inhibitor targeting PI3-kinase in human pancreatic cancer cells. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25017803&form=6&db=m Poly (ADP-ribose) polymerase inhibitor efficacy in head and neck cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25018892&form=6&db=m Radiosensitivity and Induction of Apoptosis by High LET Carbon Ion Beam and Low LET Gamma Radiation: A Comparative Study. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25026313&form=6&db=m Inhibition of poly(ADP-ribosyl)ation in cancer: old and new paradigms revisited. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25038569&form=6&db=m 2-[5-Selenocyanato-pentyl]-6-amino-benzo[de]isoquinoline-1,3-dione inhibits angiogenesis, induces p53 dependent mitochondrial apoptosis and enhances therapeutic efficacy of cyclophosphamide. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25050737&form=6&db=m Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25054302&form=6&db=m The potential of PARP inhibitors in neuro-oncology. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25059577&form=6&db=m Post-Traumatic Brain Injury: Genetic Susceptibility to Outcome. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25062913&form=6&db=m Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25066396&form=6&db=m Inhibited effects of veliparib combined doxorubicin for BEL-7404 proliferation of human liver cancer cell line. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25077527&form=6&db=m Induction of necrosis in human liver tumor cells by ?-phellandrene. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25078326&form=6&db=m The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity. diagnostic usage,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25083618&form=6&db=m Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25085902&form=6&db=m Modulation of the poly (ADP-ribose) polymerase inhibitor response and DNA recombination in breast cancer cells by drugs affecting endogenous wild-type p53. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25093514&form=6&db=m Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25097306&form=6&db=m Telomere instability in papillary bladder urothelial carcinomas: Comparison with grading and risk of recurrence. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25103497&form=6&db=m TGF? induces "BRCAness" and sensitivity to PARP inhibition in breast cancer by regulating DNA-repair genes. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25107705&form=6&db=m Mitochondrial dysfunction in cancer chemoresistance. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25111287&form=6&db=m Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers? diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25114899&form=6&db=m Sensitization of cancer cells through reduction of total Akt and downregulation of salinomycin-induced pAkt, pGSk3?, pTSC2, and p4EBP1 by cotreatment with MK-2206. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25118896&form=6&db=m Poly(ADP-ribose) polymerase-1 (PARP1) and p53 labelling index correlates with tumour grade in meningiomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25127709&form=6&db=m Synergistic loss of prostate cancer cell viability by coinhibition of HDAC and PARP. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25131201&form=6&db=m A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25139258&form=6&db=m PARP inhibitor olaparib increases the oncolytic activity of dl922-947 in in vitro and in vivo model of anaplastic thyroid carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25139788&form=6&db=m PARP inhibition and the radiosensitizing effects of the PARP inhibitor ABT-888 in in vitro hepatocellular carcinoma models. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25158060&form=6&db=m Evolution of pre-existing versus acquired resistance to platinum drugs and PARP inhibitors in BRCA-associated cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25173886&form=6&db=m PARP-1 regulates epithelial-mesenchymal transition (EMT) in prostate tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25183353&form=6&db=m Structural requirements of some 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide derivatives as poly (ADP-ribose) polymerase (PARP) for the treatment of cancer: QSAR approach. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25199458&form=6&db=m PARP and other prospective targets for poisoning cancer cell metabolism. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25220415&form=6&db=m The role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25257171&form=6&db=m Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ation. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25262797&form=6&db=m A review on PARP1 inhibitors: Pharmacophore modeling, virtual and biological screening studies to identify novel PARP1 inhibitors. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25268610&form=6&db=m Effect of APE1 T2197G (Asp148Glu) polymorphism on APE1, XRCC1, PARP1 and OGG1 expression in patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25273175&form=6&db=m Rotundarpene prevents TRAIL-induced apoptosis in human keratinocytes by suppressing the caspase-8- and Bid-pathways and the mitochondrial pathway. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25286857&form=6&db=m Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25286972&form=6&db=m An update on PARP inhibitors--moving to the adjuvant setting. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25295271&form=6&db=m KML001, a telomere-targeting drug, sensitizes glioblastoma cells to temozolomide chemotherapy and radiotherapy through DNA damage and apoptosis. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25299774&form=6&db=m Neuroglobin, a pro-survival player in estrogen receptor ?-positive cancer cells. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25299784&form=6&db=m Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25302833&form=6&db=m New therapeutic perspectives in CCDC6 deficient lung cancer cells. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25310109&form=6&db=m Celastrol induces the apoptosis of breast cancer cells and inhibits their invasion via downregulation of MMP-9. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25310643&form=6&db=m MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25341009&form=6&db=m Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25342917&form=6&db=m Novel treatment strategies in triple-negative breast cancer: specific role of poly(adenosine diphosphate-ribose) polymerase inhibition. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25346248&form=6&db=m Probing PARP1-inhibitor complexes for the development of novel inhibitors. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25350685&form=6&db=m Stepwise development of structure-activity relationship of diverse PARP-1 inhibitors through comparative and validated in silico modeling techniques and molecular dynamics simulation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25351371&form=6&db=m PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25355929&form=6&db=m A Phase I study of veliparib (ABT-888) in combination with low-dose fractionated whole abdominal radiation therapy in patients with advanced solid malignancies and peritoneal carcinomatosis. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25372309&form=6&db=m PARP1 and CBP lose their footing in cancer. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25416589&form=6&db=m Identification by array comparative genomic hybridization of a new amplicon on chromosome 17q highly recurrent in BRCA1 mutated triple negative breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25418925&form=6&db=m Curcumin Combined with Oxaliplatin Effectively Suppress Colorectal Carcinoma in vivo Through Inducing Apoptosis. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25441760&form=6&db=m [PARP inhibitors and radiotherapy: rational and prospects for a clinical use]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25451105&form=6&db=m Molecular pathways: exploiting tumor-specific molecular defects in DNA repair pathways for precision cancer therapy. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25456211&form=6&db=m AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25476842&form=6&db=m Flavanonol taxifolin attenuates proteasome inhibition-induced apoptosis in differentiated PC12 cells by suppressing cell death process. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25477519&form=6&db=m A Quantitative Assay Reveals Ligand Specificity of the DNA Scaffold Repair Protein XRCC1 and Efficient Disassembly of Complexes of XRCC1 and the Poly(ADP-ribose) Polymerase 1 by Poly(ADP-ribose) Glycohydrolase. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25477992&form=6&db=m In vivo and in vitro antitumor effects of platycodin d, a saponin purified from platycodi radix on the h520 lung cancer cell. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25483710&form=6&db=m BRCA1, PARP1 and ?H2AX in acute myeloid leukemia: Role as biomarkers of response to the PARP inhibitor olaparib. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25500058&form=6&db=m Synergistic Activity of PARP Inhibition by Talazoparib (BMN 673) with Temozolomide in Pediatric Cancer Models in the Pediatric Preclinical Testing Program. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25510629&form=6&db=m Synthesis and anticancer activities of a novel class of mono- and di-metallic Pt(II)(salicylaldiminato)(DMSO or Picolino)Cl complexes. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25511378&form=6&db=m BRCA2-Deficient Sarcomatoid Mammary Tumors Exhibit Multidrug Resistance. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25526641&form=6&db=m PARP-1 expression is increased in colon adenoma and carcinoma and correlates with OGG1. causal interaction,diagnostic usage,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25526776&form=6&db=m A phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA defective tumours: a study protocol. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25528020&form=6&db=m Biological and clinical significance of PARP1 protein expression in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25555679&form=6&db=m RecQ helicases and PARP1 team up in maintaining genome integrity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,2 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25565365&form=6&db=m A Small-Molecule Protein-Protein Interaction Inhibitor of PARP1 That Targets Its BRCT Domain. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25576921&form=6&db=m PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant glioma. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25583207&form=6&db=m DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25583815&form=6&db=m Olaparib effective in four advanced cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25589624&form=6&db=m Randomized Trial of Oral Cyclophosphamide and Veliparib in High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers, or BRCA-Mutant Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25592323&form=6&db=m Rotundarpene attenuates cholesterol oxidation product-induced apoptosis by suppressing the mitochondrial pathway and the caspase-8- and bid-dependent pathways. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25604309&form=6&db=m Novel poly (ADP-ribose) polymerase inhibitor, AZD2281, enhances radiosensitivity of both normoxic and hypoxic esophageal squamous cancer cells. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25604534&form=6&db=m Deciphering the Insights of Poly(ADP-Ribosylation) in Tumor Progression. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25607248&form=6&db=m Poly-ADP-ribosylation of HMGB1 regulates TNFSF10/TRAIL resistance through autophagy. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25616434&form=6&db=m Olaparib: first global approval. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25621047&form=6&db=m JF-305, a pancreatic cancer cell line is highly sensitive to the PARP inhibitor olaparib. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25628946&form=6&db=m Methylation of tumor suppressor genes is related with copy number aberrations in breast cancer. diagnostic usage,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25633290&form=6&db=m Targeting MKK3 as a novel anticancer strategy: molecular mechanisms and therapeutical implications. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25634209&form=6&db=m Interaction of BARD1 and HP1 is required for BRCA1 retention at sites of DNA damage. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25667043&form=6&db=m Effect of poly(ADP-ribose)polymerase and DNA topoisomerase I inhibitors on the p53/p63-dependent survival of carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25667168&form=6&db=m The combination of the PARP inhibitor rucaparib and 5FU is an effective strategy for treating acute leukemias. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25682949&form=6&db=m Artocarpus altilis (Parkinson) Fosberg Extracts and Geranyl Dihydrochalcone Inhibit STAT3 Activity in Prostate Cancer DU145 Cells. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25686825&form=6&db=m NF-kB signaling mediates acquired resistance after PARP inhibition. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25689628&form=6&db=m Vasoactivity of Rucaparib, a PARP-1 Inhibitor, is a Complex Process that Involves Myosin Light Chain Kinase, P2 Receptors, and PARP Itself. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25690937&form=6&db=m DNA damage response markers are differentially expressed in BRCA-mutated breast cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25708226&form=6&db=m PARP inhibitors: A new era of targeted therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25725131&form=6&db=m Two decades beyond BRCA1/2: Homologous recombination, hereditary cancer risk and a target for ovarian cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25750544&form=6&db=m An update on PARP inhibitors for the treatment of cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25757679&form=6&db=m Olaparib: an oral PARP-1 and PARP-2 inhibitor with promising activity in ovarian cancer. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25758918&form=6&db=m Trapping PARP. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25761096&form=6&db=m Niraparib: A Poly(ADP-ribose) Polymerase (PARP) Inhibitor for the Treatment of Tumors with Defective Homologous Recombination. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25774912&form=6&db=m Protein expression of DNA damage repair proteins dictates response to topoisomerase and PARP inhibitors in triple-negative breast cancer. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25777962&form=6&db=m MGMT Expression Predicts PARP-Mediated Resistance to Temozolomide. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25779917&form=6&db=m Expression of human poly (ADP-ribose) polymerase 1 in Saccharomyces cerevisiae: Effect on survival, homologous recombination and identification of genes involved in intracellular localization. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25779944&form=6&db=m The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25799992&form=6&db=m REV7 counteracts DNA double-strand break resection and affects PARP inhibition. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25806124&form=6&db=m Cisplatin induces primary necrosis through poly(ADP-ribose) polymerase 1 activation in kidney proximal tubular cells. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25808111&form=6&db=m Expression of nuclear matrix proteins binding matrix attachment regions in prostate cancer. PARP-1: New player in tumor progression. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25811344&form=6&db=m Sequences and combinations of multifaceted therapy in advanced prostate cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25811737&form=6&db=m Genomic profiling in locally advanced and inflammatory breast cancer and its link to DCE-MRI and overall survival. diagnostic usage,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25818403&form=6&db=m A phase II evaluation of the potent, highly selective PARP inhibitor veliparib in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients who carry a germline BRCA1 or BRCA2 mutation - An NRG Oncology/Gynecologic Oncology Group study. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25833211&form=6&db=m PARP1 and phospho-p65 protein expression is increased in human HER2-positive breast cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25833690&form=6&db=m Gemcitabine impacts differentially on bladder and kidney cancer cells: distinct modulations in the expression patterns of apoptosis-related microRNAs and BCL2 family genes. diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25839806&form=6&db=m A polysaccharide from Trametes robiniophila inhibits human osteosarcoma xenograft tumor growth in vivo. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25841766&form=6&db=m Targeting Nrf2 in healthy and malignant ovarian epithelial cells: Protection versus promotion. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25842967&form=6&db=m Cyclic hypoxia does not alter RAD51 expression or PARP inhibitor cell kill in tumor cells. causal interaction,ongoing research,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25847771&form=6&db=m Towards small molecule inhibitors of mono-ADP-ribosyltransferases. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25848691&form=6&db=m Functional Characterization of Long Noncoding RNA Lnc_bc060912 in Human Lung Carcinoma Cells. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25865228&form=6&db=m Autoimmune response to PARP and BRCA1/BRCA2 in cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25868852&form=6&db=m Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25878361&form=6&db=m RAS Synthetic Lethal Screens Revisited: Still Seeking the Elusive Prize? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25883215&form=6&db=m Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25888415&form=6&db=m Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti-tumor effects of the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib in triple-negative breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25895168&form=6&db=m Dual-Modality Optical/PET Imaging of PARP1 in Glioblastoma. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25915038&form=6&db=m Activating the Wnt/?-Catenin Pathway for the Treatment of Melanoma--Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25934569&form=6&db=m PJ-34 inhibits PARP-1 expression and ERK phosphorylation in glioma-conditioned brain microvascular endothelial cells. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25938539&form=6&db=m PARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expression. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25940138&form=6&db=m Acyl-CoA-binding domain containing 3 modulates NAD+ metabolism through activating poly(ADP-ribose) polymerase 1. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25981132&form=6&db=m Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25984718&form=6&db=m Single cell resolution in vivo imaging of DNA damage following PARP inhibition. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25993149&form=6&db=m Chemotherapy for Patients with BRCA1 and BRCA2-Mutated Ovarian Cancer: Same or Different? diagnostic usage,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25999161&form=6&db=m Identification and mechanism of action analysis of the new PARP-1 inhibitor 2?-hydroxygenkwanol A. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26004342&form=6&db=m Curcumin inhibits PhIP induced cytotoxicity in breast epithelial cells through multiple molecular targets. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26015868&form=6&db=m Pan-cancer analysis of genomic scar signatures associated with homologous recombination deficiency suggests novel indications for existing cancer drugs. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26040766&form=6&db=m PARP3 interacts with FoxM1 to confer glioblastoma cell radioresistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26047697&form=6&db=m The PARP1 inhibitor BMN 673 exhibits immunoregulatory effects in a Brca1(-/-) murine model of ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26050887&form=6&db=m Anti-tumor activity and the mechanism of SIP-S: A sulfated polysaccharide with anti-metastatic effect. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26053117&form=6&db=m Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26069190&form=6&db=m ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26069882&form=6&db=m Role of PARP-1 in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26073513&form=6&db=m PARG inhibitors and functional PARG inhibition models. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26080611&form=6&db=m The Role of PARP-1 in Host-Pathogen Interaction and Cellular Stress Responses. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26083025&form=6&db=m Prevalence of Germline Mutations in Genes Engaged in DNA Damage Repair by Homologous Recombination in Patients with Triple-Negative and Hereditary Non-Triple-Negative Breast Cancers. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26084306&form=6&db=m miR-223 reverses experimental pulmonary arterial hypertension. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26091340&form=6&db=m The Promise of Proteomics for the Study of ADP-Ribosylation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26091341&form=6&db=m Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26091343&form=6&db=m Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26097394&form=6&db=m PARP inhibitors and more. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26097871&form=6&db=m Drug conjugation to hyaluronan widens therapeutic indications for ovarian cancer. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26100884&form=6&db=m Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26112904&form=6&db=m Synergistic anticancer effects of combined ?-tocotrienol and oridonin treatment is associated with the induction of autophagy. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26124443&form=6&db=m Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26124641&form=6&db=m Combination of erlotinib and a PARP inhibitor inhibits growth of A2780 tumor xenografts due to increased autophagy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26132569&form=6&db=m Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26138335&form=6&db=m CTLA-4 Blockade Synergizes Therapeutically with PARP Inhibition in BRCA1-Deficient Ovarian Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26147240&form=6&db=m Discovery of New H2S Releasing Phosphordithioates and 2,3-Dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with Improved Antiproliferative Activity. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26148557&form=6&db=m Reorganization of metastamiRs in the evolution of metastatic aggressive neuroblastoma cells. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26169874&form=6&db=m PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26177331&form=6&db=m KIFC1 is a novel potential therapeutic target for breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26183824&form=6&db=m Poly(ADP-ribose) polymerase as a novel regulator of 17?-estradiol-induced cell growth through a control of the estrogen receptor/IGF-1 receptor/PDZK1 axis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26184161&form=6&db=m Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis. causal interaction,diagnostic usage,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26205198&form=6&db=m Structural Requirements of Some 2-(1-Propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide Derivatives as Poly (ADP-Ribose) Polymerase (PARP) for the Treatment of Cancer: QSAR Approach. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26211783&form=6&db=m Embracing synthetic lethality of novel anticancer therapies. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26212013&form=6&db=m Disrupting Na(+),HCO3(-)-cotransporter NBCn1 (Slc4a7) delays murine breast cancer development. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26215403&form=6&db=m Thymoquinone enhances cisplatin-response through direct tumor effects in a syngeneic mouse model of ovarian cancer. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26217019&form=6&db=m Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26218895&form=6&db=m Differentiation-Associated Downregulation of Poly(ADP-Ribose) Polymerase-1 Expression in Myoblasts Serves to Increase Their Resistance to Oxidative Stress. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26222319&form=6&db=m Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26242220&form=6&db=m Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26251615&form=6&db=m Profile of veliparib and its potential in the treatment of solid tumors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26253167&form=6&db=m M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26258074&form=6&db=m Sustained Complete Response to Cytotoxic Therapy and the PARP Inhibitor Veliparib in Metastatic Castration-Resistant Prostate Cancer - A Case Report. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26258887&form=6&db=m PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26263002&form=6&db=m Parasporin-2 from a New Bacillus thuringiensis 4R2 Strain Induces Caspases Activation and Apoptosis in Human Cancer Cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26268938&form=6&db=m PARP inhibitors in the management of breast cancer: current data and future prospects. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26281686&form=6&db=m [Cancer therapy by PARP inhibitors]. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26284809&form=6&db=m Induction of Apoptosis and Reduction of Endogenous Glutathione Level by the Ethyl-Acetate Soluble Fraction of the Methanol Extract of the Roots of Potentilla fulgens in Cancer Cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26296891&form=6&db=m Rapid fine conformational epitope mapping using comprehensive mutagenesis and deep sequencing. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26309417&form=6&db=m Olaparib in the management of ovarian cancer. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26310369&form=6&db=m Expression of DNA Damage Response Molecules PARP1, ?H2AX, BRCA1, and BRCA2 Predicts Poor Survival of Breast Carcinoma Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26312527&form=6&db=m Replication-induced DNA damage after PARP inhibition causes G2 delay, and cell line-dependent apoptosis, necrosis and multinucleation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26314963&form=6&db=m Inhibition of poly(ADP-ribose) polymerase 1 protects against acute myeloid leukemia by suppressing the myeloproliferative leukemia virus oncogene. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26317927&form=6&db=m Genomic hallmarks of homologous recombination deficiency in invasive breast carcinomas. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26336991&form=6&db=m DNA double strand break repair defect and sensitivity to poly ADP-ribose polymerase (PARP) inhibition in human papillomavirus 16-positive head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26339143&form=6&db=m The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26350251&form=6&db=m Curcumin enhances poly(ADP-ribose) polymerase inhibitor sensitivity to chemotherapy in breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26352770&form=6&db=m PARP inhibitors in ovarian and other cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26354718&form=6&db=m Chemotherapy reduces PARP1 in cancers of the ovary: implications for future clinical trials involving PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26374559&form=6&db=m Clinical Trials of Poly(ADP-Ribose) Polymerase Inhibitors for Cancer Therapy: A Review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26383629&form=6&db=m Sulfur and nitrogen mustards induce characteristic poly(ADP-ribosyl)ation responses in HaCaT keratinocytes with distinctive cellular consequences. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26383632&form=6&db=m Immunochemical analysis of poly(ADP-ribosyl)ation in HaCaT keratinocytes induced by the mono-alkylating agent 2-chloroethyl ethyl sulfide (CEES): Impact of experimental conditions. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26384693&form=6&db=m [From poly(ADP-ribose) discovery to PARP inhibitors in cancer therapy]. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26386190&form=6&db=m HPW-RX40 restores anoikis sensitivity of human breast cancer cells by inhibiting integrin/FAK signaling. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26395808&form=6&db=m BRCA1 and BARD1 colocalize mainly in the cytoplasm of breast cancer tumors, and their isoforms show differential expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26398108&form=6&db=m Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26399274&form=6&db=m Effectiveness and safety of poly (ADP-ribose) polymerase inhibitors in cancer therapy: A systematic review and meta-analysis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26403354&form=6&db=m 2D and 3D similarity landscape analysis identifies PARP as a novel off-target for the drug Vatalanib. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26422786&form=6&db=m Discovery and SAR study of 2-(1-propylpiperidin-4-yl)-3H-imidazo[4,5-c]pyridine-7-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) for the treatment of cancer. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26446488&form=6&db=m LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26448277&form=6&db=m Enhancement of Cytotoxicity and Inhibition of Angiogenesis in Oral Cancer Stem Cells by a Hybrid Nanoparticle of Bioactive Quinacrine and Silver: Implication of Base Excision Repair Cascade. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26469301&form=6&db=m Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP-ribose) Polymerase-1 (PARP-1) in Vivo. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26469962&form=6&db=m Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26483957&form=6&db=m PARP1 Inhibitors: antitumor drug design. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26485111&form=6&db=m Advances in PARP inhibitors for the treatment of breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26486165&form=6&db=m Ifosfamide-loaded poly (lactic-co-glycolic acid) PLGA-dextran polymeric nanoparticles to improve the antitumor efficacy in Osteosarcoma. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26492236&form=6&db=m PARP Inhibitor PJ34 Suppresses Osteogenic Differentiation in Mouse Mesenchymal Stem Cells by Modulating BMP-2 Signaling Pathway. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26497583&form=6&db=m Small PARP inhibitor PJ-34 induces cell cycle arrest and apoptosis of adult T-cell leukemia cells. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26505995&form=6&db=m Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26507796&form=6&db=m Targeting DNA repair, DNA metabolism and replication stress as anti-cancer strategies. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26510020&form=6&db=m DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26510816&form=6&db=m Suppression of Homologous Recombination by insulin-like growth factor-1 inhibition sensitizes cancer cells to PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26518726&form=6&db=m Sirtuins are Unaffected by PARP Inhibitors Containing Planar Nicotinamide Bioisosteres. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26518896&form=6&db=m PARP inhibition: A promising therapeutic target in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26528434&form=6&db=m Successes and Challenges of PARP Inhibitors in Cancer Therapy. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26530780&form=6&db=m Adenovirus-mediated p53 and ING4 gene co?transfer elicits synergistic antitumor effects through enhancement of p53 acetylation in breast cancer. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26540566&form=6&db=m Tumor suppressive effect of PARP1 and FOXO3A in gastric cancers and its clinical implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26546619&form=6&db=m mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26555243&form=6&db=m Novel ?-Carboline/Hydroxamic Acid Hybrids Targeting Both Histone Deacetylase and DNA Display High Anticancer Activity via Regulation of the p53 Signaling Pathway. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26561007&form=6&db=m Black Tea: Phytochemicals, Cancer Chemoprevention and Clinical Studies. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26562473&form=6&db=m Sonodynamic treatment as an innovative bimodal anticancer approach: shock wave-mediated tumor growth inhibition in a syngeneic breast cancer model. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26577420&form=6&db=m Expression of potential biomarkers associated with homologous recombination repair in patients with ovarian or triple-negative breast cancer. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26590714&form=6&db=m Targeting the DNA Damage Response in Cancer. causal interaction,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26590805&form=6&db=m A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26590990&form=6&db=m A novelly synthesized phenanthroline derivative is a promising DNA-damaging anticancer agent inhibiting G1/S checkpoint transition and inducing cell apoptosis in cancer cells. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26592508&form=6&db=m Anticancer bioactive peptides suppress human colorectal tumor cell growth and induce apoptosis via modulating the PARP-p53-Mcl-1 signaling pathway. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26608647&form=6&db=m Gonadotropin-mediated chemoresistance: Delineation of molecular pathways and targets. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26619102&form=6&db=m PARP-1 expression in CD34+ leukemic cells in childhood acute lymphoblastic leukemia: relation to response to initial therapy and other prognostic factors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26626479&form=6&db=m Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26650448&form=6&db=m Poly (ADP) ribose polymerase inhibition: A potential treatment of malignant peripheral nerve sheath tumor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26658963&form=6&db=m Olaparib Targets Some Advanced Prostate Cancers. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26679694&form=6&db=m Survivin contributes to DNA repair by homologous recombination in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26683770&form=6&db=m Deoxypodophyllotoxin triggers parthanatos in glioma cells via induction of excessive ROS. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26700152&form=6&db=m Reduced tumor burden through increased oxidative stress in lung adenocarcinoma cells of PARP-1 and PARP-2 knockout mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26707801&form=6&db=m Ceramide 1-phosphate regulates cell migration and invasion of human pancreatic cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26709647&form=6&db=m Critical role for BRCA1 expression as a marker of chemosensitivity response and prognosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26709902&form=6&db=m Alternative mechanisms of inhibiting activity of poly (ADP-ribose) polymerase-1. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26713604&form=6&db=m Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26748828&form=6&db=m Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26774285&form=6&db=m HELB Is a Feedback Inhibitor of DNA End Resection. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26779812&form=6&db=m Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26785283&form=6&db=m Ovarian cancer treatment in mutation carriers/brcaness. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26786262&form=6&db=m Phase II Study of Olaparib (AZD-2281) After Standard Systemic Therapies for Disseminated Colorectal Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26796987&form=6&db=m An open-label, dose-escalation study to evaluate the safety and pharmacokinetics of CEP-9722 (a PARP-1 and PARP-2 inhibitor) in combination with gemcitabine and cisplatin in patients with advanced solid tumors. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26799421&form=6&db=m PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response. causal interaction,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26799758&form=6&db=m Breast cancer in BRCA mutation carriers: medical treatment. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26807493&form=6&db=m Veliparib for the treatment of ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26817684&form=6&db=m Cytotoxic and apoptotic effects of heat killed Mycobacterium indicus pranii (MIP) on various human cancer cell lines. diagnostic usage,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26821867&form=6&db=m Tumor Suppression by PARP Inhibitors Is Potentiated by c-MET Inhibition. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26842236&form=6&db=m Phase I safety, pharmacokinetic and pharmacodynamic study of the poly (ADP-ribose) polymerase inhibitor veliparib with irinotecan in patients with advanced solid tumors. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26848151&form=6&db=m Veliparib Alone or in Combination with Mitomycin C in Patients with Solid Tumors With Functional Deficiency in Homologous Recombination Repair. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26851505&form=6&db=m 5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26881472&form=6&db=m Genomic instability in pancreatic adenocarcinoma: a new step towards precision medicine and novel therapeutic approaches. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26887755&form=6&db=m Re: Expression of Nuclear Matrix Proteins Binding Matrix Attachment Regions in Prostate Cancer. PARP-1: New Player in Tumor Progression. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26898760&form=6&db=m PARP1 enhances lung adenocarcinoma metastasis by novel mechanisms independent of DNA repair. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26900125&form=6&db=m Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26905326&form=6&db=m Poly(ADP-Ribose) Polymerase in Cervical Cancer Pathogenesis: Mechanism and Potential Role for PARP Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26905328&form=6&db=m Phosphatase and Tensin Homolog Is a Potential Target for Ovarian Cancer Sensitization to Cytotoxic Agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26907257&form=6&db=m In Silico Screening Identifies a Novel Potential PARP1 Inhibitor Targeting Synthetic Lethality in Cancer Treatment. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26916217&form=6&db=m Hyper-active non-homologous end joining selects for synthetic lethality resistant and pathological Fanconi anemia hematopoietic stem and progenitor cells. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26920250&form=6&db=m Poly (ADP-ribose) polymerases inhibitor, Zj6413, as a potential therapeutic agent against breast cancer. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26927065&form=6&db=m Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26931795&form=6&db=m New Targeted Agents in Gynecologic Cancers: Synthetic Lethality, Homologous Recombination Deficiency, and PARP Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26934368&form=6&db=m Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26934445&form=6&db=m ER maleate is a novel anticancer agent in oral cancer: Implications for cancer therapy. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26937492&form=6&db=m Olaparib for the treatment of ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26941449&form=6&db=m PARP Inhibitors for Recurrent Ovarian Carcinoma: Current Treatment Options and Future Perspectives. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26942084&form=6&db=m Enhancing tumor-targeting monoclonal antibodies therapy by PARP inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26950694&form=6&db=m A New Nanobody-Based Biosensor to Study Endogenous PARP1 In Vitro and in Live Human Cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26959114&form=6&db=m Reciprocal positive selection for weakness - preventing olaparib resistance by inhibiting BRCA2. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26967246&form=6&db=m The clinical value of aberrant epigenetic changes of DNA damage repair genes in human cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26969680&form=6&db=m Free energy calculation provides insight into the action mechanism of selective PARP-1 inhibitor. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26979391&form=6&db=m Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26979459&form=6&db=m Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26985304&form=6&db=m Potential Use of Inhibitors of Tankyrases and PARP-1 as Treatment for Cancer and Other Diseases. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26985944&form=6&db=m Paclitaxel induces apoptosis in leukemia cells through a JNK activation-dependent pathway. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26987799&form=6&db=m DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26997874&form=6&db=m Role of Biomarkers in the Development of PARP Inhibitors. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27002766&form=6&db=m PARP1 is a novel independent prognostic factor for the poor prognosis of chordoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27015684&form=6&db=m Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27022037&form=6&db=m Clinical Application of Poly(ADP-Ribose) Polymerase Inhibitors in High-Grade Serous Ovarian Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27023566&form=6&db=m A Selenium Containing Inhibitor for the Treatment of Hepatocellular Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27053772&form=6&db=m Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27055253&form=6&db=m Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27065456&form=6&db=m Homologous recombination deficiency and ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27068743&form=6&db=m The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the ?-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27069769&form=6&db=m [(18)F]FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27070314&form=6&db=m Cycloart-24-ene-26-ol-3-one, a New Cycloartane Isolated from Leaves of Aglaia exima Triggers Tumour Necrosis Factor-Receptor 1-Mediated Caspase-Dependent Apoptosis in Colon Cancer Cell Line. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27077006&form=6&db=m Effects of poly (ADP-ribose) polymerase-1 (PARP-1) inhibition on sulfur mustard-induced cutaneous injuries in vitro and in vivo. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27127105&form=6&db=m PARP Inhibitors in Epithelial Ovarian Cancer: State of Art and Perspectives of Clinical Research. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27128213&form=6&db=m PARP activity in peripheral blood lymphocytes as a predictive biomarker for PARP inhibition in tumor tissues - A population pharmacokinetic/pharmacodynamic analysis of rucaparib. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27141062&form=6&db=m Progress in the treatment of ovarian cancer-lessons from homologous recombination deficiency-the first 10 years. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27145275&form=6&db=m Non-thermal plasma-induced apoptosis is modulated by ATR- and PARP1-mediated DNA damage responses and circadian clock. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27148483&form=6&db=m Editorial: Inhibiting PARP as a Strategic Target in Cancer. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27149849&form=6&db=m PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27155850&form=6&db=m Assessment of PARP protein expression in epithelial ovarian cancer by ELISA pharmacodynamic assay and immunohistochemistry. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27163403&form=6&db=m PEGylated lipid bilayer-supported mesoporous silica nanoparticle composite for synergistic co-delivery of axitinib and celastrol in multi-targeted cancer therapy. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27168003&form=6&db=m PARP inhibition and gynecologic malignancies: A review of current literature and on-going trials. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27169997&form=6&db=m Molecular Pathways: Targeting DNA Repair Pathway Defects Enriched in Metastasis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27188668&form=6&db=m Targeting PARP in Prostate Cancer: Novelty, Pitfalls, and Promise. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27196668&form=6&db=m Overcoming Resistance of Cancer Cells to PARP-1 Inhibitors with Three Different Drug Combinations. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27226207&form=6&db=m Evaluation of the methods to identify patients who may benefit from PARP inhibitor use. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27233451&form=6&db=m Biphasic reduction of histone H3 phosphorylation in response to N-nitroso compounds induced DNA damage. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27241520&form=6&db=m Genomic Characterization of High-Grade Serous Ovarian Cancer: Dissecting Its Molecular Heterogeneity as a Road Towards Effective Therapeutic Strategies. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27249731&form=6&db=m Gynecologic Cancers: Emerging Novel Strategies for Targeting DNA Repair Deficiency. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27256873&form=6&db=m Patient Counseling and Management of Symptoms During Olaparib Therapy for Recurrent Ovarian Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27261505&form=6&db=m A Radiotracer Strategy to Quantify PARP-1 Expression In Vivo Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27282964&form=6&db=m Preclinical evaluation of olaparib and metformin combination in BRCA1 wildtype ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27308587&form=6&db=m Trial watch - inhibiting PARP enzymes for anticancer therapy. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27315035&form=6&db=m Virtual screening of small molecules databases for discovery of novel PARP-1 inhibitors: combination of in silico and in vitro studies. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27317574&form=6&db=m DNA Repair Deficiency Is Common in Advanced Prostate Cancer: New Therapeutic Opportunities. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27318679&form=6&db=m DNA Repair. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27323894&form=6&db=m Base excision repair pathway: PARP1 genotypes as modulators of therapy response in cervical cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27334689&form=6&db=m ABT-888 and quinacrine induced apoptosis in metastatic breast cancer stem cells by inhibiting base excision repair via adenomatous polyposis coli. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27335087&form=6&db=m Fuzheng Qingjie Granules Inhibit Growth of Hepatoma Cells via Inducing Mitochondria-Mediated Apoptosis and Enhancing Immune Function. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27336789&form=6&db=m Registered report: Systematic identification of genomic markers of drug sensitivity in cancer cells. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27353254&form=6&db=m Anti-tumor effect of ?-glucan from Lentinus edodes and the underlying mechanism. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27353531&form=6&db=m Design, synthesis and biological evaluation of novel 5-fluoro-1H-benzimidazole-4-carboxamide derivatives as potent PARP-1 inhibitors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27362900&form=6&db=m The Prognostic Value of BRCA1 and PARP Expression in Epithelial Ovarian Carcinoma: Immunohistochemical Detection. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27367669&form=6&db=m A Homogeneous Polysaccharide from Fructus Schisandra chinensis (Turz.) Baill Induces Mitochondrial Apoptosis through the Hsp90/AKT Signalling Pathway in HepG2 Cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27368114&form=6&db=m DNA Damage Repair and the Emerging Role of Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapeutics. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27375368&form=6&db=m PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27376578&form=6&db=m p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27381626&form=6&db=m Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27385001&form=6&db=m miR-151-5p, targeting chromatin remodeler SMARCA5, as a marker for the BRCAness phenotype. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27402769&form=6&db=m Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27409836&form=6&db=m Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27412498&form=6&db=m Biological characterization of bovine mammary epithelial cell lines immortalized by HPV16 E6/E7 and SV40T. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27416328&form=6&db=m An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27422301&form=6&db=m Safety and tolerability of the olaparib tablet formulation in Japanese patients with advanced solid tumours. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27424423&form=6&db=m [BRCA mutations: from Angelina Jolie to specific therapies]. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27425251&form=6&db=m Radiosensitization by PARP inhibition to proton beam irradiation in cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27425647&form=6&db=m Tankyrase as a Novel Molecular Target in Cancer and Fibrotic Diseases. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27426307&form=6&db=m Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27427773&form=6&db=m The PARP inhibitor PJ-34 sensitizes cells to UVA-induced phototoxicity by a PARP independent mechanism. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27428646&form=6&db=m PARP Inhibitors in Clinical Use Induce Genomic Instability in Normal Human Cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27440880&form=6&db=m Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27443740&form=6&db=m Replication fork stability confers chemoresistance in BRCA-deficient cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27444036&form=6&db=m Panobinostat sensitizes cyclin E high, homologous recombination-proficient ovarian cancer to olaparib. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27448916&form=6&db=m New (E)-1-alkyl-1H-benzo[d]imidazol-2-yl)methylene)indolin-2-ones: Synthesis, in vitro cytotoxicity evaluation and apoptosis inducing studies. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27452924&form=6&db=m In Vivo therapeutic potential of mesenchymal stem cell-derived extracellular vesicles with optical imaging reporter in tumor mice model. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27453990&form=6&db=m Isolation, Characterization and Anticancer Potential of Cytotoxic Triterpenes from Betula utilis Bark. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27454287&form=6&db=m BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27454289&form=6&db=m RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27455135&form=6&db=m DNA damage response as a therapeutic target in gynecological cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27466483&form=6&db=m Efficacy of the Combination of a PARP Inhibitor and UVC on Cancer Cells as Imaged by Focus Formation by the DNA Repair-related Protein 53BP1 Linked to Green Fluorescent Protein. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27476430&form=6&db=m Inactivation of hypoxia-induced YAP by statins overcomes hypoxic resistance tosorafenib in hepatocellular carcinoma cells. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27487106&form=6&db=m The status of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors in ovarian cancer, part 1: olaparib. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27494558&form=6&db=m Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-?-Catenin Signaling. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27503931&form=6&db=m Inhibiting Mitochondrial DNA Ligase III? Activates Caspase 1-Dependent Apoptosis in Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27530326&form=6&db=m CRISPR/Cas9-mediated Trp53 and Brca2 knockout to generate improved murine models of ovarian high grade serous carcinoma. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27533253&form=6&db=m Simultaneous detection of BRCA mutations and large genomic rearrangements in germline DNA and FFPE tumor samples. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27548061&form=6&db=m Correction: Overcoming Resistance of Cancer Cells to PARP-1 Inhibitors with Three Different Drug Combinations. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27550455&form=6&db=m The PARP inhibitor AZD2461 provides insights into the role of PARP3 inhibition for both synthetic lethality and tolerability with chemotherapy in preclinical models. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27550963&form=6&db=m Defects in HR repair behind the human diseases: FA and HBOC. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27551000&form=6&db=m A Phase I study of topotecan, carboplatin and the PARP inhibitor veliparib in acute leukemias, aggressive myeloproliferative neoplasms and chronic myelomonocytic leukemia. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27555886&form=6&db=m Cytotoxic and targeted therapy for hereditary cancers. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27558151&form=6&db=m Ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27559053&form=6&db=m Drug Driven Synthetic Lethality: bypassing tumor cell genetics with a combination of Dbait and PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27565811&form=6&db=m Beet root juice protects against doxorubicin toxicity in cardiomyocytes while enhancing apoptosis in breast cancer cells. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27572101&form=6&db=m Casticin induces DNA damage and inhibits DNA repair-associated protein expression in B16F10 mouse melanoma cancer cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27579892&form=6&db=m PARP3 controls TGF? and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27588595&form=6&db=m Tumor Cell Recovery from Senescence Induced by Radiation with PARP Inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27590317&form=6&db=m DNA Repair in Prostate Cancer: Biology and Clinical Implications. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27596623&form=6&db=m Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27610459&form=6&db=m Genetic Association of PARP15 Polymorphisms with Clinical Outcome of Acute Myeloid Leukemia in a Korean Population. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27613321&form=6&db=m Cytotoxicity and genotoxicity induced in vitro by solvent-extractable organic matter of size-segregated urban particulate matter. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27613518&form=6&db=m 53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27634150&form=6&db=m Update on Poly-ADP-ribose polymerase inhibition for ovarian cancer treatment. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27642590&form=6&db=m Predictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized Medicine. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27643881&form=6&db=m Individual and Combined Expression of DNA Damage Response Molecules PARP1, ?H2AX, BRCA1, and BRCA2 Predict Shorter Survival of Soft Tissue Sarcoma Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27644669&form=6&db=m Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27651058&form=6&db=m [The clonal evolution of osteosarcomas]. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27655641&form=6&db=m Uncovering synthetic lethal interactions for therapeutic targets and predictive markers in lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27659937&form=6&db=m PARP-1 depletion in combination with carbon ion exposure significantly reduces MMPs activity and overall increases TIMPs expression in cultured HeLa cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27663481&form=6&db=m Pharmacodynamic analyses in a multi-laboratory network: lessons from the poly(ADP-ribose) assay. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27671334&form=6&db=m AXL Inhibition Suppresses the DNA Damage Response and Sensitizes Cells to PARP Inhibition in Multiple Cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27673289&form=6&db=m The status of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors in ovarian cancer, part 2: extending the scope beyond olaparib and BRCA1/2 mutations. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27689533&form=6&db=m Iodinated benzimidazole PARP radiotracer for evaluating PARP1/2 expression in vitro and in vivo. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27705909&form=6&db=m PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27705915&form=6&db=m LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27708213&form=6&db=m Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27716527&form=6&db=m Nanomedicine-based paclitaxel induced apoptotic signaling pathways in A562 leukemia cancer cells. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27716873&form=6&db=m The current status of PARP inhibitors in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27725894&form=6&db=m Understanding specific functions of PARP-2: new lessons for cancer therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27726394&form=6&db=m Stereoisomers of Astaxanthin Inhibit Human Colon Cancer Cell Growth by Inducing G2/M Cell Cycle Arrest and Apoptosis. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27727003&form=6&db=m Non-NAD-Like poly(ADP-Ribose) Polymerase-1 Inhibitors effectively Eliminate Cancer in vivo. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27728808&form=6&db=m Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27736844&form=6&db=m PARP inhibitors for BRCA1/2-mutated and sporadic ovarian cancer: current practice and future directions. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27739325&form=6&db=m A randomized Phase II study of veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in BRCA1/2 metastatic breast cancer: design and rationale. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27740936&form=6&db=m Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27742744&form=6&db=m A novel L-fucose-binding lectin from Fenneropenaeus indicus induced cytotoxicity in breast cancer cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27746584&form=6&db=m The Effect of Poly(ADP-ribose) Polymerase-1 Gene 3'Untranslated Region Polymorphism in Colorectal Cancer Risk among Saudi Cohort. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27749330&form=6&db=m Targeting DNA Repair: The Role of PARP Inhibition in the Treatment of Castration-Resistant Prostate Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27756336&form=6&db=m Identification of BRCA1-like triple-negative breast cancers by quantitative multiplex-ligation-dependent probe amplification (MLPA) analysis of BRCA1-associated chromosomal regions: a validation study. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27760931&form=6&db=m [The Role of Preoperative Chemotherapy Depending on Breast Cancer Subtype]. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27767231&form=6&db=m Novel BRCA1 and BRCA2 Tumor Test as Basis for Treatment Decisions and Referral for Genetic Counselling of Patients with Ovarian Carcinomas. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27797957&form=6&db=m Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27811014&form=6&db=m Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27811964&form=6&db=m The Poly (ADP-Ribose) Polymerase Inhibitor Veliparib and Radiation Cause Significant Cell Line Dependent Metabolic Changes in Breast Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27817742&form=6&db=m PARG Inhibitors and Functional PARG Inhibition Models. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27821802&form=6&db=m Role of DNA repair machinery and p53 in the testicular germ cell cancer: a review. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27841036&form=6&db=m PARP inhibitors as antitumor agents: a patent update (2013-2015). causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27841728&form=6&db=m PET of Poly (ADP-Ribose) Polymerase Activity in Cancer: Preclinical Assessment and First In-Human Studies. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27846720&form=6&db=m [Molecular Mechanisms of Carcinogenesis of Epithelial Ovarian Cancers]. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27863496&form=6&db=m Evaluation of anti-tumorigenic activity of BP3B against colon cancer with patient-derived tumor xenograft model. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27866910&form=6&db=m Proteome-wide Profiling of Clinical PARP Inhibitors Reveals Compound-Specific Secondary Targets. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27869444&form=6&db=m [BRCA1 and BRCA2 - pathologists starting kit]. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27869447&form=6&db=m [Testing of mutations in BRCA1 and BRCA2 genes in tumor tissues - possibilities and limitations]. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27869910&form=6&db=m The methanol-ethyl acetate partitioned fraction from Chinese olive fruits inhibits cancer cell proliferation and tumor growth by promoting apoptosis through the suppression of the NF-?B signaling pathway. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27880910&form=6&db=m CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27884198&form=6&db=m Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27894958&form=6&db=m Poly (ADP-ribose) polymerase inhibitors selectively induce cytotoxicity in TCF3-HLF-positive leukemic cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27895737&form=6&db=m High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27898364&form=6&db=m Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27908594&form=6&db=m Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27918638&form=6&db=m Small Molecule Microarray Based Discovery of PARP14 Inhibitors. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27926532&form=6&db=m Novel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27928024&form=6&db=m Erratum for the Perspective: "Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action" by Y. Pommier, M. J. O'Connor, J. de Bono. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27931843&form=6&db=m PARP inhibitor combination therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27935989&form=6&db=m BRCAness and Prognosis in Triple-Negative Breast Cancer Patients Treated with Neoadjuvant Chemotherapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27943283&form=6&db=m Prophylactic window therapy with the clinical poly(ADP-ribose) polymerase inhibitor olaparib delays BRCA1-deficient mammary tumour formation in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27958296&form=6&db=m Gynaecological cancer: PARP inhibition - moving beyond BRCA-mutated disease. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27960087&form=6&db=m Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27978798&form=6&db=m Combination Platinum-based and DNA Damage Response-targeting Cancer Therapy: Evolution and Future Directions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27984176&form=6&db=m PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27993965&form=6&db=m Targeting the ATR/CHK1 axis with PARP inhibition results in tumor regression in BRCA mutant ovarian cancer models. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27994514&form=6&db=m The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27995810&form=6&db=m A comprehensive look of poly(ADP-ribose) polymerase inhibition strategies and future directions for cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27997688&form=6&db=m Novel splice-switching oligonucleotide promotes BRCA1 aberrant splicing and susceptibility to PARP inhibitor action. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28002809&form=6&db=m Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of ovarian clear cell cancer. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28003142&form=6&db=m Design, synthesis and biological activity of novel molecules designed to target PARP and DNA. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28003236&form=6&db=m Targeting DNA Repair in Cancer: Beyond PARP Inhibitors. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28004814&form=6&db=m Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28013023&form=6&db=m Metabolic roles of poly(ADP-ribose) polymerases. diagnostic usage,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28033382&form=6&db=m Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28034751&form=6&db=m MLN4924 suppresses the BRCA1 complex and synergizes with PARP inhibition in NSCLC cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28034904&form=6&db=m RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28057663&form=6&db=m PARP inhibitor and chemotherapy combination trials for the treatment of advanced malignancies: does a development pathway forward exist? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28078645&form=6&db=m PARP Inhibitors in Reproductive System Cancers: Current Use and Developments. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28086241&form=6&db=m LncRNA-SLC6A9-5:2: A potent sensitizer in 131I-resistant papillary thyroid carcinoma with PARP-1 induction. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28087320&form=6&db=m Poly(ADP-ribose) polymerase activity and inhibition in cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28101214&form=6&db=m PARP-1 may be involved in angiogenesis in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28111726&form=6&db=m Ganetespib overcomes resistance to PARP inhibitors in breast cancer by targeting core proteins in the DNA repair machinery. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28120709&form=6&db=m DNA-Damaging Anticancer Drugs - a Perspective for DNA Repair-Oriented Therapy. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28123587&form=6&db=m Analysis of molecular markers as predictive factors of lymph node involvement in breast carcinoma. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28124401&form=6&db=m BRCA1 alterations with additional defects in DNA damage response genes may confer chemoresistance to BRCA-like breast cancers treated with neoadjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28131528&form=6&db=m Expression of DNA damage response proteins in cervical cancer patients treated with radical chemoradiotherapy. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28138868&form=6&db=m Combination treatment using DDX3 and PARP inhibitors induces synthetic lethality in BRCA1-proficient breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28146604&form=6&db=m The clinically used PARP inhibitor olaparib improves organ function, suppresses inflammatory responses and accelerates wound healing in a murine model of third-degree burn injury. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28148839&form=6&db=m 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28150212&form=6&db=m Generation of Dose-Response Curves and Improved IC50s for PARP Inhibitor Nanoformulations. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28152151&form=6&db=m Population-Attributable Risk Proportion of Clinical Risk Factors for Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,1,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28162271&form=6&db=m Nitric Oxide: Genomic Instability And Synthetic Lethality. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28167507&form=6&db=m PARP inhibitor upregulates PD-L1 expression and enhances cancer-associated immunosuppression. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28169543&form=6&db=m Novel ent-Kaurane Diterpenoid from Rubus corchorifolius L. f. Inhibits Human Colon Cancer Cell Growth via Inducing Cell Cycle Arrest and Apoptosis. causal interaction,diagnostic usage,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28176879&form=6&db=m PARP inhibitor increases chemosensitivity by upregulating miR-664b-5p in BRCA1-mutated triple-negative breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28182794&form=6&db=m Identification of several high-risk HPV inhibitors and drug targets with a novel high-throughput screening assay. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28205193&form=6&db=m New Therapeutic Strategies for Triple-Negative Breast Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28207569&form=6&db=m Poly ADP-ribose polymerase inhibition suppresses cisplatin toxicity in chronic myeloid leukemia cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28211356&form=6&db=m Correction: Synergistic Activity of PARP Inhibition by Talazoparib (BMN 673) with Temozolomide in Pediatric Cancer Models in the Pediatric Preclinical Testing Program. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28211448&form=6&db=m CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28212373&form=6&db=m Poly (ADP-ribose) polymerase 1 mRNA levels strongly correlate with the prognosis of myelodysplastic syndromes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28212569&form=6&db=m MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28216025&form=6&db=m PI3K-AKT-mTOR inhibitors in breast cancers: From tumor cell signaling to clinical trials. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28221868&form=6&db=m Somatic BRCA1/2 Recovery as a Resistance Mechanism After Exceptional Response to Poly (ADP-ribose) Polymerase Inhibition. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28222073&form=6&db=m A phase I study of intravenous and oral rucaparib in combination with chemotherapy in patients with advanced solid tumours. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28241425&form=6&db=m Heat Shock Factor 1 Depletion Sensitizes A172 Glioblastoma Cells to Temozolomide via Suppression of Cancer Stem Cell-Like Properties. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28242626&form=6&db=m ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28242752&form=6&db=m Phase I, Dose-Escalation, 2-Part Trial of Poly(ADP-Ribose) Polymerase Inhibitor Talazoparib in Patients with Advanced Germline BRCA1/2 Mutations and Selected Sporadic Cancers. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28247266&form=6&db=m Rucaparib: First Global Approval. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28250726&form=6&db=m PARP inhibitors: review of mechanisms of action and BRCA1/2 mutation targeting. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28254358&form=6&db=m Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28255272&form=6&db=m Reverse the Resistance to PARP Inhibitors. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28258387&form=6&db=m [BRCA diagnostics of ovarian cancer : Molecular tumor testing since the introduction of PARP inhibitor therapy]. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28264872&form=6&db=m A Phase I-II Study of the Oral Poly(ADP-ribose) Polymerase Inhibitor Rucaparib in Patients with Germline BRCA1/2-mutated Ovarian Carcinoma or Other Solid Tumors. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28273485&form=6&db=m Clinical factors of response in patients with advanced ovarian cancer participating in early phase clinical trials. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28280302&form=6&db=m Defective DNA repair mechanisms in prostate cancer: impact of olaparib. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28288110&form=6&db=m HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28291774&form=6&db=m BRCA2 secondary mutation-mediated resistance to platinum and PARP inhibitor-based therapy in pancreatic cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28302009&form=6&db=m Expression and Single Nucleotide Polymorphism of Poly (ADPRibose) Polymerase-1 in Gastrointestinal Tumours: Clinical Involvement. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28302823&form=6&db=m PARP inhibitors: Synthetic lethality in the clinic. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28314386&form=6&db=m Veliparib in combination with radiotherapy for the treatment of MGMT unmethylated glioblastoma. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28315326&form=6&db=m Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28322442&form=6&db=m Systems analysis of dynamic transcription factor activity identifies targets for treatment in olaparib resistant cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28323334&form=6&db=m The emerging role of homologous recombination repair and PARP inhibitors in genitourinary malignancies. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28336669&form=6&db=m A conserved NAD(+) binding pocket that regulates protein-protein interactions during aging. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28340968&form=6&db=m Genetics of triple-negative breast cancer: Implications for patient care. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28347815&form=6&db=m Sigma-2 ligands and PARP inhibitors synergistically trigger cell death in breast cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28356985&form=6&db=m Molecular mechanisms of cholangiocarcinoma cell inhibition by medicinal plants. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28363999&form=6&db=m ATM deficiency is associated with sensitivity to PARP1 and ATR inhibitors in lung adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28376211&form=6&db=m Rad51 Degradation: Role in Oncolytic Virus-Poly(ADP-Ribose) Polymerase Inhibitor Combination Therapy in Glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28381406&form=6&db=m Exploiting Defective DNA Repair in IDH-Mutant Cancers. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28387939&form=6&db=m Parent-Metabolite Pharmacokinetic Modeling and Pharmacodynamics of Veliparib (ABT-888), a PARP Inhibitor, in Patients With BRCA 1/2-Mutated Cancer or PARP-Sensitive Tumor Types. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28388401&form=6&db=m PARP Inhibitors for Cancer Therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28394338&form=6&db=m PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28398198&form=6&db=m Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28404569&form=6&db=m Analysis Suggests Wider Use for PARP Inhibitors. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28407749&form=6&db=m Down-regulated expression of OPCML predicts an unfavorable prognosis and promotes disease progression in human gastric cancer. diagnostic usage,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28410123&form=6&db=m Poly(ADP-Ribose) polymerase 1: a therapeutic hope in gynecologic cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28412778&form=6&db=m PARP Inhibitors: The Cornerstone of DNA Repair-Targeted Therapies. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28414200&form=6&db=m Combining 53BP1 with BRCA1 as a biomarker to predict the sensitivity of poly(ADP-ribose) polymerase (PARP) inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28425306&form=6&db=m Therapeutic targeting and patient selection for cancers with homologous recombination defects. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28426671&form=6&db=m Effect of mitochondrially targeted carboxy proxyl nitroxide on Akt-mediated survival in Daudi cells: Significance of a dual mode of action. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28429680&form=6&db=m The Inhibitory Effects of HYDAMTIQ, a Novel PARP Inhibitor, on Growth in Human Tumor Cell Lines With Defective DNA Damage Response Pathways. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28445046&form=6&db=m Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454214&form=6&db=m Genome-wide analysis of gynecologic cancer: The Cancer Genome Atlas in ovarian and endometrial cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454476&form=6&db=m PARP inhibition sensitizes endometrial cancer cells to paclitaxel-induced apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454547&form=6&db=m PARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28456626&form=6&db=m Compound 21 and Telmisartan combination mitigates type 2 diabetic nephropathy through amelioration of caspase mediated apoptosis. diagnostic usage,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28457938&form=6&db=m PARP inhibition protects mitochondria and reduces ROS production via PARP-1-ATF4-MKP-1-MAPK retrograde pathway. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28462496&form=6&db=m Synthetic lethal targeting of RNF20 through PARP1 silencing and inhibition. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28471727&form=6&db=m Safety and Clinical Activity of the Programmed Death-Ligand 1 Inhibitor Durvalumab in Combination With Poly (ADP-Ribose) Polymerase Inhibitor Olaparib or Vascular Endothelial Growth Factor Receptor 1-3 Inhibitor Cediranib in Women's Cancers: A Dose-Escalation, Phase I Study. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28474297&form=6&db=m Niraparib: First Global Approval. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28481984&form=6&db=m The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28482792&form=6&db=m Poly (ADP-Ribosyl) Polymerase 1 Inhibitors: A Patent Review. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28487110&form=6&db=m NF90 regulates PARP1 mRNA stability in hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28491146&form=6&db=m PARP inhibitors in ovarian cancer: evidence, experience and clinical potential. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28497258&form=6&db=m Clinical Pharmacokinetics and Mass Balance of Veliparib in Combination with Temozolomide in Subjects with Nonhematologic Malignancies. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28500233&form=6&db=m Nanoformulation of Olaparib Amplifies PARP Inhibition and Sensitizes PTEN/TP53-Deficient Prostate Cancer to Radiation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28502307&form=6&db=m [Knock-down of DAB2 interacting protein (DAB2IP) promotes proliferation and inhibits apoptosis of bladder cancer cells]. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28510338&form=6&db=m Therapeutic Targeting of Poly(ADP-Ribose) Polymerase-1 (PARP1) in Cancer: Current Developments, Therapeutic Strategies, and Future Opportunities. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28512243&form=6&db=m Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28521333&form=6&db=m Drugging the Cancers Addicted to DNA Repair. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28526868&form=6&db=m Chitosan-Dextran sulfate coated doxorubicin loaded PLGA-PVA-nanoparticles caused apoptosis in doxorubicin resistance breast cancer cells through induction of DNA damage. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28536297&form=6&db=m Androgen receptor inhibitor-induced "BRCAness" and PARP inhibition are synthetically lethal for castration-resistant prostate cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28539474&form=6&db=m A GEMA of a personalized medicine strategy. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28543772&form=6&db=m PARP inhibitor rucaparib induces changes in NAD levels in cells and liver tissues as assessed by MRS. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28551640&form=6&db=m vPARP Adjusts MVP Expression in Drug-resistant Cell Lines in Conjunction with MDR Proteins. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28560500&form=6&db=m Synergistic induction of apoptosis by combination treatment with mesupron and auranofin in human breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28561656&form=6&db=m Whence High-Grade Serous Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28566428&form=6&db=m Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28567017&form=6&db=m Azoxystrobin Induces Apoptosis of Human Esophageal Squamous Cell Carcinoma KYSE-150 Cells through Triggering of the Mitochondrial Pathway. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28572169&form=6&db=m Tumor-targeted Nanoparticle Delivery of HuR siRNA Inhibits Lung Tumor Growth In Vitro and In Vivo By Disrupting the Oncogenic Activity of the RNA-binding Protein HuR. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28582759&form=6&db=m ?-Mangostin inhibits DMBA/TPA-induced skin cancer through inhibiting inflammation and promoting autophagy and apoptosis by regulating PI3K/Akt/mTOR signaling pathway in mice. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28583748&form=6&db=m Development of PARP inhibitors in gynecological malignancies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28583909&form=6&db=m Olaparib Keeps Hereditary Breast Tumors in Check. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28588086&form=6&db=m Papers of note in Science Translational Medicine 9 (392). therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28598107&form=6&db=m [The Antitumor Effects of Fisetin on Ovarian Cancer in vitro and in vivo.] causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28599464&form=6&db=m DNA repair genes polymorphisms and genetic susceptibility to Philadelphia-negative myeloproliferative neoplasms in a Portuguese population: The role of base excision repair genes polymorphisms. diagnostic usage,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28600955&form=6&db=m PARP activity and inhibition in fetal and adult oligodendrocyte precursor cells: Effect on cell survival and differentiation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28601509&form=6&db=m Olaparib hydroxamic acid derivatives as dual PARP and HDAC inhibitors for cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28614779&form=6&db=m The effect of the nitroxide pirolin on oxidative stress induced by doxorubicin and taxanes in the rat brain. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28619759&form=6&db=m Modeling Therapy Resistance in BRCA1/2-Mutant Cancers. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28628639&form=6&db=m Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28628830&form=6&db=m Breviscapine (BVP) inhibits prostate cancer progression through damaging DNA by minichromosome maintenance protein-7 (MCM-7) modulation. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28629998&form=6&db=m Aloe-emodin (AE) nanoparticles suppresses proliferation and induces apoptosis in human lung squamous carcinoma via ROS generation in vitro and in vivo. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28634224&form=6&db=m IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28649435&form=6&db=m Improved prediction of PARP inhibitor response and identification of synergizing agents through use of a novel gene expression signature generation algorithm. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28654422&form=6&db=m PARP1 expression and its correlation with survival is tumour molecular subtype dependent in glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28662958&form=6&db=m Targeting ATR in cancer medicine. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28676700&form=6&db=m The multifaceted roles of PARP1 in DNA repair and chromatin remodelling. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28678836&form=6&db=m Epistasis in genomic and survival data of cancer patients. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28692916&form=6&db=m Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28695500&form=6&db=m Quantification of PARP Activity in Human Tissues: Ex Vivo Assays in Blood Cells and Immunohistochemistry in Human Biopsies. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28695503&form=6&db=m Cell Cycle Resolved Measurements of Poly(ADP-Ribose) Formation and DNA Damage Signaling by Quantitative Image-Based Cytometry. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28695506&form=6&db=m Using Clickable NAD(+) Analogs to Label Substrate Proteins of PARPs. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28695517&form=6&db=m High-Throughput Colorimetric Assay for Identifying PARP-1 Inhibitors Using a Large Small-Molecule Collection. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28695519&form=6&db=m In Vitro Long-Term Proliferation Assays to Study Antiproliferative Effects of PARP Inhibitors on Cancer Cells. ongoing research,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28695520&form=6&db=m Use of Inosine Monophosphate Dehydrogenase Activity Assay to Determine the Specificity of PARP-1 Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28695521&form=6&db=m The Use of PARP Inhibitors in Cancer Therapy: Use as Adjuvant with Chemotherapy or Radiotherapy, Use as a Single Agent in Susceptible Patients, and Techniques Used to Identify Susceptible Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28699513&form=6&db=m PARP Inhibitor Drugs In The Treatment Of Breast, Ovarian, Prostate And Pancreatic Cancers: An Update of Clinical Trials. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28711021&form=6&db=m Sensitizing effects of an organovanadium compound during adjuvant therapy with cyclophosphamide in a murine tumor model. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28713162&form=6&db=m ABT-263 induces G1/G0-phase arrest, apoptosis and autophagy in human esophageal cancer cells in vitro. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28714367&form=6&db=m PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28714471&form=6&db=m Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28718810&form=6&db=m DNA2-An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28726723&form=6&db=m Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-?B Signaling. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28729482&form=6&db=m BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28735897&form=6&db=m RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28745064&form=6&db=m Therapeutic potential of investigational CHK-1 inhibitors for the treatment of solid tumors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28747513&form=6&db=m Repression of BET activity sensitizes homologous recombination-proficient cancers to PARP inhibition. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28763368&form=6&db=m Veliparib Monotherapy to Patients With BRCA Germ Line Mutation and Platinum-Resistant or Partially Platinum-Sensitive Relapse of Epithelial Ovarian Cancer: A Phase I/II Study. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28763648&form=6&db=m Design, synthesis and biological evaluation of 4-amidobenzimidazole acridine derivatives as dual PARP and Topo inhibitors for cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28770827&form=6&db=m Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28789382&form=6&db=m Poly (ADP-ribose) polymerase-1 inhibition decreases proliferation through G2/M arrest in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28797568&form=6&db=m The combination of A-966492 and Topotecan for effective radiosensitization on glioblastoma spheroids. causal interaction,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28800469&form=6&db=m Immunotherapy in ovarian, endometrial and cervical cancer: State of the art and future perspectives. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28801308&form=6&db=m EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork-Associated DNA Damage Repair. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28802254&form=6&db=m TDP1 is critical for the repair of DNA breaks induced by sapacitabine, a nucleoside also targeting ATM- and BRCA-deficient tumors. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28823558&form=6&db=m Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28829366&form=6&db=m Understanding Resistance Mechanisms and Expanding the Therapeutic Utility of PARP Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28840549&form=6&db=m Approaches for Identifying Novel Targets in Precision Medicine: Lessons from DNA Repair. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28847819&form=6&db=m The role of ubiquitin-dependent segregase p97 (VCP or Cdc48) in chromatin dynamics after DNA double strand breaks. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28851423&form=6&db=m The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28851861&form=6&db=m Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28855578&form=6&db=m HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,2 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28856922&form=6&db=m Detection and Delineation of Oral Cancer With a PARP1-Targeted Optical Imaging Agent. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28864639&form=6&db=m Reversion Mutations with Clinical Use of PARP Inhibitors: Many Genes, Many Versions. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28868867&form=6&db=m [Apoptosis mechanism of taxol combined with resveratrol on human laryngeal carcinoma Hep-2 cells]. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28881569&form=6&db=m Aurora A kinase regulates non-homologous end-joining and poly(ADP-ribose) polymerase function in ovarian carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28886275&form=6&db=m Preclinical rationale for combination of crizotinib with mitomycin C for the treatment of advanced colorectal cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28887922&form=6&db=m Gramine inhibits angiogenesis and induces apoptosis via modulation of TGF-? signalling in 7,12 dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinoma. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28895177&form=6&db=m A Novel Use for Olaparib for Treatment of Metastatic Castration-Recurrent Prostate Cancer. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28899971&form=6&db=m Matrix screen identifies synergistic combination of PARP inhibitors and nicotinamide phosphoribosyltransferase (NAMPT) inhibitors in Ewing sarcoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28903334&form=6&db=m Base excision repair imbalance in colorectal cancer has prognostic value and modulates response to chemotherapy. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28916476&form=6&db=m Pharmacologic ascorbate induces neuroblastoma cell death by hydrogen peroxide mediated DNA damage and reduction in cancer cell glycolysis. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28916726&form=6&db=m The NQO1 bioactivatable drug, ?-Lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism. causal interaction,diagnostic usage,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28925391&form=6&db=m EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28930534&form=6&db=m Regulation of poly(ADP-Ribose) polymerase 1 functions by post-translational modifications. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28935426&form=6&db=m cis-[RuCl(BzCN) (bipy) (dppe)]PF6 induces anti-angiogenesis and apoptosis by a mechanism of caspase-dependent involving DNA damage, PARP activation, and Tp53 induction in Ehrlich tumor cells. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28938581&form=6&db=m Targeting progastrin enhances radiosensitization of colorectal cancer cells. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28945226&form=6&db=m PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28978184&form=6&db=m Poly-(ADP-ribose)-polymerase inhibitors as radiosensitizers: a systematic review of pre-clinical and clinical human studies. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28979099&form=6&db=m Investigating isoquinoline derivatives for inhibition of inhibitor of apoptosis proteins for ovarian cancer treatment. diagnostic usage,ongoing research,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28981112&form=6&db=m Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28985359&form=6&db=m PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28991194&form=6&db=m PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28993682&form=6&db=m Olaparib modulates DNA repair efficiency, sensitizes cervical cancer cells to cisplatin and exhibits anti-metastatic property. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28994564&form=6&db=m Targeted therapy for ovarian cancer: the rapidly evolving landscape of PARP inhibitor use. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29016221&form=6&db=m Apoptotic and Immunosuppressive Effects of Turmeric Paste on 7, 12 Di Methyl Benz (a) Anthracene Induced Skin Tumor Model of Wistar Rat. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29029387&form=6&db=m The ?-NAD ongoing research,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29031068&form=6&db=m Platinum(IV) prodrugs multiply targeting genomic DNA, histone deacetylases and PARP-1. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29037806&form=6&db=m PARP inhibitors: Clinical utility and possibilities of overcoming resistance. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29040190&form=6&db=m Novel Therapeutics for Ovarian Cancer: The 11th Biennial Rivkin Center Ovarian Cancer Research Symposium. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29042365&form=6&db=m Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29043410&form=6&db=m Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29044514&form=6&db=m CCDC6: the identity of a protein known to be partner in fusion. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29045554&form=6&db=m Veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in patients with BRCA1/2 locally recurrent/metastatic breast cancer: randomized phase II study. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29059438&form=6&db=m Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29063620&form=6&db=m Predictive value of epithelial-mesenchymal-transition (EMT) signature and PARP-1 in prostate cancer radioresistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29075104&form=6&db=m Risk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: a meta-analysis of randomized controlled trials. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29087384&form=6&db=m PARPi focus the spotlight on replication fork protection in cancer. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29093017&form=6&db=m A Population of Heterogeneous Breast Cancer Patient-Derived Xenografts Demonstrate Broad Activity of PARP Inhibitor in BRCA1/2 Wild-Type Tumors. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29109859&form=6&db=m Candidate synthetic lethality partners to PARP inhibitors in the treatment of ovarian clear cell cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29111403&form=6&db=m The critical role of autophagy in cadmium-induced immunosuppression regulated by endoplasmic reticulum stress-mediated calpain activation in RAW264.7 mouse monocytes. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29112893&form=6&db=m Natural product ?-thujaplicin inhibits homologous recombination repair and sensitizes cancer cells to radiation therapy. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29113422&form=6&db=m Novel DNA targeted therapies for head and neck cancers: clinical potential and biomarkers. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29115461&form=6&db=m Histone deacetylase inhibition of cardiac autophagy in rats on a high?fat diet with low?dose streptozotocin-induced type 2 diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29116469&form=6&db=m BRCA1 deficiency is a recurrent event in early-onset triple-negative breast cancer: a comprehensive analysis of germline mutations and somatic promoter methylation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29133135&form=6&db=m Characterization, Detection, and Treatment Approaches for Homologous Recombination Deficiency in Cancer. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29133592&form=6&db=m PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29138343&form=6&db=m A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29152062&form=6&db=m Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29152107&form=6&db=m Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29158484&form=6&db=m The HSF1-PARP13-PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29158830&form=6&db=m Sustained Release Talazoparib Implants for Localized Treatment of therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29169419&form=6&db=m [Aspirin inhibits the proliferation of breast cancer cells via inducing apoptosis and autophagy]. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29179487&form=6&db=m PARP-1 promotes tumor recurrence after warm ischemic liver graft transplantation via neutrophil recruitment and polarization. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29185084&form=6&db=m A triazole-conjugated benzoxazone induces reactive oxygen species and promotes autophagic apoptosis in human lung cancer cells. causal interaction,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29196784&form=6&db=m PARP1 protects from benzo[a]pyrene diol epoxide-induced replication stress and mutagenicity. ongoing research,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29199015&form=6&db=m Contemporary prognostic indicators for prostate cancer incorporating International Society of Urological Pathology recommendations. causal interaction,diagnostic usage,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29207595&form=6&db=m CDK1 promotes nascent DNA synthesis and induces resistance of cancer cells to DNA-damaging therapeutic agents. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29207607&form=6&db=m Cyclin A2 regulates homologous recombination DNA repair and sensitivity to DNA damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors in human breast cancer cells. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29209638&form=6&db=m Sensitizing HR-proficient cancers to PARP inhibitors. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29212245&form=6&db=m RBR-type E3 ubiquitin ligase RNF144A targets PARP1 for ubiquitin-dependent degradation and regulates PARP inhibitor sensitivity in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29214031&form=6&db=m PARP inhibitors as potential therapeutic agents for various cancers: focus on niraparib and its first global approval for maintenance therapy of gynecologic cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29217266&form=6&db=m Auriculasin-induced ROS causes prostate cancer cell death via induction of apoptosis. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29223478&form=6&db=m Phase II trial of veliparib in patients with previously treated BRCA-mutated pancreas ductal adenocarcinoma. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29238179&form=6&db=m Role of poly (ADP-ribose) polymerase-1 and cytokines in acute renal injury in elderly Chinese patients with diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29251678&form=6&db=m Novel poly-ADP-ribose polymerase inhibitor combination strategies in ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29254481&form=6&db=m Melanoma cells replicate through chemotherapy by reducing levels of key homologous recombination protein RAD51 and increasing expression of translesion synthesis DNA polymerase ?. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29256493&form=6&db=m BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29260919&form=6&db=m The development of PARP as a successful target for cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29262321&form=6&db=m BET Bromodomain Inhibition Synergizes with PARP Inhibitor in Epithelial Ovarian Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29262611&form=6&db=m PARP inhibition causes premature loss of cohesion in cancer cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29273547&form=6&db=m [Molecular characterisation defines several subtypes of pancreatic ductal adenocarcinoma]. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29274141&form=6&db=m Acquired resistance of phosphatase and tensin homolog-deficient cells to poly(ADP-ribose) polymerase inhibitor and Ara-C mediated by 53BP1 loss and SAMHD1 overexpression. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29280214&form=6&db=m Thorough in silico and in vitro cDNA analysis of 21 putative BRCA1 and BRCA2 splice variants and a complex tandem duplication in BRCA2 allowing the identification of activated cryptic splice donor sites in BRCA2 exon 11. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29282689&form=6&db=m BRCA Gene Mutations and Poly(ADP-Ribose) Polymerase Inhibitors in Triple-Negative Breast Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29285982&form=6&db=m Effects of veliparib on microglial activation and functional outcomes following traumatic brain injury in the rat and pig. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29305260&form=6&db=m Irigenin sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29306194&form=6&db=m Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29313279&form=6&db=m A phase 1 study of PARP-inhibitor ABT-767 in advanced solid tumors with BRCA1/2 mutations and high-grade serous ovarian, fallopian tube, or primary peritoneal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29313444&form=6&db=m Poly (ADP-ribose) polymerase inhibitors in the management of ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29327913&form=6&db=m Proteomic Analysis of the Downstream Signaling Network of PARP1. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29348879&form=6&db=m Loss of NEIL3 DNA glycosylase markedly increases replication associated double strand breaks and enhances sensitivity to ATR inhibitor in glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29352572&form=6&db=m Phase I combination study of the PARP inhibitor veliparib plus carboplatin and gemcitabine in patients with advanced ovarian cancer and other solid malignancies. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29371919&form=6&db=m Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29393407&form=6&db=m PARP1-siRNA suppresses human prostate cancer cell growth and progression. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29398485&form=6&db=m Risk-Associated Long Noncoding RNA FOXD3-AS1 Inhibits Neuroblastoma Progression by Repressing PARP1-Mediated Activation of CTCF. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29409480&form=6&db=m Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29413287&form=6&db=m PARP Inhibition Combined With Thoracic Irradiation Exacerbates Esophageal and Skin Toxicity in C57BL6 Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29414021&form=6&db=m Development and validation of a high-performance liquid chromatography method for the quantitation of intracellular PARP inhibitor Olaparib in cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29421518&form=6&db=m miR-7-5p overexpression suppresses cell proliferation and promotes apoptosis through inhibiting the ability of DNA damage repair of PARP-1 and BRCA1 in TK6 cells exposed to hydroquinone. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29423093&form=6&db=m Combination of a hypomethylating agent and inhibitors of PARP and HDAC traps PARP1 and DNMT1 to chromatin, acetylates DNA repair proteins, down-regulates NuRD and induces apoptosis in human leukemia and lymphoma cells. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29427345&form=6&db=m Crosstalk of DNA double-strand break repair pathways in poly(ADP-ribose) polymerase inhibitor treatment of breast cancer susceptibility gene 1/2-mutated cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29467487&form=6&db=m Loss of heterozygosity as a marker of homologous repair deficiency in multiple myeloma: a role for PARP inhibition? causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29472838&form=6&db=m Cancer Imprints an Increased PARP-1 and p53-Dependent Resistance to Oxidative Stress on Lymphocytes of Patients That Later Develop Alzheimer's Disease. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29479816&form=6&db=m PARP inhibitor olaparib sensitizes cholangiocarcinoma cells to radiation. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29505040&form=6&db=m Risk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: results of monotherapy and combination therapy trials. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29509546&form=6&db=m A PET imaging agent for evaluating PARP-1 expression in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29511213&form=6&db=m Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29511347&form=6&db=m PARP-1 inhibition with or without ionizing radiation confers reactive oxygen species-mediated cytotoxicity preferentially to cancer cells with mutant TP53. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29513652&form=6&db=m EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29514732&form=6&db=m ERRATUM. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29515234&form=6&db=m PARP10 suppresses tumor metastasis through regulation of Aurora A activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29521233&form=6&db=m Parp Inhibitors for the Treatment of Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29526802&form=6&db=m The poly(ADP-ribose) polymerase inhibitor olaparib induces up-regulation of death receptors in primary acute myeloid leukemia blasts by NF-?B activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29530602&form=6&db=m Drug-induced xenogenization of tumors: A possible role in the immune control of malignant cell growth in the brain? causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29575811&form=6&db=m Selenadiazole derivatives inhibit angiogenesis-mediated human breast tumor growth through suppressing VEGFR2-mediated ERK and AKT signaling pathway. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29582320&form=6&db=m Soft tissue sarcomas: new opportunity of treatment with PARP inhibitors? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29590171&form=6&db=m PARP1 depletion induces RIG-I-dependent signaling in human cancer cells. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29592880&form=6&db=m Trastuzumab resistant HER2+ breast cancer cells retain sensitivity to poly (ADP-ribose) polymerase (PARP) inhibition. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29592899&form=6&db=m Synthetic Lethality of PARP Inhibition and Ionizing Radiation is p53-dependent. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29606109&form=6&db=m Neoadjuvant degarelix with or without apalutamide followed by radical prostatectomy for intermediate and high-risk prostate cancer: ARNEO, a randomized, double blind, placebo-controlled trial. diagnostic usage,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29615218&form=6&db=m Placental promoter methylation of DNA repair genes and prenatal exposure to particulate air pollution: an ENVIRONAGE cohort study. diagnostic usage,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29616088&form=6&db=m Retrospective screening of microarray data to identify candidate IFN-inducible genes in a HTLV-1 transformed model. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29620474&form=6&db=m Pharmacokinetic drug evaluation of niraparib for the treatment of ovarian cancer. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29621593&form=6&db=m Double-barreled gun: Combination of PARP inhibitor with conventional chemotherapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29630818&form=6&db=m An 18F-Labeled Poly(ADP-ribose) Polymerase Positron Emission Tomography Imaging Agent. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29632181&form=6&db=m PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29635130&form=6&db=m Avicularin reversed multidrug-resistance in human gastric cancer through enhancing Bax and BOK expressions. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29635390&form=6&db=m RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29649003&form=6&db=m Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29650751&form=6&db=m FDA Approval Summary: Niraparib for the Maintenance Treatment of Patients with Recurrent Ovarian Cancer in Response to Platinum-Based Chemotherapy. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29650809&form=6&db=m [Molecular Targeted Therapies for Hereditary Cancer Syndrome]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29651367&form=6&db=m "Lazarus Response" to Olaparib in a Virtually Chemonaive Breast Cancer Patient Carrying Gross BRCA2 Gene Deletion. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29654063&form=6&db=m A Short BRCA2-Derived Cell-Penetrating Peptide Targets RAD51 Function and Confers Hypersensitivity toward PARP Inhibition. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29660759&form=6&db=m PARP inhibitors in breast cancer: Bringing synthetic lethality to the bedside. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29664016&form=6&db=m The evolving landscape of predictive biomarkers of response to PARP inhibitors. diagnostic usage,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29664094&form=6&db=m Analysis of poly(ADP-ribose) polymerase-1 by enzyme-initiated auto-PARylation-controlled aggregation of hemin-graphene nanocomposites. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29668451&form=6&db=m A Review on DNA Repair Inhibition by PARP Inhibitors in Cancer Therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29703482&form=6&db=m Anti-angiogenesis for cancer: Current status and prospects. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29743861&form=6&db=m Pinus Roxburghii essential oil anticancer activity and chemical composition evaluation. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29748565&form=6&db=m Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29753417&form=6&db=m Persistent depletion of plasma gelsolin (pGSN) after exposure of mice to heavy silicon ions. diagnostic usage,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29767248&form=6&db=m Combined treatment with PI3K inhibitor BKM120 and PARP inhibitor olaparib is effective in inhibiting the gastric cancer cells with ARID1A deficiency. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29767688&form=6&db=m Safety and dose modification for patients receiving niraparib. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29768208&form=6&db=m The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29770446&form=6&db=m Anticancer activity of tetrandrine by inducing pro-death apoptosis and autophagy in human gastric cancer cells. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29774075&form=6&db=m Plectin-targeted liposomes enhance the therapeutic efficacy of a PARP inhibitor in the treatment of ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29775573&form=6&db=m Indole-3-Carbinol (I3C) enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin (DOX) through inhibition of NF-??, blocking angiogenesis and regulation of mitochondrial apoptotic pathway. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29784639&form=6&db=m Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors. causal interaction,diagnostic usage,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29788099&form=6&db=m Biomarkers for Homologous Recombination Deficiency in Cancer. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29789392&form=6&db=m FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29792535&form=6&db=m Does the Poly (ADP-Ribose) Polymerase Inhibitor Veliparib Merit Further Study for Cancer-Associated Weight Loss? Observations and Conclusions from Sixty Prospectively Treated Patients. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29795234&form=6&db=m Comparative inhibitory profile and distribution of bacterial PARPs, using Clostridioides difficile CD160 PARP as a model. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29799676&form=6&db=m Pharmacokinetic Study of Rucaparib in Patients With Advanced Solid Tumors. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29812960&form=6&db=m PARP-1 Overexpression as an Independent Prognostic Factor in Adult Non-M3 Acute Myeloid Leukemia. causal interaction,diagnostic usage,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29842822&form=6&db=m Biosynthesized composites of Au-Ag nanoparticles using Trapa peel extract induced ROS-mediated p53 independent apoptosis in cancer cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29856625&form=6&db=m Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29866945&form=6&db=m The Importance of Distinguishing Sporadic Cancers from Those Related to Cancer Predisposing Germline Mutations. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29871906&form=6&db=m PARP Inhibitors in Ovarian Cancer: A Trailblazing and Transformative Journey. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29879343&form=6&db=m [Olaparib potentiates the antitumor effect of Taxol on 4T1 breast cancer]. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29880585&form=6&db=m MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29898385&form=6&db=m Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29902865&form=6&db=m Co-targeting poly(ADP-ribose) polymerase (PARP) and histone deacetylase (HDAC) in triple-negative breast cancer: Higher synergism in BRCA mutated cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29906251&form=6&db=m Randomized, Double-Blind, Phase II Study of Temozolomide in Combination With Either Veliparib or Placebo in Patients With Relapsed-Sensitive or Refractory Small-Cell Lung Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29917049&form=6&db=m Breast cancer brain metastases show increased levels of genomic aberration-based homologous recombination deficiency scores relative to their corresponding primary tumors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29923797&form=6&db=m Valproate augments Niraparib killing of tumor cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29928967&form=6&db=m Castalagin and vescalagin purified from leaves of Syzygium samarangense (Blume) Merrill & L.M. Perry: Dual inhibitory activity against PARP1 and DNA topoisomerase II. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29941481&form=6&db=m The Combination of the PARP Inhibitor Olaparib and the WEE1 Inhibitor AZD1775 as a New Therapeutic Option for Small Cell Lung Cancer. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29945991&form=6&db=m Talazoparib Is a Potent Radiosensitizer in Small Cell Lung Cancer Cell Lines and Xenografts. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29955114&form=6&db=m Synthetic lethal therapies for cancer: what's next after PARP inhibitors? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29955143&form=6&db=m Refinement of high-risk endometrial cancer classification using DNA damage response biomarkers: a TransPORTEC initiative. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29959202&form=6&db=m Dual Targeting of ERBB2/ERBB3 for the Treatment of SLC3A2-NRG1-Mediated Lung Cancer. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29961065&form=6&db=m Verbascoside Inhibits Glioblastoma Cell Proliferation, Migration and Invasion While Promoting Apoptosis Through Upregulation of Protein Tyrosine Phosphatase SHP-1 and Inhibition of STAT3 Phosphorylation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29970481&form=6&db=m Inhibition of Parp1 by BMN673 Effectively Sensitizes Cells to Radiotherapy by Upsetting the Balance of Repair Pathways Processing DNA Double-Strand Breaks. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29973717&form=6&db=m CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29974335&form=6&db=m Discriminating radiation injury from recurrent tumor with [18F]PARPi and amino acid PET in mouse models. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29976574&form=6&db=m Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29976663&form=6&db=m PARP1 Stabilizes CTCF Binding and Chromatin Structure To Maintain Epstein-Barr Virus Latency Type. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29979319&form=6&db=m Relevance of poly (ADP-ribose) polymerase inhibitors in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29981726&form=6&db=m New chalcone derivative exhibits antiproliferative potential by inducing G2/M cell cycle arrest, mitochondrial-mediated apoptosis and modulation of MAPK signalling pathway. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29983087&form=6&db=m Can Poly (ADP-Ribose) Polymerase Inhibitors Palliate Paclitaxel-Induced Peripheral Neuropathy in Patients With Cancer? therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29983873&form=6&db=m Simultaneous delivery of olaparib and carboplatin in PEGylated liposomes imparts this drug combination hypersensitivity and selectivity for breast tumor cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29998112&form=6&db=m New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30006631&form=6&db=m Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30010248&form=6&db=m Design and Synthesis of DNA-Interactive ?-Carboline-Oxindole Hybrids as Cytotoxic and Apoptosis-Inducing Agents. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30010936&form=6&db=m ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30012480&form=6&db=m Apoptotic and antiproliferative effects of Stigmast-5-en-3-ol from Dendronephthya gigantea on human leukemia HL-60 and human breast cancer MCF-7 cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30013063&form=6&db=m Acetylation blocks DNA damage-induced chromatin ADP-ribosylation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30019842&form=6&db=m Antitumor activity of RT2 peptide derived from crocodile leukocyte peptide on human colon cancer xenografts in nude mice. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30020984&form=6&db=m Potential biomarkers and therapeutic targets in cervical cancer: Insights from the meta-analysis of transcriptomics data within network biomedicine perspective. diagnostic usage,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30022119&form=6&db=m Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30022158&form=6&db=m 53BP1-RIF1-shieldin counteracts DSB resection through CST- and Pol?-dependent fill-in. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30022168&form=6&db=m The shieldin complex mediates 53BP1-dependent DNA repair. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30025822&form=6&db=m Radiosensitization by the PARP inhibitor olaparib in BRCA1-proficient and deficient high-grade serous ovarian carcinomas. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30032250&form=6&db=m PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30032296&form=6&db=m Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30036195&form=6&db=m Inherited gynaecological cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30046392&form=6&db=m Epigenetic activation of HORMAD1 in basal-like breast cancer: role in Rucaparib sensitivity. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30046848&form=6&db=m Identification and preclinical characterization of a novel and potent poly (ADP-ribose) polymerase (PARP) inhibitor ZYTP1. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30051098&form=6&db=m Rucaparib Monotherapy in Patients With Pancreatic Cancer and a Known Deleterious BRCA Mutation. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30067621&form=6&db=m Development of poly(ADP-ribose) polymerase inhibitors in the treatment of BRCA-mutated breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30073633&form=6&db=m Niraparib: A Review in Ovarian Cancer. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30080919&form=6&db=m Using PARP Inhibitors in Advanced Ovarian Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30081229&form=6&db=m Replication stress response in cancer stem cells as a target for chemotherapy. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30099369&form=6&db=m DNA Repair Gene Alterations and PARP Inhibitor Response in Patients With Metastatic Castration-Resistant Prostate Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30101194&form=6&db=m Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30106450&form=6&db=m Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR/Akt signaling and predicts a good prognosis in non?small cell lung cancer. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30108102&form=6&db=m Kub5-Hera RPRD1B Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30108714&form=6&db=m Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30116283&form=6&db=m Advances in the use of PARP inhibitor therapy for breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30127642&form=6&db=m The efficacy and safety of olaparib in the treatment of cancers: a meta-analysis of randomized controlled trials. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30131605&form=6&db=m BRCAness and prostate cancer: diagnostic and therapeutic considerations. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30135856&form=6&db=m Targeting Cyclin-Dependent Kinases for Treatment of Gynecologic Cancers. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30139880&form=6&db=m Functional Ex Vivo Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30140387&form=6&db=m Interaction between N-cadherin and decoy receptor-2 regulates apoptosis in head and neck cancer. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30150436&form=6&db=m Antitumor Ability of KT2 Peptide Derived from Leukocyte Peptide of Crocodile Against Human HCT116 Colon Cancer Xenografts. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30150591&form=6&db=m Synthesis, Bacteriostatic and Anticancer Activity of Novel Phenanthridines Structurally Similar to Benzo[c]phenanthridine Alkaloids. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30152517&form=6&db=m PARP inhibitors synergize with gemcitabine by potentiating DNA damage in non-small-cell lung cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30166110&form=6&db=m Hexane fraction of adlay (Coix lachryma-jobi L.) testa ethanolic extract inhibits human uterine sarcoma cancer cells growth and chemosensitizes human uterine sarcoma cells to doxorubicin. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30177437&form=6&db=m Mechanisms of PARP inhibitor sensitivity and resistance. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30178242&form=6&db=m Genomic Profiling and Potentially Targetable Alterations in Pancreatic Ductal Adenocarcinoma. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30181424&form=6&db=m Resurrection of PARP Inhibitors in Breast Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30184433&form=6&db=m Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30185546&form=6&db=m HORMAD1 is a negative prognostic indicator in lung adenocarcinoma and specifies resistance to oxidative and genotoxic stress. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30193098&form=6&db=m Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-?B Signaling after Nuclear DNA Damage. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30195072&form=6&db=m Preliminary evaluation of a novel 18F-labeled PARP-1 ligand for PET imaging of PARP-1 expression in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30198004&form=6&db=m Altering Nitrogen Heterocycles of AZD2461 Affords High Affinity Poly(ADP-ribose) Polymerase-1 Inhibitors with Decreased P-Glycoprotein Interactions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30201826&form=6&db=m Repurposing of mTOR Complex Inhibitors Attenuates MCL-1 and Sensitizes to PARP Inhibition. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30203184&form=6&db=m Targeted Therapy and Immune Therapy for Small Cell Lung Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30203829&form=6&db=m Synthesis of disaccharide nucleoside analogues as potential poly(ADP-ribose) polymerase-1 inhibitors. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30215333&form=6&db=m DNA repair proteins as therapeutic targets in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30230653&form=6&db=m Optimizing PARP inhibition through combined epigenetic and immunotherapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30231328&form=6&db=m Innovative Strategies: Targeting Subtypes in Metastatic Breast Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30231353&form=6&db=m Moving From Mutation to Actionability. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30234015&form=6&db=m MicroRNAs and DNA-Damaging Drugs in Breast Cancer: Strength in Numbers. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30242511&form=6&db=m Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30245085&form=6&db=m Mutational Profile of Aggressive, Localised Prostate Cancer from African Caribbean Men Versus European Ancestry Men. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30257212&form=6&db=m BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30258223&form=6&db=m Isolation of 4,4'-bond secalonic acid D from the marine-derived fungus Penicillium oxalicum with inhibitory property against hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30269007&form=6&db=m Restored replication fork stabilization, a mechanism of PARP inhibitor resistance, can be overcome by cell cycle checkpoint inhibition. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30271949&form=6&db=m PARP1 activation increases expression of modified tumor suppressors and pathways underlying development of aggressive hepatoblastoma. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30274183&form=6&db=m Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30275858&form=6&db=m Expression of DNA Damage Response Proteins and Associations with Clinicopathologic Characteristics in Chinese Familial Breast Cancer Patients with BRCA1/2 Mutations. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30289618&form=6&db=m HMGA2 as a functional antagonist of PARP1 inhibitors in tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30297533&form=6&db=m Targeting PARP1 in XRCC1 deficient sporadic invasive breast cancer or pre-invasive ductal carcinoma in situ induces synthetic lethality and chemoprevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30297868&form=6&db=m Pyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30306576&form=6&db=m Targeted therapy for gynecologic cancers: Toward the era of precision medicine. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30327308&form=6&db=m A Phase I Dose-Escalation Study of Veliparib Combined with Carboplatin and Etoposide in Patients with Extensive-Stage Small Cell Lung Cancer and Other Solid Tumors. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30333000&form=6&db=m Response to olaparib in metastatic castration-resistant prostate cancer with germline BRCA2 mutation: a case report. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30341419&form=6&db=m Cell death in cancer in the era of precision medicine. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30345412&form=6&db=m Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30348635&form=6&db=m The Ewing Family of Tumors Relies on BCL-2 and BCL-XL to Escape PARP Inhibitor Toxicity. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30352801&form=6&db=m Improved Therapeutic Window in BRCA-mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30353044&form=6&db=m Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30356138&form=6&db=m State-of-the-art strategies for targeting the DNA damage response in cancer. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30357520&form=6&db=m PARP inhibitors affect growth, survival and radiation susceptibility of human alveolar and embryonal rhabdomyosarcoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30377213&form=6&db=m A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30384258&form=6&db=m Dihomo-?-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30389822&form=6&db=m PET imaging of PARP expression using [18F]olaparib. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30391013&form=6&db=m Biomarker-driven and molecularly targeted therapies for pancreatic adenocarcinoma. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30395643&form=6&db=m Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30400006&form=6&db=m ATM deficiency promotes progression of CRPC by enhancing Warburg effect. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30401677&form=6&db=m PARP1 Suppresses the Transcription of PD-L1 by Poly(ADP-Ribosyl)ating STAT3. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30407325&form=6&db=m Response of germline BRCA2-mutated advanced pancreatic acinar cell carcinoma to olaparib: A case report. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30410539&form=6&db=m Overexpression of IRS-4 Correlates with Procaspase 3 Levels in Tumoural Tissue of Patients with Colorectal Cancer. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30410680&form=6&db=m PARP1 is required for preserving telomeric integrity but is dispensable for A-NHEJ. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30414739&form=6&db=m Cyclin D1 silencing impairs DNA double strand break repair, sensitizes BRCA1 wildtype ovarian cancer cells to olaparib. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30417796&form=6&db=m Poly (ADP-Ribose) Polymerases (PARPs) and PARP Inhibitor-Targeted Therapeutics. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30425037&form=6&db=m BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,2 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30425352&form=6&db=m Long-term treatment with the PARP inhibitor niraparib does not increase the mutation load in cell line models and tumour xenografts. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30425572&form=6&db=m The novel mechanism of anticancer effect on gastric cancer through inducing G0/G1 cell cycle arrest and caspase-dependent apoptosis in vitro and in vivo by methionine enkephalin. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30427217&form=6&db=m Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30427259&form=6&db=m Discovery of a novel DNA polymerase inhibitor and characterization of its antiproliferative properties. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30427584&form=6&db=m Evaluation of Drug-Drug Interactions of Rucaparib and CYP1A2, CYP2C9, CYP2C19, CYP3A, and P-gp Substrates in Patients With an Advanced Solid Tumor. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30429199&form=6&db=m Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP Inhibitors In Vitro and In Vivo. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30429212&form=6&db=m PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30442946&form=6&db=m PARP3, a new therapeutic target to alter Rictor/mTORC2 signaling and tumor progression in BRCA1-associated cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30450033&form=6&db=m METH-Induced Neurotoxicity Is Alleviated by Lactulose Pretreatment Through Suppressing Oxidative Stress and Neuroinflammation in Rat Striatum. diagnostic usage,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30452211&form=6&db=m [Specific features of drug sensitivity of hereditary cancers]. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30456461&form=6&db=m Olaparib Tablet: A Review in Ovarian Cancer Maintenance Therapy. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30467127&form=6&db=m PARP-1 regulates DNA repair factor availability. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30470508&form=6&db=m Loss of the p12 subunit of DNA polymerase delta leads to a defect in HR and sensitization to PARP inhibitors. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30472087&form=6&db=m High PARP-1 expression predicts poor survival in acute myeloid leukemia and PARP-1 inhibitor and SAHA-bendamustine hybrid inhibitor combination treatment synergistically enhances anti-tumor effects. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30478677&form=6&db=m Effects of long-term dehydration on oxidative stress, apoptotic markers and neuropeptides in the gastric mucosa of the dromedary camel. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30482774&form=6&db=m PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30485824&form=6&db=m Integrated Genomic, Epigenomic, and Expression Analyses of Ovarian Cancer Cell Lines. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30487462&form=6&db=m Combining PARP inhibition, radiation, and immunotherapy: A possible strategy to improve the treatment of cancer? therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30487607&form=6&db=m CDK12 regulates DNA repair genes by suppressing intronic polyadenylation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30488748&form=6&db=m Assessment of the in vitro cytochrome P450 (CYP) inhibition potential of ZYTP1, a novel poly (ADP-ribose) polymerase inhibitor. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30498082&form=6&db=m Replication Stress: An Achilles' Heel of Glioma Cancer Stem-like Cells. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30498083&form=6&db=m Development of PARP and Immune-Checkpoint Inhibitor Combinations. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30506342&form=6&db=m Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30518089&form=6&db=m Role of BRCA Mutations in Cancer Treatment with Poly(ADP-ribose) Polymerase (PARP) Inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30518186&form=6&db=m Assessment of the Inhibitory Effects of Ficin-hydrolyzed Gelatin Derived from Squid (Uroteuthis duvauceli) on Breast Cancer Cell Lines and Animal Model. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30520109&form=6&db=m Ex vivo treatment of prostate tumor tissue recapitulates in vivo therapy response. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30521889&form=6&db=m Glucuronorhamnoxylan from Capsosiphon fulvescens inhibits the growth of HT-29 human colon cancer cells in vitro and in vivo via induction of apoptotic cell death. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30525097&form=6&db=m Cisplatin resistance coupled to enhanced sensitivity to metabolic interventions. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30530501&form=6&db=m Radiosensitivity Is an Acquired Vulnerability of PARPi-Resistant BRCA1-Deficient Tumors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30540581&form=6&db=m Poly-ADP-ribosyl-polymerase inhibitor resistance mechanisms and their therapeutic implications. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30540933&form=6&db=m PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30543656&form=6&db=m Sensitivity to inhibition of DNA repair by Olaparib in novel oropharyngeal cancer cell lines infected with Human Papillomavirus. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30551210&form=6&db=m Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30559256&form=6&db=m NF?B and Poly (ADP-ribose) Polymerase 1 Form a Positive Feedback Loop that Regulates DNA Repair in Acute Myeloid Leukemia Cells. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30573522&form=6&db=m EGFR and c-MET Cooperate to Enhance Resistance to PARP Inhibitors in Hepatocellular Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30576655&form=6&db=m USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30583807&form=6&db=m Olaparib: A tale of two dosage forms. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30589644&form=6&db=m PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30593284&form=6&db=m Mechanisms of PARP inhibitor resistance in cancer and insights into the DNA damage response. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30612738&form=6&db=m UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30614472&form=6&db=m Exploring and comparing adverse events between PARP inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30615982&form=6&db=m Synergistic Cytotoxic Effect of Busulfan and the PARP Inhibitor Veliparib in Myeloproliferative Neoplasms. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30617135&form=6&db=m NQO1-dependent, tumor-selective radiosensitization of non-small cell lung cancers. diagnostic usage,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30622026&form=6&db=m ONS-donor ligand based Pt(II) complexes display extremely high anticancer potency through autophagic cell death pathway. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30636012&form=6&db=m DNA Damage Repair Alterations are Frequent in Prostatic Adenocarcinomas with Focal Pleomorphic Giant Cell Features. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30647846&form=6&db=m A comparative pharmacokinetic study of PARP inhibitors demonstrates favorable properties for niraparib efficacy in preclinical tumor models. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30647872&form=6&db=m Overexpression of PARP is an independent prognostic marker for poor survival in Middle Eastern breast cancer and its inhibition can be enhanced with embelin co-treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30648820&form=6&db=m Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655555&form=6&db=m A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655783&form=6&db=m Su Yang Decoction induces human colon carcinoma cell apoptosis by activating caspases. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30656896&form=6&db=m BRCA1 deficiency and synthetic lethality in leukemias; not only gene mutation matters. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30658107&form=6&db=m F-Box Protein-Mediated Resistance to PARP Inhibitor Therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30672100&form=6&db=m PARP inhibitors in ovarian cancer: Sensitivity prediction and resistance mechanisms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30674894&form=6&db=m Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30675909&form=6&db=m Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicity. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30678630&form=6&db=m Reverse Screening Bioinformatics Approach to Identify Potential Anti Breast Cancer Targets Using Thymoquinone from Neutraceuticals Black Cumin Oil. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30680521&form=6&db=m Effect of niraparib on cardiac repolarization in patients with platinum-sensitive, recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30680959&form=6&db=m Interaction of germline variants in a family with a history of early-onset clear cell renal cell carcinoma. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30681819&form=6&db=m Current treatment landscape and emerging therapies for pancreatic cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30683261&form=6&db=m Personalized Medicine in Gynecologic Cancer: Fact or Fiction? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30684797&form=6&db=m Medicinal chemistry approaches of poly ADP-Ribose polymerase 1 (PARP1) inhibitors as anticancer agents - A recent update. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30684955&form=6&db=m Phase I clinical study of oral olaparib in pediatric patients with refractory solid tumors: study protocol. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30686551&form=6&db=m 53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30691122&form=6&db=m PARP-1/2 Inhibitor Olaparib Prevents or Partially Reverts EMT Induced by TGF-? in NMuMG Cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30692098&form=6&db=m BRCA1 Promoter Methylation Is Linked to Defective Homologous Recombination Repair and Elevated miR-155 to Disrupt Myeloid Differentiation in Myeloid Malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30693808&form=6&db=m Cepharanthine combined with 5-fluorouracil inhibits the growth of p53-mutant human colorectal cancer cells. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30717758&form=6&db=m Loss of NFBD1/MDC1 disrupts homologous recombination repair and sensitizes nasopharyngeal carcinoma cells to PARP inhibitors. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30723695&form=6&db=m PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30733193&form=6&db=m Phosphatase 1 nuclear targeting subunit mediates recruitment and function of poly (ADP-ribose) polymerase 1 in DNA repair. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30738018&form=6&db=m Estradiol and progesterone regulate proliferation and apoptosis in colon cancer. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30741544&form=6&db=m (-)-Epigallocatechin Gallate (EGCG) Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU by Inhibiting GRP78/NF-?B/miR-155-5p/MDR1 Pathway. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30741937&form=6&db=m NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30743082&form=6&db=m Identification and quantification of DNA repair protein poly(ADP ribose) polymerase 1 (PARP1) in human tissues and cultured cells by liquid chromatography/isotope-dilution tandem mass spectrometry. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30755715&form=6&db=m Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30760478&form=6&db=m PARP Inhibitors: Extending Benefit Beyond BRCA Mutant Cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30778617&form=6&db=m Integrin-independent support of cancer drug resistance by tetraspanin CD151. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30782572&form=6&db=m Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30788663&form=6&db=m Inhibition of MEK suppresses hepatocellular carcinoma growth through independent MYC and BIM regulation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30791940&form=6&db=m New combinatorial strategies to improve the PARP inhibitors efficacy in the urothelial bladder Cancer treatment. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30797591&form=6&db=m ERCC1-XPF deficiency is a predictor of olaparib induced synthetic lethality and platinum sensitivity in epithelial ovarian cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30806045&form=6&db=m Major clinical research advances in gynecologic cancer in 2018. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30824778&form=6&db=m PARP1 rs1805407 Increases Sensitivity to PARP1 Inhibitors in Cancer Cells Suggesting an Improved Therapeutic Strategy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30833416&form=6&db=m Response to olaparib in a PALB2 germline mutated prostate cancer and genetic events associated with resistance. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30834527&form=6&db=m Combination therapy with dacarbazine and statins improved the survival rate in mice with metastatic melanoma. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30836272&form=6&db=m RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30842276&form=6&db=m MDA-7/IL-24 regulates the miRNA processing enzyme DICER through downregulation of MITF. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30844273&form=6&db=m Discovery of Novel Bromophenol-Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase-1 (PARP-1) for Use in Cancer. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30851349&form=6&db=m Characterisation of Deubiquitylating Enzymes in the Cellular Response to High-LET Ionizing Radiation and Complex DNA Damage. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30854033&form=6&db=m Combinatorial therapy of immune checkpoint and cancer pathways provides a novel perspective on ovarian cancer treatment. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30857227&form=6&db=m Clinical Stratification of High-Grade Ovarian Serous Carcinoma Using a Panel of Six Biomarkers. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30857266&form=6&db=m Identification of Novel Interaction Partners of Ets-1: Focus on DNA Repair. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30864743&form=6&db=m PARG regulates the proliferation and differentiation of DCs and T cells via PARP/NF??B in tumour metastases of colon carcinoma. diagnostic usage,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30873673&form=6&db=m Cationic liposome codelivering PI3K pathway regulator improves the response of BRCA1-deficient breast cancer cells to PARP1 inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30874560&form=6&db=m The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30877373&form=6&db=m Bone marrow PARP1 mRNA levels predict response to treatment with 5-azacytidine in patients with myelodysplastic syndrome. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30889377&form=6&db=m Capitalizing on Cancer Replication Stress by Preventing PAR Chain Turnover: A New Type of Synthetic Lethality. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30889466&form=6&db=m Nitric oxide-donor/PARP-inhibitor combination: A new approach for sensitization to ionizing radiation. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30890936&form=6&db=m Research Progress on PARP14 as a Drug Target. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30894073&form=6&db=m Loss of MIEF1/MiD51 confers susceptibility to BAX-mediated cell death and PINK1-PRKN-dependent mitophagy. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30895466&form=6&db=m PARP Inhibitors and the Evolving Landscape of Ovarian Cancer Management: A Review. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30897045&form=6&db=m PET of Poly (ADP-Ribose) Polymerase Activity in Cancer: Preclinical Assessment and First In-Human Studies. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30898650&form=6&db=m MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30911963&form=6&db=m Mitigating effect of biotin against irradiation-induced cerebral cortical and hippocampal damage in the rat brain tissue. causal interaction,diagnostic usage,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30912451&form=6&db=m Advances in the use of PARP inhibitors for BRCA1/2-associated breast cancer: talazoparib. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30923663&form=6&db=m Single-particle analysis of full-length human poly(ADP-ribose) polymerase 1. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930233&form=6&db=m Cardiac glycoside cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30931334&form=6&db=m Ethanol Extract of Securidaca longipedunculata Induces Apoptosis in Brain Tumor (U87) Cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30934991&form=6&db=m PARP Inhibitors as a Therapeutic Agent for Homologous Recombination Deficiency in Breast Cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30940648&form=6&db=m Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30949414&form=6&db=m Synergism of PARP inhibitor fluzoparib (HS10160) and MET inhibitor HS10241 in breast and ovarian cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30949688&form=6&db=m Combined tumor sequencing and case/control analyses of RAD51C in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30952721&form=6&db=m Synergistic Effects of Olaparib and DNA-damaging Agents in Oesophageal Squamous Cell Carcinoma Cell Lines. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30953707&form=6&db=m Partnering with PARP inhibitors in acute myeloid leukemia with FLT3-ITD. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30968979&form=6&db=m PARP14 promotes the proliferation and gemcitabine chemoresistance of pancreatic cancer cells through activation of NF-?B pathway. causal interaction,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30970513&form=6&db=m Synthesis of coumarin analogs appended with quinoline and thiazole moiety and their apoptogenic role against murine ascitic carcinoma. causal interaction,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30971823&form=6&db=m WRN helicase is a synthetic lethal target in microsatellite unstable cancers. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30979843&form=6&db=m Deleterious somatic variants in 473 consecutive individuals with ovarian cancer: results of the observational AGO-TR1 study (NCT02222883). unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30985039&form=6&db=m Adjunctive Chinese herbal medicine therapy for nasopharyngeal carcinoma: Clinical evidence and experimental validation. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30989114&form=6&db=m Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30993586&form=6&db=m Midkine silencing enhances the anti-prostate cancer stem cell activity of the flavone apigenin: cooperation on signaling pathways regulated by ERK, p38, PTEN, PARP, and NF-?B. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30996287&form=6&db=m Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30996792&form=6&db=m Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30998513&form=6&db=m Poly (ADP-ribose) polymerase inhibitors combined with other small-molecular compounds for the treatment of ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31000582&form=6&db=m GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31013702&form=6&db=m Germline Missense Variants in BRCA1: New Trends and Challenges for Clinical Annotation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31015319&form=6&db=m PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31015914&form=6&db=m Telomerase and poly(ADP-ribose) polymerase-1 activity sensing based on the high fluorescence selectivity and sensitivity of TOTO-1 towards G bases in single-stranded DNA and poly(ADP-ribose). causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31027376&form=6&db=m Mortalin (GRP75/HSPA9) Promotes Survival and Proliferation of Thyroid Carcinoma Cells. causal interaction,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31029033&form=6&db=m DAXX, as a Tumor Suppressor, Impacts DNA Damage Repair and Sensitizes BRCA-Proficient TNBC Cells to PARP Inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31040255&form=6&db=m Analysis of DNA Damage Response Gene Alterations and Tumor Mutational Burden Across 17,486 Tubular Gastrointestinal Carcinomas: Implications for Therapy. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31049637&form=6&db=m [Molecular tumor board prostate cancer]. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31050911&form=6&db=m Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31055645&form=6&db=m Novel insights into PARPs in gene expression: regulation of RNA metabolism. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31067289&form=6&db=m Reviewing the characteristics of BRCA and PALB2-related cancers in the precision medicine era. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31069647&form=6&db=m Current Systemic Treatment Landscape of Advanced Gynecologic Malignancies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31070782&form=6&db=m The mechanism of cancer cell death by PARP inhibitors goes beyond DNA damage alone. causal interaction,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31075061&form=6&db=m Biomarkers of drug resistance in ovarian cancer - an update. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31076742&form=6&db=m Universal tumor DNA BRCA1/2 testing of ovarian cancer: prescreening PARPi treatment and genetic predisposition. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31078910&form=6&db=m Structure based pharmacophore study to identify possible natural selective PARP-1 trapper as anti-cancer agent. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31080552&form=6&db=m Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31091037&form=6&db=m [New therapeutic strategies in advanced stage breast and tubo-ovarian cancers]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31092408&form=6&db=m Phosphatase 1 Nuclear Targeting Subunit, a Novel DNA Repair Partner of PARP1. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31092693&form=6&db=m Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31095444&form=6&db=m PARP3 comes to light as a prime target in cancer therapy. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31095896&form=6&db=m Dose-dependent study of effects of 532-nm continuous wave laser on rat skin: A mechanistic insight. causal interaction,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31099622&form=6&db=m Molecular Testing in Breast Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31099635&form=6&db=m The DNA Damaging Revolution: PARP Inhibitors and Beyond. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31102582&form=6&db=m PARPs and PAR as novel pharmacological targets for the treatment of stress granule-associated disorders. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31103013&form=6&db=m A label-free PFP-based photoelectrochemical biosensor for highly sensitive detection of PARP-1 activity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31105872&form=6&db=m Computational analysis of data from a genome-wide screening identifies new PARP1 functional interactors as potential therapeutic targets. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31106005&form=6&db=m Metformin reverses PARP inhibitors-induced epithelial-mesenchymal transition and PD-L1 upregulation in triple-negative breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31108884&form=6&db=m Discovery of 2-(1-(3-(4-Chloroxyphenyl)-3-oxo- propyl)pyrrolidine-3-yl)-1H-benzo[d]imidazole-4-carboxamide: A Potent Poly(ADP-ribose) Polymerase (PARP) Inhibitor for Treatment of Cancer. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31109041&form=6&db=m PARP Inhibitors in Ovarian Cancer: The Route to "Ithaca". causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31125117&form=6&db=m Characterization of transcriptomic signature of primary prostate cancer analogous to prostatic small cell neuroendocrine carcinoma. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31126889&form=6&db=m The BET inhibitor JQ1 attenuates double-strand break repair and sensitizes models of pancreatic ductal adenocarcinoma to PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31127567&form=6&db=m Homologous Recombination-Mediated DNA Repair and Implications for Clinical Treatment of Repair Defective Cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31128995&form=6&db=m Inotodiol inhibits cells migration and invasion and induces apoptosis via p53-dependent pathway in HeLa cells. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31130614&form=6&db=m Immune System and DNA Repair Defects in Ovarian Cancer: Implications for Locoregional Approaches. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31131495&form=6&db=m PARP1 expression in soft tissue sarcomas is a poor-prognosis factor and a new potential therapeutic target. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31133874&form=6&db=m PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31134152&form=6&db=m Nanoformulation of Talazoparib Delays Tumor Progression and Ascites Formation in a Late Stage Cancer Model. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31146482&form=6&db=m PARP Inhibition Increases the Response to Chemotherapy in Uveal Melanoma. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31147264&form=6&db=m Genomic Features of Metastatic Testicular Sex Cord Stromal Tumors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31153806&form=6&db=m Discovery of naphthacemycins as a novel class of PARP1 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31161991&form=6&db=m Recent Study of Dual HDAC/PARP Inhibitor for the Treatment of Tumor. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31182245&form=6&db=m Poly(ADP-Ribosylation) in Age-Related Neurological Disease. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31185206&form=6&db=m Overcoming Treatment Toxicity through Sequential Therapy. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31185210&form=6&db=m Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31186408&form=6&db=m Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31191001&form=6&db=m Current status and future prospects of PARP inhibitor clinical trials in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31194214&form=6&db=m Immune Checkpoint and Poly(ADP-Ribose) Polymerase Inhibition for Recurrent Platinum-Resistant Ovarian and Metastatic Triple-Negative Breast Cancers. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31195178&form=6&db=m Positron-Emission Tomographic Imaging of a Fluorine 18-Radiolabeled Poly(ADP-Ribose) Polymerase 1 Inhibitor Monitors the Therapeutic Efficacy of Talazoparib in SCLC Patient-Derived Xenografts. diagnostic usage,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31196855&form=6&db=m Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31202733&form=6&db=m Therapeutic considerations of PARP in stem cell biology: Relevance in cancer and beyond. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31205507&form=6&db=m Olaparib as maintenance treatment for patients with platinum-sensitive relapsed ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31207286&form=6&db=m Host poly(ADP-ribose) polymerases (PARPs) in acute and chronic bacterial infections. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31216465&form=6&db=m Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31218365&form=6&db=m A decade of clinical development of PARP inhibitors in perspective. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31222709&form=6&db=m Schlafen-11 expression is associated with immune signatures and basal-like phenotype in breast cancer. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31227515&form=6&db=m Sequential Inhibition of PARP and WEE1 Minimizes Toxicity. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31238782&form=6&db=m Radiation-induced synthetic lethality: combination of poly(ADP-ribose) polymerase and RAD51 inhibitors to sensitize cells to proton irradiation. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31242303&form=6&db=m PARP inhibitors for BRCA wild type ovarian cancer; gene alterations, homologous recombination deficiency and combination therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31242618&form=6&db=m Identification of Novel Biomarkers of Homologous Recombination Defect in DNA Repair to Predict Sensitivity of Prostate Cancer Cells to PARP-Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31246122&form=6&db=m In vitro effects of poly(ADP-ribose) polymerase inhibitors on the production of tumor necrosis factor-? by interferon- ? - and lipopolysaccharide-stimulated peripheral blood mononuclear cells of horses. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31250355&form=6&db=m Evaluation of absorption, distribution, metabolism, and excretion of [14C]-rucaparib, a poly(ADP-ribose) polymerase inhibitor, in patients with advanced solid tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31257855&form=6&db=m Quartz Crystal Microbalance Detection of Poly(ADP-ribose) Polymerase-1 Based on Gold Nanorods Signal Amplification. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31258040&form=6&db=m Combination treatment with auranofin and nutlin-3a induces synergistic cytotoxicity in breast cancer cells. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31263571&form=6&db=m High frequency of pathogenic germline variants within homologous recombination repair in patients with advanced cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31266892&form=6&db=m Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31266951&form=6&db=m Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31273204&form=6&db=m Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31273933&form=6&db=m Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31292550&form=6&db=m Tumour lineage shapes BRCA-mediated phenotypes. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31296812&form=6&db=m [Hereditary Breast and Ovarian Cancer Syndrome]. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31299316&form=6&db=m ATM in DNA repair in cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31300704&form=6&db=m Fast dose fractionation using ultra-short laser accelerated proton pulses can increase cancer cell mortality, which relies on functional PARP1 protein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31303961&form=6&db=m PARP-1 inhibitor modulate ?-catenin signaling to enhance cisplatin sensitivity in cancer cervix. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31304797&form=6&db=m Olaparib in germline-mutated metastatic breast cancer: implications of the OlympiAD trial. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31306986&form=6&db=m Risk of fatigue and anemia in patients with advanced cancer treated with olaparib: A meta-analysis of randomized controlled trials. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31309361&form=6&db=m Targeting autophagy potentiates the anti-tumor effect of PARP inhibitor in pediatric chronic myeloid leukemia. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31311167&form=6&db=m Morin Hydrate Reverses Cisplatin Resistance by Impairing PARP1/HMGB1-Dependent Autophagy in Hepatocellular Carcinoma. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31315986&form=6&db=m An Interaction with PARP-1 and Inhibition of Parylation Contribute to Attenuation of DNA Damage Signaling by the Adenovirus E4orf4 Protein. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31316060&form=6&db=m BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31320901&form=6&db=m DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31334122&form=6&db=m Folic Acid Receptor-Mediated Targeting Enhances the Cytotoxicity, Efficacy, and Selectivity of Withania somnifera Leaf Extract: In vitro and in vivo Evidence. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31345267&form=6&db=m A phase I study of the PD-L1 inhibitor, durvalumab, in combination with a PARP inhibitor, olaparib, and a VEGFR1-3 inhibitor, cediranib, in recurrent women's cancers with biomarker analyses. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31351877&form=6&db=m Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31357527&form=6&db=m PARP Inhibitors in Prostate Cancer—The Preclinical Rationale and Current Clinical Development. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31374917&form=6&db=m Combined Strategies with Poly (ADP-Ribose) Polymerase (PARP) Inhibitors for the Treatment of Ovarian Cancer: A Literature Review. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31378459&form=6&db=m Pamiparib in combination with tislelizumab in patients with advanced solid tumours: results from the dose-escalation stage of a multicentre, open-label, phase 1a/b trial. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31391296&form=6&db=m An Analysis of Patients with DNA Repair Pathway Mutations Treated with a PARP Inhibitor. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31394942&form=6&db=m Poly-ADP-ribose polymerases (PARPs) as a therapeutic target in the treatment of selected cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31395352&form=6&db=m Poly-ADP ribosylation in DNA damage response and cancer therapy. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31404966&form=6&db=m Clinical Development of PARP Inhibitors in Treating Metastatic Castration-Resistant Prostate Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31409078&form=6&db=m Breast Cancer in BRCA1/2 Mutation Carriers - Do We Treat It Differently? Focus on Systemic Therapy for BRCA1/2 Associated Breast Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31409613&form=6&db=m The Indenoisoquinoline TOP1 Inhibitors Selectively Target Homologous Recombination-Deficient and Schlafen 11-Positive Cancer Cells and Synergize with Olaparib. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31413177&form=6&db=m PARP1 Inhibition Radiosensitizes Models of Inflammatory Breast Cancer to Ionizing Radiation. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31413734&form=6&db=m PARP1 gene polymorphisms and neuroblastoma susceptibility in Chinese children. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31413820&form=6&db=m Correction: PARP-1 inhibitor modulate ?-catenin signaling to enhance cisplatin sensitivity in cancer cervix. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31416802&form=6&db=m Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31421928&form=6&db=m PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31431131&form=6&db=m Epigallocatechin gallate (EGCG) suppresses growth and tumorigenicity in breast cancer cells by downregulation of miR-25. diagnostic usage,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31443721&form=6&db=m ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31447348&form=6&db=m LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31449760&form=6&db=m Defining and targeting wild-type BRCA high-grade serous ovarian cancer: DNA repair and cell cycle checkpoints. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31451894&form=6&db=m Drug repurposing studies of PARP inhibitors as a new therapy for inherited retinal degeneration. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31456944&form=6&db=m Mechanism of Action and Clinical Efficacy of CDK4/6 Inhibitors in BRCA-Mutated, Estrogen Receptor-Positive Breast Cancers: Case Report and Literature Review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31460099&form=6&db=m Glutathione-Depleting Pro-Oxidant as a Selective Anticancer Therapeutic Agent. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31460501&form=6&db=m Multi gene panel testing for hereditary breast cancer - is it ready to be used? unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31466918&form=6&db=m Molecular mechanisms underlying mifepristone's agonistic action on ovarian cancer progression. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31474062&form=6&db=m [The long coding RNA GSTM3TV2 acts an oncogene to promote chemoresistance in pancreatic cancer]. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31481733&form=6&db=m Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31489639&form=6&db=m Population Pharmacokinetics of Talazoparib in Patients With Advanced Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31508509&form=6&db=m Genome-scale CRISPR knockout screen identifies TIGAR as a modifier of PARP inhibitor sensitivity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31510074&form=6&db=m BRCA2 Deletion Induces Alternative Lengthening of Telomeres in Telomerase Positive Colon Cancer Cells. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31511432&form=6&db=m Wnt/?-catenin signaling as a useful therapeutic target in hepatoblastoma. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31512029&form=6&db=m Prexasertib, a checkpoint kinase inhibitor: from preclinical data to clinical development. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31515456&form=6&db=m Transcriptomic heterogeneity of androgen receptor (AR) activity defines a de novo low AR-active subclass in treatment naïve primary prostate cancer. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31523195&form=6&db=m BRD4 Inhibitor AZD5153 Suppresses the Proliferation of Colorectal Cancer Cells and Sensitizes the Anticancer Effect of PARP Inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31527467&form=6&db=m Cytotoxicity and Differentiating Effect of the Poly(ADP-Ribose) Polymerase Inhibitor Olaparib in Myelodysplastic Syndromes. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31529615&form=6&db=m Premature mitotic entry induced by ATR inhibition potentiates olaparib inhibition-mediated genomic instability, inflammatory signaling and cytotoxicity in BRCA2-deficient cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31534547&form=6&db=m A nano-liposome formulation of the PARP inhibitor Talazoparib enhances treatment efficacy and modulates immune cell populations in mammary tumors of BRCA-deficient mice. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31537627&form=6&db=m Next-generation sequencing-based BRCA testing on cytological specimens from ovarian cancer ascites reveals high concordance with tumour tissue analysis. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31549216&form=6&db=m Phase 1 study of veliparib (ABT-888), a poly (ADP-ribose) polymerase inhibitor, with carboplatin and paclitaxel in advanced solid malignancies. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31551715&form=6&db=m Poly (ADP-Ribose) Polymerase-1 (PARP1) Deficiency and Pharmacological Inhibition by Pirenzepine Protects From Cisplatin-Induced Ototoxicity Without Affecting Antitumor Efficacy. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31565603&form=6&db=m Molecular Testing Identifies Determinants of Exceptional Response and Guides Precision Therapy in a Patient with Lethal, Treatment-emergent Neuroendocrine Prostate Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31577852&form=6&db=m Longitudinal analysis of a secondary BRCA2 mutation using digital droplet PCR. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31591209&form=6&db=m DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31592410&form=6&db=m Therapeutic Targeting of MZF1-AS1/PARP1/E2F1 Axis Inhibits Proline Synthesis and Neuroblastoma Progression. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31594824&form=6&db=m ADP-Ribosylation Levels and Patterns Correlate with Gene Expression and Clinical Outcomes in Ovarian Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31597711&form=6&db=m Synergism between ATM and PARP1 Inhibition Involves DNA Damage and Abrogating the G2 DNA Damage Checkpoint. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31605774&form=6&db=m The combination of BET and PARP inhibitors is synergistic in models of cholangiocarcinoma. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31609976&form=6&db=m Modulation of brain tumor risk by genetic SNPs in PARP1gene: Hospital based case control study. causal interaction,ongoing research,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31614656&form=6&db=m PARP1 Co-Regulates EP300-BRG1-Dependent Transcription of Genes Involved in Breast Cancer Cell Proliferation and DNA Repair. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31615159&form=6&db=m RAD52 as a Potential Target for Synthetic Lethality-Based Anticancer Therapies. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31619547&form=6&db=m Treatment of Pediatric Glioblastoma with Combination Olaparib and Temozolomide Demonstrates 2-Year Durable Response. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31625002&form=6&db=m PARP Inhibition in Cancer: An Update on Clinical Development. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31627702&form=6&db=m Synthetic Lethality - Its Current Application and Potential in Oncological Treatment. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31629931&form=6&db=m Three-dimensional oxabicycloheptene sulfonate targets the homologous recombination and repair programmes through estrogen receptor ? antagonism. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31641851&form=6&db=m Apoptosis induction in lung and prostate cancer cells through silver nanoparticles synthesized from Pinus roxburghii bioactive fraction. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31650446&form=6&db=m Veliparib in ovarian cancer: a new synthetically lethal therapeutic approach. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31653094&form=6&db=m Tumor BRCA Test for Patients with Epithelial Ovarian Cancer: The Role of Molecular Pathology in the Era of PARP Inhibitor Therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31659317&form=6&db=m Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31676541&form=6&db=m ATM Dysfunction in Pancreatic Adenocarcinoma and Associated Therapeutic Implications. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31676714&form=6&db=m Metastatic Thymoma Harboring a Deleterious BRCA2 Mutation Derives Durable Clinical Benefit from Olaparib. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31676982&form=6&db=m Imatinib modulates pro-inflammatory microenvironment with angiostatic effects in experimental lung carcinogenesis. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31679579&form=6&db=m High specificity and efficiency electrochemical detection of poly(ADP-ribose) polymerase-1 activity based on versatile peptide-templated copper nanoparticles and detection array. diagnostic usage,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31686145&form=6&db=m Autophagy suppression enhances DNA damage and cell death upon treatment with PARP inhibitor Niraparib in laryngeal squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31695491&form=6&db=m TCDD-Inducible Poly-ADP-Ribose Polymerase (TIPARP), A Novel Therapeutic Target Of Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31714594&form=6&db=m Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts, and patient-derived xenograft models. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31715127&form=6&db=m Induction of BRCAness in Triple-Negative Breast Cancer by a CDK12/13 Inhibitor Improves Chemotherapy. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31724813&form=6&db=m Phase 1/2 trial of talazoparib in combination with temozolomide in children and adolescents with refractory/recurrent solid tumors including Ewing sarcoma: A Children's Oncology Group Phase 1 Consortium study (ADVL1411). ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31727767&form=6&db=m ATR addiction in multiple myeloma: synthetic lethal approaches exploiting established therapies. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31737426&form=6&db=m Advances and perspectives of PARP inhibitors. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31738050&form=6&db=m Synthesis, Cytotoxicity, and Mechanistic Investigation of Platinum(IV) Anticancer Complexes Conjugated with Poly(ADP-ribose) Polymerase Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31752145&form=6&db=m Curcumin Nicotinate Selectively Induces Cancer Cell Apoptosis and Cycle Arrest through a P53-Mediated Mechanism. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31753490&form=6&db=m Non-small cell lung cancer cells with deficiencies in homologous recombination genes are sensitive to PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31756364&form=6&db=m Delving into PARP inhibition from bench to bedside and back. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31757307&form=6&db=m Personalized Medicine in Gynecologic Cancer: Fact or Fiction? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31766720&form=6&db=m Structure-Based Pharmacophore Modeling, Virtual Screening, Molecular Docking and Biological Evaluation for Identification of Potential Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31771620&form=6&db=m Pharmacogenomic analysis of patient-derived tumor cells in gynecologic cancers. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31772676&form=6&db=m Liensinine inhibited gastric cancer cell growth through ROS generation and the PI3K/AKT pathway. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31773025&form=6&db=m Combined Treatment Modalities for High-Energy Proton Irradiation: Exploiting Specific DNA Repair Dependencies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31776133&form=6&db=m Gain-of-Function Mutant p53 R273H Interacts with Replicating DNA and PARP1 in Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31783569&form=6&db=m IL-24 Inhibits Lung Cancer Growth by Suppressing GLI1 and Inducing DNA Damage. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31783714&form=6&db=m Investigational CHK1 inhibitors in early phase clinical trials for the treatment of cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31786739&form=6&db=m Fluzoparib increases radiation sensitivity of non-small cell lung cancer (NSCLC) cells without BRCA1/2 mutation, a novel PARP1 inhibitor undergoing clinical trials. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31787769&form=6&db=m Experiencia con el uso de olaparib en pacientes con cáncer de ovario. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31800149&form=6&db=m Simultaneous measurement of perillyl alcohol and its metabolite perillic acid in plasma and lung after inhalational administration in Wistar rats. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31807308&form=6&db=m Cancer biomarkers for targeted therapy. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31812083&form=6&db=m Silencing of CHFR Sensitizes Gastric Carcinoma to PARP Inhibitor Treatment. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31813938&form=6&db=m Results of a phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA-defective tumours. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31815045&form=6&db=m Disulfiram combined with copper induces immunosuppression via PD-L1 stabilization in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31815769&form=6&db=m Mechanisms of PARP inhibitor resistance in ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31816985&form=6&db=m The Anti-Proliferative Activity of the Hybrid TMS-TMF-4f Compound Against Human Cervical Cancer Involves Apoptosis Mediated by STAT3 Inactivation. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31827085&form=6&db=m Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31831554&form=6&db=m A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31846325&form=6&db=m Discovery of Novel Dual Poly(ADP-ribose)polymerase and Phosphoinositide 3-Kinase Inhibitors as a Promising Strategy for Cancer Therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31846530&form=6&db=m Targeted therapies in gynaecological cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31850224&form=6&db=m The Phytosterol Peniocerol Inhibits Cell Proliferation and Tumor Growth in a Colon Cancer Xenograft Model. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31852834&form=6&db=m EGFR Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31855806&form=6&db=m PARP-1 expression as a prognostic factor in Desmoid-type fibromatosis. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31856867&form=6&db=m Mortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31861350&form=6&db=m PARP1 Inhibition Augments UVB-Mediated Mitochondrial Changes-Implications for UV-Induced DNA Repair and Photocarcinogenesis. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31865042&form=6&db=m Circulating HOXA9-methylated tumour DNA: A novel biomarker of response to poly (ADP-ribose) polymerase inhibition in BRCA-mutated epithelial ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31877876&form=6&db=m Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31896689&form=6&db=m 53BP1: a DSB escort. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31898156&form=6&db=m DNA damage repair functions and targeted treatment in breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31900275&form=6&db=m Restoration of Temozolomide Sensitivity by PARP Inhibitors in Mismatch Repair Deficient Glioblastoma is Independent of Base Excision Repair. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31900907&form=6&db=m Prostate Cancer Transcriptomic Subtypes. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31903985&form=6&db=m ERCC1, PARP-1, and AQP1 as predictive biomarkers in colon cancer patients receiving adjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31906887&form=6&db=m Loss of the SWI/SNF-ATPase subunit members SMARCF1 (ARID1A), SMARCA2 (BRM), SMARCA4 (BRG1) and SMARCB1 (INI1) in oesophageal adenocarcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31907114&form=6&db=m Verapamil enhances the sensitivity of oxaliplatin to tumor cells by influencing the PARP pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31912897&form=6&db=m Targeting cervical cancer: Is there a role for poly (ADP-ribose) polymerase inhibition? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31914341&form=6&db=m Gamma ray-induced in vitro cell migration via EGFR/ERK/Akt/p38 activation is prevented by olaparib pretreatment. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31915374&form=6&db=m TRIP13 regulates DNA repair pathway choice through REV7 conformational change. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31921645&form=6&db=m Harnessing DNA Double-Strand Break Repair for Cancer Treatment. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31930280&form=6&db=m ADP-ribosylation: from molecular mechanisms to human disease. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31931287&form=6&db=m Mechanism and current progress of Poly ADP-ribose polymerase (PARP) inhibitors in the treatment of ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31932422&form=6&db=m Trop2 is a driver of metastatic prostate cancer with neuroendocrine phenotype via PARP1. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31944123&form=6&db=m Disulfide Cleavage in a Dimeric Epipolythiodioxopiperazine Natural Product Diminishes Its Apoptosis-Inducing Effect but Enhances Autophagy in Tumor Cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31954719&form=6&db=m OSU-A9 induced-reactive oxygen species cause cytotoxicity in duodenal and gastric cancer cells by decreasing phosphorylated nuclear pyruvate kinase M2 protein levels. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31958182&form=6&db=m Using next-generation sequencing to redefine BRCAness in triple-negative breast cancer. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31962202&form=6&db=m Design, synthesis and biological evaluation of erythrina derivatives bearing a 1,2,3-triazole moiety as PARP-1 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31967513&form=6&db=m PARP inhibitors: a tsunami of indications in different malignancies. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31989039&form=6&db=m CRISPR/Cas9-mediated mutagenesis to validate the synergy between PARP1 inhibition and chemotherapy in BRCA1-mutated breast cancer cells. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31993510&form=6&db=m Phase I study of the PARP inhibitor talazoparib with radiation therapy for locally recurrent gynecologic cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32001817&form=6&db=m Coordinated signals from PARP-1 and PARP-2 are required to establish a proper T cell immune response to breast tumors in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32003046&form=6&db=m PARP1 V762A polymorphism affects the prognosis of myelodysplastic syndromes. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32005245&form=6&db=m Mutations of BRCA2 in canine mammary tumors and their targeting potential in clinical therapy. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32010441&form=6&db=m Targeting dePARylation for cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32010626&form=6&db=m The Interplay Between the DNA Damage Response, RNA Processing and Extracellular Vesicles. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32017532&form=6&db=m Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32018126&form=6&db=m Magnitude of benefit of the addition of poly ADP-ribose polymerase (PARP) inhibitors to therapy for malignant tumor: A meta-analysis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32019870&form=6&db=m Thermal proteome profiling identifies oxidative-dependent inhibition of the transcription of major oncogenes as a new therapeutic mechanism for select anticancer compounds. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32023457&form=6&db=m A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32028808&form=6&db=m A profile on the FoundationFocus CDxBRCA tests. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32029455&form=6&db=m PARP and PARG inhibitors in cancer treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32029902&form=6&db=m Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32030362&form=6&db=m PARP Inhibitors in Pancreatic Cancer: From Phase I to Plenary Session. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32036006&form=6&db=m Combination Therapy with Radiation and PARP Inhibition Enhances Responsiveness to Anti-PD-1 Therapy in Colorectal Tumor Models. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32040686&form=6&db=m The implications of BRCA loss of heterozygosity (LOH) and deficient mismatch repair gene (dMMR) expression in the breast cancer of a patient with both inherited breast and ovarian cancer syndrome (BRCA2) and Lynch syndrome (MLH1). therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32041954&form=6&db=m PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32046278&form=6&db=m Immunomodulatory Roles of PARP-1 and PARP-2: Impact on PARP-Centered Cancer Therapies. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32046300&form=6&db=m PARP Inhibitors as Therapeutics: Beyond Modulation of PARylation. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32048546&form=6&db=m Identifying new piperazine-based PARP1 inhibitors using text mining and integrated molecular modeling approaches. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32048968&form=6&db=m Anticancer agents based on vulnerable components in a signalling pathway. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32049041&form=6&db=m Opening a Door to PARP Inhibitor-Induced Lethality in HR-Proficient Human Tumor Cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32053991&form=6&db=m Establishment and Characterization of a Brca1-/-, p53-/- Mouse Mammary Tumor Cell Line. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32055930&form=6&db=m Phase I and pharmacokinetic study of veliparib, a PARP inhibitor, and pegylated liposomal doxorubicin (PLD) in recurrent gynecologic cancer and triple negative breast cancer with long-term follow-up. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32059481&form=6&db=m Identification of PARP-1, Histone H1 and SIRT-1 as New Regulators of Breast Cancer-Related Aromatase Promoter I.3/II. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32060423&form=6&db=m PLK1/NF-?B feedforward circuit antagonizes the mono-ADP-ribosyltransferase activity of PARP10 and facilitates HCC progression. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32061304&form=6&db=m Therapeutic Application of PARP Inhibitors in Neuro-Oncology. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32066626&form=6&db=m Targeted brain tumor radiotherapy using an Auger emitter. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32066627&form=6&db=m Targeting DNA repair to drive immune responses: it's time to reconsider the strategy for clinical translation. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32066817&form=6&db=m The kinase polypharmacology landscape of clinical PARP inhibitors. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32067102&form=6&db=m PARP Inhibitors in Gynecologic Cancers: What Is the Next Big Development? causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32071145&form=6&db=m Transcription-Associated Cyclin-Dependent Kinases as Targets and Biomarkers for Cancer Therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32073931&form=6&db=m Targeting DNA damage response in head and neck cancers through abrogation of cell cycle checkpoints. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32075397&form=6&db=m Biliary tract cancer and genomic alterations in homologous recombinant deficiency: exploiting synthetic lethality with PARP inhibitors. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32079521&form=6&db=m Modeling of the Enzyme-Substrate Complexes of Human Poly(ADP-Ribose) Polymerase 1. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32081041&form=6&db=m Investigation of U-251 cell death triggered by flavonoid luteolin: towards a better understanding on its anticancer property against glioblastomas. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32088129&form=6&db=m Design, synthesis and anticancer activities of novel dual poly(ADP-ribose) polymerase-1/histone deacetylase-1 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32093123&form=6&db=m Synergistic Anti-Tumour Effect of Syk Inhibitor and Olaparib in Squamous Cell Carcinoma: Roles of Syk in EGFR Signalling and PARP1 Activation. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32094664&form=6&db=m The antitumorigenic roles of BRCA1-BARD1 in DNA repair and replication. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32106627&form=6&db=m Role of Akt Activation in PARP Inhibitor Resistance in Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32107968&form=6&db=m Understanding the mechanism of amygdalin's multifunctional anti-cancer action using computational approach. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32111912&form=6&db=m Genomic alterations and abnormal expression of APE2 in multiple cancers. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32117762&form=6&db=m PARP Inhibitors in Prostate and Urothelial Cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32117774&form=6&db=m Combination Therapy With Charged Particles and Molecular Targeting: A Promising Avenue to Overcome Radioresistance. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32122376&form=6&db=m PARP inhibitors in pancreatic cancer: molecular mechanisms and clinical applications. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32122513&form=6&db=m A dermatan sulfate-functionalized biomimetic nanocarrier for melanoma targeted chemotherapy. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32124385&form=6&db=m Somatic mRNA Analysis of BRCA1 Splice Variants Provides a Direct Theranostic Impact on PARP Inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32127357&form=6&db=m ATM Loss Confers Greater Sensitivity to ATR Inhibition than PARP Inhibition in Prostate Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32135515&form=6&db=m Exceptional Response to Olaparib in a Patient With Recurrent Ovarian Cancer and an Entire BRCA1 Germline Gene Deletion. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32135972&form=6&db=m Risk of selected gastrointestinal and hepatic toxicities in cancer patients treated with PARP inhibitors: A systematic review and meta-analysis. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32150979&form=6&db=m KCP10043F Represses the Proliferation of Human Non-Small Cell Lung Cancer Cells by Caspase-Mediated Apoptosis via STAT3 Inactivation. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32151005&form=6&db=m The Controversial Roles of ADP-Ribosyl Hydrolases MACROD1, MACROD2 and TARG1 in Carcinogenesis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32164505&form=6&db=m A Review on Poly (ADP-ribose) Polymerase (PARP) Inhibitors and Synthetic Methodologies. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32165735&form=6&db=m Validation of the use of a fluorescent PARP1 inhibitor for the detection of oral, oropharyngeal and oesophageal epithelial cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32165926&form=6&db=m How and when to refer patients for oncogenetic counseling in the era of PARP inhibitors. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32171145&form=6&db=m Low-dose naltrexone inhibits colorectal cancer progression and promotes apoptosis by increasing M1-type macrophages and activating the Bax/Bcl-2/caspase-3/PARP pathway. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32171277&form=6&db=m Polyclonal BRCA2 mutations following carboplatin treatment confer resistance to the PARP inhibitor rucaparib in a patient with mCRPC: a case report. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32172572&form=6&db=m Niraparib for the Treatment of Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32172801&form=6&db=m Targets for Therapy of Bladder Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32177661&form=6&db=m PARP inhibitor (PARPi) monotherapy treatment in non-BRCA and/or non-serous gynaecological cancers. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32180937&form=6&db=m The role of poly(ADP-ribose) polymerase inhibitors in the treatment of cancer and methods to overcome resistance: a review. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32181758&form=6&db=m [Medical treatment options in BRCA-associated cancers]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32183301&form=6&db=m ATM-Deficient Cancers Provide New Opportunities for Precision Oncology. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32183851&form=6&db=m Tumor burden is a potential marker of PARP inhibitor effects in ovarian cancer: a head-to-head observational series. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32193285&form=6&db=m Inactivation of the prolyl isomerase Pin1 sensitizes BRCA1-proficient breast cancer to PARP inhibition. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32194409&form=6&db=m Poly(ADP-Ribose)Polymerase (PARP) Inhibitors and Radiation Therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32194909&form=6&db=m Acquired multiple secondary BRCA2 mutations upon PARPi resistance in a metastatic pancreatic cancer patient harboring a BRCA2 germline mutation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32198459&form=6&db=m A critical evaluation of methods to interpret drug combinations. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32200419&form=6&db=m Ovarian cancer stem cells: ready for prime time? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32200503&form=6&db=m CUDC-907 enhances TRAIL-induced apoptosis through upregulation of DR5 in breast cancer cells. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32207233&form=6&db=m Molecular natural history of breast cancer: Leveraging transcriptomics to predict breast cancer progression and aggressiveness. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32208631&form=6&db=m Single-Particle Assay of Poly(ADP-ribose) Polymerase-1 Activity with Dark-Field Optical Microscopy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32215876&form=6&db=m Poly (ADP-Ribose) Polymerase Inhibitors: Talazoparib in Ovarian Cancer and Beyond. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32221289&form=6&db=m Differential regulation of breast cancer bone metastasis by PARP1 and PARP2. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32222339&form=6&db=m Synthesis of novel dual target inhibitors of PARP and HSP90 and their antitumor activities. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32223193&form=6&db=m Daphnane Diterpenoids from Daphne genkwa Inhibit PI3K/Akt/mTOR Signaling and Induce Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32235451&form=6&db=m Response of Breast Cancer Cells to PARP Inhibitors Is Independent of BRCA Status. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32241645&form=6&db=m [Hereditary breast carcinomas pathologist's perspective]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32241924&form=6&db=m Structural basis for allosteric PARP-1 retention on DNA breaks. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32245040&form=6&db=m The Multifactorial Role of PARP-1 in Tumor Microenvironment. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32249776&form=6&db=m Pan-cancer analysis reveals synergistic effects of CDK4/6i and PARPi combination treatment in RB-proficient and RB-deficient breast cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32262043&form=6&db=m Systemic delivery of axitinib with nanohybrid liposomal nanoparticles inhibits hypoxic tumor growth. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32265228&form=6&db=m Verteporfin Inhibits PD-L1 through Autophagy and the STAT1-IRF1-TRIM28 Signaling Axis, Exerting Antitumor Efficacy. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32265701&form=6&db=m Antitumor Effects and the Compatibility Mechanisms of Herb Pair Scleromitrion diffusum (Willd.) R. J. Wang-Sculellaria barbata D. Don. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32268868&form=6&db=m In silico discovery of novel flavonoids as poly ADP ribose polymerase (PARP) inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32272732&form=6&db=m Ovarian Cancer Translational Activity of the Multicenter Italian Trial in Ovarian Cancer (MITO) Group: Lessons Learned in 10 Years of Experience. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32279088&form=6&db=m Olaparib and temozolomide in desmoplastic small round cell tumors: a promising combination in vitro and in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32282108&form=6&db=m Olaparib-Based Photoaffinity Probes for PARP-1 Detection in Living Cells. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32286930&form=6&db=m Preserving genome integrity in human cells via DNA double-strand break repair. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32295316&form=6&db=m Therapeutic Strategies and Biomarkers to Modulate PARP Activity for Targeted Cancer Therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32297440&form=6&db=m Metastatic Thymoma Harboring a Deleterious BRCA2 Mutation Derives Durable Clinical Benefit from Olaparib. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32298799&form=6&db=m Combination of photoactive hypericin and Manumycin A exerts multiple anticancer effects on oxaliplatin-resistant colorectal cells. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32315385&form=6&db=m ShallowHRD: detection of homologous recombination deficiency from shallow whole genome sequencing. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32316192&form=6&db=m Mitochondrial Protection by PARP Inhibition. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32316968&form=6&db=m Participation of the ATR/CHK1 pathway in replicative stress targeted therapy of high-grade ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32329510&form=6&db=m Role of PARP1 regulation in radiation-induced rescue effect. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32344512&form=6&db=m The Cytotoxic and Apoptotic Effects of the Brown Algae Colpomenia sinuosa are Mediated by the Generation of Reactive Oxygen Species. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32352035&form=6&db=m A single nucleotide variant of human PARP1 determines response to PARP inhibitors. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32352724&form=6&db=m Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32357296&form=6&db=m Probing the Conformational Changes Associated with DNA Binding to PARP1. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32364757&form=6&db=m PARP Inhibitors for Ovarian Cancer: Current Indications, Future Combinations, and Novel Assets in Development to Target DNA Damage Repair. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32371137&form=6&db=m 'PARP'ing fibrosis: repurposing poly (ADP ribose) polymerase (PARP) inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32378669&form=6&db=m [Learning from My Experience: Outpatient Care for Cancer Multigene Genomic Testing]. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32379297&form=6&db=m Systems approach to rational combination therapy: PARP inhibitors. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32380691&form=6&db=m Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,2 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32392194&form=6&db=m [PARP10 Influences the Proliferation of Colorectal Carcinoma Cells, a Preliminary Study]. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32394702&form=6&db=m Novel Poly(ADP-ribose) Polymerase-1 Inhibitor DDHCB Inhibits Proliferation of BRCA Mutant Breast Cancer Cell In Vitro and In Vivo through a Synthetic Lethal Mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32400970&form=6&db=m Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32401642&form=6&db=m Autophagy in the physiological endometrium and cancer. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32402770&form=6&db=m Histone-dependent PARP-1 inhibitors: A novel therapeutic modality for the treatment of prostate and renal cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32405340&form=6&db=m Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32412821&form=6&db=m Kaempferol Protects Against Hydrogen Peroxide-Induced Retinal Pigment Epithelium Cell Inflammation and Apoptosis by Activation of SIRT1 and Inhibition of PARP1. diagnostic usage,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32415868&form=6&db=m Biasing human epidermal growth factor receptor 4 (HER4) tyrosine kinase signaling with antibodies: Induction of cell death by antibody-dependent HER4 intracellular domain trafficking. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32418525&form=6&db=m Targeting Different Pathways Using Novel Combination Therapy in Triple Negative Breast Cancer. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32427631&form=6&db=m Poly(ADP-ribose) polymerase inhibitors in prostate and urothelial cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32431354&form=6&db=m Characterization and anti-tumor activity of saponin-rich fractions of South Korean sea cucumbers (Apostichopus japonicus). therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32434918&form=6&db=m Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32436762&form=6&db=m Assessment of PARP-1 Distribution in Tissues of Cynomolgus Monkeys. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32444694&form=6&db=m Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32450190&form=6&db=m PARP inhibition in the ovarian cancer patient: Current approvals and future directions. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32451414&form=6&db=m Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32455851&form=6&db=m Transcriptional Regulation of CCL2 by PARP1 Is a Driver for Invasiveness in Breast Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32457830&form=6&db=m Therapeutic Potential of Combining PARP Inhibitor and Immunotherapy in Solid Tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32459988&form=6&db=m Biomarker-Guided Development of DNA Repair Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32460015&form=6&db=m Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32468256&form=6&db=m High resolution melting profiles (HRMPs) obtained by magnetic induction cycler (MIC) have been used to monitor the BRCA2 status highlighted by next generation tumor sequencing (NGTS): a combined approach in a diagnostic environment. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32475473&form=6&db=m Pharmacological methods to transcriptionally modulate double-strand break DNA repair. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32486514&form=6&db=m BAX Redistribution Induces Apoptosis Resistance and Selective Stress Sensitivity in Human HCC. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32487588&form=6&db=m Moving beyond PARP Inhibition in ATM-Deficient Prostate Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32493233&form=6&db=m Similar response rates and survival with PARP inhibitors for patients with solid tumors harboring somatic versus Germline BRCA mutations: a Meta-analysis and systematic review. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32497971&form=6&db=m PARP and PD-1/PD-L1 checkpoint inhibition in recurrent or metastatic endometrial cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32498352&form=6&db=m Current Strategies and Novel Therapeutic Approaches for Metastatic Urothelial Carcinoma. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32503981&form=6&db=m m5C modification of mRNA serves a DNA damage code to promote homologous recombination. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32505664&form=6&db=m Pharmacological targets and molecular mechanisms of plumbagin to treat colorectal cancer: A systematic pharmacology study. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32526888&form=6&db=m Combined PARP Inhibition and Immune Checkpoint Therapy in Solid Tumors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32526907&form=6&db=m Identifying and Overcoming Mechanisms of PARP Inhibitor Resistance in Homologous Recombination Repair-Deficient and Repair-Proficient High Grade Serous Ovarian Cancer Cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32532747&form=6&db=m Phase I Trial of the PARP Inhibitor Olaparib and AKT Inhibitor Capivasertib in Patients with BRCA1/2- and Non-BRCA1/2-Mutant Cancers. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32546832&form=6&db=m Differential therapeutic effects of PARP and ATR inhibition combined with radiotherapy in the treatment of subcutaneous versus orthotopic lung tumour models. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32560564&form=6&db=m Overcoming Platinum and PARP-Inhibitor Resistance in Ovarian Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32563252&form=6&db=m PARP inhibitor resistance: the underlying mechanisms and clinical implications. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32563561&form=6&db=m The evolving management of metastatic triple negative breast cancer. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32568634&form=6&db=m Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors. diagnostic usage,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32569489&form=6&db=m Emerging drugs for the treatment of ovarian cancer: a focused review of PARP inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32571788&form=6&db=m Identification of Somatically Acquired BRCA1/2 Mutations by cfDNA Analysis in Patients with Metastatic Breast Cancer. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32572188&form=6&db=m Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32575437&form=6&db=m The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32576907&form=6&db=m Enhancing the anti-tumour activity of 177Lu-DOTA-octreotate radionuclide therapy in somatostatin receptor-2 expressing tumour models by targeting PARP. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32577161&form=6&db=m MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32579791&form=6&db=m Crossroads of telomere biology and anticancer drug discovery. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32586104&form=6&db=m Vitamin C and Cell Death. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32597301&form=6&db=m Poly-(ADP-ribose) polymerase inhibitors: paradigm shift in the first-line treatment of newly diagnosed advanced ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32601814&form=6&db=m Targeting DNA Damage Repair Pathways in Pancreatic Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32604417&form=6&db=m The PARP inhibitor, olaparib, depletes the ovarian reserve in mice: implications for fertility preservation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32633033&form=6&db=m Medical Management of newly diagnosed breast cancer in a BRCA1/2 mutation carrier. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32640701&form=6&db=m The Nucleolus and PARP1 in Cancer Biology. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32640708&form=6&db=m Advancements in PARP1 Targeted Nuclear Imaging and Theranostic Probes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32644177&form=6&db=m Further Analyses Highlight Benefits of PARP Inhibitors As Frontline Maintenance in Ovarian Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32651270&form=6&db=m Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32652442&form=6&db=m Pamiparib is a potent and selective PARP inhibitor with unique potential for the treatment of brain tumor. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32653610&form=6&db=m Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole scaffold: Novel potential CDK9 inhibitors. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32657779&form=6&db=m Genomic landscape of metastatic breast cancer identifies preferentially dysregulated pathways and targets. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32668240&form=6&db=m Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32669350&form=6&db=m A Novel Mechanism to Induce BRCAness in Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32679669&form=6&db=m The Landscape and Therapeutic Implications of Molecular Profiles in Epithelial Ovarian Cancer. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32686903&form=6&db=m Inhibition of c-MET increases the antitumour activity of PARP inhibitors in gastric cancer models. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32694901&form=6&db=m Phase I dose-escalation and expansion study of PARP inhibitor, fluzoparib (SHR3162), in patients with advanced solid tumors. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32711558&form=6&db=m MAPK4 deletion enhances radiation effects and triggers synergistic lethality with simultaneous PARP1 inhibition in cervical cancer. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32717529&form=6&db=m The ups and downs of Poly(ADP-ribose) Polymerase-1 inhibitors in cancer therapy-Current progress and future direction. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32722408&form=6&db=m PARP Inhibitor Resistance Mechanisms and Implications for Post-Progression Combination Therapies. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32727929&form=6&db=m Evaluation of PARP and PDL-1 as potential therapeutic targets for women with high-grade neuroendocrine carcinomas of the cervix. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32728057&form=6&db=m Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32728620&form=6&db=m Olaparib for metastatic breast cancer in a patient with a germline PALB2 variant. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32747362&form=6&db=m BRCA1 Mutations in Cancer: Coordinating Deficiencies in Homologous Recombination with Tumorigenesis. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32755579&form=6&db=m The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32757789&form=6&db=m Combination therapy in advanced urothelial cancer: the role of PARP, HER-2 and mTOR inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32759682&form=6&db=m Brain Metastases from Ovarian Cancer: Current Evidence in Diagnosis, Treatment, and Prognosis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32763225&form=6&db=m Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32768729&form=6&db=m Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32774407&form=6&db=m Anticancer Effect of Mountain Ginseng on Human Breast Cancer: Comparison with Farm-Cultivated Ginseng. causal interaction,ongoing research,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32776008&form=6&db=m XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32778095&form=6&db=m Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32779949&form=6&db=m Identification of probe-quality degraders for Poly(ADP-ribose) polymerase-1 (PARP-1). causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32782491&form=6&db=m PARP inhibition and immune modulation: scientific rationale and perspectives for the treatment of gynecologic cancers. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32783940&form=6&db=m FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32790034&form=6&db=m PARP Inhibitors and Prostate Cancer: To Infinity and Beyond BRCA. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32790492&form=6&db=m PARP Inhibitors in the Management of Ovarian Cancer: ASCO Guideline. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32796232&form=6&db=m Role of Poly (ADP-Ribose) Polymerase inhibitors beyond BReast CAncer Gene-mutated ovarian tumours: definition of homologous recombination deficiency? causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32799124&form=6&db=m Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32801862&form=6&db=m PARP Inhibitors in Endometrial Cancer: Current Status and Perspectives. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32811446&form=6&db=m PARP inhibitors combined with ionizing radiation induce different effects in melanoma cells and healthy fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32812709&form=6&db=m Combining PARP Inhibition with Platinum, Ruthenium or Gold Complexes for Cancer Therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32814685&form=6&db=m When and How to Use PARP Inhibitors in Prostate Cancer: A Systematic Review of the Literature with an Update on On-Going Trials. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32814805&form=6&db=m Segregation analysis of the BRCA2 c.9227G>T variant in multiple families suggests a pathogenic role in breast and ovarian cancer predisposition. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32817374&form=6&db=m Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32819110&form=6&db=m PARP inhibitors in ovarian cancer: evidence for maintenance and treatment strategies. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32822082&form=6&db=m MicroRNA216b mediated downregulation of HSP27/STAT3/AKT signaling is critically involved in lambertianic acid induced apoptosis in human cervical cancers. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32825706&form=6&db=m Novel Caffeic Acid Phenethyl Ester-Mortalin Antibody Nanoparticles Offer Enhanced Selective Cytotoxicity to Cancer Cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32832608&form=6&db=m TIP60 K430 SUMOylation attenuates its interaction with DNA-PKcs in S-phase cells: Facilitating homologous recombination and emerging target for cancer therapy. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32844745&form=6&db=m PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32846126&form=6&db=m Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32848424&form=6&db=m Metastatic Castration-Resistant Prostate Cancer with Neuroendocrine Transformation and BRCA 1 Germ-Line Mutation: A Case Report and Literature Review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32850156&form=6&db=m Poly (ADP-Ribose) Polymerase 1 Protein Expression in Normal Pancreas and Pancreatic Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32852311&form=6&db=m Combining poly(ADP-ribose) polymerase inhibitors and immune checkpoint inhibitors in breast cancer: rationale and preliminary clinical results. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32852746&form=6&db=m Movement of Poly-ADP Ribose (PARP) Inhibition into Frontline Treatment of Ovarian Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32856869&form=6&db=m Prevalence of Tissue BRCA Gene Mutation in Ovarian, Fallopian Tube, and Primary Peritoneal Cancers: A Multi-Institutional Study. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32859985&form=6&db=m XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32861273&form=6&db=m Veliparib with carboplatin and paclitaxel in BRCA-mutated advanced breast cancer (BROCADE3): a randomised, double-blind, placebo-controlled, phase 3 trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,2 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32865667&form=6&db=m Wikstromol from Wikstroemia indica induces apoptosis and suppresses migration of MDA-MB-231 cells via inhibiting PI3K/Akt pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32872253&form=6&db=m Development of a Cationic Amphiphilic Helical Peptidomimetic (B18L) As A Novel Anti-Cancer Drug Lead. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32872764&form=6&db=m Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32877777&form=6&db=m BAP1: Not just a BRCA1-associated protein. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32878011&form=6&db=m PARP Inhibitors in Biliary Tract Cancer: A New Kid on the Block? therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32884152&form=6&db=m Poly(ADP-ribose) polymerase inhibition: past, present and future. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32884343&form=6&db=m NEAT1 Knockdown Suppresses the Cisplatin Resistance in Ovarian Cancer by Regulating miR-770-5p/PARP1 Axis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32900500&form=6&db=m Comparing mutation frequencies for homologous recombination genes in uterine serous and high-grade serous ovarian carcinomas: A case for homologous recombination deficiency testing in uterine serous carcinoma. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32903788&form=6&db=m Pan-Cancer Analysis of BRCA1 and BRCA2 Genomic Alterations and Their Association With Genomic Instability as Measured by Genome-Wide Loss of Heterozygosity. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32905466&form=6&db=m AMXI-5001, a novel dual parp1/2 and microtubule polymerization inhibitor for the treatment of human cancers. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32912765&form=6&db=m Management of early breast cancer in patients bearing germline BRCA mutations. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32916798&form=6&db=m The Treatment of Heterotopic Human Colon Xenograft Tumors in Mice with 5-Fluorouracil Attached to Magnetic Nanoparticles in Combination with Magnetic Hyperthermia Is More Efficient than Either Therapy Alone. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32917522&form=6&db=m A Prospective Phase II Single-arm Study of Niraparib Plus Dostarlimab in Patients With Advanced Non-small-cell Lung Cancer and/or Malignant Pleural Mesothelioma, Positive for PD-L1 Expression and Germline or Somatic Mutations in the DNA Repair Genes: Rationale and Study Design. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32924477&form=6&db=m Discovery of SK-575 as a Highly Potent and Efficacious Proteolysis-Targeting Chimera Degrader of PARP1 for Treating Cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32939087&form=6&db=m Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32941897&form=6&db=m Application and reflection of genomic scar assays in evaluating the efficacy of platinum salts and PARP inhibitors in cancer therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32942772&form=6&db=m Cytotoxicity and Pro-Apoptotic, Antioxidant and Anti-Inflammatory Activities of Geopropolis Produced by the Stingless Bee Melipona fasciculata Smith. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32951021&form=6&db=m Understanding and addressing barriers to successful adenovirus-based virotherapy for ovarian cancer. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32953627&form=6&db=m Secondary and tertiary ovarian cancer recurrence: what is the best management? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32966758&form=6&db=m PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32977434&form=6&db=m Impact of Polypharmacy for Chronic Ailments in Colon Cancer Patients: A Review Focused on Drug Repurposing. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32983586&form=6&db=m Recent advancements in PARP inhibitors-based targeted cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32988624&form=6&db=m An olaparib window-of-opportunity trial in patients with early-stage endometrial carcinoma: POLEN study. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32997692&form=6&db=m Impact of mutations in homologous recombination repair genes on treatment outcomes for metastatic castration resistant prostate cancer. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33002095&form=6&db=m STAT3 imparts BRCAness by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33002563&form=6&db=m Tankyrase inhibition augments neuronal insulin sensitivity and glucose uptake via AMPK-AS160 mediated pathway. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33005627&form=6&db=m Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) - Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33006584&form=6&db=m PARP inhibition as frontline therapy in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33008098&form=6&db=m Gene Panel Tumor Testing in Ovarian Cancer Patients Significantly Increases the Yield of Clinically Actionable Germline Variants beyond BRCA1/BRCA2. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33012578&form=6&db=m Efficacy of PARP Inhibition in Metastatic Castration-resistant Prostate Cancer is Very Different with Non-BRCA DNA Repair Alterations: Reconstructing Prespecified Endpoints for Cohort B from the Phase 3 PROfound Trial of Olaparib. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33015058&form=6&db=m PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33017467&form=6&db=m The synergistic proapoptotic effect of PARP-1 and HDAC inhibition in cutaneous T-cell lymphoma is mediated via Blimp-1. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33027668&form=6&db=m TGF?R-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33035602&form=6&db=m Lactate dehydrogenase inhibition affects homologous recombination repair independently of cell metabolic asset; implications for anticancer treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33044685&form=6&db=m Poly(ADP-Ribose) Polymerase Inhibitors in Prostate Cancer: Molecular Mechanisms, and Preclinical and Clinical Data. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33045301&form=6&db=m Shrimp shells extracted chitin in silver nanoparticle synthesis: Expanding its prophecy towards anticancer activity in human hepatocellular carcinoma HepG2 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33050515&form=6&db=m PARP1 Deficiency Reduces Tumour Growth by Decreasing E2F1 Hyperactivation: A Novel Mechanism in the Treatment of Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33054085&form=6&db=m ATR addiction in multiple myeloma: synthetic lethal approaches exploiting established therapies. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33055011&form=6&db=m The current landscape of molecular profiling in the treatment of epithelial ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33059228&form=6&db=m The DNA damaging revolution. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33063092&form=6&db=m Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33069804&form=6&db=m Folliculin deficient renal cancer cells exhibit BRCA1 A complex expression impairment and sensitivity to PARP1 inhibitor olaparib. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33071527&form=6&db=m Novel allosteric PARP1 inhibitors for the treatment of BRCA-deficient leukemia. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33073572&form=6&db=m Synthesis and Cytotoxicity Studies of Bioactive Benzofurans from Lavandula agustifolia and Modified Synthesis of Ailanthoidol, Homoegonol, and Egonol. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33079380&form=6&db=m Mitochondria and chronic effects of cancer therapeutics: The clinical implications. diagnostic usage,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33082213&form=6&db=m PARP Inhibitors in Cancer Diagnosis and Therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33091561&form=6&db=m A meta-analysis of reversion mutations in BRCA genes identifies signatures of DNA end-joining repair mechanisms driving therapy resistance. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33093458&form=6&db=m ClC-3/SGK1 regulatory axis enhances the olaparib-induced antitumor effect in human stomach adenocarcinoma. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33094666&form=6&db=m An evaluation of olaparib for the treatment of pancreatic cancer. causal interaction,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33098603&form=6&db=m An assessment of poly (ADP-ribose) polymerase-1 role in normal and cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33101843&form=6&db=m ATM-Dependent Recruitment of BRD7 is required for Transcriptional Repression and DNA Repair at DNA Breaks Flanking Transcriptional Active Regions. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33103613&form=6&db=m Combined treatment with auranofin and trametinib induces synergistic apoptosis in breast cancer cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33108038&form=6&db=m Contributions of PARP-1 rs1136410 C>T polymorphism to the development of cancer. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33109400&form=6&db=m Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33114555&form=6&db=m Olaparib Synergizes the Anticancer Activity of Daunorubicin via Interaction with AKR1C3. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33121449&form=6&db=m Verteporfin inhibits cell proliferation and induces apoptosis in different subtypes of breast cancer cell lines without light activation. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33135237&form=6&db=m Gastrointestinal events with PARP inhibitors in cancer patients: A meta-analysis of phase II/III randomized controlled trials. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33138032&form=6&db=m RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33157194&form=6&db=m A therapeutic update on PARP inhibitors: implications in the treatment of glioma. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33157956&form=6&db=m The efficacy and adverse effects of PARP inhibitor combined with chemotherapy compared with chemotherapy alone in the treatment of cancer patient: A protocol for systematic review. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33159039&form=6&db=m Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33169439&form=6&db=m The p.Ser64Leu and p.Pro104Leu missense variants of PALB2 identified in familial pancreatic cancer patients compromise the DNA damage response. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33171306&form=6&db=m Parthanatos and its associated components: Promising therapeutic targets for cancer. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33179075&form=6&db=m Tanshinone I and simvastatin inhibit melanoma tumour cell growth by regulating poly (ADP ribose) polymerase 1 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33183998&form=6&db=m PARP inhibitors and radiation potentiate liver cell death in vitro. Do hepatocellular carcinomas have an achilles' heel? causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33186520&form=6&db=m Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33187221&form=6&db=m Increased PARP Activity and DNA Damage in NSCLC Patients: The Influence of COPD. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33188153&form=6&db=m Poly(ADP-ribose)polymerase1: A potential molecular marker to identify cancer during colposcopy procedures. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33195396&form=6&db=m Functional Characterization of PALB2 Variants of Uncertain Significance: Toward Cancer Risk and Therapy Response Prediction. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33198203&form=6&db=m BRCA in Gastrointestinal Cancers: Current Treatments and Future Perspectives. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33205017&form=6&db=m Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33205541&form=6&db=m PARP1 and PRC2 double deficiency promotes BRCA-proficient breast cancer growth by modification of the tumor microenvironment. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33211885&form=6&db=m Targeting OGG1 arrests cancer cell proliferation by inducing replication stress. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33214570&form=6&db=m Frequency and prognostic value of mutations associated with the homologous recombination DNA repair pathway in a large pan cancer cohort. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33224881&form=6&db=m Predictive and Prognostic Value of DNA Damage Response Associated Kinases in Solid Tumors. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33231937&form=6&db=m New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33233320&form=6&db=m Therapeutic Potential of PARP Inhibitors in the Treatment of Metastatic Castration-Resistant Prostate Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33236159&form=6&db=m PARP inhibitor resistance and TP53 mutations in patients treated with olaparib for BRCA-mutated cancer: Four case reports. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33254582&form=6&db=m Causing DNA damage and stopping DNA repair - Vitamin D supplementation with Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors may cause selective cell death of cancer cells: A novel therapeutic paradigm utilizing elevated copper levels within the tumour. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33264017&form=6&db=m Discovery of Pamiparib (BGB-290), a Potent and Selective Poly (ADP-ribose) Polymerase (PARP) Inhibitor in Clinical Development. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33268569&form=6&db=m Combinatorial Efficacy of Olaparib with Radiation and ATR Inhibitor Requires PARP1 Protein in Homologous Recombination-Proficient Pancreatic Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33271982&form=6&db=m RB Regulates DNA Double Strand Break Repair Pathway Choice by Mediating CtIP Dependent End Resection. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33273587&form=6&db=m Poly(ADP-ribose) polymerase 1 in genome-wide expression control in Drosophila. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33278683&form=6&db=m Polymer-lipid hybrid nanovesicle-enabled combination of immunogenic chemotherapy and RNAi-mediated PD-L1 knockdown elicits antitumor immunity against melanoma. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33281960&form=6&db=m Identification of an antitumor effect of demethylzeylasteral on human gastric cancer cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33284833&form=6&db=m Association of PARP1-specific polymorphisms and haplotypes with non-small cell lung cancer subtypes. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,1,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33285109&form=6&db=m Differential immunomodulatory effect of PARP inhibition in BRCA1 deficient and competent tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33289285&form=6&db=m Investigating the Mechanistic Inhibitory Discrepancies of Novel Halogen and Alkyl Di-Substituted Oxadiazole-Based Dibenzo-Azepine-Dione Derivatives on Poly (ADP-Ribose) Polymerase-1. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33295810&form=6&db=m The promise and current status of CDK12/13 inhibition for the treatment of cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33297377&form=6&db=m p53 Enhances Artemisia annua L. Polyphenols-Induced Cell Death Through Upregulation of p53-Dependent Targets and Cleavage of PARP1 and Lamin A/C in HCT116 Colorectal Cancer Cells. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33310779&form=6&db=m First-line PARP inhibitors in ovarian cancer: summary of an ESMO Open - Cancer Horizons round-table discussion. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33315519&form=6&db=m PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1). therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33315700&form=6&db=m Current and future landscape of poly (ADP-ribose) polymerase inhibition resistance. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33317392&form=6&db=m PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33318618&form=6&db=m Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33323380&form=6&db=m A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33324554&form=6&db=m New Perspectives for Resistance to PARP Inhibitors in Triple-Negative Breast Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33330019&form=6&db=m MiRNA and LncRNA as Potential Biomarkers in Triple-Negative Breast Cancer: A Review. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33330383&form=6&db=m Nanoparticle Formulations of Poly (ADP-ribose) Polymerase Inhibitors for Cancer Therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33330937&form=6&db=m An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase III? within a flexible DNA repair complex. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33332934&form=6&db=m Enhanced Efficacy of Combined Therapy with Checkpoint Kinase 1 Inhibitor and Rucaparib Via Regulation of Rad-51 Expression in BRCA Wild-Type Epithelial Ovarian Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33333017&form=6&db=m Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33334906&form=6&db=m Attenuation of SRC Kinase Activity Augments PARP Inhibitor-mediated Synthetic Lethality in BRCA2-altered Prostate Tumors. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33341473&form=6&db=m Zebrafish as an in vivo screening tool to establish PARP inhibitor efficacy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33347814&form=6&db=m Myelodysplastic syndrome and acute myeloid leukaemia in patients treated with PARP inhibitors: a safety meta-analysis of randomised controlled trials and a retrospective study of the WHO pharmacovigilance database. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33352723&form=6&db=m PARP Inhibition Increases the Reliance on ATR/CHK1 Checkpoint Signaling Leading to Synthetic Lethality-An Alternative Treatment Strategy for Epithelial Ovarian Cancer Cells Independent from HR Effectiveness. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33352773&form=6&db=m PARP Theranostic Auger Emitters Are Cytotoxic in BRCA Mutant Ovarian Cancer and Viable Tumors from Ovarian Cancer Patients Enable Ex-Vivo Screening of Tumor Response. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33355125&form=6&db=m The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33358233&form=6&db=m Reply to Johann S. de Bono, Maha Hussain, and Jinyu Kang's Letter to the Editor re: Konrad H. Stopsack. Efficacy of PARP Inhibition in Metastatic Castration-resistant Prostate Cancer is Very Different with Non-BRCA DNA Repair Alterations: Reconstructing Prespecified Endpoints for Cohort B from the Phase 3 PROfound Trial of Olaparib. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.09.024. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33358234&form=6&db=m Re: Konrad H. Stopsack. Efficacy of PARP Inhibition in Metastatic Castration-resistant Prostate Cancer is Very Different with Non-BRCA DNA Repair Alterations: Reconstructing Prespecified Endpoints for Cohort B from the Phase 3 PROfound Trial of Olaparib. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.09.024. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33361107&form=6&db=m Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33376347&form=6&db=m Niraparib as Maintenance Therapy in Germline ATM-mutated and Somatic BRCA2-mutated Ovarian Cancer with Brain Metastases: A Case Report and Literature Review. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33376937&form=6&db=m Update on the Role of Poly (ADP-Ribose) Polymerase Inhibitors in the DNA Repair-Deficient Pancreatic Cancers: A Narrative Review. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33382149&form=6&db=m PARP inhibitors in ovarian cancer: An overview of the practice-changing trials. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33391424&form=6&db=m Tephrosin induces apoptosis of human pancreatic cancer cells through the generation of reactive oxygen species. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33392502&form=6&db=m Preclinical and first-in-human-brain-cancer applications of [18F]poly (ADP-ribose) polymerase inhibitor PET/MR. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33408886&form=6&db=m Tryptophanyl-tRNA Synthetase Sensitizes Hormone Receptor-Positive Breast Cancer to Docetaxel-Based Chemotherapy. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33417952&form=6&db=m PARP-1 induces EMT in non-small cell lung carcinoma cells via modulating the transcription factors Smad4, p65 and ZEB1. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33421183&form=6&db=m Haematologic toxicities with PARP inhibitors in cancer patients: an up-to-date meta-analysis of 29 randomized controlled trials. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33422340&form=6&db=m [Recent therapeutic trends in triple-negative metastatic breast cancers: PARP inhibitors, immunotherapies and antibody-drug conjugates]. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33440946&form=6&db=m Integrating PARP inhibitors into the management of breast cancer: where are we? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33441637&form=6&db=m Sustained, local delivery of the PARP inhibitor talazoparib prevents the development of mammary gland hyperplasia in Brca1-deficient mice. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33448186&form=6&db=m Regulation of DNA double-strand break repair pathway choice: a new focus on 53BP1. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33452192&form=6&db=m Randomised phase II trial of olaparib, chemotherapy or olaparib and cediranib in patients with platinum-resistant ovarian cancer (OCTOVA): a study protocol. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33456490&form=6&db=m YQWY Decoction Improves Myocardial Remodeling via Activating the IL-10/Stat3 Signaling Pathway. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33470989&form=6&db=m p66ShcA potentiates the cytotoxic response of triple-negative breast cancers to PARP inhibitors. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33473172&form=6&db=m Targeting autophagy reverses de novo resistance in homologous recombination repair proficient breast cancers to PARP inhibition. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33475295&form=6&db=m PARP Inhibitors in Triple-Negative Breast Cancer Including Those With BRCA Mutations. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33487630&form=6&db=m Alternate therapeutic pathways for PARP inhibitors and potential mechanisms of resistance. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33494937&form=6&db=m Genomic Testing in Patients with Metastatic Castration-resistant Prostate Cancer: A Pragmatic Guide for Clinicians. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33495297&form=6&db=m Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1 immunotherapy in colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33513287&form=6&db=m Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33516088&form=6&db=m Clinical use and mechanisms of resistance for PARP inhibitors in homologous recombination-deficient cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33520115&form=6&db=m Reversing oncogenic transformation with iron chelation. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33524442&form=6&db=m DNA replication stress and emerging prospects for PARG inhibitors in ovarian cancer therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33528729&form=6&db=m PARP1 rs1136410 C/C genotype associated with an increased risk of esophageal cancer in smokers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33529165&form=6&db=m RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33531508&form=6&db=m Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33551306&form=6&db=m Overcoming PARPi resistance: Preclinical and clinical evidence in ovarian cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33554679&form=6&db=m Recent development in the discovery of PARP inhibitors as anticancer agents: a patent update (2016-2020). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33570247&form=6&db=m Efficacy of PARP inhibition combined with EZH2 inhibition depends on BRCA mutation status and microenvironment in breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33572475&form=6&db=m Post-Transcriptional Regulation of PARP7 Protein Stability Is Controlled by Androgen Signaling. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33572586&form=6&db=m The Prognostic Values of PARP-1 Expression in Uveal Melanoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33572647&form=6&db=m PARP1 as a Marker of an Aggressive Clinical Phenotype in Cutaneous Melanoma-A Clinical and an In Vitro Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33576344&form=6&db=m Identification of PARP-1 in cancer stem cells of gastrointestinal cancers: A preliminary study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33578357&form=6&db=m Clinical practice guidelines for BRCA1 and BRCA2 genetic testing. diagnostic usage,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33581682&form=6&db=m Selective modulation by PARP-1 of HIF-1?-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33583364&form=6&db=m Risk of fatigue with PARP inhibitors in cancer patients: a systematic review and meta-analysis of 29 phase II/III randomized controlled trials. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33583720&form=6&db=m Phase 2 Study of Talazoparib in Patients With Homologous Recombination Repair-Deficient Squamous Cell Lung Cancer: Lung-MAP Substudy S1400G. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33589518&form=6&db=m MEK Inhibition Remodels the Immune Landscape of Mutant KRAS Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33589588&form=6&db=m Glycogen synthase kinase 3? inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33589795&form=6&db=m Response prediction biomarkers and drug combinations of PARP inhibitors in prostate cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33594040&form=6&db=m PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33597293&form=6&db=m NAD+ depletion by type I interferon signaling sensitizes pancreatic cancer cells to NAMPT inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33598329&form=6&db=m Current and Future Directions for PARP Inhibition. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33607245&form=6&db=m Can integrative biomarker approaches improve prediction of platinum and PARP inhibitor response in ovarian cancer? causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33610559&form=6&db=m Prevalence of Homologous Recombination Pathway Gene Mutations in Melanoma: Rationale for a New Targeted Therapeutic Approach. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33615184&form=6&db=m PARP Targeted Alpha-Particle Therapy Enhances Response to PD-1 Immune-Checkpoint Blockade in a Syngeneic Mouse Model of Glioblastoma. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33617965&form=6&db=m Estrogen enhances the cytotoxicity of PARP inhibitors on breast cancer cells through stimulating nitric oxide production. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33627408&form=6&db=m Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33627769&form=6&db=m MiRNA-200C expression in Fanconi anemia pathway functionally deficient lung cancers. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33628586&form=6&db=m The cancer-testis gene, MEIOB, sensitizes triple-negative breast cancer to PARP1 inhibitors by inducing homologous recombination deficiency. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33629929&form=6&db=m Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33630577&form=6&db=m Sulfur [18F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33637348&form=6&db=m Utilizing an interim futility analysis of the OVAL study (VB-111-701/GOG 3018) for potential reduction of risk: A phase III, double blind, randomized controlled trial of ofranergene obadenovec (VB-111) and weekly paclitaxel in patients with platinum resistant ovarian cancer. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33637776&form=6&db=m BKM120 sensitizes BRCA-proficient triple negative breast cancer cells to olaparib through regulating FOXM1 and Exo1 expression. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33642013&form=6&db=m Three phytosterols from sweet potato inhibit MCF7-xenograft-tumor growth through modulating gut microbiota homeostasis and SCFAs secretion. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33646064&form=6&db=m Perspectives on PARP inhibitors as pharmacotherapeutic strategies for breast cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33649820&form=6&db=m Inhibitor of apoptosis protein Livin promotes tumor progression and chemoradioresistance in human anaplastic thyroid cancer. diagnostic usage,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33657415&form=6&db=m Avoid the trap: Targeting PARP1 beyond human malignancy. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33660437&form=6&db=m WNT inhibition creates a BRCA-like state in Wnt-addicted cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33660569&form=6&db=m Investigational PARP inhibitors for the treatment of biliary tract cancer: spotlight on preclinical and clinical studies. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33671256&form=6&db=m Identification and Characterization of MortaparibPlus-A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and -Independent Mechanisms. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33684965&form=6&db=m Systematic inhibitor selectivity between PARP1 and PARP2 enzymes: Molecular implications for ovarian cancer personalized therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33691794&form=6&db=m Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33705687&form=6&db=m A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33706586&form=6&db=m PARP1 rs1136410 Val762Ala contributes to an increased risk of overall cancer in the East Asian population: a meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33710464&form=6&db=m Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33724122&form=6&db=m Poly (ADP-ribose) polymerase (PARP) as target for the treatment of epithelial ovarian cancer: what to know. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33734501&form=6&db=m SMURF2-mediated ubiquitin signaling plays an essential role in the regulation of PARP1 PARylating activity, molecular interactions, and functions in mammalian cells. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33737855&form=6&db=m The Synergistic Effect of PARP Inhibitors and Immune Checkpoint Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33738458&form=6&db=m Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33740125&form=6&db=m Efficacy and safety of anti-PD-1-based therapy in combination with PARP inhibitors for patients with advanced solid tumors in a real-world setting. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33740524&form=6&db=m Aqueous extract of Taxus chinensis var. mairei regulates the Hippo-YAP pathway and promotes apoptosis of non-small cell lung cancer via ATF3 in vivo and in vitro. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33740547&form=6&db=m Discovery of novel and potent PARP/PI3K dual inhibitors for the treatment of cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33742140&form=6&db=m Cytoplasmic ADP-ribosylation levels correlate with markers of patient outcome in distinct human cancers. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33742147&form=6&db=m Olaparib increases the therapeutic index of hemithoracic irradiation compared with hemithoracic irradiation alone in a mouse lung cancer model. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33742189&form=6&db=m Resistance to second-generation androgen receptor antagonists in prostate cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33744950&form=6&db=m Shaping the BRCAness mutational landscape by alternative double-strand break repair, replication stress and mitotic aberrancies. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33764593&form=6&db=m Theoretical insights into molecular mechanism and energy criteria of PARP-2 enzyme inhibition by benzimidazole analogues. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33767416&form=6&db=m Identifying patients eligible for PARP inhibitor treatment: from NGS-based tests to 3D functional assays. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33767581&form=6&db=m Preclinical evaluation of radiation therapy of BRCA1-associated mammary tumors using a mouse model. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33777745&form=6&db=m BAP1-Altered Malignant Pleural Mesothelioma: Outcomes With Chemotherapy, Immune Check-Point Inhibitors and Poly(ADP-Ribose) Polymerase Inhibitors. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33784003&form=6&db=m LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination-mediated DNA double strand break repair. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33787008&form=6&db=m Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33788167&form=6&db=m Evaluation of a Low-Toxicity PARP Inhibitor as a Neuroprotective Agent for Parkinson's Disease. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33801950&form=6&db=m Bioinformatic Analysis of the Nicotinamide Binding Site in Poly(ADP-Ribose) Polymerase Family Proteins. diagnostic usage,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33804157&form=6&db=m PARP10 Multi-Site Auto- and Histone MARylation Visualized by Acid-Urea Gel Electrophoresis. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33804647&form=6&db=m Genomic, Transcriptomic, and Functional Alterations in DNA Damage Response Pathways as Putative Biomarkers of Chemotherapy Response in Ovarian Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33804735&form=6&db=m The PARP Way to Epigenetic Changes. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33805293&form=6&db=m The Significance of Targeting Poly (ADP-Ribose) Polymerase-1 in Pancreatic Cancer for Providing a New Therapeutic Paradigm. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33808217&form=6&db=m CRISPR Screens in Synthetic Lethality and Combinatorial Therapies for Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33808562&form=6&db=m Alternative Non-Homologous End-Joining: Error-Prone DNA Repair as Cancer's Achilles' Heel. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33812339&form=6&db=m Treatment landscape of metastatic pancreatic cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33812473&form=6&db=m Breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33818052&form=6&db=m Integrating PARP Inhibitors Into Advanced Prostate Cancer Therapeutics. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33833118&form=6&db=m Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33838082&form=6&db=m Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33853832&form=6&db=m Recruitment of KMT2C/MLL3 to DNA Damage Sites Mediates DNA Damage Responses and Regulates PARP Inhibitor Sensitivity in Cancer. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33859786&form=6&db=m Novel Azaquinolones as PARP1 Inhibitors for Treating Cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33862496&form=6&db=m Poly (ADP-ribose) polymerase inhibitors in solid tumours: Systematic review and meta-analysis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33862558&form=6&db=m PARP inhibitors in head and neck cancer: Molecular mechanisms, preclinical and clinical data. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33863812&form=6&db=m CHK2 Inhibition Provides a Strategy to Suppress Hematologic Toxicity from PARP Inhibitors. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33863820&form=6&db=m Kinetic and static analysis of poly-(adenosine diphosphate-ribose) polymerase-1 (PARP-1) targeted 18F-FluorThanatrace (18F-FTT) PET images of ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33866194&form=6&db=m The spectrum of tumors harboring BAP1 gene alterations. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33868586&form=6&db=m Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33876576&form=6&db=m Human Mass Balance and Metabolite Profiling of [14 C]-Pamiparib, a Poly (ADP-Ribose) Polymerase Inhibitor, in Patients With Advanced Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33882241&form=6&db=m PARP inhibitors and immunotherapy in ovarian and endometrial cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33884961&form=6&db=m In vivo visualization of PARP inhibitor pharmacodynamics. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33886122&form=6&db=m PARP (Poly ADP-Ribose Polymerase) inhibitors for locally advanced or metastatic breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33888155&form=6&db=m Complete pathological response to olaparib and bevacizumab in advanced cervical cancer following chemoradiation in a BRCA1 mutation carrier: a case report. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33888468&form=6&db=m PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33888558&form=6&db=m Interfaces between cellular responses to DNA damage and cancer immunotherapy. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33891252&form=6&db=m PARP inhibitors: shifting the paradigm in the treatment of pancreatic cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33892042&form=6&db=m Poly-l-Lysine inhibits VEGF and c-Myc mediated tumor-angiogenesis and induces apoptosis in 2D and 3D tumor microenvironment of both MDA-MB-231 and B16F10 induced mice model. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33894017&form=6&db=m A Population Pharmacokinetic Meta-Analysis of Veliparib, a PARP Inhibitor, Across Phase 1/2/3 Trials in Cancer Patients. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33910596&form=6&db=m Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33916118&form=6&db=m Targeting Replicative Stress and DNA Repair by Combining PARP and Wee1 Kinase Inhibitors Is Synergistic in Triple Negative Breast Cancers with Cyclin E or BRCA1 Alteration. therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33916521&form=6&db=m Hereditary Prostate Cancer: Genes Related, Target Therapy and Prevention. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33922595&form=6&db=m The PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33922979&form=6&db=m Proteomic Studies on the Management of High-Grade Serous Ovarian Cancer Patients: A Mini-Review. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33923319&form=6&db=m The PARP Enzyme Family and the Hallmarks of Cancer Part 2: Hallmarks Related to Cancer Host Interactions. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33933153&form=6&db=m Functional consequences of a rare missense BARD1 c.403G>A germline mutation identified in a triple-negative breast cancer patient. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33940558&form=6&db=m PARP1: Structural insights and pharmacological targets for inhibition. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33947694&form=6&db=m Detection of Molecular Signatures of Homologous Recombination Deficiency in Bladder Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33948378&form=6&db=m TSL-1502, a glucuronide prodrug of a poly (ADP-ribose) polymerase (PARP) inhibitor, exhibits potent anti-tumor activity in preclinical models. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33950778&form=6&db=m Integrated support vector machine and pharmacophore based virtual screening driven identification of thiophene carboxamide scaffold containing compound as potential PARP1 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33952464&form=6&db=m PARP1 Is Overexpressed in Hematological Malignant Cell Lines: A Framework for Experimental Oncology. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33952676&form=6&db=m A subset of PARP inhibitors induces lethal telomere fusion in ALT-dependent tumor cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33966140&form=6&db=m High BRCA2 Gene Expression is Associated with Aggressive and Highly Proliferative Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33973461&form=6&db=m The new-generation proteasome inhibitor oprozomib increases the sensitivity of cervical cancer cells to cisplatin-induced apoptosis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33981228&form=6&db=m Galangin Inhibits Gastric Cancer Growth Through Enhancing STAT3 Mediated ROS Production. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33981998&form=6&db=m Top1-PARP1 association and beyond: from DNA topology to break repair. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33995588&form=6&db=m Prolonged response to treatment based on cell-free DNA analysis and molecular profiling in three patients with metastatic cancer: a case series. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34012010&form=6&db=m MIF is a 3' flap nuclease that facilitates DNA replication and promotes tumor growth. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34015643&form=6&db=m The role of homologous recombination deficiency testing in ovarian cancer and its clinical implications: do we need it? causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34019811&form=6&db=m Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34023129&form=6&db=m Risk of pneumonitis in cancer patients treated with PARP inhibitors: A meta-analysis of randomized controlled trials and a pharmacovigilance study of the FAERS database. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34025781&form=6&db=m The role of PARP inhibitors in BRCA mutated pancreatic cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34027408&form=6&db=m Targeting IDH1/2 mutant cancers with combinations of ATR and PARP inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34030964&form=6&db=m Studying PAR-Dependent Chromatin Remodeling to Tackle PARPi Resistance. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34037269&form=6&db=m Olaparib Inhibits Tumor Growth of Hepatoblastoma in Patient-Derived Xenograft Models. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34038131&form=6&db=m Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. ongoing research,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34039959&form=6&db=m BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34040699&form=6&db=m Molecular-targeted therapy toward precision medicine for gastrointestinal caner: Current progress and challenges. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34047476&form=6&db=m Identification of biomarkers complementary to homologous recombination deficiency for improving the clinical outcome of ovarian serous cystadenocarcinoma. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34049076&form=6&db=m PARP1-mediated PARylation of TonEBP prevents R-loop-associated DNA damage. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34049655&form=6&db=m PARP inhibitor associated treatment related myeloid neoplasms: What was a "Rare" complication may be less so. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34060485&form=6&db=m Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34065235&form=6&db=m Imprecise Medicine: BRCA2 Variants of Uncertain Significance (VUS), the Challenges and Benefits to Integrate a Functional Assay Workflow with Clinical Decision Rules. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34066020&form=6&db=m The Role of PARP Inhibitors in the Treatment of Prostate Cancer: Recent Advances in Clinical Trials. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34066057&form=6&db=m PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34067105&form=6&db=m Homologous Recombination Repair Deficiency and Implications for Tumor Immunogenicity. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34069967&form=6&db=m Radiosynthesis and Evaluation of Talazoparib and Its Derivatives as PARP-1-Targeting Agents. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34070674&form=6&db=m Breast Cancer Predisposition Genes and Synthetic Lethality. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34070839&form=6&db=m CCNE1 Is a Putative Therapeutic Target for ARID1A-Mutated Ovarian Clear Cell Carcinoma. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34071938&form=6&db=m Clinical Significance of Tumor Infiltrating Lymphocytes in Association with Hormone Receptor Expression Patterns in Epithelial Ovarian Cancer. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34073147&form=6&db=m PARP Inhibitors Talazoparib and Niraparib Sensitize Melanoma Cells to Ionizing Radiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34073600&form=6&db=m Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34079088&form=6&db=m Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34082024&form=6&db=m ATR inhibition amplifies antitumor effects of olaparib in biliary tract cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34085099&form=6&db=m PARP inhibition in UV-associated angiosarcoma preclinical models. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34107345&form=6&db=m PARP inhibitors and newly second primary malignancies in cancer patients: a systematic review and safety meta-analysis of placebo randomized controlled trials. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34107346&form=6&db=m Therapy-related myeloid neoplasms following treatment with PARP inhibitors: new molecular insights. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34107902&form=6&db=m ABBV-176, a PRLR antibody drug conjugate with a potent DNA-damaging PBD cytotoxin and enhanced activity with PARP inhibition. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34108603&form=6&db=m PARP inhibitors promote stromal fibroblast activation by enhancing CCL5 autocrine signaling in ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34111425&form=6&db=m Inhibition of Pim-2 kinase by LT-171-861 promotes DNA damage and exhibits enhanced lethal effects with PARP inhibitor in multiple myeloma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34115723&form=6&db=m Repurposing of Clinically Approved Poly-(Adp-Ribose) Polymerase Inhibitors For The Therapy of Sepsis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34118019&form=6&db=m Fuzuloparib: First Approval. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34118569&form=6&db=m Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity. causal interaction,ongoing research,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34125094&form=6&db=m A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34131002&form=6&db=m Phase 1 Combination Study of the CHK1 Inhibitor Prexasertib and the PARP Inhibitor Olaparib in High-grade Serous Ovarian Cancer and Other Solid Tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34132814&form=6&db=m Association of T2285C polymorphism in PARP1 gene coding region with its expression, activity and NSCLC risk along with prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34133209&form=6&db=m Therapeutic Implications of Germline Testing in Patients With Advanced Cancers. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34139979&form=6&db=m Research progress of PARP inhibitor monotherapy and combination therapy for endometrial cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34140467&form=6&db=m Pol? inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34142045&form=6&db=m ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34145376&form=6&db=m A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34148137&form=6&db=m ATMIN Suppresses Metastasis by Altering the WNT-Signaling Pathway via PARP1 in MSI-High Colorectal Cancer. therapeutic application,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34152463&form=6&db=m [Homologous recombination repair deficiency as a predictive biomarker : Basic mechanisms and detection methods]. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34154315&form=6&db=m [Analysis of PARP inhibitors induced anemia in advanced and relapsed epithelial ovarian cancer]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34158394&form=6&db=m PARP-1 Regulates Estrogen-Dependent Gene Expression in Estrogen Receptor ?-Positive Breast Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34159897&form=6&db=m Exosome component 1 cleaves single-stranded DNA and sensitizes human kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34160752&form=6&db=m Safety, pharmacokinetics, and preliminary efficacy of the PARP inhibitor talazoparib in Japanese patients with advanced solid tumors: phase 1 study. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34163574&form=6&db=m Poly adenosine diphosphate-ribosylation, a promising target for colorectal cancer treatment. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34167572&form=6&db=m PARP inhibitors in gastric cancer: beacon of hope. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34178990&form=6&db=m MCM4 Is a Novel Biomarker Associated With Genomic Instability, BRCAness Phenotype, and Therapeutic Potentials in Soft-Tissue Sarcoma. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34179826&form=6&db=m A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34186467&form=6&db=m Discovery of the PARP (poly ADP-ribose polymerase) inhibitor 2-(1-(4,4-difluorocyclohexyl)piperidin-4-yl)-1H-benzo[d]imidazole-4-carboxamide for the treatment of cancer. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34187942&form=6&db=m Celebrating the 80th anniversary of hormone ablation for prostate cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34194286&form=6&db=m [18F]PARPi Imaging Is Not Affected by HPV Status In Vitro. ongoing research,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34197614&form=6&db=m Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34201616&form=6&db=m The Effects of Chemotherapeutics on the Ovarian Cancer Microenvironment. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34206535&form=6&db=m An Algorithm Combining Patient Performance Status, Second Hit Analysis, PROVEAN and Dann Prediction Tools Could Foretell Sensitization to PARP Inhibitors in Digestive, Skin, Ovarian and Breast Cancers. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34206538&form=6&db=m Prevalence of DNA Repair Gene Mutations in Blood and Tumor Tissue and Impact on Prognosis and Treatment in HNSCC. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34206543&form=6&db=m Nuclear Export Inhibitor KPT-8602 Synergizes with PARP Inhibitors in Escalating Apoptosis in Castration Resistant Cancer Cells. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34207240&form=6&db=m Mutant p53L194F Harboring Luminal-A Breast Cancer Cells Are Refractory to Apoptosis and Cell Cycle Arrest in Response to MortaparibPlus, a Multimodal Small Molecule Inhibitor. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34208195&form=6&db=m Regulation of RAD51 at the Transcriptional and Functional Levels: What Prospects for Cancer Therapy? diagnostic usage,therapeutic application,unassigned 2,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34210965&form=6&db=m Serine-linked PARP1 auto-modification controls PARP inhibitor response. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34224364&form=6&db=m VLX600 Disrupts Homologous Recombination and Synergizes with PARP Inhibitors and Cisplatin by Inhibiting Histone Lysine Demethylases. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34226663&form=6&db=m A transcriptomic model for homologous recombination deficiency in prostate cancer. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34261032&form=6&db=m Repositioning PARP inhibitors in the treatment of thoracic malignancies. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34266953&form=6&db=m Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34280886&form=6&db=m MTA2 sensitizes gastric cancer cells to PARP inhibition by induction of DNA replication stress. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34285417&form=6&db=m Understanding and overcoming resistance to PARP inhibitors in cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34287805&form=6&db=m Pamiparib: First Approval. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34289354&form=6&db=m Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34298999&form=6&db=m Cisplatin Resistance and Redox-Metabolic Vulnerability: A Second Alteration. causal interaction,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34304979&form=6&db=m Computational investigation of FDA approved drugs as selective PARP-1 inhibitors by targeting BRCT domain for cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34305590&form=6&db=m Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34309133&form=6&db=m Rapid Progression of Metastatic Pancreatic Adenocarcinoma During Platinum-Based Therapy in a Patient Harboring a Pathogenic BRCA2 Germline Variant. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34316708&form=6&db=m Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34318678&form=6&db=m PARP-Targeted Auger Therapy in p53 Mutant Colon Cancer Xenograft Mouse Models. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34323956&form=6&db=m Cytoplasmic EBP50 and elevated PARP1 are unfavorable prognostic factors in ovarian clear cell carcinoma. causal interaction,diagnostic usage,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34325086&form=6&db=m Understanding the DNA double-strand break repair and its therapeutic implications. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34329824&form=6&db=m Improved tumor-suppressive effect of OZ-001 combined with cisplatin mediated by mTOR/p70S6K and STAT3 inactivation in A549 human lung cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34342816&form=6&db=m A375 melanoma cells are sensitized to cisplatin-induced toxicity by a synthetic nitro-flavone derivative 2-(4-Nitrophenyl)-4H-chromen-4-one through inhibition of PARP1. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34343132&form=6&db=m Targeting Gi/o protein-coupled receptor signaling blocks HER2-induced breast cancer development and enhances HER2-targeted therapy. ongoing research,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34352995&form=6&db=m Inhibition of WEE1 Potentiates Sensitivity to PARP Inhibitor in Biliary Tract Cancer. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34354944&form=6&db=m Dual Inhibition of PARP and the Intra-S/G2 Cell Cycle Checkpoints Results in Highly Effective Radiosensitization of HPV-Positive HNSCC Cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34356835&form=6&db=m Poly (ADP-Ribose) Polymerase Inhibitor, ABT888, Improved Cisplatin Effect in Human Oral Cell Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34359075&form=6&db=m Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34360649&form=6&db=m Moving beyond PARP Inhibition: Current State and Future Perspectives in Breast Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34363951&form=6&db=m hMOB2 deficiency impairs homologous recombination-mediated DNA repair and sensitises cancer cells to PARP inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34364219&form=6&db=m PARP1 deficiency protects against hyperglycemia-induced neointimal hyperplasia by upregulating TFPI2 activity in diabetic mice. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34364700&form=6&db=m Landmark trials in the medical oncology management of metastatic breast cancer. causal interaction,unassigned 1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34367927&form=6&db=m Mechanisms of acquired resistance of BRCA1/2-driven tumors to platinum compounds and PARP inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34367929&form=6&db=m BRCA mutations and gastrointestinal cancers: When to expect the unexpected? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34370190&form=6&db=m Research progress on the association between environmental pollutants and the resistance mechanism of PARP inhibitors in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34375408&form=6&db=m A potential synthetic lethal strategy with PARP inhibitors: perspective on 'Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP'. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34377227&form=6&db=m Development of PARP inhibitor combinations for castration resistant prostate cancer unselected for homologous recombination repair mutations. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34380074&form=6&db=m Hedgehog/GLI1 Transcriptionally Regulates FANCD2 in Ovarian Tumor Cells: Its Inhibition Induces HR-Deficiency and Synergistic Lethality with PARP Inhibition. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34380641&form=6&db=m Comparative Assessment of Diagnostic Homologous Recombination Deficiency-Associated Mutational Signatures in Ovarian Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34381789&form=6&db=m RECQ1 Promotes Stress Resistance and DNA Replication Progression Through PARP1 Signaling Pathway in Glioblastoma. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34382902&form=6&db=m TRIM44 links the UPS to SQSTM1/p62-dependent aggrephagy and removing misfolded proteins. unassigned - 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34385259&form=6&db=m The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34387603&form=6&db=m Response to olaparib in metastatic lung adenocarcinoma with germline BRCA2 mutation: a case report. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34388386&form=6&db=m Talazoparib monotherapy in metastatic castration-resistant prostate cancer with DNA repair alterations (TALAPRO-1): an open-label, phase 2 trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34389457&form=6&db=m Comparative safety and tolerability of approved PARP inhibitors in cancer: A systematic review and network meta-analysis. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34404206&form=6&db=m Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34407687&form=6&db=m Tumor treating fields combined with a poly (adenosine diphosphate-ribose) polymerase inhibitor during radiotherapy for rapidly progressing IDH-wildtype diffuse astrocytoma: a case report. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34413130&form=6&db=m CX-5461 sensitises DNA damage repair proficient castrate-resistant prostate cancer to PARP inhibition. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34417893&form=6&db=m Activation of proline metabolism maintains ATP levels during cocaine-induced polyADP-ribosylation. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34418731&form=6&db=m Evolutionary dynamics of cancer multidrug resistance in response to olaparib and photodynamic therapy. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34423229&form=6&db=m Utility of Homologous Recombination Deficiency Biomarkers Across Cancer Types. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34425193&form=6&db=m Transferrin-conjugated liposomes loaded with carnosic acid inhibit liver cancer growth by inducing mitochondria-mediated apoptosis. causal interaction,ongoing research,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34432161&form=6&db=m PARP1-modulated chromatin remodeling is a new target for cancer treatment. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34437268&form=6&db=m Sequential Inhibition of PARP and WEE1 Minimizes Toxicity. causal interaction,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34439286&form=6&db=m Recent Advances in Enhancing the Therapeutic Index of PARP Inhibitors in Breast Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34440228&form=6&db=m Therapeutic Potential of PARP Inhibitors in the Treatment of Gastrointestinal Cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34443328&form=6&db=m Unsymmetric Cisplatin-Based Pt(IV) Conjugates Containing a PARP-1 Inhibitor Pharmacophore Tested on Malignant Pleural Mesothelioma Cell Lines. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34450194&form=6&db=m PARPs in lipid metabolism and related diseases. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34450497&form=6&db=m Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34452747&form=6&db=m Germline mutations in Black patients with ovarian, fallopian tube and primary peritoneal carcinomas. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34454564&form=6&db=m Cytotoxic and targeted therapy for BRCA1/2-driven cancers. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34459606&form=6&db=m Copper-Mediated Radiosynthesis of [18F]Rucaparib. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34461785&form=6&db=m Three-component Castagnoli-Cushman reaction with ammonium acetate delivers 2-unsubstituted isoquinol-1-ones as potent inhibitors of poly(ADP-ribose) polymerase (PARP). therapeutic application,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34463214&form=6&db=m Unveiling the mechanistic roles of chlorine substituted phthalazinone-based compounds containing chlorophenyl moiety towards the differential inhibition of poly (ADP-ribose) polymerase-1 in the treatment of lung cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34465787&form=6&db=m Synergistic targeting of BRCA1 mutated breast cancers with PARP and CDK2 inhibition. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34471490&form=6&db=m Revealing biomarkers associated with PARP inhibitors based on genetic interactions in cancer genome. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34475104&form=6&db=m Patients with bi-allelic BRCA1/2 inactivation respond to olaparib treatment across histologic tumor types. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34486071&form=6&db=m Two experts and a newbie: [18F]PARPi vs [18F]FTT vs [18F]FPyPARP-a comparison of PARP imaging agents. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34487986&form=6&db=m Unusual metastasis in BRCA mutated pancreatic cancer while on maintenance Olaparib: Two case reports and review of the literature. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34497808&form=6&db=m PARP1 Inhibitor Combined With Oxaliplatin Efficiently Suppresses Oxaliplatin Resistance in Gastric Cancer-Derived Organoids via Homologous Recombination and the Base Excision Repair Pathway. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34500047&form=6&db=m Analysis of mutation status and homologous recombination deficiency in tumors of patients with germline BRCA1 or BRCA2 mutations and metastatic breast cancer: OlympiAD. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34503215&form=6&db=m Niraparib Suppresses Cholangiocarcinoma Tumor Growth by Inducing Oxidative and Replication Stress. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34503239&form=6&db=m Playing on the Dark Side: SMYD3 Acts as a Cancer Genome Keeper in Gastrointestinal Malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34508175&form=6&db=m A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34513705&form=6&db=m Transferrin-Conjugated Erianin-Loaded Liposomes Suppress the Growth of Liver Cancer by Modulating Oxidative Stress. causal interaction,unassigned 2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34518240&form=6&db=m ATARI trial: ATR inhibitor in combination with olaparib in gynecological cancers with ARID1A loss or no loss (ENGOT/GYN1/NCRI). diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34518297&form=6&db=m Synthetic Lethality in Ovarian Cancer. therapeutic application,unassigned 3,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34519134&form=6&db=m A new underlying mechanism for the neuroprotective effect of bosutinib: Reverting toxicity-induced PARylation in SIN1-mediated neurotoxicity. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34527850&form=6&db=m Ceralasertib-Mediated ATR Inhibition Combined With Olaparib in Advanced Cancers Harboring DNA Damage Response and Repair Alterations (Olaparib Combinations). causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34529761&form=6&db=m Poly (ADP-ribose) polymerase-1 (PARP1) as a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34532366&form=6&db=m Safety profile of poly (ADP-ribose) polymerase (PARP) inhibitors in cancer: a network meta-analysis of randomized controlled trials. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neoplasms, Germ Cell and Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15709096&form=6&db=m Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.4.2.30 Neoplasms, Germ Cell and Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15868402&form=6&db=m Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Neoplasms, Germ Cell and Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20113831&form=6&db=m Analysis of poly(ADP-ribose) polymerase-1 (PARP1) gene alteration in human germ cell tumor cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.4.2.30 Neoplasms, Germ Cell and Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23251575&form=6&db=m Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to Cisplatin and poly (adp-ribose) polymerase inhibition. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms, Germ Cell and Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23486608&form=6&db=m PARP expression in germ cell tumours. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.4.2.30 Neoplasms, Germ Cell and Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23957916&form=6&db=m Parp-1 deficiency in ES cells promotes invasive and metastatic lesions accompanying induction of trophoblast giant cells during tumorigenesis in uterine environment. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Neoplasms, Germ Cell and Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27821802&form=6&db=m Role of DNA repair machinery and p53 in the testicular germ cell cancer: a review. causal interaction,unassigned 4,0 2.4.2.30 Neoplasms, Germ Cell and Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33513287&form=6&db=m Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors. therapeutic application,unassigned 4,0 2.4.2.30 Neoplasms, Germ Cell and Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Neoplastic Cells, Circulating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22307137&form=6&db=m A Phase I Study of Veliparib in Combination with Metronomic Cyclophosphamide in Adults with Refractory Solid Tumors and Lymphomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,3 2.4.2.30 Neoplastic Cells, Circulating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25811344&form=6&db=m Sequences and combinations of multifaceted therapy in advanced prostate cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neoplastic Cells, Circulating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29906251&form=6&db=m Randomized, Double-Blind, Phase II Study of Temozolomide in Combination With Either Veliparib or Placebo in Patients With Relapsed-Sensitive or Refractory Small-Cell Lung Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,4 2.4.2.30 Neoplastic Cells, Circulating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29941481&form=6&db=m The Combination of the PARP Inhibitor Olaparib and the WEE1 Inhibitor AZD1775 as a New Therapeutic Option for Small Cell Lung Cancer. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Neoplastic Cells, Circulating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32571788&form=6&db=m Identification of Somatically Acquired BRCA1/2 Mutations by cfDNA Analysis in Patients with Metastatic Breast Cancer. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Neoplastic Syndromes, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29650809&form=6&db=m [Molecular Targeted Therapies for Hereditary Cancer Syndrome]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16461442&form=6&db=m Poly(ADP-ribose) polymerase (PARP) polymorphisms associated with nephritis and arthritis in systemic lupus erythematosus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19454727&form=6&db=m Poly(ADP-ribose) polymerase-1 regulates the progression of autoimmune nephritis in males by inducing necrotic cell death and modulating inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23928697&form=6&db=m Differential regulation of cell death programs in males and females by Poly (ADP-Ribose) Polymerase-1 and 17? estradiol. ongoing research,unassigned 4,0 2.4.2.30 Nervous System Autoimmune Disease, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30559337&form=6&db=m Interleukin-37 (IL-37) Suppresses Pertussis Toxin-Induced Inflammatory Myopathy in a Rat Model. causal interaction,ongoing research,unassigned 3,3,0 2.4.2.30 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18468963&form=6&db=m Poly ADP-ribose polymerase-1: an international molecule of mystery. therapeutic application,unassigned 2,0 2.4.2.30 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27157545&form=6&db=m PARP inhibition attenuates early brain injury through NF-?B/MMP-9 pathway in a rat model of subarachnoid hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 2.4.2.30 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30680005&form=6&db=m Potential role of poly (ADP-ribose) polymerase in delayed cerebral vasospasm following subarachnoid hemorrhage in rats. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33424554&form=6&db=m Sevoflurane Exposure Induces Neuronal Cell Parthanatos Initiated by DNA Damage in the Developing Brain via an Increase of Intracellular Reactive Oxygen Species. causal interaction,unassigned 3,0 2.4.2.30 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33768369&form=6&db=m PARP overactivation in neurological disorders. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9839818&form=6&db=m Some new insights into the effects of opioids in phasic and tonic nociceptive tests. causal interaction,unassigned 3,0 2.4.2.30 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12573726&form=6&db=m Intrathecal pertussis toxin induces thermal hyperalgesia: involvement of excitatory and inhibitory amino acids. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14768516&form=6&db=m Implications of intrathecal pertussis toxin animal model on the cellular mechanisms of neuropathic pain syndrome. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17976390&form=6&db=m PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18194675&form=6&db=m Poly(ADP-ribose) polymerase inhibition as a novel therapeutic approach against intraepidermal nerve fiber loss and neuropathic pain associated with advanced diabetic neuropathy: a commentary on "PARP Inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy". causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24554509&form=6&db=m Animal models of diabetic neuropathic pain. causal interaction,unassigned 4,0 2.4.2.30 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27904474&form=6&db=m Poly(ADP-ribose) polymerase inhibition reveals a potential mechanism to promote neuroprotection and treat neuropathic pain. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32283287&form=6&db=m PARP-1-regulated TNF-? expression in the dorsal root ganglia and spinal dorsal horn contributes to the pathogenesis of neuropathic pain in rats. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Neuritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10808045&form=6&db=m Experimental allergic neuritis in the SJL/J mouse: induction of severe and reproducible disease with bovine peripheral nerve myelin and pertussis toxin with or without interleukin-12. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neuritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11104510&form=6&db=m P0 protein peptide 180-199 together with pertussis toxin induces experimental autoimmune neuritis in resistant C57BL/6 mice. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Neuritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30006715&form=6&db=m Myelin Protein Zero180-199 Peptide Induced Experimental Autoimmune Neuritis in C57BL/6 Mice. ongoing research,unassigned 1,0 2.4.2.30 Neuritis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10808045&form=6&db=m Experimental allergic neuritis in the SJL/J mouse: induction of severe and reproducible disease with bovine peripheral nerve myelin and pertussis toxin with or without interleukin-12. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Neuritis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11104510&form=6&db=m P0 protein peptide 180-199 together with pertussis toxin induces experimental autoimmune neuritis in resistant C57BL/6 mice. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Neuritis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30006715&form=6&db=m Myelin Protein Zero180-199 Peptide Induced Experimental Autoimmune Neuritis in C57BL/6 Mice. ongoing research,unassigned 1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1348983&form=6&db=m Synergism in cytosolic Ca2+ mobilization between bradykinin and agonists for pertussis toxin-sensitive G-protein-coupled receptors in NG 108-15 cells. unassigned - 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1847209&form=6&db=m Effect of chronic D-Ala,2 D-Leu5-enkephalin or pertussis toxin treatment on the high-affinity state of delta opioid receptor in neuroblastoma x glioma NG108-15 hybrid cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,1,1 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2173926&form=6&db=m Pertussis toxin inhibits alpha 2-adrenoceptor-mediated inhibition of adenylate cyclase without affecting muscarinic regulation of [Ca2+]i or inositol phosphate generation in SH-SY5Y human neuroblastoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2426098&form=6&db=m Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2454296&form=6&db=m Chronic exposure to pertussis toxin alters muscarinic receptor-mediated regulation of cyclic AMP metabolism in neuroblastoma x glioma NG108-15 hybrid cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2568113&form=6&db=m Neurotensin, bradykinin and somatostatin inhibit cAMP production in neuroblastoma N1E115 cells via both pertussis toxin sensitive and insensitive mechanisms. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2849940&form=6&db=m Bradykinin-induced generation of inositol 1,4,5-trisphosphate in fibroblasts and neuroblastoma cells: effect of pertussis toxin, extracellular calcium, and down-regulation of protein kinase C. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2869405&form=6&db=m Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2886351&form=6&db=m Role of a protein regulating guanine nucleotide binding in phosphoinositide breakdown and calcium mobilization by bradykinin in neuroblastoma X glioma hybrid NG108-15 cells: effects of pertussis toxin and cholera toxin on receptor-mediated signal transduction. ongoing research,unassigned 3,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2981400&form=6&db=m Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2991740&form=6&db=m Effects of pertussis toxin on cAMP and cGMP responses to carbamylcholine in N1E-115 neuroblastoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2997225&form=6&db=m Effect of pertussis toxin treatment on the down-regulation of opiate receptors in neuroblastoma X glioma NG108-15 hybrid cells. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3010077&form=6&db=m Neurotensin-mediated inhibition of cyclic AMP formation in neuroblastoma N1E115 cells: involvement of the inhibitory GTP-binding component of adenylate cyclase. causal interaction,unassigned 1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3025278&form=6&db=m Muscarinic cholinergic receptor-induced enhancement of PGE1-stimulated cAMP accumulation in neuroblastoma X glioma cells: prevention by pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3080332&form=6&db=m The GTP-binding regulatory proteins of neuroblastoma x glioma, NG108-15, and glioma, C6, cells. Immunochemical evidence of a pertussis toxin substrate that is neither Ni nor No. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3129188&form=6&db=m Identification of a guanine nucleotide-binding protein G(o) in human neuroblastoma. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3133329&form=6&db=m Differential radiosensitization by the poly(ADP-ribose) transferase inhibitor 3-aminobenzamide in human tumor cells of varying radiosensitivity. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3137927&form=6&db=m Opioid peptides promote cholera-toxin-catalysed ADP-ribosylation of the inhibitory guanine-nucleotide-binding protein (Gi) in membranes of neuroblastoma x glioma hybrid cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3390705&form=6&db=m Muscarinic receptor-mediated hydrolysis of phosphatidylinositols in human neuroblastoma (SH-SY5Y) cells is sensitive to pertussis toxin. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6300102&form=6&db=m Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6319865&form=6&db=m Pertussis toxin decreases opiate receptor binding and adenylate inhibition in a neuroblastoma x glioma hybrid cell line. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7652193&form=6&db=m Identification and characterization of functional angiotensin II receptors in human neuroblastoma cells. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7782330&form=6&db=m Coupling of human D-1 dopamine receptors to different guanine nucleotide binding proteins. Evidence that D-1 dopamine receptors can couple to both Gs and G(o). therapeutic application,unassigned 3,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7830057&form=6&db=m Coupling of the human Y2 receptor for neuropeptide Y and peptide YY to guanine nucleotide inhibitory proteins in permeabilized SMS-KAN cells. therapeutic application,unassigned 1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7902295&form=6&db=m Inversion of Ca2+ current modulation during recovery of neuroblastoma cells from pertussis toxin pretreatment. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7968671&form=6&db=m Morphological effects, rate of incorporation, and the enzymatic action of botulinum ADP-ribosyltransferase, known as C3 exoenzyme, on human neuroblastoma GOTO cells. ongoing research,unassigned 4,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8642645&form=6&db=m Temporal changes in chromatin, intracellular calcium, and poly(ADP-ribose) polymerase during Sindbis virus-induced apoptosis of neuroblastoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9041562&form=6&db=m Possible involvement of ADP-ribosylation of particular enzymes in cell death induced by nitric oxide-donors in human neuroblastoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9453543&form=6&db=m Peroxynitrite and hydrogen peroxide induced cell death in the NSC34 neuroblastoma x spinal cord cell line: role of poly (ADP-ribose) polymerase. ongoing research,unassigned 3,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9855633&form=6&db=m Protective effects of the antiparkinsonian drugs talipexole and pramipexole against 1-methyl-4-phenylpyridinium-induced apoptotic death in human neuroblastoma SH-SY5Y cells. unassigned - 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10762713&form=6&db=m Poly (ADP-ribose) polymerase induction is an early signal of apoptosis in human neuroblastoma. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10847582&form=6&db=m Functional trans-inactivation of insulin receptor kinase by growth-inhibitory angiotensin II AT2 receptor. unassigned - 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11461973&form=6&db=m Apoptotic signaling in dopamine-induced cell death: the role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11853409&form=6&db=m Rapid activation of poly(ADP-ribose) polymerase contributes to Sindbis virus and staurosporine-induced apoptotic cell death. causal interaction,ongoing research,unassigned 2,4,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12399599&form=6&db=m Characterization of a neutralizing monoclonal antibody against botulinum ADP-ribosyltransferase, C3 exoenzyme. ongoing research,unassigned 3,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15547726&form=6&db=m Synergistic induction of apoptosis in neuroblastoma cells using a combination of cytostatic drugs with interferon-gamma and TRAIL. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17283398&form=6&db=m Neural differentiation of human neuroblastoma GOTO cells via a Rho-Rho kinase-phosphorylation signal transduction and continuous observation of a single GOTO cell during differentiation. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17975142&form=6&db=m Expression of Prenylated Rab Acceptor 1 Domain Family, Member 2 (PRAF2) in Neuroblastoma: Correlation with Clinical Features, Cellular Localization, and Cerulenin-Mediated Apoptosis Regulation. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18059134&form=6&db=m Inhibition of gamma ray-induced apoptosis by stimulatory heterotrimeric GTP binding protein involves Bcl-xL down-regulation in SH-SY5Y human neuroblastoma cells. ongoing research,unassigned 4,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18246814&form=6&db=m [Inhibition of tissue factor by siRNA enhances doxorubicin-induced apoptosis in human neuroblastoma] unassigned - 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18481334&form=6&db=m Cytoprotective effects of phenolic acids on methylglyoxal-induced apoptosis in Neuro-2A cells. unassigned - 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19174487&form=6&db=m Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19770030&form=6&db=m Chrysanthemum morifolium Ramat (CM) extract protects human neuroblastoma SH-SY5Y cells against MPP(+)-induced cytotoxicity. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20459571&form=6&db=m High level of apoptosis and low AKT activation in mass screening as opposed to standard neuroblastoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21215776&form=6&db=m Low levels of selenium compounds are selectively toxic for a human neuron cell line through ROS/RNS increase and apoptotic process activation. therapeutic application,unassigned 1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21365766&form=6&db=m Biological Effects of MC2050, a Quinazoline-Based PARP-1 Inhibitor, in Human Neuroblastoma and EBV-Positive Burkitt's Lymphoma Cells. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21441600&form=6&db=m Poly(ADP-ribose) polymerase-1 is a nuclear epigenetic regulator of mitochondrial DNA repair and transcription. therapeutic application,unassigned 1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21859926&form=6&db=m Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22210004&form=6&db=m Characterization of Chikungunya virus infection in human neuroblastoma SH-SY5Y cells: role of apoptosis in neuronal cell death. ongoing research,unassigned 2,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22245810&form=6&db=m Generation of reactive oxygen species mediates butein-induced apoptosis in neuroblastoma cells. causal interaction,unassigned 1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23074024&form=6&db=m Suppressive effect of PARP-1 inhibitor on JC virus replication in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23097134&form=6&db=m Sodium valproate potentiates staurosporine-induced apoptosis in neuroblastoma cells via Akt/survivin independently of HDAC inhibition. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23482742&form=6&db=m Poly (ADP-Ribose) Polymerase Inhibitor MK-4827 together with Radiation as a Novel Therapy for Metastatic Neuroblastoma. therapeutic application,unassigned 4,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24070777&form=6&db=m The toxicity of nitrofuran compounds on melanoma and neuroblastoma cells is enhanced by Olaparib and ameliorated by melanin pigment. therapeutic application,unassigned 2,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24086258&form=6&db=m PARP-1 Modulates Amyloid Beta Peptide-Induced Neuronal Damage. ongoing research,unassigned 2,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25563294&form=6&db=m Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25736927&form=6&db=m Oncolytic adenovirus-mediated short hairpin RNA targeting MYCN gene induces apoptosis by upregulating RKIP in neuroblastoma. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25936609&form=6&db=m The novel anti-neuroblastoma agent PF403, inhibits proliferation and invasion in vitro and in brain xenografts. ongoing research,unassigned 1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26505995&form=6&db=m Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27197168&form=6&db=m mda-7/IL-24 Induces Cell Death in Neuroblastoma through a Novel Mechanism Involving AIF and ATM. therapeutic application,unassigned 2,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27515310&form=6&db=m An evaluation in vitro of PARP-1 inhibitors, rucaparib and olaparib, as radiosensitisers for the treatment of neuroblastoma. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27567859&form=6&db=m The Polyphenol Oleuropein Aglycone Modulates the PARP1-SIRT1 Interplay: An In Vitro and In Vivo Study. therapeutic application,unassigned 1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28394338&form=6&db=m PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28830922&form=6&db=m Deletion of 11q in neuroblastomas drives sensitivity to PARP inhibition. therapeutic application,unassigned 2,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29059438&form=6&db=m Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29238067&form=6&db=m Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation. unassigned - 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29452418&form=6&db=m PHF20 collaborates with PARP1 to promote stemness and aggressiveness of neuroblastoma cells through activation of SOX2 and OCT4. therapeutic application,unassigned 1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30034627&form=6&db=m CRISPR/Cas9 nickase mediated targeting of urokinase receptor gene inhibits neuroblastoma cell proliferation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31072830&form=6&db=m Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical Models. causal interaction,diagnostic usage,unassigned 4,2,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31413734&form=6&db=m PARP1 gene polymorphisms and neuroblastoma susceptibility in Chinese children. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31676730&form=6&db=m PARP-1-targeted Auger emitters display high-LET cytotoxic properties in vitro but show limited therapeutic utility in solid tumor models of human neuroblastoma. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32061800&form=6&db=m Cr(VI) induces ROS-mediated mitochondrial-dependent apoptosis in neuronal cells via the activation of Akt/ERK/AMPK signaling pathway. ongoing research,unassigned 3,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32103589&form=6&db=m Association of PARP1 polymorphisms with response to chemotherapy in patients with high-risk neuroblastoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32354033&form=6&db=m ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,4 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32577161&form=6&db=m MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33615184&form=6&db=m PARP Targeted Alpha-Particle Therapy Enhances Response to PD-1 Immune-Checkpoint Blockade in a Syngeneic Mouse Model of Glioblastoma. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34451847&form=6&db=m Pyrido[2',1':2,3]imidazo[4,5-c]isoquinolin-5-amines as Potential Cytotoxic Agents against Human Neuroblastoma. therapeutic application,unassigned 3,0 2.4.2.30 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34508175&form=6&db=m A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10407112&form=6&db=m Poly(ADP-ribose) polymerase is found in both the nucleus and cytoplasm of human CNS neurons. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11501263&form=6&db=m [Neuronal death: potential role of the nuclear enzyme, poly (ADP-ribose) polymerase] causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11846617&form=6&db=m Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors. causal interaction,unassigned 3,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12628304&form=6&db=m Development of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12675907&form=6&db=m Poly(ADP-ribose) polymerase-1 activity promotes NF-kappaB-driven transcription and microglial activation: implication for neurodegenerative disorders. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14670625&form=6&db=m The PARP inhibitor benzamide protects against kainate and NMDA but not AMPA lesioning of the mouse striatum in vivo. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14985416&form=6&db=m Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-[3-[4-(4-chlorophenyl)-1-piperazinyl] propyl]-4(3H)-quinazolinone (FR255595), in an in vitro model of cell death and in mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075382&form=6&db=m A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15113847&form=6&db=m A new poly(ADP-ribose) polymerase inhibitor, FR261529 [2-(4-chlorophenyl)-5-quinoxalinecarboxamide], ameliorates methamphetamine-induced dopaminergic neurotoxicity in mice. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15257133&form=6&db=m The expression of PARP, NF-kappa B and parvalbumin is increased in Parkinson disease. causal interaction,unassigned 3,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15561303&form=6&db=m Poly(ADP-ribose) polymerases: homology, structural domains and functions. Novel therapeutical applications. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16357945&form=6&db=m Development of a miniaturized assay for the high-throughput screening program for poly(ADP-ribose) polymerase-1. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17347665&form=6&db=m Poly(ADP-ribose) polymerase-1 protects neurons against apoptosis induced by oxidative stress. causal interaction,unassigned 4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17430191&form=6&db=m Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18417297&form=6&db=m Poly(ADP-ribose) signal in seizures-induced neuron death. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19526300&form=6&db=m Protection Against Chronic Hypoperfusion-Induced Retinal Neurodegeneration by PARP Inhibition via Activation of PI-3-kinase Akt Pathway and Suppression of JNK and p38 MAP Kinases. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22476980&form=6&db=m Natural Inhibitors of Poly(ADP-ribose) Polymerase-1. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23921685&form=6&db=m Post-transcriptional regulation by poly(ADP-ribosyl)ation of the RNA-binding proteins. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24420784&form=6&db=m Ceramide in the Molecular Mechanisms of Neuronal Cell Death. The Role of Sphingosine-1-Phosphate. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25881554&form=6&db=m PARP-1 involvement in neurodegeneration: A focus on Alzheimer's and Parkinson's diseases. ongoing research,unassigned 2,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25999161&form=6&db=m Identification and mechanism of action analysis of the new PARP-1 inhibitor 2?-hydroxygenkwanol A. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26091340&form=6&db=m The Promise of Proteomics for the Study of ADP-Ribosylation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27624574&form=6&db=m PARP10 deficiency manifests by severe developmental delay and DNA repair defect. causal interaction,unassigned 4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28130107&form=6&db=m Extracellular poly(ADP-ribose) is a neurotrophic signal that upregulates glial cell line-derived neurotrophic factor (GDNF) levels in vitro and in vivo. causal interaction,unassigned 3,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28302009&form=6&db=m Expression and Single Nucleotide Polymorphism of Poly (ADPRibose) Polymerase-1 in Gastrointestinal Tumours: Clinical Involvement. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28600955&form=6&db=m PARP activity and inhibition in fetal and adult oligodendrocyte precursor cells: Effect on cell survival and differentiation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28674991&form=6&db=m Cell Death Mechanisms of Neurodegeneration. causal interaction,unassigned 1,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29128369&form=6&db=m Inhibition of poly(ADP-ribose) polymerase-1 alters expression of mitochondria-related genes in PC12 cells: relevance to mitochondrial homeostasis in neurodegenerative disorders. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29327278&form=6&db=m Nicotinamide Inhibits Ethanol-Induced Caspase-3 and PARP-1 Over-activation and Subsequent Neurodegeneration in the Developing Mouse Cerebellum. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29383691&form=6&db=m Early Treatment with Poly(ADP-Ribose) Polymerase-1 Inhibitor (JPI-289) Reduces Infarct Volume and Improves Long-Term Behavior in an Animal Model of Ischemic Stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30390553&form=6&db=m Synthesis and evaluation of an AZD2461 [18F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant. ongoing research,unassigned 1,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30414941&form=6&db=m Poly(ADP-ribosylated) proteins in ?-amyloid peptide-stimulated microglial cells. therapeutic application,unassigned 4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31034795&form=6&db=m New insights of poly(ADP-ribosylation) in neurodegenerative diseases: A focus on protein phase separation and pathologic aggregation. causal interaction,unassigned 4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31102582&form=6&db=m PARPs and PAR as novel pharmacological targets for the treatment of stress granule-associated disorders. causal interaction,unassigned 1,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31182245&form=6&db=m Poly(ADP-Ribosylation) in Age-Related Neurological Disease. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31451894&form=6&db=m Drug repurposing studies of PARP inhibitors as a new therapy for inherited retinal degeneration. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31754701&form=6&db=m Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31877876&form=6&db=m Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32066462&form=6&db=m mTOR may interact with PARP-1 to regulate visible light-induced parthanatos in photoreceptors. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32621411&form=6&db=m [Poly adenosine diphosphate-ribosylation and neurodegenerative diseases]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32903806&form=6&db=m Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer's Disease. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32987654&form=6&db=m Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA. therapeutic application,unassigned 4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33387580&form=6&db=m Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33460497&form=6&db=m The role of PARP1 in neurodegenerative diseases and aging. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33631119&form=6&db=m PARP-DNA trapping ability of PARP inhibitors jeopardizes astrocyte viability: Implications for CNS disease therapeutics. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34082062&form=6&db=m PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34198048&form=6&db=m The impact of the phytotherapeutic agent quercetin on expression of genes and activity of signaling pathways. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34391789&form=6&db=m PARkinson's: From cellular mechanisms to potential therapeutics. causal interaction,unassigned 3,0 2.4.2.30 Neuroectodermal Tumors, Primitive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15328205&form=6&db=m Antiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors. causal interaction,unassigned 1,0 2.4.2.30 Neuroendocrine Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24243533&form=6&db=m Novel insights into the neuroendocrine control of inflammation: the role of GR and PARP1. causal interaction,unassigned 3,0 2.4.2.30 Neuroendocrine Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29872498&form=6&db=m Potentiation of 177Lu-octreotate peptide receptor radionuclide therapy of human neuroendocrine tumor cells by PARP inhibitor. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Neuroendocrine Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34329582&form=6&db=m The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Neurofibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26650448&form=6&db=m Poly (ADP) ribose polymerase inhibition: A potential treatment of malignant peripheral nerve sheath tumor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.4.2.30 Neurofibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31848295&form=6&db=m Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas. causal interaction,unassigned 2,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11694334&form=6&db=m Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911339&form=6&db=m Clinical perspectives of PARP inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19409222&form=6&db=m Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats and prevents glutamate transporter downregulation by suppressing the p38 mitogen-activated protein kinase signaling pathway. ongoing research,unassigned 2,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19684606&form=6&db=m Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE. unassigned - 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22078487&form=6&db=m Targeting poly(ADP-ribose) polymerase-1 as a promising approach for immunomodulation in multiple sclerosis? causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23607899&form=6&db=m Poly(ADP-ribose) polymerase 2 contributes to neuroinflammation and neurological dysfunction in mouse experimental autoimmune encephalomyelitis. therapeutic application,unassigned 2,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24151909&form=6&db=m Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in A?(1-42)-induced rat model of Alzheimer's disease. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25863272&form=6&db=m Poly (ADP-ribose) polymerase-1 inhibitor, 3-aminobenzamide pretreatment ameliorates lipopolysaccharide-induced neurobehavioral and neurochemical anomalies in mice. therapeutic application,unassigned 4,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26522738&form=6&db=m Edaravone abrogates LPS-induced behavioral anomalies, neuroinflammation and PARP-1. therapeutic application,unassigned 1,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26921631&form=6&db=m PARP inhibition attenuates neuroinflammation and oxidative stress in chronic constriction injury induced peripheral neuropathy. causal interaction,unassigned 4,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27084773&form=6&db=m Morin Mitigates Chronic Constriction Injury (CCI)-Induced Peripheral Neuropathy by Inhibiting Oxidative Stress Induced PARP Over-Activation and Neuroinflammation. causal interaction,unassigned 4,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27712995&form=6&db=m Combination strategy of PARP inhibitor with antioxidant prevent bioenergetic deficits and inflammatory changes in CCI-induced neuropathy. causal interaction,unassigned 3,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29052145&form=6&db=m Cell Death Pathways: a Novel Therapeutic Approach for Neuroscientists. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29128369&form=6&db=m Inhibition of poly(ADP-ribose) polymerase-1 alters expression of mitochondria-related genes in PC12 cells: relevance to mitochondrial homeostasis in neurodegenerative disorders. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29383691&form=6&db=m Early Treatment with Poly(ADP-Ribose) Polymerase-1 Inhibitor (JPI-289) Reduces Infarct Volume and Improves Long-Term Behavior in an Animal Model of Ischemic Stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29779175&form=6&db=m Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3? Signaling in LPS-Treated Adult Mice. causal interaction,diagnostic usage,unassigned 1,1,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30390553&form=6&db=m Synthesis and evaluation of an AZD2461 [18F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant. ongoing research,unassigned 1,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31251945&form=6&db=m PARP inhibition in vivo blocks alcohol-induced brain neurodegeneration and neuroinflammatory cytosolic phospholipase A2 elevations. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31454809&form=6&db=m Neuroinflammation and B-Cell Phenotypes in Cervical and Lumbosacral Regions of the Spinal Cord in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin. unassigned - 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32327659&form=6&db=m Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration. causal interaction,unassigned 2,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32903806&form=6&db=m Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer's Disease. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33460497&form=6&db=m The role of PARP1 in neurodegenerative diseases and aging. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34025565&form=6&db=m Targeting Parthanatos in Ischemic Stroke. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34115723&form=6&db=m Repurposing of Clinically Approved Poly-(Adp-Ribose) Polymerase Inhibitors For The Therapy of Sepsis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Neuroma, Acoustic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20150366&form=6&db=m DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. unassigned - 2.4.2.30 Neutropenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19604089&form=6&db=m Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Neutropenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29075104&form=6&db=m Risk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: a meta-analysis of randomized controlled trials. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Neutropenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33254040&form=6&db=m Efficacy and safety of PARP inhibitors in the treatment of advanced ovarian cancer: An updated systematic review and meta-analysis of randomized controlled trials. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Neutropenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33421183&form=6&db=m Haematologic toxicities with PARP inhibitors in cancer patients: an up-to-date meta-analysis of 29 randomized controlled trials. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Newcastle Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28988534&form=6&db=m Biochemical Variations in Cytolytic Activity of Ortho- and Paramyxoviruses in Human Lung Tumor Cell Culture. unassigned - 2.4.2.30 Nijmegen Breakage Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15204703&form=6&db=m Identification of proteins in the hamster DNA end-binding complex. diagnostic usage,unassigned 1,0 2.4.2.30 Nijmegen Breakage Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22396666&form=6&db=m DNA Damage in Nijmegen Breakage Syndrome Cells Leads to PARP Hyperactivation and Increased Oxidative Stress. causal interaction,ongoing research,unassigned 3,1,0 2.4.2.30 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27663419&form=6&db=m Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27979751&form=6&db=m PARP1-mediated PPAR? poly(ADP-ribosyl)ation suppresses fatty acid oxidation in non-alcoholic fatty liver disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 2.4.2.30 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28013023&form=6&db=m Metabolic roles of poly(ADP-ribose) polymerases. diagnostic usage,unassigned 3,0 2.4.2.30 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30861601&form=6&db=m Mitigative effects of the bioactive flavonol fisetin on high-fat/high-sucrose induced nonalcoholic fatty liver disease in rats. ongoing research,unassigned 3,0 2.4.2.30 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30907226&form=6&db=m Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity. unassigned - 2.4.2.30 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31913745&form=6&db=m SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. ongoing research,unassigned 2,0 2.4.2.30 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34450194&form=6&db=m PARPs in lipid metabolism and related diseases. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 non-specific serine/threonine protein kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21506732&form=6&db=m p53 Inhibits Adeno-Associated Viral Vector Integration. causal interaction,unassigned 3,0 2.4.2.30 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20338998&form=6&db=m PARP-1 DEFICIENCY EXACERBATES DIET-INDUCED OBESITY IN MICE. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20421936&form=6&db=m Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23800102&form=6&db=m The beneficial role of vitamin D in obesity: possible genetic and cell signaling mechanisms. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.2.30 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25448685&form=6&db=m Enhanced susceptibility of ovaries from obese mice to 7,12-dimethylbenz[a]anthracene-induced DNA damage. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28203708&form=6&db=m Obesity alters phosphoramide mustard-induced ovarian DNA repair in mice. causal interaction,unassigned 3,0 2.4.2.30 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28664098&form=6&db=m Antagonistic crosstalk between SIRT1, PARP-1, and -2 in the regulation of chronic inflammation associated with aging and metabolic diseases. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32822587&form=6&db=m Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis. unassigned - 2.4.2.30 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32946760&form=6&db=m PARP-1 Flips the Epigenetic Switch on Obesity. unassigned - 2.4.2.30 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34450194&form=6&db=m PARPs in lipid metabolism and related diseases. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Oligospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25106941&form=6&db=m Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Optic Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11526433&form=6&db=m Increased expression and activation of poly(ADP-ribose) polymerase (PARP) contribute to retinal ganglion cell death following rat optic nerve transection. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15743888&form=6&db=m Involvement of poly(ADP-ribose) polymerase 1 in ERBB2 expression in rheumatoid synovial cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.4.2.30 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34254815&form=6&db=m PARP-1 inhibition attenuates the inflammatory response in the cartilage of a rat model of osteoarthritis. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 2.4.2.30 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25917236&form=6&db=m Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing. ongoing research,unassigned 3,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2429669&form=6&db=m Effects of phorbol esters and pertussis toxin on agonist-stimulated cyclic AMP production in rat osteosarcoma cells. ongoing research,unassigned 3,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7821713&form=6&db=m Evidence against roles for pertussis toxin sensitive G proteins or diacylglycerol generation in insulin-like growth factor-1 stimulated DNA synthesis in MG-63 osteosarcoma cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9593711&form=6&db=m Transient poly(ADP-ribosyl)ation of nuclear proteins and role of poly(ADP-ribose) polymerase in the early stages of apoptosis. ongoing research,unassigned 1,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10331650&form=6&db=m Involvement of PARP and poly(ADP-ribosyl)ation in the early stages of apoptosis and DNA replication. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10438458&form=6&db=m Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11494111&form=6&db=m Poly(ADP-ribosyl)ation of p53 in vitro and in vivo modulates binding to its DNA consensus sequence. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11694507&form=6&db=m Regulation of DNAS1L3 endonuclease activity by poly(ADP-ribosyl)ation during etoposide-induced apoptosis. Role of poly(ADP-ribose) polymerase-1 cleavage in endonuclease activation. unassigned - 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12140175&form=6&db=m Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14612922&form=6&db=m The effect of 3-aminobenzamide, inhibitor of poly(ADP-ribose) polymerase, on human osteosarcoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15670817&form=6&db=m Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18977144&form=6&db=m Poly(ADP-ribose) polymerase-1 activity facilitates the dissociation of nuclear proteins from platinum-modified DNA. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19638450&form=6&db=m Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20459702&form=6&db=m Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21246613&form=6&db=m Inhibition of mTOR signaling by oleanolic acid contributes to its anti-tumor activity in osteosarcoma cells. causal interaction,unassigned 1,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21399492&form=6&db=m Inhibition of polo-like kinase 1 leads to the suppression of osteosarcoma cell growth in vitro and in vivo. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21399878&form=6&db=m The poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide suppresses cell growth and migration, enhancing suppressive effects of cisplatin in osteosarcoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22927942&form=6&db=m Fluoroquinolone-mediated inhibition of cell growth, s-g(2)/m cell cycle arrest, and apoptosis in canine osteosarcoma cell lines. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22940495&form=6&db=m Hydrogen peroxide-induced poly(ADP-ribosyl)ation regulates osteogenic differentiation-associated cell death. ongoing research,unassigned 1,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24840134&form=6&db=m Targeted inhibition of mTORC2 prevents osteosarcoma cell migration and promotes apoptosis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25109871&form=6&db=m Isoalantolactone inhibits constitutive NF-?B activation and induces reactive oxygen species-mediated apoptosis in osteosarcoma U2OS cells through mitochondrial dysfunction. causal interaction,unassigned 4,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26712686&form=6&db=m Blocking HSP90 Addiction Inhibits Tumor Cell Proliferation, Metastasis Development, and Synergistically Acts with Zoledronic Acid to Delay Osteosarcoma Progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27447864&form=6&db=m Osteosarcoma cells with genetic signatures of BRCAness are susceptible to the PARP inhibitor talazoparib alone or in combination with chemotherapeutics. therapeutic application,unassigned 2,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27651058&form=6&db=m [The clonal evolution of osteosarcomas]. therapeutic application,unassigned 1,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27656839&form=6&db=m Knockdown of PARP-1 Inhibits Proliferation and ERK Signals, Increasing Drug Sensitivity in Osteosarcoma U2OS Cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29313488&form=6&db=m Replication Study: Systematic identification of genomic markers of drug sensitivity in cancer cells. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29323455&form=6&db=m Selenocysteine inhibits human osteosarcoma cells growth through triggering mitochondrial dysfunction and ROS-mediated p53 phosphorylation. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29784019&form=6&db=m The PARP inhibitor olaparib potentiates the effect of the DNA damaging agent doxorubicin in osteosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30395907&form=6&db=m Combinatorial screening using orthotopic patient derived xenograft-expanded early phase cultures of osteosarcoma identify novel therapeutic drug combinations. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30926223&form=6&db=m Tankyrase1 antisense oligodeoxynucleotides suppress the proliferation, migration and invasion through Hippo/YAP pathway in human osteosarcoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31394674&form=6&db=m Interferon-? Sensitises Human Osteosarcoma Cells to Trail-mediated Apoptosis. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32190974&form=6&db=m Betulin inhibits mTOR and induces autophagy to promote apoptosis in human osteosarcoma cell lines. therapeutic application,unassigned 3,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32721630&form=6&db=m CCT128930 induces G1-phase arrest and apoptosis and synergistically enhances the anticancer efficiency of VS5584 in human osteosarcoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33614474&form=6&db=m ClC-5 Downregulation Induces Osteosarcoma Cell Apoptosis by Promoting Bax and tBid Complex Formation. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33945829&form=6&db=m PARP1 modulates telomere sister chromatid exchange and telomere length homeostasis by regulating telomere localization of SLX4 in U2OS cells. ongoing research,unassigned 4,0 2.4.2.30 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34003554&form=6&db=m Maclurin exerts anti-cancer effects in human osteosarcoma cells via prooxidative activity and modulations of PARP, p38, and ERK signaling. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24922076&form=6&db=m Augmentation of NAD(+) by NQO1 attenuates cisplatin-mediated hearing impairment. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26341473&form=6&db=m Dunnione ameliorates cisplatin ototoxicity through modulation of NAD(+) metabolism. causal interaction,unassigned 1,0 2.4.2.30 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31021006&form=6&db=m Baicalin attenuates gentamicin-induced cochlear hair cell ototoxicity. unassigned - 2.4.2.30 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31551715&form=6&db=m Poly (ADP-Ribose) Polymerase-1 (PARP1) Deficiency and Pharmacological Inhibition by Pirenzepine Protects From Cisplatin-Induced Ototoxicity Without Affecting Antitumor Efficacy. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12085231&form=6&db=m Induction of apoptosis by the new anticancer drug XK469 in human ovarian cancer cell lines. ongoing research,unassigned 2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15041999&form=6&db=m Evidence for tight coupling of Gi protein-mediated lysophosphatidic acid receptor to stimulated cytokine production in ovarian cancer cell. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15843893&form=6&db=m Structure-based design of an agonistic peptide targeting Fas. ongoing research,unassigned 2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16044162&form=6&db=m Lysophosphatidic acid and endothelin-induced proliferation of ovarian cancer cell lines is mitigated by neutralization of granulin-epithelin precursor (GEP), a prosurvival factor for ovarian cancer. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16209885&form=6&db=m A small molecule compound inhibits AKT pathway in ovarian cancer cell lines. therapeutic application,unassigned 1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17620430&form=6&db=m ZD4054, a specific antagonist of the endothelin A receptor, inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18837894&form=6&db=m The potential of PARP inhibitors in genetic breast and ovarian cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18842335&form=6&db=m Antiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent heat shock protein 90 inhibitors in human cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20017885&form=6&db=m PARP inhibitors and the treatment of breast cancer: beyond BRCA1/2? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20027033&form=6&db=m High poly(adenosine diphosphate-ribose) polymerase expression and poor survival in advanced-stage serous ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20124459&form=6&db=m ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20130818&form=6&db=m Targeted therapy in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20164690&form=6&db=m Poly(ADP-ribose) polymerase inhibitors in triple-negative breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20187322&form=6&db=m Inhibition of poly(ADP)-ribose polymerase as a therapeutic strategy for breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20298590&form=6&db=m Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20371688&form=6&db=m Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20406170&form=6&db=m Inducing Synthetic Lethality using PARP Inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20485165&form=6&db=m PARP inhibition: targeting the Achilles' heel of DNA repair to treat germline and sporadic ovarian cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20606085&form=6&db=m Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20609468&form=6&db=m Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20643861&form=6&db=m A review of PARP inhibitors: from bench to bedside. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20645701&form=6&db=m Poly(ADP-ribosyl)ation polymerases: mechanism and new target of anticancer therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20656109&form=6&db=m PARP inhibition in BRCA-mutated breast and ovarian cancers. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20700108&form=6&db=m Making the best of PARP inhibitors in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20852632&form=6&db=m A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. unassigned - 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20973257&form=6&db=m Moving toward personalized medicine: treatment-focused genetic testing of women newly diagnosed with ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21187397&form=6&db=m Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21371001&form=6&db=m Identification of BRCA1-deficient ovarian cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21445297&form=6&db=m Enhancing chemotherapy response with bmi-1 silencing in ovarian cancer. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21504625&form=6&db=m Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21521830&form=6&db=m Recent progress in the diagnosis and treatment of ovarian cancer. causal interaction,diagnostic usage,unassigned 3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21537476&form=6&db=m Targeted therapies in epithelial ovarian cancer: Molecular mechanisms of action. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21570976&form=6&db=m The BRCA1 ubiquitin ligase and homologous recombination repair. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21613406&form=6&db=m Poly(ADP-Ribose) Polymerase Inhibition Synergizes with 5-Fluorodeoxyuridine but not 5-Fluorouracil in Ovarian Cancer Cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21721203&form=6&db=m [PARP inhibitors: new therapeutic agents in breast and ovarian cancer]. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21757288&form=6&db=m Magnolol down-regulates HER2 gene expression, leading to inhibition of HER2-mediated metastatic potential in ovarian cancer cells. therapeutic application,unassigned 2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21819606&form=6&db=m Drug therapy for hereditary cancers. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21913063&form=6&db=m PARP inhibitors in BRCA gene-mutated ovarian cancer and beyond. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21922196&form=6&db=m Genomic instability in breast and ovarian cancers: translation into clinical predictive biomarkers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22110186&form=6&db=m Synthetic oleanane triterpenoid, CDDO-Me, induces apoptosis in ovarian cancer cells by inhibiting prosurvival AKT/NF-?B/mTOR signaling. unassigned - 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22137482&form=6&db=m Targeting genetic and epigenetic alterations in the treatment of serous ovarian cancer. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22180407&form=6&db=m Update on PARP1 inhibitors in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22203755&form=6&db=m Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22203759&form=6&db=m Comparing poly (ADP-ribose) polymerase inhibitors with standard chemotherapy in BRCA-mutated, recurrent ovarian cancer: lessons learned from a negative trial. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22401667&form=6&db=m Advances in using PARP inhibitors to treat cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22489346&form=6&db=m The maze of PARP inhibitors in ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22591423&form=6&db=m The Role of PARP Inhibitors in the Treatment of Ovarian Carcinomas. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22706117&form=6&db=m [PARP inhibitors--theoretical basis and clinical application]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22788971&form=6&db=m Olaparib , PARP1 inhibitor in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22801507&form=6&db=m HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22833573&form=6&db=m Identification of DNA Repair Pathways that Affect the Survival of Ovarian Cancer Cells Treated with a PARP Inhibitor in a Novel Drug Combination. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22926640&form=6&db=m Clinical trials and future potential of targeted therapy for ovarian cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22983827&form=6&db=m Association between polymorphisms of XRCC1 and ADPRT genes and ovarian cancer survival with platinum-based chemotherapy in Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22987487&form=6&db=m HER2 Overexpression Renders Human Breast Cancers Sensitive to PARP Inhibition Independently of Any Defect in Homologous Recombination DNA Repair. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23307860&form=6&db=m New strategies in the treatment of ovarian cancer: current clinical perspectives and future potential. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23370117&form=6&db=m Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23396107&form=6&db=m Inhibition of Poly(ADP-Ribose) Polymerase Enhances Radiochemosensitivity in Cancers Proficient in DNA Double-Strand Break Repair. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23415752&form=6&db=m BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23442605&form=6&db=m Promoter hypomethylation, especially around the E26 transformation-specific motif, and increased expression of poly (ADP-ribose) polymerase 1 in BRCA-mutated serous ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23474708&form=6&db=m Inhibition of Hec1 expression enhances the sensitivity of human ovarian cancer cells to paclitaxel. causal interaction,diagnostic usage,unassigned 3,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23548269&form=6&db=m ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23619942&form=6&db=m Olaparib: a promising PARP inhibitor in ovarian cancer therapy. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23640560&form=6&db=m Effects of poly (ADP-ribosyl) polymerase (PARP) inhibitor on cisplatin resistance & proliferation of the ovarian cancer C13* cells. ongoing research,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23666017&form=6&db=m Cost-effectiveness of BRCA1 and BRCA2 mutation testing to target PARP inhibitor use in platinum-sensitive recurrent ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23729402&form=6&db=m Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib for the treatment of sporadic human ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23739867&form=6&db=m Expression profiles of vault components MVP, TEP1 and vPARP and their correlation to other multidrug resistance proteins in ovarian cancer. causal interaction,diagnostic usage,unassigned 4,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23762410&form=6&db=m An antimitotic and antivascular agent BPR0L075 overcomes multidrug resistance and induces mitotic catastrophe in paclitaxel-resistant ovarian cancer cells. therapeutic application,unassigned 1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23847380&form=6&db=m Olaparib shows promise in multiple tumor types. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23922302&form=6&db=m Efficacy of Chemotherapy in BRCA1/2 Mutation Carrier Ovarian Cancer in the Setting of PARP Inhibitor Resistance: A Multi-Institutional Study. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24033642&form=6&db=m Involvement of homologous recombination in the synergism between cisplatin and poly(ADP-ribose) polymerase inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24043945&form=6&db=m Emerging treatment options for recurrent ovarian cancer: the potential role of olaparib. unassigned - 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24097829&form=6&db=m Inhibition of proliferation and invasiveness of ovarian cancer C13* cells by a poly(ADP-ribose) polymerase inhibitor and the role of nuclear factor-?B. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24129347&form=6&db=m Appraising iniparib, the PARP inhibitor that never was--what must we learn? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24131965&form=6&db=m BRCA1- and BRCA2-related mutations: therapeutic implications in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24168967&form=6&db=m miR-9 regulation of BRCA1 and ovarian cancer sensitivity to cisplatin and PARP inhibition. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24265409&form=6&db=m New developments in the treatment of ovarian cancer--future perspectives. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24413181&form=6&db=m Triapine Disrupts CtIP-Mediated Homologous Recombination Repair and Sensitizes Ovarian Cancer Cells to PARP and Topoisomerase Inhibitors. therapeutic application,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24448423&form=6&db=m Poly (ADP-ribose) polymerase 1 transcriptional regulation: a novel crosstalk between histone modification H3K9ac and ETS1 motif hypomethylation in BRCA1-mutated ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24451760&form=6&db=m Biologicals in the Upfront Treatment of Ovarian Cancer: Focus on Bevacizumab and Poly (ADP-Ribose) Polymerase Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24554720&form=6&db=m Ovarian Cancer-associated Mutations Disable Catalytic Activity of CDK12, a Kinase That Promotes Homologous Recombination Repair and Resistance to Cisplatin and Poly(ADP-ribose) Polymerase Inhibitors. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24555961&form=6&db=m Hereditary ovarian carcinomas: clinico-biological features and treatment. causal interaction,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24579064&form=6&db=m BRCA 1/2-Mutation Related and Sporadic Breast and Ovarian Cancers: More Alike than Different. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24607283&form=6&db=m PARP inhibitors in ovarian cancer: Current status and future promise. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24616882&form=6&db=m Beyond Breast and Ovarian Cancers: PARP Inhibitors for BRCA Mutation-Associated and BRCA-Like Solid Tumors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24654681&form=6&db=m Novel therapies, including enzastaurin, in the treatment of ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24727989&form=6&db=m Successes and limitations of targeted cancer therapy in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24778008&form=6&db=m Advanced epithelial ovarian cancer: from standard chemotherapy to promising molecular pathway targets--where are we now? causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24841718&form=6&db=m Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24844596&form=6&db=m An ex vivo assay of XRT-induced Rad51 foci formation predicts response to PARP-inhibition in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24857070&form=6&db=m Molecular profiling and commercial predication assays in ovarian cancer: still not ready for prime time? causal interaction,unassigned 1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24882434&form=6&db=m Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial. diagnostic usage,therapeutic application,unassigned 1,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24895135&form=6&db=m Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression. therapeutic application,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24984781&form=6&db=m PARP inhibition and synthetic lethality in ovarian cancer. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25025963&form=6&db=m Phase I study of olaparib in combination with liposomal doxorubicin in patients with advanced solid tumours. therapeutic application,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25093514&form=6&db=m Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25232497&form=6&db=m Monepantel induces autophagy in human ovarian cancer cells through disruption of the mTOR/p70S6K signalling pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25292178&form=6&db=m Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25301481&form=6&db=m Bacillus intermedius ribonuclease (BINASE) induces apoptosis in human ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25320365&form=6&db=m New strategies in ovarian cancer: translating the molecular complexity of ovarian cancer into treatment advances. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25366685&form=6&db=m Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25437005&form=6&db=m A genomic instability score in discriminating nonequivalent outcomes of BRCA1/2 mutations and in predicting outcomes of ovarian cancer treated with platinum-based chemotherapy. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25481790&form=6&db=m PARP inhibitors in BRCA mutation-associated ovarian cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25481791&form=6&db=m Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer: a randomised phase 2 trial. causal interaction,diagnostic usage,unassigned 3,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25490527&form=6&db=m It is not all about BRCA: Cullin-Ring ubiquitin Ligases in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25499884&form=6&db=m Carboplatin and taxol resistance develops more rapidly in functional BRCA1 compared to dysfunctional BRCA1 ovarian cancer cells. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25509983&form=6&db=m Anticancer activity of pristimerin in ovarian carcinoma cells is mediated through the inhibition of prosurvival Akt/NF-?B/mTOR signaling. unassigned - 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25554012&form=6&db=m PARP inhibition in ovarian cancer: state of the science. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25589624&form=6&db=m Randomized Trial of Oral Cyclophosphamide and Veliparib in High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers, or BRCA-Mutant Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25606064&form=6&db=m PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25616855&form=6&db=m Olaparib approved for advanced ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25663310&form=6&db=m Autophagy and protein kinase RNA-like endoplasmic reticulum kinase (PERK)/eukaryotic initiation factor 2 alpha kinase (eIF2?) pathway protect ovarian cancer cells from metformin-induced apoptosis. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25708226&form=6&db=m PARP inhibitors: A new era of targeted therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25725131&form=6&db=m Two decades beyond BRCA1/2: Homologous recombination, hereditary cancer risk and a target for ovarian cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25757679&form=6&db=m Olaparib: an oral PARP-1 and PARP-2 inhibitor with promising activity in ovarian cancer. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25764827&form=6&db=m [On the prospects of using the DNA repair inhibitors in radiotherapy of tumors]. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25799992&form=6&db=m REV7 counteracts DNA double-strand break resection and affects PARP inhibition. causal interaction,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25865228&form=6&db=m Autoimmune response to PARP and BRCA1/BRCA2 in cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25868852&form=6&db=m Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25883215&form=6&db=m Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25962155&form=6&db=m Conventional chemotherapy and oncogenic pathway targeting in ovarian carcinosarcoma using a patient-derived tumorgraft. causal interaction,diagnostic usage,unassigned 4,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25991068&form=6&db=m Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25995442&form=6&db=m Augmentation of response to chemotherapy by microRNA-506 through regulation of RAD51 in serous ovarian cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,3 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26047697&form=6&db=m The PARP1 inhibitor BMN 673 exhibits immunoregulatory effects in a Brca1(-/-) murine model of ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26051946&form=6&db=m Safety evaluation of olaparib for treating ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26097394&form=6&db=m PARP inhibitors and more. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26097871&form=6&db=m Drug conjugation to hyaluronan widens therapeutic indications for ovarian cancer. therapeutic application,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26097887&form=6&db=m A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26124328&form=6&db=m Co-treatment with BEZ235 Enhances Sensitivity of BRCA1-negative Breast Cancer Cells to Olaparib. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26124641&form=6&db=m Combination of erlotinib and a PARP inhibitor inhibits growth of A2780 tumor xenografts due to increased autophagy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26138335&form=6&db=m CTLA-4 Blockade Synergizes Therapeutically with PARP Inhibition in BRCA1-Deficient Ovarian Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26169965&form=6&db=m Development of Olaparib for BRCA-Deficient Recurrent Epithelial Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26198537&form=6&db=m Development of a multiparameter flow cytometric assay as a potential biomarker for homologous recombination deficiency in women with high-grade serous ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26212149&form=6&db=m Poly(ADP-ribose) polymerase inhibitor therapeutic effect: are we just scratching the surface? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26281686&form=6&db=m [Cancer therapy by PARP inhibitors]. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26303225&form=6&db=m PARP inhibitor maintenance therapy for patients with platinum-sensitive recurrent ovarian cancer: a cost-effectiveness analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26309417&form=6&db=m Olaparib in the management of ovarian cancer. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26344206&form=6&db=m Targeting Human Poly(ADP-Ribose) Polymerase-1 with Natural Medicines and Its Potential Applications in Ovarian Cancer Therapeutics. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26354718&form=6&db=m Chemotherapy reduces PARP1 in cancers of the ovary: implications for future clinical trials involving PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26384693&form=6&db=m [From poly(ADP-ribose) discovery to PARP inhibitors in cancer therapy]. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26402249&form=6&db=m Pancreatic cancer: BRCA mutation and personalized treatment. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26424664&form=6&db=m Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26485111&form=6&db=m Advances in PARP inhibitors for the treatment of breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26504023&form=6&db=m Antitumor Activity of 3-Indolylmethanamines 31B and PS121912. unassigned - 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26518896&form=6&db=m PARP inhibition: A promising therapeutic target in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26520390&form=6&db=m Editorial. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26577420&form=6&db=m Expression of potential biomarkers associated with homologous recombination repair in patients with ovarian or triple-negative breast cancer. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26669449&form=6&db=m PARP inhibitors in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26669450&form=6&db=m PARP inhibitors in ovarian cancer: Clinical evidence for informed treatment decisions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26669451&form=6&db=m UK BRCA mutation testing in patients with ovarian cancer. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26669452&form=6&db=m The development of PARP inhibitors in ovarian cancer: from bench to bedside. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26691937&form=6&db=m [Recommended Extension of Indication Criteria for Genetic Testing of BRCA1 and BRCA2 Mutations in Hereditary Breast and Ovarian Cancer Syndrome]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26694829&form=6&db=m Leveraging DNA repair deficiency in gynecologic oncology. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26723501&form=6&db=m Efficacy and safety of olaparib monotherapy in germline BRCA1/2 mutation carriers with advanced ovarian cancer and three or more lines of prior therapy. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26753012&form=6&db=m Clinical features and outcomes of germline mutation BRCA1-linked versus sporadic ovarian cancer patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26774475&form=6&db=m Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26779812&form=6&db=m Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26800494&form=6&db=m Genetic and epigenetic heterogeneity of epithelial ovarian cancer and the clinical implications for molecular targeted therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26807493&form=6&db=m Veliparib for the treatment of ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26899229&form=6&db=m Cediranib, a pan-VEGFR inhibitor, and olaparib, a PARP inhibitor, in combination therapy for high grade serous ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26909613&form=6&db=m Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26927065&form=6&db=m Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26931795&form=6&db=m New Targeted Agents in Gynecologic Cancers: Synthetic Lethality, Homologous Recombination Deficiency, and PARP Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26937492&form=6&db=m Olaparib for the treatment of ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26942837&form=6&db=m Targeted agents and combinations in ovarian cancer: where are we now? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26959114&form=6&db=m Reciprocal positive selection for weakness - preventing olaparib resistance by inhibiting BRCA2. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26961146&form=6&db=m Olaparib monotherapy in patients with advanced relapsed ovarian cancer and a germline BRCA1/2 mutation: a multi-study analysis of response rates and safety. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26961668&form=6&db=m Recent Patents for Homologous Recombination Deficiency Assays Among Women with Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26967466&form=6&db=m Olaparib for the treatment of epithelial ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26984416&form=6&db=m What Is the Place of PARP Inhibitors in Ovarian Cancer Treatment? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27016230&form=6&db=m Copy number deletion of RAD50 as predictive marker of BRCAness and PARP inhibitor response in BRCA wild type ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27022037&form=6&db=m Clinical Application of Poly(ADP-Ribose) Polymerase Inhibitors in High-Grade Serous Ovarian Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27036617&form=6&db=m An HTS-compatible HTRF assay measuring the glycohydrolase activity of human PARG. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27037296&form=6&db=m BRCA somatic mutations and epigenetic BRCA modifications in serous ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27051448&form=6&db=m Effect of Amino Acids on the Generation of Ginsenoside Rg3 Epimers by Heat Processing and the Anticancer Activities of Epimers in A2780 Human Ovarian Cancer Cells. unassigned - 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27065456&form=6&db=m Homologous recombination deficiency and ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27087632&form=6&db=m Evaluation of rucaparib and companion diagnostics in the PARP inhibitor landscape for recurrent ovarian cancer therapy. diagnostic usage,therapeutic application,unassigned 1,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27141062&form=6&db=m Progress in the treatment of ovarian cancer-lessons from homologous recombination deficiency-the first 10 years. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27141070&form=6&db=m PARP inhibitors in ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27169997&form=6&db=m Molecular Pathways: Targeting DNA Repair Pathway Defects Enriched in Metastasis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27186080&form=6&db=m Profile of olaparib in the treatment of advanced ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27197267&form=6&db=m The BRCA1-?11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27225819&form=6&db=m BRCA1-2 diagnostic workflow from next-generation sequencing technologies to variant identification and final report. therapeutic application,unassigned 1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27231574&form=6&db=m New treatment option for ovarian cancer: PARP inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27249731&form=6&db=m Gynecologic Cancers: Emerging Novel Strategies for Targeting DNA Repair Deficiency. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27282964&form=6&db=m Preclinical evaluation of olaparib and metformin combination in BRCA1 wildtype ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27306290&form=6&db=m Inhibitory PARP w terapii raka jajnika. therapeutic application,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27345073&form=6&db=m The integration of BRCA testing into oncology clinics. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27385701&form=6&db=m Olaparib for the treatment of BRCA-mutated advanced ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27415012&form=6&db=m ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27415751&form=6&db=m Anticancer potential of diarylidenyl piperidone derivatives, HO-4200 and H-4318, in cisplatin resistant primary ovarian cancer. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27416328&form=6&db=m An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27426307&form=6&db=m Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27444036&form=6&db=m Panobinostat sensitizes cyclin E high, homologous recombination-proficient ovarian cancer to olaparib. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27455135&form=6&db=m DNA damage response as a therapeutic target in gynecological cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27487106&form=6&db=m The status of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors in ovarian cancer, part 1: olaparib. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27498558&form=6&db=m Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27533253&form=6&db=m Simultaneous detection of BRCA mutations and large genomic rearrangements in germline DNA and FFPE tumor samples. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27596623&form=6&db=m Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27613518&form=6&db=m 53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27614696&form=6&db=m In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27617661&form=6&db=m Overall survival in patients with platinum-sensitive recurrent serous ovarian cancer receiving olaparib maintenance monotherapy: an updated analysis from a randomised, placebo-controlled, double-blind, phase 2 trial. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27634150&form=6&db=m Update on Poly-ADP-ribose polymerase inhibition for ovarian cancer treatment. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27642590&form=6&db=m Predictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized Medicine. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27668317&form=6&db=m Effects of PARP-1 inhibitor and ERK inhibitor on epithelial mesenchymal transitions of the ovarian cancer SKOV3 cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27673289&form=6&db=m The status of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors in ovarian cancer, part 2: extending the scope beyond olaparib and BRCA1/2 mutations. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27678458&form=6&db=m Biomarkers of Response and Resistance to DNA Repair Targeted Therapies. therapeutic application,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27702817&form=6&db=m Ovarian Cancers Harbor Defects in Nonhomologous End Joining Resulting in Resistance to Rucaparib. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27716873&form=6&db=m The current status of PARP inhibitors in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27736844&form=6&db=m PARP inhibitors for BRCA1/2-mutated and sporadic ovarian cancer: current practice and future directions. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27739325&form=6&db=m A randomized Phase II study of veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in BRCA1/2 metastatic breast cancer: design and rationale. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27745744&form=6&db=m Effect of Itraconazole and Rifampin on the Pharmacokinetics of Olaparib in Patients With Advanced Solid Tumors: Results of Two Phase I Open-label Studies. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27810860&form=6&db=m Niraparib Slows Ovarian Cancer Progression. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27824811&form=6&db=m Quality of life during olaparib maintenance therapy in platinum-sensitive relapsed serous ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27869447&form=6&db=m [Testing of mutations in BRCA1 and BRCA2 genes in tumor tissues - possibilities and limitations]. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27884198&form=6&db=m Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27907908&form=6&db=m Prevalence and clinical significance of BRCA1/2 germline and somatic mutations in Taiwanese patients with ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27917619&form=6&db=m Practical guidance on the use of olaparib capsules as maintenance therapy for women with BRCA mutations and platinum-sensitive recurrent ovarian cancer. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27924011&form=6&db=m Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction. ongoing research,unassigned 1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27940438&form=6&db=m Genomic LOH May Predict Rucaparib Response in Ovarian Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27958297&form=6&db=m Delivering widespread BRCA testing and PARP inhibition to patients with ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27959768&form=6&db=m PARP Inhibitors in Ovarian Cancer Treatment. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27978798&form=6&db=m Combination Platinum-based and DNA Damage Response-targeting Cancer Therapy: Evolution and Future Directions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27993965&form=6&db=m Targeting the ATR/CHK1 axis with PARP inhibition results in tumor regression in BRCA mutant ovarian cancer models. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27995810&form=6&db=m A comprehensive look of poly(ADP-ribose) polymerase inhibition strategies and future directions for cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28003236&form=6&db=m Targeting DNA Repair in Cancer: Beyond PARP Inhibitors. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28033382&form=6&db=m Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28057616&form=6&db=m Rucaparib Approved for Ovarian Cancer. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28073364&form=6&db=m Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28087320&form=6&db=m Poly(ADP-ribose) polymerase activity and inhibition in cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28101214&form=6&db=m PARP-1 may be involved in angiogenesis in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28118040&form=6&db=m PARP-1 Expression Quantified by [ ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28212573&form=6&db=m Dynamic variations in epithelial-to-mesenchymal transition (EMT), ATM, and SLFN11 govern response to PARP inhibitors and cisplatin in small cell lung cancer. therapeutic application,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28234008&form=6&db=m (+)-Strebloside-Induced Cytotoxicity in Ovarian Cancer Cells Is Mediated through Cardiac Glycoside Signaling Networks. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28258387&form=6&db=m [BRCA diagnostics of ovarian cancer : Molecular tumor testing since the introduction of PARP inhibitor therapy]. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28281524&form=6&db=m MiR-216b increases cisplatin sensitivity in ovarian cancer cells by targeting PARP1. diagnostic usage,unassigned 1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28299955&form=6&db=m Niraparib for the treatment of ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,1 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28325851&form=6&db=m New quantitative mass spectrometry approaches reveal different ADP-ribosylation phases dependent on the levels of oxidative stress. therapeutic application,unassigned 1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28350129&form=6&db=m Apoptosis is augmented in high-grade serous ovarian cancer by the combined inhibition of Bcl-2/Bcl-xL and PARP. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28380314&form=6&db=m Understanding Exceptional Responses to Poly (ADP-ribose) Polymerase Inhibition in Sporadic Ovarian Cancer. causal interaction,unassigned 2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28414200&form=6&db=m Combining 53BP1 with BRCA1 as a biomarker to predict the sensitivity of poly(ADP-ribose) polymerase (PARP) inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28425306&form=6&db=m Therapeutic targeting and patient selection for cancers with homologous recombination defects. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28432813&form=6&db=m Targeting on poly(ADP-ribose) polymerase activity with DNA-damaging hybrid lactam-steroid alkylators in wild-type and BRCA1-mutated ovarian cancer cells. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454085&form=6&db=m Baseline clinical predictors of antitumor response to the PARP inhibitor olaparib in germline BRCA1/2 mutated patients with advanced ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454214&form=6&db=m Genome-wide analysis of gynecologic cancer: The Cancer Genome Atlas in ovarian and endometrial cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28471247&form=6&db=m The safety of antiangiogenic agents and PARP inhibitors in platinum-sensitive recurrent ovarian cancer. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28486465&form=6&db=m FDA approves PARP inhibitor for ovarian cancer. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28491146&form=6&db=m PARP inhibitors in ovarian cancer: evidence, experience and clinical potential. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28497333&form=6&db=m Next-Generation Sequencing-based genomic profiling of brain metastases of primary ovarian cancer identifies high number of BRCA-mutations. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28505221&form=6&db=m Combining PI3K and PARP inhibitors for breast and ovarian cancer treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28508305&form=6&db=m Recent advances in targeting DNA repair pathways for the treatment of ovarian cancer and their clinical relevance. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28546758&form=6&db=m Distinct implications of different BRCA mutations: efficacy of cytotoxic chemotherapy, PARP inhibition and clinical outcome in ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28569838&form=6&db=m USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response. ongoing research,unassigned 1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28583748&form=6&db=m Development of PARP inhibitors in gynecological malignancies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28598107&form=6&db=m [The Antitumor Effects of Fisetin on Ovarian Cancer in vitro and in vivo.] causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28601509&form=6&db=m Olaparib hydroxamic acid derivatives as dual PARP and HDAC inhibitors for cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28643177&form=6&db=m Targeting DNA repair and replication stress in the treatment of ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28650468&form=6&db=m MKP-1 suppresses PARP-1 degradation to mediate cisplatin resistance. causal interaction,unassigned 1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28692638&form=6&db=m The First Nationwide Multicenter Prevalence Study of Germline BRCA1 and BRCA2 Mutations in Chinese Ovarian Cancer Patients. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28692916&form=6&db=m Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28695500&form=6&db=m Quantification of PARP Activity in Human Tissues: Ex Vivo Assays in Blood Cells and Immunohistochemistry in Human Biopsies. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28747513&form=6&db=m Repression of BET activity sensitizes homologous recombination-proficient cancers to PARP inhibition. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28754483&form=6&db=m Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28754563&form=6&db=m Changes in gene expression variability reveal a stable synthetic lethal interaction network in BRCA2- ovarian cancers. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28756516&form=6&db=m Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28765325&form=6&db=m Diverse BRCA1 and BRCA2 Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28770827&form=6&db=m Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy. causal interaction,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28780754&form=6&db=m FDA Approval of PARP Inhibitors and the Impact on Genetic Counseling and Genetic Testing Practices. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28790837&form=6&db=m Rucaparib: the past, present, and future of a newly approved PARP inhibitor for ovarian cancer. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28800469&form=6&db=m Immunotherapy in ovarian, endometrial and cervical cancer: State of the art and future perspectives. therapeutic application,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28881380&form=6&db=m Missed therapeutic and prevention opportunities in women with BRCA-mutated epithelial ovarian cancer and their families due to low referral rates for genetic counseling and BRCA testing: A review of the literature. therapeutic application,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28916367&form=6&db=m Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28916370&form=6&db=m PARP inhibitors for targeted treatment in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28916446&form=6&db=m Cancer-derived exosomes as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting. unassigned - 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28925391&form=6&db=m EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28933580&form=6&db=m The Role of Cediranib in Ovarian Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28981112&form=6&db=m Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28984489&form=6&db=m Directing the use of DDR kinase inhibitors in cancer treatment. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28994419&form=6&db=m Targeted therapy: ARIEL3 - broad benefit of PARP inhibitors in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28994564&form=6&db=m Targeted therapy for ovarian cancer: the rapidly evolving landscape of PARP inhibitor use. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29021870&form=6&db=m The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29037569&form=6&db=m Poly(ADP-ribose) polymerase (PARP) inhibitors and ovarian cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29037806&form=6&db=m PARP inhibitors: Clinical utility and possibilities of overcoming resistance. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29040190&form=6&db=m Novel Therapeutics for Ovarian Cancer: The 11th Biennial Rivkin Center Ovarian Cancer Research Symposium. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29063517&form=6&db=m PARP Inhibitors in the Treatment of Triple-Negative Breast Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29072978&form=6&db=m Maintenance Poly (ADP-ribose) Polymerase Inhibitor Therapy for Ovarian Cancer: Precision Oncology or One Size Fits All? therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29086349&form=6&db=m Targeted Therapies in the Management of Ovarian Cancer: A Focus on Older Patients. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29109859&form=6&db=m Candidate synthetic lethality partners to PARP inhibitors in the treatment of ovarian clear cell cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29132681&form=6&db=m [DNA repair as a therapeutic target]. therapeutic application,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29166829&form=6&db=m Rucaparib: A Poly(ADP-Ribose) Polymerase Inhibitor for BRCA-Mutated Relapsed Ovarian Cancer. diagnostic usage,therapeutic application,unassigned 1,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29184090&form=6&db=m Thyroid hormones derivatives reduce proliferation and induce cell death and DNA damage in ovarian cancer. unassigned - 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29186085&form=6&db=m PARP inhibitors for ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29189915&form=6&db=m Targeting BRCA1/2 deficient ovarian cancer with CNDAC-based drug combinations. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29205122&form=6&db=m PARP inhibitors in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29228718&form=6&db=m Increased single-strand annealing rather than non-homologous end-joining predicts hereditary ovarian carcinoma. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29251676&form=6&db=m Frontline therapy of ovarian cancer: trials and tribulations. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29262321&form=6&db=m BET Bromodomain Inhibition Synergizes with PARP Inhibitor in Epithelial Ovarian Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29262611&form=6&db=m PARP inhibition causes premature loss of cohesion in cancer cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29282716&form=6&db=m Targeting DNA repair: the genome as a potential biomarker. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29283581&form=6&db=m Ratio-Dependent Synergism of a Doxorubicin and Olaparib Combination in 2D and Spheroid Models of Ovarian Cancer. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29290694&form=6&db=m Emerging treatment options for ovarian cancer: focus on rucaparib. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29313444&form=6&db=m Poly (ADP-ribose) polymerase inhibitors in the management of ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29322231&form=6&db=m The effect of food on the pharmacokinetics of niraparib, a poly(ADP-ribose) polymerase (PARP) inhibitor, in patients with recurrent ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29327913&form=6&db=m Proteomic Analysis of the Downstream Signaling Network of PARP1. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29340034&form=6&db=m Prexasertib, a cell cycle checkpoint kinases 1 and 2 inhibitor, increases causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29352572&form=6&db=m Phase I combination study of the PARP inhibitor veliparib plus carboplatin and gemcitabine in patients with advanced ovarian cancer and other solid malignancies. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29405820&form=6&db=m The irreversible ERBB1/2/4 inhibitor neratinib interacts with the PARP1 inhibitor niraparib to kill ovarian cancer cells. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29464354&form=6&db=m PARP inhibitors in platinum-sensitive high-grade serous ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29509546&form=6&db=m A PET imaging agent for evaluating PARP-1 expression in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,3 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29511213&form=6&db=m Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29512470&form=6&db=m PARP Inhibitors in Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29521233&form=6&db=m Parp Inhibitors for the Treatment of Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29562224&form=6&db=m PARP (Poly(ADP-Ribose) Polymerase) Inhibitors in Platinum-Sensitive Recurrent Ovarian Cancer: A Meta-Analysis of Randomized Controlled Trials. unassigned - 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29567272&form=6&db=m The BET inhibitor INCB054329 reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29588214&form=6&db=m Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells. causal interaction,unassigned 1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29593098&form=6&db=m Administration of the Tablet Formulation of Olaparib in Patients with Ovarian Cancer: Practical Guidance and Expectations. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29605737&form=6&db=m Rucaparib: An emerging parp inhibitor for treatment of recurrent ovarian cancer. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29615458&form=6&db=m An Effective Epigenetic-PARP inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA-mutations. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29617652&form=6&db=m Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas. therapeutic application,unassigned 2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29627080&form=6&db=m Assessment and management of diarrhea following VEGF receptor TKI treatment in patients with ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29644491&form=6&db=m Update on PARP Inhibitors in Breast Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29650809&form=6&db=m [Molecular Targeted Therapies for Hereditary Cancer Syndrome]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29669295&form=6&db=m A Quantitative Chemotherapy Genetic Interaction Map Reveals Factors Associated with PARP Inhibitor Resistance. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29684820&form=6&db=m Increased oxidative stress mediates the antitumor effect of PARP inhibition in ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29703482&form=6&db=m Anti-angiogenesis for cancer: Current status and prospects. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29750420&form=6&db=m Latest clinical evidence and further development of PARP inhibitors in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29774075&form=6&db=m Plectin-targeted liposomes enhance the therapeutic efficacy of a PARP inhibitor in the treatment of ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29783721&form=6&db=m AZD1775 Increases Sensitivity to Olaparib and Gemcitabine in Cancer Cells with p53 Mutations. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29784743&form=6&db=m New Therapies for Ovarian Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29866945&form=6&db=m The Importance of Distinguishing Sporadic Cancers from Those Related to Cancer Predisposing Germline Mutations. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29867226&form=6&db=m BRCA1/2 testing: therapeutic implications for breast cancer management. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29871906&form=6&db=m PARP Inhibitors in Ovarian Cancer: A Trailblazing and Transformative Journey. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29895102&form=6&db=m The promising PARP inhibitors in ovarian cancer therapy: From Olaparib to others. therapeutic application,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29911447&form=6&db=m Niraparib for the treatment of ovarian cancer. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29955114&form=6&db=m Synthetic lethal therapies for cancer: what's next after PARP inhibitors? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30024813&form=6&db=m The CHK1 inhibitor SRA737 synergizes with PARP1 inhibitors to kill carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30026001&form=6&db=m PARP inhibitors and quality of life in ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30032296&form=6&db=m Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30036195&form=6&db=m Inherited gynaecological cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30050740&form=6&db=m Role of Poly Adenosine Diphosphate Ribose Polymerase Inhibitors in Advanced Stage Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30067614&form=6&db=m Management of newly diagnosed or recurrent ovarian cancer. causal interaction,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30070367&form=6&db=m A case of immune-mediated liver injury induced by Olaparib. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30080919&form=6&db=m Using PARP Inhibitors in Advanced Ovarian Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30092674&form=6&db=m Olaparib for the treatment of relapsed ovarian cancer with a BRCA1/2 mutation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30103829&form=6&db=m BRCA1 and BRCA2 mutations and clinical interpretation in 398 ovarian cancer patients: comparison with breast cancer variants in a similar population. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30105925&form=6&db=m Rucaparib in ovarian cancer: extending the use of PARP inhibitors in the recurrent disease. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30116283&form=6&db=m Advances in the use of PARP inhibitor therapy for breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30127642&form=6&db=m The efficacy and safety of olaparib in the treatment of cancers: a meta-analysis of randomized controlled trials. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30133561&form=6&db=m Homologous recombination deficiency in ovarian cancer: a review of its epidemiology and management. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30177437&form=6&db=m Mechanisms of PARP inhibitor sensitivity and resistance. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30186027&form=6&db=m Poly (ADP-ribose) Polymerase Inhibitors in the Management of Ovarian Cancer: A Drug Class Review. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30215333&form=6&db=m DNA repair proteins as therapeutic targets in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30228165&form=6&db=m Defective DNA repair in hereditary ovarian cancers: Implications for therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30231353&form=6&db=m Moving From Mutation to Actionability. therapeutic application,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30271116&form=6&db=m Risk of selected gastrointestinal toxicities associated with poly (ADP-ribose) polymerase (PARP) inhibitors in the treatment of ovarian cancer: a meta-analysis of published trials. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30278221&form=6&db=m PARP inhibition in platinum-based chemotherapy: Chemopotentiation and neuroprotection. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30293710&form=6&db=m The Era of PARP inhibitors in ovarian cancer: "Class Action" or not? A systematic review and meta-analysis. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30306576&form=6&db=m Targeted therapy for gynecologic cancers: Toward the era of precision medicine. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30333088&form=6&db=m PARP inhibitors in older patients with ovarian and breast cancer: Young International Society of Geriatric Oncology review paper. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30342021&form=6&db=m Evaluating the potential of kinase inhibitors to suppress DNA repair and sensitise ovarian cancer cells to PARP inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30353044&form=6&db=m Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30401677&form=6&db=m PARP1 Suppresses the Transcription of PD-L1 by Poly(ADP-Ribosyl)ating STAT3. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30401718&form=6&db=m PARP Inhibition Induces Enrichment of DNA Repair-Proficient CD133 and CD117 Positive Ovarian Cancer Stem Cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30407325&form=6&db=m Response of germline BRCA2-mutated advanced pancreatic acinar cell carcinoma to olaparib: A case report. causal interaction,unassigned 1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30417796&form=6&db=m Poly (ADP-Ribose) Polymerases (PARPs) and PARP Inhibitor-Targeted Therapeutics. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30426062&form=6&db=m Pharmacokinetics and clinical response to single agent rucaparib in a dialysis dependent patient with BRCA associated breast and recurrent ovarian cancer. unassigned - 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30429212&form=6&db=m PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30449210&form=6&db=m How safe is rucaparib in ovarian cancer? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30451713&form=6&db=m Update in the use and evaluation of poly (ADP-ribose) polymerase inhibitors in epithelial ovarian cancer: current and pending clinical research. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30466807&form=6&db=m Identifying the need to refine the potential patient risk factors for niraparib-induced thrombocytopenia. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30479195&form=6&db=m Cost-Effectiveness of Niraparib and Olaparib as Maintenance Therapy for Patients with Platinum-Sensitive Recurrent Ovarian Cancer. causal interaction,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30518089&form=6&db=m Role of BRCA Mutations in Cancer Treatment with Poly(ADP-ribose) Polymerase (PARP) Inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30535808&form=6&db=m Using PARP Inhibitors in the Treatment of Patients With Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30540581&form=6&db=m Poly-ADP-ribosyl-polymerase inhibitor resistance mechanisms and their therapeutic implications. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30540933&form=6&db=m PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30543930&form=6&db=m PARP inhibitors in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30551885&form=6&db=m Chemotherapy and PARP inhibitors in heavily pretreated BRCA1/2 mutation ovarian cancer (BMOC) patients. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30555227&form=6&db=m Intraperitoneal delivery of NanoOlaparib for disseminated late-stage cancer treatment. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30576872&form=6&db=m Combined Targeted Resequencing of Cytosine DNA Methylation and Mutations of DNA Repair Genes with Potential Use for Poly(ADP-Ribose) Polymerase 1 Inhibitor Sensitivity Testing. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30614472&form=6&db=m Exploring and comparing adverse events between PARP inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30630446&form=6&db=m Sequential therapeutic targeting of ovarian Cancer harboring dysfunctional BRCA1. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30672100&form=6&db=m PARP inhibitors in ovarian cancer: Sensitivity prediction and resistance mechanisms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30684797&form=6&db=m Medicinal chemistry approaches of poly ADP-Ribose polymerase 1 (PARP1) inhibitors as anticancer agents - A recent update. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30686551&form=6&db=m 53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30686591&form=6&db=m Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30691488&form=6&db=m Current strategies for the targeted treatment of high-grade serous epithelial ovarian cancer and relevance of BRCA mutational status. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30695681&form=6&db=m New developments in molecular targeted therapy of ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30712944&form=6&db=m SPSB1 enhances ovarian cancer cell survival by destabilizing p21. causal interaction,diagnostic usage,unassigned 4,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30737031&form=6&db=m Novel pharmacological effects of poly (ADP-ribose) polymerase inhibitor rucaparib on the lactate dehydrogenase pathway. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30740957&form=6&db=m Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30741937&form=6&db=m NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30755715&form=6&db=m Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30797591&form=6&db=m ERCC1-XPF deficiency is a predictor of olaparib induced synthetic lethality and platinum sensitivity in epithelial ovarian cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30806045&form=6&db=m Major clinical research advances in gynecologic cancer in 2018. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30824778&form=6&db=m PARP1 rs1805407 Increases Sensitivity to PARP1 Inhibitors in Cancer Cells Suggesting an Improved Therapeutic Strategy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30854033&form=6&db=m Combinatorial therapy of immune checkpoint and cancer pathways provides a novel perspective on ovarian cancer treatment. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30870286&form=6&db=m U.S. Food and Drug Administration-Approved Poly (ADP-Ribose) Polymerase Inhibitor Maintenance Therapy for Recurrent Ovarian Cancer: A Cost-Effectiveness Analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30876487&form=6&db=m Targeted composite value-based endpoints in platinum-sensitive recurrent ovarian cancer. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30880068&form=6&db=m Extending the scope of PARP inhibitors in ovarian cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30889383&form=6&db=m DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30895466&form=6&db=m PARP Inhibitors and the Evolving Landscape of Ovarian Cancer Management: A Review. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30898650&form=6&db=m MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30912451&form=6&db=m Advances in the use of PARP inhibitors for BRCA1/2-associated breast cancer: talazoparib. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30923663&form=6&db=m Single-particle analysis of full-length human poly(ADP-ribose) polymerase 1. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30926640&form=6&db=m GnRH-R-Targeted Lytic Peptide Sensitizes BRCA Wild-type Ovarian Cancer to PARP Inhibition. therapeutic application,unassigned 1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30948273&form=6&db=m Niraparib monotherapy for late-line treatment of ovarian cancer (QUADRA): a multicentre, open-label, single-arm, phase 2 trial. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30949414&form=6&db=m Synergism of PARP inhibitor fluzoparib (HS10160) and MET inhibitor HS10241 in breast and ovarian cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30977683&form=6&db=m Rucaparib in the landscape of PARP inhibition in ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30979685&form=6&db=m Combining PARP and CDK4/6 inhibitors in MYC driven ovarian cancer. therapeutic application,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30988514&form=6&db=m Detecting the mutational signature of homologous recombination deficiency in clinical samples. causal interaction,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30998513&form=6&db=m Poly (ADP-ribose) polymerase inhibitors combined with other small-molecular compounds for the treatment of ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31002019&form=6&db=m Pancreatic acinar cell carcinoma is associated with BRCA2 germline mutations: a case report and literature review. ongoing research,unassigned 1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31050911&form=6&db=m Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31069647&form=6&db=m Current Systemic Treatment Landscape of Advanced Gynecologic Malignancies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31092693&form=6&db=m Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31099635&form=6&db=m The DNA Damaging Revolution: PARP Inhibitors and Beyond. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31103013&form=6&db=m A label-free PFP-based photoelectrochemical biosensor for highly sensitive detection of PARP-1 activity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31109041&form=6&db=m PARP Inhibitors in Ovarian Cancer: The Route to "Ithaca". causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31114351&form=6&db=m Efficacy and safety of olaparib maintenance therapy in platinum-sensitive ovarian cancer patients with BRCA mutations: a meta-analysis on randomized controlled trials. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31116084&form=6&db=m DNA double-strand break repair pathway choice - from basic biology to clinical exploitation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31117037&form=6&db=m New Therapies for Ovarian Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31118216&form=6&db=m Poly-ADP-ribose polymerase inhibitor use in ovarian cancer: expanding indications and novel combination strategies. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31126961&form=6&db=m Advancing Drug Development in Gynecologic Malignancies. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31130614&form=6&db=m Immune System and DNA Repair Defects in Ovarian Cancer: Implications for Locoregional Approaches. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31134152&form=6&db=m Nanoformulation of Talazoparib Delays Tumor Progression and Ascites Formation in a Late Stage Cancer Model. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31173551&form=6&db=m Niraparib Maintenance Therapy in Patients With Recurrent Ovarian Cancer After a Partial Response to the Last Platinum-Based Chemotherapy in the ENGOT-OV16/NOVA Trial. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31176273&form=6&db=m Recommendations for the implementation of BRCA testing in ovarian cancer patients and their relatives. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31186408&form=6&db=m Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence. therapeutic application,unassigned 1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31191001&form=6&db=m Current status and future prospects of PARP inhibitor clinical trials in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31200086&form=6&db=m Evaluation of the epidemiological and prognosis significance of ESR2 rs3020450 polymorphism in ovarian cancer. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31205507&form=6&db=m Olaparib as maintenance treatment for patients with platinum-sensitive relapsed ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31218365&form=6&db=m A decade of clinical development of PARP inhibitors in perspective. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31242303&form=6&db=m PARP inhibitors for BRCA wild type ovarian cancer; gene alterations, homologous recombination deficiency and combination therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31242618&form=6&db=m Identification of Novel Biomarkers of Homologous Recombination Defect in DNA Repair to Predict Sensitivity of Prostate Cancer Cells to PARP-Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31249881&form=6&db=m Layer-by-layer nanoparticles for novel delivery of cisplatin and PARP inhibitors for platinum-based drug resistance therapy in ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31264436&form=6&db=m Genomic-Based Therapy of Gynecologic Malignancies. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31267481&form=6&db=m Pharmaceutical Management of Ovarian Cancer: Current Status. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31303961&form=6&db=m PARP-1 inhibitor modulate ?-catenin signaling to enhance cisplatin sensitivity in cancer cervix. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31329989&form=6&db=m Synthetic lethality between BRCA1 deficiency and poly(ADP-ribose) polymerase inhibition is modulated by processing of endogenous oxidative DNA damage. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31335830&form=6&db=m Current role of poly(ADP-ribose) polymerase inhibitors: which poly(ADP-ribose) polymerase inhibitor and when? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31374917&form=6&db=m Combined Strategies with Poly (ADP-Ribose) Polymerase (PARP) Inhibitors for the Treatment of Ovarian Cancer: A Literature Review. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31381953&form=6&db=m Diverse mechanisms of PARP inhibitor resistance in ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31409614&form=6&db=m The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP Inhibition. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31449760&form=6&db=m Defining and targeting wild-type BRCA high-grade serous ovarian cancer: DNA repair and cell cycle checkpoints. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31462544&form=6&db=m Novel therapeutics: response and resistance in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31474356&form=6&db=m Combined PARP and Immune Checkpoint Inhibition in Ovarian Cancer. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31500199&form=6&db=m The Role of PARPs in Inflammation-and Metabolic-Related Diseases: Molecular Mechanisms and Beyond. causal interaction,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31534014&form=6&db=m ALDH1A1 contributes to PARP inhibitor resistance via enhancing DNA repair in BRCA2-/- ovarian cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31537627&form=6&db=m Next-generation sequencing-based BRCA testing on cytological specimens from ovarian cancer ascites reveals high concordance with tumour tissue analysis. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31553234&form=6&db=m Olaparib maintenance monotherapy in platinum-sensitive, relapsed ovarian cancer without germline BRCA mutations: OPINION Phase IIIb study design. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31553293&form=6&db=m Advances in the Treatment of Ovarian Cancer Using PARP Inhibitors and the Underlying Mechanism of Resistance. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31565603&form=6&db=m Molecular Testing Identifies Determinants of Exceptional Response and Guides Precision Therapy in a Patient with Lethal, Treatment-emergent Neuroendocrine Prostate Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31570282&form=6&db=m BRCA1/2 somatic mutation detection in formalin-fixed paraffin embedded tissue by next-generation sequencing in Korean ovarian cancer patients. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31575654&form=6&db=m Amplification of the Mutation-Carrying BRCA2 Allele Promotes RAD51 Loading and PARP Inhibitor Resistance in the Absence of Reversion Mutations. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31590683&form=6&db=m Epigenetic synthetic lethality approaches in cancer therapy. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31591108&form=6&db=m Success for First-Line PARP Inhibition in Ovarian Cancer. diagnostic usage,therapeutic application,unassigned 2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31594824&form=6&db=m ADP-Ribosylation Levels and Patterns Correlate with Gene Expression and Clinical Outcomes in Ovarian Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31599396&form=6&db=m Comparison of PARPis with Angiogenesis Inhibitors and Chemotherapy for Maintenance in Ovarian Cancer: A Network Meta-Analysis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31625002&form=6&db=m PARP Inhibition in Cancer: An Update on Clinical Development. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31627702&form=6&db=m Synthetic Lethality - Its Current Application and Potential in Oncological Treatment. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31629204&form=6&db=m Parp inhibitors as maintenance treatment in platinum sensitive recurrent ovarian cancer: An updated meta-analysis of randomized clinical trials according to BRCA mutational status. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31630846&form=6&db=m Choosing wisely: Selecting PARP inhibitor combinations to promote anti-tumor immune responses beyond BRCA mutations. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31640753&form=6&db=m Mapping genetic interactions in cancer: a road to rational combination therapies. diagnostic usage,unassigned 1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31669203&form=6&db=m PARP1 blockade is synthetically lethal in XRCC1 deficient sporadic epithelial ovarian cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31685558&form=6&db=m Antitumor activity of the poly(ADP-ribose) polymerase inhibitor rucaparib as monotherapy in patients with platinum-sensitive, relapsed, BRCA-mutated, high-grade ovarian cancer, and an update on safety. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31700176&form=6&db=m PARP inhibitors for all ovarian cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31714594&form=6&db=m Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts, and patient-derived xenograft models. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31722968&form=6&db=m Let-7e Suppresses DNA Damage Repair and Sensitizes Ovarian Cancer to Cisplatin through Targeting PARP1. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31742824&form=6&db=m Prevalence of hereditary breast and ovarian cancer (HBOC) predisposition gene mutations among 882 HBOC high-risk Chinese individuals. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31744639&form=6&db=m Corrigendum to 'Chemotherapy and PARP inhibitors in heavily pretreated BRCA1/2 mutation ovarian cancer (BMOC) patients' [Gynecologic Oncology 152 (2019) 270-277]. unassigned - 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31753490&form=6&db=m Non-small cell lung cancer cells with deficiencies in homologous recombination genes are sensitive to PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31775908&form=6&db=m Olaparib in the therapy of advanced ovarian cancer: first real world experiences in safety and efficacy from China. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31780705&form=6&db=m Germline and somatic mutations of homologous recombination-associated genes in Japanese ovarian cancer patients. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31795418&form=6&db=m A Small Compound KJ-28d Enhances the Sensitivity of Non-Small Cell Lung Cancer to Radio- and Chemotherapy. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31815182&form=6&db=m Response to Olaparib in a Patient with Germline BRCA2 Mutation and Breast Cancer Leptomeningeal Carcinomatosis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31815769&form=6&db=m Mechanisms of PARP inhibitor resistance in ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31846530&form=6&db=m Targeted therapies in gynaecological cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31857852&form=6&db=m Crizotinib and PARP inhibitors act synergistically by triggering apoptosis in high-grade serous ovarian cancer. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31865042&form=6&db=m Circulating HOXA9-methylated tumour DNA: A novel biomarker of response to poly (ADP-ribose) polymerase inhibition in BRCA-mutated epithelial ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31875860&form=6&db=m Translational Highlights in Breast and Ovarian Cancer 2019 - Immunotherapy, DNA Repair, PI3K Inhibition and CDK4/6 Therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31883617&form=6&db=m The influence of long non-coding RNAs on the response to chemotherapy in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31907386&form=6&db=m Impact of proactive high-throughput functional assay data on BRCA1 variant interpretation in 3684 patients with breast or ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,3 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31920338&form=6&db=m Role of Olaparib as Maintenance Treatment for Ovarian Cancer: The Evidence to Date. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31931287&form=6&db=m Mechanism and current progress of Poly ADP-ribose polymerase (PARP) inhibitors in the treatment of ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31949706&form=6&db=m Potential role of HGF-PARP-1 signaling in invasion of ovarian cancer cells. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31955565&form=6&db=m Nobiletin Triggers Reactive Oxygen Species-Mediated Pyroptosis through Regulating Autophagy in Ovarian Cancer Cells. causal interaction,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31982178&form=6&db=m Patient preferences for maintenance PARP inhibitor therapy in ovarian cancer treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31987601&form=6&db=m Expression of PD-L1 in ovarian cancer and its synergistic antitumor effect with PARP inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32004442&form=6&db=m EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition. therapeutic application,unassigned 2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32005272&form=6&db=m MiR-509-3 augments the synthetic lethality of PARPi by regulating HR repair in PDX model of HGSOC. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32018126&form=6&db=m Magnitude of benefit of the addition of poly ADP-ribose polymerase (PARP) inhibitors to therapy for malignant tumor: A meta-analysis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32028808&form=6&db=m A profile on the FoundationFocus CDxBRCA tests. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32030362&form=6&db=m PARP Inhibitors in Pancreatic Cancer: From Phase I to Plenary Session. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32048043&form=6&db=m Sharing real-world experiences to optimize the management of olaparib toxicities: a practical guidance from an Italian expert panel. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32051558&form=6&db=m First-line PARP inhibition in ovarian cancer - standard of care for all? therapeutic application,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32079709&form=6&db=m Decision analysis for secondline maintenance treatment of platinum sensitive recurrent ovarian cancer: a review. therapeutic application,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32096544&form=6&db=m Efficacy and safety of PARP inhibitors as the maintenance therapy in ovarian cancer: a meta-analysis of nine randomized controlled trials. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32098452&form=6&db=m Olaparib Combined with an ATR or Chk1 Inhibitor as a Treatment Strategy for Acquired Olaparib-Resistant BRCA1 Mutant Ovarian Cells. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32098980&form=6&db=m Oncologist-led BRCA 'mainstreaming' in the ovarian cancer clinic: A study of 255 patients and its impact on their management. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32121331&form=6&db=m The Development of Rucaparib/Rubraca®: A Story of the Synergy Between Science and Serendipity. diagnostic usage,unassigned 1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32124385&form=6&db=m Somatic mRNA Analysis of BRCA1 Splice Variants Provides a Direct Theranostic Impact on PARP Inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32135515&form=6&db=m Exceptional Response to Olaparib in a Patient With Recurrent Ovarian Cancer and an Entire BRCA1 Germline Gene Deletion. causal interaction,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32164505&form=6&db=m A Review on Poly (ADP-ribose) Polymerase (PARP) Inhibitors and Synthetic Methodologies. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32164585&form=6&db=m Mutation landscape of germline and somatic BRCA1/2 in patients with high-grade serous ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32166978&form=6&db=m Poly(ADP-ribose) polymerase inhibitors as maintenance treatment in patients with newly diagnosed advanced ovarian cancer: a meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32172572&form=6&db=m Niraparib for the Treatment of Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32180937&form=6&db=m The role of poly(ADP-ribose) polymerase inhibitors in the treatment of cancer and methods to overcome resistance: a review. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32181758&form=6&db=m [Medical treatment options in BRCA-associated cancers]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32183851&form=6&db=m Tumor burden is a potential marker of PARP inhibitor effects in ovarian cancer: a head-to-head observational series. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32186787&form=6&db=m [PARP INHIBITORS FOR ADJUVANT TREATMENT FOR OVARIAN CANCER]. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32193378&form=6&db=m Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32212132&form=6&db=m PARP Inhibitors as Frontline Treatment in Patients With Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32215876&form=6&db=m Poly (ADP-Ribose) Polymerase Inhibitors: Talazoparib in Ovarian Cancer and Beyond. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32218813&form=6&db=m Pharmacological ascorbate induces 'BRCAness' and enhances the effects of Poly(ADP-Ribose) polymerase inhibitors against BRCA1/2 wild-type ovarian cancer. therapeutic application,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32221289&form=6&db=m Differential regulation of breast cancer bone metastasis by PARP1 and PARP2. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32222339&form=6&db=m Synthesis of novel dual target inhibitors of PARP and HSP90 and their antitumor activities. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32272732&form=6&db=m Ovarian Cancer Translational Activity of the Multicenter Italian Trial in Ovarian Cancer (MITO) Group: Lessons Learned in 10 Years of Experience. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32276934&form=6&db=m Manage wisely: poly (ADP-ribose) polymerase inhibitor (PARPi) treatment and adverse events. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32294361&form=6&db=m PARP Inhibitors in Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32294362&form=6&db=m PARP Inhibitors in Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32294363&form=6&db=m PARP Inhibitors in Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32294364&form=6&db=m PARP Inhibitors in Ovarian Cancer. Reply. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32294365&form=6&db=m PARP Inhibitors in Ovarian Cancer. Reply. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32319232&form=6&db=m Major clinical research advances in gynecologic cancer in 2019. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32364757&form=6&db=m PARP Inhibitors for Ovarian Cancer: Current Indications, Future Combinations, and Novel Assets in Development to Target DNA Damage Repair. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32368391&form=6&db=m CDK9 inhibitor CDKI-73 is synergetic lethal with PARP inhibitor olaparib in BRCA1 wide-type ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32392113&form=6&db=m Strategic Combination Therapies for Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32398324&form=6&db=m Combination of PARP Inhibitor Olaparib, and PD-L1 Inhibitor Durvalumab, in Recurrent Ovarian Cancer: a Proof-of-Concept Phase II Study. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32403357&form=6&db=m Exploiting the Prevalence of Homologous Recombination Deficiencies in High-Grade Serous Ovarian Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32422564&form=6&db=m Therapeutic applications of PARP inhibitors in ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32424117&form=6&db=m Author Correction: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer. therapeutic application,unassigned 2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32444417&form=6&db=m EVOLVE: A Multicenter Open-Label Single-Arm Clinical and Translational Phase II Trial of Cediranib Plus Olaparib for Ovarian Cancer after PARP Inhibition Progression. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32450190&form=6&db=m PARP inhibition in the ovarian cancer patient: Current approvals and future directions. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32454030&form=6&db=m Chemotherapy directly followed by poly(ADP-ribose) polymerase inhibition as an alternative to surgery in patients with BRCA-mutated ovarian cancer: a potential management strategy in the era of coronavirus disease 2019. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32454976&form=6&db=m Long-term response to Olaparib in carcinomatous meningitis of a BRCA2 mutated ovarian cancer: A case report. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32457376&form=6&db=m CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32468256&form=6&db=m High resolution melting profiles (HRMPs) obtained by magnetic induction cycler (MIC) have been used to monitor the BRCA2 status highlighted by next generation tumor sequencing (NGTS): a combined approach in a diagnostic environment. causal interaction,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32471250&form=6&db=m Bevacizumab or PARP-Inhibitors Maintenance Therapy for Platinum-Sensitive Recurrent Ovarian Cancer: A Network Meta-Analysis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32482307&form=6&db=m PARP goes the weasel! Emerging role of PARP inhibitors in acute leukemias. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32486089&form=6&db=m Consolidated BRCA1/2 Variant Interpretation by MH BRCA Correlates with Predicted PARP Inhibitor Efficacy Association by MH Guide. diagnostic usage,unassigned 2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32495160&form=6&db=m Management of Adverse Events During Rucaparib Treatment for Relapsed Ovarian Cancer: A Review of Published Studies and Practical Guidance. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32523631&form=6&db=m Practical guidance for the management of side effects during rucaparib therapy in a multidisciplinary UK setting. diagnostic usage,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32526907&form=6&db=m Identifying and Overcoming Mechanisms of PARP Inhibitor Resistance in Homologous Recombination Repair-Deficient and Repair-Proficient High Grade Serous Ovarian Cancer Cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32555285&form=6&db=m Antitumor effect of a WEE1 inhibitor and potentiation of olaparib sensitivity by DNA damage response modulation in triple-negative breast cancer. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32563252&form=6&db=m PARP inhibitor resistance: the underlying mechanisms and clinical implications. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32568634&form=6&db=m Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors. diagnostic usage,therapeutic application,unassigned 1,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32569489&form=6&db=m Emerging drugs for the treatment of ovarian cancer: a focused review of PARP inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32569725&form=6&db=m The forefront of ovarian cancer therapy: update on PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32571890&form=6&db=m Exploiting replicative stress in gynecological cancers as a therapeutic strategy. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32594311&form=6&db=m The Prognostic Value of PARP Expression in High-Grade Epithelial Ovarian Cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32596142&form=6&db=m PARP Inhibitors in First-Line Therapy of Ovarian Cancer: Are There Any Doubts? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32609666&form=6&db=m The role of PARP inhibitors in germline BRCA-associated pancreatic ductal adenocarcinoma. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32612955&form=6&db=m Efficacy and Prognostic Factors for PARP Inhibitors in Patients With Ovarian Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32622363&form=6&db=m The efficacy and safety of the addition of poly ADP-ribose polymerase (PARP) inhibitors to therapy for ovarian cancer: a systematic review and meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32640708&form=6&db=m Advancements in PARP1 Targeted Nuclear Imaging and Theranostic Probes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32644177&form=6&db=m Further Analyses Highlight Benefits of PARP Inhibitors As Frontline Maintenance in Ovarian Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32652753&form=6&db=m Successful Treatment of Patients with Refractory High-Grade Serous Ovarian Cancer with GOPC-ROS1 Fusion Using Crizotinib: A Case Report. causal interaction,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32654312&form=6&db=m PARP inhibitors as maintenance therapy in newly diagnosed advanced ovarian cancer: a meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32679669&form=6&db=m The Landscape and Therapeutic Implications of Molecular Profiles in Epithelial Ovarian Cancer. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32709856&form=6&db=m Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32717529&form=6&db=m The ups and downs of Poly(ADP-ribose) Polymerase-1 inhibitors in cancer therapy-Current progress and future direction. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32724113&form=6&db=m Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing. causal interaction,diagnostic usage,unassigned 2,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32726747&form=6&db=m Augmentation of the antitumor effects of PARP inhibitors in triple-negative breast cancer via degradation by hydrophobic tagging modulation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32755579&form=6&db=m The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32770700&form=6&db=m Front-line ovarian cancer maintenance therapy: PARP inhibitors for all? therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32778410&form=6&db=m Frontline PARP inhibitor maintenance therapy in ovarian cancer: A Society of Gynecologic Oncology practice statement. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32787340&form=6&db=m Controversies on the treatment of ovarian cancer with dose-dense chemotherapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32790492&form=6&db=m PARP Inhibitors in the Management of Ovarian Cancer: ASCO Guideline. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32794041&form=6&db=m A Critical Appraisal and Recommendations for Cost-Effectiveness Studies of Poly(ADP-Ribose) Polymerase Inhibitors in Advanced Ovarian Cancer. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32796232&form=6&db=m Role of Poly (ADP-Ribose) Polymerase inhibitors beyond BReast CAncer Gene-mutated ovarian tumours: definition of homologous recombination deficiency? causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32817083&form=6&db=m Poly (ADP-ribose) polymerase (PARP) inhibitor regimens for ovarian cancer in phase III randomized controlled trials: a network meta-analysis. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32819110&form=6&db=m PARP inhibitors in ovarian cancer: evidence for maintenance and treatment strategies. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32833070&form=6&db=m Overcoming PARP inhibitor resistance in ovarian cancer: what are the most promising strategies? causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32850351&form=6&db=m PARP Inhibitors in Patients With Newly Diagnosed Advanced Ovarian Cancer: A Meta-Analysis of Randomized Clinical Trials. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32852746&form=6&db=m Movement of Poly-ADP Ribose (PARP) Inhibition into Frontline Treatment of Ovarian Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32859605&form=6&db=m Inhibition of the MYC-regulated glutaminase metabolic axis is an effective synthetic lethal approach for treating chemoresistant cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32861537&form=6&db=m The effect of age on efficacy, safety and patient-centered outcomes with rucaparib: A post hoc exploratory analysis of ARIEL3, a phase 3, randomized, maintenance study in patients with recurrent ovarian carcinoma. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32863036&form=6&db=m Cost-effectiveness analysis comparing "PARP inhibitors-for-all" to the biomarker-directed use of PARP inhibitor maintenance therapy for newly diagnosed advanced stage ovarian cancer. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32878963&form=6&db=m DUETTE: a phase II randomized, multicenter study to investigate the efficacy and tolerability of a second maintenance treatment in patients with platinum-sensitive relapsed epithelial ovarian cancer, who have previously received poly(ADP-ribose) polymerase (PARP) inhibitor maintenance treatment. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32880196&form=6&db=m Niraparib in the treatment of previously treated advanced ovarian, fallopian tube or primary peritoneal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32884343&form=6&db=m NEAT1 Knockdown Suppresses the Cisplatin Resistance in Ovarian Cancer by Regulating miR-770-5p/PARP1 Axis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32927276&form=6&db=m BET, SRC, and BCL2 family inhibitors are synergistic drug combinations with PARP inhibitors in ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32941897&form=6&db=m Application and reflection of genomic scar assays in evaluating the efficacy of platinum salts and PARP inhibitors in cancer therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32944622&form=6&db=m Targeting CARM1 in ovarian cancer with EZH2 and PARP inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32958271&form=6&db=m A first-in-class CDK4 inhibitor demonstrates in vitro, ex-vivo and in vivo efficacy against ovarian cancer. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32972786&form=6&db=m Management of nausea and vomiting from poly(ADP-ribose) polymerase inhibitor therapy for advanced ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32977221&form=6&db=m Concordance between CA-125 and RECIST progression in patients with germline BRCA-mutated platinum-sensitive relapsed ovarian cancer treated in the SOLO2 trial with olaparib as maintenance therapy after response to chemotherapy. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32981695&form=6&db=m Long-term safety in patients with recurrent ovarian cancer treated with niraparib versus placebo: Results from the phase III ENGOT-OV16/NOVA trial. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33004253&form=6&db=m ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33006584&form=6&db=m PARP inhibition as frontline therapy in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33008098&form=6&db=m Gene Panel Tumor Testing in Ovarian Cancer Patients Significantly Increases the Yield of Clinically Actionable Germline Variants beyond BRCA1/BRCA2. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014878&form=6&db=m RECQL4, Negatively Regulated by miR-10a-5p, Facilitates Cell Proliferation and Invasion via MAFB in Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33015058&form=6&db=m PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33017510&form=6&db=m FDA Approval Summary: Olaparib Monotherapy or in Combination with Bevacizumab for the Maintenance Treatment of Patients with Advanced Ovarian Cancer. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33032822&form=6&db=m Inhibition of poly(ADP-ribose) polymerase induces synthetic lethality in BRIP1 deficient ovarian epithelial cells. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33040627&form=6&db=m Emerging role of immune checkpoint inhibitors in the treatment of ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33055011&form=6&db=m The current landscape of molecular profiling in the treatment of epithelial ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33058112&form=6&db=m Using PARP Inhibitors in Frontline Maintenance Therapy for Ovarian Cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33059228&form=6&db=m The DNA damaging revolution. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33061301&form=6&db=m Anti-Tumor Xanthones from Garcinia nujiangensis Suppress Proliferation, and Induce Apoptosis via PARP, PI3K/AKT/mTOR, and MAPK/ERK Signaling Pathways in Human Ovarian Cancers Cells. ongoing research,unassigned 1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33081005&form=6&db=m Comparison of Poly (ADP-ribose) Polymerase Inhibitors (PARPis) as Maintenance Therapy for Platinum-Sensitive Ovarian Cancer: Systematic Review and Network Meta-Analysis. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33190931&form=6&db=m Lived experiences of women reporting fatigue during PARP inhibitor maintenance treatment for advanced ovarian cancer: A qualitative study. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33198203&form=6&db=m BRCA in Gastrointestinal Cancers: Current Treatments and Future Perspectives. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33201871&form=6&db=m PARP inhibition in recurrent ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33233320&form=6&db=m Therapeutic Potential of PARP Inhibitors in the Treatment of Metastatic Castration-Resistant Prostate Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33235908&form=6&db=m CX-5461 can destabilize replication forks in PARP inhibitor-resistant models of ovarian cancer. unassigned - 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33250205&form=6&db=m Olaparib maintenance therapy in patients with newly diagnosed advanced ovarian cancer and a BRCA1 and/or BRCA2 mutation: SOLO1 China cohort. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33254040&form=6&db=m Efficacy and safety of PARP inhibitors in the treatment of advanced ovarian cancer: An updated systematic review and meta-analysis of randomized controlled trials. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33310779&form=6&db=m First-line PARP inhibitors in ovarian cancer: summary of an ESMO Open - Cancer Horizons round-table discussion. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33332934&form=6&db=m Enhanced Efficacy of Combined Therapy with Checkpoint Kinase 1 Inhibitor and Rucaparib Via Regulation of Rad-51 Expression in BRCA Wild-Type Epithelial Ovarian Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33343988&form=6&db=m Rucaparib and Niraparib in Advanced Ovarian Cancer. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33347814&form=6&db=m Myelodysplastic syndrome and acute myeloid leukaemia in patients treated with PARP inhibitors: a safety meta-analysis of randomised controlled trials and a retrospective study of the WHO pharmacovigilance database. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33352773&form=6&db=m PARP Theranostic Auger Emitters Are Cytotoxic in BRCA Mutant Ovarian Cancer and Viable Tumors from Ovarian Cancer Patients Enable Ex-Vivo Screening of Tumor Response. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33353406&form=6&db=m Managing recurrent ovarian cancer in daily clinical practice: case studies and evidence review with a focus on the use of trabectedin. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33360300&form=6&db=m MicroRNA-506-3p increases the response to PARP inhibitors and cisplatin by targeting EZH2/?-catenin in serous ovarian cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33369580&form=6&db=m PARP inhibitors in the treatment of ovarian cancer: a review. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33369704&form=6&db=m Phase I Study of Rucaparib in Combination with Bevacizumab in Ovarian Cancer Patients: Maximum Tolerated Dose and Pharmacokinetic Profile. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33375989&form=6&db=m Total and out-of-pocket costs for PARP inhibitors among insured ovarian cancer patients. therapeutic application,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33376347&form=6&db=m Niraparib as Maintenance Therapy in Germline ATM-mutated and Somatic BRCA2-mutated Ovarian Cancer with Brain Metastases: A Case Report and Literature Review. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33382149&form=6&db=m PARP inhibitors in ovarian cancer: An overview of the practice-changing trials. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33391423&form=6&db=m The Association of Polymorphisms in Base Excision Repair Genes with Ovarian Cancer Susceptibility in Chinese Women: A Two-Center Case-Control Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33412559&form=6&db=m Modulation of Early Mitotic Inhibitor 1 (EMI1) depletion on the sensitivity of PARP inhibitors in BRCA1 mutated triple-negative breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33414026&form=6&db=m The financial burden of PARP inhibitors on patients, payors, and financial assistance programs: Who bears the cost? ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33453391&form=6&db=m Niraparib maintenance therapy in patients with platinum-sensitive recurrent ovarian cancer using an individualized starting dose (NORA): a randomized, double-blind, placebo-controlled phase III trial?. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33468703&form=6&db=m Stenoparib, an Inhibitor of Cellular Poly(ADP-Ribose) Polymerase, Blocks Replication of the SARS-CoV-2 and HCoV-NL63 Human Coronaviruses In Vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33469840&form=6&db=m Clinical perspectives of BET inhibition in ovarian cancer. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33475085&form=6&db=m Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33478135&form=6&db=m The Prognostic Relevance of Poly (ADP-Ribose) Polymerase Expression in Ovarian Cancer Tissue of Wild Type and BRCA-Mutation Carrier Patients. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33490218&form=6&db=m Development of new poly(ADP-ribose) polymerase (PARP) inhibitors in ovarian cancer: Quo Vadis? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33515422&form=6&db=m SEOM clinical guideline in ovarian cancer (2020). therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33524442&form=6&db=m DNA replication stress and emerging prospects for PARG inhibitors in ovarian cancer therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33575078&form=6&db=m CDCA8, targeted by MYBL2, promotes malignant progression and olaparib insensitivity in ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33596189&form=6&db=m When in the treatment continuum to use PARP inhibition in ovarian cancer. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33607245&form=6&db=m Can integrative biomarker approaches improve prediction of platinum and PARP inhibitor response in ovarian cancer? causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33674744&form=6&db=m Molecular disruption of DNA polymerase ? for platinum sensitisation and synthetic lethality in epithelial ovarian cancers. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33675937&form=6&db=m The systemic treatment of recurrent ovarian cancer revisited. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33684965&form=6&db=m Systematic inhibitor selectivity between PARP1 and PARP2 enzymes: Molecular implications for ovarian cancer personalized therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33691564&form=6&db=m Niraparib in the maintenance treatment of advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer: safety and efficacy. diagnostic usage,therapeutic application,unassigned 2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33692936&form=6&db=m Comparative Efficacy and Safety of PARP Inhibitors as Maintenance Therapy in Platinum Sensitive Recurrent Ovarian Cancer: A Network Meta-Analysis. therapeutic application,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33705352&form=6&db=m PARP inhibitors in breast and ovarian cancer with BRCA mutations: a meta-analysis of survival. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33722571&form=6&db=m PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33740125&form=6&db=m Efficacy and safety of anti-PD-1-based therapy in combination with PARP inhibitors for patients with advanced solid tumors in a real-world setting. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33740262&form=6&db=m Molecular and clinical predictors of improvement in progression-free survival with maintenance PARP inhibitor therapy in women with platinum-sensitive, recurrent ovarian cancer: A meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33743851&form=6&db=m Olaparib tablets as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a final analysis of a double-blind, randomised, placebo-controlled, phase 3 trial. diagnostic usage,therapeutic application,unassigned 2,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33752410&form=6&db=m Adverse events of PARP inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33784003&form=6&db=m LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination-mediated DNA double strand break repair. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33803954&form=6&db=m Ovarian Cancer Treatments Strategy: Focus on PARP Inhibitors and Immune Check Point Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33804647&form=6&db=m Genomic, Transcriptomic, and Functional Alterations in DNA Damage Response Pathways as Putative Biomarkers of Chemotherapy Response in Ovarian Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33850183&form=6&db=m In silico screening identifies a novel small molecule inhibitor that counteracts PARP inhibitor resistance in ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33852339&form=6&db=m PARP Inhibitor in Platinum-Resistant Ovarian Cancer: Single-Center Real-World Experience. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33854565&form=6&db=m ATR and p-ATR are emerging prognostic biomarkers and DNA damage response targets in ovarian cancer. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33857404&form=6&db=m The dystonia gene THAP1 controls DNA double-strand break repair choice. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33882241&form=6&db=m PARP inhibitors and immunotherapy in ovarian and endometrial cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33894017&form=6&db=m A Population Pharmacokinetic Meta-Analysis of Veliparib, a PARP Inhibitor, Across Phase 1/2/3 Trials in Cancer Patients. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33920140&form=6&db=m Combination of Niraparib, Cisplatin and Twist Knockdown in Cisplatin-Resistant Ovarian Cancer Cells Potentially Enhances Synthetic Lethality through ER-Stress Mediated Mitochondrial Apoptosis Pathway. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33921561&form=6&db=m Differences in PARP Inhibitors for the Treatment of Ovarian Cancer: Mechanisms of Action, Pharmacology, Safety, and Efficacy. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33926263&form=6&db=m Effect of PARP Inhibitors as Maintenance Treatment on Restricted Mean Survival Time in Platinum-Sensitive Recurrent Ovarian Cancer: A Systematic Review and Meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33952262&form=6&db=m Predictive value of RAD51 on the survival and drug responsiveness of ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33952453&form=6&db=m Synergistic Effect of Bazedoxifene and PARP Inhibitor in the Treatment of Ovarian Cancer Regardless of BRCA Mutation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33966038&form=6&db=m C/EBP? promotes poly(ADP-ribose) polymerase inhibitor resistance by enhancing homologous recombination repair in high-grade serous ovarian cancer. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33983578&form=6&db=m DNA Damage Repair Inhibitor for Breast Cancer Treatment. causal interaction,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33993885&form=6&db=m The efficacy and safety of niraparib for ovarian cancer: a single-center observational study from China. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33995588&form=6&db=m Prolonged response to treatment based on cell-free DNA analysis and molecular profiling in three patients with metastatic cancer: a case series. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34009012&form=6&db=m PARP1 Is Targeted by miR-519a-3p and Promotes the Migration, Invasion, and Tube Formation of Ovarian Cancer Cells. causal interaction,unassigned 4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34021367&form=6&db=m Poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors as maintenance therapy in women with newly diagnosed ovarian cancer: a systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34047476&form=6&db=m Identification of biomarkers complementary to homologous recombination deficiency for improving the clinical outcome of ovarian serous cystadenocarcinoma. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34053748&form=6&db=m The preferences of women with ovarian cancer for oral versus intravenous recurrence regimens. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34070674&form=6&db=m Breast Cancer Predisposition Genes and Synthetic Lethality. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34070839&form=6&db=m CCNE1 Is a Putative Therapeutic Target for ARID1A-Mutated Ovarian Clear Cell Carcinoma. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34071148&form=6&db=m BRCA Genetic Test and Risk-Reducing Salpingo-Oophorectomy for Hereditary Breast and Ovarian Cancer: State-of-the-Art. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34082614&form=6&db=m Advances in the treatment of platinum resistant epithelial ovarian cancer: an update on standard and experimental therapies. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34085794&form=6&db=m Major clinical research advances in gynecologic cancer in 2020. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34090705&form=6&db=m Rationale for combination PARP inhibitor and antiangiogenic treatment in advanced epithelial ovarian cancer: A review. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34090767&form=6&db=m Corrigendum to 'The forefront of ovarian cancer therapy: update on PARP inhibitors': [Annals of Oncology 31 (2020) 1148-1159]. unassigned - 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34108603&form=6&db=m PARP inhibitors promote stromal fibroblast activation by enhancing CCL5 autocrine signaling in ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34131002&form=6&db=m Phase 1 Combination Study of the CHK1 Inhibitor Prexasertib and the PARP Inhibitor Olaparib in High-grade Serous Ovarian Cancer and Other Solid Tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34133209&form=6&db=m Therapeutic Implications of Germline Testing in Patients With Advanced Cancers. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34195090&form=6&db=m The Role of PARP Inhibitors in the Ovarian Cancer Microenvironment: Moving Forward From Synthetic Lethality. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34284257&form=6&db=m The WRN helicase: resolving a new target in microsatellite unstable cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34293664&form=6&db=m Prognostic nomogram for progression-free survival in patients with BRCA mutations and platinum-sensitive recurrent ovarian cancer on maintenance olaparib therapy following response to chemotherapy. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34309133&form=6&db=m Rapid Progression of Metastatic Pancreatic Adenocarcinoma During Platinum-Based Therapy in a Patient Harboring a Pathogenic BRCA2 Germline Variant. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34316715&form=6&db=m Characterization of a RAD51C-silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34335884&form=6&db=m Combination treatment with cisplatin, paclitaxel and olaparib has synergistic and dose reduction potential in ovarian cancer cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34370190&form=6&db=m Research progress on the association between environmental pollutants and the resistance mechanism of PARP inhibitors in ovarian cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34371383&form=6&db=m Clinical benefit of systemic therapies for recurrent ovarian cancer-ESMO-MCBS scores. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34380641&form=6&db=m Comparative Assessment of Diagnostic Homologous Recombination Deficiency-Associated Mutational Signatures in Ovarian Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34391577&form=6&db=m PARP inhibitor maintenance for primary ovarian cancer - A missed opportunity for precision medicine. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34437203&form=6&db=m Success for First-Line PARP Inhibition in Ovarian Cancer. diagnostic usage,therapeutic application,unassigned 2,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34440232&form=6&db=m Cytocidal Antitumor Effects against Human Ovarian Cancer Cells Induced by B-Lactam Steroid Alkylators with Targeted Activity against Poly (ADP-Ribose) Polymerase (PARP) Enzymes in a Cell-Free Assay. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34445211&form=6&db=m PARP Inhibitors Display Differential Efficacy in Models of BRCA Mutant High-Grade Serous Ovarian Cancer. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34452747&form=6&db=m Germline mutations in Black patients with ovarian, fallopian tube and primary peritoneal carcinomas. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34463214&form=6&db=m Unveiling the mechanistic roles of chlorine substituted phthalazinone-based compounds containing chlorophenyl moiety towards the differential inhibition of poly (ADP-ribose) polymerase-1 in the treatment of lung cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34476650&form=6&db=m Hereditary pancreatic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34485111&form=6&db=m Efficacy and Safety of PARP Inhibitor Combination Therapy in Recurrent Ovarian Cancer: A Systematic Review and Meta-Analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34509297&form=6&db=m Adherence to PARP inhibitor therapy among women with ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34518297&form=6&db=m Synthetic Lethality in Ovarian Cancer. therapeutic application,unassigned 3,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34520432&form=6&db=m PARP inhibitors decrease response to subsequent platinum-based chemotherapy in patients with BRCA mutated ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34527850&form=6&db=m Ceralasertib-Mediated ATR Inhibition Combined With Olaparib in Advanced Cancers Harboring DNA Damage Response and Repair Alterations (Olaparib Combinations). causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34535173&form=6&db=m UBE2S promotes the progression and Olaparib resistance of ovarian cancer through Wnt/?-catenin signaling pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21774593&form=6&db=m Reduced mitogenicity of sera following weight loss in premenopausal women. ongoing research,unassigned 2,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12374694&form=6&db=m Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells. therapeutic application,unassigned 2,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15871945&form=6&db=m Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. ongoing research,unassigned 3,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17444865&form=6&db=m Combination therapy of poly (ADP-ribose) polymerase inhibitor 3-aminobenzamide and gemcitabine shows strong antitumor activity in pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640673&form=6&db=m Effect of the XIAP inhibitor Embelin on TRAIL-induced apoptosis of pancreatic cancer cells. ongoing research,unassigned 3,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18263593&form=6&db=m FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,4 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19384191&form=6&db=m Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells. causal interaction,diagnostic usage,unassigned 1,1,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19808866&form=6&db=m Oral Poly(ADP-Ribose) Polymerase-1 Inhibitor BSI-401 Has Antitumor Activity and Synergizes with Oxaliplatin against Pancreatic Cancer, Preventing Acute Neurotoxicity. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20931645&form=6&db=m C12orf48, termed PARP-1 binding protein, enhances poly(ADP-ribose) polymerase-1 (PARP-1) activity and protects pancreatic cancer cells from DNA damage. unassigned - 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21508395&form=6&db=m Evidence for the efficacy of Iniparib, a PARP-1 inhibitor, in BRCA2-associated pancreatic cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21833473&form=6&db=m BART inhibits pancreatic cancer cell invasion by inhibiting ARL2-mediated RhoA inactivation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21894434&form=6&db=m Ultra-violet irradiation induces apoptosis via mitochondrial pathway in pancreatic cancer cells. causal interaction,ongoing research,unassigned 2,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22134241&form=6&db=m Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22384823&form=6&db=m High nuclear poly-(ADP-ribose)-polymerase expression is prognostic of improved survival in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22404155&form=6&db=m Radiosensitization Effect of PARP Inhibition in Cells Exposed to Low and High LET Radiation. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23148997&form=6&db=m Optimize radiochemotherapy in pancreatic cancer: PARP inhibitors a new therapeutic opportunity. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23833311&form=6&db=m PARP-1 Regulates Resistance of Pancreatic Cancer to TRAIL Therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24189460&form=6&db=m Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24534203&form=6&db=m Combination of AZD2281 (Olaparib) and GX15-070 (Obatoclax) results in synergistic antitumor activities in preclinical models of pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24836647&form=6&db=m Radiosensitization of Pancreatic Cancer Cells In Vitro and In Vivo through Poly (ADP-ribose) Polymerase Inhibition with ABT-888. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24889936&form=6&db=m Parp-1 genetic ablation in Ela-myc mice unveils novel roles for Parp-1 in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25117293&form=6&db=m Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25271986&form=6&db=m Gemcitabine induces poly (ADP-ribose) polymerase-1 (PARP-1) degradation through autophagy in pancreatic cancer. causal interaction,unassigned 2,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25331547&form=6&db=m Overexpression of heat shock protein 27 (HSP27) increases gemcitabine sensitivity in pancreatic cancer cells through S-phase arrest and apoptosis. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25333575&form=6&db=m Knockdown of glucose-regulated protein 78 enhances poly(ADP-ribose) polymerase cleavage in human pancreatic cancer cells exposed to endoplasmic reticulum stress. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25621047&form=6&db=m JF-305, a pancreatic cancer cell line is highly sensitive to the PARP inhibitor olaparib. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25865228&form=6&db=m Autoimmune response to PARP and BRCA1/BRCA2 in cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26188110&form=6&db=m Combinative effects of ?-Lapachone and APO866 on pancreatic cancer cell death through reactive oxygen species production and PARP-1 activation. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26310895&form=6&db=m Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26687988&form=6&db=m Poly(ADP-Ribose) Polymerases: New Players in the Pathogenesis of Exocrine Pancreatic Diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26881472&form=6&db=m Genomic instability in pancreatic adenocarcinoma: a new step towards precision medicine and novel therapeutic approaches. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27466483&form=6&db=m Efficacy of the Combination of a PARP Inhibitor and UVC on Cancer Cells as Imaged by Focus Formation by the DNA Repair-related Protein 53BP1 Linked to Green Fluorescent Protein. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28033382&form=6&db=m Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28291774&form=6&db=m BRCA2 secondary mutation-mediated resistance to platinum and PARP inhibitor-based therapy in pancreatic cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28346693&form=6&db=m Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28404569&form=6&db=m Analysis Suggests Wider Use for PARP Inhibitors. causal interaction,unassigned 4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28412751&form=6&db=m Poly (ADP-ribose) polymerase inhibitor, an effective radiosensitizer in lung and pancreatic cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28699513&form=6&db=m PARP Inhibitor Drugs In The Treatment Of Breast, Ovarian, Prostate And Pancreatic Cancers: An Update of Clinical Trials. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28736628&form=6&db=m Predictive and prognostic biomarkers in personalized gastrointestinal cancer treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28819370&form=6&db=m Metformin Inhibits Gemcitabine Induced Apoptosis in Pancreatic Cancer Cell Lines. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29061803&form=6&db=m Enoxacin with UVA Irradiation Induces Apoptosis in the AsPC1 Human Pancreatic Cancer Cell Line Through ROS Generation. ongoing research,unassigned 3,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29293500&form=6&db=m PARP10 (ARTD10) modulates mitochondrial function. causal interaction,unassigned 1,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29434894&form=6&db=m Down-expression of poly(ADP-ribose) polymerase in p53-regulated pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30051098&form=6&db=m Rucaparib Monotherapy in Patients With Pancreatic Cancer and a Known Deleterious BRCA Mutation. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30407790&form=6&db=m Epidermal Growth Factor Receptor-Targeting Peptide Nanoparticles Simultaneously Deliver Gemcitabine and Olaparib To Treat Pancreatic Cancer with Breast Cancer 2 ( BRCA2) Mutation. therapeutic application,unassigned 4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30614530&form=6&db=m Cytoplasmic PARP-1 promotes pancreatic cancer tumorigenesis and resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30681819&form=6&db=m Current treatment landscape and emerging therapies for pancreatic cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30704928&form=6&db=m A PARP inhibitor in pancreatic cancer: Enhancement anti-tumour activity of chemoradiation therapy against pancreatic cancer? causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30940721&form=6&db=m Maintenance Rucaparib Controls Some Pancreatic Cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30968979&form=6&db=m PARP14 promotes the proliferation and gemcitabine chemoresistance of pancreatic cancer cells through activation of NF-?B pathway. causal interaction,unassigned 2,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31218365&form=6&db=m A decade of clinical development of PARP inhibitors in perspective. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31332344&form=6&db=m PARP inhibition - opportunities in pancreatic cancer. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31382681&form=6&db=m Paradigm Shifting of Systemic Chemotherapy for Unresectable Pancreatic Cancer in Japan. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31474062&form=6&db=m [The long coding RNA GSTM3TV2 acts an oncogene to promote chemoresistance in pancreatic cancer]. unassigned - 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31562758&form=6&db=m Health-related quality of life in patients with a germline BRCA mutation and metastatic pancreatic cancer receiving maintenance olaparib. therapeutic application,unassigned 2,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31787750&form=6&db=m Genotype-phenotype correlation in BRCA1/2 mutation-associated pancreatic cancer. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31835379&form=6&db=m Poly(ADP-Ribose) Polymerase Inhibitors in Pancreatic Cancer: A New Treatment Paradigms and Future Implications. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31856090&form=6&db=m ATM-Mutated Pancreatic Cancer: Clinical and Molecular Response to Gemcitabine/Nab-Paclitaxel After Genome-Based Therapy Resistance. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32030362&form=6&db=m PARP Inhibitors in Pancreatic Cancer: From Phase I to Plenary Session. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32062317&form=6&db=m Radioimmunotherapy of human pancreatic cancer xenografts in NOD-scid mice with [64Cu]Cu-NOTA-panitumumab F(ab')2 alone or combined with radiosensitizing gemcitabine and the PARP inhibitor, rucaparib. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32122376&form=6&db=m PARP inhibitors in pancreatic cancer: molecular mechanisms and clinical applications. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32164505&form=6&db=m A Review on Poly (ADP-ribose) Polymerase (PARP) Inhibitors and Synthetic Methodologies. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32181758&form=6&db=m [Medical treatment options in BRCA-associated cancers]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32193285&form=6&db=m Inactivation of the prolyl isomerase Pin1 sensitizes BRCA1-proficient breast cancer to PARP inhibition. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32194909&form=6&db=m Acquired multiple secondary BRCA2 mutations upon PARPi resistance in a metastatic pancreatic cancer patient harboring a BRCA2 germline mutation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32276472&form=6&db=m Targeted PARP Inhibition Combined with FGFR1 Blockade is Synthetically Lethal to Malignant Cells in Patients with Pancreatic Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32444694&form=6&db=m Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32695234&form=6&db=m Maintenance therapies in metastatic pancreatic cancer: present and future with a focus on PARP inhibitors. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32873698&form=6&db=m Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32936674&form=6&db=m PARP inhibition in treatment of pancreatic cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33152708&form=6&db=m Cost-Effectiveness of Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33198203&form=6&db=m BRCA in Gastrointestinal Cancers: Current Treatments and Future Perspectives. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33214574&form=6&db=m DNA damage induced by KP372-1 hyperactivates PARP1 and enhances lethality of pancreatic cancer cells with PARP inhibition. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33268569&form=6&db=m Combinatorial Efficacy of Olaparib with Radiation and ATR Inhibitor Requires PARP1 Protein in Homologous Recombination-Proficient Pancreatic Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33277249&form=6&db=m Growth of pancreatic cancers with hemizygous chromosomal 17p loss of MYBBP1A can be preferentially targeted by PARP inhibitors. causal interaction,unassigned 3,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33295810&form=6&db=m The promise and current status of CDK12/13 inhibition for the treatment of cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33341987&form=6&db=m Poly(ADP-ribose) polymerase inhibition in pancreatic cancer. causal interaction,unassigned 3,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33376937&form=6&db=m Update on the Role of Poly (ADP-Ribose) Polymerase Inhibitors in the DNA Repair-Deficient Pancreatic Cancers: A Narrative Review. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33391424&form=6&db=m Tephrosin induces apoptosis of human pancreatic cancer cells through the generation of reactive oxygen species. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33399070&form=6&db=m Germinal BRCA1-2 pathogenic variants (gBRCA1-2pv) and pancreatic cancer: epidemiology of an Italian patient cohort. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33407459&form=6&db=m A novel somatic BRCA2 point mutation in a metastatic pancreatic cancer patient: a case report. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33520371&form=6&db=m Nuclear translocation of the receptor tyrosine kinase c-MET reduces the treatment efficacies of olaparib and gemcitabine in pancreatic ductal adenocarcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33552258&form=6&db=m MicroRNA-7 modulates cellular senescence to relieve gemcitabine resistance by targeting PARP1/NF-?B signaling in pancreatic cancer cells. causal interaction,unassigned 1,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33573176&form=6&db=m Radiosensitizing Pancreatic Cancer with PARP Inhibitor and Gemcitabine: An In Vivo and a Whole-Transcriptome Analysis after Proton or Photon Irradiation. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33662100&form=6&db=m Olaparib Monotherapy for Previously Treated Pancreatic Cancer With DNA Damage Repair Genetic Alterations Other Than Germline BRCA Variants: Findings From 2 Phase 2 Nonrandomized Clinical Trials. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33805293&form=6&db=m The Significance of Targeting Poly (ADP-Ribose) Polymerase-1 in Pancreatic Cancer for Providing a New Therapeutic Paradigm. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33888155&form=6&db=m Complete pathological response to olaparib and bevacizumab in advanced cervical cancer following chemoradiation in a BRCA1 mutation carrier: a case report. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33891252&form=6&db=m PARP inhibitors: shifting the paradigm in the treatment of pancreatic cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33970687&form=6&db=m Phase II Study of Maintenance Rucaparib in Patients With Platinum-Sensitive Advanced Pancreatic Cancer and a Pathogenic Germline or Somatic Variant in BRCA1, BRCA2, or PALB2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,4 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34025781&form=6&db=m The role of PARP inhibitors in BRCA mutated pancreatic cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34083224&form=6&db=m More PARP Inhibitors in Pancreatic Cancer? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34201963&form=6&db=m Gemcitabine-Based Chemoradiotherapy Enhanced by a PARP Inhibitor in Pancreatic Cancer Cell Lines. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34280886&form=6&db=m MTA2 sensitizes gastric cancer cells to PARP inhibition by induction of DNA replication stress. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34285063&form=6&db=m Opportunities for Utilization of DNA Repair Inhibitors in Homologous Recombination Repair-Deficient and Proficient Pancreatic Adenocarcinoma. causal interaction,unassigned 3,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34439854&form=6&db=m BRCAness as a Biomarker of Susceptibility to PARP Inhibitors in Glioblastoma Multiforme. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34476650&form=6&db=m Hereditary pancreatic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12161103&form=6&db=m Absence of endogenous interleukin-6 enhances the inflammatory response during acute pancreatitis induced by cerulein in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,1 2.4.2.30 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15184362&form=6&db=m Stabilization of exocytosis by dynamic F-actin coating of zymogen granules in pancreatic acini. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16127429&form=6&db=m Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16979620&form=6&db=m Effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase, in a mouse model of acute pancreatitis induced by cerulein. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17533414&form=6&db=m Therapeutic treatment with poly(ADP-ribose) polymerase inhibitors attenuates the severity of acute pancreatitis and associated liver and lung injury. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19330731&form=6&db=m Does the 3-aminobenzamide effect on bacterial translocation affect experimental acute necrotizing pancreatitis? ongoing research,unassigned 4,0 2.4.2.30 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22750969&form=6&db=m Inhibition of Poly(ADP-Ribose) Polymerase Attenuates Acute Kidney Injury in Sodium Taurocholate-Induced Acute Pancreatitis in Rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23954400&form=6&db=m Parp1 deficient mice are protected from streptozotocin-induced diabetes but not caerulein-induced pancreatitis, independent of the induction of Reg family genes. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26687988&form=6&db=m Poly(ADP-Ribose) Polymerases: New Players in the Pathogenesis of Exocrine Pancreatic Diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27465581&form=6&db=m Poly(ADP-ribose) polymerase inhibition suppresses inflammation and promotes recovery from adrenal injury in a rat model of acute necrotizing pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31274831&form=6&db=m Effects of The Poly(ADP-ribose) Polymerase Inhibitor Olaparib in Cerulein-Induced Pancreatitis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33808340&form=6&db=m Poly(ADP-Ribose) Polymerase 1 Promotes Inflammation and Fibrosis in a Mouse Model of Chronic Pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Pancreatitis, Acute Necrotizing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27465581&form=6&db=m Poly(ADP-ribose) polymerase inhibition suppresses inflammation and promotes recovery from adrenal injury in a rat model of acute necrotizing pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Pancreatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33808340&form=6&db=m Poly(ADP-Ribose) Polymerase 1 Promotes Inflammation and Fibrosis in a Mouse Model of Chronic Pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Panniculitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31002019&form=6&db=m Pancreatic acinar cell carcinoma is associated with BRCA2 germline mutations: a case report and literature review. ongoing research,unassigned 1,0 2.4.2.30 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15582275&form=6&db=m Poly(ADP-ribosyl)ation and aging. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 2.4.2.30 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16338061&form=6&db=m Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27833142&form=6&db=m Murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28800469&form=6&db=m Immunotherapy in ovarian, endometrial and cervical cancer: State of the art and future perspectives. therapeutic application,unassigned 3,0 2.4.2.30 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29749388&form=6&db=m Retraction: Murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Papillomavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22454210&form=6&db=m Expression of BAG-1 and PARP-1 in Precursor Lesions and Invasive Cervical Cancer Associated with Human Papillomavirus (HPV). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.4.2.30 Paraganglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26564962&form=6&db=m Myelin oligodendrocyte glycoprotein (MOG35-55)-induced experimental autoimmune encephalomyelitis is ameliorated in interleukin-32 alpha transgenic mice. ongoing research,unassigned 2,0 2.4.2.30 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26985768&form=6&db=m CCR5 knockout suppresses experimental autoimmune encephalomyelitis in C57BL/6 mice. unassigned - 2.4.2.30 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31830622&form=6&db=m HIV-1 Tat protein attenuates the clinical course of experimental autoimmune encephalomyelitis (EAE). ongoing research,unassigned 3,0 2.4.2.30 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32007705&form=6&db=m Maraviroc attenuates the pathogenesis of experimental autoimmune encephalitis. ongoing research,unassigned 3,0 2.4.2.30 Paraproteinemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20644899&form=6&db=m Altered mRNA expression of telomere-associated genes in monoclonal gammopathy of undetermined significance and multiple myeloma. ongoing research,unassigned 3,0 2.4.2.30 Paraproteinemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29632340&form=6&db=m Targeting the MALAT1/PARP1/LIG3 complex induces DNA damage and apoptosis in multiple myeloma. diagnostic usage,unassigned 3,0 2.4.2.30 Paraproteinemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32079692&form=6&db=m Exploiting MYC-induced PARPness to target genomic instability in multiple myeloma. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Parasitic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18396434&form=6&db=m Transient inhibition of poly(ADP-ribose) polymerase expression and activity by Toxoplasma gondii is dispensable for parasite-mediated blockade of host cell apoptosis and intracellular parasite replication. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Paratuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16462859&form=6&db=m Induction of humoral immunity in response to immunization with recombinant Mycobacterium bovis BCG expressing the S1 subunit of Bordetella pertussis toxin. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10318960&form=6&db=m Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10668429&form=6&db=m Implication of poly (ADP-ribose) polymerase (PARP) in neurodegeneration and brain energy metabolism. Decreases in mouse brain NAD+ and ATP caused by MPTP are prevented by the PARP inhibitor benzamide. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11376691&form=6&db=m Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11501263&form=6&db=m [Neuronal death: potential role of the nuclear enzyme, poly (ADP-ribose) polymerase] causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12880486&form=6&db=m Peroxynitrite and mitochondrial dysfunction in the pathogenesis of Parkinson's disease. therapeutic application,unassigned 1,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14985416&form=6&db=m Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-[3-[4-(4-chlorophenyl)-1-piperazinyl] propyl]-4(3H)-quinazolinone (FR255595), in an in vitro model of cell death and in mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15113847&form=6&db=m A new poly(ADP-ribose) polymerase inhibitor, FR261529 [2-(4-chlorophenyl)-5-quinoxalinecarboxamide], ameliorates methamphetamine-induced dopaminergic neurotoxicity in mice. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15257133&form=6&db=m The expression of PARP, NF-kappa B and parvalbumin is increased in Parkinson disease. causal interaction,unassigned 3,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911329&form=6&db=m Mediation of cell death by poly(ADP-ribose) polymerase-1. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026317&form=6&db=m Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies. causal interaction,unassigned 3,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17362997&form=6&db=m Poly (ADP-ribose) polymerase-1 (PARP-1) genetic variants are protective against Parkinson's disease. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17449015&form=6&db=m Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21644054&form=6&db=m PARP1 and CASP3 gene expression in a patient with multiple head and neck squamous cell carcinoma and Parkinson disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21767974&form=6&db=m Association analysis of PARP1 polymorphisms with Parkinson's disease. causal interaction,diagnostic usage,unassigned 4,4,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23974709&form=6&db=m Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24254220&form=6&db=m Effects of Poly (ADP-ribose) Polymerase Inhibitor 3-Aminobenzamide on Blood-Brain Barrier and Dopaminergic Neurons of Rats with Lipopolysaccharide-Induced Parkinson's Disease. ongoing research,unassigned 2,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24874851&form=6&db=m Poly (ADP-ribose) in the pathogenesis of Parkinson's disease. ongoing research,unassigned 1,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25881554&form=6&db=m PARP-1 involvement in neurodegeneration: A focus on Alzheimer's and Parkinson's diseases. ongoing research,unassigned 2,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27000229&form=6&db=m Poly (ADP-ribose) polymerase-1 (PARP-1) -410C/T polymorphism in Sicilian patients with Parkinson's disease. causal interaction,unassigned 2,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27031963&form=6&db=m Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson's disease. causal interaction,unassigned 3,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27662363&form=6&db=m FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29062606&form=6&db=m The neuroprotective effect of nicotine in Parkinson's disease models is associated with inhibiting PARP-1 and caspase-3 cleavage. unassigned - 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30460108&form=6&db=m Increase in anti-apoptotic molecules, nucleolin, and heat shock protein 70, against upregulated LRRK2 kinase activity. causal interaction,unassigned 4,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30699325&form=6&db=m PARP Inhibitors and Parkinson's Disease. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30776897&form=6&db=m A PARP-1 Feed-Forward Mechanism To Accelerate ?-Synuclein Toxicity in Parkinson's Disease. unassigned - 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30974833&form=6&db=m Rhododendrin-Induced RNF146 Expression via Estrogen Receptor ? Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress. therapeutic application,unassigned 1,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32475059&form=6&db=m Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes ?-synuclein degradation via transcription factor EB-dependent autophagy in mutant ?-synucleinA53T model of Parkinson's disease. unassigned - 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33387580&form=6&db=m Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33516746&form=6&db=m Poly (ADP-ribose) polymerase 1 and Parkinson's disease: A study in post-mortem human brain. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,1 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33681613&form=6&db=m Computational Analysis Indicates That PARP1 Acts as a Histone Deacetylases Interactor Sharing Common Lysine Residues for Acetylation, Ubiquitination, and SUMOylation in Alzheimer's and Parkinson's Disease. therapeutic application,unassigned 1,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33788167&form=6&db=m Evaluation of a Low-Toxicity PARP Inhibitor as a Neuroprotective Agent for Parkinson's Disease. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34230558&form=6&db=m Untangling the genetic link between type 1 and type 2 diabetes using functional genomics. causal interaction,unassigned 3,0 2.4.2.30 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9027539&form=6&db=m Whooping cough and Parkinson's disease. The Europarkinson Preparatory Activity Research Group. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10318960&form=6&db=m Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11050121&form=6&db=m NMDA but not non-NMDA excitotoxicity is mediated by Poly(ADP-ribose) polymerase. causal interaction,unassigned 4,0 2.4.2.30 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11160908&form=6&db=m Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12853316&form=6&db=m Poly(ADP-Ribose) polymerase-1 in acute neuronal death and inflammation: a strategy for neuroprotection. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529360&form=6&db=m Poly(ADP-ribosyl)ation enzyme-1 as a target for neuroprotection in acute central nervous system injury. therapeutic application,unassigned 3,0 2.4.2.30 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17309584&form=6&db=m 5-Aminoisoquinolin-1(2H)-one, a water-soluble poly (ADP-ribose) polymerase (PARP) inhibitor reduces the evolution of experimental periodontitis in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28570002&form=6&db=m Role of poly(ADP-ribose) polymerase activation in the pathogenesis of periodontitis in diabetes. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14630900&form=6&db=m Role of the activation of the nuclear enzyme poly(ADP-ribose) polymerase in the pathogenesis of periodontitis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17309584&form=6&db=m 5-Aminoisoquinolin-1(2H)-one, a water-soluble poly (ADP-ribose) polymerase (PARP) inhibitor reduces the evolution of experimental periodontitis in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28570002&form=6&db=m Role of poly(ADP-ribose) polymerase activation in the pathogenesis of periodontitis in diabetes. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32512258&form=6&db=m Hematogenous apoptotic mechanism in salivary glands in chronic periodontitis. ongoing research,unassigned 3,0 2.4.2.30 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15298348&form=6&db=m Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17021258&form=6&db=m Nicotinamide reverses neurological and neurovascular deficits in streptozotocin diabetic rats. causal interaction,unassigned 1,0 2.4.2.30 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19900402&form=6&db=m Concurrent targeting of nitrosative stress-PARP pathway corrects functional, behavioral and biochemical deficits in experimental diabetic neuropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4 2.4.2.30 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21300148&form=6&db=m PARP inhibition alleviates diabetes-induced systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation: Correlation with peripheral nerve function. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21617845&form=6&db=m Poly(ADP-ribose)polymerase inhibition counteracts renal hypertrophy and multiple manifestations of peripheral neuropathy in diabetic Akita mice. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26921631&form=6&db=m PARP inhibition attenuates neuroinflammation and oxidative stress in chronic constriction injury induced peripheral neuropathy. causal interaction,unassigned 4,0 2.4.2.30 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27084773&form=6&db=m Morin Mitigates Chronic Constriction Injury (CCI)-Induced Peripheral Neuropathy by Inhibiting Oxidative Stress Induced PARP Over-Activation and Neuroinflammation. causal interaction,unassigned 4,0 2.4.2.30 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29983087&form=6&db=m Can Poly (ADP-Ribose) Polymerase Inhibitors Palliate Paclitaxel-Induced Peripheral Neuropathy in Patients With Cancer? therapeutic application,unassigned 4,0 2.4.2.30 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30839241&form=6&db=m Poly (ADP-Ribose) Polymerase Inhibition for Chemotherapy-Induced Peripheral Neuropathy: A Meta-Analysis of Placebo-Controlled Trials. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Peritoneal Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22159350&form=6&db=m Poly(ADP-ribose) polymerase-1 in high glucose-induced epithelial-mesenchymal transition during peritoneal fibrosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Peritoneal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25355929&form=6&db=m A Phase I study of veliparib (ABT-888) in combination with low-dose fractionated whole abdominal radiation therapy in patients with advanced solid malignancies and peritoneal carcinomatosis. therapeutic application,unassigned 2,0 2.4.2.30 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17543554&form=6&db=m Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27131737&form=6&db=m Moesin regulates neutrophil rolling velocity in vivo. ongoing research,unassigned 3,0 2.4.2.30 Persistent Hyperplastic Primary Vitreous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31462148&form=6&db=m Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease. ongoing research,unassigned 2,0 2.4.2.30 Persistent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8656619&form=6&db=m Production of extracellular virulence factors by Pseudomonas aeruginosa isolates obtained from tracheal, urinary tract, and wound infections. causal interaction,unassigned 3,0 2.4.2.30 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1978729&form=6&db=m Neuromodulatory effects of atrial natriuretic factor are independent of guanylate cyclase in adrenergic neuronal pheochromocytoma cells. causal interaction,unassigned 1,0 2.4.2.30 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7746465&form=6&db=m Accentuation by pertussis toxin of the 5-hydroxytryptamine-induced potentiation of ATP-evoked responses in rat pheochromocytoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15036348&form=6&db=m Ergothioneine rescues PC12 cells from beta-amyloid-induced apoptotic death. diagnostic usage,unassigned 1,0 2.4.2.30 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16093393&form=6&db=m PolyADP-ribosylation is involved in neurotrophic activity. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16140209&form=6&db=m Nitric oxide induces apoptosis via AP-1-driven upregulation of COX-2 in rat pheochromocytoma cells. causal interaction,ongoing research,unassigned 2,4,0 2.4.2.30 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18093742&form=6&db=m Pertussis toxin B-oligomer suppresses human immunodeficiency virus-1 Tat-induced neuronal apoptosis through feedback inhibition of phospholipase C-beta by protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 2.4.2.30 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18407464&form=6&db=m Betagamma subunits of G(i/o) suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23675320&form=6&db=m Supraphysiological doses of performance enhancing anabolic-androgenic steroids exert direct toxic effects on neuron-like cells. ongoing research,unassigned 3,0 2.4.2.30 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26112249&form=6&db=m Tetrachlorobenzoquinone triggers the cleavage of Bid and promotes the cross-talk of extrinsic and intrinsic apoptotic signalings in pheochromocytoma (PC) 12 cells. ongoing research,unassigned 1,0 2.4.2.30 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28694771&form=6&db=m Nupr1 Modulates Methamphetamine-Induced Dopaminergic Neuronal Apoptosis and Autophagy through CHOP-Trib3-Mediated Endoplasmic Reticulum Stress Signaling Pathway. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28698968&form=6&db=m Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity. ongoing research,unassigned 4,0 2.4.2.30 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Photosensitivity Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11161713&form=6&db=m Photodynamic therapy-induced death of MCF-7 human breast cancer cells: a role for caspase-3 in the late steps of apoptosis but not for the critical lethal event. therapeutic application,unassigned 1,0 2.4.2.30 Photosensitivity Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11368515&form=6&db=m Caspase-resistant vimentin suppresses apoptosis after photodynamic treatment with a silicon phthalocyanine in Jurkat cells. therapeutic application,unassigned 2,0 2.4.2.30 Photosensitivity Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11494135&form=6&db=m Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-a methylester photosensitization. unassigned - 2.4.2.30 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2440314&form=6&db=m Pertussis toxin inhibits somatostatin-induced K+ conductance in human pituitary tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,4 2.4.2.30 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2856941&form=6&db=m Pertussis toxin treatment blocks the inhibition of somatostatin and increases the stimulation by forskolin of cyclic AMP accumulation and adrenocorticotropin secretion from mouse anterior pituitary tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2900331&form=6&db=m Pertussis toxin modifies the characteristics of both the inhibitory GTP binding proteins and the somatostatin receptor in anterior pituitary tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3038612&form=6&db=m Pertussis toxin distinguishes between muscarinic receptor-mediated inhibition of adenylate cyclase and stimulation of phosphoinositide hydrolysis in Flow 9000 cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6138037&form=6&db=m Pertussis toxin blocks somatostatin's inhibition of stimulated cyclic AMP accumulation in anterior pituitary tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,3 2.4.2.30 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8861541&form=6&db=m Phospholipase C activation in rat pituitary adenoma (GH) cells. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15564335&form=6&db=m The role of poly (adenosine 5'-diphosphate-ribose) polymerase in the response of pituitary tumor cells to reactive oxygen species. causal interaction,ongoing research,unassigned 2,4,0 2.4.2.30 Placenta, Retained http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12950691&form=6&db=m Poly(ADP-ribose) polymerase in bovine retained and not retained placenta. unassigned - 2.4.2.30 Plasmacytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3936499&form=6&db=m Characterization of the poly(ADP-ribose) polymerase associated with free cytoplasmic mRNA-protein particles. causal interaction,unassigned 4,0 2.4.2.30 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12083777&form=6&db=m Identification of autoantibodies associated with systemic lupus erythematosus. diagnostic usage,unassigned 3,0 2.4.2.30 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14996947&form=6&db=m Critical role of L-selectin and histamine H4 receptor in zymosan-induced neutrophil recruitment from the bone marrow: comparison with carrageenan. unassigned - 2.4.2.30 Pneumococcal Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25432510&form=6&db=m Vaccines, emerging viruses, and how to avoid disaster. therapeutic application,unassigned 2,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3018037&form=6&db=m Phenotypic comparison of Pseudomonas aeruginosa strains isolated from a variety of clinical sites. diagnostic usage,ongoing research,unassigned 4,1,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8282618&form=6&db=m Alveolar epithelial injury and pleural empyema in acute P. aeruginosa pneumonia in anesthetized rabbits. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9632568&form=6&db=m Pseudomonas aeruginosa exoenzyme S is a mitogen but not a superantigen for human T lymphocytes. causal interaction,unassigned 4,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10899895&form=6&db=m Pseudomonas aeruginosa exoenzyme S induces transcriptional expression of proinflammatory cytokines and chemokines. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11818323&form=6&db=m Activation of poly(ADP-Ribose) polymerase-1 is a central mechanism of lipopolysaccharide-induced acute lung inflammation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12594058&form=6&db=m Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14752285&form=6&db=m Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15728518&form=6&db=m Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17056581&form=6&db=m Poly(ADP-ribose) polymerase-1 inhibition prevents eosinophil recruitment by modulating Th2 cytokines in a murine model of allergic airway inflammation: a potential specific effect on IL-5. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18261157&form=6&db=m Post-allergen challenge inhibition of poly(ADP-ribose) polymerase harbors therapeutic potential for treatment of allergic airway inflammation. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21420246&form=6&db=m Functional Polymorphisms of Base Excision Repair Genes XRCC1 and APEX1 Predict Risk of Radiation Pneumonitis in Patients with Non-Small Cell Lung Cancer Treated with Definitive Radiation Therapy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22841009&form=6&db=m Poly (ADP-ribose) polymerase 14 and its enzyme activity regulates T(H)2 differentiation and allergic airway disease. therapeutic application,unassigned 4,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24229378&form=6&db=m Inhibition of poly (adenosine diphosphate-ribose) polymerase attenuates lung-kidney crosstalk induced by intratracheal lipopolysaccharide instillation in rats. ongoing research,unassigned 4,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24444146&form=6&db=m Poly(ADP-ribose) polymerase inhibition with HYDAMTIQ reduces allergen-induced asthma-like reaction, bronchial hyper-reactivity and airway remodelling. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25304310&form=6&db=m The role of poly(ADP-ribose) polymerase-1 inhibitor in carrageenan-induced lung inflammation in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25404465&form=6&db=m PARP inhibitor, olaparib ameliorates acute lung and kidney injury upon intratracheal administration of LPS in mice. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26090668&form=6&db=m The Role of ExoS in Dissemination of Pseudomonas aeruginosa during Pneumonia. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26600069&form=6&db=m TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation. causal interaction,unassigned 3,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28974953&form=6&db=m Poly(ADP-Ribose)Polymerase-1 in Lung Inflammatory Disorders: A Review. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29355504&form=6&db=m PARP-1 inhibition ameliorates elastase induced lung inflammation and emphysema in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29483769&form=6&db=m Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32513195&form=6&db=m Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction. unassigned - 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32865668&form=6&db=m Pharmacological inhibition of poly (ADP-ribose) polymerase by olaparib ameliorates influenza-virus-induced pneumonia in mice. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34023129&form=6&db=m Risk of pneumonitis in cancer patients treated with PARP inhibitors: A meta-analysis of randomized controlled trials and a pharmacovigilance study of the FAERS database. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34085162&form=6&db=m Ubiquitin-Specific Protease 14 (USP14) Aggravates Inflammatory Response and Apoptosis of Lung Epithelial Cells in Pneumonia by Modulating Poly (ADP-Ribose) Polymerase-1 (PARP-1). causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Poliomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9713945&form=6&db=m Repeated administration of whole-cell and acellular pertussis vaccines affects haemodynamics and autonomic responsiveness. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Poliomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11483264&form=6&db=m Immunogenicity and reactogenicity of diphtheria, tetanus and pertussis toxoids combined with inactivated polio vaccine, when administered concomitantly with or as a diluent for a Hib conjugate vaccine. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Poliomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18782261&form=6&db=m Effect of HLA genotype or CTLA-4 polymorphism on cytokine response in healthy children. ongoing research,unassigned 4,0 2.4.2.30 Poliomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20864810&form=6&db=m Humoral immunity of dTap-IPV vaccine (REPEVAX(®)) administered one month after dT-IPV vaccine (REVAXIS(®)) in adults with unknown vaccination history. therapeutic application,unassigned 2,0 2.4.2.30 Poliomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27753797&form=6&db=m A Randomized, Controlled Study of DTaP-IPV-HB-PRP-T, a Fully Liquid Hexavalent Vaccine, Administered in a 3-, 5- and 11- to 12-month Schedule. diagnostic usage,unassigned 3,0 2.4.2.30 Poliomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30208475&form=6&db=m Immunogenicity and Safety of Monovalent Acellular Pertussis Vaccine at Birth: A Randomized Clinical Trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,2 2.4.2.30 Porcine Reproductive and Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25614100&form=6&db=m Resolution of the cellular proteome of the nucleocapsid protein from a highly pathogenic isolate of porcine reproductive and respiratory syndrome virus identifies PARP-1 as a cellular target whose interaction is critical for virus biology. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15596529&form=6&db=m Excessive stimulation of poly(ADP-ribosyl)ation contributes to endothelial dysfunction in pre-eclampsia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15778700&form=6&db=m Excessive stimulation of poly(ADP-ribosyl)ation contributes to endothelial dysfunction in pre-eclampsia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22339234&form=6&db=m Contribution of poly(ADP-ribose) polymerase to endothelial dysfunction and hypertension in a rat model of pre-eclampsia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33784242&form=6&db=m CLDN1 regulates trophoblast apoptosis and proliferation in preeclampsia. causal interaction,unassigned 3,0 2.4.2.30 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9013854&form=6&db=m The interleukin 1beta-converting enzyme inhibitor CrmA prevents Apo1/Fas- but not glucocorticoid-induced poly(ADP-ribose) polymerase cleavage and apoptosis in lymphoblastic leukemia cells. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15596292&form=6&db=m DNA repair gene XRCC1 polymorphisms in childhood acute lymphoblastic leukemia. causal interaction,unassigned 1,0 2.4.2.30 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899912&form=6&db=m Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18292930&form=6&db=m Modulation of ceramide metabolism in T-leukemia cell lines potentiates apoptosis induced by the cationic antimicrobial peptide bovine lactoferricin. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19478700&form=6&db=m Good early treatment response in childhood acute lymphoblastic leukemia is associated with Bax nuclear accumulation and PARP cleavage. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23753023&form=6&db=m Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24039967&form=6&db=m Searching in mother nature for anti-cancer activity: anti-proliferative and pro-apoptotic effect elicited by green barley on leukemia/lymphoma cells. therapeutic application,unassigned 2,0 2.4.2.30 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26619102&form=6&db=m PARP-1 expression in CD34+ leukemic cells in childhood acute lymphoblastic leukemia: relation to response to initial therapy and other prognostic factors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27644631&form=6&db=m Curcumin Induces Apoptosis in Pre-B Acute Lymphoblastic Leukemia Cell Lines Via PARP-1 Cleavage. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31447348&form=6&db=m LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32409690&form=6&db=m TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition. therapeutic application,unassigned 1,0 2.4.2.30 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11222085&form=6&db=m Mechanisms of JP-8 jet fuel toxicity. I. Induction of apoptosis in rat lung epithelial cells. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15240138&form=6&db=m Inhibition of phosphatidylinositol 3'-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31447348&form=6&db=m LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32149078&form=6&db=m Autophagy Inhibition Potentiates the Anticancer Effects of a Bendamustine Derivative NL-101 in Acute T Lymphocytic Leukemia. unassigned - 2.4.2.30 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32409690&form=6&db=m TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition. therapeutic application,unassigned 1,0 2.4.2.30 Primary Ovarian Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26827941&form=6&db=m Resveratrol inhibits inflammatory signaling implicated in ionizing radiation-induced premature ovarian failure through antagonistic crosstalk between silencing information regulator 1 (SIRT1) and poly(ADP-ribose) polymerase 1 (PARP-1). unassigned - 2.4.2.30 Primary Ovarian Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33465522&form=6&db=m Promising anti- cervical carcinoma and inflammatory agent, Resveratrol targets poly (ADP-ribose) polymerase 1 (PARP-1) induced premature ovarian failure with a potent enzymatic modulatory activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,2 2.4.2.30 Progeria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24843141&form=6&db=m Mechanisms controlling the smooth muscle cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Progeria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26359359&form=6&db=m All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24436031&form=6&db=m Expression of PARP-1 and its active polymer PAR in prostate cancer and benign prostatic hyperplasia in Chinese patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10381629&form=6&db=m Synthesis of procaspases-3 and -7 during apoptosis in prostate cancer cells. therapeutic application,unassigned 1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11061948&form=6&db=m Essential role for G proteins in prostate cancer cell growth and signaling. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12460902&form=6&db=m Gene therapy for prostate cancer by targeting poly(ADP-ribose) polymerase. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14523021&form=6&db=m Fibronectin protects prostate cancer cells from tumor necrosis factor-alpha-induced apoptosis via the AKT/survivin pathway. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15011755&form=6&db=m Inhibition of proteasome activity by various fruits and vegetables is associated with cancer cell death. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252149&form=6&db=m Selenite-induced p53 Ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells. causal interaction,unassigned 1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313917&form=6&db=m Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389. therapeutic application,unassigned 2,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15342424&form=6&db=m The ADPRT V762A genetic variant contributes to prostate cancer susceptibility and deficient enzyme function. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492266&form=6&db=m HIV-1 protease inhibitor, ritonavir: a potent inhibitor of CYP3A4, enhanced the anticancer effects of docetaxel in androgen-independent prostate cancer cells in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,3 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15752900&form=6&db=m Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15868402&form=6&db=m Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16490787&form=6&db=m In prostate cancer cells the interaction of C/EBPalpha with Ku70, Ku80, and poly(ADP-ribose) polymerase-1 increases sensitivity to DNA damage. causal interaction,unassigned 4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17214747&form=6&db=m Evidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17295209&form=6&db=m Radiation-induced PARP activation is enhanced through EGFR-ERK signaling. ongoing research,unassigned 3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17332294&form=6&db=m Standard treatments induce antigen-specific immune responses in prostate cancer. unassigned - 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18377872&form=6&db=m Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20383708&form=6&db=m A novel bis-indole destabilizes microtubules and displays potent in vitro and in vivo antitumor activity in prostate cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20409643&form=6&db=m Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20495366&form=6&db=m Genetic polymorphisms in XRCC1 associated with radiation therapy in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20564423&form=6&db=m Phenoxodiol inhibits growth of metastatic prostate cancer cells. causal interaction,unassigned 3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20658310&form=6&db=m Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20663036&form=6&db=m Antineoplastic effect of beta-elemene on prostate cancer cells and other types of solid tumour cells. causal interaction,unassigned 1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20940411&form=6&db=m Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21045146&form=6&db=m Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21204621&form=6&db=m KNK437, a benzylidene lactam compound, sensitises prostate cancer cells to the apoptotic effect of hyperthermia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21385925&form=6&db=m Transcription-induced DNA double strand breaks: both an oncogenic force and potential therapeutic target? causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21571912&form=6&db=m Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21575858&form=6&db=m Beyond hormone therapy for prostate cancer with PARP inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21575865&form=6&db=m Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21911444&form=6&db=m Bitter melon extract impairs prostate cancer cell-cycle progression and delays prostatic intraepithelial neoplasia in TRAMP model. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22001597&form=6&db=m ICAM-1 and AMPK regulate cell detachment and apoptosis by N-methyl-N'-nitro-N-nitrosoguanidine, a widely spread environmental chemical, in human hormone-refractory prostate cancers. unassigned - 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22179663&form=6&db=m Does PTEN Loss Impair DNA Double-Strand Break Repair by Homologous Recombination? therapeutic application,unassigned 2,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22179721&form=6&db=m Methylseleninic acid potentiates multiple types of cancer cells to ABT-737-induced apoptosis by targeting Mcl-1 and Bad. ongoing research,unassigned 4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22453599&form=6&db=m Carnosic acid modulates Akt/IKK/NF-?B signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells. causal interaction,unassigned 1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22571975&form=6&db=m ?-Santalol, a derivative of sandalwood oil, induces apoptosis in human prostate cancer cells by causing caspase-3 activation. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22753732&form=6&db=m Anticancer effects of eleven triterpenoids derived from Antrodia camphorata. unassigned - 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22993403&form=6&db=m Dual roles of PARP-1 promote cancer growth and progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23524863&form=6&db=m Poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of advanced germline BRCA2 mutant prostate cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23565244&form=6&db=m PARP inhibition sensitizes to low dose-rate radiation TMPRSS2-ERG fusion gene-expressing and PTEN-deficient prostate cancer cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23807292&form=6&db=m Poly (ADP-ribose) polymerase 1 protein expression in normal and neoplastic prostatic tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23824300&form=6&db=m Piperine, a Bioactive Component of Pepper Spice Exerts Therapeutic Effects on Androgen Dependent and Androgen Independent Prostate Cancer Cells. therapeutic application,unassigned 3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23847380&form=6&db=m Olaparib shows promise in multiple tumor types. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23906044&form=6&db=m N-substituted piperazinopyridylsteroid derivatives as abiraterone analogues inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines. unassigned - 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24052043&form=6&db=m The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivo activity against prostate cancer and circumvents MDR1 resistance. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24100507&form=6&db=m MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cells. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24204199&form=6&db=m Targeted radiosensitization of ETS fusion-positive prostate cancer through PARP1 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24239883&form=6&db=m Inhibition of PARP1 by small interfering RNA enhances docetaxel activity against human prostate cancer PC3 cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24436031&form=6&db=m Expression of PARP-1 and its active polymer PAR in prostate cancer and benign prostatic hyperplasia in Chinese patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24589464&form=6&db=m Poly (ADP-ribose) polymerase inhibitor: an evolving paradigm in the treatment of prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24627085&form=6&db=m Dynamic Regulation of Rad51 by E2F1 and p53 in Prostate Cancer Cells upon DrugInduced DNA Damage under Hypoxia. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24690568&form=6&db=m Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth. ongoing research,unassigned 3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24695460&form=6&db=m Downregulation of mTOR by lentivirus inhibits prostate cancer cell growth. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24764124&form=6&db=m Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24837011&form=6&db=m Effects of INPP4B gene transfection combined with PARP inhibitor on castration therapy-resistant prostate cancer cell line, PC3. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24847116&form=6&db=m Targeting poly(ADP-ribose) polymerase and the c-Myb-regulated DNA damage response pathway in castration-resistant prostate cancer. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24866151&form=6&db=m Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition. therapeutic application,unassigned 4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24886089&form=6&db=m DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells. causal interaction,diagnostic usage,unassigned 3,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25037599&form=6&db=m PARP-1 and CASP3 genes are up-regulated in LNCaP and PC-3 prostate cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25073909&form=6&db=m Induction of apoptosis in hormone-resistant human prostate cancer PC3 cells by inactivated Sendai virus. therapeutic application,unassigned 2,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25127709&form=6&db=m Synergistic loss of prostate cancer cell viability by coinhibition of HDAC and PARP. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25132269&form=6&db=m DNA damage response and prostate cancer: defects, regulation and therapeutic implications. therapeutic application,unassigned 3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25173886&form=6&db=m PARP-1 regulates epithelial-mesenchymal transition (EMT) in prostate tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25583815&form=6&db=m Olaparib effective in four advanced cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25682949&form=6&db=m Artocarpus altilis (Parkinson) Fosberg Extracts and Geranyl Dihydrochalcone Inhibit STAT3 Activity in Prostate Cancer DU145 Cells. ongoing research,unassigned 3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25808111&form=6&db=m Expression of nuclear matrix proteins binding matrix attachment regions in prostate cancer. PARP-1: New player in tumor progression. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25811344&form=6&db=m Sequences and combinations of multifaceted therapy in advanced prostate cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25865228&form=6&db=m Autoimmune response to PARP and BRCA1/BRCA2 in cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25904654&form=6&db=m Stratifying prostate patients for olaparib. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26014377&form=6&db=m Inhibition of Myeloid Cell Leukemia 1 and Activation of Caspases Are Critically Involved in Gallotannin-induced Apoptosis in Prostate Cancer Cells. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26026052&form=6&db=m The TMPRSS2-ERG Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP Inhibition. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26069882&form=6&db=m Role of PARP-1 in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26210103&form=6&db=m Molecular landscape of prostate cancer: implications for current clinical trials. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26258074&form=6&db=m Sustained Complete Response to Cytotoxic Therapy and the PARP Inhibitor Veliparib in Metastatic Castration-Resistant Prostate Cancer - A Case Report. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26277432&form=6&db=m In vivo studies of the PARP inhibitor, AZD-2281, in combination with fractionated radiotherapy: An exploration of the therapeutic ratio. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26353013&form=6&db=m SILAC-Based Mass Spectrometry Analysis Reveals That Epibrassinolide Induces Apoptosis via Activating Endoplasmic Reticulum Stress in Prostate Cancer Cells. causal interaction,unassigned 1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26476001&form=6&db=m Quercetin-6-C-?-D-glucopyranoside, natural analog of quercetin exhibits anti-prostate cancer activity by inhibiting Akt-mTOR pathway via aryl hydrocarbon receptor. ongoing research,unassigned 3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26510020&form=6&db=m DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26658963&form=6&db=m Olaparib Targets Some Advanced Prostate Cancers. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26792387&form=6&db=m PARP inhibition in castration-resistant prostate cancer. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26865580&form=6&db=m PARP inhibitor receives FDA breakthrough therapy designation in castration resistant prostate cancer: beyond germline BRCA mutations. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26887755&form=6&db=m Re: Expression of Nuclear Matrix Proteins Binding Matrix Attachment Regions in Prostate Cancer. PARP-1: New Player in Tumor Progression. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26908063&form=6&db=m The promising role of poly(ADP-ribose) polymerase inhibitors in prostate cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26909613&form=6&db=m Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27169997&form=6&db=m Molecular Pathways: Targeting DNA Repair Pathway Defects Enriched in Metastasis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27188668&form=6&db=m Targeting PARP in Prostate Cancer: Novelty, Pitfalls, and Promise. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27188669&form=6&db=m PARP Inhibition in Prostate Cancer: A Promising Approach. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27426307&form=6&db=m Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27524236&form=6&db=m Molecular mechanisms of synergistic induction of apoptosis by the combination therapy with hyperthermia and cisplatin in prostate cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27590317&form=6&db=m DNA Repair in Prostate Cancer: Biology and Clinical Implications. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27596623&form=6&db=m Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27600766&form=6&db=m Evaluation of the radiosensitizing potency of chemotherapeutic agents in prostate cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27686597&form=6&db=m PARP inhibitors and stratified treatment of prostate cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27687312&form=6&db=m PARP inhibition in BRCA2-mutated prostate cancer. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27720946&form=6&db=m 6-(3,4-Dihydro-1H-isoquinoline-2-yl)-N-(6-methoxypyridine-2-yl) nicotinamide-26 (DIMN-26) decreases cell proliferation by induction of apoptosis and downregulation of androgen receptor signaling in human prostate cancer cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27749330&form=6&db=m Targeting DNA Repair: The Role of PARP Inhibition in the Treatment of Castration-Resistant Prostate Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27994514&form=6&db=m The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28069876&form=6&db=m Targeting Plk1 to Enhance Efficacy of Olaparib in Castration-Resistant Prostate Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28119808&form=6&db=m Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28254167&form=6&db=m Design, synthesis and in vitro cytotoxicity studies of novel ?-carbolinium bromides. diagnostic usage,unassigned 3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28323658&form=6&db=m Changing face of metastatic prostate cancer: the law of diminishing returns holds true. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28383142&form=6&db=m Auraptene Induces Apoptosis via Myeloid Cell Leukemia 1-Mediated Activation of Caspases in PC3 and DU145 Prostate Cancer Cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28415632&form=6&db=m The combined effect of USP7 inhibitors and PARP inhibitors in hormone-sensitive and castration-resistant prostate cancer cells. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28450425&form=6&db=m Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28450426&form=6&db=m Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors. therapeutic application,unassigned 3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28500233&form=6&db=m Nanoformulation of Olaparib Amplifies PARP Inhibition and Sensitizes PTEN/TP53-Deficient Prostate Cancer to Radiation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28536297&form=6&db=m Androgen receptor inhibitor-induced "BRCAness" and PARP inhibition are synthetically lethal for castration-resistant prostate cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28540598&form=6&db=m PARP Inhibitors in Prostate Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28583748&form=6&db=m Development of PARP inhibitors in gynecological malignancies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28628830&form=6&db=m Breviscapine (BVP) inhibits prostate cancer progression through damaging DNA by minichromosome maintenance protein-7 (MCM-7) modulation. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28676700&form=6&db=m The multifaceted roles of PARP1 in DNA repair and chromatin remodelling. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28812304&form=6&db=m Management of Castration-Resistant, Taxane-Resistant Prostate Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28851861&form=6&db=m Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28895177&form=6&db=m A Novel Use for Olaparib for Treatment of Metastatic Castration-Recurrent Prostate Cancer. causal interaction,unassigned 3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28926548&form=6&db=m Prostate cancer: Potential of PARP inhibition plus ADT in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29063620&form=6&db=m Predictive value of epithelial-mesenchymal-transition (EMT) signature and PARP-1 in prostate cancer radioresistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29156794&form=6&db=m Salen-Mn compounds induces cell apoptosis in human prostate cancer cells through promoting AMPK activity and cell autophagy. unassigned - 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29200739&form=6&db=m A Study of the Anti-Cancer Effects of the Hexane Fraction of the Methanol Extract of Forsythiae Fructus. ongoing research,unassigned 3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29217266&form=6&db=m Auriculasin-induced ROS causes prostate cancer cell death via induction of apoptosis. unassigned - 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29261439&form=6&db=m Targeting Androgen Receptor and DNA Repair in Metastatic Castration-Resistant Prostate Cancer: Results From NCI 9012. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,2 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29465803&form=6&db=m Olaparib is effective in combination with, and as maintenance therapy after, first-line endocrine therapy in prostate cancer cells. therapeutic application,unassigned 1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29500400&form=6&db=m Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29526801&form=6&db=m BCL2-overexpressing prostate cancer cells rely on PARP1-dependent end-joining and are sensitive to combined PARP inhibitor and radiation therapy. therapeutic application,unassigned 4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29595348&form=6&db=m PARP inhibitors for homologous recombination-deficient prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29644451&form=6&db=m Emerging Therapies in Metastatic Prostate Cancer. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29767250&form=6&db=m Diosmetin suppresses human prostate cancer cell proliferation through the induction of apoptosis and cell cycle arrest. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29880291&form=6&db=m Olaparib combined with abiraterone in patients with metastatic castration-resistant prostate cancer: a randomised, double-blind, placebo-controlled, phase 2 trial. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29954730&form=6&db=m Abiraterone-Olaparib Combo Aids Men with mCRPC. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29955114&form=6&db=m Synthetic lethal therapies for cancer: what's next after PARP inhibitors? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29979319&form=6&db=m Relevance of poly (ADP-ribose) polymerase inhibitors in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30008594&form=6&db=m Proscillaridin A induces apoptosis, inhibits STAT3 activation and augments doxorubicin toxicity in prostate cancer cells. causal interaction,unassigned 3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30012171&form=6&db=m PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cells. therapeutic application,unassigned 4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30099369&form=6&db=m DNA Repair Gene Alterations and PARP Inhibitor Response in Patients With Metastatic Castration-Resistant Prostate Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30128030&form=6&db=m PARP9 is overexpressed in human breast cancer and promotes cancer cell migration. causal interaction,diagnostic usage,unassigned 2,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30131605&form=6&db=m BRCAness and prostate cancer: diagnostic and therapeutic considerations. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30195072&form=6&db=m Preliminary evaluation of a novel 18F-labeled PARP-1 ligand for PET imaging of PARP-1 expression in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30234108&form=6&db=m Aberrations of DNA Repair Pathways in Prostate Cancer: Future Implications for Clinical Practice? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30245085&form=6&db=m Mutational Profile of Aggressive, Localised Prostate Cancer from African Caribbean Men Versus European Ancestry Men. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30278883&form=6&db=m [DNA damage repair: An emerging strategy in metastatic prostate cancer]. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30499118&form=6&db=m Targeting genotoxic and proteotoxic stress-response pathways in human prostate cancer by clinically available PARP inhibitors, vorinostat and disulfiram. therapeutic application,unassigned 2,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30514390&form=6&db=m Activity of durvalumab plus olaparib in metastatic castration-resistant prostate cancer in men with and without DNA damage repair mutations. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30833416&form=6&db=m Response to olaparib in a PALB2 germline mutated prostate cancer and genetic events associated with resistance. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30880062&form=6&db=m Non-NAD-like PARP-1 inhibitors in prostate cancer treatment. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30890936&form=6&db=m Research Progress on PARP14 as a Drug Target. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30954315&form=6&db=m PARP Inhibitors for Advanced Prostate Cancer: Validating Predictive Biomarkers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31006810&form=6&db=m A novel CRISPR-engineered prostate cancer cell line defines the AR-V transcriptome and identifies PARP inhibitor sensitivities. therapeutic application,unassigned 2,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31049637&form=6&db=m [Molecular tumor board prostate cancer]. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31060606&form=6&db=m Similar incidence of DNA damage response pathway alterations between clinically localized and metastatic prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31075528&form=6&db=m Overexpressed ABCB1 Induces Olaparib-Taxane Cross-Resistance in Advanced Prostate Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31229626&form=6&db=m Buforin IIb induces androgen-independent prostate cancer cells apoptosis though p53 pathway in vitro. unassigned - 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31300540&form=6&db=m Loss of MAP3K7 Sensitizes Prostate Cancer Cells to CDK1/2 Inhibition and DNA Damage by Disrupting Homologous Recombination. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31334865&form=6&db=m The 25th Annual Prostate Cancer Foundation Scientific Retreat Report. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31357527&form=6&db=m PARP Inhibitors in Prostate Cancer—The Preclinical Rationale and Current Clinical Development. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31404966&form=6&db=m Clinical Development of PARP Inhibitors in Treating Metastatic Castration-Resistant Prostate Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31423128&form=6&db=m Induction of apoptosis and modulation of homologous recombination DNA repair pathway in prostate cancer cells by the combination of AZD2461 and valproic acid. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31439587&form=6&db=m PARP Inhibition Suppresses GR-MYCN-CDK5-RB1-E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31501807&form=6&db=m Acquired Resistance to Poly (ADP-ribose) Polymerase Inhibitor Olaparib in BRCA2-Associated Prostate Cancer Resulting From Biallelic BRCA2 Reversion Mutations Restores Both Germline and Somatic Loss-of-Function Mutations. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31565603&form=6&db=m Molecular Testing Identifies Determinants of Exceptional Response and Guides Precision Therapy in a Patient with Lethal, Treatment-emergent Neuroendocrine Prostate Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31582533&form=6&db=m The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31671654&form=6&db=m Analysis of Transcriptome, Selected Intracellular Signaling Pathways, Proliferation and Apoptosis of LNCaP Cells Exposed to High Leptin Concentrations. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,2 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31732654&form=6&db=m Clinical Evolution of Epithelial-Mesenchymal Transition in Human Carcinomas. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31796516&form=6&db=m Significance of BRCA2 and RB1 Co-loss in Aggressive Prostate Cancer Progression. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31806542&form=6&db=m The tip of the iceberg: predicting PARP inhibitor efficacy in prostate cancer. diagnostic usage,therapeutic application,unassigned 1,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31911855&form=6&db=m SGO1 induces proliferation and metastasis of prostate cancer through AKT-mediated signaling pathway. therapeutic application,unassigned 1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31916449&form=6&db=m Germline and somatic mutations in prostate cancer: focus on defective DNA repair, PARP inhibitors and immunotherapy. therapeutic application,unassigned 1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31932422&form=6&db=m Trop2 is a driver of metastatic prostate cancer with neuroendocrine phenotype via PARP1. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31978677&form=6&db=m Emerging treatments for metastatic castration-resistant prostate cancer: Immunotherapy, PARP inhibitors, and PSMA-targeted approaches. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32071115&form=6&db=m Detection of molecular signatures of homologous recombination deficiency in prostate cancer with or without BRCA1/2 mutations. therapeutic application,unassigned 1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32075054&form=6&db=m Sanggenol L Induces Apoptosis and Cell Cycle Arrest via Activation of p53 and Suppression of PI3K/Akt/mTOR Signaling in Human Prostate Cancer Cells. therapeutic application,unassigned 1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32086346&form=6&db=m Non-BRCA DNA Damage Repair Gene Alterations and Response to the PARP Inhibitor Rucaparib in Metastatic Castration-Resistant Prostate Cancer: analysis from the phase 2 TRITON2 study. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32117762&form=6&db=m PARP Inhibitors in Prostate and Urothelial Cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32123273&form=6&db=m Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32127357&form=6&db=m ATM Loss Confers Greater Sensitivity to ATR Inhibition than PARP Inhibition in Prostate Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32128485&form=6&db=m PARP inhibitor-induced torsades de pointes in long QT syndrome: a case report. causal interaction,unassigned 4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32171277&form=6&db=m Polyclonal BRCA2 mutations following carboplatin treatment confer resistance to the PARP inhibitor rucaparib in a patient with mCRPC: a case report. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32215055&form=6&db=m PARP inhibitor combinations in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32234758&form=6&db=m Honing in on PARPi Response in Prostate Cancer: from HR Pathway to Gene-by-Gene Granularity. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32258820&form=6&db=m Resistance Mechanisms to Taxanes and PARP Inhibitors in Advanced Prostate Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32342655&form=6&db=m Structurally unique PARP-1 inhibitors for the treatment of prostate cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32343890&form=6&db=m Olaparib for Metastatic Castration-Resistant Prostate Cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32367009&form=6&db=m PARP inhibitors as a new therapeutic option in metastatic prostate cancer: a systematic review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32378433&form=6&db=m Growth Inhibitory and Pro-Apoptotic Effects of Ornamental Pomegranate Extracts in Du145 Human Prostate Cancer Cells. causal interaction,unassigned 1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32427575&form=6&db=m A novel 3',5'-diprenylated chalcone induces concurrent apoptosis and GSDME-dependent pyroptosis through activating PKC?/JNK signal in prostate cancer. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32427631&form=6&db=m Poly(ADP-ribose) polymerase inhibitors in prostate and urothelial cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32457830&form=6&db=m Therapeutic Potential of Combining PARP Inhibitor and Immunotherapy in Solid Tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32462107&form=6&db=m CDK12-Altered Prostate Cancer: Clinical Features and Therapeutic Outcomes to Standard Systemic Therapies, Poly (ADP-Ribose) Polymerase Inhibitors, and PD-1 Inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32484346&form=6&db=m Design and Synthesis of a Trifunctional Molecular System "Programmed" to Block Epidermal Growth Factor Receptor Tyrosine Kinase, Induce High Levels of DNA Damage, and Inhibit the DNA Repair Enzyme (Poly(ADP-ribose) Polymerase) in Prostate Cancer Cells. therapeutic application,unassigned 2,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32487588&form=6&db=m Moving beyond PARP Inhibition in ATM-Deficient Prostate Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32521178&form=6&db=m PARP inhibitors in prostate cancer: time to narrow patient selection? causal interaction,unassigned 4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32636098&form=6&db=m DNA Repair and Prostate Cancer: A Field Ripe for Harvest. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32675592&form=6&db=m Targeting defective DNA repair in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32745972&form=6&db=m PARP inhibitors in castration-resistant prostate cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32758032&form=6&db=m The emerging role of PARP inhibitors in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32779949&form=6&db=m Identification of probe-quality degraders for Poly(ADP-ribose) polymerase-1 (PARP-1). causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32790034&form=6&db=m PARP Inhibitors and Prostate Cancer: To Infinity and Beyond BRCA. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32795228&form=6&db=m Rucaparib in Men With Metastatic Castration-Resistant Prostate Cancer Harboring a BRCA1 or BRCA2 Gene Alteration. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32814685&form=6&db=m When and How to Use PARP Inhibitors in Prostate Cancer: A Systematic Review of the Literature with an Update on On-Going Trials. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32850156&form=6&db=m Poly (ADP-Ribose) Polymerase 1 Protein Expression in Normal Pancreas and Pancreatic Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32870734&form=6&db=m BRCA1 Versus BRCA2 and PARP Inhibitor Sensitivity in Prostate Cancer: More Different Than Alike? diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32893185&form=6&db=m PARP Inhibitors in Prostate Cancer: A Promise Delivered. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32982407&form=6&db=m PARP Inhibitors in Metastatic Prostate Cancer: Evidence to Date. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32997692&form=6&db=m Impact of mutations in homologous recombination repair genes on treatment outcomes for metastatic castration resistant prostate cancer. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33012578&form=6&db=m Efficacy of PARP Inhibition in Metastatic Castration-resistant Prostate Cancer is Very Different with Non-BRCA DNA Repair Alterations: Reconstructing Prespecified Endpoints for Cohort B from the Phase 3 PROfound Trial of Olaparib. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33021139&form=6&db=m Genetic biomarkers to guide poly(ADP-ribose) polymerase inhibitor precision treatment of prostate cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33044685&form=6&db=m Poly(ADP-Ribose) Polymerase Inhibitors in Prostate Cancer: Molecular Mechanisms, and Preclinical and Clinical Data. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33084183&form=6&db=m PARP inhibition in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33112397&form=6&db=m Activity of Platinum-Based Chemotherapy in Patients With Advanced Prostate Cancer With and Without DNA Repair Gene Aberrations. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33158305&form=6&db=m Targeting DNA Damage Response in Prostate and Breast Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33176972&form=6&db=m Advanced Prostate Cancer with ATM Loss: PARP and ATR Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33208392&form=6&db=m Beware Liquid Biopsies to Guide PARP Blockade. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33233320&form=6&db=m Therapeutic Potential of PARP Inhibitors in the Treatment of Metastatic Castration-Resistant Prostate Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33262506&form=6&db=m Synergistic action of combined PARP and ATR inhibition in prostate cancer with ATM loss. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33263430&form=6&db=m DNA damage repair gene mutation testing and genetic counseling in men with/without prostate cancer: a systematic review. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33301988&form=6&db=m Covid-19 pathogenesis in prostatic cancer and TMPRSS2-ERG regulatory genetic pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33358233&form=6&db=m Reply to Johann S. de Bono, Maha Hussain, and Jinyu Kang's Letter to the Editor re: Konrad H. Stopsack. Efficacy of PARP Inhibition in Metastatic Castration-resistant Prostate Cancer is Very Different with Non-BRCA DNA Repair Alterations: Reconstructing Prespecified Endpoints for Cohort B from the Phase 3 PROfound Trial of Olaparib. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.09.024. therapeutic application,unassigned 2,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33358234&form=6&db=m Re: Konrad H. Stopsack. Efficacy of PARP Inhibition in Metastatic Castration-resistant Prostate Cancer is Very Different with Non-BRCA DNA Repair Alterations: Reconstructing Prespecified Endpoints for Cohort B from the Phase 3 PROfound Trial of Olaparib. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.09.024. therapeutic application,unassigned 3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33369720&form=6&db=m Evolving Role of Immunotherapy in Metastatic Castration Refractory Prostate Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33406057&form=6&db=m PARP inhibitors in prostate cancer: practical guidance for busy clinicians. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33462368&form=6&db=m Homologous recombination deficiency (HRD) score in germline BRCA2- versus ATM-altered prostate cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33517260&form=6&db=m PARP Inhibitors in Prostate Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33557050&form=6&db=m Treating Prostate Cancer by Antibody-Drug Conjugates. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33589795&form=6&db=m Response prediction biomarkers and drug combinations of PARP inhibitors in prostate cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33630412&form=6&db=m Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33683975&form=6&db=m Ionizing Radiation Combined with PARP1 Inhibitor Reduces Radioresistance in Prostate Cancer with RB1/TP53 Loss. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33722420&form=6&db=m Untangling the PROfound Trial for Advanced Prostate Cancer: Is There Really a Role for Olaparib? causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33742189&form=6&db=m Resistance to second-generation androgen receptor antagonists in prostate cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33773874&form=6&db=m Treatment and Patient Selection for Patients with Metastatic Castration-resistant Prostate After Progression on Docetaxel and Abiraterone/Enzalutamide: When to Play Your CARD and When to Do Your PARP. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33781305&form=6&db=m Prostate cancer and PARP inhibitors: progress and challenges. therapeutic application,unassigned 4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33818052&form=6&db=m Integrating PARP Inhibitors Into Advanced Prostate Cancer Therapeutics. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33827356&form=6&db=m Olaparib and rucaparib for the treatment of DNA repair-deficient metastatic castration-resistant prostate cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33866131&form=6&db=m Drug and molecular radiotherapy combinations for metastatic castration resistant prostate cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33887280&form=6&db=m Age-related activity of Poly (ADP-Ribose) Polymerase (PARP) in men with localized prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,3,1 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33905671&form=6&db=m NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33909097&form=6&db=m Pharmacokinetics and safety of rucaparib in patients with advanced solid tumors and hepatic impairment. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33921501&form=6&db=m Quo Vadis Advanced Prostate Cancer Therapy? Novel Treatment Perspectives and Possible Future Directions. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34045297&form=6&db=m Biomarkers Associating with PARP Inhibitor Benefit in Prostate Cancer in the TOPARP-B Trial. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34050966&form=6&db=m Radiosynthesis of 3 H- and 14 C-labeled Veliparib. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34066020&form=6&db=m The Role of PARP Inhibitors in the Treatment of Prostate Cancer: Recent Advances in Clinical Trials. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34102435&form=6&db=m Homologous recombination repair gene mutations in Chinese localized and locally advanced prostate cancer patients. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34102978&form=6&db=m Recent Development and Future Prospects of Molecular Targeted Therapy in Prostate Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34158347&form=6&db=m PARP and CDK4/6 Inhibitor Combination Therapy Induces Apoptosis and Suppresses Neuroendocrine Differentiation in Prostate Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34168048&form=6&db=m ATR Inhibition Induces CDK1-SPOP Signaling and Enhances Anti-PD-L1 Cytotoxicity in Prostate Cancer. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34226663&form=6&db=m A transcriptomic model for homologous recombination deficiency in prostate cancer. causal interaction,unassigned 4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34256353&form=6&db=m PARP inhibitors in advanced prostate cancer: when to use them? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34282527&form=6&db=m Real-World Treatment Patterns and Overall Survival of Patients with Metastatic Castration-Resistant Prostate Cancer in the US Prior to PARP Inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34325986&form=6&db=m Mutations in TP53 or DNA damage repair genes define poor prognostic subgroups in primary prostate cancer. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34376738&form=6&db=m Exploring the selectivity of guanine scaffold in anticancer drug development by computational repurposing approach. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34377000&form=6&db=m Targeting c-MET to Enhance the Efficacy of Olaparib in Prostate Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34377227&form=6&db=m Development of PARP inhibitor combinations for castration resistant prostate cancer unselected for homologous recombination repair mutations. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34388386&form=6&db=m Talazoparib monotherapy in metastatic castration-resistant prostate cancer with DNA repair alterations (TALAPRO-1): an open-label, phase 2 trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34413130&form=6&db=m CX-5461 sensitises DNA damage repair proficient castrate-resistant prostate cancer to PARP inhibition. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34440228&form=6&db=m Therapeutic Potential of PARP Inhibitors in the Treatment of Gastrointestinal Cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27722009&form=6&db=m Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity. causal interaction,unassigned 2,0 2.4.2.30 Protein Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911337&form=6&db=m Ageing and PARP. causal interaction,unassigned 2,0 2.4.2.30 protein-tyrosine-phosphatase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25823847&form=6&db=m A cell type-specific role of protein tyrosine phosphatase non-receptor type 2 in regulating ER stress signalling. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28224182&form=6&db=m PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33099187&form=6&db=m Therapeutic options following second-line platinum-based chemotherapy in patients with recurrent ovarian cancer: Comparison of active surveillance and maintenance treatment. causal interaction,unassigned 4,0 2.4.2.30 protoporphyrin ferrochelatase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26954031&form=6&db=m Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Pseudomonas Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=112058&form=6&db=m Production of exoenzyme S during Pseudomonas aeruginosa infections of burned mice. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Pseudomonas Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2988944&form=6&db=m Use of transposon mutants to assess the role of exoenzyme S in chronic pulmonary disease due to Pseudomonas aeruginosa. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Pseudorabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34037418&form=6&db=m Inhibition of PARP1 Dampens Pseudorabies Virus Infection through DNA Damage-Induced Antiviral Innate Immunity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.4.2.30 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12102657&form=6&db=m Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31755591&form=6&db=m Poly(ADP-ribose) polymerase-1 depletion enhances the severity of inflammation in an imiquimod-induced model of psoriasis. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12594058&form=6&db=m Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12853070&form=6&db=m Systemic poly(ADP-ribose) polymerase-1 activation, chronic inflammation, and oxidative stress in COPD patients. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16289039&form=6&db=m Theophylline prevents NAD+ depletion via PARP-1 inhibition in human pulmonary epithelial cells. causal interaction,unassigned 1,0 2.4.2.30 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17643414&form=6&db=m Flavone as PARP-1 inhibitor: its effect on lipopolysaccharide induced gene-expression. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19321592&form=6&db=m Poly (ADP-ribose) polymerase-1-inhibiting flavonoids attenuate cytokine release in blood from male patients with chronic obstructive pulmonary disease or type 2 diabetes. causal interaction,unassigned 4,0 2.4.2.30 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19962977&form=6&db=m Inhibition of acute pulmonary and systemic inflammation by 1,7-dimethylxanthine. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23894640&form=6&db=m Increased DNA damage in progression of COPD: a response by poly(ADP-ribose) polymerase-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.4.2.30 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28974953&form=6&db=m Poly(ADP-Ribose)Polymerase-1 in Lung Inflammatory Disorders: A Review. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29355504&form=6&db=m PARP-1 inhibition ameliorates elastase induced lung inflammation and emphysema in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.4.2.30 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33063092&form=6&db=m Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33187221&form=6&db=m Increased PARP Activity and DNA Damage in NSCLC Patients: The Influence of COPD. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1 2.4.2.30 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8643465&form=6&db=m Excitotoxicity in the lung: N-methyl-D-aspartate-induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly(ADP-ribose) polymerase. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1380762&form=6&db=m Taurine and niacin offer a novel therapeutic modality in prevention of chemically-induced pulmonary fibrosis in hamsters. unassigned - 2.4.2.30 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31164820&form=6&db=m Effects of PARP-1 Deficiency and Histamine H4 Receptor Inhibition in an Inflammatory Model of Lung Fibrosis in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Purpura http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29497996&form=6&db=m Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura. causal interaction,unassigned 3,0 2.4.2.30 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18006925&form=6&db=m DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. ongoing research,unassigned 2,0 2.4.2.30 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20559012&form=6&db=m Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study. diagnostic usage,unassigned 3,0 2.4.2.30 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22864776&form=6&db=m Colorectal cancers differ in respect of PARP-1 protein expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.4.2.30 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28497749&form=6&db=m PARP inhibitors and chemoradiation for rectal cancer. therapeutic application,unassigned 4,0 2.4.2.30 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31326434&form=6&db=m Development of renal failure in PargParp-1 null and Timm23 hypomorphic mice. causal interaction,unassigned 2,0 2.4.2.30 Reoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2174674&form=6&db=m Reovirus transport--studies using lymphocytosis promoting factor. ongoing research,unassigned 1,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9535773&form=6&db=m Cellular responses to DNA damage in the absence of Poly(ADP-ribose) polymerase. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10350529&form=6&db=m Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10374629&form=6&db=m Neuroprotective effects of poly (ADP-ribose) polymerase inhibitors in transient focal cerebral ischemia of rats. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10424667&form=6&db=m The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10692558&form=6&db=m BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase. therapeutic application,unassigned 1,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10856830&form=6&db=m Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model? causal interaction,unassigned 1,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10947157&form=6&db=m Inhibition of the activity of poly (ADP-ribose) polymerase in ischemia-reperfusion injury. causal interaction,unassigned 4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11149897&form=6&db=m Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. causal interaction,unassigned 4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11748298&form=6&db=m Detection of poly(ADP-ribose) polymerase activation in oxidatively stressed cells and tissues using biotinylated NAD substrate. unassigned - 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11786525&form=6&db=m Poly(ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11954828&form=6&db=m Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice. causal interaction,ongoing research,unassigned 4,3,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12011985&form=6&db=m Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12114629&form=6&db=m Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. causal interaction,unassigned 3,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12181167&form=6&db=m Poly(ADP-ribose) polymerase triggers the microvascular mechanisms of hepatic ischemia-reperfusion injury. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12663936&form=6&db=m Poly(ADP-ribose) polymerase during reperfusion after transient forebrain ischemia: its role in brain edema and cell death. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12686864&form=6&db=m The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12688429&form=6&db=m Beneficial effects of poly (ADP-ribose) polymerase inhibition against the reperfusion injury in heart transplantation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12892811&form=6&db=m Poly(ADP-ribose) polymerase inhibition improves postischemic myocardial function after cardioplegia-cardiopulmonary bypass. causal interaction,unassigned 4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14571322&form=6&db=m Absence of poly(ADP-ribose)polymerase-1 alters nuclear factor-kappa B activation and gene expression of apoptosis regulators after reperfusion injury. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14670820&form=6&db=m Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14678748&form=6&db=m Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity. causal interaction,unassigned 1,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14770035&form=6&db=m Activation of poly(ADP-ribose) polymerase in circulating leukocytes during myocardial infarction. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14976461&form=6&db=m Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15072913&form=6&db=m Inhibition of poly(adenosine diphosphate-ribose) polymerase decreases long-term histologic damage in testicular ischemia-reperfusion injury. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075179&form=6&db=m Poly(ADP-ribose) polymerase and renal hypothermic preservation injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15110646&form=6&db=m Correlation of morphological findings with functional reserve in the aging donor: role of the poly (ADP-ribose) polymerase. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15213249&form=6&db=m A new, potent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced aging. causal interaction,unassigned 4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15450800&form=6&db=m A nonradiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): application to inhibitor identification and evaluation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15691675&form=6&db=m Poly(ADP-ribose) polymerase inhibition attenuates biventricular reperfusion injury after orthotopic heart transplantation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15866623&form=6&db=m Role of poly-(ADP-ribose) polymerase in transplant acute tubular necrosis and its relationship with delayed renal function. unassigned - 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911336&form=6&db=m Poly(ADP-ribosyl)ation in asthma and other lung diseases. causal interaction,unassigned 4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15953818&form=6&db=m Poly(ADP-ribose) polymerase: the nuclear target in signal transduction and its role in brain ischemia-reperfusion injury. causal interaction,unassigned 4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16245211&form=6&db=m Inhibition of poly(ADP-ribose) polymerase activity protects hippocampal cells against morphological and ultrastructural alteration evoked by ischemia-reperfusion injury. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16480745&form=6&db=m In vitro effect of the potent poly(ADP-ribose) polymerase (PARP) inhibitor INO-1001 alone and in combination with aspirin, eptifibatide, tirofiban, enoxaparin or alteplase on haemostatic parameters. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16935310&form=6&db=m Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612561&form=6&db=m Effect of PJ-34 PARP-inhibitor on rat liver microcirculation and antioxidant status. unassigned - 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17700164&form=6&db=m Improved poststorage cardiac function by poly (ADP-ribose) polymerase inhibition: role of phosphatidylinositol 3-kinase Akt pathway. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18836068&form=6&db=m A novel and orally active poly(ADP-ribose) polymerase inhibitor, KR-33889 [2-[methoxycarbonyl(4-methoxyphenyl) methylsulfanyl]-1H-benzimidazole-4-carboxylic acid amide], attenuates injury in in vitro model of cell death and in vivo model of cardiac ischemia. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20132957&form=6&db=m Postischemic poly (ADP-ribose) polymerase (PARP) inhibition reduces ischemia reperfusion injury in a hind-limb ischemia model. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20881608&form=6&db=m Minocycline Protects Cardiac Myocytes Against Simulated Simulated Ischemia-Reperfusion Injury by Inhibiting Poly(ADP-ribose) Polymerase-1. therapeutic application,unassigned 2,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21151457&form=6&db=m Neuroprotective Properties of Picroside II in a Rat Model of Focal Cerebral Ischemia. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21164558&form=6&db=m Effects of 3-aminobenzamide on unilateral testicular ischemia-reperfusion injury: what is the role of PARP inhibition? ongoing research,unassigned 1,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21870266&form=6&db=m Quantification of PARP Activity in Human Tissues: Ex Vivo Assays in Blood Cells and Immunohistochemistry in Human Biopsies. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22168830&form=6&db=m Protective effect of cardioplegia with poly (ADP-ribose) polymerase-1 inhibitor against myocardial ischemia-reperfusion injury: in vitro study of isolated rat heart model. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23159776&form=6&db=m Poly(ADP-ribose) polymerase inhibition prevents reactive oxygen species induced inhibition of aldehyde dehydrogenase2 activity. therapeutic application,unassigned 4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23756954&form=6&db=m Investigating the Effect of the Poly(Adp-ribose) Polymerase Inhibitor 5-aminoisoquinolinone and the Na+-H+ Exchanger Inhibitor Zoniporide on Isolated Perfused Rat Hearts during Ischemia-reperfusion Injury. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23846805&form=6&db=m Continuous inhibition of poly(ADP-ribose) polymerase does not reduce reperfusion injury in isolated rat heart. therapeutic application,unassigned 4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24842055&form=6&db=m Modulation of Poly(ADP-Ribose) Polymerase-1 (PARP-1)-Mediated Oxidative Cell Injury by Ring Finger Protein 146 (RNF146) in Cardiac Myocytes. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24940413&form=6&db=m Effect of cilostazol pretreatment on the PARP/AIF-mediated apoptotic pathway in rat cerebral ischemia-reperfusion models. therapeutic application,unassigned 2,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25168103&form=6&db=m Protective effects of nigranoic acid on cerebral ischemia-reperfusion injury and its mechanism involving apoptotic signaling pathway. therapeutic application,unassigned 1,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25388944&form=6&db=m Poly(ADP-ribose) polymerase 1 activation links ischemic acute kidney injury to interstitial fibrosis. causal interaction,unassigned 4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25954991&form=6&db=m Hydrogen-rich saline reduces cell death through inhibition of DNA oxidative stress and overactivation of poly (ADP-ribose) polymerase-1 in retinal ischemia-reperfusion injury. causal interaction,unassigned 2,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26040949&form=6&db=m The activity and inhibition of poly(ADP-ribose) polymerase-1 in equine peripheral blood mononuclear cells in vitro. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26355684&form=6&db=m Matrix Metalloproteinase-2 (MMP-2) Gene Deletion Enhances MMP-9 Activity, Impairs PARP-1 Degradation, and Exacerbates Hepatic Ischemia and Reperfusion Injury in Mice. causal interaction,ongoing research,unassigned 2,2,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28695500&form=6&db=m Quantification of PARP Activity in Human Tissues: Ex Vivo Assays in Blood Cells and Immunohistochemistry in Human Biopsies. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29043098&form=6&db=m Spermidine is protective against kidney ischemia and reperfusion injury through inhibiting DNA nitration and PARP1 activation. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29968072&form=6&db=m Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31929757&form=6&db=m 25-Hydroxycholesterol protects against myocardial ischemia-reperfusion injury via inhibiting PARP activity. therapeutic application,unassigned 2,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32295316&form=6&db=m Therapeutic Strategies and Biomarkers to Modulate PARP Activity for Targeted Cancer Therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33178190&form=6&db=m Poly (ADP-Ribose) Polymerase Inhibitor Treatment as a Novel Therapy Attenuating Renal Ischemia-Reperfusion Injury. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34124031&form=6&db=m Sp1 Targeted PARP1 Inhibition Protects Cardiomyocytes From Myocardial Ischemia-Reperfusion Injury via Downregulation of Autophagy. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34131409&form=6&db=m MiR-124 Negatively Regulated PARP1 to Alleviate Renal Ischemia-reperfusion Injury by Inhibiting TNF?/RIP1/RIP3 Pathway. causal interaction,unassigned 2,0 2.4.2.30 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911336&form=6&db=m Poly(ADP-ribosyl)ation in asthma and other lung diseases. causal interaction,unassigned 4,0 2.4.2.30 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19651868&form=6&db=m Characterization of a unique ADP-ribosyltransferase of Mycoplasma penetrans. unassigned - 2.4.2.30 Respiratory Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12706764&form=6&db=m [Acute poisoning by chemical warfare agent: sulfur mustard] therapeutic application,unassigned 4,0 2.4.2.30 Respiratory Syncytial Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10979896&form=6&db=m Pertussis toxin sensitization alters the pathogenesis of subsequent respiratory syncytial virus infection. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Respiratory Tract Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2512841&form=6&db=m Pseudomonas aeruginosa exoenzyme S as a pathogenic determinant in respiratory infections. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Respiratory Tract Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10803255&form=6&db=m [Humoral reaction to Bordetella pertussis antigens: pertussis toxin, filamentous hemagglutinin and lipopolysaccharide in children with clinical symptoms of whooping cough. I. Antibody level for B pertussis antigens in children without respiratory tract infection symptoms] causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.4.2.30 Respiratory Tract Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15155640&form=6&db=m Suppression of serum antibody responses by pertussis toxin after respiratory tract colonization by Bordetella pertussis and identification of an immunodominant lipoprotein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Respiratory Tract Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17242062&form=6&db=m Pertussis toxin targets airway macrophages to promote Bordetella pertussis infection of the respiratory tract. causal interaction,unassigned 2,0 2.4.2.30 Respiratory Tract Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18765723&form=6&db=m Pertussis toxin inhibits early chemokine production to delay neutrophil recruitment in response to Bordetella pertussis respiratory tract infection in mice. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Respiratory Tract Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20120949&form=6&db=m [The frequency of detection of IgA, IgG and IgM antibodies to pertussis toxin in patients with respiratory tract infections in Poland] causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Respiratory Tract Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21115396&form=6&db=m Pertussis toxin permeabilization enhances the traversal of Escherichia coli K1, macrophages, and monocytes in a cerebral endothelial barrier model in vitro. ongoing research,unassigned 2,0 2.4.2.30 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17881537&form=6&db=m Excessive activation of poly(ADP-ribose) polymerase contributes to inherited photoreceptor degeneration in the retinal degeneration 1 mouse. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18982459&form=6&db=m Photoreceptor cell death mechanisms in inherited retinal degeneration. diagnostic usage,unassigned 3,0 2.4.2.30 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21124852&form=6&db=m PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21705688&form=6&db=m SIMULTANEOUS CELL DEATH AND UPREGULATION OF POLY(ADP-RIBOSE) POLYMERASE-1 (PARP-1) EXPRESSION IN EARLY POSTNATAL MOUSE RETINA. unassigned - 2.4.2.30 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22481856&form=6&db=m N -ethyl- N -nitrosourea induces retinal photoreceptor damage in adult rats. causal interaction,unassigned 1,0 2.4.2.30 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27699246&form=6&db=m MUTYH promotes oxidative microglial activation and inherited retinal degeneration. causal interaction,unassigned 3,0 2.4.2.30 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28004814&form=6&db=m Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31451894&form=6&db=m Drug repurposing studies of PARP inhibitors as a new therapy for inherited retinal degeneration. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32816354&form=6&db=m Intravitreal administration of adalimumab delays retinal degeneration in rd10 mice. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33481867&form=6&db=m Fluorescent detection of PARP activity in unfixed tissue. diagnostic usage,unassigned 1,0 2.4.2.30 Retinal Detachment http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32478624&form=6&db=m PJ34 Protects Photoreceptors from Cell Death by Inhibiting PARP-1 Induced Parthanatos after Experimental Retinal Detachment. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Retinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17881537&form=6&db=m Excessive activation of poly(ADP-ribose) polymerase contributes to inherited photoreceptor degeneration in the retinal degeneration 1 mouse. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Retinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30973576&form=6&db=m PARP Inhibitor Protects Against Chronic Hypoxia/Reoxygenation-Induced Retinal Injury by Regulation of MAPKs, HIF1?, Nrf2, and NF?B. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Retinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31494107&form=6&db=m Poly(ADP-Ribose) Polymerase-1 inhibition potentiates cell death and phosphorylation of DNA damage response proteins in oxidative stressed retinal cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28723922&form=6&db=m Temporal progression of PARP activity in the Prph2 mutant rd2 mouse: Neuroprotective effects of the PARP inhibitor PJ34. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27551530&form=6&db=m Efficacy of PARP inhibition in Pde6a mutant mouse models for retinitis pigmentosa depends on the quality and composition of individual human mutations. ongoing research,unassigned 2,0 2.4.2.30 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28004814&form=6&db=m Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31451894&form=6&db=m Drug repurposing studies of PARP inhibitors as a new therapy for inherited retinal degeneration. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32744119&form=6&db=m Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation. unassigned - 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9454737&form=6&db=m cAMP increasing agents attenuate the generation of apoptosis by etoposide in promonocytic leukemia cells. causal interaction,unassigned 1,0 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9751262&form=6&db=m p53-independent dephosphorylation and cleavage of retinoblastoma protein during tamoxifen-induced apoptosis in human breast carcinoma cells. unassigned - 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10075737&form=6&db=m Caspase-dependent activation of calpain during drug-induced apoptosis. therapeutic application,unassigned 1,0 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10096557&form=6&db=m Dysregulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1/MDA6 increases the susceptibility of human leukemia cells (U937) to 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial dysfunction and apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10572626&form=6&db=m Caspase-3 activation during the process of apoptosis induced by a vacuolar type H(+)-ATPase inhibitor. unassigned - 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10574992&form=6&db=m Transcriptional down-regulation of poly(ADP-ribose) polymerase gene expression by E1A binding to pRb proteins protects murine keratinocytes from radiation-induced apoptosis. ongoing research,unassigned 3,0 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10626732&form=6&db=m Fas-mediated apoptosis in T cells involves the dephosphorylation of the retinoblastoma protein by type 1 protein phosphatases. unassigned - 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11688977&form=6&db=m Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells. therapeutic application,unassigned 2,0 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839953&form=6&db=m The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12851702&form=6&db=m Sodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15897598&form=6&db=m Novel histone deacetylase inhibitors in the treatment of thyroid cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16965632&form=6&db=m Induction of cell cycle changes and modulation of apoptogenic/anti-apoptotic and extracellular signaling regulatory protein expression by water extracts of I'm-Yunity (PSP). unassigned - 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17876565&form=6&db=m Inhibitory effects of fenofibrate on apoptosis and cell proliferation in human endothelial cells in high glucose. diagnostic usage,unassigned 2,0 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17898295&form=6&db=m The proteasome inhibitor bortezomib induces apoptosis in human retinoblastoma cell lines in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19759913&form=6&db=m Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners. ongoing research,unassigned 1,0 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19879751&form=6&db=m Interferon-lambda induces G1 phase arrest or apoptosis in oesophageal carcinoma cells and produces anti-tumour effects in combination with anti-cancer agents. unassigned - 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20811699&form=6&db=m Histone deacetylase inhibitors valproic acid and depsipeptide sensitize retinoblastoma cells to radiotherapy by increasing H2AX phosphorylation and p53 acetylation-phosphorylation. therapeutic application,unassigned 1,0 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26634655&form=6&db=m LRP1 Regulates Retinal Angiogenesis by Inhibiting PARP-1 Activity and Endothelial Cell Proliferation. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27600289&form=6&db=m d-3-Deoxy-dioctanoylphosphatidylinositol induces cytotoxicity in human MCF-7 breast cancer cells via a mechanism that involves downregulation of the D-type cyclin-retinoblastoma pathway. unassigned - 2.4.2.30 Retinopathy of Prematurity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15202016&form=6&db=m Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8293037&form=6&db=m Differentiation of BA-HAN-1C rhabdomyosarcoma cells is controlled by a pertussis toxin sensitive signaling pathway. therapeutic application,unassigned 1,0 2.4.2.30 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23913164&form=6&db=m Tyrosyl-DNA phosphodiesterase 1 (TDP1) and Poly (ADP-Ribose) Polymerase-1 (PARP1) deficiency are cytotoxic to rhabdomyosarcoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30067444&form=6&db=m Enhancement of Soft Tissue Sarcoma Cell Radiosensitivity by Poly(ADP-ribose) Polymerase-1 Inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30357520&form=6&db=m PARP inhibitors affect growth, survival and radiation susceptibility of human alveolar and embryonal rhabdomyosarcoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31031007&form=6&db=m Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish. therapeutic application,unassigned 4,0 2.4.2.30 Rhabdomyosarcoma, Alveolar http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Rhabdomyosarcoma, Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30357520&form=6&db=m PARP inhibitors affect growth, survival and radiation susceptibility of human alveolar and embryonal rhabdomyosarcoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12083777&form=6&db=m Identification of autoantibodies associated with systemic lupus erythematosus. diagnostic usage,unassigned 3,0 2.4.2.30 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17543300&form=6&db=m Involvement of chemical mediators in nasal allergic responses of HDC-KO mice. ongoing research,unassigned 1,0 2.4.2.30 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24180296&form=6&db=m Investigation of poly (ADP-ribose) polymerase-1 genetic variants as a possible risk for allergic rhinitis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 2.4.2.30 ring-type e3 ubiquitin transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17318223&form=6&db=m Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 ring-type e3 ubiquitin transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19336573&form=6&db=m High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 ring-type e3 ubiquitin transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25416589&form=6&db=m Identification by array comparative genomic hybridization of a new amplicon on chromosome 17q highly recurrent in BRCA1 mutated triple negative breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 2.4.2.30 ring-type e3 ubiquitin transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26100884&form=6&db=m Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 ring-type e3 ubiquitin transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30022119&form=6&db=m Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 ring-type e3 ubiquitin transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30656896&form=6&db=m BRCA1 deficiency and synthetic lethality in leukemias; not only gene mutation matters. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 ring-type e3 ubiquitin transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31329989&form=6&db=m Synthetic lethality between BRCA1 deficiency and poly(ADP-ribose) polymerase inhibition is modulated by processing of endogenous oxidative DNA damage. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 ring-type e3 ubiquitin transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33730584&form=6&db=m DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1. causal interaction,unassigned 2,0 2.4.2.30 rna-directed dna polymerase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15545322&form=6&db=m Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 rna-directed dna polymerase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16436506&form=6&db=m PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres. causal interaction,unassigned 3,0 2.4.2.30 Rubella http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33928900&form=6&db=m Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019. diagnostic usage,unassigned 2,0 2.4.2.30 Salmonella Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11029688&form=6&db=m Salmonella induces macrophage death by caspase-1-dependent necrosis. unassigned - 2.4.2.30 Salmonella Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20515923&form=6&db=m Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Salmonella Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28544771&form=6&db=m Quantitative proteomic analysis of host epithelial cells infected by Salmonella enterica serovar Typhimurium. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1985936&form=6&db=m Regulation of transmembrane signal transduction of insulin-like growth factor II by competence type growth factors or viral ras p21. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19155307&form=6&db=m IFN regulatory factor 8 sensitizes soft tissue sarcoma cells to death receptor-initiated apoptosis via repression of FLICE-like protein expression. therapeutic application,unassigned 1,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20490796&form=6&db=m Doxorubicin-induced suppression of poly(ADP-ribose) polymerase-1 (PARP-1) activity and expression and its implication for PARP inhibitors in clinical trials. diagnostic usage,therapeutic application,unassigned 1,2,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23833192&form=6&db=m The RNA-binding Protein Fused in Sarcoma (FUS) Functions Downstream of Poly(ADP-ribose) Polymerase (PARP) in Response to DNA Damage. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25708226&form=6&db=m PARP inhibitors: A new era of targeted therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26680929&form=6&db=m Differential Sensitivity of Taxol-induced Apoptosis in U2OS and SaOS2 Osteogenic Sarcoma Cells. causal interaction,diagnostic usage,unassigned 1,1,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27643881&form=6&db=m Individual and Combined Expression of DNA Damage Response Molecules PARP1, ?H2AX, BRCA1, and BRCA2 Predict Shorter Survival of Soft Tissue Sarcoma Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28399901&form=6&db=m Activity of trabectedin and the PARP inhibitor rucaparib in soft-tissue sarcomas. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454547&form=6&db=m PARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29582320&form=6&db=m Soft tissue sarcomas: new opportunity of treatment with PARP inhibitors? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30067444&form=6&db=m Enhancement of Soft Tissue Sarcoma Cell Radiosensitivity by Poly(ADP-ribose) Polymerase-1 Inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30217671&form=6&db=m Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30357520&form=6&db=m PARP inhibitors affect growth, survival and radiation susceptibility of human alveolar and embryonal rhabdomyosarcoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31131495&form=6&db=m PARP1 expression in soft tissue sarcomas is a poor-prognosis factor and a new potential therapeutic target. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32863940&form=6&db=m Molecular signatures of BRCAness analysis identifies PARP inhibitor Niraparib as a novel targeted therapeutic strategy for soft tissue Sarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,4 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32963243&form=6&db=m Sarcoma stratification by combined pH2AX and MAP17 (PDZK1IP1) levels for a better outcome on doxorubicin plus olaparib treatment. therapeutic application,unassigned 3,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32987654&form=6&db=m Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA. therapeutic application,unassigned 4,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33927108&form=6&db=m Next-generation sequencing for the management of sarcomas with no known driver mutations. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34085099&form=6&db=m PARP inhibition in UV-associated angiosarcoma preclinical models. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,4,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34178990&form=6&db=m MCM4 Is a Novel Biomarker Associated With Genomic Instability, BRCAness Phenotype, and Therapeutic Potentials in Soft-Tissue Sarcoma. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34413129&form=6&db=m SLFN11 is widely expressed in pediatric sarcoma and induces variable sensitization to replicative stress caused by DNA damaging agents. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1320624&form=6&db=m Expression of functional Y1 receptors for neuropeptide Y in human Ewing's sarcoma cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2217729&form=6&db=m Constraints to DNA unwinding near radiation-induced strand breaks in Ewing's sarcoma cells. causal interaction,unassigned 1,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7671228&form=6&db=m Radiation-induced apoptosis of Ewing's sarcoma cells: DNA fragmentation and proteolysis of poly(ADP-ribose) polymerase. ongoing research,unassigned 2,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7784072&form=6&db=m Co-regulated expression of dbl and poly(ADP-ribose) polymerase in Ewing's sarcoma cells and dbl-transformed NIH3T3 fibroblasts. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10435618&form=6&db=m Regulation of the human poly(ADP-ribose) polymerase promoter by the ETS transcription factor. causal interaction,diagnostic usage,unassigned 3,2,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11956622&form=6&db=m Poly(ADP-ribose) polymerase turnover alterations do not contribute to PARP overexpression in Ewing's sarcoma cells. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11973649&form=6&db=m Differential regulation of the response to DNA damage in Ewing's sarcoma cells by ETS1 and EWS/FLI-1. causal interaction,unassigned 1,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21541549&form=6&db=m Expression of the human Bcl-2 increases resistance of Ewing's sarcoma cells to apoptosis and inhibits poly(ADP-ribose) polymerase cleavage induced by radiation. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21594428&form=6&db=m Identification of a rearrangement in the 5' upstream region of the poly(ADP-ribose) polymerase pseudogene on chromosome 13 in Ewing's sarcoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22287547&form=6&db=m PARP-1 inhibition as a targeted strategy to treat Ewing's sarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22460902&form=6&db=m Systematic identification of genomic markers of drug sensitivity in cancer cells. therapeutic application,unassigned 1,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23966622&form=6&db=m Combining poly(ADP-ribose) polymerase 1 (PARP-1) inhibition and radiation in Ewings sarcoma results in lethal DNA damage. unassigned - 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24756371&form=6&db=m New strategies in ewing sarcoma: lost in translation? therapeutic application,unassigned 4,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24840521&form=6&db=m Poly(ADP-ribose) polymerase inhibitors in Ewing sarcoma. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24911143&form=6&db=m Ewing's sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors. ongoing research,unassigned 3,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25374341&form=6&db=m Phase II study of olaparib in patients with refractory Ewing sarcoma following failure of standard chemotherapy. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25500058&form=6&db=m Synergistic Activity of PARP Inhibition by Talazoparib (BMN 673) with Temozolomide in Pediatric Cancer Models in the Pediatric Preclinical Testing Program. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25779942&form=6&db=m SLFN11 Is a Transcriptional Target of EWS-FLI1 and a Determinant of Drug Response in Ewing Sarcoma. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26056084&form=6&db=m The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26438158&form=6&db=m PARP Inhibitors Sensitize Ewing Sarcoma Cells to Temozolomide-Induced Apoptosis via the Mitochondrial Pathway. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26505995&form=6&db=m Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26969300&form=6&db=m Inhibition of SOX2 induces cell apoptosis and G1/S arrest in Ewing's sarcoma through the PI3K/Akt pathway. unassigned - 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27336789&form=6&db=m Registered report: Systematic identification of genomic markers of drug sensitivity in cancer cells. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28672777&form=6&db=m Correction: The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin. therapeutic application,unassigned 3,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28899971&form=6&db=m Matrix screen identifies synergistic combination of PARP inhibitors and nicotinamide phosphoribosyltransferase (NAMPT) inhibitors in Ewing sarcoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29313488&form=6&db=m Replication Study: Systematic identification of genomic markers of drug sensitivity in cancer cells. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29358035&form=6&db=m EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma. therapeutic application,unassigned 2,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29513652&form=6&db=m EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma. therapeutic application,unassigned 3,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29782347&form=6&db=m Current questions in bone sarcomas. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30348635&form=6&db=m The Ewing Family of Tumors Relies on BCL-2 and BCL-XL to Escape PARP Inhibitor Toxicity. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31724813&form=6&db=m Phase 1/2 trial of talazoparib in combination with temozolomide in children and adolescents with refractory/recurrent solid tumors including Ewing sarcoma: A Children's Oncology Group Phase 1 Consortium study (ADVL1411). ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31921673&form=6&db=m Nanoformulation of Talazoparib Increases Maximum Tolerated Doses in Combination With Temozolomide for Treatment of Ewing Sarcoma. therapeutic application,unassigned 4,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31992690&form=6&db=m Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1 promoter. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33006225&form=6&db=m Ewing sarcoma protein promotes dissociation of poly(ADP-ribose) polymerase 1 from chromatin. ongoing research,unassigned 1,0 2.4.2.30 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33289920&form=6&db=m SARC025 arms 1 and 2: A phase 1 study of the poly(ADP-ribose) polymerase inhibitor niraparib with temozolomide or irinotecan in patients with advanced Ewing sarcoma. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Sarcoma, Synovial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27353471&form=6&db=m Synovial sarcoma cell lines showed reduced DNA repair activity and sensitivity to a PARP inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Sarcopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25361036&form=6&db=m Dysregulation of SIRT-1 in aging mice increases skeletal muscle fatigue by a PARP-1-dependent mechanism. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Scabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27002155&form=6&db=m Scabin, a novel DNA-acting ADP-ribosyltransferase from Streptomyces scabies. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Scabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29543870&form=6&db=m Dynamics of Scabin toxin. A proposal for the binding mode of the DNA substrate. unassigned - 2.4.2.30 Scabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33450958&form=6&db=m Mapping the DNA-Binding Motif of Scabin Toxin, a Guanine Modifying Enzyme from Streptomyces scabies. ongoing research,unassigned 1,0 2.4.2.30 Scleroderma, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19376176&form=6&db=m Poly(ADP-ribose) polymerase activity in systemic lupus erythematosis and systemic sclerosis. unassigned - 2.4.2.30 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12083777&form=6&db=m Identification of autoantibodies associated with systemic lupus erythematosus. diagnostic usage,unassigned 3,0 2.4.2.30 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19376176&form=6&db=m Poly(ADP-ribose) polymerase activity in systemic lupus erythematosis and systemic sclerosis. unassigned - 2.4.2.30 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20544540&form=6&db=m PARP activity and NAD concentration in PMC from patients affected by systemic sclerosis and lupus erythematosus. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29431122&form=6&db=m Poly(ADP-ribose) polymerase-1 regulates fibroblast activation in systemic sclerosis. unassigned - 2.4.2.30 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32856128&form=6&db=m Calcinosis in Systemic Sclerosis: Updates in Pathophysiology, Evaluation, and Treatment. unassigned - 2.4.2.30 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1300489&form=6&db=m Evidence for G protein modulation of experimental-generalized absence seizures in rat. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1655474&form=6&db=m Intracerebroventricular pertussis toxin enhances sensitivity to N-methyl-D-aspartate-induced seizures in mice. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1795882&form=6&db=m Suppression of kindled seizure following intraamygdaloid injection of pertussis toxin in rats. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1933276&form=6&db=m Pertussis toxin potentiates seizures induced by pilocarpine, kainic acid and N-methyl-D-aspartate. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8880893&form=6&db=m Intracerebroventricular pertussis toxin enhances sensitivity to chemical convulsants and decreases the protective efficacy of carbamazepine in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 2.4.2.30 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10587085&form=6&db=m Pertussis toxin decreases absence seizures and GABA(B) receptor binding in thalamus of a genetically prone rat (GAERS). ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12097334&form=6&db=m Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases. unassigned - 2.4.2.30 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14678767&form=6&db=m Death mechanisms in status epilepticus-generated neurons and effects of additional seizures on their survival. unassigned - 2.4.2.30 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17632284&form=6&db=m Poly(ADP-ribose) polymerase inhibitor is neuroprotective in epileptic rat via apoptosis-inducing factor and Akt signaling. causal interaction,unassigned 2,0 2.4.2.30 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18417297&form=6&db=m Poly(ADP-ribose) signal in seizures-induced neuron death. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23201256&form=6&db=m Poly(ADP-ribose) polymerase inhibition protects epileptic hippocampal neurons from apoptosis via suppressing Akt-mediated apoptosis-inducing factor translocation in vitro. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25101675&form=6&db=m PARP1 activation/expression modulates regional-specific neuronal and glial responses to seizure in a hemodynamic-independent manner. therapeutic application,unassigned 1,0 2.4.2.30 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26044520&form=6&db=m Regulation of hippocampal Fas receptor and death-inducing signaling complex after kainic acid treatment in mice. unassigned - 2.4.2.30 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33932076&form=6&db=m Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures. causal interaction,unassigned 1,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9302017&form=6&db=m ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury. causal interaction,unassigned 4,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11220641&form=6&db=m The decrease of PKCalpha is associated with hepatic apoptosis at early and late phases of polymicrobial sepsis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11867683&form=6&db=m Distinct fates of monocytes and T cells directly activated by Pseudomonas aeruginosa exoenzyme S. unassigned - 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11943674&form=6&db=m Liposomal NAD(+) prevents diminished O(2) consumption by immunostimulated Caco-2 cells. unassigned - 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11954828&form=6&db=m Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice. causal interaction,ongoing research,unassigned 4,3,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12119470&form=6&db=m Inflammatory cytokines and lipopolysaccharide induce Fas-mediated apoptosis in renal tubular cells. ongoing research,unassigned 3,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12657979&form=6&db=m Role of poly(adenosine diphosphate-ribose) polymerase 1 in septic peritonitis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14752285&form=6&db=m Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026325&form=6&db=m Role of nitrosative stress and activation of poly(ADP-ribose) polymerase-1 in cardiovascular failure associated with septic and hemorrhagic shock. causal interaction,unassigned 4,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16139303&form=6&db=m Pneumonia-induced sepsis and gut injury: effects of a poly-(ADP-ribose) polymerase inhibitor. ongoing research,unassigned 3,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16484919&form=6&db=m Potential role of poly(adenosine 5'-diphosphate-ribose) polymerase activation in the pathogenesis of myocardial contractile dysfunction associated with human septic shock. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16721272&form=6&db=m The parp-1 inhibitor ino-1001 facilitates hemodynamic stabilization without affecting DNA repair in porcine thoracic aortic cross-clamping-induced ischemia/reperfusion. ongoing research,unassigned 1,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16787290&form=6&db=m Redox mechanisms of vascular cell dysfunction in sepsis. therapeutic application,unassigned 2,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16872633&form=6&db=m Local Administration of the Poly ADP-Ribose Polymerase (PARP) Inhibitor, PJ34 During Hindlimb Ischemia Modulates Skeletal Muscle Reperfusion Injury. causal interaction,unassigned 3,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17380790&form=6&db=m Poly (ADP-ribose) polymerase activation and circulatory shock. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25517228&form=6&db=m Poly (ADP-ribose) Polymerase1-Sirtuin1 functional interplay regulates LPS-mediated High Mobility Group Box-1 secretion. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26218895&form=6&db=m Differentiation-Associated Downregulation of Poly(ADP-Ribose) Polymerase-1 Expression in Myoblasts Serves to Increase Their Resistance to Oxidative Stress. causal interaction,unassigned 3,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26221596&form=6&db=m Role of Exogenous Hsp72 on Liver Dysfunction during Sepsis. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26617692&form=6&db=m Poly (ADP-ribose) synthetase inhibitor has a heart protective effect in a rat model of experimental sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29240643&form=6&db=m Temporally Distinct Regulation of Pathways Contributing to Cardiac Proteostasis During the Acute and Recovery Phases of Sepsis. diagnostic usage,unassigned 1,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31071432&form=6&db=m The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological drug for the experimental therapy of sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31877876&form=6&db=m Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32788029&form=6&db=m [Progress of nicotinamide in preventing infection and sepsis]. causal interaction,unassigned 1,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33986609&form=6&db=m PARP Inhibitors: An Innovative Approach to the Treatment of Inflammation and Metabolic Disorders in Sepsis. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34115723&form=6&db=m Repurposing of Clinically Approved Poly-(Adp-Ribose) Polymerase Inhibitors For The Therapy of Sepsis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Sertoli Cell-Only Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16996513&form=6&db=m Role of poly(ADP-ribosyl)ation during human spermatogenesis. diagnostic usage,unassigned 1,0 2.4.2.30 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19109397&form=6&db=m Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Sezary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29205518&form=6&db=m Therapeutic and prognostic significance of PARP-1 in advanced mycosis fungoides and Sezary syndrome. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7847435&form=6&db=m Increase of myocardial inhibitory G-proteins in catecholamine-refractory septic shock or in septic multiorgan failure. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11590148&form=6&db=m The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappa B coactivator function. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11954828&form=6&db=m Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice. causal interaction,ongoing research,unassigned 4,3,0 2.4.2.30 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12440774&form=6&db=m The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders. therapeutic application,unassigned 1,0 2.4.2.30 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12445868&form=6&db=m Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents. causal interaction,unassigned 3,0 2.4.2.30 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12576936&form=6&db=m Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly(ADP-ribose) synthase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.4.2.30 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12694878&form=6&db=m Decrease of the inflammatory response and induction of the Akt/protein kinase B pathway by poly-(ADP-ribose) polymerase 1 inhibitor in endotoxin-induced septic shock. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 2.4.2.30 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14999056&form=6&db=m Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice. ongoing research,unassigned 4,0 2.4.2.30 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15077172&form=6&db=m Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17380790&form=6&db=m Poly (ADP-ribose) polymerase activation and circulatory shock. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 2.4.2.30 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21476963&form=6&db=m Poly (ADP-Ribose) Polymerase-1 (PARP-1) as Immune Regulator. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 2.4.2.30 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25146612&form=6&db=m Association of poly(ADP-ribose) polymerase activity in circulating mononuclear cells with myocardial dysfunction in patients with septic shock. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.4.2.30 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26339143&form=6&db=m The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30280790&form=6&db=m Inhibition of PARP overactivation protects acute kidney injury of septic shock. causal interaction,unassigned 2,0 2.4.2.30 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31071432&form=6&db=m The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological drug for the experimental therapy of sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Shwartzman Phenomenon http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2160028&form=6&db=m Cholera and pertussis exotoxins protect mice against the lethal Schwartzman reaction and antagonize the effects of lipopolysaccharide on second messenger systems. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Silicosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911336&form=6&db=m Poly(ADP-ribosyl)ation in asthma and other lung diseases. causal interaction,unassigned 4,0 2.4.2.30 Sjogren's Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12083777&form=6&db=m Identification of autoantibodies associated with systemic lupus erythematosus. diagnostic usage,unassigned 3,0 2.4.2.30 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7698643&form=6&db=m Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. ongoing research,unassigned 1,0 2.4.2.30 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12102657&form=6&db=m Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28653395&form=6&db=m PARP14 limits severity of allergic skin disease. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21779467&form=6&db=m Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22472897&form=6&db=m PARP-1 protein expression in glioblastoma multiforme. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23175101&form=6&db=m Induction of apoptosis in A431 skin cancer cells by Cissus quadrangularis Linn stem extract by altering Bax-Bcl-2 ratio, release of cytochrome c from mitochondria and PARP cleavage. unassigned - 2.4.2.30 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23807292&form=6&db=m Poly (ADP-ribose) polymerase 1 protein expression in normal and neoplastic prostatic tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.4.2.30 Sleep Apnea, Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27324704&form=6&db=m The relationship between obstructive sleep apnea and intra-epidermal nerve fiber density, PARP activation and foot ulceration in patients with type 2 diabetes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22961666&form=6&db=m Proteomic Profiling Identifies Dysregulated Pathways in Small Cell Lung Cancer and Novel Therapeutic Targets Including PARP1. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22969115&form=6&db=m A genetic snapshot of small cell lung cancer. causal interaction,unassigned 1,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24077350&form=6&db=m Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25400754&form=6&db=m Clinical significance of NQO1 polymorphism and expression of p53, SOD2, PARP1 in limited-stage small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27055253&form=6&db=m Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27440269&form=6&db=m PARP Inhibitor Activity Correlates with SLFN11 Expression and Demonstrates Synergy with Temozolomide in Small Cell Lung Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27871924&form=6&db=m MiR-335 regulates the chemo-radioresistance of small cell lung cancer cells by targeting PARP-1. ongoing research,unassigned 1,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28212573&form=6&db=m Dynamic variations in epithelial-to-mesenchymal transition (EMT), ATM, and SLFN11 govern response to PARP inhibitors and cisplatin in small cell lung cancer. therapeutic application,unassigned 3,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29941481&form=6&db=m The Combination of the PARP Inhibitor Olaparib and the WEE1 Inhibitor AZD1775 as a New Therapeutic Option for Small Cell Lung Cancer. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30327308&form=6&db=m A Phase I Dose-Escalation Study of Veliparib Combined with Carboplatin and Etoposide in Patients with Extensive-Stage Small Cell Lung Cancer and Other Solid Tumors. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30354077&form=6&db=m Nanoemulsion-Based Delivery of Fluorescent PARP Inhibitors in Mouse Models of Small Cell Lung Cancer. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30760478&form=6&db=m PARP Inhibitors: Extending Benefit Beyond BRCA Mutant Cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31215481&form=6&db=m MiR-7-5p-mediated downregulation of PARP1 impacts DNA homologous recombination repair and resistance to doxorubicin in small cell lung cancer. therapeutic application,unassigned 1,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32552309&form=6&db=m Improved radiosynthesis of 123I-MAPi, an auger theranostic agent. ongoing research,unassigned 1,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33069237&form=6&db=m The dual HDAC-PI3K inhibitor CUDC-907 displays single-agent activity and synergizes with PARP inhibitor olaparib in small cell lung cancer. therapeutic application,unassigned 3,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33134168&form=6&db=m The MYC Paralog-PARP1 Axis as a Potential Therapeutic Target in MYC Paralog-Activated Small Cell Lung Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33209463&form=6&db=m PARP inhibitors for small cell lung cancer and their potential for integration into current treatment approaches. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33402194&form=6&db=m Correction to: The dual HDAC-PI3K inhibitor CUDC-907 displays single-agent activity and synergizes with PARP inhibitor olaparib in small cell lung cancer. therapeutic application,unassigned 3,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33493586&form=6&db=m XPO1 inhibition synergizes with PARP1 inhibition in small cell lung cancer by targeting nuclear transport of FOXO3a. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33947690&form=6&db=m Veliparib in Combination with Carboplatin and Etoposide in Patients with Treatment-Naïve Extensive-Stage Small Cell Lung Cancer: A Phase 2 Randomized Study. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34329582&form=6&db=m The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Spermatic Cord Torsion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12686864&form=6&db=m The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.4.2.30 Spermatic Cord Torsion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15072913&form=6&db=m Inhibition of poly(adenosine diphosphate-ribose) polymerase decreases long-term histologic damage in testicular ischemia-reperfusion injury. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Spermatic Cord Torsion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26303136&form=6&db=m The efficiency of Poly(ADP-Ribose) Polymerase (PARP) cleavage on detection of apoptosis in an experimental model of testicular torsion. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3 2.4.2.30 Spinal Cord Compression http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25868101&form=6&db=m Apoptosis in human compressive myelopathy due to metastatic neoplasia. diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12853316&form=6&db=m Poly(ADP-Ribose) polymerase-1 in acute neuronal death and inflammation: a strategy for neuroprotection. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529360&form=6&db=m Poly(ADP-ribosyl)ation enzyme-1 as a target for neuroprotection in acute central nervous system injury. therapeutic application,unassigned 3,0 2.4.2.30 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15452194&form=6&db=m Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15453994&form=6&db=m Poly(ADP-ribose) polymerase activity contributes to peroxynitrite-induced spinal cord neuronal cell death in vitro. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17361386&form=6&db=m The selective poly(ADP)ribose-polymerase 1 inhibitor INO1001 reduces spinal cord injury during porcine aortic cross-clamping-induced ischemia/reperfusion injury. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 2.4.2.30 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18289003&form=6&db=m Role of free radicals and poly(ADP-ribose)polymerase-1 in the development of spinal cord injury: new potential therapeutic targets. therapeutic application,unassigned 4,0 2.4.2.30 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19473058&form=6&db=m Nitric Oxide and Superoxide Anion Differentially Activate Poly(ADP-ribose) Polymerase-1 and Bax to Induce Nuclear Translocation of Apoptosis-Inducing Factor and Mitochondrial Release of Cytochrome c after Spinal Cord Injury. unassigned - 2.4.2.30 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22561282&form=6&db=m Unusual increase in lumbar network excitability of the rat spinal cord evoked by the PARP-1 inhibitor PJ-34 through inhibition of glutamate uptake. therapeutic application,unassigned 1,0 2.4.2.30 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26722405&form=6&db=m 3-aminobenzamide, one of poly(ADP-ribose)polymerase-1 inhibitors, rescuesapoptosisin rat models of spinal cord injury. causal interaction,unassigned 3,0 2.4.2.30 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29255350&form=6&db=m Involvement of poly(ADP-ribose) polymerase-1 in development of spinal cord injury in Chinese individuals: a Chinese clinical study. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32729104&form=6&db=m Role of ABT888, a Novel Poly(ADP-Ribose) Polymerase (PARP) Inhibitor in Countering Autophagy and Apoptotic Processes Associated to Spinal Cord Injury. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11956622&form=6&db=m Poly(ADP-ribose) polymerase turnover alterations do not contribute to PARP overexpression in Ewing's sarcoma cells. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252836&form=6&db=m Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501988&form=6&db=m Abrogation of head and neck squamous cell carcinoma growth by epidermal growth factor receptor ligand fused to pseudomonas exotoxin transforming growth factor alpha-PE38. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18025281&form=6&db=m Histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis through both mitochondrial and Fas (Cd95) signaling in head and neck squamous carcinoma cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21644054&form=6&db=m PARP1 and CASP3 gene expression in a patient with multiple head and neck squamous cell carcinoma and Parkinson disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21837531&form=6&db=m Novel C-Terminal Hsp90 Inhibitor for Head and Neck Squamous Cell Cancer (HNSCC) with in vivo Efficacy and Improved Toxicity Profiles Compared with Standard Agents. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22239178&form=6&db=m Novel targeted therapies in head and neck cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22373581&form=6&db=m Targeted therapy in head and neck cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22627996&form=6&db=m Xanthorrhizol Induces Apoptosis Through ROS-Mediated MAPK Activation in Human Oral Squamous Cell Carcinoma Cells and Inhibits DMBA-Induced Oral Carcinogenesis in Hamsters. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22882088&form=6&db=m Overexpression of chromatin assembly factor-1 p60, poly(ADP-ribose) polymerase 1 and nestin predicts metastasizing behaviour of oral cancer. therapeutic application,unassigned 1,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25324139&form=6&db=m Dual disruption of DNA repair and telomere maintenance for the treatment of head and neck cancer. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25467050&form=6&db=m The inhibition of PARP but not EGFR results in the radiosensitization of HPV/p16-positive HNSCC cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25609062&form=6&db=m Acquisition of relative interstrand crosslinker resistance and PARP inhibitor sensitivity in Fanconi anemia head and neck cancers. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26073085&form=6&db=m Targeting of ?1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26336991&form=6&db=m DNA double strand break repair defect and sensitivity to poly ADP-ribose polymerase (PARP) inhibition in human papillomavirus 16-positive head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26799421&form=6&db=m PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response. causal interaction,unassigned 2,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26808835&form=6&db=m Optical Imaging of PARP1 in Response to Radiation in Oral Squamous Cell Carcinoma. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26927065&form=6&db=m Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27473117&form=6&db=m Sam68 reduces cisplatin-induced apoptosis in tongue carcinoma. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27644669&form=6&db=m Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29416738&form=6&db=m PARP-1 inhibitors sensitize HNSCC cells to APR-246 by inactivation of thioredoxin reductase 1 (TrxR1) and promotion of ROS accumulation. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,1,2 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29719599&form=6&db=m Fanconi anemia and homologous recombination gene variants are associated with functional DNA repair defects in vitro and poor outcome in patients with advanced head and neck squamous cell carcinoma. causal interaction,unassigned 1,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31490091&form=6&db=m Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31575007&form=6&db=m Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma. unassigned - 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31686145&form=6&db=m Autophagy suppression enhances DNA damage and cell death upon treatment with PARP inhibitor Niraparib in laryngeal squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32073931&form=6&db=m Targeting DNA damage response in head and neck cancers through abrogation of cell cycle checkpoints. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32139402&form=6&db=m PARP inhibition enhances radiotherapy of SMAD4 deficient human head and neck squamous cell carcinomas in experimental models. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32401928&form=6&db=m Effect of ethanol extracts of Antrodia cinnamomea on head and neck squamous cell carcinoma cell line. therapeutic application,unassigned 1,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32611474&form=6&db=m The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32936912&form=6&db=m Combined EGFR1 and PARP1 Inhibition Enhances the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Models. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33133138&form=6&db=m Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth. therapeutic application,unassigned 4,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33513474&form=6&db=m A phase I trial adding poly(ADP-ribose) polymerase inhibitor veliparib to induction carboplatin-paclitaxel in patients with head and neck squamous cell carcinoma: Alliance A091101. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33862558&form=6&db=m PARP inhibitors in head and neck cancer: Molecular mechanisms, preclinical and clinical data. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34079088&form=6&db=m Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34206538&form=6&db=m Prevalence of DNA Repair Gene Mutations in Blood and Tumor Tissue and Impact on Prognosis and Treatment in HNSCC. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34354944&form=6&db=m Dual Inhibition of PARP and the Intra-S/G2 Cell Cycle Checkpoints Results in Highly Effective Radiosensitization of HPV-Positive HNSCC Cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6317641&form=6&db=m ADP-ribosylation, DNA repair, cell differentiation and cancer. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9203580&form=6&db=m Nedd5, a mammalian septin, is a novel cytoskeletal component interacting with actin-based structures. unassigned - 2.4.2.30 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16388014&form=6&db=m Cell death induced by serum deprivation in luteal cells involves the intrinsic pathway of apoptosis. unassigned - 2.4.2.30 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17720743&form=6&db=m Heart/Cardiac Muscle: Cocaine- and amphetamine-regulated transcript (CART) peptide as an in vivo regulator of cardiac function in Rana ridibunda frog. therapeutic application,unassigned 1,0 2.4.2.30 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18239155&form=6&db=m PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19500618&form=6&db=m Prothymosin alpha and cell death mode switch, a novel target for the prevention of cerebral ischemia-induced damage. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21613793&form=6&db=m Poly(ADP-Ribose) Polymerase-1 Mediates Angiotensin II-Induced Expression of Plasminogen Activator Inhibitor-1 and Fibronectin in Rat Mesangial Cells. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22525338&form=6&db=m ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23231084&form=6&db=m Hepatitis B virus X gene differentially modulates cell cycle progression and apoptotic protein expression in hepatocyte versus hepatoma cell lines. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23522430&form=6&db=m Cleavage of poly (ADP-ribose) polymerase-1 is involved in the process of porcine ovarian follicular atresia. unassigned - 2.4.2.30 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25271986&form=6&db=m Gemcitabine induces poly (ADP-ribose) polymerase-1 (PARP-1) degradation through autophagy in pancreatic cancer. causal interaction,unassigned 2,0 2.4.2.30 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30323296&form=6&db=m PARP1 promote autophagy in cardiomyocytes via modulating FoxO3a transcription. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30525097&form=6&db=m Cisplatin resistance coupled to enhanced sensitivity to metabolic interventions. therapeutic application,unassigned 1,0 2.4.2.30 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32443613&form=6&db=m A New Pathway Promotes Adaptation of Human Glioblastoma Cells to Glucose Starvation. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33188850&form=6&db=m Signaling interplay between PARP1 and ROS regulates stress-induced cell death and developmental changes in Dictyostelium discoideum. causal interaction,unassigned 4,0 2.4.2.30 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8152537&form=6&db=m Status epilepticus may be caused by loss of adenosine anticonvulsant mechanisms. unassigned - 2.4.2.30 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15944022&form=6&db=m Regulation of limbic status epilepticus by hippocampal galanin type 1 and type 2 receptors. therapeutic application,unassigned 1,0 2.4.2.30 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26388738&form=6&db=m P2X7 receptor-mediated PARP1 activity regulates astroglial death in the rat hippocampus following status epilepticus. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28704930&form=6&db=m Mitochondrial Dysfunction Mediated by Poly(ADP-Ribose) Polymerase-1 Activation Contributes to Hippocampal Neuronal Damage Following Status Epilepticus. unassigned - 2.4.2.30 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31396050&form=6&db=m PKC, AKT and ERK1/2-Mediated Modulations of PARP1, NF-?B and PEA15 Activities Distinctly Regulate Regional Specific Astroglial Responses Following Status Epilepticus. therapeutic application,unassigned 1,0 2.4.2.30 Stomach Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21468218&form=6&db=m Helicobacter pylori activation of PARP-1: Usurping a versatile regulator of host cellular health. therapeutic application,unassigned 4,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10226574&form=6&db=m Extract of Solanum muricatum (Pepino/CSG) inhibits tumor growth by inducing apoptosis. causal interaction,unassigned 1,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10851267&form=6&db=m Adenovirus-mediated E2F-1 gene transfer induces an apoptotic response in human gastric carcinoma cells that is enhanced by cyclin dependent kinase inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16405741&form=6&db=m [Correlation of Genetic Polymorphisms in DNA Repair Genes ADPRT and XRCC1 to Risk of Gastric Cancer.] causal interaction,diagnostic usage,unassigned 3,3,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17007014&form=6&db=m Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells. therapeutic application,unassigned 1,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18716896&form=6&db=m PARP-1 Val762Ala polymorphism, CagA(+) H. pylori infection and risk for gastric cancer in Han Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21612407&form=6&db=m Lymph Node Metastasis of Gastric Cancer Is Associated with the Interaction Between Poly (ADP-Ribose) Polymerase 1 and Matrix Metallopeptidase 2. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21897022&form=6&db=m A novel compound, L34, induced apoptosis in human gastric cancer cells. causal interaction,unassigned 1,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22221038&form=6&db=m PARP1 Polymorphisms Increase the Risk of Gastric Cancer in a Chinese Population. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22337872&form=6&db=m CHFR regulates the mitotic checkpoint by targeting PARP-1 for ubiquitination and degradation. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22431000&form=6&db=m miR-106a Is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS. therapeutic application,unassigned 3,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22901183&form=6&db=m ADPRT Val762Ala and XRCC1 Arg194Trp Polymorphisms and Risk of Gastric Cancer in Sichuan of China. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23020228&form=6&db=m Cochinchina momordica seed extract induces apoptosis and cell cycle arrest in human gastric cancer cells via PARP and p53 signal pathways. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23298900&form=6&db=m Tumor-suppressive effects of 1,25-dihydroxyvitamin D3 in gastric cancer cells. therapeutic application,unassigned 2,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23317230&form=6&db=m Polymorphisms of XRCC1 and ADPRT genes and risk of noncardia gastric cancer in a Chinese population: a case-control study. therapeutic application,unassigned 1,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23522835&form=6&db=m In silico identification of poly(ADP-ribose)polymerase-1 inhibitors and their chemosensitizing effects against cisplatin-resistant human gastric cancer cells. ongoing research,unassigned 2,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24395528&form=6&db=m Ultrafine particles of Ulmus davidiana var. japonica induce apoptosis of gastric cancer cells via activation of caspase and endoplasmic reticulum stress. ongoing research,unassigned 4,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24841718&form=6&db=m Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25485492&form=6&db=m PARP inhibitors target ATM+p53-defective gastric cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25638174&form=6&db=m Luteolin exerts a marked antitumor effect in cMet-overexpressing patient-derived tumor xenograft models of gastric cancer. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26101707&form=6&db=m Metformin inhibits gastric cancer via the inhibition of HIF1?/PKM2 signaling. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26282638&form=6&db=m Complexity in the Gastric Cancer Genome and a Biomarker-Driven Trial of Poly (ADP-Ribose) Polymerase Inhibition in Gastric Cancer. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26282658&form=6&db=m Randomized, Double-Blind Phase II Trial With Prospective Classification by ATM Protein Level to Evaluate the Efficacy and Tolerability of Olaparib Plus Paclitaxel in Patients With Recurrent or Metastatic Gastric Cancer. ongoing research,unassigned 2,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26388407&form=6&db=m Esculetin induces apoptosis in human gastric cancer cells through a cyclophilin D-mediated mitochondrial permeability transition pore associated with ROS. unassigned - 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26511885&form=6&db=m A mutational signature in gastric cancer suggests therapeutic strategies. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26540566&form=6&db=m Tumor suppressive effect of PARP1 and FOXO3A in gastric cancers and its clinical implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27175747&form=6&db=m Lentivirus-mediated inhibition of USP39 suppresses the growth of gastric cancer cells via PARP activation. causal interaction,unassigned 2,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27638859&form=6&db=m ATM expression predicts Veliparib and Irinotecan sensitivity in gastric cancer by mediating P53 independent regulation of cell cycle and apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,1 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27895737&form=6&db=m High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28000850&form=6&db=m Fas expression is downregulated in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28401005&form=6&db=m Chk1 inhibition potentiates the therapeutic efficacy of PARP inhibitor BMN673 in gastric cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28827033&form=6&db=m Inhibition of PARP1 activity enhances chemotherapeutic efficiency in cisplatin-resistant gastric cancer cells. therapeutic application,unassigned 2,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29036264&form=6&db=m Immature colon carcinoma transcript-1 promotes proliferation of gastric cancer cells. unassigned - 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29293500&form=6&db=m PARP10 (ARTD10) modulates mitochondrial function. causal interaction,unassigned 1,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29305976&form=6&db=m Functional long non-coding RNAs associated with gastric cancer susceptibility and evaluation of the epidemiological efficacy in a central Chinese population. unassigned - 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29393362&form=6&db=m Tanshinone IIA inhibits gastric carcinoma AGS cells by decreasing the protein expression of VEGFR and blocking Ras/Raf/MEK/ERK pathway. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29402413&form=6&db=m Inhibition of CREPT restrains gastric cancer growth by regulation of cycle arrest, migration and apoptosis via ROS-regulated p53 pathway. therapeutic application,unassigned 1,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29511458&form=6&db=m SOX2 inhibits cell proliferation and metastasis, promotes apoptotic by downregulating CCND1 and PARP in gastric cancer. ongoing research,unassigned 3,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29767248&form=6&db=m Combined treatment with PI3K inhibitor BKM120 and PARP inhibitor olaparib is effective in inhibiting the gastric cancer cells with ARID1A deficiency. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29786670&form=6&db=m Deubiquitinylase USP47 Promotes RelA Phosphorylation and Survival in Gastric Cancer Cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30231398&form=6&db=m What Will We Expect From Novel Therapies to Esophageal and Gastric Malignancies? causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30323630&form=6&db=m Knockdown of RNF6 inhibits gastric cancer cell growth by suppressing STAT3 signaling. causal interaction,unassigned 3,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30635820&form=6&db=m LncRNA ZEB2-AS1 contributes to the tumorigenesis of gastric cancer via activating the Wnt/?-catenin pathway. diagnostic usage,unassigned 1,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31114162&form=6&db=m The molecular mechanisms of Aloin induce gastric cancer cells apoptosis by targeting High Mobility Group Box 1. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31174925&form=6&db=m PARP1: A potential biomarker for gastric cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,4,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31774011&form=6&db=m Allele-specific expression mediates primary resistance to poly (ADP-ribose) polymerase inhibitor therapy in a case of BRCA1/2 double-germline mutant gastric cancer. therapeutic application,unassigned 4,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31812083&form=6&db=m Silencing of CHFR Sensitizes Gastric Carcinoma to PARP Inhibitor Treatment. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31983162&form=6&db=m Association between PSCA, TNF-?, PARP1 and TP53 Gene Polymorphisms and Gastric Cancer Susceptibility in the Brazilian Population. unassigned - 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32106377&form=6&db=m Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS. causal interaction,diagnostic usage,unassigned 3,1,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32686903&form=6&db=m Inhibition of c-MET increases the antitumour activity of PARP inhibitors in gastric cancer models. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33388624&form=6&db=m Combination of talaporfin photodynamic therapy and Poly (ADP-Ribose) polymerase (PARP) inhibitor in gastric cancer. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33464437&form=6&db=m Variant of SNPs at lncRNA NEAT1 contributes to gastric cancer susceptibility in Chinese Han population. diagnostic usage,unassigned 1,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34167572&form=6&db=m PARP inhibitors in gastric cancer: beacon of hope. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34280886&form=6&db=m MTA2 sensitizes gastric cancer cells to PARP inhibition by induction of DNA replication stress. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34491229&form=6&db=m Identification and epidemiological evaluation of gastric cancer risk factors: based on a field synopsis and meta-analysis in Chinese population. unassigned - 2.4.2.30 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22257724&form=6&db=m The use of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation during prevention of gastric inflammation induced by ethanol in rat. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9390645&form=6&db=m Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10322503&form=6&db=m Poly (ADP-ribose) polymerase, nitric oxide and cell death. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10657571&form=6&db=m Evaluation of the poly(ADP-ribose) polymerase gene in human stroke. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10771174&form=6&db=m The neuroprotective effect of cerebral poly(ADP-ribose)polymerase inhibition in a rat model of global ischemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10964595&form=6&db=m Poly(ADP-ribose) polymerase-1 in the nervous system. causal interaction,unassigned 1,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179503&form=6&db=m Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11376691&form=6&db=m Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11590148&form=6&db=m The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappa B coactivator function. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11766996&form=6&db=m Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11846617&form=6&db=m Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors. causal interaction,unassigned 3,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11935067&form=6&db=m Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12213537&form=6&db=m Nicotinamide therapy protects against both necrosis and apoptosis in a stroke model. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12225730&form=6&db=m Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12570705&form=6&db=m Poly(ADP-ribose) polymerase inhibitors. causal interaction,unassigned 4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12628304&form=6&db=m Development of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14512702&form=6&db=m Nicotinamide offers multiple protective mechanisms in stroke as a precursor for NAD+, as a PARP inhibitor and by partial restoration of mitochondrial function. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14767566&form=6&db=m Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075382&form=6&db=m A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15077172&form=6&db=m Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15452194&form=6&db=m Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466246&form=6&db=m A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15561303&form=6&db=m Poly(ADP-ribose) polymerases: homology, structural domains and functions. Novel therapeutical applications. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15857303&form=6&db=m Poly (adp-ribose) polymerase inhibitors as potential therapeutic agents in stroke and neurotrauma. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15864271&form=6&db=m Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911329&form=6&db=m Mediation of cell death by poly(ADP-ribose) polymerase-1. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911339&form=6&db=m Clinical perspectives of PARP inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026317&form=6&db=m Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies. causal interaction,unassigned 3,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026326&form=6&db=m Pharmacological inhibition of poly(ADP-ribose) polymerase in cardiovascular disorders: future directions. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16181138&form=6&db=m Poly(ADP-ribose)polymerase inhibition - where now? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16357945&form=6&db=m Development of a miniaturized assay for the high-throughput screening program for poly(ADP-ribose) polymerase-1. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16872633&form=6&db=m Local Administration of the Poly ADP-Ribose Polymerase (PARP) Inhibitor, PJ34 During Hindlimb Ischemia Modulates Skeletal Muscle Reperfusion Injury. causal interaction,unassigned 3,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17055069&form=6&db=m Novel modulators of poly(ADP-ribose) polymerase. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17222914&form=6&db=m Molecular targets in cerebral ischemia for developing novel therapeutics. causal interaction,unassigned 1,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17430191&form=6&db=m Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17520094&form=6&db=m Poly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18032109&form=6&db=m Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage. therapeutic application,unassigned 3,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18091544&form=6&db=m Poly(ADP-ribose) polymerase-1 inhibition increases expression of heat shock proteins and attenuates heat stroke-induced liver injury. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18207135&form=6&db=m Combinatorial-approached neuroprotection using pan-caspase inhibitor and poly (ADP-ribose) polymerase (PARP) inhibitor following experimental stroke in rats; is there additional benefit? therapeutic application,unassigned 4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18468597&form=6&db=m Reduction of hemorrhagic transformation by PJ34, a poly(ADP-ribose)polymerase inhibitor, after permanent focal cerebral ischemia in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19087198&form=6&db=m Post-ischemic brain damage: targeting PARP-1 within the ischemic neurovascular units as a realistic avenue to stroke treatment. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19190653&form=6&db=m Inhibition of poly(ADP-ribose) polymerase suppresses inflammation and promotes recovery after ischemic injury. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19190654&form=6&db=m Sex differences in minocycline-induced neuroprotection after experimental stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19268668&form=6&db=m Sex differences in the response to activation of the poly (ADP-ribose) polymerase pathway after experimental stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19273119&form=6&db=m Parthanatos, a messenger of death. unassigned - 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19362586&form=6&db=m PARP inhibitors: New partners in the therapy of cancer and inflammatory diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19529948&form=6&db=m Neuronal caspase-3 and PARP-1 correlate differentially with apoptosis and necrosis in ischemic human stroke. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20633699&form=6&db=m Poly(ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications. causal interaction,unassigned 3,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20825413&form=6&db=m Role of Cytotoxic Protease Granzyme-b in Neuronal Degeneration during Human Stroke. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21311064&form=6&db=m Sex Differences in the Response to Poly(ADP-ribose) Polymerase-1 Deletion and Caspase Inhibition After Stroke. therapeutic application,unassigned 3,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21409386&form=6&db=m Anti-inflammatory mechanism of taurine against ischemic stroke is related to down-regulation of PARP and NF-?B. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21476963&form=6&db=m Poly (ADP-Ribose) Polymerase-1 (PARP-1) as Immune Regulator. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21602803&form=6&db=m Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death. unassigned - 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21913897&form=6&db=m Long-lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP-ribose) polymerase. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22476980&form=6&db=m Natural Inhibitors of Poly(ADP-ribose) Polymerase-1. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23370117&form=6&db=m Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23876515&form=6&db=m Prevention of rt-PA induced blood-brain barrier component degradation by the poly(ADP-ribose)polymerase inhibitor PJ34 after ischemic stroke in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24323707&form=6&db=m Mitochondrial dysfunction induced by nuclear poly(ADP-ribose) polymerase-1: a treatable cause of cell death in stroke. causal interaction,unassigned 1,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25062913&form=6&db=m Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25262797&form=6&db=m A review on PARP1 inhibitors: Pharmacophore modeling, virtual and biological screening studies to identify novel PARP1 inhibitors. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25882840&form=6&db=m Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25924998&form=6&db=m Poly(ADP-Ribose)Polymerase 1 (PARP-1) Activation and Ca(2+) Permeable ?-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Channels in Post-Ischemic Brain Damage: New Therapeutic Opportunities? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26339143&form=6&db=m The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26709902&form=6&db=m Alternative mechanisms of inhibiting activity of poly (ADP-ribose) polymerase-1. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28108258&form=6&db=m Downregulation of Iduna is associated with AIF nuclear translocation in neonatal brain after hypoxia-ischemia. unassigned - 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28674991&form=6&db=m Cell Death Mechanisms of Neurodegeneration. causal interaction,unassigned 1,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29383691&form=6&db=m Early Treatment with Poly(ADP-Ribose) Polymerase-1 Inhibitor (JPI-289) Reduces Infarct Volume and Improves Long-Term Behavior in an Animal Model of Ischemic Stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29709770&form=6&db=m Regulatory T cells increase after treatment with poly (ADP-ribose) polymerase-1 inhibitor in ischemic stroke patients. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29852289&form=6&db=m Sex differences in the effects of PARP inhibition on microglial phenotypes following neonatal stroke. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29968072&form=6&db=m Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30260276&form=6&db=m Polymorphism of PARP-1 indicates an increased risk and a worse initial severity of ischemic stroke. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30567936&form=6&db=m Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31683401&form=6&db=m [Gender-specific factors of ischemic stroke among atrial fibrillation patients]. unassigned - 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32317937&form=6&db=m Delayed PARP-1 Inhibition Alleviates Post-stroke Inflammation in Male Versus Female Mice: Differences and Similarities. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32676579&form=6&db=m Muscle-specific sirtuin1 gain-of-function ameliorates skeletal muscle atrophy in a pre-clinical mouse model of cerebral ischemic stroke. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33317392&form=6&db=m PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33387580&form=6&db=m Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34025565&form=6&db=m Targeting Parthanatos in Ischemic Stroke. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34200155&form=6&db=m Poly(ADP-Ribose) Polymerase Inhibitor PJ34 Reduces Brain Damage after Stroke in the Neonatal Mouse Brain. therapeutic application,unassigned 1,0 2.4.2.30 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34241907&form=6&db=m Emerging role of PARP-1 and PARthanatos in ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Strongyloidiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28178298&form=6&db=m The impact of prenatal exposure to parasitic infections and to anthelminthic treatment on antibody responses to routine immunisations given in infancy: Secondary analysis of a randomised controlled trial. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11136941&form=6&db=m Inhibition of poly(ADP-ribose) polymerase attenuates cerebral vasospasm after subarachnoid hemorrhage in rabbits. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27157545&form=6&db=m PARP inhibition attenuates early brain injury through NF-?B/MMP-9 pathway in a rat model of subarachnoid hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 2.4.2.30 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30680005&form=6&db=m Potential role of poly (ADP-ribose) polymerase in delayed cerebral vasospasm following subarachnoid hemorrhage in rats. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Sunburn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12102657&form=6&db=m Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 superoxide dismutase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19395552&form=6&db=m Role of Oxidative Stress and AT1 Receptors in Cerebral Vascular Dysfunction with Aging. causal interaction,unassigned 4,0 2.4.2.30 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29922443&form=6&db=m Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Tachycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3736338&form=6&db=m Effect of pertussis toxin on the heart muscarinic-cholinergic receptors and their function. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 2.4.2.30 Tachycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6319845&form=6&db=m "Pertussis toxin induces tachycardia and impairs the increase in blood pressure produced by alpha 2-adrenergic agonists". unassigned - 2.4.2.30 Tachycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8385589&form=6&db=m The effects of pertussis toxin on vasoconstrictor and vasodilator agents in the pithed rat may not be an indicator of G-protein receptor coupling. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23238565&form=6&db=m Loss of PIDD limits NF-?B activation and cytokine production but not cell survival or transformation after DNA damage. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23328638&form=6&db=m Concordance of ATM (Ataxia Telangiectasia Mutated) Immunohistochemistry between Biopsy or Metastatic Tumor Samples and Primary Tumors in Gastric Cancer Patients. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27572101&form=6&db=m Casticin induces DNA damage and inhibits DNA repair-associated protein expression in B16F10 mouse melanoma cancer cells. unassigned - 2.4.2.30 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34027408&form=6&db=m Targeting IDH1/2 mutant cancers with combinations of ATR and PARP inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Teratocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10557323&form=6&db=m Syncytiotrophoblastic giant cells in teratocarcinoma-like tumors derived from Parp-disrupted mouse embryonic stem cells. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Teratocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11988329&form=6&db=m Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in the placenta. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Teratocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23957916&form=6&db=m Parp-1 deficiency in ES cells promotes invasive and metastatic lesions accompanying induction of trophoblast giant cells during tumorigenesis in uterine environment. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Teratoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23486608&form=6&db=m PARP expression in germ cell tumours. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.4.2.30 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25673562&form=6&db=m Spermatid Head Elongation with Normal Nuclear Shaping Requires ADP-Ribosyltransferase PARP11 (ARTD11) in Mice. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Testicular Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23486608&form=6&db=m PARP expression in germ cell tumours. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1346876&form=6&db=m Immunogenicity of combined diphtheria, tetanus, and pertussis vaccine given at 2, 3, and 4 months versus 3, 5, and 9 months of age. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1621656&form=6&db=m Clinical reactions and immunogenicity of the BIKEN acellular diphtheria and tetanus toxoids and pertussis vaccine in 4- through 6-year-old US children. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1681018&form=6&db=m Immunogenicity of primary DPT vaccination. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,3,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1855015&form=6&db=m Persistence of antibody after accelerated immunisation with diphtheria/tetanus/pertussis vaccine. therapeutic application,unassigned 1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2254024&form=6&db=m Production of tumor necrosis factors alpha and beta by human mononuclear leukocytes stimulated with mitogens, bacteria, and malarial parasites. unassigned - 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2265696&form=6&db=m The inhibition by pertussis and tetanus toxins of evoked catecholamine release from intact and permeabilized bovine adrenal chromaffin cells. ongoing research,unassigned 4,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2461309&form=6&db=m Regulatory factors that determine growth and phenotype of normal human melanocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7507893&form=6&db=m Neutralizing antibodies and immunoprotection against pertussis and tetanus obtained by use of a recombinant pertussis toxin-tetanus toxin fusion protein. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7521636&form=6&db=m A randomized controlled trial of two acellular pertussis-diphtheria-tetanus vaccines in primary immunization in Ghana: antibody responses and adverse reactions. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7636648&form=6&db=m Effect of priming with diphtheria and tetanus toxoids combined with whole-cell pertussis vaccine or with acellular pertussis vaccine on the safety and immunogenicity of a booster dose of an acellular pertussis vaccine containing a genetically inactivated pertussis toxin in fifteen- to twenty-one-month-old children. Italian Multicenter Group for the Study of Recombinant Acellular Pertussis Vaccine. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7659475&form=6&db=m Comparison of 13 acellular pertussis vaccines: overview and serologic response. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7768587&form=6&db=m A mutant pertussis toxin molecule that lacks ADP-ribosyltransferase activity, PT-9K/129G, is an effective mucosal adjuvant for intranasally delivered proteins. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8201477&form=6&db=m Comparative study of a whole-cell pertussis vaccine and a recombinant acellular pertussis vaccine. The Italian Multicenter Group for the Study of Recombinant Acellular Pertussis Vaccine. diagnostic usage,therapeutic application,unassigned 4,2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8406812&form=6&db=m Pertussis toxin-induced alterations of murine hepatic drug metabolism following administration of diphtheria and tetanus toxoids and pertussis vaccine adsorbed. diagnostic usage,therapeutic application,unassigned 2,2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8438810&form=6&db=m Comparison of the safety and immunogenicity of acellular (BIKEN) and whole-cell pertussis vaccines in 15- to 20-month-old children. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8522378&form=6&db=m Serum antibodies to the components of diphtheria-tetanus-pertussis vaccine in Polish children related to vaccination status. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8533580&form=6&db=m Immunogenicity and reactogenicity of the component acellular pertussis vaccine produced by a combination of column purified pertussis toxin and filamentous haemagglutinin. unassigned - 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8744555&form=6&db=m Pertussis toxin enhanced IgG1 and IgE responses to primary tetanus immunization are mediated by interleukin-4 and persist during secondary responses to tetanus alone. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8785949&form=6&db=m Validation of the toxin-binding inhibition (ToBI) test for the estimation of the potency of the tetanus toxoïd component in vaccines. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9031875&form=6&db=m Comparative safety and immunogenicity of an acellular versus whole-cell pertussis component of diphtheria-tetanus-pertussis vaccines in Senegalese infants. unassigned - 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9272340&form=6&db=m Adverse reactions of a pertussis toxoid vaccine in a double-blind placebo-controlled trial. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9273995&form=6&db=m Quartz crystal microbalance investigation of the interaction of bacterial toxins with ganglioside containing solid supported membranes. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9427051&form=6&db=m Serum antibodies to diphtheria-tetanus-pertussis vaccine components in Argentine children. diagnostic usage,therapeutic application,unassigned 4,3,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9427455&form=6&db=m Safety and immunogenicity of a combined pentavalent diphtheria, tetanus, acellular pertussis, inactivated poliovirus and Haemophilus influenzae type b-tetanus conjugate vaccine in infants, compared with a whole cell pertussis pentavalent vaccine. causal interaction,unassigned 2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9569476&form=6&db=m Effect of combination with an acellular pertussis, diphtheria, tetanus vaccine on antibody response to Hib vaccine (PRP-T). therapeutic application,unassigned 1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10206134&form=6&db=m Adverse effects and sero-responses to an acellular pertussis/diphtheria/tetanus vaccine when combined with Haemophilus influenzae type b vaccine in an accelerated schedule. diagnostic usage,ongoing research,unassigned 4,2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10493336&form=6&db=m Comparison of a fifth dose of a five-component acellular or a whole cell pertussis vaccine in children four to six years of age. therapeutic application,unassigned 1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10496883&form=6&db=m Humoral and cellular immune responses in mice immunized with recombinant Mycobacterium bovis Bacillus Calmette-Guérin producing a pertussis toxin-tetanus toxin hybrid protein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10580209&form=6&db=m Immunogenicity study of a combined diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis vaccine used to reconstitute a freeze-dried Haemophilus influenzae type b vaccine (DTaP-IPV//PRP-T) administered simultaneously with a hepatitis B vaccine at two, three and four months of life. diagnostic usage,therapeutic application,unassigned 2,2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10592076&form=6&db=m Local reactions and IgE antibodies to pertussis toxin after acellular diphtheria-tetanus-pertussis immunization. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600208&form=6&db=m Evaluation of a guinea pig model to assess interference in the immunogenicity of different components of a combination vaccine comprising diphtheria, tetanus and acellular pertussis (DTaP) vaccine and haemophilus influenzae type b capsular polysaccharide conjugate vaccine. therapeutic application,unassigned 1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10617148&form=6&db=m Entrapping of impermeant probes of different size into nonpermeabilized synaptosomes as a method to study presynaptic mechanisms. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10617748&form=6&db=m Safety and immunogenicity of six acellular pertussis vaccines and one whole-cell pertussis vaccine given as a fifth dose in four- to six-year-old children. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10617749&form=6&db=m Extensive swelling after booster doses of acellular pertussis-tetanus-diphtheria vaccines. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10624095&form=6&db=m [Induction of protective immunity for Bordetella pertussis by nasal inoculation of pertussis vaccine in mice] ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10825586&form=6&db=m Specific T cell deletion by transfected human monocytes expressing fas ligand and antigen. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10910608&form=6&db=m Effect of local massage on vaccination: DTP and DTPa. therapeutic application,unassigned 2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11312009&form=6&db=m Immunogenicity and reactogenicity of a single dose of a diphtheria--tetanus--acellular pertussis component vaccine (DTaP) compared to a diphtheria--tetanus toxoid (Td) and a diphtheria toxoid vaccine (d) in adults. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,2 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11520252&form=6&db=m Antibody responses of healthy infants to concurrent administration of a bivalent haemophilus influenzae type b-hepatitis B vaccine with diphtheria-tetanus-pertussis, polio and measles-mumps-rubella vaccines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11870619&form=6&db=m Generation of adult-like antibody avidity profiles after early-life immunization with protein vaccines. ongoing research,unassigned 2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12403070&form=6&db=m On technological and immunological benefits of multivalent single-injection microsphere vaccines. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12911336&form=6&db=m The use of microcalorimetry to characterize tetanus neurotoxin, pertussis toxin and filamentous haemagglutinin. unassigned - 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14532091&form=6&db=m Identification of peptides that mimic the pertussis toxin binding site on bovine fetuin. causal interaction,unassigned 3,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14711858&form=6&db=m Acellular pertussis vaccine given by accelerated schedule: response of preterm infants. diagnostic usage,unassigned 1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15060220&form=6&db=m Antibody response to diphtheria-tetanus-pertussis immunization in preterm infants who receive dexamethasone for chronic lung disease. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16249929&form=6&db=m Diphtheria, tetanus and pertussis antibodies in 10-year-old children before and after a booster dose of three toxoids: implications for the timing of a booster dose. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16410887&form=6&db=m Immunogenicity of a combined DTPa-HB vaccine co-administered with Haemophilus influenzae type B conjugate vaccine (PRP-T) for primary and booster vaccinations. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16950635&form=6&db=m Expression and purification of a trivalent pertussis toxin-diphtheria toxin-tetanus toxin fusion protein in Escherichia coli. unassigned - 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18321880&form=6&db=m Measuring immunoglobulin g antibodies to tetanus toxin, diphtheria toxin, and pertussis toxin with single-antigen enzyme-linked immunosorbent assays and a bead-based multiplex assay. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18407287&form=6&db=m Development and validation of a multiplex immunoassay for the simultaneous determination of serum antibodies to Bordetella pertussis, diphtheria and tetanus. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18782261&form=6&db=m Effect of HLA genotype or CTLA-4 polymorphism on cytokine response in healthy children. ongoing research,unassigned 4,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19464556&form=6&db=m Generation of plant-derived recombinant DTP subunit vaccine. ongoing research,unassigned 2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19480581&form=6&db=m Seroprevalence and placental transportation of maternal antibodies specific for Neisseria meningitidis serogroup C, Haemophilus influenzae type B, diphtheria, tetanus, and pertussis. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20864810&form=6&db=m Humoral immunity of dTap-IPV vaccine (REPEVAX(®)) administered one month after dT-IPV vaccine (REVAXIS(®)) in adults with unknown vaccination history. therapeutic application,unassigned 2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21043546&form=6&db=m Tdap(5) vaccine (covaxis®): a review of its use as a single-booster immunization for the prevention of tetanus, diphtheria, and pertussis in children (aged ?4 years), adolescents, and adults. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21187178&form=6&db=m Identifying long-term memory B-cells in vaccinated children despite waning antibody levels specific for Bordetella pertussis proteins. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21325488&form=6&db=m Fast, antigen-saving multiplex immunoassay to determine levels and avidity of mouse serum antibodies to pertussis, diphtheria, and tetanus antigens. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21351814&form=6&db=m Spotlight on Tdap? vaccine (Covaxis®) as a single-booster immunization for the prevention of tetanus, diphtheria, and pertussis: in children (aged ?4 years), adolescents, and adults. therapeutic application,unassigned 1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22863658&form=6&db=m A fully liquid DTaP-IPV-Hep B-PRP-T hexavalent vaccine for primary and booster vaccination of healthy Mexican children. therapeutic application,unassigned 1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23994021&form=6&db=m Experience with monocomponent acellular pertussis combination vaccines for infants, children, adolescents and adults-A review of safety, immunogenicity, efficacy and effectiveness studies and 15 years of field experience. diagnostic usage,therapeutic application,unassigned 2,4,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24108779&form=6&db=m Immunogenicity and safety after booster vaccination of diphtheria, tetanus, and acellular pertussis in young adults: an open randomized controlled trial in Japan. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25510388&form=6&db=m Interchangeability of meningococcal group C conjugate vaccines with different carrier proteins in the United Kingdom infant immunisation schedule. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26529073&form=6&db=m Pertussis vaccination during pregnancy in Vietnam: Results of a randomized controlled trial Pertussis vaccination during pregnancy. diagnostic usage,therapeutic application,unassigned 1,2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26592142&form=6&db=m Pertussis vaccination during pregnancy in Belgium: Results of a prospective controlled cohort study. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27142328&form=6&db=m Pertussis vaccination during pregnancy in Belgium: Follow-up of infants until 1 month after the fourth infant pertussis vaccination at 15 months of age. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27171114&form=6&db=m A Belgian Serosurveillance/Seroprevalence Study of Diphtheria, Tetanus and Pertussis Using a Luminex xMAP Technology-Based Pentaplex. therapeutic application,unassigned 2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27838673&form=6&db=m The Effect of Maternal Pertussis Immunization on Infant Vaccine Responses to a Booster Pertussis-Containing Vaccine in Vietnam. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28233625&form=6&db=m Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28277900&form=6&db=m Influence of maternal vaccination against diphtheria, tetanus, and pertussis on the avidity of infant antibody responses to a pertussis containing vaccine in Belgium. diagnostic usage,therapeutic application,unassigned 1,3,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087050&form=6&db=m Immune response to a Tdap booster in vertically HIV-infected adolescents. diagnostic usage,unassigned 4,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30136189&form=6&db=m Optimization of rPDT fusion protein expression by Escherichia coli in pilot scale fermentation: a statistical experimental design approach. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30208475&form=6&db=m Immunogenicity and Safety of Monovalent Acellular Pertussis Vaccine at Birth: A Randomized Clinical Trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,2 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30212033&form=6&db=m [Seroepidemiological Studies on Pertussis, Diphtheria and Tetanus among Nursing Students Enrolled between 1994 and 2011 in the Kitakyushu District]. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30219367&form=6&db=m Reactogenicity and immunogenicity of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant and nonpregnant women. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30690077&form=6&db=m Development and Validation of Magnetic Bead Pentaplex Immunoassay for Simultaneous Quantification of murine serum IgG antibodies to Acellular Pertussis, Diphtheria and Tetanus Antigens used in combination vaccines. therapeutic application,unassigned 1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30758857&form=6&db=m Antibody responses to Bordetella pertussis and other childhood vaccines in infants born to mothers who received pertussis vaccine in pregnancy- a prospective, observational cohort study from the UK. ongoing research,unassigned 2,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30831450&form=6&db=m Quantitative determination of bioactive proteins in diphtheria tetanus acellular pertussis (DTaP) vaccine by liquid chromatography tandem mass spectrometry. diagnostic usage,unassigned 1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32067048&form=6&db=m Waning vaccine immunity and vaccination responses in children treated for acute lymphoblastic leukemia: A Canadian Immunization Research Network Study. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32387447&form=6&db=m Seroprevalence of antibodies against diphtheria, tetanus, and pertussis among healthy Thai adolescents. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32930758&form=6&db=m Association of Routine Infant Vaccinations With Antibody Levels Among Preterm Infants. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33059000&form=6&db=m The quantitative analysis of the mechanism involved in pertussis toxin-mediated cell clustering and its implications in the in vitro quality control of diphtheria tetanus and whole cell pertussis vaccines. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33176935&form=6&db=m Enhanced post-licensure safety surveillance of a new recombinant acellular pertussis vaccine licensed as a monovalent (aP, Pertagen®) and tetanus, reduced-dose diphtheria combination (TdaP, Boostagen®) vaccine for immunization of adolescents and adults in Thailand. therapeutic application,unassigned 3,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33197362&form=6&db=m Adequate tetanus but poor diphtheria and pertussis response to a Tdap booster in adolescents with juvenile systemic lupus erythematosus. diagnostic usage,unassigned 4,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33478788&form=6&db=m Tdap booster to adolescents with juvenile idiopathic arthritis on and off anti-TNF agents is safe and immunogenic. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33517831&form=6&db=m Decline of serologic immunity to diphtheria, tetanus and pertussis with age suggested a full life vaccination in mainland China. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34386749&form=6&db=m Antibody persistence 2 and 3 years after booster vaccination of adolescents with recombinant acellular pertussis monovalent aPgen or combined TdaPgen vaccines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8448592&form=6&db=m Pharmacological differentiation by pertussis toxin of the in vivo acute responses to fMLP and PAF in guinea-pig lungs. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29075104&form=6&db=m Risk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: a meta-analysis of randomized controlled trials. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30466807&form=6&db=m Identifying the need to refine the potential patient risk factors for niraparib-induced thrombocytopenia. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33191394&form=6&db=m Avatrombopag Optimizes Response to Niraparib by Managing Thrombocytopenia Associated with Poly-ADP Ribose Polymerase (PARP) Inhibition in Ovarian Cancer and Breast Cancer: A Case Series. causal interaction,unassigned 4,0 2.4.2.30 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33254040&form=6&db=m Efficacy and safety of PARP inhibitors in the treatment of advanced ovarian cancer: An updated systematic review and meta-analysis of randomized controlled trials. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33421183&form=6&db=m Haematologic toxicities with PARP inhibitors in cancer patients: an up-to-date meta-analysis of 29 randomized controlled trials. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33784822&form=6&db=m PARP inhibitor treatment of advanced breast cancer beyond the BRCA-mutated type: a meta-analysis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9515109&form=6&db=m [Endothelial dysfunction and atherosclerosis] unassigned - 2.4.2.30 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7602094&form=6&db=m IL-1 stimulates a diverging signaling pathway in EL4 6.1 thymoma cells. IL-2 release, but not IL-2 receptor expression, is sensitive to pertussis toxin. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8674763&form=6&db=m Effect of pertussis toxin and PGE2 on the functioning of the IL-2 promoter in interleukin-1 treated EL4.NOB-1 thymoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30116283&form=6&db=m Advances in the use of PARP inhibitor therapy for breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31676714&form=6&db=m Metastatic Thymoma Harboring a Deleterious BRCA2 Mutation Derives Durable Clinical Benefit from Olaparib. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32297440&form=6&db=m Metastatic Thymoma Harboring a Deleterious BRCA2 Mutation Derives Durable Clinical Benefit from Olaparib. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28086241&form=6&db=m LncRNA-SLC6A9-5:2: A potent sensitizer in 131I-resistant papillary thyroid carcinoma with PARP-1 induction. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.4.2.30 Thyroid Carcinoma, Anaplastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25139258&form=6&db=m PARP inhibitor olaparib increases the oncolytic activity of dl922-947 in in vitro and in vivo model of anaplastic thyroid carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15044368&form=6&db=m Molecular mechanisms of the effects of low concentrations of taxol in anaplastic thyroid cancer cells. therapeutic application,unassigned 1,0 2.4.2.30 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16795079&form=6&db=m Effects of PPARgamma agonists on cell survival and focal adhesions in a Chinese thyroid carcinoma cell line. unassigned - 2.4.2.30 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18779313&form=6&db=m Association between polymorphisms in DNA base excision repair genes XRCC1, APE1, and ADPRT and differentiated thyroid carcinoma. causal interaction,unassigned 3,0 2.4.2.30 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20228127&form=6&db=m Human sodium-iodide symporter (hNIS) gene expression is inhibited by a trans-active transcriptional repressor, NIS-repressor, containing PARP-1 in thyroid cancer cells. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22982218&form=6&db=m The PARP inhibitor PJ34 modifies proliferation, NIS expression and epigenetic marks in thyroid cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25705225&form=6&db=m Synergy between HDAC and PARP Inhibitors on Proliferation of a Human Anaplastic Thyroid Cancer-Derived Cell Line. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26334619&form=6&db=m Anti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCP. ongoing research,unassigned 1,0 2.4.2.30 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28086241&form=6&db=m LncRNA-SLC6A9-5:2: A potent sensitizer in 131I-resistant papillary thyroid carcinoma with PARP-1 induction. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.4.2.30 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28790138&form=6&db=m Amifostine does not protect thyroid cancer cells in DNA damaging in vitro models. unassigned - 2.4.2.30 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30183716&form=6&db=m Interaction among susceptibility genotypes of PARP1 SNPs in thyroid carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,2 2.4.2.30 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30481266&form=6&db=m Computational modeling reveals MAP3K8 as mediator of resistance to vemurafenib in thyroid cancer stem cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34035807&form=6&db=m Galectin-3 Inhibitors Suppress Anoikis Resistance and Invasive Capacity in Thyroid Cancer Cells. unassigned - 2.4.2.30 Thyroiditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27081507&form=6&db=m Association of three SNPs in the PARP-1 gene with Hashimoto's thyroiditis. ongoing research,unassigned 4,0 2.4.2.30 Tics http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23370278&form=6&db=m Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest. therapeutic application,unassigned 1,0 2.4.2.30 Torsades de Pointes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32128485&form=6&db=m PARP inhibitor-induced torsades de pointes in long QT syndrome: a case report. causal interaction,unassigned 4,0 2.4.2.30 Tourette Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23576132&form=6&db=m Association of poly(ADP-ribose) polymerase-1 polymorphism with Tourette syndrome. causal interaction,unassigned 2,0 2.4.2.30 Trauma, Nervous System http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12570705&form=6&db=m Poly(ADP-ribose) polymerase inhibitors. causal interaction,unassigned 4,0 2.4.2.30 Tremor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11673569&form=6&db=m Induction of type 1 immune pathology in the brain following immunization without central nervous system autoantigen in transgenic mice with astrocyte-targeted expression of IL-12. ongoing research,unassigned 2,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19351835&form=6&db=m Defective repair of oxidative dna damage in triple-negative breast cancer confers sensitivity to inhibition of poly(ADP-ribose) polymerase. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20060649&form=6&db=m Triple-negative breast cancer: molecular features, pathogenesis, treatment and current lines of research. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20164690&form=6&db=m Poly(ADP-ribose) polymerase inhibitors in triple-negative breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20373860&form=6&db=m PARP inhibitors in BRCA1-/BRCA2-associated and triple-negative breast cancers. therapeutic application,unassigned 4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20406170&form=6&db=m Inducing Synthetic Lethality using PARP Inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20798217&form=6&db=m Synergistic chemosensitivity of triple-negative breast cancer cell lines to poly(ADP-Ribose) polymerase inhibition, gemcitabine, and cisplatin. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20799148&form=6&db=m Iniparib, a PARP1 inhibitor for the potential treatment of cancer, including triple-negative breast cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20802015&form=6&db=m A marker of homologous recombination predicts pathological complete response to neoadjuvant chemotherapy in primary breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20858840&form=6&db=m Poly(ADP-Ribose) polymerase inhibition: "Targeted" therapy for triple-negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21157412&form=6&db=m PARP Inhibitors in Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21504625&form=6&db=m Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,4 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21630056&form=6&db=m Can patients with metastatic breast cancer be cured after introduction of newer and more effective agents? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21681448&form=6&db=m Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21707865&form=6&db=m Response of subtype-specific human breast cancer-derived cells to poly(ADP-ribose) polymerase and checkpoint kinase 1 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21715566&form=6&db=m CMF revisited in the 21st century. therapeutic application,unassigned 4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21779231&form=6&db=m Current Issues of Targeted Therapy in Metastatic Triple-Negative Breast Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21779467&form=6&db=m Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21884642&form=6&db=m Poly(ADP-ribose) polymerase inhibition: a new direction for BRCA and triple-negative breast cancer? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21916578&form=6&db=m Therapeutic potential of PARP inhibitors for metastatic breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22106552&form=6&db=m PARP inhibitors in breast cancer: BRCA and beyond. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22263793&form=6&db=m Triple-negative breast cancer and Poly(ADP-ribose) polymerase inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22295252&form=6&db=m Current Status of Poly(ADP-ribose) Polymerase Inhibitors as Novel Therapeutic Agents for Triple-Negative Breast Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22655123&form=6&db=m PARP Inhibitors for the Treatment and Prevention of Breast Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22678161&form=6&db=m Differential anti-proliferative activities of poly(ADP-ribose) polymerase (PARP) inhibitors in triple-negative breast cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22706117&form=6&db=m [PARP inhibitors--theoretical basis and clinical application]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22915752&form=6&db=m PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA proficient triple negative breast cancer to PARP inhibition. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22933245&form=6&db=m Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23071597&form=6&db=m Synthetic lethal interactions between EGFR and PARP inhibition in human triple negative breast cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23293602&form=6&db=m Is there an epigenetic component underlying the resistance of triple-negative breast cancers to parp inhibitors? causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23564760&form=6&db=m Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor. therapeutic application,unassigned 4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23605692&form=6&db=m Using multiple targeted therapies in oncology: considerations for use, and progress to date in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23810467&form=6&db=m A Phase 1 trial of the poly(ADP-ribose) polymerase inhibitor olaparib (AZD2281) in combination with the anti-angiogenic cediranib (AZD2171) in recurrent epithelial ovarian or triple-negative breast cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23988612&form=6&db=m Targeted therapy for breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24063698&form=6&db=m Phase I trial of the oral PARP inhibitor olaparib in combination with paclitaxel for first- or second-line treatment of patients with metastatic triple-negative breast cancer. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24129347&form=6&db=m Appraising iniparib, the PARP inhibitor that never was--what must we learn? causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24379250&form=6&db=m [Triple-negative breast cancer: molecular characteristics and potential therapeutic approaches]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24420152&form=6&db=m INPP4B overexpression enhances the antitumor efficacy of PARP inhibitor AG014699 in MDA-MB-231 triple-negative breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24563619&form=6&db=m Doubling down on the PI3K-AKT-mTOR pathway enhances the antitumor efficacy of PARP inhibitor in triple negative breast cancer model beyond BRCA-ness. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24791791&form=6&db=m [Effects of poly(ADP-ribose)polymerase inhibitor AG014699 combined with chemotherapy on the proliferation of triple-negative breast cancer cell line MDA-MB-231]. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24829621&form=6&db=m Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25026298&form=6&db=m Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25202071&form=6&db=m Decreased miR-206 expression in BRCA1 wild-type triple-negative breast cancer cells after concomitant treatment with gemcitabine and a Poly(ADP-ribose) polymerase-1 inhibitor. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25738259&form=6&db=m Erratum to "Doubling Down on the PI3K-AKTmTOR Pathway Enhances the Antitumor Efficacy of PARP Inhibitor in Triple Negative Breast Cancer Model beyond BRCA-ness" [Neoplasia 16 (2014) 43-72]. therapeutic application,unassigned 2,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25774912&form=6&db=m Protein expression of DNA damage repair proteins dictates response to topoisomerase and PARP inhibitors in triple-negative breast cancer. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25888415&form=6&db=m Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti-tumor effects of the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib in triple-negative breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26015868&form=6&db=m Pan-cancer analysis of genomic scar signatures associated with homologous recombination deficiency suggests novel indications for existing cancer drugs. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26261599&form=6&db=m Polymorphisms in poly (ADP-ribose) polymerase-1 (PARP1) promoter and 3' untranslated region and their association with PARP1 expression in breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26546619&form=6&db=m mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26563438&form=6&db=m Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization. ongoing research,unassigned 3,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26577420&form=6&db=m Expression of potential biomarkers associated with homologous recombination repair in patients with ovarian or triple-negative breast cancer. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26801247&form=6&db=m Phase I Study of Veliparib (ABT-888) Combined with Cisplatin and Vinorelbine in Advanced Triple-Negative Breast Cancer and/or BRCA Mutation-Associated Breast Cancer. therapeutic application,unassigned 1,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26996385&form=6&db=m Randomized phase II trial of cyclophosphamide and the oral poly (ADP-ribose) polymerase inhibitor veliparib in patients with recurrent, advanced triple-negative breast cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27880910&form=6&db=m CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27920426&form=6&db=m Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27994514&form=6&db=m The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28034904&form=6&db=m RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28176879&form=6&db=m PARP inhibitor increases chemosensitivity by upregulating miR-664b-5p in BRCA1-mutated triple-negative breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28249538&form=6&db=m PARP inhibitor and platinum agent in triple negative breast cancer: utilizing innovative trial design to bring together something "new" and something "old". unassigned - 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28300203&form=6&db=m Corrigendum: PARP inhibitor increases chemosensitivity by upregulating miR-664b-5p in BRCA1-mutated triple-negative breast cancer. unassigned - 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28359295&form=6&db=m Rad51 inhibition sensitizes breast cancer stem cells to PARP inhibitor in triple-negative breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28442756&form=6&db=m Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28790402&form=6&db=m H-Ferritin-nanocaged olaparib: a promising choice for both BRCA-mutated and sporadic triple negative breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28893315&form=6&db=m Heterogeneous drug penetrance of veliparib and carboplatin measured in triple negative breast tumors. therapeutic application,unassigned 4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28958991&form=6&db=m Pathway-Enriched Gene Signature Associated with 53BP1 Response to PARP Inhibition in Triple-Negative Breast Cancer. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29063517&form=6&db=m PARP Inhibitors in the Treatment of Triple-Negative Breast Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29152062&form=6&db=m Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29179249&form=6&db=m Judy Garber on PARP Inhibitors for Triple-Negative Breast Cancer. therapeutic application,unassigned 4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29180466&form=6&db=m Synthetic Lethality of PARP Inhibitors in Combination with MYC Blockade Is Independent of BRCA Status in Triple-Negative Breast Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29282689&form=6&db=m BRCA Gene Mutations and Poly(ADP-Ribose) Polymerase Inhibitors in Triple-Negative Breast Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29312562&form=6&db=m Downregulation of miR-221-3p and upregulation of its target gene PARP1 are prognostic biomarkers for triple negative breast cancer patients and associated with poor prognosis. causal interaction,diagnostic usage,unassigned 4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29501363&form=6&db=m Addition of the PARP inhibitor veliparib plus carboplatin or carboplatin alone to standard neoadjuvant chemotherapy in triple-negative breast cancer (BrighTNess): a randomised, phase 3 trial. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29753961&form=6&db=m The role of PARP inhibition in triple-negative breast cancer: Unraveling the wide spectrum of synthetic lethality. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29902865&form=6&db=m Co-targeting poly(ADP-ribose) polymerase (PARP) and histone deacetylase (HDAC) in triple-negative breast cancer: Higher synergism in BRCA mutated cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30100991&form=6&db=m Prosopis juliflora (Sw.), DC induces apoptosis and cell cycle arrest in triple negative breast cancer cells: in vitro and in vivo investigations. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30211078&form=6&db=m Gallic acid and curcumin induce cytotoxicity and apoptosis in human breast cancer cell MDA-MB-231. causal interaction,unassigned 3,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30289618&form=6&db=m HMGA2 as a functional antagonist of PARP1 inhibitors in tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30323975&form=6&db=m Deglycosylation of PD-L1 by 2-deoxyglucose reverses PARP inhibitor-induced immunosuppression in triple-negative breast cancer. unassigned - 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30429212&form=6&db=m PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30442946&form=6&db=m PARP3, a new therapeutic target to alter Rictor/mTORC2 signaling and tumor progression in BRCA1-associated cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30580238&form=6&db=m Effect of AR antagonist combined with PARP1 inhibitor on sporadic triple-negative breast cancer bearing AR expression and methylation-mediated BRCA1 dysfunction. therapeutic application,unassigned 3,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30672063&form=6&db=m BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30726707&form=6&db=m Corrigendum to "Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization" [Nanomedicine 12 (3) (2016), 745-757]. ongoing research,unassigned 1,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30789866&form=6&db=m Integrating poly(ADP-ribose) polymerase (PARP) inhibitors in the treatment of early breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30800714&form=6&db=m Translating the role of PARP inhibitors in triple-negative breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30824588&form=6&db=m MUC1-C Integrates Chromatin Remodeling and PARP1 Activity in the DNA Damage Response of Triple-Negative Breast Cancer Cells. therapeutic application,unassigned 1,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31015319&form=6&db=m PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31106005&form=6&db=m Metformin reverses PARP inhibitors-induced epithelial-mesenchymal transition and PD-L1 upregulation in triple-negative breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31194214&form=6&db=m Immune Checkpoint and Poly(ADP-Ribose) Polymerase Inhibition for Recurrent Platinum-Resistant Ovarian and Metastatic Triple-Negative Breast Cancers. causal interaction,unassigned 1,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31375040&form=6&db=m PARP Inhibitor Olaparib Use in a BRCA1-Positive Patient With Metastatic Triple-Negative Breast Cancer, Without the Initial Use of Platinum-Based Chemotherapy, Showing Significant Rapid Near Resolution of Large Liver Metastasis While Patient Experienced Gout-Like Symptoms. causal interaction,unassigned 1,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31541611&form=6&db=m DDB2 depletion sensitizes triple-negative breast cancer cells to PARP inhibition by destabilizing Rad51. unassigned - 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31715127&form=6&db=m Induction of BRCAness in Triple-Negative Breast Cancer by a CDK12/13 Inhibitor Improves Chemotherapy. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31898884&form=6&db=m Metallointercalator [Ru(dppz)2(PIP)]2+ Renders BRCA Wild-Type Triple-Negative Breast Cancer Cells Hypersensitive to PARP Inhibition. therapeutic application,unassigned 4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32023457&form=6&db=m A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32053991&form=6&db=m Establishment and Characterization of a Brca1-/-, p53-/- Mouse Mammary Tumor Cell Line. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32055930&form=6&db=m Phase I and pharmacokinetic study of veliparib, a PARP inhibitor, and pegylated liposomal doxorubicin (PLD) in recurrent gynecologic cancer and triple negative breast cancer with long-term follow-up. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32177621&form=6&db=m Association BRCA mutation status between BMN 673 (talazoparib), an oral PARP inhibitor, in triple-negative breast cancer. causal interaction,unassigned 1,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32195033&form=6&db=m Blocking c-Met and EGFR reverses acquired resistance of PARP inhibitors in triple-negative breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32355298&form=6&db=m Polymorphisms in PARP1 predict disease-free survival of triple-negative breast cancer patients treated with anthracycline/taxane based adjuvant chemotherapy. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,2,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32455851&form=6&db=m Transcriptional Regulation of CCL2 by PARP1 Is a Driver for Invasiveness in Breast Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32471999&form=6&db=m Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32539467&form=6&db=m ABC4 Consensus: First Latin American Meeting-Assessment, Comments, and Application of Its Recommendations. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32555285&form=6&db=m Antitumor effect of a WEE1 inhibitor and potentiation of olaparib sensitivity by DNA damage response modulation in triple-negative breast cancer. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32630796&form=6&db=m Zebrafish Xenografts Unveil Sensitivity to Olaparib beyond BRCA Status. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32726747&form=6&db=m Augmentation of the antitumor effects of PARP inhibitors in triple-negative breast cancer via degradation by hydrophobic tagging modulation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32920355&form=6&db=m Design and synthesis of some barbituric and 1,3-dimethylbarbituric acid derivatives: A non-classical scaffold for potential PARP1 inhibitors. ongoing research,unassigned 1,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32923140&form=6&db=m Adoptive cell therapy of triple negative breast cancer with redirected cytokine-induced killer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32971187&form=6&db=m Combination of Olaparib and radiotherapy for triple negative breast cancer: preliminary results of the RADIOPARP phase I trial. therapeutic application,unassigned 4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33003585&form=6&db=m Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization against PARP1 Inhibition in a Replication-Dependent Manner. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33200929&form=6&db=m Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer. therapeutic application,unassigned 4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33205541&form=6&db=m PARP1 and PRC2 double deficiency promotes BRCA-proficient breast cancer growth by modification of the tumor microenvironment. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33231937&form=6&db=m New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33278482&form=6&db=m Dextran-modified Quercetin-Cu(II)/hyaluronic acid nanomedicine with natural poly(ADP-ribose) polymerase inhibitor and dual targeting for programmed synthetic lethal therapy in triple-negative breast cancer. therapeutic application,unassigned 4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33309164&form=6&db=m Discovery of novel PARP/PI3K dual inhibitors with high efficiency against BRCA-proficient triple negative breast cancer. therapeutic application,unassigned 4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33324554&form=6&db=m New Perspectives for Resistance to PARP Inhibitors in Triple-Negative Breast Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33330019&form=6&db=m MiRNA and LncRNA as Potential Biomarkers in Triple-Negative Breast Cancer: A Review. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33412559&form=6&db=m Modulation of Early Mitotic Inhibitor 1 (EMI1) depletion on the sensitivity of PARP inhibitors in BRCA1 mutated triple-negative breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33425022&form=6&db=m XRCC1 deficient triple negative breast cancers are sensitive to ATR, ATM and Wee1 inhibitor either alone or in combination with olaparib. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33468723&form=6&db=m [Effects of Olaparib, a PARP-1 Inhibitor, on Triple Negative Breast Cancer Cells with a BRCA1 Mutation]. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33470989&form=6&db=m p66ShcA potentiates the cytotoxic response of triple-negative breast cancers to PARP inhibitors. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33475295&form=6&db=m PARP Inhibitors in Triple-Negative Breast Cancer Including Those With BRCA Mutations. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33598323&form=6&db=m Expert Insights on Triple-Negative Breast Cancer: Preparing for the Next Wave of Treatments. therapeutic application,unassigned 4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33628586&form=6&db=m The cancer-testis gene, MEIOB, sensitizes triple-negative breast cancer to PARP1 inhibitors by inducing homologous recombination deficiency. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,3 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33637776&form=6&db=m BKM120 sensitizes BRCA-proficient triple negative breast cancer cells to olaparib through regulating FOXM1 and Exo1 expression. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33652085&form=6&db=m Blocking Fra-1 sensitizes triple-negative breast cancer to PARP inhibitor. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33738458&form=6&db=m Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33832512&form=6&db=m Efficacy and mechanism of the combination of PARP and CDK4/6 inhibitors in the treatment of triple-negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33933153&form=6&db=m Functional consequences of a rare missense BARD1 c.403G>A germline mutation identified in a triple-negative breast cancer patient. causal interaction,unassigned 1,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34136083&form=6&db=m Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34145034&form=6&db=m E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer. therapeutic application,unassigned 1,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34208492&form=6&db=m New RAD51 Inhibitors to Target Homologous Recombination in Human Cells. therapeutic application,unassigned 2,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34270809&form=6&db=m Combination of Olaparib with radiotherapy for triple-negative breast cancers: One-year toxicity report of the RADIOPARP Phase I trial. therapeutic application,unassigned 4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34388456&form=6&db=m CHFR-mediated degradation of RNF126 confers sensitivity to PARP inhibitors in triple-negative breast cancer cells. therapeutic application,unassigned 4,0 2.4.2.30 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34455779&form=6&db=m Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1554491&form=6&db=m Induction of polyclonal antibodies to the S1 subunit of pertussis toxin by synthetic peptides coupled to PPD: effect of conjugation method, adjuvant, priming and animal species. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8095458&form=6&db=m Protection against autoimmune disease by bacterial agents. II. PPD and pertussis toxin as proteins active in protecting mice against experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9174984&form=6&db=m Use of type I and type IV hypersensitivity responses to define the immunopharmacological profile of drugs. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12202519&form=6&db=m Spontaneous induction of immunoregulation by an endogenous retinal antigen. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 2.4.2.30 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15082117&form=6&db=m Is rheumatoid arthritis a consequence of natural selection for enhanced tuberculosis resistance? causal interaction,unassigned 4,0 2.4.2.30 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19264905&form=6&db=m Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19330217&form=6&db=m Mechanical hypernociception in experimental autoimmune encephalomyelitis. ongoing research,unassigned 2,0 2.4.2.30 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26911613&form=6&db=m Early IFN-? production together with decreased expression of TLR3 and TLR9 characterizes EAE development conditional on the presence of myelin. therapeutic application,unassigned 1,0 2.4.2.30 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31522437&form=6&db=m Evaluation of IL-17 Serum Level, Brain Inflammation and Demyelination in Experimental Autoimmune Encephalomyelitis C57BL/6 Mice Model with Different Doses of Myelin Oligodendrocyte Glycoprotein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31960801&form=6&db=m Protective effects of pharmacological therapies in animal models of multiple sclerosis: a review of studies 2014-2019. unassigned - 2.4.2.30 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33189793&form=6&db=m Titration of myelin oligodendrocyte glycoprotein (MOG) - Induced experimental autoimmune encephalomyelitis (EAE) model. unassigned - 2.4.2.30 Typhoid Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1398937&form=6&db=m Specific lung mucosal and systemic immune responses after oral immunization of mice with Salmonella typhimurium aroA, Salmonella typhi Ty21a, and invasive Escherichia coli expressing recombinant pertussis toxin S1 subunit. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21613422&form=6&db=m Loss of poly(ADP-ribose) polymerase 1 attenuates renal fibrosis and inflammation during unilateral ureteral obstruction. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10475354&form=6&db=m Intravesical therapy with pertussis toxin before radical cystectomy in patients with bladder cancer: a Phase I study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16216409&form=6&db=m Overexpression of PML induced apoptosis in bladder cancer cell by caspase dependent pathway. unassigned - 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16253165&form=6&db=m [The molecular mechanism of PML in inducing apoptosis of bladder cancer cell line] causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17203305&form=6&db=m Genetic variation in the base excision repair pathway and bladder cancer risk. diagnostic usage,unassigned 3,0 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17220334&form=6&db=m High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19040745&form=6&db=m Immunomodulatory effects of recombinant BCG expressing pertussis toxin on TNF-alpha and IL-10 in a bladder cancer model. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19074857&form=6&db=m 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. unassigned - 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20218899&form=6&db=m Genetic Variants of XRCC1, APE1, and ADPRT Genes and Risk of Bladder Cancer. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20846399&form=6&db=m Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22166496&form=6&db=m The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23483488&form=6&db=m Overexpression of immunoglobulin G prompts cell proliferation and inhibits cell apoptosis in human urothelial carcinoma. unassigned - 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26873485&form=6&db=m The SMAD2/3 pathway is involved in hepaCAM-induced apoptosis by inhibiting the nuclear translocation of SMAD2/3 in bladder cancer cells. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27595989&form=6&db=m CD44 and RHAMM are essential for rapid growth of bladder cancer driven by loss of Glycogen Debranching Enzyme (AGL). causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28433067&form=6&db=m Chloroquine and hydroxychloroquine inhibit bladder cancer cell growth by targeting basal autophagy and enhancing apoptosis. unassigned - 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28502307&form=6&db=m [Knock-down of DAB2 interacting protein (DAB2IP) promotes proliferation and inhibits apoptosis of bladder cancer cells]. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29511347&form=6&db=m PARP-1 inhibition with or without ionizing radiation confers reactive oxygen species-mediated cytotoxicity preferentially to cancer cells with mutant TP53. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30791940&form=6&db=m New combinatorial strategies to improve the PARP inhibitors efficacy in the urothelial bladder Cancer treatment. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31297119&form=6&db=m In vitro Evidence of Human Immune Responsiveness Shows the Improved Potential of a Recombinant BCG Strain for Bladder Cancer Treatment. therapeutic application,unassigned 3,0 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32277642&form=6&db=m Heptaphylline suppresses the proliferation and migration of human bladder cancer cells via induction of intrinsic apoptosis, autophagy and inhibition of ?-catenin signalling pathway. unassigned - 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33947694&form=6&db=m Detection of Molecular Signatures of Homologous Recombination Deficiency in Bladder Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34044254&form=6&db=m Guggulsterone induces apoptosis and inhibits lysosomal-dependent migration in human bladder cancer cells. unassigned - 2.4.2.30 Urinary Retention http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21416227&form=6&db=m PARP inhibition prevents oxidative injury of bladder induced by acute urinary retention and subsequent emptying. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9481486&form=6&db=m Differential osmosensing signalling pathways and G-protein involvement in human cervical cells with different tumour potential. ongoing research,unassigned 3,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12892828&form=6&db=m Emodin induces apoptosis of human cervical cancer cells through poly(ADP-ribose) polymerase cleavage and activation of caspase-9. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15604259&form=6&db=m Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18695944&form=6&db=m Induction of apoptosis by the inhibitors of poly(ADP-ribose)polymerase in HeLa cells. therapeutic application,unassigned 3,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19424586&form=6&db=m Synergistic interaction between tetra-arsenic oxide and paclitaxel in human cancer cells in vitro. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19574249&form=6&db=m Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells. causal interaction,unassigned 1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20878065&form=6&db=m Triptolide inactivates Akt and induces caspase-dependent death in cervical cancer cells via the mitochondrial pathway. unassigned - 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22454210&form=6&db=m Expression of BAG-1 and PARP-1 in Precursor Lesions and Invasive Cervical Cancer Associated with Human Papillomavirus (HPV). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22740911&form=6&db=m Single nucleotide polymorphisms in DNA repair genes and risk of cervical cancer: A case-control study. ongoing research,unassigned 1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23633189&form=6&db=m Involvement of PARP-1 Val762Ala polymorphism in the onset of cervical cancer in caucasian women. therapeutic application,unassigned 1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24098868&form=6&db=m The Role of PARP Inhibitors in the Treatment of Gynecologic Malignancies. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25594147&form=6&db=m A Phase I-II Evaluation of Veliparib (NSC #737664), Topotecan, and Filgrastim or Pegfilgrastim in the Treatment of Persistent or Recurrent Carcinoma of the Uterine Cervix: An NRG Oncology/Gynecologic Oncology Group Study. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26214194&form=6&db=m Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect. therapeutic application,unassigned 4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26439985&form=6&db=m B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26474854&form=6&db=m Bcl-2 confers survival in cisplatin treated cervical cancer cells: circumventing cisplatin dose-dependent toxicity and resistance. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26905326&form=6&db=m Poly(ADP-Ribose) Polymerase in Cervical Cancer Pathogenesis: Mechanism and Potential Role for PARP Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26926322&form=6&db=m Beyond Chemotherapy: An Overview and Review of Targeted Therapy in Cervical Cancer. therapeutic application,unassigned 4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27323894&form=6&db=m Base excision repair pathway: PARP1 genotypes as modulators of therapy response in cervical cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27470347&form=6&db=m Interferon ? improves the efficacy of low dose cisplatin by inhibiting NF-?B/p-Akt signaling on HeLa cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27824155&form=6&db=m Cucurbitacin D exhibits potent anti-cancer activity in cervical cancer. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27998970&form=6&db=m A phase I trial of paclitaxel, cisplatin, and veliparib in the treatment of persistent or recurrent carcinoma of the cervix: an NRG Oncology Study (NCT#01281852). ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28131528&form=6&db=m Expression of DNA damage response proteins in cervical cancer patients treated with radical chemoradiotherapy. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28208804&form=6&db=m Hazelnut (Corylus avellana L.) Shells Extract: Phenolic Composition, Antioxidant Effect and Cytotoxic Activity on Human Cancer Cell Lines. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28505207&form=6&db=m Immuno-related polymorphisms and cervical cancer risk: The IARC multicentric case-control study. diagnostic usage,unassigned 1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28800469&form=6&db=m Immunotherapy in ovarian, endometrial and cervical cancer: State of the art and future perspectives. therapeutic application,unassigned 3,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28993682&form=6&db=m Olaparib modulates DNA repair efficiency, sensitizes cervical cancer cells to cisplatin and exhibits anti-metastatic property. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29309290&form=6&db=m Blockade of BAFF Receptor BR3 on T Cells Enhances Their Activation and Cytotoxicity. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29852177&form=6&db=m RHCG suppresses cervical cancer progression through inhibiting migration and inducing apoptosis regulated by TGF-?1. causal interaction,unassigned 1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29872938&form=6&db=m The poly (ADP-ribose) polymerase inhibitor rucaparib suppresses proliferation and serves as an effective radiosensitizer in cervical cancer. therapeutic application,unassigned 4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29944886&form=6&db=m Down-regulation of LHPP in cervical cancer influences cell proliferation, metastasis and apoptosis by modulating AKT. causal interaction,unassigned 4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30020984&form=6&db=m Potential biomarkers and therapeutic targets in cervical cancer: Insights from the meta-analysis of transcriptomics data within network biomedicine perspective. diagnostic usage,unassigned 1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30127625&form=6&db=m MSX1 induces G0/G1 arrest and apoptosis by suppressing Notch signaling and is frequently methylated in cervical cancer. unassigned - 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30219819&form=6&db=m MicroRNA-7-5p Promotes Cisplatin Resistance of Cervical Cancer Cells and Modulation of Cellular Energy Homeostasis by Regulating the Expression of the PARP-1 and BCL2 Genes. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30283446&form=6&db=m Gene Expression Analysis Identifies Novel Targets for Cervical Cancer Therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30454902&form=6&db=m MFAP5 suppression inhibits migration/invasion, regulates cell cycle and induces apoptosis via promoting ROS production in cervical cancer. therapeutic application,unassigned 1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30858762&form=6&db=m Up-regulated lncRNA XIST contributes to progression of cervical cancer via regulating miR-140-5p and ORC1. diagnostic usage,unassigned 3,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31069647&form=6&db=m Current Systemic Treatment Landscape of Advanced Gynecologic Malignancies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31303961&form=6&db=m PARP-1 inhibitor modulate ?-catenin signaling to enhance cisplatin sensitivity in cancer cervix. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31434613&form=6&db=m PARP-1 activity (PAR) determines the sensitivity of cervical cancer to olaparib. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31545455&form=6&db=m PI3K p110? inhibition sensitizes cervical cancer cells with aberrant PI3K signaling activation to PARP inhibitor BMN673. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31637455&form=6&db=m MiRNA-211 triggers an autophagy-dependent apoptosis in cervical cancer cells: regulation of Bcl-2. unassigned - 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31797547&form=6&db=m Identification of Vaccinia-H1 Related Phosphatase as an Anticancer Target for 1,2,3,4,6-O-Pentagalloylglucose. unassigned - 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31816985&form=6&db=m The Anti-Proliferative Activity of the Hybrid TMS-TMF-4f Compound Against Human Cervical Cancer Involves Apoptosis Mediated by STAT3 Inactivation. unassigned - 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31912897&form=6&db=m Targeting cervical cancer: Is there a role for poly (ADP-ribose) polymerase inhibition? causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32262124&form=6&db=m Rational design and fabrication of a cancer-targeted chitosan nanocarrier to enhance selective cellular uptake and anticancer efficacy of selenocystine. ongoing research,unassigned 3,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32711558&form=6&db=m MAPK4 deletion enhances radiation effects and triggers synergistic lethality with simultaneous PARP1 inhibition in cervical cancer. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32717310&form=6&db=m Rucaparib antagonize multidrug resistance in cervical cancer cells through blocking the function of ABC transporters. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33042417&form=6&db=m Atorvastatin suppresses the progression of cervical cancer via regulation of autophagy. therapeutic application,unassigned 1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33188153&form=6&db=m Poly(ADP-ribose)polymerase1: A potential molecular marker to identify cancer during colposcopy procedures. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33417305&form=6&db=m RNF114 suppresses metastasis through regulation of PARP10 in cervical cancer cells. therapeutic application,unassigned 1,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33480316&form=6&db=m Structure-activity insights of harmine targeting DNA, ROS inducing cytotoxicity with PARP mediated apoptosis against cervical cancer, anti-biofilm formation and in vivo therapeutic study. therapeutic application,unassigned 3,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33888155&form=6&db=m Complete pathological response to olaparib and bevacizumab in advanced cervical cancer following chemoradiation in a BRCA1 mutation carrier: a case report. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34076351&form=6&db=m PD-L1, PARP1, and MMRs as potential therapeutic biomarkers for neuroendocrine cervical cancer. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531868&form=6&db=m Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.4.2.30 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11418656&form=6&db=m Pertussis toxin inhibits induction of tissue-specific autoimmune disease by disrupting G protein-coupled signals. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026317&form=6&db=m Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies. causal interaction,unassigned 3,0 2.4.2.30 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20700542&form=6&db=m Paradoxical effect of pertussis toxin on the delayed hypersensitivity response to autoantigens in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25863040&form=6&db=m Mycophenolate mofetil and cyclophosphamide treatments suppress inflammation intensity in an experimental model of autoimmune uveitis. therapeutic application,unassigned 3,0 2.4.2.30 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26558361&form=6&db=m The critical points in induction of experimental autoimmune uveitis. therapeutic application,unassigned 2,0 2.4.2.30 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29068389&form=6&db=m Clinical Effect of IRT-5 Probiotics on Immune Modulation of Autoimmunity or Alloimmunity in the Eye. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Uveitis, Anterior http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1358666&form=6&db=m Experimental autoimmune anterior uveitis (EAAU). II. Dose-dependent induction and adoptive transfer using a melanin-bound antigen of the retinal pigment epithelium. ongoing research,unassigned 1,0 2.4.2.30 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11259186&form=6&db=m Molluscum contagiosum virus inhibitors of apoptosis: The MC159 v-FLIP protein blocks Fas-induced activation of procaspases and degradation of the related MC160 protein. unassigned - 2.4.2.30 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14610284&form=6&db=m Vaccinia virus encodes a previously uncharacterized mitochondrial-associated inhibitor of apoptosis. ongoing research,unassigned 2,0 2.4.2.30 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18096829&form=6&db=m Galectin-3 is an amplifier of inflammation in atherosclerotic plaque progression through macrophage activation and monocyte chemoattraction. ongoing research,unassigned 2,0 2.4.2.30 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31217354&form=6&db=m PARP-1 controls NK cell recruitment to the site of viral infection. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Varicocele http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20629644&form=6&db=m Effects of varicocele upon the expression of apoptosis-related proteins. causal interaction,diagnostic usage,unassigned 3,1,0 2.4.2.30 Varicocele http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21436309&form=6&db=m Potential Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Experimental Left Varicocele. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.4.2.30 Varicocele http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27992945&form=6&db=m Inhibition of poly(ADP-ribose) polymerase may have preventive potential for varicocoele-associated testicular damage in rats. causal interaction,unassigned 3,0 2.4.2.30 Varicose Veins http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11331852&form=6&db=m Expression of molecular mediators of apoptosis and their role in the pathogenesis of lower-extremity varicose veins. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Vascular Calcification http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30867423&form=6&db=m Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10771174&form=6&db=m The neuroprotective effect of cerebral poly(ADP-ribose)polymerase inhibition in a rat model of global ischemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15258350&form=6&db=m Hemorheological methods in drug research. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25872931&form=6&db=m Effect and mechanism of poly (ADP-ribose) polymerase-1 in aldosterone-induced apoptosis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30354818&form=6&db=m PARP-1 (Poly[ADP-Ribose] Polymerase 1) Inhibition Protects From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm in Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Vascular Ring http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9214448&form=6&db=m Enhanced G-protein-induced relaxation in portal hypertensive rats: role of nitric oxide. ongoing research,unassigned 2,0 2.4.2.30 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11511974&form=6&db=m Diabetic endothelial dysfunction: role of reactive oxygen and nitrogen species production and poly(ADP-ribose) polymerase activation. therapeutic application,unassigned 3,0 2.4.2.30 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15681711&form=6&db=m Poly(ADP-ribose) polymerase inhibitor PJ-34 reduces mesenteric vascular injury induced by experimental cardiopulmonary bypass with cardiac arrest. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 2.4.2.30 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11136941&form=6&db=m Inhibition of poly(ADP-ribose) polymerase attenuates cerebral vasospasm after subarachnoid hemorrhage in rabbits. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30680005&form=6&db=m Potential role of poly (ADP-ribose) polymerase in delayed cerebral vasospasm following subarachnoid hemorrhage in rats. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Ventilator-Induced Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18718025&form=6&db=m Inflammatory and transcriptional roles of poly (ADP-ribose) polymerase in ventilator-induced lung injury. diagnostic usage,ongoing research,unassigned 2,4,0 2.4.2.30 Ventilator-Induced Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18983699&form=6&db=m The role of poly (ADP-ribose) polymerase in ventilator-induced lung injury. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Ventricular Premature Complexes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8963956&form=6&db=m Mechanism of epinephrine-induced dysrhythmias in rat involves local cholinergic activation. therapeutic application,unassigned 1,0 2.4.2.30 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12414932&form=6&db=m Poly(ADP-ribose) polymerase 1 is not strictly required for infection of murine cells by retroviruses. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 2.4.2.30 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15709017&form=6&db=m DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30988430&form=6&db=m ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase ?-TrCP. therapeutic application,unassigned 1,0 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2174674&form=6&db=m Reovirus transport--studies using lymphocytosis promoting factor. ongoing research,unassigned 1,0 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7639731&form=6&db=m Poly(ADP-ribose) polymerase activity in various U937 cell subclones with different susceptibility to HIV-1 infection: its dramatic decrease following persistent virus infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9178501&form=6&db=m Induction of apoptosis and cleavage of poly(ADP-ribose) polymerase by cytopathic bovine viral diarrhea virus infection. causal interaction,unassigned 1,0 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10979896&form=6&db=m Pertussis toxin sensitization alters the pathogenesis of subsequent respiratory syncytial virus infection. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11248084&form=6&db=m Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11853409&form=6&db=m Rapid activation of poly(ADP-ribose) polymerase contributes to Sindbis virus and staurosporine-induced apoptotic cell death. causal interaction,ongoing research,unassigned 2,4,0 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12359428&form=6&db=m Caspase-mediated cleavage of adenovirus early region 1A proteins. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15003865&form=6&db=m NuMA and nuclear lamins are cleaved during viral infection--inhibition of caspase activity prevents cleavage and rescues HeLa cells from measles virus-induced but not from rhinovirus 1B-induced cell death. causal interaction,unassigned 2,0 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15956583&form=6&db=m Flavivirus activates phosphatidylinositol 3-kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infection. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17430191&form=6&db=m Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30777922&form=6&db=m ARTC2.2/P2RX7 Signaling during Cell Isolation Distorts Function and Quantification of Tissue-Resident CD8+ T Cell and Invariant NKT Subsets. ongoing research,unassigned 3,0 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30988430&form=6&db=m ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase ?-TrCP. therapeutic application,unassigned 1,0 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31217354&form=6&db=m PARP-1 controls NK cell recruitment to the site of viral infection. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31285747&form=6&db=m Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31539774&form=6&db=m PARP-1 mediated cell death is directly activated by ZIKV infection. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32029452&form=6&db=m PARPs and ADP-ribosylation in RNA biology: from RNA expression and processing to protein translation and proteostasis. diagnostic usage,unassigned 1,0 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33467912&form=6&db=m The potential association between PARP14 and SARS-CoV-2 infection (COVID-19). causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33494667&form=6&db=m Role of Poly(ADP-ribose) Polymerase (PARP1) in Viral Infection and its Implication in SARS-CoV-2 Pathogenesis. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34037418&form=6&db=m Inhibition of PARP1 Dampens Pseudorabies Virus Infection through DNA Damage-Induced Antiviral Innate Immunity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34445373&form=6&db=m SARS-CoV-2: Understanding the Transcriptional Regulation of ACE2 and TMPRSS2 and the Role of Single Nucleotide Polymorphism (SNP) at Codon 72 of p53 in the Innate Immune Response against Virus Infection. unassigned - 2.4.2.30 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34485381&form=6&db=m NAD+ Degrading Enzymes, Evidence for Roles During Infection. unassigned - 2.4.2.30 Wasting Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29873790&form=6&db=m Hepatocyte-Specific Deletion of TIPARP, a Negative Regulator of the Aryl Hydrocarbon Receptor, Is Sufficient to Increase Sensitivity to Dioxin-Induced Wasting Syndrome. therapeutic application,unassigned 1,0 2.4.2.30 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10989122&form=6&db=m Repair of telomeric DNA prior to replicative senescence. unassigned - 2.4.2.30 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12707040&form=6&db=m Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice. unassigned - 2.4.2.30 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14734561&form=6&db=m Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1. ongoing research,unassigned 2,0 2.4.2.30 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15204703&form=6&db=m Identification of proteins in the hamster DNA end-binding complex. diagnostic usage,unassigned 1,0 2.4.2.30 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15292449&form=6&db=m Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein. unassigned - 2.4.2.30 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15590998&form=6&db=m Poly(ADP-ribosyl)ation, PARP, and aging. causal interaction,unassigned 1,0 2.4.2.30 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15642393&form=6&db=m Increased frequency of multiradial chromosome structures in mouse embryonic fibroblasts lacking functional Werner syndrome protein and poly(ADP-ribose) polymerase-1. ongoing research,unassigned 3,0 2.4.2.30 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15743677&form=6&db=m The emerging role of poly(ADP-ribose) polymerase-1 in longevity. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911337&form=6&db=m Ageing and PARP. causal interaction,unassigned 2,0 2.4.2.30 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16195394&form=6&db=m In vivo misregulation of genes involved in apoptosis, development and oxidative stress in mice lacking both functional Werner syndrome protein and poly(ADP-ribose) polymerase-1. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=233166&form=6&db=m Pertussis toxin: the cause of the harmful effects and prolonged immunity of whooping cough. A hypothesis. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1279450&form=6&db=m Peptidergic modulation of G-protein coupled cyclic-AMP accumulation in the rat caudate nucleus. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1279515&form=6&db=m Chloride channels in cultured human skeletal muscle are regulated by G proteins. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1279687&form=6&db=m GTP-binding proteins inhibit cAMP activation of chloride channels in cystic fibrosis airway epithelial cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1280103&form=6&db=m Endothelin rapidly stimulates mitogen-activated protein kinase activity in rat mesangial cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1280132&form=6&db=m ATP-induced Ca2+ influx is regulated via a pertussis toxin-sensitive mechanism in a PC12 cell clone. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1280235&form=6&db=m Pituitary adenylate cyclase polypeptide (PACAP) stimulates cyclic AMP formation in pituitary fibroblasts and 3T3 tumor fibroblasts: lack of enhancement by protein kinase C activation. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1280276&form=6&db=m In vitro model of angiogenesis using a human endothelium-derived permanent cell line: contributions of induced gene expression, G-proteins, and integrins. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1280320&form=6&db=m Identification of G-proteins in rat parotid gland plasma membranes and granule membranes: presence of distinct components in granule membranes. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1280455&form=6&db=m The prostacyclin analogues, cicaprost and iloprost, increase cytosolic Ca2+ concentration in the human erythroleukemia cell line, HEL, via pertussis toxin-insensitive G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1281475&form=6&db=m Investigation of the lectin-like binding domains in pertussis toxin using synthetic peptide sequences. Identification of a sialic acid binding site in the S2 subunit of the toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1281979&form=6&db=m Formyl peptides and ATP stimulate Ca2+ and Na+ inward currents through non-selective cation channels via G-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. Involvement of Ca2+ and Na+ in the activation of beta-glucuronidase release and superoxide production. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1282494&form=6&db=m Calcitonin gene-related peptide (CGRP) activates human neutrophils--inhibition by chemotactic peptide antagonist BOC-MLP. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1283453&form=6&db=m m4 muscarinic receptor subtype activates an inwardly rectifying potassium conductance in AtT20 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1284568&form=6&db=m Intracellular pathways triggered by galanin to induce contraction of pig ileum smooth muscle cells. diagnostic usage,ongoing research,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1284924&form=6&db=m Pertussis toxin stimulates the secretion of [Met5]-enkephalin and the expression of proenkephalin A mRNA in bovine adrenal medullary chromaffin cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1298436&form=6&db=m G-proteins mediate inhibition and activation of Ca(2+)-induced exocytosis from SLO-permeabilized peptidergic nerve endings. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1300489&form=6&db=m Evidence for G protein modulation of experimental-generalized absence seizures in rat. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1302268&form=6&db=m Mechanism of release of Ca2+ from intracellular stores in response to ionomycin in oocytes of the frog Xenopus laevis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1303165&form=6&db=m GTP-binding proteins in bovine brain nuclear membranes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1306522&form=6&db=m D2 dopaminergic receptors: normal and abnormal transduction mechanisms. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1309239&form=6&db=m The epithelial phenotype of human neuroblastoma cells express bradykinin, endothelin, and angiotensin II receptors that stimulate phosphoinositide hydrolysis. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1309343&form=6&db=m Identification and functional characterization of adenylate cyclase-linked receptors for parathyroid hormone-like peptides on immortalized human keratinocytes. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1309445&form=6&db=m Myocardial beta-adrenergic receptor expression and signal transduction after chronic volume-overload hypertrophy and circulatory congestion. causal interaction,diagnostic usage,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1309512&form=6&db=m Pertussis toxin partially inhibits phagocytosis of immunoglobulin G-opsonized Staphylococcus aureus by human granulocytes but does not affect intracellular killing. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1309558&form=6&db=m The binding subunit of pertussis toxin inhibits IL-1 induction of IL-2 and prostaglandin production. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1309574&form=6&db=m Cellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1309696&form=6&db=m Incomplete functional differentiation of HL-60 leukemic cells by synthetic lipopeptides. Partial inhibition by pertussis toxin of enhanced superoxide formation. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1309821&form=6&db=m Receptor-mediated autocrine growth-stimulatory effect of 5-hydroxytryptamine on cultured human pancreatic carcinoid cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1309880&form=6&db=m Effects of the amphiphilic peptides melittin and mastoparan on calcium influx, phosphoinositide breakdown and arachidonic acid release in rat pheochromocytoma PC12 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1310010&form=6&db=m Dual regulation of cyclic AMP formation by thrombin in HEL cells, a leukaemic cell line with megakaryocytic properties. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1310139&form=6&db=m Angiotensin II receptor recognized by DuP753 regulates two distinct guanine nucleotide-binding protein signaling pathways. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1310140&form=6&db=m Carbachol-induced decrease in thyroid cell adenylyl cyclase activity is independent of calcium and phosphodiesterase activation. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1310399&form=6&db=m Extracellular ATP stimulates increases in Na+/K+ pump activity, intracellular pH and uridine uptake in cultures of mammalian cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1310589&form=6&db=m Receptor-mediated increases in cytosolic Ca2+ in the human erythroleukaemia cell line involve pertussis toxin-sensitive and -insensitive pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1310601&form=6&db=m A comparative study of endothelin- and platelet-activating-factor-mediated signal transduction and prostaglandin synthesis in rat Kupffer cells. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311221&form=6&db=m P2-purinoceptor activation stimulates phosphoinositide hydrolysis and inhibits accumulation of cAMP in cultured ventricular myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311240&form=6&db=m Isolation and mode of action of rabbit corticostatic (antiadrenocorticotropin) peptides. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311282&form=6&db=m Cholera toxin inhibits interleukin-2-induced, but enhances pertussis toxin-induced T-cell proliferation: regulation by cyclic nucleotides. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311319&form=6&db=m Purified epithelial Na+ channel complex contains the pertussis toxin-sensitive G alpha i-3 protein. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311408&form=6&db=m Platelet-activating factor stimulates phosphoinositide turnover in neurohybrid NCB-20 cells: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins and inhibition by protein kinase C. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311426&form=6&db=m Isoprenaline-induced increase in the 40/41 kDa pertussis toxin substrates and functional consequences on contractile response in rat heart. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311526&form=6&db=m Cholinergic stimulation of phosphoinositide metabolism in isolated rat glomeruli. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311671&form=6&db=m The effects of amylin on insulin secretion from Rin m5F cells and glycogen synthesis and lipogenesis in rat primary cultured hepatocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311686&form=6&db=m Effects of Ro 5-4864 and PK 11195 in rat duodenum and vas deferens. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311718&form=6&db=m Adenosine regulates a chloride channel via protein kinase C and a G protein in a rabbit cortical collecting duct cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311744&form=6&db=m Anomalous features of human neutrophil activation by influenza A virus are shared by related viruses and sialic acid-binding lectins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311807&form=6&db=m Pharmacological characterization of regulation of phosphoinositide metabolism by recombinant 5-HT2 receptors of the rat. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311819&form=6&db=m Adenosine-dependent enhancement by methylxanthines of excitatory synaptic transmission in hippocampus of rats. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1312133&form=6&db=m Pharmacological characterization of endothelin-stimulated phosphoinositide breakdown and cytosolic free Ca2+ rise in rat C6 glioma cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1312218&form=6&db=m Cyclic AMP differentiates two separate but interacting pathways of phosphoinositide hydrolysis in the DDT1-MF2 smooth muscle cell line. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1312225&form=6&db=m Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1312307&form=6&db=m Insoluble immune complex-stimulated neutrophil leukotriene B4 production is dependent on Fc gamma RII and Fc gamma RIII and independent of pertussis toxin-sensitive signal transduction pathways. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1312328&form=6&db=m Activation of human neutrophils by mastoparan. Reorganization of the cytoskeleton, formation of phosphatidylinositol 3,4,5-trisphosphate, secretion up-regulation of complement receptor type 3 and superoxide anion production are stimulated by mastoparan. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1312332&form=6&db=m Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1312437&form=6&db=m Endothelin-1 suppression of rat adipocyte precursor cell differentiation in serum-free culture. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1312448&form=6&db=m Melatonin signal transduction and mechanism of action in the central nervous system: using the rabbit cortex as a model. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1312511&form=6&db=m Signal transduction during antibody-dependent cellular cytotoxicity mediated by U937 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1312775&form=6&db=m Hypoxia-induced increased permeability of endothelial monolayers occurs through lowering of cellular cAMP levels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1312795&form=6&db=m Action of alpha 2A-adrenergic receptors in circular smooth muscle of canine proximal colon. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1312848&form=6&db=m Differential G protein-mediated coupling of D2 dopamine receptors to K+ and Ca2+ currents in rat anterior pituitary cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1313169&form=6&db=m Inhibition of L-type calcium channels by internal GTP [gamma S] in mouse pancreatic beta cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1313295&form=6&db=m Direct relationship between intracellular calcium mobilization and phospholipase D activation in prostaglandin E-stimulated human erythroleukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1313575&form=6&db=m Interaction of the pertussis toxin peptide containing residues 30-42 with DR1 and the T-cell receptors of 12 human T-cell clones. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1313776&form=6&db=m [Signal transduction of prostaglandin E2 and thromboxane A2] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1314279&form=6&db=m Regulation of pinocytosis in murine macrophages by colony-stimulating factors and other agents. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1314494&form=6&db=m NPY-stimulated Ca2+ mobilization in SK-N-MC cells is enhanced after isoproterenol treatment. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1314571&form=6&db=m Differential regulation of cAMP by endogenous versus transfected formylpeptide chemoattractant receptors: implications for Gi-coupled receptor signaling. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1314623&form=6&db=m Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1314714&form=6&db=m Specific receptor-guanine nucleotide binding protein interaction mediates the release of endothelium-derived relaxing factor. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1314958&form=6&db=m Ca2+ mobilization by the LH receptor expressed in Xenopus oocytes independent of 3',5'-cyclic adenosine monophosphate formation: evidence for parallel activation of two signaling pathways. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1315042&form=6&db=m Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1315052&form=6&db=m Coupling of a purified goldfish brain kainate receptor with a pertussis toxin-sensitive G protein. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1315147&form=6&db=m Cholera and pertussis toxins modify regulation of glucose transport activity in rat adipose cells: evidence for mediation of a cAMP-independent process by G-proteins. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1315505&form=6&db=m Stimulation of macrophage colony-stimulating factor synthesis by interleukin-1. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1315680&form=6&db=m Cyclic guanosine monophosphate analogs do not reverse bacterial toxin modulation of lactogen-stimulated NB2 cell mitogenesis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1315720&form=6&db=m Regulation of carbachol- and histamine-induced inositol phospholipid hydrolysis in a human oligodendroglioma. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1315788&form=6&db=m Ligand-induced formation of the leukotriene B4 receptor-G protein complex of human polymorphonuclear leukocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1316218&form=6&db=m Prostaglandin E2 receptors in the heart are coupled to inhibition of adenylyl cyclase via a pertussis toxin sensitive G protein. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1316904&form=6&db=m Endothelin inhibits adenylate cyclase and stimulates phosphoinositide hydrolysis in adult cardiac myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1316924&form=6&db=m Relationship between increased cyclic AMP-phosphodiesterase activity and abnormal adenylyl cyclase regulation in leukocytes from patients with atopic dermatitis. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1317000&form=6&db=m Identification of three separate guanine nucleotide-binding proteins that interact with the delta-opioid receptor in NG108-15 neuroblastoma x glioma hybrid cells. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1317042&form=6&db=m Muscarinic receptors, phosphoinositide metabolism and intracellular calcium in neuronal cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1317069&form=6&db=m N-methyl-N'-nitro-N-nitrosoguanidine: the effect on migration and cGMP level of neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1317174&form=6&db=m Biosynthesis of paf-acether in cultured-mouse mast cells: the role of calcium and G proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1317441&form=6&db=m Histamine H3-receptor activation augments voltage-dependent Ca2+ current via GTP hydrolysis in rabbit saphenous artery. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1317478&form=6&db=m Regulation of atrial natriuretic peptide-stimulated cGMP production in the inner medulla. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1317654&form=6&db=m Adenosine receptor-induced cAMP changes in D384 astrocytoma cells and the effect of bradykinin thereon. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1317777&form=6&db=m A comparison of the effects of concanavalin-A and tetradecanoylphorbol acetate on the modulation of parathyroid function by extracellular calcium and neomycin in dispersed bovine parathyroid cells. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1317819&form=6&db=m [Effects of lithium and antidepressants on monoaminergic receptors and receptor-coupled adenylate cyclase system in rat brain] diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1318029&form=6&db=m Activation of G proteins by (Rp) and (Sp) diastereomers of guanosine 5'-[beta-thio]triphosphate in hamster fibroblasts. Differential stereospecificity of Gi, Gs and Gp. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1318209&form=6&db=m Pertussis toxin induces bronchopulmonary hyperresponsiveness in guinea-pigs while antagonizing the effects of formyl-L-methionyl-L-leucyl-L-phenylalanine. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1318335&form=6&db=m Signal transduction mechanisms of C1q-mediated superoxide production. Evidence for the involvement of temporally distinct staurosporine-insensitive and sensitive pathways. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1318372&form=6&db=m Inhibition by 5-hydroxytryptamine of the beta adrenoceptor-mediated positive inotropic responses to catecholamines in rabbit papillary muscles: direct interaction with beta adrenoceptors. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1318516&form=6&db=m Mediation of serotonin hyperalgesia by the cAMP second messenger system. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1318547&form=6&db=m Proliferative effect of PGD2 on osteoblast-like cells; independent activation of pertussis toxin-sensitive GTP-binding protein from PGE2 or PGF2 alpha. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1318840&form=6&db=m Protein-tyrosine phosphorylations induced by concanavalin A and N-formyl-methionyl-leucyl-phenylalanine in human neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1318954&form=6&db=m L-AP4 inhibits calcium currents and synaptic transmission via a G-protein-coupled glutamate receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1318989&form=6&db=m Further characterization of alpha N-acetyl beta-endorphin-(1-31) regulatory activity, I: Effect on opioid- and alpha 2-mediated supraspinal antinociception in mice. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1319056&form=6&db=m Role of protein kinase C and transcription factor AP-1 in the acid-induced increase in Na/H antiporter activity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1319407&form=6&db=m Propionate induces polymorphonuclear leukocyte activation and inhibits formylmethionyl-leucyl-phenylalanine-stimulated activation. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1319454&form=6&db=m Release of interleukin-6 by human thyroid epithelial cells immortalized by simian virus 40 DNA transfection. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1319465&form=6&db=m In vivo evidence that lithium inactivates Gi modulation of adenylate cyclase in brain. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1319521&form=6&db=m In vitro formation and expansion of cysts derived from human renal cortex epithelial cells. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1319725&form=6&db=m Autocrine biological effects of glycosyl inositol phosphate produced by reconstituted pig thyroid follicles: role of pertussis toxin sensitive G proteins. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1319997&form=6&db=m Coupling of two endothelin receptor subtypes to differing signal transduction in transfected Chinese hamster ovary cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1320018&form=6&db=m Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1320248&form=6&db=m Angiotensin II and acetylcholine differentially activate mobilization of inositol phosphates in Xenopus laevis ovarian follicles. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1320457&form=6&db=m L-glutamate and acetylcholine mobilise Ca2+ from the same intracellular pool in cerebellar granule cells using transduction mechanisms with different Ca2+ sensitivities. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1320624&form=6&db=m Expression of functional Y1 receptors for neuropeptide Y in human Ewing's sarcoma cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1320658&form=6&db=m Modulation of meiotic arrest in mouse oocytes by guanyl nucleotides and modifiers of G-proteins. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1320689&form=6&db=m Continuous intrathecal opioid treatment abolishes the regulatory effects of magnesium and guanine nucleotides on mu opioid receptor binding in rat spinal membranes. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1320749&form=6&db=m Modulation of growth cone calcium current is mediated by a PTX-sensitive G protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1320875&form=6&db=m Zinc hydroxide stimulates superoxide production by rat alveolar macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1321229&form=6&db=m G protein modulation of omega-conotoxin binding sites in neuroblastoma x glioma NG 108-15 hybrid cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1321574&form=6&db=m Opioid and cannabinoid receptor inhibition of adenylyl cyclase in brain. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1321603&form=6&db=m Pertussis toxin blocks activin A-induced production of inositol phosphates in rat hepatocytes. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322036&form=6&db=m Differential effects of cytokines on long-term mitogenic and secretory responses of fetal rat pancreatic beta-cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322051&form=6&db=m Superoxide responses of endothelial cells to C5a and TNF-alpha: divergent signal transduction pathways. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322274&form=6&db=m Dissociation of antiproliferative and antihormonal effects of the somatostatin analog octreotide on 7315b pituitary tumor cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322406&form=6&db=m Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322414&form=6&db=m IL-3 stimulated haemopoietic stem cell proliferation: evidence for G protein independent mitogenic signalling events. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322665&form=6&db=m Effects of cyclosporine A on cyclic AMP generation and GTP-binding proteins in isolated islets. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322709&form=6&db=m Platelet-activating factor-mediated synthesis of prostaglandins in rat Kupffer cells. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322890&form=6&db=m ATP and its metabolite adenosine act synergistically to mobilize intracellular calcium via the formation of inositol 1,4,5-trisphosphate in a smooth muscle cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322966&form=6&db=m Possible existence of two subsets of platelet-activating factor receptor to mediate polyphosphoinositide breakdown and calcium influx in neuroblastoma x glioma hybrid NG 108-15 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322969&form=6&db=m Evidence for the implication of phosphoinositol signal transduction in mu-opioid inhibition of DNA synthesis. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1323430&form=6&db=m Positive chronotropic responses induced by alpha 1-adrenergic stimulation of normal and "ischemic" Purkinje fibers have different receptor-effector coupling mechanisms. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1323474&form=6&db=m Differentiation of renal Na(+)-K(+)-ATPase in control and streptozotocin-induced diabetic mice by G-protein acting toxins and phorbol esters. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1323477&form=6&db=m Endothelin-elicited stimulation of phospholipase C is mediated by guanine nucleotide binding protein(s). ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1323480&form=6&db=m Trans-ACPD inhibits cAMP formation via a pertussis toxin-sensitive G-protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1323494&form=6&db=m Stimulation of rat pancreatic tumoral AR4-2J cell proliferation by pituitary adenylate cyclase-activating peptide. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1323831&form=6&db=m Stimulation of adenosine A1 receptors and bradykinin receptors, which act via different G proteins, synergistically raises inositol 1,4,5-trisphosphate and intracellular free calcium in DDT1 MF-2 smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1324064&form=6&db=m The effect of pertussis toxin on beta-adrenoceptor responses in isolated cardiac myocytes from noradrenaline-treated guinea-pigs and patients with cardiac failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1324094&form=6&db=m Differentiation of Neuro-2a neuroblastoma cells by an antibody to GM3 ganglioside. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1324441&form=6&db=m Protein kinase C activator phorbol 12, 13-dibutyrate inhibits platelet activating factor-stimulated Ca2+ mobilization and phosphoinositide turnover in neurohybrid NG108-15 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1324505&form=6&db=m Effect of tumor necrosis factor-alpha on the stimulus-coupled responses of neutrophils and their modulation by various inhibitors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1324804&form=6&db=m Autocrine motility factor and its receptor: role in cell locomotion and metastasis. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1325491&form=6&db=m Mechanism of action of maternal serum on the interleukin2 receptor expression. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1325668&form=6&db=m Staphylococcus albus-induced protein kinase C translocation in human neutrophils: the effect of opsonization, cytochalasin B, pertussis toxin, intra- and extracellular calcium, and R59022. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1325978&form=6&db=m Tumor necrosis factor and interleukin 1 inhibit parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by down-regulating parathyroid hormone receptors. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1326337&form=6&db=m [The role of a GTP-binding protein in coupling of a muscarinic cholinergic receptor and Na,K-ATPase in myocardial sarcolemma] causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1326343&form=6&db=m PAF receptors and G-proteins in human blood eosinophils and neutrophils. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1326477&form=6&db=m Effects of pertussis toxin treatment on human natural killer cell function. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1326545&form=6&db=m Interaction of the frog brain kainate receptor expressed in Chinese hamster ovary cells with a GTP-binding protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1326620&form=6&db=m Epileptogenesis reduces the sensitivity of presynaptic gamma-aminobutyric acidB receptors on glutamatergic afferents in the amygdala. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1326743&form=6&db=m Inhibition of voltage-dependent Ca2+ channels via alpha 2-adrenergic and opioid receptors in cultured bovine adrenal chromaffin cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1327681&form=6&db=m Regulation of phosphoinositide and phosphatidylcholine phospholipases by G proteins. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1327719&form=6&db=m Forskolin-induced homologous desensitization via an adenosine 3',5'-monophosphate-dependent mechanism(s) in human osteoblast-like SaOS-2 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1328213&form=6&db=m The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1328241&form=6&db=m Responses of pertussis toxin-treated microvascular endothelial cells to transforming growth factor beta 1. No evidence for pertussis-sensitive G-protein involvement in TGF-beta signal transduction. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1328249&form=6&db=m Type IV collagen stimulates an increase in intracellular calcium. Potential role in tumor cell motility. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1328300&form=6&db=m Endothelin inhibits vasopressin-stimulated water permeability in rat terminal inner medullary collecting duct. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1328614&form=6&db=m Effects of beta-endorphin on mu and delta opioid receptor-coupled G-protein activity: low-Km GTPase studies. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1328619&form=6&db=m Comparison of the actions of baclofen at pre- and postsynaptic receptors in the rat hippocampus in vitro. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1329113&form=6&db=m Mechanism of prostaglandin E2-induced arachidonic acid release in osteoblast-like cells: independence from phosphoinositide hydrolysis. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1329538&form=6&db=m Chronic coronary arterial stenosis impairs alpha 1-adrenoreceptor signaling and cardiac performance in rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1329542&form=6&db=m Effects of angiotensin II and nonpeptide receptor antagonists on transduction pathways in rat proximal tubule. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1329580&form=6&db=m Intrathecal pertussis toxin treatment attenuates opioid antinociception and reduces high-affinity state of opioid receptors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1329739&form=6&db=m Two different signal transductions of neuropeptide Y1 receptor in SK-N-MC cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1329904&form=6&db=m Prolonged activation of inhibitory somatostatin receptors increases adenylate cyclase activity in wild-type and Gs alpha-deficient (cyc-) S49 mouse lymphoma cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1330052&form=6&db=m Insulin-dependent release of 5'-nucleotidase and alkaline phosphatase from liver plasma membranes. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1330092&form=6&db=m Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1330161&form=6&db=m Activation of the human neutrophil 5-lipoxygenase by leukotriene B4. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1330178&form=6&db=m A pertussis toxin-sensitive mechanism of endothelin action in porcine coronary artery smooth muscle. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1330216&form=6&db=m F11 neuroblastoma x DRG neuron hybrid cells express inhibitory mu- and delta-opioid receptors which increase voltage-dependent K+ currents upon activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1330496&form=6&db=m Angiotensin II potentiates agonist-induced 3',5'-cyclic adenosine monophosphate production by cultured bovine adrenal cells through protein kinase C and calmodulin pathways. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1330603&form=6&db=m Adrenergic inhibition of insulin secretion involves pertussis toxin-sensitive and -insensitive mechanisms. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1330644&form=6&db=m Polyphosphoinositide hydrolysis and protein kinase C activation in guinea pig tracheal smooth muscle cells in culture by leukotriene D4 involve a pertussis toxin sensitive G-protein. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1330658&form=6&db=m Induction of c-jun independent of PKC, pertussis toxin-sensitive G protein, and polyamines in quiescent SV40-transformed 3T3 T cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331068&form=6&db=m Regulatory effects of platelet-derived growth factor-AA homodimer on migration of vascular smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331088&form=6&db=m A protein kinase C inhibitor, staurosporine, activates phospholipase D via a pertussis toxin-sensitive GTP-binding protein in rabbit peritoneal neutrophils. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331094&form=6&db=m 15-Hydroxyeicosatetraenoic acid (15-HETE) receptors. Involvement in the 15-HETE-induced stimulation of the cryptic 5-lipoxygenase in PT-18 mast/basophil cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331121&form=6&db=m Platelet-activating factor stimulates multiple signaling pathways in cultured rat mesangial cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331276&form=6&db=m Different guanosine triphosphate-binding proteins couple vasopressin receptor to phospholipase C and phospholipase A2 in glomerular mesangial cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331329&form=6&db=m Differential sensitivity of the short and long human dopamine D2 receptor subtypes to protein kinase C. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331361&form=6&db=m Pharmacological and immunocytochemical characterization of metabotropic glutamate receptors in cultured Purkinje cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331412&form=6&db=m Potentiation of cyclic adenosine monophosphate production by thrombin in the human erythroleukemia cell line, HEL. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331689&form=6&db=m Phospholipase C activation by neurotensin and neuromedin N in Chinese hamster ovary cells expressing the rat neurotensin receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331735&form=6&db=m Adrenergic receptors coupled to adenylate cyclase in human cerebromicrovascular endothelium. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331760&form=6&db=m Long term beta-adrenoceptor-mediated up-regulation of Gi alpha and G(o) alpha mRNA levels and pertussis toxin-sensitive guanine nucleotide-binding proteins in rat heart. causal interaction,diagnostic usage,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331765&form=6&db=m Modulation of cardiac cyclic AMP metabolism by adenosine receptor agonists and antagonists. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331918&form=6&db=m Organophosphate-induced alterations in muscarinic receptor binding and phosphoinositide hydrolysis in the human SK-N-SH cell line. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331978&form=6&db=m Voltage-dependent noradrenergic modulation of omega-conotoxin-sensitive Ca2+ channels in human neuroblastoma IMR32 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1332512&form=6&db=m Endothelin stimulates multiple responses in isolated adult ventricular cardiac myocytes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1332754&form=6&db=m C3a receptor on dibutyryl-cAMP-differentiated U937 cells and human neutrophils: the human C3a receptor characterized by functional responses and 125I-C3a binding. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1332951&form=6&db=m A truncated recombinant alpha subunit of Gi3 with a reduced affinity for beta gamma dimers and altered guanosine 5'-3-O-(thio)triphosphate binding. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1333052&form=6&db=m Thyrotropin-releasing hormone and gonadotropin-releasing hormone receptors activate phospholipase C by coupling to the guanosine triphosphate-binding proteins Gq and G11. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1333103&form=6&db=m Pertussis toxin sensitive G-protein coupling of HDL receptor to phospholipase C in human platelets. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1333362&form=6&db=m Re-expression of alpha skeletal actin and regulation of alpha 1 adrenoceptor signalling in DOCA-salt hypertension in rats. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1333990&form=6&db=m Thrombin-induced proliferation and expression of platelet-derived growth factor-A chain gene in human vascular smooth muscle cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1334091&form=6&db=m Purification of a histamine H3 receptor negatively coupled to phosphoinositide turnover in the human gastric cell line HGT1. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1334227&form=6&db=m Regulation of renal epithelial sodium channels. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1334410&form=6&db=m Characterization of noradrenaline-stimulated cyclic GMP formation in brain astrocytes in culture. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1334747&form=6&db=m Guinea-pig treatment with pertussis toxin suppresses macrophage-dependent bronchoconstriction by fMLP and fails to inhibit the effects of PAF. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1334751&form=6&db=m Bradykinin-induced activation of nociceptors: receptor and mechanistic studies on the neonatal rat spinal cord-tail preparation in vitro. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1334775&form=6&db=m Neuropeptide Y inhibits alpha-MSH release from rat hypothalamic slices through a pertussis toxin-sensitive G protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1334992&form=6&db=m Role of altered G-protein expression in the regulation of myocardial adenylate cyclase activity and force of contraction in spontaneous hypertensive cardiomyopathy in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1335068&form=6&db=m Neuropeptide Y inhibits forskolin-stimulated adenylate cyclase in bovine adrenal chromaffin cells via a pertussis toxin-sensitive process. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1335071&form=6&db=m Comparison of signal transduction mechanisms of alpha-2C and alpha-1A adrenergic receptor-stimulated prostaglandin synthesis. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1335135&form=6&db=m Vasoactive intestinal peptide is a secretagogue in bovine chromaffin cells pretreated with pertussis toxin. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1335253&form=6&db=m Prostaglandin E2-induced arachidonic acid release and catecholamine secretion from cultured bovine adrenal chromaffin cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1335333&form=6&db=m Characterization of adenosine receptors in brush-border membranes from pig kidney. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1335416&form=6&db=m Affinity cross-linked delta-opioid receptor in NG108-15 cells is low molecular weight (25 kDa) and coupled to GTP-binding proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1335563&form=6&db=m An N-ethylmaleimide-sensitive G-protein modulates Aplysia Ca2+ channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1335688&form=6&db=m PGE2 regulates cAMP production in cultured rabbit CCD cells: evidence for dual inhibitory mechanisms. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1335690&form=6&db=m Muscarinic receptors in MDCK cells are coupled to multiple messenger systems. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1335731&form=6&db=m Enhancement of differentiation of cultured adipogenic cells (TA1) by pertussis toxin. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1335766&form=6&db=m A novel hypothalamic peptide, pituitary adenylate cyclase activating peptide, modulates Sertoli cell function in vitro. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1336223&form=6&db=m Serotonergic signalling between thyroid cells: protein kinase C and 5-HT2 receptors in the secretion and action of serotonin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1336300&form=6&db=m Protein kinase C modulates parathyroid hormone- but not prostaglandin E2-mediated stimulation of cyclic AMP production via the inhibitory guanine nucleotide binding protein in UMR-106 osteosarcoma cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1336310&form=6&db=m DOCA-enhanced sites of vasopressin-stimulated cAMP formation in rat cortical collecting tubule. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1336550&form=6&db=m Pipette GTP is essential for receptor-mediated regulation of Cl- current in dialysed myocytes from guinea-pig ventricle. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1336572&form=6&db=m Pertussis toxin inhibits noradrenaline accumulation by bovine adrenal medullary chromaffin cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1336712&form=6&db=m Increase in functional activity rather than in amount of Gi-alpha in failing human heart with dilated cardiomyopathy. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1336751&form=6&db=m On the mechanism of the interaction of ketamine and halothane in vitro. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1336968&form=6&db=m Inhibition of oxytocin-stimulated phosphoinositide turnover in rat myometrium by pertussis and cholera toxins may involve protein kinase A activation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1337013&form=6&db=m Bradykinin binding to B2 kinin receptors and stimulation of phosphoinositide turnover and arachidonic acid release in primary cultures of cells from late pregnant rat myometrium. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1338306&form=6&db=m Pharmacological characterization of alpha 2-adrenoceptors in isolated jejunum of rabbits. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1338652&form=6&db=m Enkephalin induces Ca2+ mobilization in single cells of bradykinin-sensitized differentiated neuroblastoma hybridoma (NG108-15) cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1338790&form=6&db=m Prostaglandin modulation of Ca2+ channels in rat sympathetic neurones is mediated by guanine nucleotide binding proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1338944&form=6&db=m Regulation of bradykinin-induced phosphoinositide turnover in cultured cerebellar astrocytes: possible role of protein kinase C. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1343598&form=6&db=m Carbachol-stimulated calcium entry in SH-SY5Y human neuroblastoma cells: which route? unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1346090&form=6&db=m Pertussis toxin and voltage dependence distinguish multiple pathways modulating calcium channels of rat sympathetic neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1346166&form=6&db=m The insulin-secreting cell line, RINm5F, expresses an alpha-2D adrenoceptor and nonadrenergic idazoxan-binding sites. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1346168&form=6&db=m Comparison of mu opioid receptor binding on intact neuroblastoma cells with guinea pig brain and neuroblastoma cell membranes. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1346392&form=6&db=m Alpha 2-C10 adrenergic receptors expressed in rat 1 fibroblasts can regulate both adenylylcyclase and phospholipase D-mediated hydrolysis of phosphatidylcholine by interacting with pertussis toxin-sensitive guanine nucleotide-binding proteins. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1346400&form=6&db=m TGF-beta-induced G2/M delay in proliferating rabbit articular chondrocytes is associated with an enhancement of replication rate and a cAMP decrease: possible involvement of pertussis toxin-sensitive pathway. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1346627&form=6&db=m Pertussis toxin in the A10 region increases dopamine synthesis and metabolism. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1346640&form=6&db=m Neuromodulatory effects of atrial natriuretic peptides correlate with an inhibition of adenylate cyclase but not an activation of guanylate cyclase. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1346876&form=6&db=m Immunogenicity of combined diphtheria, tetanus, and pertussis vaccine given at 2, 3, and 4 months versus 3, 5, and 9 months of age. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1347051&form=6&db=m Pertussis toxin-induced lymphocytosis is associated with alterations in thymocyte subpopulations. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1347200&form=6&db=m Alpha 1-adrenergic signaling in human airway epithelial cells involves inositol lipid and phosphate metabolism. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1347957&form=6&db=m Gz-mediated hormonal inhibition of cyclic AMP accumulation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1347975&form=6&db=m Actions of somatostatins on gastric smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1348116&form=6&db=m The glutamate-receptor linked cGMP cascade of retinal on-bipolar cells is pertussis and cholera toxin-sensitive. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1348273&form=6&db=m 2-Chloroadenosine potentiates the alpha 1-adrenergic activation of phospholipase C through a mechanism involving arachidonic acid and glutamate in striatal astrocytes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1348400&form=6&db=m Mechanisms of signal transduction for adenosine and ATP in pulmonary vascular bed. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1348905&form=6&db=m Pertussis toxin-sensitive and pertussis toxin-insensitive inhibition of parietal cell response to GLP-1 and histamine. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1348908&form=6&db=m Calcitonin gene-related peptide: mechanisms of modulation of antral endocrine cells and cholinergic neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1348951&form=6&db=m Inhibition of the omega-conotoxin-sensitive calcium current by distinct G proteins. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1348983&form=6&db=m Synergism in cytosolic Ca2+ mobilization between bradykinin and agonists for pertussis toxin-sensitive G-protein-coupled receptors in NG 108-15 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1349229&form=6&db=m Inhibition of Ca(2+)-induced calcitonin secretion by somatostatin: roles of voltage dependent Ca2+ channels and G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1349606&form=6&db=m Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. I. Coupling of alpha 2-adrenergic receptor subtypes to distinct G-proteins. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1349890&form=6&db=m Activation of alpha 1- and alpha 2-adrenoceptors inhibits noradrenaline release in rabbit renal arteries: effects of pertussis toxin and N-ethylmaleimide. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1350105&form=6&db=m Pertussis toxin non-sensitive G protein mediates cholinergic stimulation for secretion of pancreastatin and somatostatin from QGP-1N cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1350336&form=6&db=m Reversal by pertussis toxin and N-ethylmaleimide of the facilitation of baroreceptor reflex response by somatostatin in the rat. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1350357&form=6&db=m Somatostatin inhibition of gastrin gene expression: involvement of pertussis toxin-sensitive and -insensitive pathways. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1350637&form=6&db=m Voltage- and time-dependent inhibition of neuronal calcium channels by a GTP-binding protein in a mammalian cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1351733&form=6&db=m Inhibition of quantal transmitter release in the absence of calcium influx by a G protein-linked adenosine receptor at hippocampal synapses. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1352551&form=6&db=m Central effects of quinpirole on blood pressure of spontaneously hypertensive rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1352768&form=6&db=m Proteolytic processing of the mosquitocidal toxin from Bacillus sphaericus SSII-1. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1352819&form=6&db=m Supersensitivity of isolated atria from diabetic rats to adenosine and methacholine: modulation by pertussis toxin. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1352869&form=6&db=m Adenosine inhibits the synaptic potentials in rat septal nucleus neurons mediated through pre- and postsynaptic A1-adenosine receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1352875&form=6&db=m Dual regulation of human syncytial adenylyl cyclase. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1353250&form=6&db=m Pharmacological properties of two cloned somatostatin receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1353482&form=6&db=m Role of carbohydrate recognition domains of pertussis toxin in adherence of Bordetella pertussis to human macrophages. causal interaction,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1353495&form=6&db=m Inhibition by glucagon of the cGMP-inhibited low-Km cAMP phosphodiesterase in heart is mediated by a pertussis toxin-sensitive G-protein. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1353790&form=6&db=m Glutamate inhibits adenylate cyclase activity in dispersed rat hippocampal cells directly via an N-methyl-D-aspartate-like metabotropic receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1354343&form=6&db=m Pertussis toxin pretreatment abolishes the inhibitory effect of riluzole and carbachol on D-[3H]aspartate release from cultured cerebellar granule cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1354776&form=6&db=m Measurement of free cytosolic calcium in single cells: method and application. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1354983&form=6&db=m Pertussis toxin reverses prostaglandin E2- and somatostatin-induced inhibition of rat parietal cell H(+)-production. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1355052&form=6&db=m Inhibitory effect of somatostatin on cAMP accumulation and calcitonin secretion in C-cells: involvement of pertussis toxin-sensitive G-proteins. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1355255&form=6&db=m Stimulatory effects of quinpirole hydrochloride, D2-dopamine receptor agonist, at low concentrations on prolactin release in female rats in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1355603&form=6&db=m Characterization of a metabotropic glutamate receptor: direct negative coupling to adenylyl cyclase and involvement of a pertussis toxin-sensitive G protein. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1356232&form=6&db=m Distinct pathways for beta-adrenoceptor-induced up-regulation of muscarinic acetylcholine receptors and inhibitory G-protein alpha-subunits in chicken cardiomyocytes. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1356237&form=6&db=m Pertussis toxin abolishes the inhibition of Ca2+ currents and of noradrenaline release via alpha 2-adrenoceptors in chick sympathetic neurons. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1356248&form=6&db=m The effects of pertussis toxin on dopamine D2 and serotonin 5-HT1A autoreceptor-mediated inhibition of neurotransmitter synthesis: relationship to receptor reserve. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1356569&form=6&db=m Prejunctional alpha 2-adrenoceptors in mouse atria function through G-proteins which are sensitive to N-ethylmaleimide, but not pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1357163&form=6&db=m Calcium current modulation in frog sympathetic neurones: multiple neurotransmitters and G proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1357547&form=6&db=m Identification of a cis-regulatory element mediating somatostatin inhibition of epidermal growth factor-stimulated gastrin gene transcription. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1357666&form=6&db=m Somatostatin receptors are expressed by immature cerebellar granule cells: evidence for a direct inhibitory effect of somatostatin on neuroblast activity. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1357826&form=6&db=m Effect of somatostatin on adenylate cyclase activity in normal and neoplastic thyroid tissue. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1358245&form=6&db=m Immunoprecipitation of a pertussis toxin substrate of the G(o) family from rat islets of Langerhans. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1358389&form=6&db=m Investigations into neuropeptide Y-mediated presynaptic inhibition in cultured hippocampal neurones of the rat. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1358666&form=6&db=m Experimental autoimmune anterior uveitis (EAAU). II. Dose-dependent induction and adoptive transfer using a melanin-bound antigen of the retinal pigment epithelium. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1358886&form=6&db=m Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. III. Coupling of alpha 2-adrenergic receptor subtypes in a cell type-specific manner. causal interaction,ongoing research,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1358898&form=6&db=m Extracellular ATP and ADP stimulate proliferation of porcine aortic smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1359017&form=6&db=m Neuropeptide Y inhibits beta-adrenergic agonist- and vasoactive intestinal peptide-induced cyclic AMP accumulation in rat pinealocytes through pertussis toxin-sensitive G protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1359107&form=6&db=m Comparative effects of receptor inactivation, 17 beta-estradiol and pertussis toxin on dopaminergic inhibition of prolactin secretion in vitro. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1359194&form=6&db=m Mechanisms of somatostatin action in RINm5F cells in culture: preliminary evidence for possible altered G protein function. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1359613&form=6&db=m Somatostatin inhibition of phosphoinositides turnover in isolated rat acinar pancreatic cells: interaction with bombesin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1360008&form=6&db=m Dopaminergic inhibition of DNA synthesis in pituitary tumor cells is associated with phosphotyrosine phosphatase activity. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1360185&form=6&db=m Somatostatin inhibits the norepinephrine-activated calcium channels in rMTC 6-23 cells: possible involvement of a pertussis toxin-sensitive G-protein. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1360366&form=6&db=m A metabotropic L-glutamate receptor agonist: pharmacological difference between rat central neurones and crayfish neuromuscular junctions. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1361027&form=6&db=m Guanine nucleotide- and muscarinic agonist-dependent phosphoinositide metabolism in synaptoneurosomes from cerebral cortex of immature rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1361052&form=6&db=m Activation of alpha 1-adrenoceptors modulates the inwardly rectifying potassium currents of mammalian atrial myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1361188&form=6&db=m Dopamine D2 receptor stimulation of Na+/H+ exchange assessed by quantification of extracellular acidification. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1361725&form=6&db=m Somatostatin inhibits vasopressin-stimulated phosphoinositide hydrolysis and influx of extracellular calcium in clonal hamster beta (HIT) cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1361911&form=6&db=m Guinea pig hepatocyte alpha 1A-adrenoceptors: characterization, signal transduction and regulation. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1361912&form=6&db=m Idazoxan down-regulates beta-adrenoceptors on C6 glioma cells in vitro. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1362426&form=6&db=m Somatostatin acts via a pertussis toxin-sensitive mechanism on calcitonin secretion in C-cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1362614&form=6&db=m The effect of pertussis toxin treatment on alpha-1-adrenoceptor-mediated pressor responses in the pithed rat: dependence on agonist efficacy but not chemical class. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1362856&form=6&db=m Activation of phosphoinositide turnover and protein kinase C by neurotransmitters that modulate calcium channels in embryonic chick sensory neurons. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1366929&form=6&db=m Gene replacement in Bordetella pertussis by transformation with linear DNA. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1366987&form=6&db=m The effect of pH on the production of pertussis toxin by Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1367364&form=6&db=m Production of cell mass and pertussis toxin by Bordetella pertussis. causal interaction,diagnostic usage,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1370047&form=6&db=m Towards third-generation whooping cough vaccines. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1370274&form=6&db=m Roles of protein kinase C and G proteins in activation of murine resting B lymphocytes by endotoxin-associated protein. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1370436&form=6&db=m Biphasic effect of cAMP-elevating agents on ICAM-1 expression stimulated by retinoic acid and interferon gamma. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1371601&form=6&db=m Possible role of cGMP in excitatory amino acid induced cytotoxicity in cultured cerebral cortical neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1371645&form=6&db=m Perturbation of regulated secretion in the pancreatic acinar cell line, AR42J. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1371994&form=6&db=m Signal transduction by tumor necrosis factor alpha is mediated through a guanine nucleotide-binding protein in osteoblast-like cell line, MC3T3-E1. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1372085&form=6&db=m Activation of beta-adrenergic receptors inhibits Ca2+ entry-mediated generation of inositol phosphates in the guinea pig myometrium, a cyclic AMP-independent event. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1372167&form=6&db=m Natural polyamines stimulate G-proteins. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1373170&form=6&db=m A mechanism of action for anaphylatoxin C3a stimulation of mast cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1373177&form=6&db=m Properties of muscarinic-stimulated adenylate cyclase activity in rat olfactory bulb. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1374016&form=6&db=m Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I(7-37) in mouse insulinoma beta TC-1 cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1374961&form=6&db=m Activation and modulation of neuronal K+ channels by GABA. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1375958&form=6&db=m Role of GTP-binding proteins in the regulation of mammalian cardiac chloride conductance. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1376359&form=6&db=m Dual effects of endothelins -1, -2 and -3 on guinea pig field-stimulated ileum: possible mediation by two receptors coupled to pertussis toxin-insensitive mechanisms. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1376748&form=6&db=m Antigen receptor-mediated protein tyrosine kinase activity is regulated by a pertussis toxin-sensitive G protein. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1376819&form=6&db=m N-ethylmaleimide diminishes alpha 2-adrenoceptor-mediated effects on norepinephrine release in rat tail arteries. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1376885&form=6&db=m K+ channel involvement in induction of synaptic enhancement by mast cell degranulating (MCD) peptide. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1377126&form=6&db=m Angiotensin II receptor-mediated calcium influx in bovine adrenal glomerulosa cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1377629&form=6&db=m Modulation of hypothalamic norepinephrine release by atrial natriuretic peptide: involvement of cyclic GMP. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1378073&form=6&db=m RANTES, a monocyte and T lymphocyte chemotactic cytokine releases histamine from human basophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1378173&form=6&db=m Insulin releasing effects of mastoparan and amphiphilic substance P receptor antagonists on RINm5F insulinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1378444&form=6&db=m Cloning and characterization of a cDNA coding for the alpha-subunit of a stimulatory G protein from Schistosoma mansoni. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1378490&form=6&db=m Maitotoxin-induced intracellular calcium rise in PC12 cells: involvement of dihydropyridine-sensitive and omega-conotoxin-sensitive calcium channels and phosphoinositide breakdown. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1379246&form=6&db=m Direct activation of second messenger pathways mimics cell adhesion molecule-dependent neurite outgrowth. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1379345&form=6&db=m Antisense oligodeoxynucleotides to GS protein alpha-subunit sequence accelerate differentiation of fibroblasts to adipocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1379379&form=6&db=m Galanin inhibition of enteric cholinergic neurotransmission: guanosine triphosphate-binding protein interactions with adenylate cyclase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1379559&form=6&db=m Activation of voltage-dependent calcium channels of mammalian sperm is required for zona pellucida-induced acrosomal exocytosis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1380077&form=6&db=m Serum-induced sensitization of cyclic AMP accumulation in C62B rat glioma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1380512&form=6&db=m Role of protein kinase C in transforming growth factor-beta 1 induction of carcinoembryonic antigen in human colon carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1380808&form=6&db=m Serotonin stimulates a Ca2+ permeant nonspecific cation channel in hepatic endothelial cells. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1381043&form=6&db=m Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1381336&form=6&db=m Modulation of norepinephrine release by galanin in rat medulla oblongata. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1382598&form=6&db=m Regulation of phosphate transport by second messengers in capillaries of the blood-brain barrier. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1382809&form=6&db=m Effect of neurotransmitters on axoplasmic transport: acetylcholine effect on superior cervical ganglion cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1383145&form=6&db=m Identification of human T-cell epitopes on the S4 subunit of pertussis toxin. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1383153&form=6&db=m Identification of T- and B-cell epitopes of the S2 and S3 subunits of pertussis toxin by use of synthetic peptides. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1383321&form=6&db=m Activation of human basophils through the IL-8 receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1383494&form=6&db=m Characterization of [125I]acidic fibroblast growth factor binding to the cloned human fibroblast growth factor receptor, FGF-flg, on NIH 3T3 cell membranes: inhibitory effects of heparin, pertussis toxin and guanine nucleotides. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1383496&form=6&db=m Imipramine's selective suppression of an L-type calcium channel in neurons of murine dorsal root ganglia involves G proteins. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1383666&form=6&db=m Role of cAMP in the functional interaction of carbachol with different cAMP elevating agents in rabbit atrium. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1384602&form=6&db=m Recombinant acellular pertussis vaccine--from the laboratory to the clinic: improving the quality of the immune response. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1384997&form=6&db=m Removal of endotoxin from culture supernatant of Bordetella pertussis with aminated poly(gamma-methyl L-glutamate) spherical beads. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1386917&form=6&db=m Intracerebroventricularly administered pertussis toxin blocks the central vasopressor action of neuropeptide Y(13-36) in the awake unrestrained male rat. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1395512&form=6&db=m Characterization of a G-protein from the mandibular organ of the lobster Homarus americanus (Nephropidae, Decapoda). diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1396321&form=6&db=m Mechanisms of desensitization to parathyroid hormone in human osteoblast-like SaOS-2 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1397291&form=6&db=m Enzymatic and immunological detection of G protein alpha-subunits in the pathogenic fungus Candida albicans. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1397295&form=6&db=m Muscarinic acetylcholine receptor produced in recombinant baculovirus infected Sf9 insect cells couples with endogenous G-proteins to activate ion channels. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1398937&form=6&db=m Specific lung mucosal and systemic immune responses after oral immunization of mice with Salmonella typhimurium aroA, Salmonella typhi Ty21a, and invasive Escherichia coli expressing recombinant pertussis toxin S1 subunit. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1398968&form=6&db=m Proliferative responses and gamma interferon and tumor necrosis factor production by lymphocytes isolated from tracheobroncheal lymph nodes and spleen of mice aerosol infected with Bordetella pertussis. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1398970&form=6&db=m Uptake and intracellular survival of Bordetella pertussis in human macrophages. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1400011&form=6&db=m Endotoxin tolerance is associated with altered GTP-binding protein function. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1402020&form=6&db=m Recombinant interleukin-8 induces changes in cytosolic Ca2+ in human neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1402092&form=6&db=m [Protective activity of tea and catechins against Bordetella pertussis] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1402917&form=6&db=m Identification of G protein subtypes in peripheral nerve and cultured Schwann cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1403095&form=6&db=m Norepinephrine inhibits calcium currents and EPSPs via a G-protein-coupled mechanism in olfactory bulb neurons. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1403815&form=6&db=m Comparison of the actions of adenosine at pre- and postsynaptic receptors in the rat hippocampus in vitro. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1403848&form=6&db=m Comparison of second messenger formation in human keratinocytes following stimulation with epidermal growth factor and bradykinin. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1405334&form=6&db=m Cytokine regulation of adenylate cyclase activity in LLC-PK1 cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1407002&form=6&db=m Modulation by sigma ligands of N-methyl-D-aspartate-induced [3H]noradrenaline release in the rat hippocampus: G-protein dependency. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1415557&form=6&db=m Role of endothelin-1 in regulating proliferation of cultured rabbit airway smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1415569&form=6&db=m Angiotensin II receptor subtypes in cultured rat renal mesangial cells. diagnostic usage,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1415674&form=6&db=m Lysophosphatidic acid induces a pertussis toxin-sensitive Ca(2+)-activated Cl- current in Xenopus laevis oocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1418853&form=6&db=m Facilitatory effects of diltiazem on dopamine release in the central nervous system. Focus on interactions with D2 autoreceptors and guanosine triphosphate binding proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1419481&form=6&db=m Involvement of pertussis toxin-sensitive and -insensitive GTP-binding proteins in luteinizing hormone exocytosis distal to second messenger generation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1419484&form=6&db=m Microinjection of the alpha-subunit of the G protein Go2, but not Go1, reduces a voltage-sensitive calcium current. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1419487&form=6&db=m Granulocyte-macrophage colony-stimulating factor primes phospholipase D activity in human neutrophils in vitro: role of calcium, G-proteins and tyrosine kinases. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1425359&form=6&db=m A developmentally regulated switch in neuronal responsiveness to NCAM and N-cadherin in the rat hippocampus. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1425441&form=6&db=m Carbohydrate moiety of follitropin receptor is not required for high affinity hormone-binding or for functional coupling between receptor and guanine nucleotide-binding protein in bovine calf testis membranes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1425916&form=6&db=m Signal transduction for interleukin-3-dependent leukotriene synthesis in normal human basophils: opposing role of tyrosine kinase and protein kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1425983&form=6&db=m Effects of angiotensin II and angiotensin III on airway epithelial short-circuit current: involvement of pertussis toxin-sensitive G protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1426932&form=6&db=m Alterations of G protein function in cardiac tissues from streptozotocin-induced chronic diabetic rats. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1429369&form=6&db=m Phospholipids regulate growth and function of MDCK cells in hormonally defined serum free medium. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1429559&form=6&db=m The lymphoma transmembrane glycoprotein GP85 (CD44) is a novel guanine nucleotide-binding protein which regulates GP85 (CD44)-ankyrin interaction. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1429577&form=6&db=m Agonist-induced phosphorylation and desensitization of human m2 muscarinic cholinergic receptors in Sf9 insect cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1429842&form=6&db=m Calcium influx into neurons can solely account for cell contact-dependent neurite outgrowth stimulated by transfected L1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1431098&form=6&db=m Unidirectional, heterologous desensitization of the pertussis toxin receptor by the CD3/TCR complex. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1432705&form=6&db=m GTP-binding protein involvement in membrane currents evoked by carbachol and histamine in guinea-pig ileal muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1435749&form=6&db=m Epidermal growth factor activates phospholipase C in rat hepatocytes via a different mechanism from that in A431 or rat1hER cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1435750&form=6&db=m Peptide inhibitors of ADP-ribosylation by pertussis toxin are substrates with affinities comparable to those of the trimeric GTP-binding proteins. causal interaction,diagnostic usage,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1436039&form=6&db=m Lipid modification at the N terminus of photoreceptor G-protein alpha-subunit. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1443163&form=6&db=m Stretching increases calcium influx and efflux in cultured pulmonary arterial smooth muscle cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1445203&form=6&db=m Characterization of a Gi-protein from Trypanosoma cruzi epimastigote membranes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1445233&form=6&db=m Exocytosis in electropermeabilized neutrophils. Responsiveness to calcium and guanosine 5'-[gamma-thio]triphosphate. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1445250&form=6&db=m Mitogen-induced tyrosine phosphorylation of 41 kDa and 43 kDa proteins. Potential role in integrating multiple mitogenic signalling pathways. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1445283&form=6&db=m Enhanced expression of inhibitory guanine nucleotide regulatory protein in spontaneously hypertensive rats. Relationship to adenylate cyclase inhibition. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1445918&form=6&db=m Amino acid-specific ADP-ribosylation: structural characterization and chemical differentiation of ADP-ribose-cysteine adducts formed nonenzymatically and in a pertussis toxin-catalyzed reaction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1447947&form=6&db=m Intracerebroventricular injection of antibodies directed against Gs alpha enhances the supraspinal antinociception induced by morphine, beta-endorphin and clonidine in mice. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1447974&form=6&db=m Expression of bacterial cytotoxin genes in mammalian target cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1448178&form=6&db=m Functional expression of human 5-HT1A receptors and differential coupling to second messengers in CHO cells. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1449486&form=6&db=m Guanosine 5'-O-(3-thiotriphosphate) causes endothelium-dependent, pertussis toxin-sensitive relaxations in porcine coronary arteries. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1450395&form=6&db=m The purification of a guanine nucleotide regulatory protein from rat brain membrane and the measurement of its GTPase. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1451600&form=6&db=m Signal transduction in monocytes and granulocytes measured by multiparameter flow cytometry. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1451736&form=6&db=m Influence of pertussis toxin on thermic responses to morphine and neurotensin in rats. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1452339&form=6&db=m Construction of a diphtheria toxin A fragment-C180 peptide fusion protein which elicits a neutralizing antibody response against diphtheria toxin and pertussis toxin. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1452341&form=6&db=m Interaction of pertussis toxin with human T lymphocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1454136&form=6&db=m Genes coding for proteins in central nervous system myelin. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1459417&form=6&db=m Stimulation of neutrophil leukocyte chemotaxis by a cloned cytolytic enterotoxin of Aeromonas hydrophila. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1464309&form=6&db=m Multiple trimeric G-proteins on the trans-Golgi network exert stimulatory and inhibitory effects on secretory vesicle formation. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1464505&form=6&db=m Guanine nucleotide binding proteins in the dual regulation of lacrimal function. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1464609&form=6&db=m Phosphorylation-dependent regulation of phospholipase A2 by G-proteins and Ca2+ in HL60 granulocytes. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1464611&form=6&db=m Transforming growth factor-beta up-regulates low density lipoprotein receptor-mediated cholesterol metabolism in vascular smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1465133&form=6&db=m Isozyme-selective stimulation of phospholipase C-beta 2 by G protein beta gamma-subunits. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1465134&form=6&db=m Subunits beta gamma of heterotrimeric G protein activate beta 2 isoform of phospholipase C. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1471424&form=6&db=m Progress towards the development of new vaccines against whooping cough. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1473250&form=6&db=m Epigenetic activation of Gi-2 protein, the product of a putative protooncogene, mediates tumor promotion in vitro. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1473555&form=6&db=m Histamine activates phosphorylase and inositol phosphate production in guinea pig hepatocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1475013&form=6&db=m Angiotensin II is retained in gonadotrophs of pituitary cell aggregates cultured in serum-free medium but does not mimic the effects of exogenous angiotensins and luteinizing-hormone-releasing hormone on growth hormone release. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1477198&form=6&db=m Competition between zonae pellucidae and a proteinase inhibitor for sperm binding. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1480165&form=6&db=m Post-receptor defect accounts for phosphorylase hypersensitivity in cultured diabetic cardiomyocytes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1480512&form=6&db=m Gi protein mediates adenylate cyclase inhibition by neurohypophyseal hormones in fish gill. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1483383&form=6&db=m Expression and potential functions of G-protein alpha subunits in embryos of Xenopus laevis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1486937&form=6&db=m Thrombin stimulates inositol phosphate formation, intracellular calcium fluxes and DNA synthesis in cultured fetal human non-pigmented ciliary epithelial cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1486940&form=6&db=m Experimental autoimmune posterior uveitis accompanied by epitheloid cell accumulations (EAPU). A new type of experimental ocular disease induced by immunization with PEP-65, a pigment epithelial polypeptide preparation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1488103&form=6&db=m Mechanisms of norepinephrine mediated corticotropin-releasing factor-41 release from cultured fetal hypothalamic cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1488551&form=6&db=m Functional analysis of the pertussis toxin promoter. diagnostic usage,ongoing research,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1489833&form=6&db=m [Inhibiting effect of ADP-ribosylation by pertussis toxin on passive transport of Ca2+ into the cell membrane of porcine myometrium] ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1491429&form=6&db=m G-protein activators induce a potassium conductance in murine macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1493810&form=6&db=m Interleukin-1 is a motility factor for human breast carcinoma cells in vitro: additive effect with interleukin-6. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1497577&form=6&db=m Quantification of Gi alpha-proteins in the failing and nonfailing human myocardium. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1499560&form=6&db=m The primary structure of the alpha subunit of a starfish guanosine-nucleotide-binding regulatory protein involved in 1-methyladenine-induced oocyte maturation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1500160&form=6&db=m Synthesis of a conjugate vaccine composed of pneumococcus type 14 capsular polysaccharide bound to pertussis toxin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1505667&form=6&db=m Flow-induced prostacyclin production is mediated by a pertussis toxin-sensitive G protein. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1510880&form=6&db=m Prostaglandin E2 can bimodally inhibit and stimulate the epididymal adipocyte adenylyl cyclase activity. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1510959&form=6&db=m Pertussis toxin-catalyzed ADP-ribosylation of G(o) alpha with mutations at the carboxyl terminus. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1510988&form=6&db=m Differential isoprenylation of carboxy-terminal mutants of an inhibitory G-protein alpha-subunit: neither farnesylation nor geranylgeranylation is sufficient for membrane attachment. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1512271&form=6&db=m K-ras transformation greatly increases the toxin-dependent ADP-ribosylation of GTP binding proteins in thyroid cells. Involvement of an inhibitor of the ADP-ribosylation reaction. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1513927&form=6&db=m Mechanisms of cocaine-induced sensitization. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1515934&form=6&db=m Involvement of pertussis toxin sensitive G-proteins in conditioned fear-potentiated startle: possible involvement of the amygdala. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1516613&form=6&db=m Active lymphocyte traffic induced in the periphery by cytokines and phytohemagglutinin: three different mechanisms? therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1517577&form=6&db=m A threshold level of coupled G-proteins is required to transduce neutrophil responses. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1517818&form=6&db=m Isoproterenol enhances a calcium-independent potassium current in mouse anterior pituitary tumor cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1520970&form=6&db=m Pertussis whole cell vaccine: relation between intracerebral protection in mice and antibody response to pertussis toxin, filamentous hemagglutinin and adenylate cyclase. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1521562&form=6&db=m The involvement of products of the phospholipase pathway in the acute release of tissue-type plasminogen activator from perfused rat hindlegs. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1523873&form=6&db=m Multiple discontinuity as a remarkable feature of the development of acellular pertussis vaccines. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1527428&form=6&db=m The longevity of the immune response to filamentous hemagglutinin and pertussis toxin in patients with pertussis in a semiclosed community. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1527588&form=6&db=m The subcellular localization of the G-protein Gi alpha in the basal ganglia reveals its potential role in both signal transduction and vesicle trafficking. causal interaction,diagnostic usage,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1529762&form=6&db=m NPY-(18-36) and pertussis toxin distinguish between the negative and positive contractile effects of neuropeptide Y (NPY) in ventricular cardiomyocytes. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1530867&form=6&db=m Opiate-dependent changes in the sensitivity of adenylate cyclase to stimulatory agonists and 5'-guanylylimidodiphosphate are independent of G protein abundance and eukaryotic ADP-ribosyltransferase activity in NG108-15 cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1531307&form=6&db=m Functional expression of the macrophage colony-stimulating factor receptor in human THP-1 monocytic leukemia cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1531982&form=6&db=m Signal transduction by neutrophil immunoglobulin G Fc receptors. Dissociation of intracytoplasmic calcium concentration rise from inositol 1,4,5-trisphosphate. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1532149&form=6&db=m The glycosylphosphatidylinositol-linked Fc gamma receptor III represents the dominant receptor structure for immune complex activation of neutrophils. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1533239&form=6&db=m Effect of pertussis toxin on susceptibility of infant rats to Haemophilus influenzae type b. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1535517&form=6&db=m Role of receptor binding and gene transcription for both the stimulatory and inhibitory effects of interleukin-1 in pancreatic beta-cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1538709&form=6&db=m Heterogeneity of angiotensin II AT2 receptors in the rat brain. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1539113&form=6&db=m Participation of pertussis toxin-sensitive GTP-binding regulatory proteins in the suppression of baroreceptor reflex by neurotensin in the rat. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1539974&form=6&db=m Construction of Bordetella pertussis strains that overproduce genetically inactivated pertussis toxin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1540164&form=6&db=m Glucose regulates the expression of Gi-proteins in cultured BC3H-1 myocytes. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1541530&form=6&db=m Cellular pertussis vaccine containing a Bordetella pertussis strain that produces a nontoxic pertussis toxin molecule. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1541543&form=6&db=m Generation of human monoclonal antibodies that confer protection against pertussis toxin. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1544408&form=6&db=m Functional high efficiency expression of cloned leukocyte chemoattractant receptor cDNAs. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1544891&form=6&db=m A GTP-binding protein in rat liver nuclei serving as the specific substrate of pertussis toxin-catalyzed ADP-ribosylation. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1547891&form=6&db=m Probable occurrence of toxin-susceptible G proteins in the nematode Caenorhabditis elegans. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1548460&form=6&db=m Effect of pertussis toxin on radioligand binding to rat brain adenosine A1 receptors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1549178&form=6&db=m Action of brefeldin A blocked by activation of a pertussis-toxin-sensitive G protein. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1550214&form=6&db=m Triggering by ATP of product release by mucous granules of the land slug Ariolimax columbianus. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1550816&form=6&db=m Site-specific antibodies directed against G protein beta and gamma subunits: effects on alpha and beta gamma subunit interaction. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1551109&form=6&db=m Bombesin and glucocorticoids stimulate human breast cancer cells to produce endothelin, a paracrine mitogen for breast stromal cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1551200&form=6&db=m Adenosine-sensitive afterdepolarizations and triggered activity in guinea pig ventricular myocytes. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1551690&form=6&db=m Tumour necrosis factor-alpha stimulates invasiveness of T-cell hybridomas and cytotoxic T-cell clones by a pertussis toxin-insensitive mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1552653&form=6&db=m Effects of calcium-antagonists on dopamine release in the central nervous system--possible interactions with D2-autoreceptors and guanosine triphosphate-binding proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1554491&form=6&db=m Induction of polyclonal antibodies to the S1 subunit of pertussis toxin by synthetic peptides coupled to PPD: effect of conjugation method, adjuvant, priming and animal species. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1556134&form=6&db=m Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactions. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1557407&form=6&db=m Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1559973&form=6&db=m Thrombin-induced Ca2+ mobilization in vascular smooth muscle utilizes a slowly ribosylating pertussis toxin-sensitive G protein. Evidence for the involvement of a G protein in inositol trisphosphate-dependent Ca2+ release. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1560221&form=6&db=m Characterization of histamine-induced catecholamine secretion from bovine adrenal medullary chromaffin cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1560222&form=6&db=m Opioid signal transduction in intact and fragmented SH-SY5Y neural cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1562331&form=6&db=m A guanine nucleotide-binding regulatory protein in human sperm mediates acrosomal exocytosis induced by the human zona pellucida. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1564434&form=6&db=m Modification of the amounts of G proteins and of the activity of adenylyl cyclase in human benign thyroid tumours. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1566836&form=6&db=m Modulation of prostaglandin E2 synthesis in rat skeletal muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1569091&form=6&db=m Modification of chromaffin cells with pertussis toxin or N-ethylmaleimide lowers cytoskeletal F-actin and enhances Ca(2+)-dependent secretion. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1571163&form=6&db=m Activation of a G protein in mouse sperm by the zona pellucida, an egg-associated extracellular matrix. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1573265&form=6&db=m Mutations in the third, but not the first or second, hypervariable regions of DR(beta 1*0101) eliminate DR1-restricted recognition of a pertussis toxin peptide. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1573407&form=6&db=m Regulatory role of the GTP-binding protein, G(o), in the mechanism of exocytosis in adrenal chromaffin cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1573679&form=6&db=m Pertussis toxin provides evidence for two independent signalling pathways leading to the activation of the nerve growth factor gene. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1574919&form=6&db=m Characterization and detoxification of an easily prepared acellular pertussis vaccine. Antigenic role of the A protomer of pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1574921&form=6&db=m A simple and sensitive ELISA of antibodies to pertussis antigens. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1574959&form=6&db=m Maturation and insulin-like immunoreactivity in rat submandibular salivary glands: possible implication of G regulatory proteins. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1575694&form=6&db=m Staurosporine clamps cytosolic free Ca2+ concentrations of human neutrophils. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1577193&form=6&db=m Role of G proteins in mouse egg activation: stimulatory effects of acetylcholine on the ZP2 to ZP2f conversion and pronuclear formation in eggs expressing a functional m1 muscarinic receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1577804&form=6&db=m Sodium-dependent calcium efflux from adrenal chromaffin cells following exocytosis. Possible role of secretory vesicle membranes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1577868&form=6&db=m Ganglioside modulation of neural cell adhesion molecule and N-cadherin-dependent neurite outgrowth. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1578146&form=6&db=m IL-8 production by human polymorphonuclear leukocytes. The chemoattractant formyl-methionyl-leucyl-phenylalanine induces the gene expression and release of IL-8 through a pertussis toxin-sensitive pathway. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1578301&form=6&db=m Acellular pertussis vaccine composed of genetically inactivated pertussis toxin: safety and immunogenicity in 12- to 24- and 2- to 4-month-old children. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1579639&form=6&db=m The role of the nucleus accumbens in sensitization to drugs of abuse. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1587545&form=6&db=m Development and clinical testing of an acellular pertussis vaccine containing genetically detoxified pertussis toxin. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1587592&form=6&db=m Properties of pertussis toxin B oligomer assembled in vitro from recombinant polypeptides produced by Escherichia coli. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1588460&form=6&db=m Occurrence and biochemical characterization of GTP-binding proteins in Candida albicans. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1593352&form=6&db=m Serum antibodies against a 69-kilodalton outer-membrane protein, pertactin, from Bordetella pertussis in nonvaccinated children with and without a history of clinical pertussis. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1593486&form=6&db=m Endothelin activates voltage-dependent Ca2+ current by a G protein-dependent mechanism in rabbit cardiac myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1596516&form=6&db=m Arachidonic acid metabolism in isolated pancreatic islets. VI. Carbohydrate insulin secretagogues must be metabolized to induce eicosanoid release. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1596750&form=6&db=m Apomorphine- and oxytocin-induced penile erection and yawning in male rats: effect of pertussis toxin. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1597165&form=6&db=m The effects of extracellular calcium and epinephrine on cytosolic-free calcium in single rat adipocytes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1598071&form=6&db=m Quantitative determination of pertussis toxin-sensitive G proteins using [32P]ADP-ribosylation in human platelet membranes: negative correlation with ages. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1599416&form=6&db=m Exocytosis from permeabilized bovine adrenal chromaffin cells is differently modulated by guanosine 5'-[gamma-thio]triphosphate and guanosine 5'-[beta gamma-imido]triphosphate. Evidence for the involvement of various guanine nucleotide-binding proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1599449&form=6&db=m Two distinct pathways in the down-regulation of type-1 angiotension II receptor gene in rat glomerular mesangial cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1601642&form=6&db=m Tiopronin (2-mercaptopropionylglycine) has chemokinetic and chemotactic properties for polymorphonuclear leukocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1603083&form=6&db=m Conditional transformation mediated via a pertussis toxin-sensitive receptor signalling pathway. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1603090&form=6&db=m Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1610560&form=6&db=m Determination of antibodies to pertussis toxin in working reference preparations of anti-pertussis sera from various national control laboratories. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1612292&form=6&db=m Pertussis toxin and target eukaryotic cells: binding, entry, and activation. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1614333&form=6&db=m Both adenylate cyclase and hemolytic activities are required by Bordetella pertussis to initiate infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1617406&form=6&db=m The role of GTP binding proteins in ischemic brain damage: autoradiographic and histopathological study. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1618319&form=6&db=m GTP-binding proteins in luminal and basolateral membranes from pars convoluta and pars recta of rabbit kidney proximal tubule. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1618869&form=6&db=m Interaction of pertussis toxin with cells and model membranes. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1621656&form=6&db=m Clinical reactions and immunogenicity of the BIKEN acellular diphtheria and tetanus toxoids and pertussis vaccine in 4- through 6-year-old US children. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1624552&form=6&db=m Detection of antibodies inhibiting the ADP-ribosyltransferase activity of pertussis toxin in human serum. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1628210&form=6&db=m Correlation between behavioral sensitization to cocaine and G protein ADP-ribosylation in the ventral tegmental area. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1628499&form=6&db=m ADP-ribosylation of signal-transducing guanine nucleotide-binding proteins by pertussis toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1629205&form=6&db=m Activation of a Gi protein in mouse sperm membranes by solubilized proteins of the zona pellucida, the egg's extracellular matrix. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1632762&form=6&db=m Properties of 1-methyladenine receptors in starfish oocyte membranes: involvement of pertussis toxin-sensitive GTP-binding protein in the receptor-mediated signal transduction. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1635072&form=6&db=m Reduced adenylyl cyclase inhibition by carbachol and GTP during acute myocardial ischaemia. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1635279&form=6&db=m Characterization of G-proteins in rat glomeruli. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1636681&form=6&db=m Diverse prostaglandin receptors activate distinct signal transduction pathways in rat myometrium. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1636682&form=6&db=m Heat shock increases cytosolic free Ca2+ concentration via Na(+)-Ca2+ exchange in human epidermoid A 431 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1636684&form=6&db=m Activation of permeabilized neutrophils: role of anions. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1636738&form=6&db=m Hormonal regulation of rat renal proximal tubule brush-border membrane ionic permeability. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1636749&form=6&db=m Modulation of NO and endothelin by chronic increases in blood flow in canine femoral arteries. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1637337&form=6&db=m Evidence for G proteins in rat parotid plasma membranes and secretory granule membranes. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1640222&form=6&db=m On the mechanism of G protein beta gamma subunit activation of the muscarinic K+ channel in guinea pig atrial cell membrane. Comparison with the ATP-sensitive K+ channel. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1641126&form=6&db=m Pertussis toxin administration increases the expression of proneurotensin and preproenkephalin A mRNAs in rat striatum. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1643633&form=6&db=m Epidermal growth factor and transforming growth factor alpha stimulate or inhibit proliferation of a human renal adenocarcinoma cell line depending on cell status: differentiation of the two pathways by G protein involvement. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645259&form=6&db=m Dissociation of second messenger activation by parathyroid hormone fragments in osteosarcoma cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645260&form=6&db=m Neomycin mimics the effects of high extracellular calcium concentrations on parathyroid function in dispersed bovine parathyroid cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645263&form=6&db=m Regulation of guanine nucleotide binding regulatory proteins in cultured adrenal cells by adrenocorticotropin and angiotensin-II. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645335&form=6&db=m Identification of a botulinum C3-like enzyme in bovine brain that catalyzes ADP-ribosylation of GTP-binding proteins. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645346&form=6&db=m Cyclic AMP-dependent regulation of the number of [3H]batrachotoxinin benzoate binding sites on rat cardiac myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645524&form=6&db=m Insulin activates GTP binding to a 40 kDa protein in fat cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645747&form=6&db=m Prostaglandin E2 inhibits sodium transport in rabbit cortical collecting duct by increasing intracellular calcium. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645760&form=6&db=m Mechanism of neutrophil activation by an unopsonized inflammatory particulate. Monosodium urate crystals induce pertussis toxin-insensitive hydrolysis of phosphatidylinositol 4,5-bisphosphate. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645861&form=6&db=m GTP gamma S causes contraction of skinned frog skeletal muscle via the DHP-sensitive Ca2+ channels of sealed T-tubules. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1646032&form=6&db=m The effect of PGF2 alpha on parathyroid hormone-stimulated cyclic AMP production in mouse osteoblastic cell, MC3T3E1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1646318&form=6&db=m Endothelin- and sarafotoxin-induced phosphoinositide hydrolysis in cultured cerebellar granule cells: biochemical and pharmacological characterization. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1646330&form=6&db=m Ligand binding and functional characterization of muscarinic acetylcholine receptors on the TE671/RD human cell line. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1646651&form=6&db=m Desensitization of the epidermal adenylate cyclase system: agonists and phorbol esters desensitize by independent mechanisms. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1646827&form=6&db=m Bradykinin receptors of cerebral microvessels stimulate phosphoinositide turnover. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1646842&form=6&db=m Arachidonic acid as a second messenger. Interactions with a GTP-binding protein of human neutrophils. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1647049&form=6&db=m Stable inhibition of adenylate cyclase by muscarinic agonist in rat parotid gland: effects of neomycin and pertussis toxin. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1647255&form=6&db=m The bradykinin receptor--a putative receptor-operated channel in PC12 cells: studies of neurotransmitter release and inositol phosphate accumulation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1647665&form=6&db=m Inhibition of Ca2+ channels via alpha 2-adrenergic and muscarinic receptors in pheochromocytoma (PC-12) cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1647673&form=6&db=m Actions of peptide YY and neuropeptide Y on chief cells from guinea pig stomach. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1647853&form=6&db=m Antagonists of epithelial chloride channels inhibit cAMP synthesis. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1648085&form=6&db=m Reciprocal modulation of thyrotropin actions by P1-purinergic agonists in FRTL-5 thyroid cells. Inhibition of cAMP pathway and stimulation of phospholipase C-Ca2+ pathway. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1648349&form=6&db=m Heat treatment induces an increase in intracellular cyclic AMP content in human epidermoid A-431 cells. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1648404&form=6&db=m Binding of NAD+ to pertussis toxin. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1648626&form=6&db=m Differential effect of pertussis toxin on adenosine and muscarinic inhibition of cyclic AMP accumulation in canine ventricular myocytes. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1649188&form=6&db=m The epidermal growth factor receptor is coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rat hepatocytes. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1649661&form=6&db=m Bradykinin stimulates production of inositol (1,4,5) trisphosphate in cultured mesangial cells of the rat via a BK2-kinin receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1650296&form=6&db=m Dysfunction of the beta- and alpha-adrenergic systems in a model of congestive heart failure. The pacing-overdrive dog. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1650389&form=6&db=m Neutrophil CR3 expression and specific granule exocytosis are controlled by different signal transduction pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1650398&form=6&db=m Adenosine inhibits histamine-induced phosphoinositide hydrolysis mediated via pertussis toxin-sensitive G protein in human astrocytoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1650470&form=6&db=m A transduction pathway associated with receptors coupled to the inhibitory guanine nucleotide binding protein Gi that amplifies ATP-mediated arachidonic acid release. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1650710&form=6&db=m The effect of glycosyl inositol-phosphate on cAMP production in isolated rat fat-cells is transduced by a pertussis toxin sensitive G-protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1650771&form=6&db=m Possible coupling of prostaglandin E2 receptor with pertussis toxin-sensitive guanine nucleotide-binding protein in osteoblast-like cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1650837&form=6&db=m Activation of phospholipase D by E-series prostaglandins in human erythroleukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1651519&form=6&db=m Dissociation of opioid receptor upregulation and functional supersensitivity. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1651658&form=6&db=m Stimulatory and inhibitory actions of carbachol on chloride secretory responses in human colonic cell line T84. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1651723&form=6&db=m Astrocytes possess prostaglandin F2 alpha receptors coupled to phospholipase C. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1651854&form=6&db=m Alpha 1-adrenergic receptor coupling with phospholipase-C is negatively regulated by protein kinase-C in primary cultures of hypothalamic neurons and glial cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1651979&form=6&db=m The nature and origin of spontaneous noise in G protein-gated ion channels. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652000&form=6&db=m The neuropeptide FMRFa both inhibits and enhances the Ca2+ current in dissociated Helix neurons via independent mechanisms. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652030&form=6&db=m Angiotensin II directly increases rabbit renal brush-border membrane sodium transport: presence of local signal transduction system. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652051&form=6&db=m Glucocorticoid receptor activation leads to up-regulation of adenosine A1 receptors and down-regulation of adenosine A2 responses in DDT1 MF-2 smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652053&form=6&db=m Functional responses of cloned muscarinic receptors expressed in CHO-K1 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652077&form=6&db=m Evidence for kinetic disparity among pertussis toxin substrate G-proteins coupled to opiate receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652183&form=6&db=m Localization of several G-protein subunits to the apical and basolateral membranes of cortical tubular cells from the rat kidney. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652206&form=6&db=m Fluoride mobilizes intracellular calcium and promotes Ca2+ influx in rat proximal tubules. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652482&form=6&db=m Stimulation of DNA synthesis in Jurkat cells by synergistic action between adenine and guanine nucleotides. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652562&form=6&db=m Characterization of vir-activated TnphoA gene fusions in Bordetella pertussis. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652651&form=6&db=m Age-related alterations in adenylyl cyclase system of rat hearts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652938&form=6&db=m The presence of atrial-natriuretic-factor receptors of ANF-R2 subtype in rat platelets. Coupling to adenylate cyclase/cyclic AMP signal-transduction system. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652940&form=6&db=m Does cyclic guanosine monophosphate mediate noradrenaline-induced inhibition of islet insulin secretion stimulated by glucose and palmitate? causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652944&form=6&db=m Distinct mode of G protein activation due to single residue substitution of active IGF-II receptor peptide Arg2410-Lys2423: evidence for stimulation acceptor region other than C-terminus of Gi alpha. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1653068&form=6&db=m Cyclic AMP counteracts mitogen-induced inositol phosphate generation and increases in intracellular Ca2+ concentrations in human lymphocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1653071&form=6&db=m Regulation of bradykinin receptor level by cholera toxin, pertussis toxin and forskolin in cultured human fibroblasts. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1653322&form=6&db=m Autoreceptor-mediated purinergic and cholinergic inhibition of motor nerve terminal calcium currents in the rat. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1653359&form=6&db=m Acetylcholine reverses isoproterenol-induced depression of Vmax in residual Na channel-dependent action potentials of guinea-pig cardiac muscles. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1653524&form=6&db=m Modulation of leukotriene B4 and platelet-activating factor binding to neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1653845&form=6&db=m Pertussis toxin inhibits hormonal stimulation of bone resorption in fetal rat limb bones. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1653846&form=6&db=m The m2 muscarinic acetylcholine receptors are coupled to multiple signaling pathways via pertussis toxin-sensitive guanine nucleotide regulatory proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1653857&form=6&db=m Early alterations of Gi/Go protein-dependent transductional processes in the retina of diabetic animals. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1653887&form=6&db=m Effects of age on muscarinic agonist-induced contraction and IP accumulation in airway smooth muscle. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1653970&form=6&db=m Modulation of cardiac sodium channels by cAMP receptors on the myocyte surface. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1654004&form=6&db=m Muscarinic acetylcholine receptor-mediated phosphoinositide turnover in cultured human retinal pigment epithelium cells. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1654071&form=6&db=m Studies on the mechanisms of signalling and inhibition by pertussis toxin of fibroblast growth factor-stimulated mitogenesis in Balb/c 3T3 cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1654114&form=6&db=m Evidence for coupling of bradykinin receptors to a guanine-nucleotide binding protein to stimulate arachidonate liberation in the osteoblast-like cell line, MC3T3-E1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1654121&form=6&db=m A guanine nucleotide-binding protein mediates 1,25-dihydroxy-vitamin D-3-dependent rapid stimulation of Ca2+ uptake in skeletal muscle. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1654412&form=6&db=m Different types of glutamate receptors in isolated and identified neurones of the mollusc Planorbarius corneus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1654722&form=6&db=m Muscarinic regulation of phospholipase A2 and iodide fluxes in FRTL-5 thyroid cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1654878&form=6&db=m Characterization of a mastoparan-stimulated nucleotidase from bovine brain. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1654940&form=6&db=m Purification and immunological characterization of HPLC-purified pertussis toxin subunits. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1655387&form=6&db=m Nongenomic actions of 1,25-dihydroxyvitamin D3 in rat osteosarcoma cells: structure-function studies using ligand analogs. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1655395&form=6&db=m Involvement of protein kinase-C in the effect of angiotensin-II on adenosine 3',5'-monophosphate production in lactotroph cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1655469&form=6&db=m A pertussis toxin-sensitive process controls thymocyte emigration. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1655474&form=6&db=m Intracerebroventricular pertussis toxin enhances sensitivity to N-methyl-D-aspartate-induced seizures in mice. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1655489&form=6&db=m Effects of mastoparan and related peptides on phosphoinositide breakdown in HL-60 cells and cell-free preparations. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1655517&form=6&db=m Tumor cell autocrine motility factor receptor. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1655527&form=6&db=m Inhibition of fetal rat pancreatic beta-cell replication by interleukin-1 beta in vitro is not mediated through pertussis toxin-sensitive G-proteins, a decrease in cyclic AMP, or protease activation. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1655781&form=6&db=m Suppression of cytoskeletal rearrangement in activated human neutrophils by botulinum C2 toxin. Impact on cellular signal transduction. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1655905&form=6&db=m Differentiation-linked activation of the respiratory burst in a monocytic cell line (U937) via Fc gamma RII. A study of activation pathways and their regulation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1656017&form=6&db=m Guanine nucleotide-binding proteins modulate desmethoxyverapamil binding to calcium channels in vascular smooth muscle. diagnostic usage,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1656335&form=6&db=m Inhibitory modulation of fast and slow Ca(2+)-currents in neuroblastoma x glioma cells during differentiation. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1656397&form=6&db=m Effects of neuropeptide Y on forskolin, alpha 2- and beta-adrenoceptor-regulated cAMP levels in the rat brain slice. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1656402&form=6&db=m Treatment with pertussis toxin does not prevent central effects of eel calcitonin. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1656456&form=6&db=m Tonic inhibition and rebound facilitation of a neuronal calcium channel by a GTP-binding protein. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1656524&form=6&db=m Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1656792&form=6&db=m Two types of G proteins involved in regulation of phosphoinositide turnover in pulmonary endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1656796&form=6&db=m Na(+)-K(+)-ATPase-G protein coupling in myocardial sarcolemma: separation and reconstitution. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1656965&form=6&db=m Endothelins inhibit adenylate cyclase in brain capillary endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1657061&form=6&db=m Mechanisms of calcium mobilization and phosphoinositide hydrolysis in human bronchial smooth muscle cells by endothelin 1. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1657097&form=6&db=m Expression of val-12 mutant ras p21 in an IL-3-dependent murine myeloid cell line is associated with loss of serum-dependence and increases in membrane PIP2-specific phospholipase C activity. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1657372&form=6&db=m Regulation of kinesin expression and type IV collagenase secretion in invasive human prostate PC-3 tumor sublines. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1657619&form=6&db=m Endogenous angiotensin II receptors in Xenopus oocytes and eggs. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1657623&form=6&db=m Differential coupling of muscarinic receptors to Ca2+ mobilization and cyclic AMP in SH-SY5Y and IMR 32 neuroblastoma cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1657797&form=6&db=m Comparison of autocrine mechanisms promoting motility in two metastatic cell lines: human melanoma and ras-transfected NIH3T3 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1657996&form=6&db=m Pertussis toxin-sensitive Gi protein involvement in epidermal growth factor-induced activation of phospholipase C-gamma in rat hepatocytes. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1658602&form=6&db=m Prostaglandin receptors in NIH 3T3 cells: coupling of one receptor to adenylate cyclase and of a second receptor to phospholipase C. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1658606&form=6&db=m Multiple Gi protein subtypes regulate a single effector mechanism. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1658634&form=6&db=m Inhibition of voltage-dependent Ca2+ currents and activation of pertussis toxin-sensitive G-proteins via muscarinic receptors in GH3 cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1658727&form=6&db=m Adrenergic and cholinergic inhibition of Ca2+ channels mediated by different GTP-binding proteins in rat sympathetic neurones. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1659216&form=6&db=m Adenosine A1-receptor coupling to phosphoinositide metabolism in pregnant guinea pig myometrium. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1659225&form=6&db=m Mechanism of sodium transport inhibition by epidermal growth factor in cortical collecting ducts. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1659503&form=6&db=m Beta-adrenergic receptor-G protein-adenylate cyclase complex in experimental canine congestive heart failure produced by rapid ventricular pacing. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1659574&form=6&db=m Transcription of the muscle regulatory gene Myf4 is regulated by serum components, peptide growth factors and signaling pathways involving G proteins. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1659908&form=6&db=m Muscarinic receptor-linked elevation of cAMP in SH-SY5Y neuroblastoma cells is mediated by Ca2+ and protein kinase C. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1660138&form=6&db=m Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1660349&form=6&db=m Modulation of muscarinic receptor-mediated adenylate cyclase and phospholipase C responses in rat retina. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1660361&form=6&db=m Involvement of a GTP-binding protein in stimulating action of angiotensin II on calcium channels in vascular smooth muscle cells. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1660466&form=6&db=m Activation of a phosphatidylcholine-specific phospholipase C by colony stimulating factor 1 receptor requires tyrosine phosphorylation and a guanine nucleotide-binding protein. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1660534&form=6&db=m The involvement of GABAB receptors and coupled G-proteins in spinal GABAergic presynaptic inhibition. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1660537&form=6&db=m Regulation of bradykinin- and ATP-activated Ca(2+)-permeable channels in rat pheochromocytoma (PC12) cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1660557&form=6&db=m Mechanisms of action of cyclosporin A on islet alpha- and beta-cells. Effects on cAMP- and calcium-dependent pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1660881&form=6&db=m Cell-specific signaling of the 5-HT1A receptor. Modulation by protein kinases C and A. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1660989&form=6&db=m Spider toxin and pertussis toxin differentiate post- and presynaptic glutamate receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1661086&form=6&db=m Positive and negative contractile effects of neuropeptide Y on ventricular cardiomyocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1661143&form=6&db=m Nucleotide exchange and cGMP phosphodiesterase activation by pertussis toxin inactivated transducin. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1661194&form=6&db=m Binding interaction of gamma aminobutyric acid A and B receptors in cell culture. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1661840&form=6&db=m Muscarinic receptors in canine colonic circular smooth muscle. II. Signal transduction pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1661865&form=6&db=m Neuropeptide Y and sigma ligand (JO 1784) act through a Gi protein to block the psychological stress and corticotropin-releasing factor-induced colonic motor activation in rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1662113&form=6&db=m Effects of phorbol esters and pertussis toxin on calcitonin-stimulated accumulation of cyclic AMP in neonatal mouse calvarial bones. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1662135&form=6&db=m Functional modification by cholera-toxin-catalyzed ADP-ribosylation of a guanine-nucleotide-binding regulatory protein serving as the substrate of pertussis toxin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1662283&form=6&db=m Tumor necrosis factor inhibits K+ current expression in cultured oligodendrocytes. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1662486&form=6&db=m Phospholipase C-beta 1 is regulated by a pertussis toxin-insensitive G-protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1662511&form=6&db=m Epidermal growth factor activation of rat parotid gland adenylate cyclase and mediation by a GTP-binding regulatory protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1662619&form=6&db=m Activation of a keratinocyte phospholipase A2 by bradykinin and 4 beta-phorbol 12-myristate 13-acetate. Evidence for a receptor-GTP-binding protein versus a protein-kinase-C mediated mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1663046&form=6&db=m Modulation of [3H]dihydropyridine binding by activation of protein kinase C in vascular smooth muscle. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1663161&form=6&db=m Analysis of adenosine actions on Ca2+ currents and synaptic transmission in cultured rat hippocampal pyramidal neurones. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1663218&form=6&db=m Endothelin receptor binding and cellular signal transduction in neurohybrid NG108-15 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1663494&form=6&db=m Effects of pertussis toxin, dibutyryl-cyclic-AMP, bromo-cyclic-AMP and forskolin on the behavioural and electrocortical power spectrum changes induced by microinfusion of interleukin-2 into the locus coeruleus. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1663584&form=6&db=m G-protein coupling and signalling of Y1-like neuropeptide Y receptors in SK-N-MC cells. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1663609&form=6&db=m Pertussis-toxin-sensitive inhibition by (-) baclofen of Ca signals in bovine chromaffin cells. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1663982&form=6&db=m Pressor actions of arginine vasopressin in pithed Sprague-Dawley, Wistar-Kyoto and spontaneously hypertensive rats before and after treatment with nifedipine or pertussis toxin. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1664681&form=6&db=m Mitogenic effects of fibroblast growth factors in cultured fibroblasts. Interaction with the G-protein-mediated signaling pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1664739&form=6&db=m Effect of fluoride, pertussis and cholera toxin on the release of arachidonic acid and the formation of prostaglandin E2, D2, superoxide and inositol phosphates in rat liver macrophages. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1664860&form=6&db=m Apical and basolateral effects of PTH in OK cells: transport inhibition, messenger production, effects of pertussis toxin, and interaction with a PTH analog. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1664949&form=6&db=m Pertussis toxin reduces the day-night rhythm of nociception and mu and kappa opioid peptide-mediated antinociception in the snail, Cepaea nemoralis. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1665262&form=6&db=m Pharmacology of Ca2+ channels in smooth muscle. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1665289&form=6&db=m Changes in inositol 1,4,5-trisphosphate mass in agonist-stimulated human neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1665862&form=6&db=m The modulation of rat hippocampal synaptic conductances by baclofen and gamma-aminobutyric acid. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1665995&form=6&db=m Distribution and pharmacological characterization of muscarinic-cholinergic receptors in the cockroach brain. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1666059&form=6&db=m Glutathione-induced enhancement of neutrophil locomotion. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1666417&form=6&db=m M1 acetylcholine receptor-mediated phosphatidylinositol turnover in adult and senescent rat brain slices. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1666808&form=6&db=m Polyarginine, polylysine, and protamine mimic the effects of high extracellular calcium concentrations on dispersed bovine parathyroid cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1666919&form=6&db=m G-protein mediation of cannabinoid-induced phospholipase activation. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1667293&form=6&db=m Aggregation of pigment granules in single cultured Xenopus laevis melanophores by melatonin analogues. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1667331&form=6&db=m Role of a pertussis toxin sensitive G-protein in mediating the effects of phorbol esters on receptor activated cyclic AMP accumulation in Jurkat cells. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1667384&form=6&db=m Pertussis toxin abolishes mu- and delta-opioid agonist-induced place preference. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1667545&form=6&db=m Mechanisms of opioid actions on neurons of the locus coeruleus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1667803&form=6&db=m Alpha 1-adrenoceptors reduce background K+ current in rabbit ventricular myocytes. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1668102&form=6&db=m Inositol phospholipid turnover in PAF transmembrane signalling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1668103&form=6&db=m PAF effects on transmembrane signaling pathways in rat Kupffer cells. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1668352&form=6&db=m GABAB receptor-mediated inhibition of Ca2+ currents and synaptic transmission in cultured rat hippocampal neurones. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1668990&form=6&db=m Role of the protein kinase C signaling pathway in high-density lipoprotein receptor-mediated efflux of intracellular cholesterol. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1670725&form=6&db=m Phase II trial of whole-cell pertussis vaccine vs an acellular vaccine containing agglutinogens. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1671085&form=6&db=m Characterization of prostaglandin E2-induced Ca2+ mobilization in single bovine adrenal chromaffin cells by digital image microscopy. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1671790&form=6&db=m The opposing effects of calmodulin, adenosine 5'-triphosphate, and pertussis toxin on phorbol ester induced inhibition of atrial natriuretic factor stimulated guanylate cyclase in SK-NEP-1 cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1672856&form=6&db=m The effect of vasoactive intestinal polypeptide on gastric acid secretion is predominantly mediated by somatostatin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1673079&form=6&db=m Subtypes of adrenergic receptors and intracellular mechanisms involved in modulatory effects of noradrenaline on glutamate. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1673142&form=6&db=m Penetration of CD4 T cells by HIV-1. The CD4 receptor does not internalize with HIV, and CD4-related signal transduction events are not required for entry. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1673223&form=6&db=m Naturally occurring opioid receptor agonists stimulate adenylate cyclase activity in rat olfactory bulb. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1673485&form=6&db=m Somatostatin-14 blocks the hepatotrophic effects of insulin in the rat. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1674000&form=6&db=m Pretreatment of cerebellar granule cells with concanavalin A potentiates quisqualate-stimulated phosphoinositide hydrolysis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1674473&form=6&db=m Somatostatin induced hyperpolarization of septal neurons is not blocked by pertussis toxin. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1674688&form=6&db=m Regulation of intestinal proglucagon-derived peptide secretion by intestinal regulatory peptides. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1674742&form=6&db=m The interaction of a kainate receptor from goldfish brain with a pertussis toxin-sensitive GTP-binding protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1674758&form=6&db=m Beta adrenergic modulation of cardiac rhythm in a rat model of altered sympathetic neural development. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1675492&form=6&db=m Does whole-cell pertussis vaccine protect black South African infants? Assessment of post-vaccination events and antibody responses to pertussis toxin, filamentous haemagglutinin and agglutinogens 2 and 3. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1675832&form=6&db=m Histamine H1-receptors on astrocytes in primary cultures: a possible target for histaminergic neurones. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1676678&form=6&db=m Effect of Gi protein ADP-ribosylation induced by pertussis toxin on dopamine-mediated behaviors. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1676694&form=6&db=m The effect of pertussis toxin on alpha 1-adrenoceptor-mediated vasoconstriction by the full agonist, cirazoline, and the partial agonist, (-)-dobutamine, in pithed rats. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1676971&form=6&db=m Calcium signaling capacity of the CD11b/CD18 integrin on human neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1677535&form=6&db=m Inhibition of muscle cell relaxation by somatostatin: tissue-specific, cAMP-dependent, pertussis toxin-sensitive. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1678017&form=6&db=m A WB 4101-sensitive alpha-1 adrenergic receptor subtype modulates repolarization in canine Purkinje fibers. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1678423&form=6&db=m Neurotransmitter modulation of calcium channels in rat sympathetic neurons. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1678567&form=6&db=m [The phenotypic properties of freshly isolated strains of Bordetella] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1679848&form=6&db=m Regulation of G proteins by chronic opiate and clonidine treatment in the guinea pig myenteric plexus. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1679850&form=6&db=m gamma-Aminobutyric acid-B receptors inhibit glutamate release from cerebellar granule cells: consequences of inhibiting cyclic AMP formation and calcium influx. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1680517&form=6&db=m Desensitization and functional antagonism by beta-adrenoceptor and muscarinic receptor agonists, respectively: a comparison with receptor alkylation for calculation of apparent agonist affinity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1680564&form=6&db=m Morphoregulatory activities of NCAM and N-cadherin can be accounted for by G protein-dependent activation of L- and N-type neuronal Ca2+ channels. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1680855&form=6&db=m Involvement of pertussis toxin-sensitive G-proteins in the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insulin-secreting cell line (RINm5F). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1681018&form=6&db=m Immunogenicity of primary DPT vaccination. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1681036&form=6&db=m Dopaminergic receptors linked to adenylate cyclase in human cerebromicrovascular endothelium. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1681548&form=6&db=m Somatostatin potentiates the alpha 1-adrenergic activation of phospholipase C in striatal astrocytes through a mechanism involving arachidonic acid and glutamate. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1681784&form=6&db=m Solubilization and reprecipitation from intestinal brush border membranes of a complex containing guanylate cyclase activatable by the heat-stable enterotoxin. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1681806&form=6&db=m Alpha-adrenergic inhibition of rat pancreatic beta-cell replication and insulin secretion is mediated through a pertussis toxin-sensitive G-protein regulating islet cAMP content. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1682005&form=6&db=m Guanine nucleotide binding proteins and the regulation of cyclic AMP synthesis in NS20Y neuroblastoma cells: role of D1 dopamine and muscarinic receptors. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1682135&form=6&db=m Somatostatin and epinephrine decrease insulin messenger ribonucleic acid in HIT cells through a pertussis toxin-sensitive mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1682257&form=6&db=m Construction of minitransposons for constitutive and inducible expression of pertussis toxin in bvg-negative Bordetella bronchiseptica. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1683272&form=6&db=m Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1683639&form=6&db=m [Isoproterenol, denopamine, and atenolol-induced alterations in beta-adrenergic receptor-adenylate cyclase system of rat myocardium] diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1683900&form=6&db=m FMRFamide modulation of secretory machinery underlying presynaptic inhibition of synaptic transmission requires a pertussis toxin-sensitive G-protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1684410&form=6&db=m Properties of Ca2+ currents in acutely dissociated neurons of the chick ciliary ganglion: inhibition by somatostatin-14 and somatostatin-28. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1686069&form=6&db=m Why are several inhibitory transmitters present in the innervation of pituitary melanotrophs? Actions and interactions of dopamine, GABA and neuropeptide Y on secretion from neurointermediate lobes of Xenopus laevis. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1686417&form=6&db=m Modulation of vertebrate neuronal calcium channels by transmitters. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1687374&form=6&db=m Effects of locally applied D1 and D2 agonists on striatal neurons with 6-OHDA and pertussis toxin lesions. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1687395&form=6&db=m Is the inhibitory effect of somatostatin on the heart due to K+ channel activation? therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1688553&form=6&db=m Histidine regulation of cyclic AMP metabolism in cultured renal epithelial LLC-PK1 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1688845&form=6&db=m Coupling of a cloned rat dopamine-D2 receptor to inhibition of adenylyl cyclase and prolactin secretion. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1689454&form=6&db=m Protein kinase C activators sensitize cyclic AMP accumulation by intact 1321N1 human astrocytoma cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1690150&form=6&db=m The formyl peptide chemoattractant receptor is encoded by a 2 kilobase messenger RNA. Expression in Xenopus oocytes. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1690613&form=6&db=m Chloride efflux in cyclic AMP-induced configurational change of bovine pulmonary artery endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1690652&form=6&db=m Modulation of dihydropyridine-sensitive calcium channels: a role for G proteins. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1691172&form=6&db=m Direct stimulation of adenylate cyclase by mechanical forces in S49 mouse lymphoma cells during hyposmotic swelling. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1691176&form=6&db=m Phospholipase C activity in NCB-20 cells is inhibited by protein kinase A-mediated phosphorylation of low molecular mass GTP-binding proteins. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1691721&form=6&db=m Proliferation of bovine undifferentiated mammary epithelial cells in vitro is modulated by G-proteins. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1691761&form=6&db=m Determination of T cell epitopes on the S1 subunit of pertussis toxin. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1691783&form=6&db=m Comparison between the vasoactive actions of endothelin and arginine vasopressin in pithed rats after pretreatment with BAY K 8644, nifedipine or pertussis toxin. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1692601&form=6&db=m Effect of ICV pertussis toxin and N-ethylmaleimide on the levels of substance P and serotonin in brain and spinal cord of the rat. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1693402&form=6&db=m Inositol trisphosphate mediates cloned muscarinic receptor-activated conductances in transfected mouse fibroblast A9 L cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1693850&form=6&db=m Intracellular coupling of prostaglandin inhibition of acid secretion in isolated rabbit gastric parietal cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1694260&form=6&db=m Immunological characterization of guanine nucleotide-binding proteins: effects of a monoclonal antibody against the gamma subunit of transducin on guanine nucleotide-binding protein-receptor interactions. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1694399&form=6&db=m Acetylcholine activates nonselective cation channels in guinea pig ileum through a G protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1694846&form=6&db=m Characterization of phagocyte P2 nucleotide receptors expressed in Xenopus oocytes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1695244&form=6&db=m Cyclic AMP-dependent induction of serotonin N-acetyltransferase activity in photoreceptor-enriched chick retinal cell cultures: characterization and inhibition by dopamine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1695328&form=6&db=m Effects of GTP, forskolin, sodium fluoride, serotonin, dopamine, and carbachol on adenylate cyclase in Teleost retina. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1695471&form=6&db=m Role of phospholipase A2 and G-proteins in the IgE-dependent activation of mast cells and macrophages. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1695472&form=6&db=m A pertussis toxin-sensitive G protein is required to induce histamine release from rat peritoneal mast cells by bradykinin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1696150&form=6&db=m NaF and guanine nucleotides modulate adenylate cyclase activity in NG108-15 cells by interacting with both Gs and Gi. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1696631&form=6&db=m Cellular mechanisms of somatostatin inhibition of calcium influx in the anterior pituitary cell line AtT-20. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1696702&form=6&db=m Second messengers involved in genetic regulation of the number of calcium channels in bovine adrenal chromaffin cells in culture. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1696725&form=6&db=m Microsomal and cytosolic fractions of guinea pig hepatocytes contain 100-kilodalton GTP-binding proteins reactive with antisera against alpha subunits of stimulatory and inhibitory heterotrimeric GTP-binding proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1696982&form=6&db=m Endogenous modulation of ACh release by somatostatin and the differential roles of Ca2+ channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1697300&form=6&db=m Exocytosis in mast cells by basic secretagogues: evidence for direct activation of GTP-binding proteins. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1697681&form=6&db=m Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1697878&form=6&db=m Tyrosine phosphorylation is an obligatory event in IL-2 secretion. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1698055&form=6&db=m Evidence that the epidermal growth factor receptor and non-tyrosine kinase hormone receptors stimulate phosphoinositide hydrolysis by independent pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1698179&form=6&db=m Protective activities in mice of monoclonal antibodies against pertussis toxin. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1698450&form=6&db=m Binding of ATP by pertussis toxin and isolated toxin subunits. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1698537&form=6&db=m Functional interactions between colony-stimulating factors and the insulin family hormones for human myeloid leukemic cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1698571&form=6&db=m The mechanism of positive inotropy induced by adenosine triphosphate in rat heart. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1698770&form=6&db=m A pertussis toxin-sensitive G-protein mediates some aspects of insulin action in BC3H-1 murine myocytes. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1699430&form=6&db=m Effect of substance P and neurokinin A on rat parietal cell function. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1700111&form=6&db=m GTP-binding proteins mediate noradrenaline effects on calcium and chloride currents in rat portal vein myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1700223&form=6&db=m Effects of nifedipine, BAY K 8644, and pertussis toxin on pressor response to sarafotoxin-b in pithed rats. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1700631&form=6&db=m Pertussis toxin abolishes the effect of neuropeptide Y on rat resistance arteriole contraction. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1700796&form=6&db=m Relationship between proliferation and cell cycle-dependent Ca2+ influx induced by a combination of thyrotropin and insulin-like growth factor-I in rat thyroid cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1700899&form=6&db=m Prostaglandins and muscarinic agonists induce cyclic AMP attenuation by two distinct mechanisms in the pregnant-rat myometrium. Interaction between cyclic AMP and Ca2+ signals. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1701162&form=6&db=m Interaction of substance P, compound 48/80 and mastoparan with the alpha-subunit C-terminus of G protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1701214&form=6&db=m Activation of Gi-like proteins, a receptor-independent effect of kinins in mast cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1702440&form=6&db=m Somatostatin inhibits insulin secretion by a G-protein-mediated decrease in Ca2+ entry through voltage-dependent Ca2+ channels in the beta cell. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1702496&form=6&db=m Effect of intrathecal injection of pertussis toxin on substance P, norepinephrine and serotonin contents in various neural structures of arthritic rats. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1702750&form=6&db=m FK506 and pertussis toxin distinguish growth-induced locomotor activation from attractant-stimulated locomotion in human blood lymphocytes. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1702767&form=6&db=m Properties of pertussis toxin mutant PT-9K/129G after formaldehyde treatment. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1702786&form=6&db=m Neomycin is a potent secretagogue of mast cells that directly activates a GTP-binding protein involved in exocytosis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1702803&form=6&db=m T cell lines specific for an immunodominant epitope of human basic protein define an encephalitogenic determinant for experimental autoimmune encephalomyelitis-resistant LOU/M rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1702875&form=6&db=m GABAB receptors expressed in Xenopus oocytes by guinea pig cerebral mRNA are functionally coupled with Ca2(+)-dependent Cl- channels and with K+ channels, through GTP-binding proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1703181&form=6&db=m Activation of dense human tonsilar B cells. Induction of c-myc gene expression via two distinct signal transduction pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1703192&form=6&db=m Modulation of Bordetella pertussis infection with monoclonal antibodies to pertussis toxin. diagnostic usage,ongoing research,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1703443&form=6&db=m Possible involvement of pertussis toxin-sensitive GTP-binding protein(s) in c-fos expression during differentiation of 3T3-L1 fibroblasts to adipocytes. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1703486&form=6&db=m Activation of alpha 2-adrenergic receptors decreases Ca2+ influx to inhibit insulin secretion in a hamster beta-cell line: an action mediated by a guanosine triphosphate-binding protein. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1704288&form=6&db=m Inhibition of calcium currents in cultured myenteric neurons by neuropeptide Y: evidence for direct receptor/channel coupling. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1704421&form=6&db=m Dihydropyridine modulation of voltage-activated calcium channels in PC12 cells: effect of pertussis toxin pretreatment. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1705478&form=6&db=m Galanin stimulates Ca2+ mobilization, inositol phosphate accumulation, and clonal growth in small cell lung cancer cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1706224&form=6&db=m Modulation of keratin intermediate filament distribution in vivo by induced changes in cyclic AMP-dependent phosphorylation. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1706271&form=6&db=m Involvement of dihydropyridine-sensitive calcium channels in the GABAA potentiation of TRH-induced TSH release. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1706321&form=6&db=m Identification of linear B-cell determinants of pertussis toxin associated with the receptor recognition site of the S3 subunit. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1706471&form=6&db=m Carbachol activates a novel sodium current in isolated guinea pig ventricular myocytes via M2 muscarinic receptors. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1706472&form=6&db=m Serum-induced sensitization of cyclic AMP accumulation in 1321N1 human astrocytoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1706813&form=6&db=m Pertussis toxin-sensitive G-protein activation does not influence the response to Bay K 8644 in embryonic chick myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1707002&form=6&db=m Chronic experimental autoimmune encephalomyelitis induced by the 89-101 myelin basic protein peptide in B10RIII (H-2r) mice. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1707518&form=6&db=m Atrial natriuretic factor increases cyclic GMP and cyclic AMP levels in a directly photosensitive pineal organ. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1707674&form=6&db=m Cellular mechanisms of bradykinin-induced hyperpolarization in renal epitheloid MDCK-cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1707706&form=6&db=m Effects of cyclic AMP-affecting agents on contractile reactivity of isolated mesenteric and renal resistance arteries of the rat. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1707816&form=6&db=m Cardiovascular responses to milrinone in pertussis toxin-pretreated pithed rats. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1707817&form=6&db=m Galanin inhibits somatostatin release by the rat islet cell tumor in culture, Rin-m. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1708104&form=6&db=m Detoxification of pertussis toxin by site-directed mutagenesis: a review of connaught strategy to develop a recombinant pertussis vaccine. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1708105&form=6&db=m Epitope specificity of three anti-pertussis toxin monoclonal antibodies with dissimilar effects in assays of toxin neutralizing activity. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1708205&form=6&db=m Chloride channel blockers inhibit ACTH secretion from mouse pituitary tumor cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1708239&form=6&db=m Differential regulation of thrombin- or ATP-induced mobilization of intracellular Ca2+ by prostacyclin receptor in mouse mastocytoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1709122&form=6&db=m Effect of pertussis toxin on islet insulin secretion in obese (fa/fa) Zucker rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1709171&form=6&db=m Mastoparan, a novel mitogen for Swiss 3T3 cells, stimulates pertussis toxin-sensitive arachidonic acid release without inositol phosphate accumulation. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1709748&form=6&db=m Functional and molecular characterization of CCK receptors in the rat pancreatic acinar cell line AR 4-2J. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1709784&form=6&db=m Tyrosine phosphorylation and oxygen consumption induced by G proteins in neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1709925&form=6&db=m Activation of mitogen-activated protein kinase in BC3H1 myocytes by fluoroaluminate. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1709941&form=6&db=m Modulation of responsiveness to cAMP stimulating agonists by phorbol ester in fetal rat osteoblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1710239&form=6&db=m CD69 in resting and activated T lymphocytes. Its association with a GTP binding protein and biochemical requirements for its expression. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1710785&form=6&db=m Inhibitory prejunctional muscarinic receptors at sympathetic nerves do not operate through a cyclic AMP dependent pathway. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1711622&form=6&db=m Mr 40,000 and Mr 39,000 pertussis toxin substrates are increased in surgically denervated dog ventricular myocardium. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1711782&form=6&db=m GLP-1-(7-36) amide, -(1-37), and -(1-36) amide: potent cAMP-dependent stimuli of rat parietal cell function. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1712584&form=6&db=m Carbachol enhances forskolin-stimulated cyclic AMP accumulation via activation of calmodulin system in human neuroblastoma SH-SY5Y cells. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1714064&form=6&db=m Pertussis toxin-sensitive G-protein mediates galanin's inhibition of scopolamine-evoked acetylcholine release in vivo and carbachol-stimulated phosphoinositide turnover in rat ventral hippocampus. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1714959&form=6&db=m Pertussis toxin stimulation of catecholamine release from adrenal medullary chromaffin cells: mechanism may be by direct activation of L-type and G-type calcium channels. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1715380&form=6&db=m Substance P stimulation of polyphosphoinositide hydrolysis in rat anterior pituitary membranes involves a GTP-dependent mechanism. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1715709&form=6&db=m Signal transduction alterations in GH(1)2C1 rat pituitary tumour cells following treatment with 5-azacytidine. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1715770&form=6&db=m Modification of biological responses to interleukin-1 by agents that perturb signal transduction pathways. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1715794&form=6&db=m Inhibition by galanin and by high K+ of human basophil histamine release triggered by calcium ionophores but not responses induced by anti-IgE, chemotactic peptide or phorbol ester. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1716061&form=6&db=m Cellular mechanism of lithium-induced nephrogenic diabetes insipidus in rats. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1716387&form=6&db=m Light-induced, GTP-binding protein mediated membrane currents of Xenopus oocytes injected with rhodopsin of cephalopods. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1716578&form=6&db=m Norepinephrine inhibits a Ca2+ current in rat sympathetic neurons via a G-protein. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1716580&form=6&db=m Evidence for the interaction of mast cell-degranulating peptide with pertussis toxin-sensitive G proteins in mast cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1716614&form=6&db=m Lymphokine secretion and cytotoxic activity of human CD4+ T-cell clones against Bordetella pertussis. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1716675&form=6&db=m Dopamine actions on calcium currents, potassium currents and hormone release in rat melanotrophs. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1716843&form=6&db=m G-proteins as targets for non-immunological histamine releasers. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1716844&form=6&db=m Molecular basis for cellular effects of naturally occurring polyamines. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1717263&form=6&db=m Cloning, heterologous expression and developmental regulation of a Drosophila receptor for tachykinin-like peptides. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1718001&form=6&db=m Inhibition of cAMP accumulation by intracellular calcium mobilization in C6-2B cells stably transfected with substance K receptor cDNA. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1718246&form=6&db=m The stimuli releasing histamine from murine bone marrow-derived mast cells. 2. Mechanisms involved in histamine release induced by extracellular ATP and its metabolites. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1718542&form=6&db=m Inhibition of cAMP production by alpha 2-adrenoceptor stimulation in rabbit retina. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1718746&form=6&db=m Sequential activation and environmental regulation of virulence genes in Bordetella pertussis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1718802&form=6&db=m Identification of G protein alpha-subunits in RINm5F cells and their selective interaction with galanin receptor. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1718872&form=6&db=m Characterization of murine monoclonal antibodies that recognize defined epitopes of pertussis toxin and neutralize its toxic effect on Chinese hamster ovary cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1719074&form=6&db=m Pertussis toxin prevents the induction of peripheral T cell anergy and enhances the T cell response to an encephalitogenic peptide of myelin basic protein. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1719078&form=6&db=m Role of pertussis toxin-sensitive G proteins in stimulus-dependent human eosinophil degranulation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1719134&form=6&db=m Synergistic regulation of cytosolic Ca2+ concentration in mouse astrocytes by NK1 tachykinin and adenosine agonists. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1719553&form=6&db=m Thyrotropin-releasing hormone induces opposite effects on Ca2+ channel currents in pituitary cells by two pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1720612&form=6&db=m Bombesin, neuromedin B and neuromedin C interact with a common rat pancreatic phosphoinositide-coupled receptor, but are differentially regulated by guanine nucleotides. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1720802&form=6&db=m Recombinant human G-CSF and GM-CSF prime human neutrophils for superoxide production through different signal transduction mechanisms. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1720993&form=6&db=m Roles of cyclic GMP and inositol trisphosphate in phototransduction of the molluscan extraocular photoreceptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1721559&form=6&db=m Mechanisms of interaction between human skin fibroblasts and elastin: differences between elastin fibres and derived peptides. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1722394&form=6&db=m Prostaglandin-concentration-dependent desensitization of adenylate cyclase in human erythroleukaemia (HEL) cells is abolished by pertussis toxin and enhanced by induction by dimethyl sulphoxide. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1722405&form=6&db=m Pertussis toxin inhibits autophosphorylation and activation of the insulin receptor kinase. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1722644&form=6&db=m Evidence that M3 muscarinic receptors in rat parotid gland couple to two second messenger systems. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1722894&form=6&db=m Dopamine regulates the electrical activity of frog melanotrophs through a G protein-mediated mechanism. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1723387&form=6&db=m Relationship between structure and biological and protective activities of pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1723766&form=6&db=m G proteins subserve relaxations mediated by adenosine receptors in human coronary artery. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1724605&form=6&db=m Characterization of monoclonal antibodies directed against domains of pertussis toxin involved in receptor recognition. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1725439&form=6&db=m Endothelin receptors and coupled GTP-binding proteins in glomerular mesangial cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1725440&form=6&db=m Endothelin-induced activation of phosphoinositide turnover, calcium mobilization, and transmitter release in cultured neurons and neurally related cell types. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1727688&form=6&db=m Expression and pharmacological characterization of a stimulatory subtype of adenosine receptor in fetal chick ventricular myocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1727698&form=6&db=m Mastoparan-induced hormone release from rat pancreatic islets. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1729677&form=6&db=m Pertussis toxin has eukaryotic-like carbohydrate recognition domains. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1730631&form=6&db=m Modification of the function of pertussis toxin substrate GTP-binding protein by cholera toxin-catalyzed ADP-ribosylation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1730649&form=6&db=m Expression and purification of functional G protein alpha subunits using a baculovirus expression system. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1731175&form=6&db=m Lithium administration modulates platelet Gi in humans. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1731754&form=6&db=m Epoxyeicosatrienoic acid stimulates ADP-ribosylation of a 52 kDa protein in rat liver cytosol. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1732703&form=6&db=m Pertussis-toxin insensitive enkephalin inhibition of adenylyl cyclase in lacrimal acinar cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1733145&form=6&db=m Pertussis antibodies, protection, and vaccine efficacy after household exposure. causal interaction,diagnostic usage,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1733255&form=6&db=m Protein kinase C differentially modulates PTH- and PGE2-sensitive adenylate cyclase in osteoblast-like cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1733718&form=6&db=m Melatonin inhibits gonadotropin-releasing hormone-induced elevation of intracellular Ca2+ in neonatal rat pituitary cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1733734&form=6&db=m The stimulatory and inhibitory effects of dopamine on prolactin secretion involve different G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1733949&form=6&db=m Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1736882&form=6&db=m Effects of litter removal on the lipolytic response and the regulatory components of the adenylate cyclase in adipocytes isolated from lactating rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1737935&form=6&db=m Stimulus-response coupling in monocytes infected with Leishmania. Attenuation of calcium transients is related to defective agonist-induced accumulation of inositol phosphates. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1747101&form=6&db=m Regulation of arachidonic acid release in vascular endothelium. Ca(2+)-dependent and -independent pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1747110&form=6&db=m Studies on the activation of human neutrophil 5-lipoxygenase induced by natural agonists and Ca2+ ionophore A23187. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1747127&form=6&db=m Inhibition by pertussis toxin of the activation of Na(+)-dependent uridine transport in dimethyl-sulphoxide-induced HL-60 leukaemia cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1747158&form=6&db=m Neuropeptide Y inhibits nicotinic cholinergic currents but not voltage-dependent calcium currents in bovine chromaffin cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1747218&form=6&db=m Altered expression of inhibitory guanine nucleotide regulatory proteins (Gi alpha) in spontaneously hypertensive rats. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1748655&form=6&db=m The carboxyl terminus of the S1 subunit of pertussis toxin confers high affinity binding to transducin. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1751630&form=6&db=m Cell-specific expression of guanine nucleotide-binding proteins in rat testicular cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1759491&form=6&db=m Safety and immunogenicity of hydrogen peroxide-inactivated pertussis toxoid in 18-month-old children. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1759492&form=6&db=m Phase I clinical trial of an acellular pertussis vaccine composed of genetically detoxified pertussis toxin combined with FHA and 69 kDa. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1759508&form=6&db=m Determination of circulating antibodies directed to pertussis toxin and of agglutinogens in children vaccinated with either the whole cell or component pertussis vaccine in France, Japan and Senegal. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1759527&form=6&db=m [Multispecific monoclonal antibodies] ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1759607&form=6&db=m Serotonin receptor heterogeneity and the role of potassium channels in neuronal excitability. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1760251&form=6&db=m Intracellular mechanisms involved in leukotriene C4-stimulated adhesion of U-937 cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1760252&form=6&db=m Effects of homo- and heterodimeric isoforms of PDGF on signalling events in rat renal mesangial cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1761164&form=6&db=m Potentiation of thyrotropin-releasing hormone-stimulated prolactin mRNA levels in GH3 cells by acetylcholine. causal interaction,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1762082&form=6&db=m Functional studies in the human submandibular duct cell line, HSG-PA, suggest a second salivary gland receptor subtype for nucleotides. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1764450&form=6&db=m The use of the potential-sensitive fluorescent probe bisoxonol in mast cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1767821&form=6&db=m Muscarinic inhibition of single KCa channels in smooth muscle cells by a pertussis-sensitive G protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1770997&form=6&db=m Limited distribution of pertussis toxin in rat brain after injection into the lateral cerebral ventricles. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1773087&form=6&db=m Light and norepinephrine similarly prevent damping of the melatonin rhythm in cultured chick pineal cells: regulation of coupling between the pacemaker and overt rhythms? therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1773821&form=6&db=m The myocardial depressant effect of volatile anesthetics does not involve arachidonic acid metabolites or pertussis toxin-sensitive G proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1775589&form=6&db=m Signal transduction modulation by lithium: cell culture, cerebral microdialysis and human studies. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1775835&form=6&db=m Pertussis encephalopathy in an adult: case report and review. causal interaction,diagnostic usage,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1775855&form=6&db=m Seroepidemiology of pertussis in Italy. diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1777507&form=6&db=m p42/mitogen-activated protein kinase as a converging target for different growth factor signaling pathways: use of pertussis toxin as a discrimination factor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1778305&form=6&db=m Protective immunogenicity of synthetic peptides selected from the amino acid sequence of Bordetella pertussis toxin subunit S1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1778307&form=6&db=m Monoclonal antibodies against the enzymatic subunit of both pertussis and cholera toxins. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1778308&form=6&db=m Evaluation of antibodies elicited by immunization with pertussis toxin. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1778310&form=6&db=m An improved ELISA system for the measurement of IgG antibodies against pertussis toxin (PT) and filamentous hemagglutinin (FHA) in human sera. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1778314&form=6&db=m Production of a safe, potent and immunogenic partially purified acellular pertussis vaccine using simple indigenous techniques. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1778315&form=6&db=m Further evaluation of the pertussis component vaccine produced by apoceruloplasmin affinity chromatography. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1778316&form=6&db=m A novel bivalent acellular pertussis vaccine based on the 69 kDa protein and FHA. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1778335&form=6&db=m Construction and characterization of genetically inactivated pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1778336&form=6&db=m The molecular engineering of pertussis toxoid. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1778337&form=6&db=m Expression of the S1 sub-unit of pertussis toxin using a recombinant baculovirus. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1778339&form=6&db=m Characterization of mutant strains producing pertussis toxin cross reacting materials. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1778978&form=6&db=m Immuno-affinity purification and characterization of the alpha subunits of G0 type G proteins from various bovine tissues. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1784275&form=6&db=m Purification and characterization of G proteins from human brain: modification of GTPase activity upon phosphorylation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1786205&form=6&db=m Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1786208&form=6&db=m Diabetes decreases sensitivity of adipocyte lipolysis to inhibition by Gi-linked receptor agonists. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1788290&form=6&db=m Pertussis toxin increases sensitivity to the lethal effect of morphine in mice. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1791921&form=6&db=m Endothelin stimulates 86Rb efflux in rat glioma C6-Bu-1 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1795024&form=6&db=m Quantitation of actin polymerization in two human fibroblast sub-types responding to mechanical stretching. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1795882&form=6&db=m Suppression of kindled seizure following intraamygdaloid injection of pertussis toxin in rats. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1797049&form=6&db=m The cell mediated and humoral immune response to vaccination with acellular and whole cell pertussis vaccine in adult humans. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1797132&form=6&db=m Effects of pertussis toxin on the erythropoietin-stimulated proliferation and differentiation of erythroid-responsive cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1800121&form=6&db=m Pertussis toxin attenuates postsynaptic actions of neuropeptide Y on the guinea-pig uterine artery. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1800126&form=6&db=m Thrombin signalling in U937 human monocytic cells is coupled to inositol phosphate formation but not to thromboxane B2 synthesis nor to inhibition of adenylate cyclase: distinct differences in thrombin signalling between U937 cells and platelets. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1803347&form=6&db=m Lithium does not alter ADP-ribosylation of Gi/Go catalyzed by pertussis toxin in rat brain. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1804634&form=6&db=m G protein function in the ischaemic myocardium. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1806946&form=6&db=m The cannabinoid receptor: biochemical and cellular properties in neuroblastoma cells. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1810255&form=6&db=m Pertussis toxin-insensitive regulation of phosphatidylinositol hydrolysis by vanadate in brain microvessels. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1824251&form=6&db=m Pertussis toxin selectively interferes with the responses of the HL-60 human promyelocytic cell line to dimethylsulfoxide. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1824779&form=6&db=m Neurotensin decreases the affinity of dopamine D2 agonist binding by a G protein-independent mechanism. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1825152&form=6&db=m Mechanisms of rapid desensitization to arginine vasopressin in vascular smooth muscle cells. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1826092&form=6&db=m Internalization pathway of C3b receptors in human neutrophils and its transmodulation by chemoattractant receptors stimulation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1826680&form=6&db=m Selective loss of pertussis toxin-sensitive G-proteins from the plasma membrane after antibody-induced internalization of T-cell surface molecules. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1826973&form=6&db=m Glucocorticoid treatment reduces prostacyclin synthesis in response to limited stimuli. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1827488&form=6&db=m GTP-binding proteins transduce signals generated via human FC gamma receptor IIIA (CD16). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1827517&form=6&db=m Dopaminergic regulation of dopamine release from PC12 cells via a pertussis toxin-sensitive G protein. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1827986&form=6&db=m Pertussis toxin-sensitive G-proteins are not involved in activation of T-lymphocytes. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1828264&form=6&db=m Binding of IgG containing immune complexes to human neutrophil Fc gamma RII and Fc gamma RIII induces actin polymerization by a pertussis toxin-insensitive transduction pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1828885&form=6&db=m Different G proteins mediate the opioid inhibition or enhancement of evoked [5-methionine]enkephalin release. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1829501&form=6&db=m Different abilities of two types of Fc gamma receptor on guinea-pig macrophages to trigger the phosphatidylinositol turnover. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1829655&form=6&db=m T cell activation via the T cell receptor: a comparison between WT31 (defining alpha/beta TcR)-induced and anti-CD3-induced activation of human T lymphocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1831198&form=6&db=m Characterization of increased K+ permeability associated with the stimulation of receptors for immunoglobulin E on rat basophilic leukemia cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1831328&form=6&db=m Endothelin increases the synthesis and secretion of atrial natriuretic peptide in neonatal rat cardiocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1832018&form=6&db=m Membrane gangliosides modulate interleukin-2-stimulated T-lymphocyte proliferation. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1832710&form=6&db=m D1 dopamine receptors can interact with both stimulatory and inhibitory guanine nucleotide binding proteins. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1833985&form=6&db=m Prostaglandin E2 production in rat IMCD cells. I. Stimulation by dopamine. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1834545&form=6&db=m Adjuvanticity of pertussis toxin is mediated by differential effects on the activity of T suppressor, T amplifier and T helper cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1834672&form=6&db=m An intracellular guanine nucleotide release protein for G0. GAP-43 stimulates isolated alpha subunits by a novel mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1835388&form=6&db=m Requirement of ADP-ribosylation for the pertussis toxin-induced alteration in electrophoretic mobility of G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1835459&form=6&db=m A novel approach to detect toxin-catalyzed ADP-ribosylation in intact cells: its use to study the action of Pasteurella multocida toxin. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1835466&form=6&db=m Lysophosphatidylcholine induces mast cell secretion and protein kinase C activation. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1836187&form=6&db=m An abnormal signal transduction pathway in CD4-CD8- double-negative lymph node cells of MRL lpr/lpr mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1837558&form=6&db=m Induction of helper T cells by pertussis toxin during in vivo priming to insulin. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1839152&form=6&db=m Mechanisms involved in the interaction of dopamine with angiotensin II on aldosterone secretion in isolated and cultured rat adrenal glomerulosa cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1841959&form=6&db=m Regulation of spontaneous opening of muscarinic K+ channels in rabbit atrium. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1845801&form=6&db=m Glucose transport stimulation by bradykinin in Swiss 3T3 fibroblasts: a pertussis toxin-sensitive mechanism operates without involvement of arachidonic acid and cyclic AMP. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1845855&form=6&db=m Endothelin and increased contractility in adult rat ventricular myocytes. Role of intracellular alkalosis induced by activation of the protein kinase C-dependent Na(+)-H+ exchanger. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1845962&form=6&db=m High concentrations of a cGMP-stimulated phosphodiesterase mediate ANP-induced decreases in cAMP and steroidogenesis in adrenal glomerulosa cells. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1845968&form=6&db=m 5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1845988&form=6&db=m Mechanism of inhibition of adenylate cyclase by phospholipase C-catalyzed hydrolysis of phosphatidylcholine. Involvement of a pertussis toxin-sensitive G protein and protein kinase C. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1845999&form=6&db=m Receptor and G protein-mediated responses to thrombin in HEL cells. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1846220&form=6&db=m Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1846267&form=6&db=m Effects of adenosine on cAMP production and cytosolic Ca2+ in cultured rabbit medullary thick limb cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1846270&form=6&db=m Mechanisms of NE-induced reduction of Ca current in single smooth muscle cells from guinea pig vas deferens. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1846387&form=6&db=m Differences in signal transduction between Fc gamma receptors (Fc gamma RII, Fc gamma RIII) and FMLP receptors in neutrophils. Effects of colchicine on pertussis toxin sensitivity and diacylglycerol formation. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1846538&form=6&db=m Endothelin-3 stimulates production of endothelium-derived nitric oxide via phosphoinositide breakdown. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1846654&form=6&db=m Nucleotide responses of human neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1846880&form=6&db=m Disparate effects of interferon-gamma and tumor necrosis factor-alpha on early neutrophil respiratory burst and fungicidal responses to Candida albicans hyphae in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1846898&form=6&db=m Graded G-protein uncoupling by pertussis toxin treatment of human polymorphonuclear leukocytes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1847048&form=6&db=m The protective effect of atrial natriuretic peptide (ANP) on cells damaged by oxygen radicals is mediated through elevated CGMP-levels, reduction of calcium-inflow and probably G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1847195&form=6&db=m A functional assay to measure postsynaptic gamma-aminobutyric acidB responses in cultured spinal cord neurons: heterologous regulation of the same K+ channel. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1847209&form=6&db=m Effect of chronic D-Ala,2 D-Leu5-enkephalin or pertussis toxin treatment on the high-affinity state of delta opioid receptor in neuroblastoma x glioma NG108-15 hybrid cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,1,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1847497&form=6&db=m Alpha 2-adrenergic receptor stimulation of phospholipase A2 and of adenylate cyclase in transfected Chinese hamster ovary cells is mediated by different mechanisms. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1847683&form=6&db=m A clonal rat pancreatic delta cell line (Rin14B) expresses a high number of galanin receptors negatively coupled to a pertussis-toxin-sensitive cAMP-production pathway. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1847687&form=6&db=m Interaction of guanine-nucleotide-binding regulatory proteins with chemotactic peptide receptors in differentiated human leukemic HL-60 cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1847755&form=6&db=m Cell cycle-dependent coupling of the calcitonin receptor to different G proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1847868&form=6&db=m Activation of a pertussis-toxin-sensitive guanine-nucleotide-binding regulatory protein during desensitization of Dictyostelium discoideum cells to chemotactic signals. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848008&form=6&db=m Growth hormone inhibits activation of phosphatidylinositol phospholipase C in adipose plasma membranes: evidence for a growth hormone-induced change in G protein function. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848121&form=6&db=m Interaction of vascular alpha-1 adrenoceptors with multiple signal transduction pathways. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848191&form=6&db=m Activation of phospholipase D in rabbit neutrophils by fMet-Leu-Phe is mediated by a pertussis toxin-sensitive GTP-binding protein that may be distinct from a phospholipase C-regulating protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848199&form=6&db=m Mechanism of action of peptide YY to inhibit gastric motility. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848226&form=6&db=m Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848277&form=6&db=m Are several G proteins involved in the different effects of endothelin-1 in mouse striatal astrocytes? causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848278&form=6&db=m Potential mechanisms involved in the negative coupling between serotonin 5-HT1A receptors and carbachol-stimulated phosphoinositide turnover in the rat hippocampus. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848432&form=6&db=m Crystal-induced neutrophil activation. I. Initiation and modulation of calcium mobilization and superoxide production by microcrystals. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848657&form=6&db=m Transfected D2 dopamine receptors mediate the potentiation of arachidonic acid release in Chinese hamster ovary cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848752&form=6&db=m A pertussis-toxin-sensitive protein controls exocytosis in chromaffin cells at a step distal to the generation of second messengers. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848817&form=6&db=m Treatment of intact striatal neurones with cholera toxin or 8-bromoadenosine 3',5'-(cyclic)phosphate decreases the ability of pertussis toxin to ADP-ribosylate the alpha-subunits of inhibitory and other guanine-nucleotide-binding regulatory proteins, Gi and Go. Evidence for two distinct mechanisms. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848855&form=6&db=m Agonist-dependent, cholera toxin-catalyzed ADP-ribosylation of pertussis toxin-sensitive G-proteins following transfection of the human alpha 2-C10 adrenergic receptor into rat 1 fibroblasts. Evidence for the direct interaction of a single receptor with two pertussis toxin-sensitive G-proteins, Gi2 and Gi3. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1849101&form=6&db=m Involvement of G-proteins and adenylate cyclase in the action of gonad-stimulating substance on starfish ovarian follicle cells. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1849323&form=6&db=m Transduction of the modulatory effect of catecholamines at the mammalian motor neuron terminal. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1849366&form=6&db=m ANP stimulates phospholipase C in cultured RIMCT cells: roles of protein kinases and G protein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1849616&form=6&db=m Subcellular patterns of calcium release determined by G protein-specific residues of muscarinic receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1849644&form=6&db=m Transcription mediated by a cAMP-responsive promoter element is reduced upon activation of dopamine D2 receptors. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1849838&form=6&db=m Noradrenergic inhibition and voltage-dependent facilitation of omega-conotoxin-sensitive Ca channels in insulin-secreting RINm5F cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1849893&form=6&db=m Mechanisms of mastoparan-stimulated surfactant secretion from isolated pulmonary alveolar type 2 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1849937&form=6&db=m Activation of human neutrophils by Mycobacterium tuberculosis-derived sulfolipid-1. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1850120&form=6&db=m Identification of endothelin receptors in cultured cerebellar neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1850329&form=6&db=m Thrombin modulates phosphoinositide metabolism, cytosolic calcium, and impulse initiation in the heart. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1850381&form=6&db=m The role of G-protein in matrix-mediated motility of highly and poorly invasive melanoma cells. causal interaction,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1850467&form=6&db=m Pertussis toxin reduces endothelium-dependent and independent responses to alpha-2- adrenergic stimulation in systemic canine arteries and veins. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1850493&form=6&db=m Cholera toxin and pertussis toxin on opioid- and alpha 2-mediated supraspinal analgesia in mice. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1850738&form=6&db=m Protease treatment of pertussis toxin identifies the preferential cleavage of the S1 subunit. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1850750&form=6&db=m Multiple signal transduction pathways lead to extracellular ATP-stimulated mitogenesis in mammalian cells: II. A pathway involving arachidonic acid release, prostaglandin synthesis, and cyclic AMP accumulation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1850757&form=6&db=m A potential role for guanine nucleotide-binding protein in the regulation of endosomal proton transport. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1850760&form=6&db=m ATP receptor regulation of adenylate cyclase and protein kinase C activity in cultured renal LLC-PK1 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1851110&form=6&db=m Extracellular ATP itself elicits superoxide generation in guinea pig peritoneal macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1851206&form=6&db=m Muscarinic cholinergic receptor-mediated phosphoinositide metabolism in peripheral nerve. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1851836&form=6&db=m Neuromodulatory effect of the atrial natriuretic factor clearance receptor binding peptide, cANF(4-23)-NH2 in rabbit isolated vasa deferentia. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1855015&form=6&db=m Persistence of antibody after accelerated immunisation with diphtheria/tetanus/pertussis vaccine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1859428&form=6&db=m Pertussis toxin blocks melatonin-induced inhibition of forskolin-stimulated adenylate cyclase activity in the chick brain. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1860061&form=6&db=m Tricyclic antidepressants inhibit Ca(2+)-activated K(+)-efflux in cultured spinal cord neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1860634&form=6&db=m Mechanism for the gastrokinetic action of domperidone. In vitro studies in guinea pigs. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1861239&form=6&db=m Stimulatory effect of guanine nucleotides on prostaglandin E1 binding to murine renal outer medulla. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1864960&form=6&db=m Mast cell tryptase is a mitogen for cultured fibroblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1872850&form=6&db=m Type II phospholipase A2 recombinant overexpression enhances stimulated arachidonic acid release. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1874563&form=6&db=m An autocrine motility factor secreted by the Dunning R-3327 rat prostatic adenocarcinoma cell subtype AT2.1. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1875800&form=6&db=m Inhibition of hepatic adenylate cyclase by NADH. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1878227&form=6&db=m Cross-linking a maturation-dependent ram sperm plasma membrane antigen induces the acrosome reaction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1880156&form=6&db=m Effect of trifluoperazine on renal epithelioid Madin-Darby canine kidney cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1883372&form=6&db=m Transmembrane signalling by the N-formyl peptide receptor in stably transfected fibroblasts. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1883486&form=6&db=m Evidence for the involvement of multiple signalling pathways in C5a-induced actin polymerization and nucleation in human monocyte-like cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1884093&form=6&db=m Effect of pertussis pretreatment on plasma glucose and insulin responses to lithium in rats. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1888708&form=6&db=m The stimulation of lymphocyte motility by cultured high endothelial cells and its inhibition by pertussis toxin. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1892057&form=6&db=m Mechanisms of platelet activation: thromboxane A2 as an amplifying signal for other agonists. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1894354&form=6&db=m Contribution of the B oligomer to the protective activity of genetically attenuated pertussis toxin. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1894374&form=6&db=m Purification and characterization of the heat-labile toxin of Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1894382&form=6&db=m Comparison of pertussis toxin (PT)-neutralizing activities and mouse-protective activities of anti-PT mouse monoclonal antibodies. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1898104&form=6&db=m The influence of detergents on the availability of pertussis toxin substrates. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1898506&form=6&db=m Ischemia of rat brain decreases pertussis toxin-catalyzed [32P]ADP ribosylation of GTP-binding proteins (Gi1 and G0) in membranes. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1898968&form=6&db=m Sodium fluoride mimics the effect of prostaglandin E2 on catecholamine release from bovine adrenal chromaffin cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1899121&form=6&db=m Inhibition of endothelium-dependent relaxations by phorbol myristate acetate in canine coronary arteries: role of a pertussis toxin-sensitive G-protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1899345&form=6&db=m Role of pertussis toxin-sensitive guanosine triphosphate-binding proteins in the response of erythroblasts to erythropoietin. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1899403&form=6&db=m Evidence for the involvement of a pertussis toxin-insensitive G-protein in egg activation of the frog, Xenopus laevis. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1899485&form=6&db=m Purification of the active C5a receptor from human polymorphonuclear leukocytes as a receptor-Gi complex. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1899868&form=6&db=m Structural and functional studies of cross-linked Go protein subunits. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1900389&form=6&db=m A pertussis toxin-sensitive GTP-binding protein couples endothelin to phospholipase C in rat mesangial cells. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1900475&form=6&db=m Activation of protein kinase C inhibits hormonal stimulation of the GTPase activity of Gi in human platelets. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1900794&form=6&db=m Growth factor-induced cell division is paralleled by translocation of Gi alpha to the nucleus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1900833&form=6&db=m Cytosol promotes the guanine nucleotide-induced release of the alpha subunit of Gi2 from the membrane of mouse mastocytoma P-815 cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1901060&form=6&db=m Platelet-activating factor induces tyrosine phosphorylation in human neutrophils. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1901617&form=6&db=m Computer modelling of the NAD binding site of ADP-ribosylating toxins: active-site structure and mechanism of NAD binding. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1901939&form=6&db=m Directed shift of fatty acids from phospholipids to triacylglycerols in HL-60 cells induced by nanomolar concentrations of triethyl lead chloride: involvement of a pertussis toxin-sensitive pathway. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1902093&form=6&db=m Identification of the G-protein alpha-subunit encoded by alpha o2 cDNA as a 39 kDa pertussis toxin substrate. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1902170&form=6&db=m Dopamine inhibits inositol phosphate production, arachidonic acid formation, and corticosteroid release by frog adrenal gland through a pertussis toxin-sensitive G-protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1902575&form=6&db=m Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1903490&form=6&db=m ADP-ribosylation of G proteins with pertussis toxin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1903550&form=6&db=m Pertussis toxin blocks the dipsogenic actions of carbachol, but does not block the dipsogenic and pressor actions of angiotensin II. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1903697&form=6&db=m Protein kinase C activation mimics but does not mediate thyrotropin-induced desensitization of adenylyl cyclase in cultured dog thyroid cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1903700&form=6&db=m Aluminum-induced mitogenesis in MC3T3-E1 osteoblasts: potential mechanism underlying neoosteogenesis. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1903796&form=6&db=m Cellular mechanisms of ATP-induced hyperpolarization in renal epitheloid MDCK-cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1904224&form=6&db=m Non-steroidal anti-inflammatory drugs: effects on a GTP binding protein within the neutrophil plasma membrane. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1904382&form=6&db=m The 20 kDa C-terminally truncated form of pertussis toxin subunit S1 secreted from Bacillus subtilis. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1904910&form=6&db=m Detection of G proteins in purified bovine brain myelin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1904963&form=6&db=m Inhibition of acetylcholine release from guinea pig myenteric neurons by neuropeptide Y: GTP-binding protein mediation. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1905225&form=6&db=m The function but not the expression of rat liver inhibitory guanine nucleotide binding protein is altered in streptozotocin-induced diabetes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1905330&form=6&db=m Regulation of phospholipase D and primary granule secretion by P2-purinergic- and chemotactic peptide-receptor agonists is induced during granulocytic differentiation of HL-60 cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1905569&form=6&db=m Rapid activation of phosphatidate phosphohydrolase in mesangial cells by lipid A. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1905731&form=6&db=m Identification of two novel GTP-binding protein alpha-subunits that lack apparent ADP-ribosylation sites for pertussis toxin. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1905812&form=6&db=m G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1905813&form=6&db=m G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1906007&form=6&db=m Effects of lithium ion on ADP ribosylation of inhibitory GTP-binding protein by pertussis toxin, islet-activating protein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1906273&form=6&db=m Direct activation of GTP-binding proteins by venom peptides that contain cationic clusters within their alpha-helical structures. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1906389&form=6&db=m Bovine pituitary, kidney, uterine and mammary gland extracts contain bovine mammary epithelium growth factors that synergise with IGF-I and fetal calf serum: indication for involvement of GTP-binding proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1906710&form=6&db=m Failure of [32P]ADP-ribosylation by pertussis toxin to determine Gi alpha content in membranes from various human tissues. Improved radioimmunological quantification using the 125I-labelled C-terminal decapeptide of retinal transducin. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1906890&form=6&db=m Resolution of a low molecular weight G protein in neutrophil cytosol required for NADPH oxidase activation and reconstitution by recombinant Krev-1 protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1907001&form=6&db=m Distinct cellular expression of pertussis toxin-sensitive GTP-binding proteins in rat cerebellum. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1907102&form=6&db=m Smooth muscle adenosine A1 receptors couple to disparate effectors by distinct G proteins in pregnant myometrium. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1907213&form=6&db=m Possible role for G-proteins in behavioral sensitization to cocaine. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1907493&form=6&db=m Characterization of cytosolic pertussis toxin-sensitive GTP-binding protein in mastocytoma P-815 cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1907563&form=6&db=m Inhibition of prolactin secretion by endothelin-3 is pertussis toxin-sensitive. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1907582&form=6&db=m Immunocytochemical and biochemical characterization of guanine nucleotide-binding regulatory proteins in mammalian spermatozoa. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1907720&form=6&db=m Adenosine receptors mediate a pertussis toxin-insensitive prejunctional inhibition of noradrenaline release on a papillary muscle model. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1907726&form=6&db=m Inhibition of pertussis toxin catalyzed ADP-ribosylation of G-proteins by membrane depolarization in rat brain synaptoneurosomes. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1907989&form=6&db=m Microfilament assembly is required for antigen-receptor-mediated activation of human B lymphocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1908364&form=6&db=m Effects of calcium on light-activated GTP-binding proteins in squid photoreceptor membranes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1908548&form=6&db=m Inhibitory GTP-binding regulatory protein Gi3 can couple angiotensin II receptors to inhibition of adenylyl cyclase in hepatocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1908559&form=6&db=m Sensitization to cocaine produced by injection of pertussis toxin into the A10 dopamine region. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1908572&form=6&db=m Calcitonin-gene-related peptide activates the muscarinic-gated K+ current in atrial cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1908646&form=6&db=m Developmental changes in adenylyl cyclase and GTP binding proteins in brown fat. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1908689&form=6&db=m Signal transduction in human alveolar macrophages: diminished chemotactic response to FMLP correlates with a diminished density of Gi proteins and FMLP receptors. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1908786&form=6&db=m Mast cell degranulating (MCD) peptide and its optical isomer activate GTP binding protein in rat mast cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1908788&form=6&db=m Widespread distribution of Gq alpha/G11 alpha detected immunologically by an antipeptide antiserum directed against the predicted C-terminal decapeptide. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1908825&form=6&db=m Effect of site-directed mutagenic alterations on ADP-ribosyltransferase activity of the A subunit of Escherichia coli heat-labile enterotoxin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1908837&form=6&db=m Pertussis toxin-induced mitogenesis in human T lymphocytes. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1909527&form=6&db=m Pertussis and cholera toxins inhibit prostaglandin synthesis in rat astrocyte cultures at distinct metabolic steps. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1909767&form=6&db=m Immunogenicity and protective efficacy of pertussis toxin subunit S1 produced by Bacillus subtilis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1910049&form=6&db=m A heterotrimeric G protein, G alpha i-3, on Golgi membranes regulates the secretion of a heparan sulfate proteoglycan in LLC-PK1 epithelial cells. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1910333&form=6&db=m Asymmetrical distribution of G-proteins among the apical and basolateral membranes of rat enterocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1912521&form=6&db=m Tumor cell motility. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1915878&form=6&db=m Presence of phospholipase C in coated vesicles from bovine brain. Dual regulatory effects of GTP-analogs. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1916613&form=6&db=m The uterotonic action of the aqueous extract of Bridelia atroviridis in the rat. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1918957&form=6&db=m The signal transduction pathway involved in the migration induced by a monocyte chemotactic cytokine. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1920385&form=6&db=m Assembly and sealing of tight junctions: possible participation of G-proteins, phospholipase C, protein kinase C and calmodulin. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1921983&form=6&db=m GTP-binding protein G alpha Z: its down-regulation by dexamethasone and its credentials as a mediator of antigen-induced responses in RBL-2H3 cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1928448&form=6&db=m Regulation of ATP-dependent surfactant secretion and activation of second-messenger systems in alveolar type II cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1929409&form=6&db=m Purification and characterization of a GTP-binding protein serving as pertussis toxin substrate in starfish oocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1929874&form=6&db=m The oxime HGG-12 as a muscarinic acetylcholine receptor antagonist without intrinsic activity in cardiac membranes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1930168&form=6&db=m Signal transduction in Coprinus congregatus: evidence for the involvement of G proteins in blue light photomorphogenesis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1930187&form=6&db=m Synthesis and characterization of a Pertussis toxin-biotin conjugate. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1930847&form=6&db=m Hyperactivation of phospholipase C does not support the enhanced proliferation of aortic smooth muscle cells from spontaneously hypertensive rats. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1931159&form=6&db=m Enhancement of differentiation of rat adipocyte precursor cells by pertussis toxin. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1931484&form=6&db=m The transduction signalling protein Go during embryonic development of Drosophila melanogaster. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1933276&form=6&db=m Pertussis toxin potentiates seizures induced by pilocarpine, kainic acid and N-methyl-D-aspartate. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1934339&form=6&db=m Effects of neuropeptide Y on cell length and membrane currents in isolated guinea pig ventricular myocytes. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1935791&form=6&db=m The effects of endothelins on the secretion of prolactin, luteinizing hormone, and follicle-stimulating hormone are mediated by different guanine nucleotide-binding proteins. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1935970&form=6&db=m Ca2+ ionophore A23187 and thrombin inhibit the pertussis-toxin-induced ADP-ribosylation of the alpha-subunit of the inhibitory guanine-nucleotide-binding protein and other proteins in human platelets. causal interaction,diagnostic usage,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1936256&form=6&db=m Possible involvement of GTP-binding proteins in growth regulation of human epidermoid carcinoma cell line A431. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1936946&form=6&db=m The melanophore aggregating response of isolated fish scales: a very rapid and sensitive diagnosis of whooping cough. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1937784&form=6&db=m Site-specific mutagenesis of the catalytic subunit of cholera toxin: substituting lysine for arginine 7 causes loss of activity. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1937835&form=6&db=m Properties of the B oligomer of pertussis toxin. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1939086&form=6&db=m Expression of a G protein subunit, alpha i-1, in Balb/c 3T3 cells leads to agonist-specific changes in growth regulation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1941636&form=6&db=m Sensitization to psychostimulants and stress after injection of pertussis toxin into the A10 dopamine region. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1942080&form=6&db=m Immunodetectable levels of the inhibitory guanine nucleotide-binding regulatory proteins in failing human heart: discordance with measurements of adenylate cyclase activity and levels of pertussis toxin substrate. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1944236&form=6&db=m Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5'-nucleotide receptor in human airway epithelial cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1944306&form=6&db=m Effect of ras-gene transformation on the inhibition of NIH3T3 cell growth by pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1944610&form=6&db=m Terminal serotonin autoreceptor function in the rat hippocampus is not modified by pertussis and cholera toxins. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1944613&form=6&db=m Biphasic dose-response curves to arecoline in rat atria-mediation by a single promiscuous receptor or two receptor subtypes? ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1944614&form=6&db=m Interactions of intracerebroventricular pertussis toxin treatment with the ataxic and hypothermic effects of ethanol. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1945605&form=6&db=m Differences in antibody response to whole-cell pertussis vaccines. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1945748&form=6&db=m Further analysis of ATP-mediated activation of K+ channels in renal epithelioid Madin Darby canine kidney (MDCK) cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1946421&form=6&db=m Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1950101&form=6&db=m Detoxification of Bordetella pertussis organisms or pertussis toxin with glutaraldehyde for preparation of pertussis vaccine. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1950278&form=6&db=m [The standardization of the in-vitro tetanus toxin neutralization test on Chinese hamster ovary cells] diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1951767&form=6&db=m Oxygen pressure-dependent control of carbonic anhydrase synthesis in chick embryonic erythrocytes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1953275&form=6&db=m [Activation mechanisms by thrombin and vasopressin of fibroblasts in spontaneously hypertensive rats] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1953712&form=6&db=m Identification of proteins resembling G-protein alpha subunits in locust muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1957276&form=6&db=m Activation-independent exposure of the GPIIb-IIIa fibrinogen receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1959944&form=6&db=m Cytokines inhibit proliferation and insulin secretion by clonal rat insulinoma cells (RINm5F) non-synergistically and in a pertussis toxin-insensitive manner. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1960420&form=6&db=m The lymphocytosis promoting action of pertussis toxin can be mimicked in vitro. Holotoxin but not the B subunit inhibits invasion of human T lymphoma cells through fibroblast monolayers. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1962846&form=6&db=m Regulation of the amiloride-blockable sodium channel from epithelial tissue. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1963152&form=6&db=m Pharmacological characterization of phosphoinositide-linked glutamate receptor excitation of hippocampal neurons. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1963319&form=6&db=m Involvement of protein kinase A in the regulation of intracellular free calcium and phosphoinositide turnover in rat myometrium. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1963337&form=6&db=m Mobilization of intracellular Ca2+ and suppression of inward currents in a neuronal hybrid cell line triggered by bradykinin. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1963397&form=6&db=m In vitro effects of 17 beta-oestradiol on the sensitivity of receptors coupled to adenylate cyclase on striatal neurons in primary culture. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1963568&form=6&db=m The reduction of neuronal calcium currents by ATP-gamma-S is mediated by a G protein and occurs independently of cyclic AMP-dependent protein kinase. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1963570&form=6&db=m Mechanism of the cardiovascular effects of GABAB receptor activation in the nucleus tractus solitarii of the rat. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1964091&form=6&db=m Epidermal growth factor-induced phosphoinositide hydrolysis in permeabilized 3T3 cells: lack of guanosine triphosphate dependence and inhibition by tyrosine-containing peptides. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1964390&form=6&db=m Leukotriene D4 induced calcium changes in U937 cells may utilize mechanisms additional to inositol phosphate production that are pertussis toxin insensitive but are blocked by phorbol myristate acetate. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1965330&form=6&db=m The interaction of adenosine analogues with cAMP-generating and cAMP-independent positive inotropic agents in rabbit left atrium. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1965516&form=6&db=m Enhancement in beta-adrenergic responsiveness of adenylate cyclase in rat liver during regeneration after carbon tetrachloride administration. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1965652&form=6&db=m Stimulation of a histone H4 protein kinase in Triton X-100 lysates of rabbit peritoneal neutrophils pretreated with chemotactic factors: lack of requirements of calcium mobilization and protein kinase C activation. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1966023&form=6&db=m Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1966371&form=6&db=m Regulation by bradykinin of phosphoinositide metabolism in the endothelial cells of the pulmonary artery. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1966374&form=6&db=m Myocardial beta-adrenoceptors and inhibitory G-proteins in myocardial biopsies and in explanted hearts from patients with dilated cardiomyopathy. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1966603&form=6&db=m Messengers mediating long-term desensitization in cerebellar Purkinje cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1966810&form=6&db=m Tumor necrosis factor alpha 'primes' the platelet-activating factor-induced superoxide production by human neutrophils: possible involvement of G proteins. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1967144&form=6&db=m Evidence that receptor-linked G protein inhibits exocytosis by a post-second-messenger mechanism in AtT-20 cells. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1967538&form=6&db=m Effects of tiazofurin on guanine nucleotide binding regulatory proteins in HL-60 cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1967818&form=6&db=m Amplification of cyclic AMP generation reveals agonistic effects of certain beta-adrenergic antagonists. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1968910&form=6&db=m Complex regulation of calcium current in cardiac cells. Dependence on a pertussis toxin-sensitive substrate, adenosine triphosphate, and an alpha 1-adrenoceptor. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1968926&form=6&db=m Interactions between a lymphoma membrane-associated guanosine 5'-triphosphate-binding protein and the cytoskeleton during receptor patching and capping. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1969353&form=6&db=m Effects of pertussis toxin on inhibition of synaptosomal tyrosine hydroxylase activity by apomorphine. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1969470&form=6&db=m Effect of pertussis toxin on the interaction of azepexole and halothane. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1969967&form=6&db=m Effect of atriopeptin II on Ca influx, contractile behavior and cyclic nucleotide content of cultured neonatal rat myocardial cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1970605&form=6&db=m Potassium conductance increased by noradrenaline, opioids, somatostatin, and G-proteins: whole-cell recording from guinea pig submucous neurons. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1970637&form=6&db=m Glutamate receptors activate Ca2+ mobilization and Ca2+ influx into astrocytes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1970731&form=6&db=m Pertussis toxin does not inhibit alpha 1-adrenergic potentiation of beta-adrenergic stimulation of cyclic AMP accumulation in rat pinealocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1970828&form=6&db=m Inhibition of basal and corticotropin-releasing hormone-stimulated adenylate cyclase activity and cytosolic Ca2+ levels by somatostatin in human corticotropin-secreting pituitary adenomas. diagnostic usage,ongoing research,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1972138&form=6&db=m Norepinephrine release and neuropeptide Y in medulla oblongata of spontaneously hypertensive rats. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1972864&form=6&db=m Functionally distinct muscarinic receptors on gastric somatostatin cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1972902&form=6&db=m Potent and cooperative feedback inhibition of adenylate cyclase activity by calcium in pituitary-derived GH3 cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1973119&form=6&db=m Gi proteins and calcium in dynorphin-induced hypothermia and behaviour. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1973537&form=6&db=m Adrenoceptor-activation of oxygen consumption in rat parotid acini. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1974396&form=6&db=m Pertussis toxin and 4-aminopyridine differentially affect the hypnotic-anesthetic action of dexmedetomidine and pentobarbital. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1974662&form=6&db=m Clonidine inhibits fluid absorption in the rabbit proximal convoluted renal tubule. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1974763&form=6&db=m Effects of alpha 2-adrenergic agonist preincubation on subsequent forskolin-stimulated adenylate cyclase activity and [3H]forskolin binding in membranes from HT29 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1975238&form=6&db=m Fimbrial phase variation in Bordetella pertussis: a novel mechanism for transcriptional regulation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1975627&form=6&db=m Agonist interaction with alkylation-sensitive and -resistant alpha-1 adrenoceptor subtypes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1976205&form=6&db=m Mechanisms for muscarinic inhibition of somatostatin release from canine fundic D cells. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1976209&form=6&db=m Gastric somatostatin: a paracrine regulator of acid secretion. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1976250&form=6&db=m Dynorphin A and cAMP-dependent protein kinase independently regulate neuronal calcium currents. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1976303&form=6&db=m Coupling of adenosine A1 receptors to a G-protein in coated vesicles isolated from bovine brain: presence of pertussis and cholera toxin substrates. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1976633&form=6&db=m Identification of somatostatin receptors by covalent labeling with a novel photoreactive somatostatin analog. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1976700&form=6&db=m Evidence that a receptor-operated event on the neutrophil mediates neutrophil accumulation in vivo. Pretreatment of 111In-neutrophils with pertussis toxin in vitro inhibits their accumulation in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,1,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1976755&form=6&db=m Maitotoxin induces phosphoinositide turnover and modulates glutamatergic and muscarinic cholinergic receptor function in cultured cerebellar neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1976802&form=6&db=m Two types of voltage-dependent calcium current in rat somatotrophs are reduced by somatostatin. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1977676&form=6&db=m [Noradrenaline-induced alterations in beta-adrenergic receptor-adenylate cyclase system of rat myocardium] therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1978342&form=6&db=m GABA-induced potassium channels in cultured neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1978729&form=6&db=m Neuromodulatory effects of atrial natriuretic factor are independent of guanylate cyclase in adrenergic neuronal pheochromocytoma cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1978791&form=6&db=m A guanine nucleotide-binding protein mediates the inhibition of voltage-dependent calcium currents by dopamine in rat lactotrophs. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1978837&form=6&db=m Identification and partial characterization of genes that are transactivated by different pathways in quiescent mouse cells stimulated with serum. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1979294&form=6&db=m Receptor-mediated regulation of calcium channels and neurotransmitter release. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1979512&form=6&db=m The anti-adrenergic effect of adenosine and its blockade by pertussis toxin: a comparative study in myocytes isolated from guinea-pig, rat and failing human hearts. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1980000&form=6&db=m Description of a hybridoma bank towards Bordetella pertussis toxin and surface antigens. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1980264&form=6&db=m Divergent regulation of beta 2-adrenoceptors and adenylate cyclase in the Cyc- mouse T lymphoma cell line TL2-9. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1980742&form=6&db=m Selective coupling of different muscarinic acetylcholine receptors to neuronal calcium currents in DNA-transfected cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1981169&form=6&db=m Effects of pertussis toxin on caudate neuron electrophysiology: studies with dopamine D1 and D2 agonists. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1981365&form=6&db=m Differential coupling with pertussis toxin-sensitive G proteins of dopamine and somatostatin receptors involved in regulation of adenohypophyseal secretion. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1981560&form=6&db=m Stimulation of the T-cell receptors CD3 and CD2 with OKT3 and OKT11 antibodies activates a common pertussis toxin-insensitive G-protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1981685&form=6&db=m Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1981953&form=6&db=m ADP-ribosylation of cerebrocortical synaptosomal proteins by cholera, pertussis and botulinum toxins. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1982458&form=6&db=m Somatostatin acts through G-proteins on dopaminergic adenylate cyclase in the caudate-putamen of the rat. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1982527&form=6&db=m Functional maturation of somatostatin neurons and somatostatin receptors during development of mouse hypothalamus in vivo and in vitro. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1983121&form=6&db=m Inhibition of calcium currents by noradrenaline, somatostatin and opioids in guinea-pig submucosal neurones. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1983122&form=6&db=m Mechanisms underlying presynaptic inhibition through alpha 2-adrenoceptors in guinea-pig submucosal neurones. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1983124&form=6&db=m Intracellular mechanisms for alpha 1-adrenergic regulation of the transient outward current in rabbit atrial myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1985936&form=6&db=m Regulation of transmembrane signal transduction of insulin-like growth factor II by competence type growth factors or viral ras p21. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1990017&form=6&db=m Activation of cell membrane potassium conductance by mercury in cultured renal epithelioid (MDCK) cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1990137&form=6&db=m Assay of Bordetella pertussis heat-labile toxin with human embryonic lung cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1991383&form=6&db=m Loss of endothelial pertussis toxin-sensitive G protein function in atherosclerotic porcine coronary arteries. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1993675&form=6&db=m Localization of a region of the S1 subunit of pertussis toxin required for efficient ADP-ribosyltransferase activity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1993991&form=6&db=m Allosteric interactions at the m1, m2 and m3 muscarinic receptor subtypes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1995729&form=6&db=m Immune responses to Bordetella pertussis infection and vaccination. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1997420&form=6&db=m Further analysis of the sequence of the S1 subunit of pertussis toxin. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2001240&form=6&db=m Cellular mechanisms of adrenaline-induced hyperpolarization in renal epitheloid MDCK cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2004818&form=6&db=m Ammonium decreases human polymorphonuclear leukocyte cytoskeletal actin. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2009269&form=6&db=m Differential effects of pertussis toxin on insulin-stimulated phosphatidylcholine hydrolysis and glycerolipid synthesis de novo. Studies in BC3H-1 myocytes and rat adipocytes. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2010815&form=6&db=m Kappa- and delta-opioids block sympathetically dependent hyperalgesia. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2015619&form=6&db=m Calcium inhibition of cardiac adenylyl cyclase. Evidence for two distinct sites of inhibition. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2015814&form=6&db=m Characterization of fMet-Leu-Phe-stimulated phospholipase C in streptolysin-O-permeabilised cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2017195&form=6&db=m Structural and functional analysis of the S1 subunit of pertussis toxin using synthetic peptides. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2017196&form=6&db=m A novel process for preparing an acellular pertussis vaccine composed of non-pyrogenic toxoids of pertussis toxin and filamentous hemagglutinin. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2019753&form=6&db=m Evaluation of serology and nasopharyngeal cultures for diagnosis of pertussis in a vaccine efficacy trial. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2021948&form=6&db=m The relationship between motility factor receptor internalization and the lung colonization capacity of murine melanoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2022702&form=6&db=m Multiple signal transduction pathways lead to extracellular ATP-stimulated mitogenesis in mammalian cells: I. Involvement of protein kinase C-dependent and -independent pathways. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2022924&form=6&db=m Integrin-mediated localization of Bordetella pertussis within macrophages: role in pulmonary colonization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2026225&form=6&db=m Seroepidemiology of pertussis infection in an urban childhood population in Cameroon. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2026251&form=6&db=m Biphasic kinetics of inositol 1,4,5-trisphosphate accumulation in gastrin-stimulated parietal cells. Effects of pertussis toxin and extracellular calcium. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2035630&form=6&db=m Progesterone inhibits K conductance in plasma membrane of cultured renal epitheloid MDCK cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2036919&form=6&db=m Pertussis toxin effects on chemoattractant-induced response heterogeneity in human PMNs utilizing Fluo-3 and flow cytometry. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2039936&form=6&db=m Modification of morphine-induced analgesia and toxicity by pertussis toxin. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2040054&form=6&db=m Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2040692&form=6&db=m Shape changes, exocytosis, and cytosolic free calcium changes in stimulated human eosinophils. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2043665&form=6&db=m Evidence for the presence of P2-purinoceptors at the surface of human articular chondrocytes in monolayer culture. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2049177&form=6&db=m A sensitive method for measuring neutralizing antibodies to Bordetella pertussis toxin: optimized ADP-ribosylation of transducin. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2049399&form=6&db=m Studies on the mechanism of uptake of low density lipoprotein-proteoglycan complex in macrophages. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2049405&form=6&db=m The role of intracellular acidification in calcium mobilization in human neutrophils. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2050151&form=6&db=m A spectroscopic and conformational study of pertussis toxin. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2050404&form=6&db=m A 23-kilodalton protein, distinct from BvgA, expressed by virulent Bordetella pertussis binds to the promoter region of vir-regulated toxin genes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2050675&form=6&db=m Characterization of the m4 muscarinic receptor Ca2+ response in a subclone of PC-12 cells by single cell flow cytometry. Inhibition of the response by bradykinin. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2052747&form=6&db=m Early PDGF-induced alterations in cytosolic free calcium are required for mitogenesis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2058603&form=6&db=m A comparative trial of the reactogenicity and immunogenicity of Takeda acellular pertussis vaccine combined with tetanus and diphtheria toxoids. Outcome in 3- to 8-month-old infants, 9- to 23-month-old infants and children, and 24- to 30-month-old children. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2060641&form=6&db=m Change of intracellular calcium of neural cells induced by extracellular ATP. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2061319&form=6&db=m Rapid release of bound glucose-6-phosphate dehydrogenase by growth factors. Correlation with increased enzymatic activity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2061848&form=6&db=m Mechanisms underlying intracellular signal transduction of the slow IPSP in submucous neurones of the guinea-pig caecum. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2062628&form=6&db=m Booster response to acellular pertussis vaccine in children primed with acellular or whole cell vaccines. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2068192&form=6&db=m Pertussis toxin pretreatment affects opiate/nonopiate and stress-induced analgesia differently. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2071590&form=6&db=m Calcium changes in immune complex-stimulated human neutrophils. Simultaneous measurement of receptor occupancy and activation reveals full population stimulus binding but subpopulation activation. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2075771&form=6&db=m [The development of a new generation of pertussis vaccine] therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2081095&form=6&db=m Possible involvement of protein kinase C and cyclic AMP-dependent protein kinase in the sodium fluoride-mediated inhibition of cyclic nucleotide accumulation in smooth muscle cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2084543&form=6&db=m [Structural organization of a segment of chromosome, containing the vir gene of Bordetella pertussis] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2089270&form=6&db=m Alteration of the GTP-dependent inhibitory pathway of rat striatal adenylate cyclase by phorbol esters. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2091609&form=6&db=m Sympathetic--parasympathetic interaction and sudden death. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2092999&form=6&db=m Promiscuous or heterogeneous muscarinic receptors in rat atria? I. Schild analysis with simple competitive antagonists. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2093000&form=6&db=m Promiscuous or heterogeneous muscarinic receptors in rat atria? II. Antagonism of responses to carbachol by pirenzepine. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2104880&form=6&db=m Neuropeptide Y and peptide YY inhibit lipolysis in human and dog fat cells through a pertussis toxin-sensitive G protein. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2105104&form=6&db=m Stimulus-response coupling in FMLP-stimulated U937 monocytes: effect of differentiation on Gi2 expression. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2105204&form=6&db=m In vivo pertussis toxin administration: effects on the function and levels of Gi alpha proteins and their messenger ribonucleic acids. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2105321&form=6&db=m Gz, a guanine nucleotide-binding protein with unique biochemical properties. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2105325&form=6&db=m Thrombin-induced prostacyclin biosynthesis in human endothelium: role of guanine nucleotide regulatory proteins in stimulus/coupling responses. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2105379&form=6&db=m Multiple GTP-binding proteins from cholinergic synaptic vesicles. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2105889&form=6&db=m Pertussis toxin and H-7 distinguish mechanisms involved in eicosanoid release from lipopolysaccharide-primed macrophages. Eicosanoid release from lipopolysaccharide-primed macrophages. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2106149&form=6&db=m Chronic morphine administration and in vivo pertussis toxin treatment induce hyperalgesia and enhance 3H-nitrendipine binding. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2106433&form=6&db=m Involvement of distinct G-proteins in the action of vasopressin on rat glomerulosa cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2106487&form=6&db=m Activation of the respiratory burst in murine phagocytes by certain guanine ribonucleosides modified at the 7 and 8 positions: possible involvement of a pertussis toxin-sensitive G-protein. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2106571&form=6&db=m G protein control of potassium channel activity in a mast cell line. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2106877&form=6&db=m Hepoxilin A3 induces changes in cytosolic calcium, intracellular pH and membrane potential in human neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2107277&form=6&db=m Neuroblastoma differentiation involves the expression of two isoforms of the alpha-subunit of Go. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2107404&form=6&db=m Intracerebroventricular treatment of mice with pertussis toxin induces hyperalgesia and enhances 3H-nitrendipine binding to synaptic membranes: similarity with morphine tolerance. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2107759&form=6&db=m [Ca2+]i rises via G protein during regulatory volume decrease in rabbit proximal tubule cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2108051&form=6&db=m A 43 kDa form of the GTP-binding protein Gi3 in human erythrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2108094&form=6&db=m Biochemical and biological activities of recombinant S1 subunit of pertussis toxin. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2108158&form=6&db=m Distinct guanine nucleotide binding and release properties of the three Gi proteins. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2108162&form=6&db=m Epidermal growth factor enhances glomerular mesangial cell soluble phospholipase A2 activity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2108170&form=6&db=m Down-regulation of Gi sub-types by prolonged incubation of adipocytes with an A1 adenosine receptor agonist. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2108197&form=6&db=m TRH raises cytosolic Ca2+ in human adenomatous lactotrophs. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2108211&form=6&db=m Neutrophil activation by inflammatory microcrystals of monosodium urate monohydrate utilizes pertussis toxin-insensitive and -sensitive pathways. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2108675&form=6&db=m Pertussis toxin inhibits EGF-, phorbol ester- and insulin-stimulated DNA synthesis in BALB/c3T3 cells: evidence for post-receptor activation of Gi alpha. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2108693&form=6&db=m Rhodopsin expressed in Chinese hamster ovary cells regulates adenylyl cyclase activity. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2108729&form=6&db=m Two distinct light regulated G-proteins in octopus photoreceptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2109044&form=6&db=m Guanine nucleotide-binding protein regulation of microsomal phospholipase D activity of canine cerebral cortex. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2109182&form=6&db=m Non-steady state kinetic analysis of the regulation of adenylate cyclase by GTP-binding proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2109291&form=6&db=m Melatonin modulates diacylglycerol and arachidonic acid metabolism in the anterior pituitary of immature rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2109319&form=6&db=m Involvement of GTP-binding proteins in actin polymerization in human neutrophils. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2109684&form=6&db=m Direct neuropeptide Y-induced modulation of gonadotrope intracellular calcium transients and gonadotropin secretion. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2109694&form=6&db=m A Go-like protein in Drosophila melanogaster and its expression in memory mutants. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2109707&form=6&db=m Pertussis toxin-mediated ADP-ribosylation of rabbit luteal Gi uncouples enkephalin inhibition of adenylyl cyclase. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2110066&form=6&db=m Pertussis toxin inhibits endothelium-dependent relaxations evoked by fluoride. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2110091&form=6&db=m Production and secretion of pertussis toxin subunits in Bacillus subtilis. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2110418&form=6&db=m Ligand binding and G protein coupling of muscarinic receptors in airway smooth muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2110913&form=6&db=m Pertussis toxin-catalyzed ADP-ribosylation of a G protein in mouse oocytes, eggs, and preimplantation embryos: developmental changes and possible functional roles. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2111013&form=6&db=m 2-Azido-[32P]NAD+, a photoactivatable probe for G-protein structure: evidence for holotransducin oligomers in which the ADP-ribosylated carboxyl terminus of alpha interacts with both alpha and gamma subunits. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2111319&form=6&db=m A prostaglandin E receptor coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rabbit cortical collecting tubule cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2111695&form=6&db=m Tumor necrosis factor induced release of endothelial cell lipoprotein lipase. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2112511&form=6&db=m Regulation of cytosolic calcium by angiotensins in vascular smooth muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2113368&form=6&db=m The development of physiologic responsiveness to muscarinic stimulation in embryonic chick heart. Relationship to increased levels of pertussis toxin substrates. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2113525&form=6&db=m Modification of plasma membrane protein cysteine residues by ADP-ribose in vivo. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2113531&form=6&db=m Molecular cloning of a novel splice variant of the alpha subunit of the mammalian Go protein. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2113768&form=6&db=m Human neutrophil stimulation by influenza virus: relationship of cytoplasmic pH changes to cell activation. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2114093&form=6&db=m Hormonal regulation of Gi2 alpha-subunit phosphorylation in intact hepatocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2114177&form=6&db=m Involvement of a guanine-nucleotide-binding protein-mediated mechanism in the enhancement of arachidonic acid liberation by phorbol 12-myristate 13-acetate and Ca2+ in saponin-permeabilized platelets. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2114479&form=6&db=m Fluoride produces endothelium-dependent relaxation and endothelium-independent contraction in coronary artery. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2114480&form=6&db=m Developmental changes in the muscarinic stimulation of canine Purkinje fibers. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2115427&form=6&db=m Growth factor-like action of lysophosphatidic acid: mitogenic signalling mediated by G proteins. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2115432&form=6&db=m Differences in the actions of calcium versus lanthanum to influence parathyroid hormone release. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2115550&form=6&db=m A neutrophil GTP-binding protein that regulates cell free NADPH oxidase activation is located in the cytosolic fraction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2115889&form=6&db=m Characterization of the human gene for Gx alpha, a pertussis toxin-insensitive regulatory GTP-binding protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2116341&form=6&db=m Membrane-associated 41-kDa GTP-binding protein in collagen-induced platelet activation. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2116797&form=6&db=m Mastoparan, a wasp venom, activates platelets via pertussis toxin-sensitive GTP-binding proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2116927&form=6&db=m Identification of the pertussis toxin-sensitive G proteins in platelets, megakaryocytes, and human erythroleukemia cells. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2116998&form=6&db=m Heterogeneity of the motility responses in malignant tumor cells: a biological basis for the diversity and homing of metastatic cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2117248&form=6&db=m Interaction of purified bovine brain A1-adenosine receptors with guanine nucleotide-binding proteins of human platelet membranes following reconstitution. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2117441&form=6&db=m Cholecystokinin activates Gi1-, Gi2-, Gi3- and several Gs-proteins in rat pancreatic acinar cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2117569&form=6&db=m Up-regulation of human neutrophil receptors for Neisseria gonorrhoeae expressing PII outer membrane proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2118147&form=6&db=m Pertussis toxin catalyzed ADP-ribosylation of a 41 kDa G-protein impairs insulin-stimulated glucose metabolism in BC3H-1 myocytes. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2118385&form=6&db=m Altered responses to modulators of guanine nucleotide binding protein activity in endotoxin tolerance. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2118390&form=6&db=m [Identification and purification of GTP-binding regulatory proteins from plasma membranes of swine heart] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2118762&form=6&db=m Possible involvement of different GTP-binding proteins in noradrenaline- and thrombin-stimulated release of arachidonic acid in rabbit platelets. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2118945&form=6&db=m Pretreatment of mouse striatal neurons in primary culture with 17 beta-estradiol enhances the pertussis toxin-catalyzed ADP-ribosylation of G alpha o,i protein subunits. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2119232&form=6&db=m Fluoride-mediated activation of the respiratory burst in electropermeabilized neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2119237&form=6&db=m Thrombin induces c-fos expression in cultured human endothelial cells by a Ca2(+)-dependent mechanism. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2119344&form=6&db=m Pertussis toxin analog with reduced enzymatic and biological activities is a protective immunogen. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2119477&form=6&db=m Mechanism of N-formyl-methionyl-leucyl-phenylalanine- and platelet-activating factor-induced arachidonic acid release in guinea pig alveolar macrophages: involvement of a GTP-binding protein and role of protein kinase A and protein kinase C. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2120208&form=6&db=m Activation of Na+/Ca2+ exchange by adenosine in ewe heart sarcolemma is mediated by a pertussis toxin-sensitive G protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2120213&form=6&db=m Purification from bovine liver membranes of a guanine nucleotide-dependent activator of phosphoinositide-specific phospholipase C. Immunologic identification as a novel G-protein alpha subunit. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2120237&form=6&db=m Purification of unique alpha subunits of GTP-binding regulatory proteins (G proteins) by affinity chromatography with immobilized beta gamma subunits. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2120283&form=6&db=m Endothelin enhances the contractile responsiveness of adult rat ventricular myocytes to calcium by a pertussis toxin-sensitive pathway. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2120702&form=6&db=m Proximal tubular epithelial cells possess a novel 42-kilodalton guanine nucleotide-binding regulatory protein. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2121142&form=6&db=m Isolation of three types of Gi from bovine spleen. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2121366&form=6&db=m G alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit complex interactions. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2121510&form=6&db=m Pertussis toxin-sensitive G-proteins in the sino-atrial node and right atrium of bovine heart. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2121565&form=6&db=m Differential regulation of G protein subunit expression in mouse oocytes, eggs, and early embryos. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2121960&form=6&db=m ATP regulates muscarine-sensitive potassium current in dissociated bull-frog primary afferent neurones. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2122563&form=6&db=m G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2122640&form=6&db=m G-proteins and phospholipase activation in endothelial cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2122744&form=6&db=m Different activation of L-arginine pathway by bradykinin, serotonin, and clonidine in coronary arteries. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2122887&form=6&db=m Muscarinic cholinergic stimulation of inositol phosphate production in cultured embryonic chick atrial cells. Evidence for a role of two guanine-nucleotide-binding proteins. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2122888&form=6&db=m Development of muscarinic-cholinergic stimulation of inositol phosphate production in cultured embryonic chick atrial cells. Evidence for a switch in guanine-nucleotide-binding protein coupling. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2122922&form=6&db=m G-proteins and endothelial responses. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2123451&form=6&db=m Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2123511&form=6&db=m Purification of pertussis toxin substrates from bovine heart membranes. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2123549&form=6&db=m G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2123822&form=6&db=m Lymphocyte receptors for pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2123967&form=6&db=m G-proteins are involved in contractile responses of isolated mesenteric resistance arteries to agonists. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2123985&form=6&db=m Relaxation of bovine mesenteric arteries by glyceryl trinitrate and other nitro-compounds: evidence for partly different mechanisms of action. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2124115&form=6&db=m Cross-linking of G-proteins to the prolactin receptor in rat NB2 lymphoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2124805&form=6&db=m Receptor-linked early events induced by vasoactive intestinal contractor (VIC) on neuroblastoma and vascular smooth-muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2124806&form=6&db=m Light-dependent GTP-binding proteins in squid photoreceptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2124929&form=6&db=m Evidence against a role for a pertussis toxin-sensitive G protein in Ca2+ mobilization in rat parotid acinar cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2124930&form=6&db=m Involvement of a pertussis toxin-sensitive G protein in the action of gastrin on gastric parietal cells. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2124972&form=6&db=m Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2125219&form=6&db=m Diacylglycerol production induced by growth hormone in Ob1771 preadipocytes arises from phosphatidylcholine breakdown. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2125225&form=6&db=m dgq: a drosophila gene encoding a visual system-specific G alpha molecule. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2125461&form=6&db=m Influence of dietary omega-3 fatty acids on transmembrane signalling in rat submandibular salivary gland. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2126223&form=6&db=m Evidence for a pertussis toxin-sensitive signalling pathway in the dual action of angiotensin II on growth hormone release in pituitary cell aggregates. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2127736&form=6&db=m Changes of ADP-ribosylation of GTP-binding protein by pertussis toxin in human platelets during long-term treatment of manic depression with lithium carbonate. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2128428&form=6&db=m Immunogenicity of glutaraldehyde inactivated pertussis vaccine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2128430&form=6&db=m Expression of pertussis toxin subunit S4 as an intracytoplasmic protein in Bacillus subtilis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2129194&form=6&db=m Mitogenic signaling pathways of growth factors can be distinguished by the involvement of pertussis toxin-sensitive guanosine triphosphate-binding protein and of protein kinase C. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2129222&form=6&db=m Signal transduction of a tissue interaction during embryonic heart development. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2129393&form=6&db=m Effect of bacterial toxins on spermine-induced inhibition of adenylate cyclase activity of cultured heart cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2132531&form=6&db=m Pertussis toxin-sensitive and -insensitive mechanisms for diacylglycerol-protein kinase C signalling during insulin action in BC3H-1 myocytes. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2133288&form=6&db=m Modulation of the priming effects of platelet-activating factor on the release of interleukin-1 from lipopolysaccharide-stimulated rat spleen macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2136995&form=6&db=m Physical evidence of the coupling of solubilized 5-HT1A binding sites with G regulatory proteins. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2137824&form=6&db=m Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2138520&form=6&db=m TPA induction of EL4 resistance to macrophage-released TNF: role of ADP-ribosylation in tumoricidal activities of TNF and other factors. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2139307&form=6&db=m Endorphin suppresses FSH-stimulated proliferation of isolated neonatal Sertoli cells by a pertussis toxin-sensitive mechanism. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2139456&form=6&db=m On the mechanism of action of dexamethasone in a rat mast cell line (RBL-2H3 cells). Evidence for altered coupling of receptors and G-proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2141022&form=6&db=m Glucagon-(19-29) exerts a biphasic action on the liver plasma membrane Ca2+ pump which is mediated by G proteins. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2141573&form=6&db=m Effect of bacterial toxins on human B cell activation. I. Mitogenic activity of pertussis toxin. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2141600&form=6&db=m Mechanism of action of GTP in the induction of Ca2+ release from hepatic microsomes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2144700&form=6&db=m Biosynthesis and functions of leukotriene C4. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2145396&form=6&db=m Possible involvement of pertussis toxin-sensitive G proteins and D2 dopamine receptors in the A1 adenosine receptor-adenylate cyclase system in rat cerebral cortex. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2148087&form=6&db=m Enhancement of bradykinin-induced prostacyclin synthesis in porcine aortic endothelial cells by pertussis toxin. Possible implication of lipocortin I. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2152372&form=6&db=m Involvement of pertussis toxin sensitive GTP binding protein in adenosine triphosphate and thrombin-mediated responses in vascular smooth muscle cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2152880&form=6&db=m A novel extracellular nucleotide receptor coupled to phosphoinositidase-C in pituitary cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2152883&form=6&db=m Angiotensin II stimulates angiotensinogen synthesis in hepatocytes by a pertussis toxin-sensitive mechanism. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2152941&form=6&db=m Pertussis toxin inhibits the FMLP-induced membrane association of protein kinase C in human neutrophils. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153030&form=6&db=m Characterization of influenza A virus activation of the human neutrophil. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153051&form=6&db=m Identification of B16-F1 melanoma autocrine motility-like factor receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153515&form=6&db=m Regulation of 1,2-diacylglycerol production by angiotensin-II in bovine adrenal glomerulosa cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153536&form=6&db=m Thrombin stimulates inositol phosphate production and intracellular free calcium by a pertussis toxin-insensitive mechanism in osteosarcoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153573&form=6&db=m Effects of pertussis toxin on alpha 1-agonist-mediated phosphatidylinositide turnover and myocardial cell hypertrophy in neonatal rat ventricular myocytes. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153575&form=6&db=m Agonist-sensitive binding of a photoreactive GTP analog to a G-protein alpha-subunit in membranes of HL-60 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153579&form=6&db=m Mastoparan inhibits phosphoinositide hydrolysis via pertussis toxin-insensitive [corrected] G-protein in human astrocytoma cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153580&form=6&db=m Carbamylcholine inhibits beta-adrenergic receptor-coupled Gs protein function proximal to adenylate cyclase. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153673&form=6&db=m A novel mechanism of action of corticotropin releasing factor in rat Leydig cells. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153688&form=6&db=m Distinct pathways regulate transforming growth factor beta 1-stimulated proto-oncogene and extracellular matrix gene expression. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153754&form=6&db=m mu-Opioid receptors and not kappa-opioid receptors are coupled to the adenylate cyclase in the cerebellum. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153771&form=6&db=m G protein is coupled to presynaptic glutamate and GABA receptors in lobster neuromuscular synapse. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153802&form=6&db=m Pertussis toxin inhibits contractions but not endothelium-dependent relaxations of rabbit pulmonary artery in response to acetylcholine and other agonists. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2154131&form=6&db=m Mechanisms leading to adenosine-stimulated proliferation of microvascular endothelial cells. causal interaction,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2154202&form=6&db=m Tumor necrosis factor-alpha/cachectin activates the O2(-)-generating system of human neutrophils independently of the hydrolysis of phosphoinositides and the release of arachidonic acid. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2154219&form=6&db=m Autocrine motility factor stimulates a three-fold increase in inositol trisphosphate in human melanoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2154281&form=6&db=m GABAB receptor activation inhibits Ca2(+)-activated 86Rb-efflux in cultured spinal cord neurons via G-protein mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2154370&form=6&db=m Cellular distribution and biochemical characterization of G proteins in skeletal muscle: comparative location with voltage-dependent calcium channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2154471&form=6&db=m Interleukin-1 signal transduction. Increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4). ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2154661&form=6&db=m Cyclic AMP content and invasive capacity of metastatic variants of the BW-5147 murine T-cell lymphoma. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2154969&form=6&db=m Cholera toxin modulation of angiotensin II-stimulated inositol phosphate production in cultured vascular smooth muscle cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2155099&form=6&db=m The role of G-proteins in the mitogenesis of rat lactogen-dependent and lactogen-independent Nb2 lymphoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2155182&form=6&db=m Monoclonal antibodies that inhibit ADP-ribosyltransferase but not NAD-glycohydrolase activity of pertussis toxin. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2155214&form=6&db=m The epidermal growth factor receptor is coupled to a phospholipase A2-specific pertussis toxin-inhibitable guanine nucleotide-binding regulatory protein in cultured rat inner medullary collecting tubule cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2155220&form=6&db=m Histamine-stimulated and GTP-binding proteins-mediated phospholipase A2 activation in rabbit platelets. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2155232&form=6&db=m The role of cysteine 41 in the enzymatic activities of the pertussis toxin S1 subunit as investigated by site-directed mutagenesis. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2155364&form=6&db=m Effects of pertussis toxin on vasodilation and cyclic GMP in bovine mesenteric arteries and demonstration of a 40 kD soluble protein ribosylation substrate for pertussis toxin. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2155382&form=6&db=m Pertussis toxin inhibits cAMP-induced desensitization of adenylate cyclase in Dictyostelium discoideum. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2155922&form=6&db=m Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2155963&form=6&db=m Functional activation of human neutrophils by recombinant monocyte-derived neutrophil chemotactic factor/IL-8. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2156016&form=6&db=m Alpha 1-adrenergic receptor mediates arachidonic acid release in spinal cord neurons independent of inositol phospholipid turnover. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2156056&form=6&db=m Activation of muscarinic cholinergic receptors in mouse neuroblastoma x rat glioma hybrid cells: rapid induction of enhanced capacity of prostaglandin E1 receptors to stimulate cyclic AMP accumulation. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2156116&form=6&db=m Altered phosphatidylinositol breakdown after K-elastin stimulation in PMNLs of elderly. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2156152&form=6&db=m Spontaneous association between opioid receptors and GTP-binding regulatory proteins in native membranes: specific regulation by antagonists and sodium ions. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2156444&form=6&db=m Effects of epidermal growth factor on signal transduction in rabbit parietal cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2156499&form=6&db=m Inhibition of mink lung epithelial cell proliferation by transforming growth factor-beta is coupled through a pertussis-toxin-sensitive substrate. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2156637&form=6&db=m Pertussis toxin treatment of whole blood. A novel approach to assess G protein function in congestive heart failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2156669&form=6&db=m Stimulatory effect of insulin and insulin-like growth factor I on Gi proteins and angiotensin-II-induced phosphoinositide breakdown in cultured bovine adrenal cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2156892&form=6&db=m Epidermal growth factor-stimulated phosphoinositide hydrolysis in cultured rat inner medullary collecting tubule cells. Regulation by G protein, calcium, and protein kinase C. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2156895&form=6&db=m The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2156932&form=6&db=m Functional maturation of human T lymphocytes is accompanied by changes in the G-protein pattern. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2157429&form=6&db=m IL1 induces proliferation and IL6 mRNA expression in a human astrocytoma cell line: positive and negative modulation by chorela toxin and cAMP. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2157433&form=6&db=m A high-affinity bradykinin receptor in membranes from rat myometrium is coupled to pertussis toxin-sensitive G-proteins of the Gi family. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2157711&form=6&db=m Endothelin mobilizes Ca2+ from a caffeine- and ryanodine-insensitive intracellular pool in rat atrial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2157853&form=6&db=m Functional uncoupling of the inhibitory alpha 1-adrenergic response from a G-protein in innervated cultured cardiac cells by K+ depolarization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2157961&form=6&db=m Regulation by GTP and its stable thiol derivatives of calcium current components in rat nodose ganglion neurons. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2158424&form=6&db=m Activin-A modulates growth hormone secretion from cultures of rat anterior pituitary cells. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2158431&form=6&db=m Stimulation of luteinizing hormone release by sodium fluoride is independent of protein kinase-C activity and unaffected by desensitization to gonadotropin-releasing hormone. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2158546&form=6&db=m Molecular mechanisms of homologous desensitization and internalization of muscarinic receptors in primary cultures of neonatal corticostriatal neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2158555&form=6&db=m Pharmacological differentiation of angiotensin effects in the rabbit isolated vas deferens with dithiothreitol and pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159022&form=6&db=m Effect of thrombin on calcium homeostasis in chick embryonic heart cells. Receptor-operated calcium entry with inositol trisphosphate and a pertussis toxin-sensitive G protein as second messengers. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159096&form=6&db=m A pertussis toxin resistant alpha 2-adrenoceptor pathway in fish melanophores. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159104&form=6&db=m Serum antibody response to B. pertussis Tn5 mutants, purified PT and FHA in two different mouse strains and passive protection in the murine intranasal infection model. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159294&form=6&db=m Comparative studies of phosphoinositide hydrolysis induced by endothelin-related peptides in cultured cerebellar astrocytes, C6-glioma and cerebellar granule cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159454&form=6&db=m A GTP-binding protein activates chloride channels in a renal epithelium. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159473&form=6&db=m Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159482&form=6&db=m Functional coupling of the alpha 2-adrenergic receptor-adenylate cyclase complex in the pregnant human myometrium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159512&form=6&db=m Comparison of stimulation by chemotactic formyl peptide analogs between GTPase activity in neutrophil plasma membranes and granule enzyme release from intact neutrophils. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159759&form=6&db=m Pertussis toxin in the analysis of receptor mechanisms. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159762&form=6&db=m Functional expression of the human receptor for colony-stimulating factor 1 (CSF-1) in hamster fibroblasts: CSF-1 stimulates Na+/H+ exchange and DNA-synthesis in the absence of phosphoinositide breakdown. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159800&form=6&db=m Lipid and membrane interactions of neuropeptide Y. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159978&form=6&db=m N-acetylation of serotonin is correlated with alpha 2- but not with beta-adrenergic regulation of cyclic AMP levels in cultured chick pineal cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2160028&form=6&db=m Cholera and pertussis exotoxins protect mice against the lethal Schwartzman reaction and antagonize the effects of lipopolysaccharide on second messenger systems. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2160057&form=6&db=m Serotonin-2 receptors coupled to phosphoinositide hydrolysis in a clonal cell line. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2160237&form=6&db=m Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2160368&form=6&db=m Pertussis toxin modifies the effect of central morphine on rat intestinal motility. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2160462&form=6&db=m Ring-deleted analogs of atrial natriuretic factor inhibit adenylate cyclase/cAMP system. Possible coupling of clearance atrial natriuretic factor receptors to adenylate cyclase/cAMP signal transduction system. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2160813&form=6&db=m Quantification of the alpha and beta subunits of the transducing elements (Gs and Gi) of adenylate cyclase in adipocyte membranes from lean and obese (ob/ob) mice. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2160868&form=6&db=m 5-Hydroxytryptamine induces phospholipase C-mediated hydrolysis of phosphoinositides through 5-hydroxytryptamine-2 receptors in cultured fetal mouse ventricular myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2161088&form=6&db=m A mechanism additional to cyclic AMP accumulation for vasoactive intestinal peptide-induced prolactin release. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2161218&form=6&db=m Insulin-like growth factor-II/mannose 6-phosphate receptor is incapable of activating GTP-binding proteins in response to mannose 6-phosphate, but capable in response to insulin-like growth factor-II. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2161892&form=6&db=m Lymphotoxin induces secretion of granule proteins from adherent neutrophils: possible role of intracellular free calcium. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2162060&form=6&db=m Evidence that a guanine nucleotide-binding protein linked to a muscarinic receptor inhibits directly phospholipase C. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2162072&form=6&db=m Cytochalasin-induced nitroblue tetrazolium dye (NBT) reduction in polymorphonuclear leukocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2162138&form=6&db=m Influence of anti-beta-receptor antibodies on cardiac adenylate cyclase in patients with idiopathic dilated cardiomyopathy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2162218&form=6&db=m Pertussis toxin pretreatment reveals differential effects of adenosine analogs on IgE-dependent histamine and peptidoleukotriene release from RBL-2H3 cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2162279&form=6&db=m Attenuation of the low-density-lipoprotein-activated phosphoinositide signalling system by calcium blockers in human lymphocytes. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2162345&form=6&db=m Differential coupling of dopaminergic D2 receptors expressed in different cell types. Stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis in LtK- fibroblasts, hyperpolarization, and cytosolic-free Ca2+ concentration decrease in GH4C1 cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2162356&form=6&db=m Differential activation of the stimulatory and inhibitory guanine nucleotide-binding proteins by fluoroaluminate in cells and in membranes. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2162376&form=6&db=m Cannabinoid receptors and modulation of cyclic AMP accumulation in the rat brain. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2162842&form=6&db=m Cellular responses to stimulation of the M5 muscarinic acetylcholine receptor as seen in murine L cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2162850&form=6&db=m Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2162851&form=6&db=m Studies on the cell-cycle dependency of the actions of insulin-like growth factor-I in Balb/c 3T3 cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2163017&form=6&db=m Pharmacological characterization of the adenylate cyclase-coupled adenosine receptor in isolated guinea pig atrial myocytes. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2163038&form=6&db=m Dopamine (D2) or gamma-aminobutyric acid (GABAB) receptor activation hyperpolarizes rat melanotrophs and pertussis toxin blocks these responses and the accompanying fall in [Ca2+]i. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2163277&form=6&db=m Adrenergic-cholinergic interactions in left atria: a study using K+ channel agonists, antagonist and pertussis toxin. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2163325&form=6&db=m Removal of partial agonism from parathyroid hormone (PTH)-related protein-(7-34)NH2 by substitution of PTH amino acids at positions 10 and 11. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2163326&form=6&db=m Treatment of bone-derived ROS 17/2.8 cells with dexamethasone and pertussis toxin enables detection of partial agonist activity for parathyroid hormone antagonists. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2163336&form=6&db=m Protein kinase C and Gi-protein mediated modulation of cAMP production in different stages of the rat seminiferous epithelium. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2163626&form=6&db=m Interleukin (IL)-8-induced in vitro human lymphocyte migration is inhibited by cholera and pertussis toxins and inhibitors of protein kinase C. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2163743&form=6&db=m Insulin sensitizes a cultured rat osteogenic sarcoma cell line to hormones which activate adenylate cyclase. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2163856&form=6&db=m Pertussis toxin differentiates between alpha 1- and alpha 2-adrenoceptor-mediated inhibition of noradrenaline release from rat kidney cortex. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2163886&form=6&db=m Evidence for receptor-mediated inhibition of intrinsic activity of GTP-binding protein, Gi1 and Gi2, but not G0 in reconstitution experiments. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2164008&form=6&db=m Guanosine 5'-O-(3-thiotriphosphate) and guanosine 5'-O-(2-thiodiphosphate) activate G proteins and potentiate fibroblast growth factor-induced DNA synthesis in hamster fibroblasts. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2164062&form=6&db=m Monoclonal anti-CD23 antibodies induce a rise in [Ca2+]i and polyphosphoinositide hydrolysis in human activated B cells. Involvement of a Gp protein. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2164067&form=6&db=m Identification of a 43-kilodalton human T lymphocyte membrane protein as a receptor for pertussis toxin. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2164475&form=6&db=m Inhibitory effects of pertussis toxin on the cAMP generating system in human mononuclear leucocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2164554&form=6&db=m Activation of the superoxide-generating NADPH oxidase of macrophages by sodium dodecyl sulfate in a soluble cell-free system: evidence for involvement of a G protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2164571&form=6&db=m Characterization of functional neuropeptide Y receptors in a human neuroblastoma cell line. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2164927&form=6&db=m Follicle-stimulating hormone receptor-mediated uptake of 45Ca2+ by cultured rat Sertoli cells does not require activation of cholera toxin- or pertussis toxin-sensitive guanine nucleotide binding proteins or adenylate cyclase. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2165202&form=6&db=m Role for cyclic AMP in the postreceptor control of cytokine-stimulated stromal cell growth factor production. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2165355&form=6&db=m Modulation of vasopressin antidiuretic action by renal alpha 2-adrenoceptors. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2165808&form=6&db=m Polarized 86Rb+ effluxes in primary cultures of rabbit kidney proximal cells: role of calcium and hypotonicity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2165838&form=6&db=m No effect of pertussis toxin on peripheral prejunctional alpha 2-adrenoceptor-mediated responses and on endothelium-dependent relaxations in the rat. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2166534&form=6&db=m Short-term regulation of Na+,K(+)-ATPase activity by dopamine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2166688&form=6&db=m G protein control of inositol lipids in intact vascular smooth muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2166901&form=6&db=m Effects of sulfhydryl-modifying reagents, 3-nitro-2-pyridinesulfenyl compounds, on the coupling between inhibitory receptors and GTP-binding proteins Gi/Go in rat brain membranes. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2166906&form=6&db=m Pertussis toxin inhibits norepinephrine-stimulated inositol phosphate formation in primary brain cell cultures. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2167204&form=6&db=m A comparison of the effects of divalent and trivalent cations on parathyroid hormone release, 3',5'-cyclic-adenosine monophosphate accumulation, and the levels of inositol phosphates in bovine parathyroid cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2167220&form=6&db=m Dopamine inhibits two characterized voltage-dependent calcium currents in identified rat lactotroph cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2167969&form=6&db=m Whole-cell calcium current in guinea-pig ventricular myocytes dialysed with guanine nucleotides. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2168471&form=6&db=m Tumor necrosis factor-mediated biological activities involve a G-protein-dependent mechanism. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2168817&form=6&db=m Mechanism of cytokine inhibition of beta-adrenergic agonist stimulation of cyclic AMP in rat cardiac myocytes. Impairment of signal transduction. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2168897&form=6&db=m Growth and protein phosphorylation in the Nb2 lymphoma: effect of prolactin, cAMP, and agents that activate adenylate cyclase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2168918&form=6&db=m Characterization of human phagocytic cell receptors for C5A and platelet activating factor expressed in Xenopus oocytes. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2168919&form=6&db=m Fc gamma receptor-mediated functions in neutrophils are modulated by adenosine receptor occupancy. A1 receptors are stimulatory and A2 receptors are inhibitory. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2169284&form=6&db=m Pertussis toxin B-subunit-induced Ca2(+)-fluxes in Jurkat human lymphoma cells: the action of long-term pre-treatment with cholera and pertussis holotoxins. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2169285&form=6&db=m Extracellular ATP stimulates polyphosphoinositide hydrolysis and prostaglandin synthesis in rat renal mesangial cells. Involvement of a pertussis toxin-sensitive guanine nucleotide binding protein and feedback inhibition by protein kinase C. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2169286&form=6&db=m Desensitization of vasopressin sensitive adenylate cyclase by vasopressin and phorbol esters. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2169312&form=6&db=m Subcellular distribution and characterization of GTP-binding proteins in human neutrophils. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2169357&form=6&db=m Increase of Gi alpha in human hearts with dilated but not ischemic cardiomyopathy. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2169363&form=6&db=m Pertussis toxin attenuates angiotensin II but not beta-adrenoceptor facilitation of noradrenaline release from rat kidney cortex. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2169531&form=6&db=m Effects of follicle stimulating hormone, cholera toxin, pertussis toxin and forskolin on adenosine cyclic 3',5'-monophosphate output by granulosa cells from Booroola ewes with or without the F gene. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2169571&form=6&db=m Alpha-bag cell peptide inhibits bag cell adenylate cyclase via a GTP-dependent mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2169576&form=6&db=m Direct coupling of the somatostatin receptor to potassium channels by a G protein. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2169897&form=6&db=m Multiple pathways for signal transduction in the regulation of arachidonic acid metabolism in rat peritoneal macrophages. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2170382&form=6&db=m Receptor-operated calcium influx in rat hepatocytes. Identification and characterization using manganese. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2170389&form=6&db=m Agonist stimulation of Na+/K+/Cl- cotransport in rat glomerular mesangial cells. Evidence for protein kinase C-dependent and Ca2+/calmodulin-dependent pathways. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2170406&form=6&db=m Two distinct pathways of platelet-activating factor-induced hydrolysis of phosphoinositides in primary cultures of rat Kupffer cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2170410&form=6&db=m Neuropeptide Y stimulation of myosin light chain phosphorylation in cultured aortic smooth muscle cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2170530&form=6&db=m Soluble and insoluble immune complexes activate human neutrophil NADPH oxidase by distinct Fc gamma receptor-specific mechanisms. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2170558&form=6&db=m Evidence that the action of calcitonin on rat osteoclasts is mediated by two G proteins acting via separate post-receptor pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2170634&form=6&db=m Muscarinic modulation of calcium current in neurones from the interatrial septum of bull-frog heart. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2171361&form=6&db=m Interaction of adenosine with vasopressin in the inner medullary collecting duct. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2171509&form=6&db=m Involvement of pertussis toxin-sensitive GTP-binding protein in prostaglandin F2 alpha- induced phosphoinositide hydrolysis in osteoblast-like cells. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2171511&form=6&db=m Receptor-mediated action of hepoxilin A3 releases diacylglycerol and arachidonic acid from human neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2171803&form=6&db=m Enhanced alpha 1-adrenergic responsiveness in cardiomyopathic hamster cardiac myocytes. Relation to the expression of pertussis toxin-sensitive G protein and alpha 1-adrenergic receptors. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2171846&form=6&db=m Sensitization of human alpha 1- and alpha 2-adrenergic venous responses by guanadrel sulfate. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2171947&form=6&db=m Are GABAB receptors involved in the pharmacological effects of ethanol? unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2172240&form=6&db=m A novel guanine nucleotide-binding protein coupled to the alpha 1-adrenergic receptor. II. Purification, characterization, and reconstitution. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2172264&form=6&db=m Simultaneous determination of Bordetella pertussis toxin and filamentous haemagglutinin concentrations by hydroxyapatite high-performance liquid chromatography. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2172343&form=6&db=m Adenylate cyclase system in fetal rat keratinizing epidermal cells (FRSK cells) and SV40-transformed human keratinocytes. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2172355&form=6&db=m Prejunctional beta-adrenoceptors, angiotensin II and neuropeptide Y receptors on sympathetic nerves in mouse atria are linked to N-ethylmaleimide-susceptible G-proteins. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2172674&form=6&db=m Amplification of the rat M2 muscarinic receptor gene by the polymerase chain reaction: functional expression of the M2 muscarinic receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2172767&form=6&db=m Delineation of muscarinic receptor domains conferring selectivity of coupling to guanine nucleotide-binding proteins and second messengers. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2172773&form=6&db=m Characterization of adenosine A1 receptors in intact DDT1 MF-2 smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2172862&form=6&db=m Stimulation of hypothalamic opioid peptide release by lithium is mediated by opioid autoreceptors: evidence from a combined in vitro, ex vivo study. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2173411&form=6&db=m PT pretreatment inhibits 48/80-induced activation of Ca(+)-permeable channels in rat peritoneal mast cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2173720&form=6&db=m Noncoordinate regulation of alpha-1 adrenoreceptor coupling and reexpression of alpha skeletal actin in myocardial infarction-induced left ventricular failure in rats. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2173926&form=6&db=m Pertussis toxin inhibits alpha 2-adrenoceptor-mediated inhibition of adenylate cyclase without affecting muscarinic regulation of [Ca2+]i or inositol phosphate generation in SH-SY5Y human neuroblastoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2173982&form=6&db=m Specific alpha 1-adrenergic receptor subtypes modulate catecholamine-induced increases and decreases in ventricular automaticity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2174064&form=6&db=m Signal transduction in N-formyl-methionyl-leucyl-phenylalanine and concanavalin A stimulated human neutrophils: superoxide production without a rise in intracellular free calcium. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2174348&form=6&db=m Follicle-stimulating hormone evokes an increase in intracellular free calcium ion concentrations in single ovarian (granulosa) cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2174431&form=6&db=m Leukotriene D4 and E4 induce transmembrane signaling in human epithelial cells. Single cell analysis reveals diverse pathways at the G-protein level for the influx and the intracellular mobilization of Ca2+. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2174674&form=6&db=m Reovirus transport--studies using lymphocytosis promoting factor. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2174693&form=6&db=m Selective coupling of purified alpha-subunits of pertussis toxin-substrate GTP-binding proteins to endogenous receptors in rat brain membranes treated with N-ethylmaleimide. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2174773&form=6&db=m Involvement of pertussis-toxin-sensitive G protein in muscarinic-receptor-mediated inhibition of K(+)-activated 4-nitrophenylphosphatase activity of cardiac sarcolemma. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2174803&form=6&db=m Carbachol mimics phorbol esters in its ability to enhance cyclic GMP production by STa, the heat-stable toxin of Escherichia coli. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2175054&form=6&db=m Pertussis toxin inhibition of anti-immunoglobulin-stimulated proliferation and inositol phosphate formation. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2175347&form=6&db=m Mechanism of acetylcholine-induced inhibition of Ca current in bullfrog atrial myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2175562&form=6&db=m Effect of transforming growth factor-alpha and parathyroid hormone-related protein on phosphate transport in renal cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2175564&form=6&db=m Alpha 2-adrenergic receptors regulate Na(+)-H+ exchange via a cAMP-dependent mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2175853&form=6&db=m Modulation of neuronal T-type calcium channel currents by photoactivation of intracellular guanosine 5'-O(3-thio) triphosphate. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2175913&form=6&db=m Activation of early events of the mitogenic response by a P2Y purinoceptor with covalently bound 3'-O-(4-benzoyl)-benzoyladenosine 5'-triphosphate. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2176162&form=6&db=m Inhibition of endothelin-mediated topoisomerase I activation by pertussis toxin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2176213&form=6&db=m Strong and persistent activation of inositol lipid breakdown induces early mitogenic events but not Go to S phase progression in hamster fibroblasts. Comparison of thrombin and carbachol action in cells expressing M1 muscarinic acetylcholine receptors. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2176464&form=6&db=m Comparison of extracellular ATP and UTP signalling in rat renal mesangial cells. No indications for the involvement of separate purino- and pyrimidino-ceptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2176473&form=6&db=m G-protein-mediated regulation of the insulin-responsive glucose transporter in isolated cardiac myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2176498&form=6&db=m Alpha-adrenoceptor activation of polyphosphoinositide hydrolysis in the rat tail artery. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2176527&form=6&db=m Mitigation of beta 1- and/or beta 2-adrenoceptor function in human heart failure. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2176801&form=6&db=m Involvement of a pertussis toxin-sensitive G protein in the regulation of angiotensinogen production by an angiotensin II analog in HepG2 cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2176832&form=6&db=m Insulin activates glycerol-3-phosphate acyltransferase (de novo phosphatidic acid synthesis) through a phospholipid-derived mediator. Apparent involvement of Gi alpha and activation of a phospholipase C. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2177517&form=6&db=m Role of guanine nucleotide binding protein, cytosolic calcium and cAMP in fluoride-induced suppression of PTH secretion. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2177627&form=6&db=m A cAMP independent inhibitory action of high doses of forskolin in rat Leydig cells. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2180488&form=6&db=m Effects of insulin on inositol phosphate production in cultured rat hepatocytes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2182017&form=6&db=m Endothelin-1 stimulates the release of preloaded [3H]D-aspartate from cultured cerebellar granule cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2187055&form=6&db=m Astrocytes are target cells for endothelins and sarafotoxin. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2190618&form=6&db=m The influence of K(+)-induced membrane depolarization on insulin secretion in islets of lean and obese (ob/ob) mice. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2194485&form=6&db=m Paradoxes of pertussis toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2196173&form=6&db=m Colony-stimulating factor 1 activates protein kinase C in human monocytes. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2201750&form=6&db=m Metabolic, humoral, and cellular responses in adult volunteers immunized with the genetically inactivated pertussis toxin mutant PT-9K/129G. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2204620&form=6&db=m Pertussis toxin produces differential inhibitory effects on basal, P2-purinergic, and chemotactic peptide-stimulated inositol phospholipid breakdown in HL-60 cells and HL-60 cell membranes. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2211659&form=6&db=m The subunit S1 is important for pertussis toxin secretion. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2221065&form=6&db=m Dual modulation by adenosine of gastrin release from canine G-cells in primary culture. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2225081&form=6&db=m Mechanisms of pertussis toxin inhibition of lymphocyte-HEV interactions. I. Analysis of lymphocyte homing receptor-mediated binding mechanisms. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2226651&form=6&db=m Correlation between chemotactic peptide-induced changes in chlorotetracycline fluorescence and F-actin content in human neutrophils: a role for membrane-associated calcium in the regulation of actin polymerization? therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2228237&form=6&db=m Engineering of genetically detoxified pertussis toxin analogs for development of a recombinant whooping cough vaccine. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2229283&form=6&db=m Regulation of intracellular free calcium in human myometrial cells by prostaglandin F2 alpha: comparison with oxytocin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2234097&form=6&db=m The effects of ageing on prejunctional 5-hydroxytryptamine receptors in the rat vas deferens. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2235142&form=6&db=m Serologic evidence of subclinical pertussis in immunized children. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2244906&form=6&db=m Comparison of the lectin-like activity of pertussis toxin with two plant lectins that have differential specificities for alpha (2-6) and alpha (2-3)-linked sialic acid. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2253703&form=6&db=m Muscarinic acetylcholine receptors in the sino-atrial node and right atrium of bovine heart. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2254024&form=6&db=m Production of tumor necrosis factors alpha and beta by human mononuclear leukocytes stimulated with mitogens, bacteria, and malarial parasites. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2254030&form=6&db=m Mechanism of pertussis toxin B oligomer-mediated protection against Bordetella pertussis respiratory infection. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2254036&form=6&db=m Effects of recombinant human interleukin-1 beta on accumulation of inflammatory peritoneal macrophages in mice treated with pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2257129&form=6&db=m Antibody response to pertussis toxin and filamentous haemagglutinin in NIH mice immunized with the International Standard for Pertussis Vaccine. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2257130&form=6&db=m Acellular and whole cell pertussis vaccines protect against the lethal effects of intracerebral challenge by two different T-cell dependent humoral routes. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2265696&form=6&db=m The inhibition by pertussis and tetanus toxins of evoked catecholamine release from intact and permeabilized bovine adrenal chromaffin cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2274108&form=6&db=m The effect of oxiferriscorbone on striatal adenylate cyclase of the rat. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2277349&form=6&db=m Intracellular regulation of enzyme secretion from rat osteoclasts and evidence for a functional role in bone resorption. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2282501&form=6&db=m Blockade of morphine analgesia by both pertussis and cholera toxins in the periaqueductal gray and locus coeruleus. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2283955&form=6&db=m Hemagglutination activities of purified pertussis toxin and filamentous hemagglutinin against erythrocytes from various animals. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2285502&form=6&db=m The effect of amphiphilic polymers on growth of Bordetella pertussis and production of B. pertussis haemagglutinins. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2293617&form=6&db=m Angiotensin II effects on the cytosolic free Ca2+ concentration in N1E-115 neuroblastoma cells: kinetic properties of the Ca2+ transient measured in single fura-2-loaded cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2295618&form=6&db=m Activation of phospholipase C via adenosine receptors provides synergistic signals for secretion in antigen-stimulated RBL-2H3 cells. Evidence for a novel adenosine receptor. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2299488&form=6&db=m History of whooping cough in nonvaccinated Swedish children, related to serum antibodies to pertussis toxin and filamentous hemagglutinin. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2300411&form=6&db=m Long term serologic follow-up after pertussis immunization. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2302562&form=6&db=m Activation of a K+ conductance by bradykinin and by inositol-1,4,5-trisphosphate in rat glioma cells: involvement of intracellular and extracellular Ca2+. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2303480&form=6&db=m The activation of human platelets mediated by anti-human platelet p24/CD9 monoclonal antibodies. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2303824&form=6&db=m Carbachol and bradykinin increase the production of diacylglycerol from sources other than inositol-containing phospholipids in PC12 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2304375&form=6&db=m Intrathecal pertussis toxin attenuates the morphine withdrawal syndrome in normal but not in arthritic rats. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2304450&form=6&db=m Demonstration of both A1 and A2 adenosine receptors in DDT1 MF-2 smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2304902&form=6&db=m Protective immunogenicity of two synthetic peptides selected from the amino acid sequence of Bordetella pertussis toxin subunit S1. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2304959&form=6&db=m Pertussis toxin inhibits morphine-induced release of adenosine from the spinal cord. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2310780&form=6&db=m A sex difference in the effect of prostaglandins on hormone-stimulated glycogenolysis in primary cultures of rat hepatocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2313126&form=6&db=m Widespread silent transmission of pertussis in families: antibody correlates of infection and symptomatology. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2315351&form=6&db=m Pertussis toxin inhibits morphine analgesia and prevents opiate dependence. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2319400&form=6&db=m Immunogenicity and safety of a pertussis vaccine composed of pertussis toxin inactivated by hydrogen peroxide, in 18- to 23-month-old children. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2321787&form=6&db=m Synergistic interaction of morphine and halothane in the guinea pig ileum: effects of pertussis toxin. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2322266&form=6&db=m Effect of angiotensin II and III on inositol polyphosphate production in differentiated NG108-15 hybrid cells. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2322268&form=6&db=m A specific beta gamma-subunit of transducin stimulates ADP-ribosylation of the alpha-subunit by pertussis toxin. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2323384&form=6&db=m The effect of vasoactive intestinal polypeptide (VIP) on forskolin stimulated adenylate cyclase in the caudate-putamen of the rat. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2323818&form=6&db=m Characterization of genetically inactivated pertussis toxin mutants: candidates for a new vaccine against whooping cough. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2324200&form=6&db=m Signal transduction for chemotaxis and haptotaxis by matrix molecules in tumor cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2324547&form=6&db=m Serologic diagnosis of pertussis: evaluation of pertussis toxin and other antigens in enzyme-linked immunosorbent assay. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2325882&form=6&db=m Effects of pertussis toxin on the affinity of exocytosis for Ca2+ in bovine adrenal chromaffin cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2327295&form=6&db=m Modulation of interleukin 1 production by endotoxin, pertussis toxin, and indomethacin. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2334717&form=6&db=m A model for the interaction of muscarinic receptors, agonists, and two distinct effector substances. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2334853&form=6&db=m Pertussis toxin prevents induction of hippocampal long-term potentiation in the stratum radiatum and stratum oriens inputs to CA1 neurons. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2338946&form=6&db=m Serotonin receptor-mediated activation of adenylate cyclase in the neuroblastoma NCB.20: a novel 5-hydroxytryptamine receptor. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2341166&form=6&db=m Roles of the disulfide bond and the carboxy-terminal region of the S1 subunit in the assembly and biosynthesis of pertussis toxin. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2344043&form=6&db=m Isolation of pertussis toxin subunit proteins by reverse-phase high-performance liquid chromatography and reconstitution of the holotoxin molecule. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2345482&form=6&db=m Adenosine activation of a nuclear pool of protein kinase C in rat splenocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2351723&form=6&db=m Simple, efficient purification of filamentous hemagglutinin and pertussis toxin from Bordetella pertussis by hydrophobic and affinity interaction. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2352187&form=6&db=m On the presynaptic action of baclofen at inhibitory synapses between cultured rat hippocampal neurones. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2352276&form=6&db=m Preliminary X-ray crystallographic analysis of holotoxin from Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2353117&form=6&db=m Effect of prostaglandins on glycogenesis and glycogenolysis in primary cultures of rat hepatocytes--a role of prostaglandin D2 in the liver. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2357660&form=6&db=m Effects of Pasteurella haemolytica A1 culture supernatant on mechanisms controlling bovine alveolar macrophage oxygen radical production. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2358888&form=6&db=m Neuropeptide Y reduces calcium current and inhibits acetylcholine release in nodose neurons via a pertussis toxin-sensitive mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2363304&form=6&db=m Protection of mice inoculated with purified pertussis toxin and filamentous haemagglutinin against intracerebral challenge with live Bordetella pertussis. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2363691&form=6&db=m Photolabelling of mutant forms of the S1 subunit of pertussis toxin with NAD+. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2364431&form=6&db=m Recognition of a bacterial adhesion by an integrin: macrophage CR3 (alpha M beta 2, CD11b/CD18) binds filamentous hemagglutinin of Bordetella pertussis. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2368631&form=6&db=m 1 alpha,25-dihydroxyvitamin D3-induced increments in hepatocyte cytosolic calcium and lysophosphatidylinositol: inhibition by pertussis toxin and 1 beta,25-dihydroxyvitamin D3. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,2,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2369527&form=6&db=m Chemotactic activity of pertussis toxin on murine lymphocytes. Its potential role on lymphocyte accumulation in the lung. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2370104&form=6&db=m A new assay for invasion of HeLa 229 cells by Bordetella pertussis: effects of inhibitors, phenotypic modulation, and genetic alterations. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2374126&form=6&db=m The effects of cholera toxin, pertussis toxin, sodium fluoride and alpha-interferon on prostaglandin production by the guinea-pig endometrium. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2375859&form=6&db=m Quantitation of pertussis toxin in an enzyme linked immunosorbent assay with improved specificity. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2380376&form=6&db=m Immunoglobulin A antibodies to pertussis toxin and filamentous hemagglutinin in saliva from patients with pertussis. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2382222&form=6&db=m Inhibition of parietal cell H+ secretion by transforming growth factor alpha: a possible autocrine regulatory mechanism. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2384008&form=6&db=m The mouse as a model of experimental autoimmune uveoretinitis (EAU). therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2391378&form=6&db=m Transforming growth factor beta enhances parathyroid hormone stimulation of adenylate cyclase in clonal osteoblast-like cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2393405&form=6&db=m Hemoglobin causes release of inositol trisphosphate from vascular smooth muscle. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2395118&form=6&db=m Positive inotropic effect of carbachol and inositol phosphate levels in mammalian atria after pretreatment with pertussis toxin. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2395236&form=6&db=m Acetylcholine elicits metabolically mediated M2-muscarinic hyperpolarization in isolated rabbit sympathetic neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2397017&form=6&db=m Experimental autoimmune uveoretinitis in mice. Induction by a single eliciting event and dependence on quantitative parameters of immunization. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2401570&form=6&db=m Adenylate cyclase toxin is critical for colonization and pertussis toxin is critical for lethal infection by Bordetella pertussis in infant mice. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2402188&form=6&db=m Difference in effects of sodium fluoride and cholecystokinin on diacylglycerol accumulation and calcium increase in guinea pig gastric chief cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2402246&form=6&db=m Recognition of pertussis toxin by antibodies to synthetic peptides. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2405012&form=6&db=m Use of a Chinese hamster ovary cell cytotoxicity assay for the rapid diagnosis of pertussis. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2410236&form=6&db=m Stimulation of cyclic adenosine 3',5'-monophosphate production enhances hypothalamic luteinizing hormone-releasing hormone release without increasing prostaglandin E2 synthesis: studies in prepubertal female rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2411613&form=6&db=m Studies on the mechanism of desensitization of the cyclic AMP response to TSH stimulation in a cloned rat thyroid cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2414029&form=6&db=m Pertussis toxin treatment blocks hyperpolarization by muscarinic agonists in chick atrium. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2414570&form=6&db=m Coupling mechanisms of alpha 2-adrenoceptors. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2415001&form=6&db=m Effects of pertussis toxin treatment on metabolism in hamster brown adipocytes. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2419744&form=6&db=m H1-histamine receptors on human astrocytoma cells. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2419757&form=6&db=m GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2420644&form=6&db=m Changes in the guanine nucleotide-binding proteins, Gi and Go, during differentiation of 3T3-L1 cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2420967&form=6&db=m Adenosine and muscarinic cholinergic receptors attenuate cyclic AMP accumulation by different mechanisms in 1321N1 astrocytoma cells. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2423345&form=6&db=m Pertussis toxin (IAP) enhances maitotoxin (a putative Ca2+ channel agonist)-induced Ca2+ entry into synaptosomes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2423401&form=6&db=m Dual mechanisms involved in the development of diverse biological activities of islet-activating protein, (pertussis toxin) as revealed by chemical modification of the toxin molecule. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2423402&form=6&db=m A semi-synthetic glycoconjugate antigen prepared by chemical glycosilation of pertussis toxin by a meningococcal group C oligosaccharide hapten. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2423523&form=6&db=m Conformations of the alpha 39, alpha 41, and beta.gamma components of brain guanine nucleotide-binding proteins. Analysis by limited proteolysis. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2424786&form=6&db=m GTP gamma S-induced solubilization of actin and myosin from rabbit peritoneal neutrophil membrane. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2426098&form=6&db=m Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2427080&form=6&db=m Control of PTH secretion is mediated through calcium channels and is blocked by pertussis toxin treatment of parathyroid cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2428006&form=6&db=m On the mechanism of muscarinic inhibition of the cardiac Ca current. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2428258&form=6&db=m Acetylcholine activation of K+ channels in cell-free membrane of atrial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2429251&form=6&db=m On the mechanism of activation of muscarinic K+ channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2429669&form=6&db=m Effects of phorbol esters and pertussis toxin on agonist-stimulated cyclic AMP production in rat osteosarcoma cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2430096&form=6&db=m Gamma aminobutyric acid B receptor-mediated inhibition of adenylate cyclase in cultured cerebellar granule cells: blockade by islet-activating protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2430334&form=6&db=m A G protein couples serotonin and GABAB receptors to the same channels in hippocampus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2431389&form=6&db=m Role of intracellular Mg2+ in the activation of muscarinic K+ channel in cardiac atrial cell membrane. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2431411&form=6&db=m A guanine nucleotide-binding protein mediates the inhibition of voltage-dependent calcium current by somatostatin in a pituitary cell line. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2433273&form=6&db=m Phorbol 12-myristate 13-acetate and vasopressin potentiate the effect of corticotropin-releasing factor on cyclic AMP production in rat anterior pituitary cells. Mechanisms of action. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2433285&form=6&db=m Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A431 cells. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2433510&form=6&db=m Vascular smooth muscle: availability of calcium through alpha-adrenoceptor stimulation. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2434027&form=6&db=m Alpha 1-adrenergic regulation of TSH-stimulated cyclic AMP accumulation in rat thyroid cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2434528&form=6&db=m A1 and A2 adenosine receptors in rabbit cortical collecting tubule cells. Modulation of hormone-stimulated cAMP. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2434680&form=6&db=m Intracellular control of calcium and potassium currents in cardiac cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2434833&form=6&db=m Stimulation of T cells through the CD3/T-cell receptor complex: role of cytoplasmic calcium, protein kinase C translocation, and phosphorylation of pp60c-src in the activation pathway. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2435359&form=6&db=m Involvement of a GTP-binding protein in mediation of serotonin and acetylcholine responses in Xenopus oocytes injected with rat brain messenger RNA. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2435660&form=6&db=m Effect of monoclonal antibody to pertussis toxin on toxin activity. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2436669&form=6&db=m Pertussis toxin stimulates cholecystokinin-induced cyclic AMP formation but is without effect on secretagogue-induced calcium mobilization in exocrine pancreas. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2437034&form=6&db=m Maintenance of biological activity of pertussis toxin radioiodinated while bound to fetuin-agarose. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2437765&form=6&db=m An enzyme-linked-immunosorbent assay method for detection of immunoglobulins to pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2438053&form=6&db=m Modulation of carrier-induced epitopic suppression by Bordetella pertussis components and muramyl peptide. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2438270&form=6&db=m Promoter of the pertussis toxin operon and production of pertussis toxin. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2438330&form=6&db=m Effects of ADP-ribosylation of GTP-binding protein by pertussis toxin on immunoglobulin E-dependent and -independent histamine release from mast cells and basophils. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2438348&form=6&db=m The effect of pertussis toxin on mediator release from human basophils. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2438411&form=6&db=m Accumulation of a precursor of subunit S1 of pertussis toxin in cell envelopes of Bordetella pertussis in response to the membrane perturbant phenethyl alcohol. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2438697&form=6&db=m Activation of a muscarinic receptor selectively inhibits a rapidly inactivated Ca2+ current in rat sympathetic neurons. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2440204&form=6&db=m [Synthesis of monoclonal antibodies to tissue-specific antigens of human skin and thymus epithelium in polyclonal activation by pertussis toxin] causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2440314&form=6&db=m Pertussis toxin inhibits somatostatin-induced K+ conductance in human pituitary tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2440724&form=6&db=m The human genome encodes at least three non-allellic G proteins with alpha i-type subunits. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2440752&form=6&db=m Enhanced cAMP accumulation after termination of cholinergic action in the heart. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2440876&form=6&db=m Topographic analysis of antigenic determinants recognized by monoclonal antibodies to the photoreceptor guanyl nucleotide-binding protein, transducin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2442157&form=6&db=m Insulin-like growth factor II stimulates calcium influx in competent BALB/c 3T3 cells primed with epidermal growth factor. Characteristics of calcium influx and involvement of GTP-binding protein. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2442367&form=6&db=m Neurotensin and acetylcholine evoke common responses in frog oocytes injected with rat brain messenger ribonucleic acid. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2443492&form=6&db=m P2-purinergic receptors are coupled to two signal transduction systems leading to inhibition of cAMP generation and to production of inositol trisphosphate in rat hepatocytes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2443499&form=6&db=m Dopamine inhibits cytosolic Ca2+ increases in rat lactotroph cells. Evidence of a dual mechanism of action. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2443865&form=6&db=m Common alpha 2- and opiate effector mechanisms in the locus coeruleus: intracellular studies in brain slices. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2445960&form=6&db=m Calcium channel currents and their inhibition by (-)-baclofen in rat sensory neurones: modulation by guanine nucleotides. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2446508&form=6&db=m Somatostatin and muscarinic inhibition of canine enteric endocrine cells: cellular mechanisms. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2446725&form=6&db=m Multiple effects of phorbol ester on secretory activity in rabbit gastric glands and parietal cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2446873&form=6&db=m Protein kinase C potentiates isoproterenol-mediated cyclic AMP production without modifying the homologous desensitization process in J774 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2446919&form=6&db=m Human T lymphocyte mitogenesis in response to the B oligomer of pertussis toxin is associated with an early elevation in cytosolic calcium concentrations. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2446939&form=6&db=m Epinephrine impairs insulin release by a mechanism distal to calcium mobilization. Similarity to lipoxygenase inhibitors. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2447162&form=6&db=m Cholera toxin and pertussis toxin regulate the Fc receptor-mediated phagocytic response of human neutrophils in a manner analogous to regulation by monoclonal antibody 1C2. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2447504&form=6&db=m Activation of a G protein promotes agonist responses to calcium channel ligands. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2447745&form=6&db=m The interaction between pertussis toxin and 10 monoclonal antibodies. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2447922&form=6&db=m Monoclonal antibodies against pertussis toxin. Biochemical characterization and biological activity. diagnostic usage,ongoing research,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2448328&form=6&db=m Adenylate cyclase in human cytotrophoblasts: characterization and its role in modulating human chorionic gonadotropin secretion. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2449373&form=6&db=m Alpha 2-adrenergic receptors in brown adipose tissue of infant rats--II. Studies on function and regulation. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2449459&form=6&db=m Relationship between phospholipase C activation and prostaglandin E2 and cyclic adenosine monophosphate production in rabbit tubular epithelial cells. Effects of angiotensin, bradykinin, and arginine vasopressin. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2449624&form=6&db=m The protein kinase C activator 1-oleoyl-2-acetylglycerol inhibits voltage-dependent Ca2+ current in the pituitary cell line AtT-20. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2450153&form=6&db=m Use of synthetic peptides to map antigenic sites of Bordetella pertussis toxin subunit S1. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2450538&form=6&db=m Pertussis toxin pretreatment abolishes dihydropyridine inhibition of calcium flux in the 235-1 pituitary cell line. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2450566&form=6&db=m G-protein mediates voltage regulation of agonist binding to muscarinic receptors: effects on receptor-Na+ channel interaction. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2451241&form=6&db=m Antibodies to an alpha subunit of skeletal muscle calcium channels regulate parathyroid cell secretion. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2451825&form=6&db=m Effect of cholera toxin on histamine release from bone marrow-derived mouse mast cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2452165&form=6&db=m Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2452534&form=6&db=m [Development of a method for the quantitative determination of Bordetella pertussis toxin and the prospects of its use for diagnosis] diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2452990&form=6&db=m Pertussis toxin treatment does not inhibit the effects of the potassium channel opener BRL 34915 on rat isolated vascular and cardiac tissues. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2453065&form=6&db=m Guanine nucleotide-binding protein Go-induced coupling of neuropeptide Y receptors to Ca2+ channels in sensory neurons. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2453066&form=6&db=m Pertussis toxin-insensitive G protein mediates substance P-induced inhibition of potassium channels in brain neurons. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2453511&form=6&db=m Muscarinic stimulation of calcium influx and norepinephrine release in PC12 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2453577&form=6&db=m Human granulocyte-macrophage colony-stimulating factor and other cytokines prime human neutrophils for enhanced arachidonic acid release and leukotriene B4 synthesis. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2454105&form=6&db=m Myelin basic protein binds GTP at a single site in the N-terminus. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2454226&form=6&db=m Use of glycosyltransferases to restore pertussis toxin receptor activity to asialoagalactofetuin. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2454296&form=6&db=m Chronic exposure to pertussis toxin alters muscarinic receptor-mediated regulation of cyclic AMP metabolism in neuroblastoma x glioma NG108-15 hybrid cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2454806&form=6&db=m Dopamine inhibits prolactin secretion stimulated by the calcium channel agonist Bay-K-8644 through a pertussis toxin-sensitive G protein in anterior pituitary cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2455296&form=6&db=m Identification of a region in the S1 subunit of pertussis toxin that is required for enzymatic activity and that contributes to the formation of a neutralizing antigenic determinant. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2455808&form=6&db=m Modulation of the beta-adrenergic receptor-coupled adenylate cyclase by chemical inducers of differentiation: effects on beta receptors and the inhibitory regulatory protein Gi. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2455859&form=6&db=m Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2455877&form=6&db=m The agonist effect of Bay K 8644 on neuronal calcium channel currents is promoted by G-protein activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2456203&form=6&db=m Somatostatin blocks Ca2+ action potential activity in prolactin-secreting pituitary tumor cells through coordinate actions on K+ and Ca2+ conductances. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2456209&form=6&db=m Angiotensin II-induced stimulation of voltage-dependent Ca2+ currents in an adrenal cortical cell line. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2456451&form=6&db=m Reconstitution of somatostatin and muscarinic receptor mediated stimulation of K+ channels by isolated GK protein in clonal rat anterior pituitary cell membranes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2456492&form=6&db=m Reduction of the same calcium current component by A and C kinases: differential pertussis toxin sensitivity. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2456569&form=6&db=m Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2457032&form=6&db=m Atrial natriuretic factor reduces cyclic adenosine monophosphate content of human fibroblasts by enhancing phosphodiesterase activity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2457366&form=6&db=m Muscarinic receptor-mediated increase in cAMP levels in SK-N-SH human neuroblastoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2457531&form=6&db=m Control of voltage-dependent Ca2+ channels by G protein-coupled receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2458169&form=6&db=m Opioids excite rather than inhibit sensory neurons after chronic opioid exposure of spinal cord-ganglion cultures. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2458448&form=6&db=m Pharmacological characterization of muscarinic receptors mediating inhibition of adenylate cyclase activity in the rat retina. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2458770&form=6&db=m Effect of pertussis toxin on the inhibition of secretory activity by prostaglandin E2, somatostatin, epidermal growth factor and 12-O-tetradecanoylphorbol 13-acetate in parietal cells from rat stomach. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2458919&form=6&db=m Cyclic AMP-independent, dual regulation of voltage-dependent Ca2+ currents by LHRH and somatostatin in a pituitary cell line. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2459138&form=6&db=m Coupling between inositol phosphate formation and DNA synthesis in smooth muscle cells stimulated with neurokinin A. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2459200&form=6&db=m Activation of human neutrophils by substance P. Effect on oxidative metabolism, exocytosis, cytosolic Ca2+ concentration and inositol phosphate formation. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2459376&form=6&db=m On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2459776&form=6&db=m Pertussis toxin S1 mutant with reduced enzyme activity and a conserved protective epitope. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2459975&form=6&db=m Mechanism of adenosine receptor-induced renal vasoconstriction in rats. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2460348&form=6&db=m Mechanism of galanin-inhibited insulin release. Occurrence of a pertussis-toxin-sensitive inhibition of adenylate cyclase. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2460460&form=6&db=m Modulation of adenylate cyclase in human keratinocytes by protein kinase C. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2460578&form=6&db=m MHC-restricted recognition of immunogenic T cell epitopes of pertussis toxin reveals determinants in man distinct from the ADP-ribosylase active site. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2461094&form=6&db=m G protein in stimulation of PI hydrolysis by CCK in isolated rat pancreatic acinar cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2461098&form=6&db=m Mechanism of Li inhibition of vasopressin-sensitive adenylate cyclase in cultured renal epithelial cells. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2461198&form=6&db=m Direct coupling of a G-protein to dihydropyridine binding sites. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2461309&form=6&db=m Regulatory factors that determine growth and phenotype of normal human melanocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2461321&form=6&db=m Different tachykinin receptor subtypes are coupled to the phosphoinositide or cyclic AMP signal transduction pathways in rat submandibular cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2461557&form=6&db=m Beta gamma subunits of GTP-binding proteins inhibit muscarinic receptor stimulation of phospholipase C. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2462488&form=6&db=m Divalent cations suppress 3',5'-adenosine monophosphate accumulation by stimulating a pertussis toxin-sensitive guanine nucleotide-binding protein in cultured bovine parathyroid cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2463254&form=6&db=m Suppression of insulin release by galanin and somatostatin is mediated by a G-protein. An effect involving repolarization and reduction in cytoplasmic free Ca2+ concentration. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2463405&form=6&db=m [Functional guanine nucleotide-binding proteins in receptor-mediated modulation of voltage-dependent ion channels] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2463969&form=6&db=m Mapping of linear B-cell epitopes of the S2 subunit of pertussis toxin. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2464587&form=6&db=m Corticotropin-releasing factor receptors and actions in rat Leydig cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2464653&form=6&db=m Expression of pertussis toxin correlates with pathogenesis in Bordetella species. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2464756&form=6&db=m Bone Gla protein messenger ribonucleic acid is regulated by both 1,25-dihydroxyvitamin D3 and 3',5'-cyclic adenosine monophosphate in rat osteosarcoma cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2465274&form=6&db=m Epitopes on the S1 subunit of pertussis toxin recognized by monoclonal antibodies. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2465394&form=6&db=m G proteins couple alpha-adrenergic and GABAb receptors to inhibition of peptide secretion from peripheral sensory neurons. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2465405&form=6&db=m K+ channel and adenylate cyclase involvement in regulation of Ca2+-evoked release of [3H]dopamine from synaptosomes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2466693&form=6&db=m Pertussis toxin activates protein kinase C and a tyrosine protein kinase in the human T cell line Jurkat. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2466764&form=6&db=m Monoclonal antibodies to pertussis toxin: utilization as probes of toxin function. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2468472&form=6&db=m G-proteins modulate prolactin- and interleukin-2-stimulated mitogenesis in rat Nb2 lymphoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2468476&form=6&db=m Characterization of galanin receptors in the insulin-secreting cell line Rin m 5F: evidence for coupling with a pertussis toxin-sensitive guanosine triphosphate regulatory protein. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2468668&form=6&db=m Galanin can inhibit insulin release by a mechanism other than membrane hyperpolarization or inhibition of adenylate cyclase. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2468761&form=6&db=m Effect of pertussis toxin treatment on postjunctional alpha-1 and alpha-2 adrenoceptor function in the cardiovascular system of the pithed rat. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2469602&form=6&db=m Galanin inhibits insulin secretion by direct interference with exocytosis. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2469642&form=6&db=m Interactive effects of pertussis toxin and the phorbol ester tumour promotor, phorbol dibutyrate, on T-lymphocyte mitogenesis and the expression of phenotypic determinants. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2469646&form=6&db=m Pharmacological control of human basophil histamine release stimulated by eosinophil granule major basic protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2469760&form=6&db=m Human T cell clones define S1 subunit as the most immunogenic moiety of pertussis toxin and determine its epitope map. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2469878&form=6&db=m The specific GTP requirement for inositol 1,4,5-trisphosphate-induced Ca2+ release from skinned vascular smooth muscle. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2470085&form=6&db=m Muscarinic cholinergic induced secretin subsensitivity in rat isolated pancreatic acini. Effects on amylase release, cyclic adenosine monophosphate and inositol phosphate formation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2470088&form=6&db=m Identification of amino acid residues essential for the enzymatic activities of pertussis toxin. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2470471&form=6&db=m Galanin inhibits dopamine secretion and activates a potassium channel in pheochromocytoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2470586&form=6&db=m Galanin activates nucleotide-dependent K+ channels in insulin-secreting cells via a pertussis toxin-sensitive G-protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2471189&form=6&db=m Granulocyte-macrophage colony-stimulating factor and human neutrophils: role of guanine nucleotide regulatory proteins. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2471737&form=6&db=m Effect of nonhydrolyzable guanosine phosphate on IgE-mediated activation of phospholipase C and histamine release from rodent mast cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2472075&form=6&db=m Adenosine-sensitive phosphoinositide turnover in a newly established renal cell line. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2472357&form=6&db=m Glucocorticoids and dopamine-1 receptors on vascular smooth muscle cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2472428&form=6&db=m Guanine nucleotide-binding protein, alpha i-3, directly activates a cation channel in rat renal inner medullary collecting duct cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2473137&form=6&db=m Differential expression of Ia by murine keratinocytes and gut epithelium in response to recombinant gamma-interferon. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2473189&form=6&db=m Activation of rat peritoneal mast cells by substance P and mastoparan. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2474500&form=6&db=m Monoclonal antibodies that define neutralizing epitopes of pertussis toxin: conformational dependence and epitope mapping. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2474532&form=6&db=m Coupling of exogenous receptors to phospholipase C in Xenopus oocytes through pertussis toxin-sensitive and -insensitive pathways. Cross-talk through heterotrimeric G-proteins. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2475031&form=6&db=m Differential action of somatostatin on peptide-induced release of acetylcholine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2475109&form=6&db=m Tyrosine phosphorylation in human neutrophil. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2475434&form=6&db=m Cyclic adenosine 3',5'-monophosphate metabolism in activated T-cell clones. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2475609&form=6&db=m Muscarinic control of the hyperpolarization-activated current (if) in rabbit sino-atrial node myocytes. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2476550&form=6&db=m Somatostatin induces an inward rectification in rat locus coeruleus neurones through a pertussis toxin-sensitive mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2476562&form=6&db=m Leukotriene-D4 induced cell shrinkage in Ehrlich ascites tumor cells. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2477043&form=6&db=m Single-step purification of pertussis toxin and its subunits by heat-treated fetuin-sepharose affinity chromatography. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2477150&form=6&db=m G-protein involvement in matrix-mediated motility and invasion of high and low experimental metastatic B16 melanoma clones. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2477233&form=6&db=m Inactivation of pertussis toxin-sensitive guanyl nucleotide-binding proteins increase parathyroid hormone receptors and reverse agonist-induced receptor down-regulation in ROS 17/2.8 cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2477498&form=6&db=m Comparison of the effects of ions and GTP on substance P binding to membrane-bound and solubilized specific sites. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2478471&form=6&db=m Binding of pertussis toxin to eucaryotic cells and glycoproteins. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2478479&form=6&db=m Inhibition of pertussis toxin binding to model receptors by antipeptide antibodies directed at an antigenic domain of the S2 subunit. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2478524&form=6&db=m Environmental regulation of expression of virulence determinants in Bordetella pertussis. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2479640&form=6&db=m Opposing effects of fibroblast growth factor and pertussis toxin on alkaline phosphatase, osteopontin, osteocalcin, and type I collagen mRNA levels in ROS 17/2.8 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2479648&form=6&db=m Galanin receptor in the rat pancreatic beta cell line Rin m 5F. Molecular characterization by chemical cross-linking. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2480108&form=6&db=m Regulation of GH3 pituitary tumour-cell adenylate cyclase activity by activators of protein kinase C. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2480389&form=6&db=m Multiple T and B cell epitopes in the S1 subunit ("A"-monomer) of the pertussis toxin molecule. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2480920&form=6&db=m Neuropeptide Y-induced intracellular Ca2+ increases in vascular smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2481961&form=6&db=m Detoxification of pertussis toxin by site-directed mutagenesis. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2482023&form=6&db=m G-protein mRNA levels during adipocyte differentiation. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2482450&form=6&db=m Inhibition of noradrenaline release by neuropeptide Y in mouse atria does not involve inhibition of adenylate cyclase or a pertussis toxin-susceptible G protein. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2482818&form=6&db=m Pertussis toxin-sensitive G protein mediation of PGE2 inhibition of cAMP metabolism and phasic glucose-induced insulin secretion in HIT cells. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2483870&form=6&db=m Engineering bacterial toxin for the development of new vaccine against pertussis. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2484436&form=6&db=m Inhibitory actions of somatostatin on cyclic AMP and aldosterone production in agonist-stimulated adrenal glomerulosa cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2491804&form=6&db=m Changes in intracellular free calcium in isolated myometrial cells: role of extracellular and intracellular calcium and possible involvement of guanine nucleotide-sensitive proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2492022&form=6&db=m Growth factors, signaling pathways, and the regulation of proliferation and differentiation in BC3H1 muscle cells. II. Two signaling pathways distinguished by pertussis toxin and a potential role for the ras oncogene. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2492037&form=6&db=m Desensitization to parathyroid hormone in renal cells from aged rats is associated with alterations in G-protein activity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2492160&form=6&db=m Relationship of GTP-binding proteins, phospholipase C, and PGE2 synthesis in rat glomerular mesangial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2492276&form=6&db=m Choline-linked phosphoglycerides. A source of phosphatidic acid and diglycerides in stimulated neutrophils. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2492452&form=6&db=m Functionally distinct G proteins selectively couple different receptors to PI hydrolysis in the same cell. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2492805&form=6&db=m Angiotensin II receptors negatively coupled to adenylate cyclase in rat myocardial sarcolemma. Involvement of inhibitory guanine nucleotide regulatory protein. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2492997&form=6&db=m Pertussis toxin treatment in vivo is associated with a decline in G-protein beta-subunits. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2493095&form=6&db=m Pharmacological characterization of rat retinal dopamine receptors. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2493246&form=6&db=m Mastoparan, a wasp venom, stimulates insulin release by pancreatic islets through pertussis toxin sensitive GTP-binding protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2493392&form=6&db=m Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein Gi. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2493515&form=6&db=m The in vitro invasive behavior of human myelomonocytic cell lines is modulated by HuIFN-gamma and pertussis toxin. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2493960&form=6&db=m Effect of pertussis toxin on A1-receptor-mediated inhibition of insulin secretion. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2493963&form=6&db=m G proteins in Aplysia: biochemical characterization and regional and subcellular distribution. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2494069&form=6&db=m A pertussis toxin-sensitive GTP-binding protein plays a role in the G0-G1 transition of rat hepatocytes following establishment in primary culture. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2494077&form=6&db=m ATP stimulates secretion in human neutrophils and HL60 cells via a pertussis toxin-sensitive guanine nucleotide-binding protein coupled to phospholipase C. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2494171&form=6&db=m Guanosine 5'-O-(3-thiotrisphosphate) potentiates both thrombin- and platelet-derived growth factor-induced inositol phosphate release in permeabilized vascular smooth muscle cells. Signaling mechanisms distinguished by sensitivity to pertussis toxin and phorbol esters. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2494307&form=6&db=m Apical localization of the alpha subunit of GTP-binding protein Go in choroidal and ciliated ependymocytes. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2494427&form=6&db=m Cerebral muscarinic acetylcholine receptors interact with three kinds of GTP-binding proteins in a reconstitution system of purified components. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2494654&form=6&db=m Molecular model of the G protein alpha subunit based on the crystal structure of the HRAS protein. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2496120&form=6&db=m Possible involvement of a GTP-binding protein in a late event during endogenous ganglioside-modulated cellular proliferation. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2496161&form=6&db=m Subcellular distribution and membrane association of human neutrophil substrates for ADP-ribosylation by pertussis toxin and cholera toxin. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2496691&form=6&db=m An endogenous inhibitor of the ADP-ribosylation of GTP-binding proteins by pertussis toxin is present in bovine brain. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2496748&form=6&db=m G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2497730&form=6&db=m Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein Gi, which is inactivated upon challenge of hepatocytes with glucagon. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2497737&form=6&db=m Purification and characterization of predominant G-protein from bovine lung membranes. Biochemical and immunochemical comparison with Gi1 and Go purified from brain. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2498668&form=6&db=m Pertussis toxin and N-ethylmaleimide inhibit histamine- but not calcium ionophore-induced endothelium-dependent relaxation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2498669&form=6&db=m Interaction of agonists and selective antagonists with gastric smooth muscle muscarinic receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2498808&form=6&db=m Identification of the pertussis and cholera toxin substrates in normal and N-ras transformed NIH3T3 fibroblasts and an assessment of their involvement in bombesin-stimulation of inositol phospholipid metabolism. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2499496&form=6&db=m Pertussis toxin inhibits 1-methyladenine-induced maturation in starfish oocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2499653&form=6&db=m Tumor necrosis factor/cachectin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G proteins. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2499681&form=6&db=m Signal-transducing GTP-binding proteins of mammalian heart and lungs. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2500437&form=6&db=m Dynamics of the diradylglycerol responses of stimulated phagocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2500931&form=6&db=m Purification and identification of two pertussis-toxin-sensitive GTP-binding proteins of bovine spleen. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2500997&form=6&db=m Involvement of a pertussis toxin-sensitive G-protein in the pharmacological properties of septo-hippocampal neurones. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2501654&form=6&db=m Selective parasympathectomy increases the quantity of inhibitory guanine nucleotide-binding proteins in canine cardiac ventricle. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2502457&form=6&db=m G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2502548&form=6&db=m Thrombin and phorbol esters cause the selective phosphorylation of a G protein other than Gi in human platelets. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2503363&form=6&db=m Heterologous desensitization of the liver adenylyl cyclase: analysis of the role of G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2503397&form=6&db=m Concanavalin A stimulation of O2 consumption in electropermeabilized neutrophils via a pertussis toxin-insensitive G protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2504151&form=6&db=m Guanine-nucleotide-binding proteins Gi and Gs in fat-cells from normal, hypothyroid and obese human subjects. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2504165&form=6&db=m Low density lipoprotein and apoprotein B induce increases in inositol trisphosphate and cytosolic free Ca2+ via pertussis toxin-sensitive GTP-binding protein in vascular smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2504508&form=6&db=m Natural course of the impairment of endothelium-dependent relaxations after balloon endothelium removal in porcine coronary arteries. Possible dysfunction of a pertussis toxin-sensitive G protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2504631&form=6&db=m An adhesion-associated agonist from the zona pellucida activates G protein-promoted elevations of internal Ca2+ and pH that mediate mammalian sperm acrosomal exocytosis. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2504712&form=6&db=m Co-purification of A1 adenosine receptors and guanine nucleotide-binding proteins from bovine brain. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2505200&form=6&db=m Pertussis toxin treatment counteracts the cardiovascular effects of neuropeptide Y and clonidine in the awake unrestrained rat. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2505676&form=6&db=m Pertussis toxin-sensitive GTP-binding proteins may regulate phospholipase A2 in response to thrombin in rabbit platelets. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2505750&form=6&db=m The adipocyte Go alpha-immunoreactive polypeptide is different from the alpha subunit of the brain Go protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2505866&form=6&db=m Development of the inhibitory guanine nucleotide-binding regulatory protein in the rat testis. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2505887&form=6&db=m Intrahippocampal injection of pertussis toxin blocks adenosine suppression of synaptic responses. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2505888&form=6&db=m Pertussis toxin lesioning of the nucleus caudate-putamen attenuates adenylate cyclase inhibition and alters neuronal electrophysiological activity. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2506067&form=6&db=m Mechanism of noradrenaline-induced heterologous desensitization of adenylate cyclase stimulation in rat heart muscle cells: increase in the level of inhibitory G-protein alpha-subunits. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2506760&form=6&db=m G proteins mediate suppression of Ca2+-activated K current by acetylcholine in smooth muscle cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2506767&form=6&db=m Autonomic regulation of delayed rectifier K+ current in mammalian heart involves G proteins. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2506857&form=6&db=m Pertussis toxin inhibits differentiation induced by retinoic acid in a human promyelocytic leukemia cell line HL-60. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2507084&form=6&db=m Activation of the human neutrophil 5-lipoxygenase by exogenous arachidonic acid: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2507090&form=6&db=m Presynaptic inhibition by neuropeptide Y and baclofen in hippocampus: insensitivity to pertussis toxin treatment. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2507140&form=6&db=m Regulation of transforming growth factor beta 1 action by multiple transducing pathways: evidence for both G protein-dependent and -independent signaling. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2507552&form=6&db=m Polymorphonuclear leukocyte adherence induces actin polymerization by a transduction pathway which differs from that used by chemoattractants. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2507742&form=6&db=m Chronic exposure of NG 108-15 cells to opiate agonists does not alter the amount of the guanine nucleotide-binding proteins Gi and Go. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2507904&form=6&db=m Studies on nucleotide and receptor regulation of Gi proteins: effects of pertussis toxin. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2508623&form=6&db=m Transforming growth factor beta 1 treatment of AKR-2B cells is coupled through a pertussis-toxin-sensitive G-protein(s). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2508632&form=6&db=m Cholera toxin treatment produces down-regulation of the alpha-subunit of the stimulatory guanine-nucleotide-binding protein (Gs). diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2508636&form=6&db=m Demonstration of GTP-binding proteins and ADP-ribosylated proteins in rat liver Golgi fraction. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2508639&form=6&db=m Novel GTP-binding proteins in plasma membranes of the fungus Metarhizium anisopliae. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2508751&form=6&db=m Exocytotic enzyme release from rabbit polymorphonuclear leukocytes after treatment with fluoride and calcium. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2508752&form=6&db=m Involvement of a specific guanine nucleotide binding protein in receptor immunoglobulin stimulated inositol phospholipid hydrolysis. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2509234&form=6&db=m Baclofen induces spontaneous, rhythmic sharp waves in the rat hippocampal slice. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2509235&form=6&db=m Trypanosoma cruzi: infection of cultured human endothelial cells alters inositol phosphate synthesis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2509245&form=6&db=m Purification of GTP-binding proteins from bovine brain membranes. Identification of heterogeneity of the alpha-subunit of Go proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2509464&form=6&db=m Immunological and molecular characterization of Go alpha-like proteins in the Drosophila central nervous system. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2509681&form=6&db=m Angiotensin II receptor-mediated stimulation of cytosolic-free calcium and inositol phosphates in chick myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2510721&form=6&db=m Actin assembly in electropermeabilized neutrophils: role of G-proteins. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2511034&form=6&db=m Coupling of adenosine receptors to a pertussis toxin-sensitive G protein in the human heart. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2511051&form=6&db=m Transduction of the chemotactic signal to the actin cytoskeleton of Dictyostelium discoideum. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2511200&form=6&db=m Lipopolysaccharide response is linked to the GTP binding protein, Gi2, in the promonocytic cell line U937. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2511766&form=6&db=m Role of G proteins in the acetylcholine-induced potassium current of canine atrial cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2511846&form=6&db=m Insulin affects the ability of Gi to be ADP-ribosylated but does not elicit its phosphorylation in intact hepatocytes. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2511991&form=6&db=m Cholera and pertussis toxins amplify prostacyclin synthesis in aortic smooth muscle cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2512294&form=6&db=m Chemotactic peptide receptor-supported ADP-ribosylation of a pertussis toxin substrate GTP-binding protein by cholera toxin in neutrophil-type HL-60 cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2512299&form=6&db=m Association of ligand-receptor complexes with actin filaments in human neutrophils: a possible regulatory role for a G-protein. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2512386&form=6&db=m Distribution of the alpha-subunit of the guanine nucleotide-binding protein Gi2 and its comparison to G alpha o. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2512911&form=6&db=m The receptors for ATP and fMetLeuPhe are independently coupled to phospholipases C and A2 via G-protein(s). Relationship between phospholipase C and A2 activation and exocytosis in HL60 cells and human neutrophils. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2513319&form=6&db=m Two distinct Gi-proteins mediate formyl peptide receptor signal transduction in human leukemia (HL-60) cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2513385&form=6&db=m Adenosine receptor-mediated relaxation in coronary artery: evidence for a guanyl nucleotide-binding regulatory protein involvement. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2514005&form=6&db=m Excitation of locus coeruleus neurons by vasoactive intestinal peptide: evidence for a G-protein-mediated inward current. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2514098&form=6&db=m Muscarinic acetylcholine receptor-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to guanine-nucleotide-binding proteins in cardiac membranes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2514517&form=6&db=m Glutaraldehyde in whole-cell Bordetella pertussis vaccine. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2515070&form=6&db=m Na+ regulation of formyl peptide receptor-mediated signal transduction in HL 60 cells. Evidence that the cation prevents activation of the G-protein by unoccupied receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2515851&form=6&db=m Endothelial inositol phosphate generation and prostacyclin production in response to G-protein activation by AlF4-. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2517341&form=6&db=m Central pertussis toxin abolishes the intestinal inhibition induced by intracerebroventricular morphine. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2518286&form=6&db=m Cholinergic-induced [3H] noradrenaline release in rat brain cortical slices is mediated via a pertussis toxin sensitive GTP binding protein and involves activation of protein kinase C. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2518287&form=6&db=m G-protein dependent potentiation of calcium release from sarcoplasmic reticulum of skeletal muscle. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2518356&form=6&db=m Immunochemical comparison of pertussis toxin substrates in brain and peripheral tissues. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2521885&form=6&db=m Pertussis toxin effects on T lymphocytes are mediated through CD3 and not by pertussis toxin catalyzed modification of a G protein. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2523074&form=6&db=m Pertussis toxin induces structural changes in G alpha proteins independently of ADP-ribosylation. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2523468&form=6&db=m Pertussis toxin attenuates 5-hydroxytryptamine1A receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in rat hippocampal membranes. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2523928&form=6&db=m IL-2 secretion is pertussis toxin sensitive in a T lymphocyte hybridoma. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2525309&form=6&db=m [A study of the ability of Bordetella pertussis toxin to induce the formation of B-suppressors] causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2525485&form=6&db=m Subtype-specific increase in G-protein alpha-subunit mRNA by interleukin 1 beta. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2526752&form=6&db=m CD3/T-cell receptor coupling to a pertussis and cholera toxin-insensitive G-protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2527149&form=6&db=m D-2 dopamine receptor activation reduces free [3H]arachidonate release induced by hypophysiotropic peptides in anterior pituitary cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2527150&form=6&db=m A two-step mechanism by which corticotropin-releasing hormone releases hypothalamic beta-endorphin: the role of vasopressin and G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2527254&form=6&db=m Receptor-mediated phagocytosis in human neutrophils is associated with increased formation of inositol phosphates and diacylglycerol. Elevation in cytosolic free calcium and formation of inositol phosphates can be dissociated from accumulation of diacylglycerol. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2530240&form=6&db=m Vasopressin rapidly stimulates protein kinase C in digitonin-permeabilized Swiss 3T3 cells: involvement of a pertussis toxin-insensitive guanine nucleotide binding protein. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2533106&form=6&db=m Pharmacological characterization of muscarinic responses in rat hippocampal pyramidal cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2534943&form=6&db=m Properties of membranous phospholipase C from WRK1 cell: sensitivity to guanylnucleotides and bacterial toxins. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2535802&form=6&db=m Regulation of cytosolic pH in bovine parathyroid cells: effect of fluoride. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2535815&form=6&db=m Inhibition of parathyroid hormone release by maitotoxin, a calcium channel activator. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2535838&form=6&db=m Chemoattractant-stimulated GTPase activity is decreased on membranes from polymorphonuclear leukocytes incubated in chemoattractant. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2535841&form=6&db=m Kappa opiate agonists inhibit Ca2+ influx in rat spinal cord-dorsal root ganglion cocultures. Involvement of a GTP-binding protein. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2535845&form=6&db=m Recombinant alpha i-3 subunit of G protein activates Gk-gated K+ channels. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2535846&form=6&db=m Role of cysteine 41 of the A subunit of pertussis toxin. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2535990&form=6&db=m Guanine nucleotide-dependent, pertussis toxin-insensitive regulation of phosphoinositide turnover by bradykinin in bovine pulmonary artery endothelial cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2536026&form=6&db=m Studies of signal transduction in the respiratory burst-associated stimulation of fMet-Leu-Phe-induced tubulin tyrosinolation and phorbol 12-myristate 13-acetate-induced posttranslational incorporation of tyrosine into multiple proteins in activated neutrophils and HL-60 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2536032&form=6&db=m Growth factors, signaling pathways, and the regulation of proliferation and differentiation in BC3H1 muscle cells. I. A pertussis toxin-sensitive pathway is involved. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2536043&form=6&db=m Bacterial toxins affect early events of T lymphocyte activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2536046&form=6&db=m Lipopolysaccharide priming of human neutrophils for an enhanced respiratory burst. Role of intracellular free calcium. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2536047&form=6&db=m Vasopressin V1 receptors on the principal cells of the rabbit cortical collecting tubule. Stimulation of cytosolic free calcium and inositol phosphate production via coupling to a pertussis toxin substrate. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2536079&form=6&db=m Opioid receptors of neuroblastoma cells are in two domains of the plasma membrane that differ in content of G proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2536429&form=6&db=m Mu and delta opioid receptors inhibit serotonin release in rat hippocampus. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2536574&form=6&db=m Mu-type opioid receptors in rat periaqueductal gray-enriched P2 membrane are coupled to guanine nucleotide binding proteins. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2536675&form=6&db=m Evolutionary trees for the genus Bordetella. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2536779&form=6&db=m Human serum antibody responses to Bordetella pertussis infection and pertussis vaccination. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2536937&form=6&db=m Early reversible induction of leukotriene synthesis in chicken myelomonocytic cells transformed by a temperature-sensitive mutant of avian leukemia virus E26. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537034&form=6&db=m Effects of lidocaine on sarcolemmal fluidity and cellular cAMP in rat cardiomyocytes. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537115&form=6&db=m Involvement of guanine nucleotide binding proteins in neutrophil activation and priming by GM-CSF. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537233&form=6&db=m Maitotoxin, a potent, general activator of phosphoinositide breakdown. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537290&form=6&db=m The kyotorphin (tyrosine-arginine) receptor and a selective reconstitution with purified Gi, measured with GTPase and phospholipase C assays. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537296&form=6&db=m Prostaglandin E receptors in bovine adrenal medulla are coupled to adenylate cyclase via Gi and to phosphoinositide metabolism in a pertussis toxin-insensitive manner. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537325&form=6&db=m Interleukin 3-stimulated proliferation is sensitive to pertussis toxin: evidence for a guanyl nucleotide regulatory protein-mediated signal transduction mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537359&form=6&db=m Studies on molecular regulation of phagocytosis in neutrophils. Con A-mediated ingestion and associated respiratory burst independent of phosphoinositide turnover, rise in [Ca2+]i, and arachidonic acid release. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537401&form=6&db=m Platelet-activating factor-induced phosphoinositide metabolism in differentiated U-937 cells in culture. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537406&form=6&db=m Pharmacological characterization of the M1 muscarinic receptors expressed in murine fibroblast B82 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537490&form=6&db=m Impaired formation of the second messenger cAMP in mononuclear blood cells of children with pertussis. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537732&form=6&db=m Correlation between ribosylation of pertussis toxin substrates and inhibition of peptidoglycan-, muramyl dipeptide- and lipopolysaccharide-induced mitogenic stimulation in B lymphocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537798&form=6&db=m Fluoride activation of neutrophils: similarities to formylmethionyl-leucyl-phenylalanine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537932&form=6&db=m Phase variation in Bordetella pertussis by frameshift mutation in a gene for a novel two-component system. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2538009&form=6&db=m Inhibition of FSH-stimulated cAMP accumulation by mono(2-ethylhexyl) phthalate in primary rat Sertoli cell cultures. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2538067&form=6&db=m Regulation of cAMP metabolism by PGE2 in cortical and medullary thick ascending limb of Henle's loop. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2538069&form=6&db=m Effects of low-sodium diet on regulation of platelet alpha 2-adrenergic receptors in young and elderly humans. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2538078&form=6&db=m Mechanism of neuropeptide Y inhibition of vasopressin action in rat cortical collecting tubule. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2538344&form=6&db=m Elevated levels of the guanine nucleotide binding protein, Go, are associated with differentiation of neuroblastoma x glioma hybrid cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2538569&form=6&db=m Opioid receptors in magnesium-digitonin-solubilized rat brain membranes are tightly coupled to a pertussis toxin-sensitive guanine nucleotide-binding protein. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2538696&form=6&db=m G regulatory proteins and muscarinic receptor signal transduction in mucous acini of rat submandibular gland. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2538814&form=6&db=m Epinephrine induces changes in the subcellular distribution of the inhibitory GTP-binding protein Gi alpha-2 and a 38-kDa phosphorylated protein in the human platelet. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2539466&form=6&db=m Coupling of hepatic prostaglandin receptors to adenylate cyclase through a pertussis toxin sensitive guanine nucleotide regulatory protein. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2539864&form=6&db=m Plasma membrane associated phospholipase C from human platelets: synergistic stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis by thrombin and guanosine 5'-O-(3-thiotriphosphate). therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2539969&form=6&db=m Effects of pertussis toxin on resorption of 19-day-old fetal rat long bones. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2540185&form=6&db=m Two different G-proteins mediate neuropeptide Y and bradykinin-stimulated phospholipid breakdown in cultured rat sensory neurons. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2540255&form=6&db=m 1,25-dihydroxyvitamin D3 induces responsiveness to the chemotactic peptide f-Met-Leu-Phe in the human monocytic line U937: dissociation between calcium and oxidative metabolic responses. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2540429&form=6&db=m Site of pertussis toxin-induced ADP-ribosylation on Gi is critical for receptor modulation of GDP interaction with Gi. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2540969&form=6&db=m Purine and pyrimidine nucleotides potentiate activation of NADPH oxidase and degranulation by chemotactic peptides and induce aggregation of human neutrophils via G proteins. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2541005&form=6&db=m Regulation of glucose transport by insulin, bombesin, and bradykinin in Swiss 3T3 fibroblasts: involvement of protein kinase C-dependent and -independent mechanisms. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2541140&form=6&db=m Cyclic AMP can partially restore platelet-derived growth factor-stimulated prostaglandin E2 biosynthesis, and calcium mobilization in EJ-ras-transformed NIH-3T3 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2541143&form=6&db=m Characterization of the membrane-associated GTPase activity: effects of chemotactic factors and toxins. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2541292&form=6&db=m GABAB receptor activation inhibits Ca2+-activated potassium channels in synaptosomes: involvement of G-proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2541317&form=6&db=m Cyclic AMP levels in lung and spleen tissue of mice treated with pertussis toxin. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2541406&form=6&db=m GTP-binding proteins mediate acetylcholine inhibition of voltage dependent calcium channels in hippocampal neurons. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2541621&form=6&db=m Alterations of cytosolic calcium in LLC-PK1 cells induced by vasopressin and exogenous purines. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2541716&form=6&db=m Phorbol ester dissociates endothelin-stimulated phosphoinositide hydrolysis and arachidonic acid release in vascular smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2542007&form=6&db=m Antagonism of contractants and relaxants at the level of intracellular calcium and phosphoinositide turnover in the rat uterus. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2542023&form=6&db=m Regulation of the mannose 6-phosphate/IGF II receptor expression at the cell surface by mannose 6-phosphate, insulin like growth factors and epidermal growth factor. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2542083&form=6&db=m Stimulation of adenosine receptor enhances alpha 1-adrenergic receptor-mediated activation of phospholipase C and Ca2+ mobilization in a pertussis toxin-sensitive manner in FRTL-5 thyroid cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2542311&form=6&db=m Amiloride interacts with guanine nucleotide regulatory proteins and attenuates the hormonal inhibition of adenylate cyclase. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2542409&form=6&db=m Signal transduction pathway for IL-1. Involvement of a pertussis toxin-sensitive GTP-binding protein in the activation of adenylate cyclase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2542416&form=6&db=m GTP-dependent hydrolysis of phosphatidylinositol-4,5-bisphosphate by soluble phospholipase C from adult human epidermis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2542460&form=6&db=m Ontogenesis of alpha 2-adrenoceptor coupling with GTP-binding proteins in the rat telencephalon. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2542467&form=6&db=m Effect of calcitonin gene-related peptide on skeletal muscle via specific binding site and G protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2542506&form=6&db=m Outbreak of pertussis in a residential facility for handicapped people. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2542937&form=6&db=m Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2543072&form=6&db=m A pertussis toxin-sensitive G protein in hippocampal long-term potentiation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2543359&form=6&db=m Effects of Bordetella pertussis toxin on catecholamine inhibition of insulin release from intact and electrically permeabilized rat islets. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2543367&form=6&db=m The effect of cholera toxin on the inhibition of vasopressin-stimulated inositol phospholipid hydrolysis is a cyclic AMP-mediated event at the level of receptor binding. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2543370&form=6&db=m Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2543676&form=6&db=m Muscarinic-stimulated norepinephrine release and phosphoinositide hydrolysis in PC12 cells are independent events. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2544167&form=6&db=m Interactions between adenylate cyclase inhibitors and beta-adrenoceptors in isolated human fat cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2544169&form=6&db=m Ca2+ influx stimulated by vasopressin is mediated by phosphoinositide hydrolysis in rat smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2544451&form=6&db=m Neuropeptide Y inhibits vasoactive intestinal peptide- and dopamine-induced cyclic AMP formation in human Ewing's sarcoma WE-68 cells. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2544567&form=6&db=m Pertussis toxin promoter sequences involved in modulation. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2544631&form=6&db=m Angiotensin II stimulates early proximal bicarbonate absorption in the rat by decreasing cyclic adenosine monophosphate. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2544781&form=6&db=m Identification of a DNA fragment in the genome of Bordetella pertussis carrying repeated DNA sequences also present in other Bordetella species. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2544850&form=6&db=m Adverse reactions and serologic response to a booster dose of acellular pertussis vaccine in children immunized with acellular or whole-cell vaccine as infants. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2545060&form=6&db=m [Immunobiologic activity of Bordetella pertussis strains defective in various virulence factors] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2545204&form=6&db=m Sodium and potassium regulation of guanine nucleotide-stimulated adenylate cyclase in brain. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2545297&form=6&db=m Elevation of intracellular cyclic AMP concentration fails to inhibit adrenaline-induced hyperpolarization in amphibian sympathetic neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2545456&form=6&db=m Thromboxane A2 activates phospholipase C in astrocytoma cells via pertussis toxin-insensitive G-protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2545488&form=6&db=m Pertussis toxin enhances follicle-stimulating hormone-stimulated cAMP production in rat seminiferous tubules in a stage-dependent manner. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2545639&form=6&db=m Antilipolytic effects of insulin and adenylate cyclase inhibitors on isolated human fat cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2545733&form=6&db=m Coupling of bradykinin receptors to phospholipase C in cultured fibroblasts is mediated by a G-protein. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2545786&form=6&db=m Mechanism of arachidonic acid liberation in platelet-activating factor-stimulated human polymorphonuclear neutrophils. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2545809&form=6&db=m Effect of granulocyte-macrophage colony-stimulating factor on superoxide production in cytoplasts and intact human neutrophils: role of protein kinase and G-proteins. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2545824&form=6&db=m Alpha 2-adrenergic and muscarinic cholinergic receptors have opposing actions on cyclic AMP levels in SK-N-SH human neuroblastoma cells. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2546744&form=6&db=m Nitroimidazole derivatives inhibit anterior pituitary cell function apparently by a direct effect on the catalytic subunit of the adenylate cyclase holoenzyme. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2546893&form=6&db=m Permeabilization and calcium-dependent activation of rabbit polymorphonuclear leukocytes by poly-L-arginine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2546919&form=6&db=m Expression and secretion of the S-1 subunit and C180 peptide of pertussis toxin in Escherichia coli. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2546944&form=6&db=m A permissive role of pertussis toxin substrate G-protein in P2-purinergic stimulation of phosphoinositide turnover and arachidonate release in FRTL-5 thyroid cells. Cooperative mechanism of signal transduction systems. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2547383&form=6&db=m Calcium mobilization, prostaglandin E2 and alpha 2-adrenoceptor modulation of glucose utilization and insulin secretion in pancreatic islets. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2547474&form=6&db=m Arachidonic acid-induced mobilization of calcium in human neutrophils: evidence for a multicomponent mechanism of action. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2547582&form=6&db=m Insulin-like growth factor-I potentiates thyrotropin stimulation of adenylyl cyclase in FRTL-5 cells. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2547657&form=6&db=m Mu type opioid receptors in rat periaqueductal gray-enriched P2 membrane are coupled to G-protein-mediated inhibition of adenylyl cyclase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2547667&form=6&db=m [Analysis of the nature of responses of neurons of rat spinal ganglia evoked by the activation of GABA-B receptors] ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2547718&form=6&db=m Invasion of HeLa 229 cells by virulent Bordetella pertussis. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2547780&form=6&db=m Possible direct linkage of insulin-like growth factor-II receptor with guanine nucleotide-binding proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2547784&form=6&db=m Granulocyte-macrophage colony-stimulating factor primes neutrophils by activating a pertussis toxin-sensitive G protein not associated with phosphatidylinositol turnover. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2547835&form=6&db=m Endothelin-induced increases in vascular smooth muscle Ca2+ do not depend on dihydropyridine-sensitive Ca2+ channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2547897&form=6&db=m Evidence for the presence of serotonin receptors negatively coupled to adenylate cyclase in the rabbit iris-ciliary body. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2547900&form=6&db=m Islet-activating protein inhibits the beta-adrenergic receptor facilitation elicited by gamma-aminobutyric acidB receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2547903&form=6&db=m Muscarinic and quisqualate receptor-induced phosphoinositide hydrolysis in primary cultures of striatal and hippocampal neurons. Evidence for differential mechanisms of activation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2548212&form=6&db=m Selective changes in mu opioid receptor properties induced by chronic morphine exposure. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2548304&form=6&db=m Possible mechanism of chrysotile asbestos-stimulated superoxide anion production in guinea pig alveolar macrophages. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2548386&form=6&db=m Leukotriene D4-induced proliferation of glomerular epithelial cells: PKC- and Na+-H+ exchanger-mediated response. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2548477&form=6&db=m Evidence that activation of a common G-protein by receptors for leukotriene B4 and N-formylmethionyl-leucyl-phenylalanine in HL-60 cells occurs by different mechanisms. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2548484&form=6&db=m Influence of bacterial toxins and forskolin upon vasopressin-induced inositol phosphate accumulation in WRK 1 cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2548512&form=6&db=m 36Cl- flux measurements on GABAA receptor-activated chloride exchange. Multiple mechanisms of the chloride channel inactivation. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2548638&form=6&db=m A comparison of bradykinin, angiotensin II and muscarinic stimulation of cultured bovine adrenal chromaffin cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2548663&form=6&db=m Dual opioid modulation of the action potential duration of mouse dorsal root ganglion neurons in culture. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2548952&form=6&db=m Activation of macrophages to express cytocidal activity correlates with inhibition of their responsiveness to macrophage colony-stimulating factor (CSF-1): involvement of a pertussis toxin-sensitive reaction. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2549039&form=6&db=m Effector coupling mechanisms of the cloned 5-HT1A receptor. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2549071&form=6&db=m Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2549145&form=6&db=m The location of filamentous hemagglutinin and pertussis toxin antigens of Bordetella pertussis by immunoelectron microscopy. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2549199&form=6&db=m Capsaicin-induced ion fluxes increase cyclic GMP but not cyclic AMP levels in rat sensory neurones in culture. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2549429&form=6&db=m Effects of pertussis toxin on opioid regulation of catecholamine release from rat and guinea pig brain slices. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2550109&form=6&db=m Different GTP-binding proteins mediate regulation of calcium channels by acetylcholine and noradrenaline in rat sympathetic neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2550263&form=6&db=m In vivo pertussis toxin treatment attenuates some, but not all, adenosine A1 effects in slices of the rat hippocampus. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2550370&form=6&db=m Modulation of leukotriene generation by pertussis toxin. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2550487&form=6&db=m Coupling of antagonistic signalling pathways in modulation of neutrophil function. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2550617&form=6&db=m Alpha-1 adrenergic stimulation of 1,4,5-inositol trisphosphate formation in ventricular myocytes. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2550854&form=6&db=m Phosphoinositides and GTP binding proteins involved in muscarinic generation of hippocampal rhythmic slow activity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2551026&form=6&db=m [Intracellular messengers in the regulation of renin secretion] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2551269&form=6&db=m ADP and, indirectly, ATP are potent inhibitors of cAMP production in intact isoproterenol-stimulated C6 glioma cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2551271&form=6&db=m Pancreastatin: a novel peptide inhibitor of parietal cell signal transduction. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2551276&form=6&db=m Angiogenin depresses aortic smooth muscle cell cAMP by a pertussis toxin sensitive mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2551506&form=6&db=m Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2551629&form=6&db=m Direct modulation by androgens of the response of human bone cells (SaOS-2) to human parathyroid hormone (PTH) and PTH-related protein. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2551649&form=6&db=m Facilitative actions of the protein kinase-C effector system on hormonally stimulated adenosine 3',5'-monophosphate production by swine luteal cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2551662&form=6&db=m Melatonin signal transduction in hamster brain: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2551700&form=6&db=m Action of calcitonin gene-related peptide on rat aortic smooth muscle. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2551727&form=6&db=m Inhibition by islet-activating protein, pertussis toxin, of retinoic acid-induced differentiation of human leukemic (HL-60) cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2551899&form=6&db=m Role of tryptophan 26 in the NAD glycohydrolase reaction of the S-1 subunit of pertussis toxin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2552017&form=6&db=m Presynaptic kappa-opioid receptors on noradrenergic nerve terminals couple to G proteins and interact with the alpha 2-adrenoceptors. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2552614&form=6&db=m Specific inhibition of FSH-stimulated cAMP accumulation by delta 9-tetrahydrocannabinol in cultures of rat Sertoli cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2552711&form=6&db=m [Isolation of hemolytic cultures of Bordetella pertussis intended for the production of acellular pertussis preparations and the characterization of their biological properties] therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2552724&form=6&db=m Effects of protein kinase C activation on cyclic AMP and testosterone production of rat Leydig cells in vitro. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2552760&form=6&db=m Modulation of IL-1-induced collagenase production in articular chondrocytes by pertussis toxin. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2552882&form=6&db=m GTP gamma S increases thrombin-mediated inositol trisphosphate accumulation in permeabilized human endothelial cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2552999&form=6&db=m Stimulation of intracellular topoisomerase I activity by vasopressin and thrombin. Differential regulation by pertussis toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2553166&form=6&db=m Priming of human neutrophils with N-formyl-methionyl-leucyl-phenylalanine by a calcium-independent, pertussis toxin-insensitive pathway. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2553201&form=6&db=m Modulation of the voltage-dependent sodium channel by agents affecting G-proteins: a study in Xenopus oocytes injected with brain RNA. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2553506&form=6&db=m [Role of a guanine nucleotide regulatory protein in exocrine pancreatic secretion--effects of cholera toxin and pertussis toxin on cholecystokinin action] ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2553586&form=6&db=m Effect of sodium fluoride on the generation of lipoxygenase products from human polymorphonuclear granulocytes, mononuclear cells and platelets--indication for the involvement of G proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2553677&form=6&db=m The bvgA gene of Bordetella pertussis encodes a transcriptional activator required for coordinate regulation of several virulence genes. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2553678&form=6&db=m Analysis of Bordetella pertussis virulence gene regulation by use of transcriptional fusions in Escherichia coli. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2553705&form=6&db=m Multiple signaling pathways of histamine H2 receptors. Identification of an H2 receptor-dependent Ca2+ mobilization pathway in human HL-60 promyelocytic leukemia cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2554097&form=6&db=m Muscarinic-agonist and guanine nucleotide stimulation of myo-inositol trisphosphate formation in membranes isolated from bovine iris sphincter smooth muscle: effects of short-term cholinergic desensitization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2554109&form=6&db=m Multiple affinity binding states of the sigma receptor: effect of GTP-binding protein-modifying agents. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2554154&form=6&db=m The negative inotropic effect of neuropeptide Y on the ventricular cardiomyocyte. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2554227&form=6&db=m Pertussis (whooping cough) toxin and Bordetella pertussis whole-cell antibody levels in a healthy New Zealand population. diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2554254&form=6&db=m A unique sequence of the Bordetella pertussis toxin operon. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2554311&form=6&db=m Pertussis holotoxoid formed in vitro with a genetically deactivated S1 subunit. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2554689&form=6&db=m Modulation of responsiveness of the adenylate cyclase system in avian chondroprogenitor cells by pertussis toxin, PTH, and PGE2. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2554695&form=6&db=m Signal transduction via the B cell antigen receptor: involvement of a G protein and regulation of signaling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2554898&form=6&db=m Pineal muscarinic phosphoinositide response: pertussis toxin resistant signaling with very low receptor number. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2555081&form=6&db=m Developmental changes in guanine nucleotide regulatory proteins in the rat myocardial alpha 1-adrenergic receptor complex. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2555207&form=6&db=m Reconstitution of the solubilized mu-opioid receptor coupled to a GTP-binding protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2555613&form=6&db=m [Prostaglandin E2 receptor and GTP binding protein in the normal and nephrotic rat kidney] ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2555764&form=6&db=m Inhibition of lipolysis by agents acting via adenylate cyclase in fat cells from infants and adults. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2555977&form=6&db=m Effect of pertussis toxin and the cGMP lowering agent LY83583 on the relaxation induced by nitrates in isolated bovine mesenteric artery. A comparison between glyceryl trinitrate, isosorbide dinitrate and isosorbide 5-mononitrate. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2556039&form=6&db=m Bradykinin activates protein kinase C in cultured cortical collecting tubular cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2556130&form=6&db=m Neutrophil activation by surface bound IgG is via a pertussis toxin insensitive G protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2556274&form=6&db=m Neomycin induces high-affinity agonist binding of G-protein-coupled receptors. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2556387&form=6&db=m G protein subunit, alpha i-3, activates a pertussis toxin-sensitive Na+ channel from the epithelial cell line, A6. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2556393&form=6&db=m Increase in Gs and cyclic AMP generation in HIT cells. Evidence that the 45-kDa alpha-subunit of Gs has greater functional activity than the 52-kDa alpha-subunit. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2556434&form=6&db=m Preparation of filamentous hemagglutinin from Bordetella pertussis and assay for serum antibodies to filamentous hemagglutinin and pertussis toxin for clinical and public health laboratories. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2556491&form=6&db=m Influence of pertussis toxin on parathyroid hormone stimulated cyclic AMP production and phosphate transport in opossum kidney cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557011&form=6&db=m Stimulation of generation of inositol phosphates by carbamoylcholine and its inhibition by phorbol esters and iodide in dog thyroid cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557017&form=6&db=m Cholera toxin ADP-ribosylates the receptor-coupled form of pertussis toxin-sensitive G-proteins. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557246&form=6&db=m Histamine and bradykinin stimulate the phosphoinositide turnover in human umbilical vein endothelial cells via different G-proteins. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557332&form=6&db=m The type I insulin-like growth factor receptor is a motility receptor in human melanoma cells. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557345&form=6&db=m Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557347&form=6&db=m The human 5-HT1A receptor expressed in HeLa cells stimulates sodium-dependent phosphate uptake via protein kinase C. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557410&form=6&db=m Dissociation between muscarinic receptor-mediated inhibition of adenylate cyclase and autoreceptor inhibition of [3H] acetylcholine release in rat hippocampus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557437&form=6&db=m Interaction between calcium channel ligands and guanine nucleotides in cultured rat sensory and sympathetic neurones. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557510&form=6&db=m Calcitonin inhibits accumulation of cyclic AMP in stimulated peritoneal macrophages from normal rats but not from osteopetrotic (incisors-absent) littermates. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557556&form=6&db=m Involvement of the mu-opiate receptor in peripheral analgesia. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557657&form=6&db=m Platelet-activating factor (PAF) stimulates phosphatidylinositol hydrolysis in human peripheral blood mononuclear leukocytes. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557836&form=6&db=m Role of guanine nucleotide regulatory proteins in insulin stimulation of glucose transport in rat adipocytes. Influence of bacterial toxins. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2558571&form=6&db=m Catecholamine modulation of calcium currents in clonal pancreatic beta-cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2558574&form=6&db=m A1-adenosine receptor-mediated inhibition of adipocyte adenylate cyclase and lipolysis in Zucker rats. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2558898&form=6&db=m Pertussis toxin treatment counteracts intramembrane interactions between neuropeptide Y receptors and alpha 2-adrenoceptors. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2558910&form=6&db=m Opposing effects of acetylcholine on the two classes of voltage-dependent calcium channels in hippocampal neurons. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2559082&form=6&db=m The effect of cyclodextrin on lipopolysaccharide production in cultures of Bordetella pertussis. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2559720&form=6&db=m Neurotensin stimulates inositol trisphosphate-mediated calcium mobilization but not protein kinase C activation in HT29 cells. Involvement of a G-protein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2559733&form=6&db=m Functional alpha 2-adrenoceptors in rat adipocytes: inhibition of cyclic AMP accumulation. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2560167&form=6&db=m Direct modulation of voltage-dependent calcium channels by muscarinic activation of a pertussis toxin-sensitive G-protein in hippocampal neurons. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2560178&form=6&db=m Pertussis toxin inhibits neuropeptide Y-induced feeding in rats. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2560238&form=6&db=m Specific identification of Bordetella pertussis by the polymerase chain reaction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2560387&form=6&db=m Differential G protein-mediated coupling of neurotransmitter receptors to Ca2+ channels in rat dorsal root ganglion neurons in vitro. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2560391&form=6&db=m Antibodies to the GTP binding protein, Go, antagonize noradrenaline-induced calcium current inhibition in NG108-15 hybrid cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2561302&form=6&db=m Inhibition by pertussis toxin of guanyl nucleotides exchange on transducin in bovine rod cell membranes. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2561591&form=6&db=m Phorbol ester-induced inhibition of the beta-adrenergic system in pulmonary endothelium: role of a pertussis toxin-sensitive protein. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2561914&form=6&db=m Fibroblast growth factor potentiates receptor- and nonreceptor-mediated stimulation of adenylate cyclase in hamster fibroblasts. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2561940&form=6&db=m Multiple defects occur in the guanine nucleotide regulatory protein system in liver plasma membranes of obese (fa/fa) but not lean (Fa/Fa) Zucker rats: loss of functional Gi and abnormal Gs function. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2562061&form=6&db=m Involvement of postsynaptic alpha 2-adrenoceptors and guanine nucleotide-binding protein in guanabenz-induced cardiovascular suppressant effects in the rat. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2562405&form=6&db=m [Coupling of GTP-binding protein to inositol phospholipid metabolism in chemoattractant-stimulated guinea pig peritoneal exudate macrophages] diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2563204&form=6&db=m Regulation of Na+-K+-ATPase activity in kidney proximal tubules: involvement of GTP binding proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2563240&form=6&db=m Direct inhibitory effects of a somatostatin analog, SMS 201-995, on AR4-2J cell proliferation via pertussis toxin-sensitive guanosine triphosphate-binding protein-independent mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2563300&form=6&db=m Excitatory amino acids inhibit stimulated phosphoinositide hydrolysis in the rat prefrontal cortex. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2563638&form=6&db=m Pertussis toxin effects on transmitter release from perivascular nerve terminals. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2563646&form=6&db=m Prostaglandin E2 and alpha 2 adrenoceptor agonists inhibit the pentose phosphate shunt in pancreatic islets. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2563928&form=6&db=m Linkage between somatostatin and acid secretion: evidence from use of pertussis toxin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2564342&form=6&db=m Secretion-stimulating and secretion-inhibiting hormones stimulate high-affinity pertussis-toxin-sensitive GTPases in membranes of a pituitary cell line. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2564375&form=6&db=m Failure of pertussis toxin to inhibit activation of guanylate cyclase by the heat-stable enterotoxin of Escherichia coli (STa) in the T84 cell line. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2564396&form=6&db=m Alpha 2-adrenergic receptor stimulation mobilizes intracellular Ca2+ in human erythroleukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2565041&form=6&db=m Regulation of ATP-sensitive K+ channels in insulinoma cells: activation by somatostatin and protein kinase C and the role of cAMP. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2565411&form=6&db=m Adrenergic control of cAMP generation in rat inner medullary collecting tubule cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2565843&form=6&db=m Mechanism for increase of gastrin release by secretin in Zollinger-Ellison syndrome. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2566191&form=6&db=m Antisecretory effects of somatostatin and vasopressin in the rat colon descendens in vitro. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2566661&form=6&db=m Opiate and peptide inhibition of transmitter release in parasympathetic nerve terminals. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2567609&form=6&db=m Muscarinic receptor subclassification and G-proteins: significance for lithium action in affective disorders and for the treatment of the extrapyramidal side effects of neuroleptics. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2567705&form=6&db=m Atrial natriuretic factor effects on cyclic nucleotides in a human renal cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2568040&form=6&db=m [Use of an immunoblotting method for identifying the individual proteins in the antigenic complexes of Bordetella pertussis] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2568113&form=6&db=m Neurotensin, bradykinin and somatostatin inhibit cAMP production in neuroblastoma N1E115 cells via both pertussis toxin sensitive and insensitive mechanisms. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2568262&form=6&db=m Biochemical evidence for somatostatin receptors in murine neuroblastoma clone N1E-115. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2568356&form=6&db=m Cloning, sequence analysis, and permanent expression of a human alpha 2-adrenergic receptor in Chinese hamster ovary cells. Evidence for independent pathways of receptor coupling to adenylate cyclase attenuation and activation. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2568880&form=6&db=m Somatostatin inhibition of adenylate cyclase activity in different brain areas. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2568963&form=6&db=m Inhibition of acid secretion by bombesin is partly mediated by release of fundic somatostatin. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2569396&form=6&db=m Protein kinase C stimulates adenylate cyclase activity in prolactin-secreting rat adenoma (GH4C1) pituicytes by inactivating the inhibitory GTP-binding protein Gi. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2569447&form=6&db=m Use of the promoter fusion transposon Tn5 lac to identify mutations in Bordetella pertussis vir-regulated genes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2569506&form=6&db=m Regulation of cyclic AMP formation in cultures of human foetal astrocytes by beta 2-adrenergic and adenosine receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2569545&form=6&db=m Selective blockade of dopamine D-1 receptor by SCH 23390 affects dopamine agonist binding to 3H-spiperone labeled D-2 receptors in rat striatum. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2569832&form=6&db=m Somatostatin receptors on canine fundic D-cells: evidence for autocrine regulation of gastric somatostatin. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2570359&form=6&db=m The inhibition of alpha 1-adrenoceptor-mediated contractions of rabbit pulmonary artery by Ca2+-withdrawal, pertussis toxin and N-ethylmaleimide is dependent on agonist intrinsic efficacy. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2571073&form=6&db=m Functional characterization of a rat dopamine D-2 receptor cDNA expressed in a mammalian cell line. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2571500&form=6&db=m Association of two pertussis toxin-sensitive G-proteins with the D2-dopamine receptor from bovine striatum. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2571974&form=6&db=m Somatostatin activates an inwardly rectifying K+ channel in neonatal rat atrial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2572128&form=6&db=m Characterization of alpha 2-adrenoceptors in a plasma membrane enriched fraction from the insulin-secreting cell line RINm5F. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2572561&form=6&db=m Lethal infection by Bordetella pertussis mutants in the infant mouse model. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2572651&form=6&db=m Serum IgG, IgA, and IgM responses to pertussis toxin, filamentous hemagglutinin, and agglutinogens 2 and 3 after infection with Bordetella pertussis and immunization with whole-cell pertussis vaccine. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2574041&form=6&db=m Characterization of relaxin-stimulated cyclic AMP in cultured rat anterior pituitary cells: influence of dopamine, somatostatin and gender. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2574175&form=6&db=m Beta-adrenergic and somatostatin receptors regulate Na-H exchange independent of cAMP. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2574465&form=6&db=m Somatostatin-14 and somatostatin-28 induce opposite effects on potassium currents in rat neocortical neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2575164&form=6&db=m Intracellular calcium mobilization triggered by a glutamate receptor in rat cultured hippocampal cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2576279&form=6&db=m Inhibition of adenylate cyclase in bovine ciliary process and rabbit iris ciliary body to alpha 2-adrenergic agonists. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2577120&form=6&db=m Adenosine A1 receptors inhibit both adenylate cyclase activity and TRH-activated Ca2+ channels by a pertussis toxin-sensitive mechanism in GH3 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2578698&form=6&db=m Protective effects of human gamma-globulin preparations against experimental aerosol infections of mice with Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2579078&form=6&db=m Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. A possible involvement of the toxin-specific substrate in the Ca2+-mobilizing receptor-mediated biosignaling system. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2583243&form=6&db=m The H-L subgroup of guinea-pig cardiac M2 receptors (M2 beta) regulates inositol phosphate formation. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2585923&form=6&db=m Comparative studies on the binding specificities of pertussis toxin and different lectins to human erythrocytes. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2594196&form=6&db=m A dopaminergic inhibitory postsynaptic potential mediated by an increased potassium conductance. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2609017&form=6&db=m Effects of adenosine and pertussis toxin on lipolysis in adipocytes from exercise-trained male rats. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2612159&form=6&db=m Effects of acidic and basic fibroblast growth factors on osteoblastic cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2613276&form=6&db=m Inhibition of lymphocyte circulation in mice by pertussis toxin. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2613295&form=6&db=m Dual effects of pertussis toxin on murine neutrophils in vivo. I. Pertussis toxin inhibits extravasation potential of mature neutrophils while simultaneously stimulating granulopoiesis. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2614735&form=6&db=m 2-Chloroadenosine reduces the N calcium current of cultured mouse sensory neurones in a pertussis toxin-sensitive manner. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2622329&form=6&db=m Bordetella adenylate cyclase is a virulence associated factor and an immunoprotective antigen. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2627497&form=6&db=m Optimal conditions for the toxoiding of pertussis toxin with 1-ethyl-3(3-dimethylaminopropyl) carbodiimide.HCl. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2629905&form=6&db=m Human cellular immune responses to Bordetella pertussis infection. causal interaction,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2633154&form=6&db=m Dihydropiridine inhibition of K+ and maitotoxin stimulated calcium fluxes in PC12 cells: effect of pertussis toxin. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2643630&form=6&db=m Interleukin 1 and tumor necrosis factor stimulate human vascular endothelial cells to promote transendothelial neutrophil passage. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2646638&form=6&db=m Angiogenin stimulates endothelial cell prostacyclin secretion by activation of phospholipase A2. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2651522&form=6&db=m Effect of tumor necrosis factor and granulocyte/macrophage colony-stimulating factor on neutrophil degranulation. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2653848&form=6&db=m Pancreastatin inhibits insulin release from Rin m 5F cells: reversion by pertussis toxin. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2654538&form=6&db=m Genetics of pertussis toxin. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2655616&form=6&db=m [Regulation mechanisms of receptors mediated activation of phospholipase c and inositol-1,4,5-triphosphate sensitive Ca2+ release and Ca2+ uptake in exocrine glandular cells] ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2660922&form=6&db=m [Effect of bacterial toxins on the mitogen-induced increase of the Ca2+ concentration in the cytoplasm of rat thymocytes. The role of N proteins] ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2661247&form=6&db=m Evidence for a pertussis toxin-sensitive G protein involved in the control of meiotic reinitiation of Xenopus laevis oocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2669097&form=6&db=m Feasible improvements in vaccines in the Expanded Programme on Immunization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2670900&form=6&db=m Cloning, nucleotide sequence, and hybridization studies of the type IIb heat-labile enterotoxin gene of Escherichia coli. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2672946&form=6&db=m Formation and function of eicosanoids in the central nervous system. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2679912&form=6&db=m Effector function for RAS oncogene in interleukin-3-dependent myeloid cells involves diminished efficacy of prostaglandin E1-mediated inhibition of proliferation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2680112&form=6&db=m Growth regulation of multi-factor-dependent myeloid cell lines: IL-4, TGF-beta and pertussis toxin modulate IL-3- or GM-CSF-induced growth by controlling cell cycle length. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2683073&form=6&db=m Mutants of pertussis toxin suitable for vaccine development. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2686699&form=6&db=m Anti-invasive activities of experimental chemotherapeutic agents. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2689633&form=6&db=m On the transduction mechanism for muscarine-induced inhibition of M-current in cultured rat sympathetic neurones. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2694520&form=6&db=m Diverse functions of muscarinic acetylcholine receptor subtypes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2695283&form=6&db=m The effect of islet-activating protein (IAP) of pertussis toxin on the spontaneous diabetic syndrome in the rat. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2696845&form=6&db=m LH action in the Leydig cell: modulation by angiotensin II and corticotropin releasing hormone, and regulation of P450(17) alpha mRNA. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2699431&form=6&db=m Signal transduction in hamster fibroblasts overexpressing the human EGF receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2703495&form=6&db=m Alkylation of cysteine 41, but not cysteine 200, decreases the ADP-ribosyltransferase activity of the S1 subunit of pertussis toxin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2707169&form=6&db=m The glucocorticoid hormone dexamethasone reverses the growth hormone-releasing properties of the cholinomimetic carbachol. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2707851&form=6&db=m Expression of pertussis toxin in Bordetella bronchiseptica and Bordetella parapertussis carrying recombinant plasmids. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2708448&form=6&db=m Platelet-derived growth factor and angiotensin II cause increases in cytosolic free calcium by different mechanisms in vascular smooth muscle cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2715641&form=6&db=m Regulation of formyl peptide receptor binding to rabbit neutrophil plasma membranes. Use of monovalent cations, guanine nucleotides, and bacterial toxins to discriminate among different states of the receptor. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2717058&form=6&db=m Transduction mechanism involving the presynaptic adenosine receptor at mouse motor nerve terminals. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2720295&form=6&db=m Effect of phorbol ester and pertussis toxin on the enhancement of noradrenaline release by angiotensin II in mouse atria. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2720305&form=6&db=m Pertussis toxin prevents the inhibitory effect of adenosine and unmasks adenosine-induced excitation of mammalian motor nerve endings. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2721572&form=6&db=m Biphasic dose-response curve to muscarine on the rat superior cervical ganglion. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2721573&form=6&db=m Pertussis toxin sensitivity of drug-induced potentials on the rat superior cervical ganglion. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2721914&form=6&db=m Effects of pertussis toxin and indomethacin on murine lymphocytes in the bronchoalveolar lavage fluids. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2722137&form=6&db=m Abnormal dopamine sensitivity in some human prolactinomas. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2722238&form=6&db=m Immune response to dimeric subunits of the pertussis toxin B oligomer. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2722243&form=6&db=m Lectinlike properties of pertussis toxin. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2722782&form=6&db=m Three states for the formyl peptide receptor on intact cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2725694&form=6&db=m Pertussis toxin prevents adenosine receptor- and m-cholinoceptor-mediated sinus rate slowing and AV conduction block in the guinea-pig heart. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2725790&form=6&db=m [Metabolic and ionic dependence of neuronal responses evoked by serotonin in the rat sensory ganglia] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2732469&form=6&db=m Molecular mechanisms of lymphocyte extravasation. III. The loss of lymphocyte extravasation potential induced by pertussis toxin is not mediated via the activation of protein kinase C. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2732946&form=6&db=m Characterization of the adenosine receptor in cultured embryonic chick atrial myocytes: coupling to modulation of contractility and adenylate cyclase activity and identification by direct radioligand binding. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2737291&form=6&db=m Identification of an active-site residue in subunit S1 of pertussis toxin by photocrosslinking to NAD. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2740622&form=6&db=m Effect of platelet-activating factor (PAF) on cytosolic free calcium in human peripheral blood mononuclear leukocytes. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2746325&form=6&db=m Activators of protein kinase C selectively enhance inactivation of a calcium current component of cultured sensory neurons in a pertussis toxin-sensitive manner. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2752606&form=6&db=m Dual effects of pertussis toxin on in vitro invasive behavior of metastatic lymphoma variants. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2759713&form=6&db=m Immunoglobulin E response to pertussis toxin in whooping cough and after immunization with a whole-cell and an acellular pertussis vaccine. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2760463&form=6&db=m Mastoparan, a wasp venom peptide, identifies two discrete mechanisms for elevating cytosolic calcium and inositol trisphosphates in human polymorphonuclear leukocytes. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2764114&form=6&db=m Carbachol inhibits stimulant-induced increases in fundic D-cell cytosolic Ca2+ concentration. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2766098&form=6&db=m Acetylcholine inhibition in rabbit sinoatrial node is prevented by pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2766515&form=6&db=m Endothelium-dependent inhibition of ergonovine-induced contraction is impaired in porcine coronary arteries with regenerated endothelium. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2768336&form=6&db=m Guanine nucleotide-induced polymerization of actin in electropermeabilized human neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2768444&form=6&db=m Subclass compositions of immunoglobulin G to pertussis toxin in patients with whooping cough, in healthy individuals, and in recipients of a pertussis toxoid vaccine. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2777805&form=6&db=m Nature of thrombin-induced sustained increase in cytosolic calcium concentration in cultured endothelial cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2778738&form=6&db=m Pertussis toxin inhibits endothelium-dependent relaxations to certain agonists in porcine coronary arteries. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2781857&form=6&db=m Effect of hyperreactivity to endotoxin on the toxicity of pertussis vaccine and pertussis toxin in mice. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2784677&form=6&db=m A novel calcium signalling response in the breast cancer cell line MDA-468. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2785517&form=6&db=m In vitro induction of antigen specific antibody synthesis and proliferation of T lymphocytes with acellular pertussis vaccines, pertussis toxin and filamentous haemagglutinin in humans. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2786590&form=6&db=m Experimental autoimmune uveoretinitis (EAU) in rats: abrogation of resistance to the induction and augmentation of the inflammation by pertussis toxin. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2787652&form=6&db=m Interleukin-1 induces a pertussis toxin-sensitive increase in diacylglycerol accumulation in mouse thymoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2787778&form=6&db=m Effect of protein kinase C inhibitor (H-7) and calmodulin antagonist (W-7) on pertussis toxin-induced IL-1 production by human adherent monocytes. Comparison with lipopolysaccharide as a stimulator of IL-1 production. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2792007&form=6&db=m Estradiol-stimulated increases in uterine eosinophils and nuclear type II estrogen-binding sites are prevented by pertussis toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2792065&form=6&db=m The effects of baclofen and pertussis toxin on epileptiform activity induced in the hippocampal slice by magnesium depletion. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2792283&form=6&db=m Rhythmical bursting activity and GABAergic mechanisms in the medial septum of normal and pertussis toxin-pretreated rats. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2795430&form=6&db=m Noradrenaline release enhanced by cholera toxin and pertussis toxin in rat cerebral cortical slices. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2797958&form=6&db=m Sixteen-month follow-up of antibodies to pertussis toxin after primary immunization with acellular or whole cell vaccine. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2807535&form=6&db=m Photolabeling of Glu-129 of the S-1 subunit of pertussis toxin with NAD. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2807541&form=6&db=m Effects of mutations on enzyme activity and immunoreactivity of the S1 subunit of pertussis toxin. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2808670&form=6&db=m Development of a rapid diagnostic test for pertussis: direct detection of pertussis toxin in respiratory secretions. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2812285&form=6&db=m Inhibition by pertussis toxin of the soporific effects induced by stimulation of dopamine D2 autoreceptors in the ventral tegmental area in rats. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2815971&form=6&db=m Adverse reactions and antibody response to an acellular pertussis toxoid vaccine in adult volunteers. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2819742&form=6&db=m Neurochemical and behavioural evidence that dopamine D-2 receptors in striatum couple to the Ni regulatory protein and inhibition of cyclic AMP accumulation. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2820423&form=6&db=m Pharmacological and biochemical characterization of dopamine receptors mediating stimulation of a high affinity GTPase in rat striatum. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2820995&form=6&db=m Thrombin activation of the Na+/H+ exchanger in vascular smooth muscle cells. Evidence for a kinase C-independent pathway which is Ca2+-dependent and pertussis toxin-sensitive. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2821015&form=6&db=m Relationship between pH, sodium, and shape changes in chemotactic-factor-stimulated human neutrophils. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2822023&form=6&db=m Foetal-calf serum stimulates a pertussis-toxin-sensitive high-affinity GTPase activity in rat glioma C6 BU1 cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2822091&form=6&db=m Sulfhydryl-alkylating reagents inactivate the NAD glycohydrolase activity of pertussis toxin. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2822188&form=6&db=m Dual regulation of neutrophil adenylate cyclase by fluoride and its relationship to cellular activation. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2822500&form=6&db=m [Characterization of adrenal medullary opioid receptors. II. Coupling of adrenal medullary opioid receptors to GTP binding proteins] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2822640&form=6&db=m Cholinergic inhibition of cAMP accumulation in Sertoli cells cultured from immature hamsters. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2822641&form=6&db=m Tonic inhibition of adenylate cyclase in cultured hamster Sertoli cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2822721&form=6&db=m Mechanism of activation of lymphocyte Na+/H+ exchange by concanavalin A. A calcium- and protein kinase C-independent pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2823274&form=6&db=m Role of a guanine nucleotide-binding protein in alpha 1-adrenergic receptor-mediated Ca2+ mobilization in DDT1 MF-2 cells. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2823384&form=6&db=m An M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2823535&form=6&db=m Inhibitory action of pertussis toxin on parathyroid hormone and prostaglandin E2-stimulated bone resorption in cultured neonatal mouse calvaria. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2823811&form=6&db=m Bradykinin stimulation of inositol phosphate and calcium responses in insensitive to pertussis toxin in NG115-401L neuronal cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2823909&form=6&db=m Fluoride-mediated activation of guinea pig neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2824334&form=6&db=m Genes for two homologous G-protein alpha subunits map to different human chromosomes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2824463&form=6&db=m Stimulation and inhibition of cAMP accumulation by glucagon in canine hepatocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2824464&form=6&db=m Forskolin-resistant Y1 mutants harbor defects associated with the guanyl nucleotide-binding regulatory protein, Gs. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2824610&form=6&db=m Involvement of a guanine-nucleotide-binding component in membrane IgM-stimulated phosphoinositide breakdown. causal interaction,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2824646&form=6&db=m Pertussis toxin blocks the inhibitory effects of calcitonin on cyclic AMP accumulation in stimulated cultured human monocytes. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2826189&form=6&db=m Pertussis toxin blocks 5-HT1A and GABAB receptor-mediated inhibition of serotonergic neurons. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2826276&form=6&db=m Stimulation of inositol phosphate formation in FRTL-5 rat thyroid cells by catecholamines and its relationship to changes in 45Ca2+ efflux and cyclic AMP accumulation. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2826588&form=6&db=m Inhibition and activation of interleukin 2 synthesis by direct modification of guanosine triphosphate-binding proteins. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2826699&form=6&db=m Opiate-inhibited adenylate cyclase in rat brain membranes depleted of Gs-stimulated adenylate cyclase. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2826911&form=6&db=m Angiotensin II receptors and mechanisms of action in adrenal glomerulosa cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2827070&form=6&db=m Pertussis toxin blocks a late inhibitory postsynaptic potential in hippocampal CA3 neurons. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2827625&form=6&db=m Light-induced changes in the content of inositol phosphates in squid (Loligo pealei) retina. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2827638&form=6&db=m Evidence that muscarinic cholinergic receptors selectively interact with either the cyclic AMP or the inositol phosphate second-messenger response systems. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2827687&form=6&db=m Differential coupling of mu-competitive and mu-noncompetitive delta opiate receptors to guanine nucleotide binding proteins in rat brain membranes. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2827999&form=6&db=m Age-related and testicular regression-induced changes in adenosine 3',5'-monophosphate responses in cultured hamster Sertoli cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2828018&form=6&db=m Angiotensin II (A-II) steroidogenic refractoriness in Y-1 cells in the presence of A-II receptors negatively coupled to adenylate cyclase. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2828126&form=6&db=m [Coupling of guanine nucleotide inhibitory protein to somatostatin receptors on rat pancreatic acinar membranes] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2828913&form=6&db=m Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2828956&form=6&db=m Adrenal medullary opioid receptors are linked to GTP-binding proteins, pertussis toxin substrates. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2828958&form=6&db=m Varying expression of opioid receptors and GTP-binding proteins in human pheochromocytomas. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2829820&form=6&db=m Different effects of phorbol ester on angiotensin II- and stable GTP analogue-induced activation of polyphosphoinositide phosphodiesterase in membranes isolated from rat renal mesangial cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2829839&form=6&db=m Inhibition of the GTPase activity of transducin by an NAD+:arginine ADP-ribosyltransferase from turkey erythrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2829886&form=6&db=m Demonstration of the presence of G-proteins in hepatic microsomal fraction. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2829901&form=6&db=m Fluoride can activate the respiratory burst independently of Ca2+, stimulation of phosphoinositide turnover and protein kinase C translocation in primed human neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2830096&form=6&db=m The role of cyclic nucleotides in atrial natriuretic peptide-mediated inhibition of aldosterone secretion. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2830121&form=6&db=m Pertussis toxin abolishes the antinociception mediated by opioid receptors in rat spinal cord. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2830124&form=6&db=m Adrenergic stimulation of vascular prostacyclin: role of alpha 1-receptors in smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2830264&form=6&db=m The bombesin receptor is coupled to a guanine nucleotide-binding protein which is insensitive to pertussis and cholera toxins. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2830276&form=6&db=m Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2831023&form=6&db=m Dual effects of calcitonin and calcitonin gene-related peptide on intracellular cyclic 3',5'-monophosphate in a human breast cancer cell line. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2831082&form=6&db=m Block of light responses of salamander rods by pertussis toxin and reversal by nicotinamide. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2831352&form=6&db=m Cholera toxin and pertussis toxin stimulate prostaglandin E2 synthesis in a murine macrophage cell line. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2831476&form=6&db=m Beta-adrenoceptor, vasoactive intestinal polypeptide (VIP) and neuropeptide tyrosine (NPY) receptors functionally coupled to adenylate cyclase in the human neuroblastoma SK-N-MC cell line. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2831967&form=6&db=m Mono(ADP-ribosylation) in rat liver mitochondria. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2832160&form=6&db=m Pertussis toxin abolishes the inhibitory effects of prostaglandins E1, E2, I2 and F2 alpha on hormone-induced cAMP accumulation in cultured hepatocytes. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2832242&form=6&db=m Prostanoid inhibition of canine parietal cells: mediation by the inhibitory guanosine triphosphate-binding protein of adenylate cyclase. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2832415&form=6&db=m The formylpeptide chemoattractant receptor copurifies with a GTP-binding protein containing a distinct 40-kDa pertussis toxin substrate. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2833223&form=6&db=m Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2833227&form=6&db=m Platelet-activating factor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate stimulates the production of reactive oxygen intermediates in macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2833233&form=6&db=m Effects of pertussis toxin on growth factor-stimulated inositol phosphate formation and DNA synthesis in Swiss 3T3 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2833416&form=6&db=m Activation of adenylate cyclase in rat fat cells promotes an increase in GTP content which controls the enzyme activity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2833494&form=6&db=m Angiotensin II receptors and inhibitory actions in Leydig cells. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2833506&form=6&db=m Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2833686&form=6&db=m Multiple agonist-affinity states of opioid receptors: regulation of binding by guanyl nucleotides in guinea pig cortical, NG108-15, and 7315c cell membranes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2833889&form=6&db=m Different sensitivity to phorbol esters and pertussis toxin of bombesin- and platelet-derived growth factor-induced, phospholipase C-mediated hydrolysis of phosphoinositides in NIH/3T3 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2833927&form=6&db=m ADP-ribosylation of membrane proteins by bacterial toxins in the presence of NAD glycohydrolase. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2834069&form=6&db=m The effects of pertussis toxin and cholera toxin on mitogen-induced interleukin-2 production: evidence for G protein involvement in signal transduction. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2834200&form=6&db=m Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide-specific phospholipase C. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2834280&form=6&db=m [Abnormalities in the beta-adrenergic receptor-adenylate cyclase system in the ventricular myocardium of spontaneously hypertensive rats] ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2834352&form=6&db=m Properties of a novel GTP-binding protein which is associated with soluble phosphoinositides-specific phospholipase C. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2834364&form=6&db=m Regulation of cyclic AMP metabolism in rabbit cortical collecting tubule cells by prostaglandins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2834452&form=6&db=m G protein coupling of antigen receptor-stimulated polyphosphoinositide hydrolysis in B cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2835261&form=6&db=m Pertussis toxin inhibits cAMP surface receptor-stimulated binding of [35S]GTP gamma S to Dictyostelium discoideum membranes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2835651&form=6&db=m Effects of chronic morphine exposure on opioid inhibition of adenylyl cyclase in 7315c cell membranes: a useful model for the study of tolerance at mu opioid receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2835989&form=6&db=m Cytoplasmic pH change induced by leukotriene B4 in human neutrophils. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2836171&form=6&db=m Adenosine inhibition of the hormonal response in the Sertoli cell is reversed by pertussis toxin. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2836504&form=6&db=m Selective modulation by guanine nucleotides of the high affinity subset of plasma membrane receptors for leukotriene B4 on human polymorphonuclear leukocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2836511&form=6&db=m Mechanism involved in the mobilization of neutrophil calcium by 5-hydroxyeicosatetraenoate. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2836843&form=6&db=m Relaxation of bovine mesenteric artery induced by glyceryl trinitrate is attenuated by pertussis toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2837214&form=6&db=m Phorbol ester modulates serotonin-stimulated phosphoinositide breakdown in cultured vascular smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2837460&form=6&db=m GTP-dependent inhibition of insulin secretion by epinephrine in permeabilized RINm5F cells. Lack of correlation between insulin secretion and cyclic AMP levels. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2837532&form=6&db=m ADP-ribosylation with pertussis toxin modulates the GTP-sensitive opioid ligand binding in digitonin-soluble extracts of rat brain membranes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2838256&form=6&db=m A pertussis toxin-sensitive G-protein mediates the alpha 2-adrenergic receptor inhibition of melatonin release in photoreceptive chick pineal cell cultures. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2838273&form=6&db=m Variations in guanine-binding proteins (Gs, Gi) in cultured bovine adrenal cells. Consequences on the effects of phorbol ester and angiotensin II on adrenocorticotropin-induced and cholera-toxin-induced cAMP production. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2838362&form=6&db=m Evidence for involvement of guanine nucleotide-binding regulatory proteins in the activation of phospholipases by hormones. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2838520&form=6&db=m Clostridium difficile toxin A stimulates intracellular calcium release and chemotactic response in human granulocytes. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2838525&form=6&db=m Bradykinin-activated membrane-associated phospholipase C in Madin-Darby canine kidney cells. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2838563&form=6&db=m Increased intracellular cyclic adenosine monophosphate inhibits T lymphocyte-mediated cytolysis by two distinct mechanisms. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2838600&form=6&db=m Phorbol ester modulation of cyclic AMP accumulation in a primary culture of rat aortic smooth muscle cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2838617&form=6&db=m Second messengers associated with the action of AII and dopamine D2 receptors in anterior pituitary. Relationship with prolactin secretion. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2839035&form=6&db=m Changes in expression of a functional Gi protein in cultured rat heart cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2839333&form=6&db=m Involvement of Ni protein in the functional coupling of the atrial natriuretic factor (ANF) receptor to adenylate cyclase in rat lung plasma membranes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2839363&form=6&db=m Different sensitivities of the responses of human neutrophils stimulated with immune complex and C5a anaphylatoxin to pertussis toxin. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2839476&form=6&db=m Inhibition of inositol phosphate production is a late, Ca2+-dependent effect of D2 dopaminergic receptor activation in rat lactotroph cells. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2839480&form=6&db=m Effect of tumor necrosis factor on GTP binding and GTPase activity in HL-60 and L929 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2839494&form=6&db=m Sodium modulates opioid receptors through a membrane component different from G-proteins. Demonstration by target size analysis. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2839545&form=6&db=m Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2839620&form=6&db=m Characterization of bradykinin-induced phosphoinositide turnover in neurohybrid NCB-20 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2839761&form=6&db=m Oxymetazoline inhibits adenylate cyclase by activation of serotonin-1 receptors in the OK cell, an established renal epithelial cell line. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2839762&form=6&db=m Binding kinetics of delta opioid receptors differ for microsomal and synaptic sites. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2840260&form=6&db=m Inhibition by islet-activating protein, pertussis toxin, of P2-purinergic receptor-mediated iodide efflux and phosphoinositide turnover in FRTL-5 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2840261&form=6&db=m Mechanisms of glucagon-induced homologous and heterologous desensitization of adenylate cyclase in membranes and whole Sertoli cells of the rat. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2840318&form=6&db=m Mechanism of neutrophil activation by NAF, a novel monocyte-derived peptide agonist. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2840437&form=6&db=m Prostaglandin-sensitive adenylyl cyclase of cultured preadipocytes and mature adipocytes of the rat: probable role of Gi in determination of stimulatory or inhibitory action. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2840439&form=6&db=m Propionic acid-induced calcium mobilization in human neutrophils. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2840571&form=6&db=m Regulation of follicle-stimulating hormone binding to receptors on bovine calf testis membranes by cholera toxin-sensitive guanine nucleotide binding protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2840971&form=6&db=m Modulation of octopamine-mediated production of cyclic AMP by phorbol-ester-sensitive protein kinase C in an insect cell line. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2841152&form=6&db=m P2-purinoceptor-stimulated phosphoinositide turnover in chick myotubes. Calcium mobilization and the role of guanyl nucleotide-binding proteins. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2841161&form=6&db=m Agonist-stimulated high-affinity GTPase in Dictyostelium membranes. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2841544&form=6&db=m Does interleukin 2 stimulus-response coupling result in generation of intracellular second messengers? unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2842188&form=6&db=m Effects of phosphorylation of inhibitory GTP-binding protein by cyclic AMP-dependent protein kinase on its ADP-ribosylation by pertussis toxin, islet-activating protein. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2842665&form=6&db=m Serotonin-induced deoxyribonucleic acid synthesis in vascular smooth muscle cells involves a novel, pertussis toxin-sensitive pathway. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2842749&form=6&db=m Effects of ras-encoded proteins and platelet-derived growth factor on inositol phospholipid turnover in NRK cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2843502&form=6&db=m Tyrosine kinase-activating growth factors potentiate thrombin- and AIF4- -induced phosphoinositide breakdown in hamster fibroblasts. Evidence for positive cross-talk between the two mitogenic signaling pathways. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2843624&form=6&db=m Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2843625&form=6&db=m Effects of ethanol in vitro on the beta adrenergic receptor-coupled adenylate cyclase system. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2843748&form=6&db=m Mechanism of enhanced sensitivity to bradykinin in pertussis toxin-treated fibroblasts: toxin increases bradykinin-stimulated prostaglandin formation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2843781&form=6&db=m Pertussis toxin inhibits signal transduction at a specific metabolotropic glutamate receptor in primary cultures of cerebellar granule cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2843929&form=6&db=m Dopamine inhibition of NaKATPase activity in proximal convoluted tubule cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2844114&form=6&db=m Sympathetic neural and alpha-adrenergic modulation of arrhythmias. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2844508&form=6&db=m Characterization of the MMQ cell, a prolactin-secreting clonal cell line that is responsive to dopamine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2844509&form=6&db=m Autoregulation of acute progesterone and adenosine 3',5'-monophosphate responses to follicle-stimulating hormone (FSH) in porcine granulosa cells: effects of FSH, cholera toxin, forskolin, and pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2844550&form=6&db=m Phorbol ester regulates stimulatory and inhibitory pathways of the hormone-sensitive adenylate cyclase system in rat reticulocytes. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2844658&form=6&db=m Regulation of tumour necrosis factor production by mouse peritoneal macrophages: the role of cellular cyclic AMP. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2844756&form=6&db=m Colony-stimulating factor 1-induced Na+ influx into human monocytes involves activation of a pertussis toxin-sensitive GTP-binding protein. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2844762&form=6&db=m Characterization and possible mechanisms of alpha 2-adrenergic receptor-mediated sensitization of forskolin-stimulated cyclic AMP production in HT29 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2844857&form=6&db=m Inhibitory guanosine triphosphate-binding protein-mediated regulation of vasopressin action in isolated single medullary tubules of mouse kidney. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2845165&form=6&db=m Stimulation of phospholipase C-mediated hydrolysis of phosphoinositides by adenosine 5'-triphosphate via P2-purinoceptors in cultured rat aortic vascular smooth muscle cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2845423&form=6&db=m Role of two different guanine nucleotide-binding proteins in the antagonistic modulation of the S-type K+ channel by cAMP and arachidonic acid metabolites in Aplysia sensory neurons. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2845933&form=6&db=m Cholera-toxin and corticotropin modulation of inositol phosphate accumulation induced by vasopressin and angiotensin II in rat glomerulosa cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2845952&form=6&db=m Inhibition of formation of cyclic AMP and cyclic GMP by vasopressin in smooth-muscle cells is insensitive to pertussis toxin. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2846156&form=6&db=m Serotonin as a major serum factor inducing the phospholipase C-mediated hydrolysis of phosphoinositides in normal rat kidney cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2846274&form=6&db=m Cloned M1 muscarinic receptors mediate both adenylate cyclase inhibition and phosphoinositide turnover. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2846548&form=6&db=m Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2846571&form=6&db=m Mechanism of inhibition of transducin guanosine triphosphatase activity by vanadate. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2846705&form=6&db=m Induction of signal transduction in human neutrophils by Candida albicans hyphae: the role of pertussis toxin-sensitive guanosine triphosphate-binding proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2846825&form=6&db=m Insulin activation of cyclic AMP phosphodiesterase in intact ureteral segments. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2847013&form=6&db=m G protein-adrenergic interactions in the heart. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2847261&form=6&db=m Asbestos-induced activation of the respiratory burst in rabbit neutrophils. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2847750&form=6&db=m Alteration of mast cell responsiveness to adenosine by pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2848025&form=6&db=m Activation of inositol phospholipid breakdown in HL60 cells by P2-purinergic receptors for extracellular ATP. Evidence for mediation by both pertussis toxin-sensitive and pertussis toxin-insensitive mechanisms. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2848040&form=6&db=m Bombesin enhancement of cAMP accumulation in Swiss 3T3 cells: evidence of a dual mechanism of action. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2848043&form=6&db=m Actin depolymerization and inhibition of capping induced by pentoxifylline in human lymphocytes and neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2848425&form=6&db=m Halothane interaction with guanine nucleotide binding proteins in mouse heart. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2848512&form=6&db=m Regulation of GH3-cell function via adenosine A1 receptors. Inhibition of prolactin release, cyclic AMP production and inositol phosphate generation. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2848525&form=6&db=m Interaction of beta-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc- S49 lymphoma cells. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2848590&form=6&db=m Homologous and heterologous beta-adrenergic desensitization in hepatocytes. Additivity and effect of pertussis toxin. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2848845&form=6&db=m Pertussis toxin and pre-junctional alpha 2-adrenoreceptors in rat heart and vas deferens. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2849042&form=6&db=m Opioid receptors are coupled tightly to G proteins but loosely to adenylate cyclase in NG108-15 cell membranes. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2849044&form=6&db=m The new positive inotrope sulmazole inhibits the function of guanine nucleotide regulatory proteins by affecting GTP turnover. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2849336&form=6&db=m Muscarinic cholinergic inhibition of cyclic AMP accumulation in airway smooth muscle. Role of a pertussis toxin-sensitive protein. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2849413&form=6&db=m Modulation of bombesin-induced phosphatidylinositol hydrolysis in a small-cell lung-cancer cell line. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2849425&form=6&db=m Fluoroaluminates mimic muscarinic- and oxytocin-receptor-mediated generation of inositol phosphates and contraction in the intact guinea-pig myometrium. Role for a pertussis/cholera-toxin-insensitive G protein. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2849440&form=6&db=m Studies on opsonized zymozan, FMLP, carbachol, PMA and A23187 stimulated respiratory burst of human PMNLs. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2849676&form=6&db=m Negative and positive inotropic responses to muscarinic agonists in guinea pig and rat atria in vitro. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2849940&form=6&db=m Bradykinin-induced generation of inositol 1,4,5-trisphosphate in fibroblasts and neuroblastoma cells: effect of pertussis toxin, extracellular calcium, and down-regulation of protein kinase C. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2850027&form=6&db=m Stimulation of cardiac alpha receptors increases Na/K pump current and decreases gK via a pertussis toxin-sensitive pathway. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2850247&form=6&db=m Vasopressin induces breakdown of phosphoinositides in adrenal tumor Y-1 cells without a steroidogenic effect. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2850725&form=6&db=m Effect of prostaglandin F2 alpha on human parathyroid adenomas: evidence for uncoupling of parathyroid hormone secretion and cAMP accumulation. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2850795&form=6&db=m Second-messenger generation in PC12 cells. Interactions between cyclic AMP and Ca2+ signals. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2850843&form=6&db=m Evidence for pharmacologically distinct subsets of GABAB receptors. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2851813&form=6&db=m Pertussis toxin modulates dopamine inhibition of Na,K-ATPase activity in rat proximal convoluted tubule segments. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2851988&form=6&db=m Effect of pertussis toxin and neomycin on G-protein-regulated polyphosphoinositide phosphodiesterase. A comparison between HL60 membranes and permeabilized HL60 cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2852323&form=6&db=m Pertussis toxin pretreatment antagonizes the actions of mu- and delta-opiate agonists in hippocampal slices. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2853847&form=6&db=m GTP-binding proteins mediate the M2-muscarinic effect on the action potential in isolated sympathetic neurons of rabbits. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2854210&form=6&db=m The antiadrenergic effect of neuropeptide Y on the ventricular cardiomyocyte. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2854747&form=6&db=m The inhibitory guanine nucleotide regulatory protein modulates agonist-stimulated cAMP production in rat osteosarcoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2855081&form=6&db=m Human polymorphonuclear leukocyte activating factor isolated from Aleurites Fordii Hemsl. (Euphorbiaceae) seed. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2855189&form=6&db=m Effect of pertussis toxin on parathyroid hormone-stimulated cyclic AMP production in cultured kidney cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2856099&form=6&db=m Pre- and postsynaptic GABAB receptors in the hippocampus have different pharmacological properties. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2856219&form=6&db=m Biochemical properties of pertussis toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2856342&form=6&db=m The role of neutrophils in tissue localized cell-mediated immunologic responses: I. The intensity of contact-type and delayed-type hypersensitivity responses may be influenced by the extent of extracellular matrix degradation by neutrophil proteases. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2856714&form=6&db=m Mode of inhibition of renin release by angiotensin II. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2856941&form=6&db=m Pertussis toxin treatment blocks the inhibition of somatostatin and increases the stimulation by forskolin of cyclic AMP accumulation and adrenocorticotropin secretion from mouse anterior pituitary tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2857752&form=6&db=m Neutralizing antibodies to pertussis toxin in whooping cough. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2858206&form=6&db=m The inhibitory guanine nucleotide-binding regulatory subunit of adenylate cyclase has an adenylate cyclase-independent modulatory effect on ACTH secretion from mouse pituitary tumor cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2858396&form=6&db=m Effects of dexamethasone and indomethacin on the vascular beta 2-adrenolytic action of pertussis toxin in rats; a prostaglandin-mediated phenomenon. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2859292&form=6&db=m The inhibition of neutrophil granule enzyme secretion and chemotaxis by pertussis toxin. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2859515&form=6&db=m Pertussis toxin: a tool for studying the regulation of adenylate cyclase. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2859983&form=6&db=m Multiple mechanisms of somatostatin inhibition of adrenocorticotropin release from mouse anterior pituitary tumor cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2860059&form=6&db=m [Pathogenetic significance of Bordetella pertussis toxin] diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2860111&form=6&db=m Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2860668&form=6&db=m Pertussis toxin inhibits chemotactic peptide-stimulated generation of inositol phosphates and lysosomal enzyme secretion in human leukemic (HL-60) cells. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2861240&form=6&db=m Characterization of two adhesins of Bordetella pertussis for human ciliated respiratory-epithelial cells. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2861293&form=6&db=m Effect of prednisolone on the toxicity of Bordetella pertussis for mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2861569&form=6&db=m Pertussis toxin reverses adenosine inhibition of neuronal glutamate release. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2863173&form=6&db=m Pertussis toxin selectively abolishes hormone induced lowering of cytosolic calcium in GH3 cells. causal interaction,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2863730&form=6&db=m The effect of pertussis toxin on alpha-2-adrenoceptor-mediated pigment migration in fish melanophores. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2865257&form=6&db=m Pertussis toxin blocks both cyclic AMP-mediated and cyclic AMP-independent actions of somatostatin. Evidence for coupling of Ni to decreases in intracellular free calcium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2865327&form=6&db=m One-dimensional peptide mapping of the subunits of pertussis toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2865672&form=6&db=m Agonist and antagonist binding to alpha 2-adrenergic receptors in purified membranes from human platelets. Implications of receptor-inhibitory nucleotide-binding protein stoichiometry. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2867203&form=6&db=m Pertussis toxin blocks somatostatin inhibition of calcium mobilization and reduces the affinity of somatostatin receptors for agonists. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2867545&form=6&db=m Pertussis toxin is required for pertussis vaccine encephalopathy. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2869031&form=6&db=m Pertussis toxin blocks the inhibitory effects of somatostatin on cAMP-dependent vasoactive intestinal peptide and cAMP-independent thyrotropin releasing hormone-stimulated prolactin secretion of GH3 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2869405&form=6&db=m Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2869974&form=6&db=m Somatostatin and alpha 2-adrenergic agonists selectively inhibit vasopressin-induced cyclic AMP accumulation in MDCK cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2870912&form=6&db=m Prostaglandin F2 alpha and alpha-adrenergic agonists regulate parathyroid cell function via the inhibitory guanine nucleotide regulatory protein. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2871544&form=6&db=m Molecular cloning of pertussis toxin genes. diagnostic usage,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2871761&form=6&db=m Effects of insulin, adenosine, and prostaglandin on alpha-adrenergic-stimulated respiration in brown adipocytes. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2872097&form=6&db=m Genetic studies of the molecular basis of whooping cough. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2872098&form=6&db=m Cell surface antigens of Bordetella pertussis. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2872105&form=6&db=m Filamentous hemagglutinin and pertussis toxin promote adherence of Bordetella pertussis to cilia. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2872111&form=6&db=m Studies on phase variation in Bordetella pertussis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2872118&form=6&db=m Bordetella adenylate cyclase: host toxicity and diagnostic utility. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2872126&form=6&db=m Murine model for pertussis vaccine encephalopathy: role of the major histocompatibility complex; antibody to albumin and to Bordetella pertussis and pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2872127&form=6&db=m Protective antigens of Bordetella pertussis mouse-protection test against intracerebral and aerosol challenge of B. pertussis. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2872134&form=6&db=m Effect of heptakis (2,6-0-dimethyl)beta-cyclodextrin on cell growth and the production of pertussis toxin and filamentous hemagglutinin in Bordetella pertussis. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2872165&form=6&db=m Filamentous hemagglutinin has a major role in mediating adherence of Bordetella pertussis to human WiDr cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2872255&form=6&db=m Use of implantable intraperitoneal diffusion chambers to study Bordetella pertussis pathogenesis: growth and toxin production in vivo. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2872269&form=6&db=m Antigenic heterogeneity in subunit S1 of pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2872921&form=6&db=m Stimulation of the thiol-dependent ADP-ribosyltransferase and NAD glycohydrolase activities of Bordetella pertussis toxin by adenine nucleotides, phospholipids, and detergents. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2873059&form=6&db=m Activation of guanylate cyclase by E. coli heat-stable enterotoxin (STa). Modulation by NAD and pertussis toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2873570&form=6&db=m Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2875069&form=6&db=m Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. Withdrawal of GTP-dependent inhibition. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2875442&form=6&db=m Somatocrinin stimulates adenylate cyclase-Ns regulatory subunit in a GH3 cell-line: comparison with VIP. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2875890&form=6&db=m Vascular beta-adrenoceptor blocking activity of endotoxin and pertussis toxin from Bordetella pertussis in rats. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2875997&form=6&db=m Association of a solubilized prostaglandin E2 receptor from renal medulla with a pertussis toxin-reactive guanine nucleotide regulatory protein. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2876014&form=6&db=m Desensitization in rat parotid to beta-adrenergic agonists and counteracting effects of forskolin are conserved in membrane and detergent-solubilized adenylate cyclase catalyst activity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2876957&form=6&db=m Surface proteins of Bordetella pertussis: comparison of virulent and avirulent strains and effects of phenotypic modulation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2876983&form=6&db=m Protein kinase C enhances growth hormone releasing factor (1-40)-stimulated cyclic AMP levels in anterior pituitary. Actions of somatostatin and pertussis toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2876993&form=6&db=m Pertussis toxin inhibits retinoic acid-induced expression of tissue transglutaminase in macrophages. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2878883&form=6&db=m Bordetella pertussis adenylate cyclase: isolation and purification by calmodulin-sepharose 4B chromatography. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2878884&form=6&db=m Bordetella pertussis adenylate cyclase: effects of affinity-purified adenylate cyclase on human polymorphonuclear leukocyte functions. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2879065&form=6&db=m Transmembrane signalling of atrial natriuretic peptide in rat renal juxtaglomerular cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2879558&form=6&db=m Regulation of acetyl-CoA carboxylase by ADP-ribosylation. causal interaction,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2879895&form=6&db=m Newly synthesized catalytic and regulatory components of adenylate cyclase are expressed in neurites of cultured sympathetic neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2880863&form=6&db=m Phorbol ester and phospholipase C-induced growth hormone secretion from pituitary somatotroph adenoma cells in culture: effects of somatostatin, bromocriptine, and pertussis toxin. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2881344&form=6&db=m Mechanisms of action of antisecretory drugs. Studies on isolated canine fundic mucosal cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2881539&form=6&db=m Muscarinic-agonist and guanine nucleotide activation of polyphosphoinositide phosphodiesterase in isolated islet-cell membranes. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2881777&form=6&db=m Control of aldosterone production by angiotensin II is mediated by two guanine nucleotide regulatory proteins. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2881931&form=6&db=m Antitoxin in human pertussis immune globulins. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2882998&form=6&db=m A pertussis toxin substrate regulates alpha 1-adrenergic dependent phosphatidylinositol hydrolysis in cultured rat myocytes. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2883004&form=6&db=m Acellular pertussis vaccine in adults: adverse reactions and immune response. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2883124&form=6&db=m Detection of subunits of pertussis toxin in Tn5-induced Bordetella mutants deficient in toxin biological activity. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2883125&form=6&db=m Expression of the S-1 catalytic subunit of pertussis toxin in Escherichia coli. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2883239&form=6&db=m Use of erythromycin to prevent pertussis in newborns of mothers with pertussis. causal interaction,diagnostic usage,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2884169&form=6&db=m The construction of a cloning vector designed for gene replacement in Bordetella pertussis. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2884644&form=6&db=m Somatostatin prevents the desensitizing action of growth hormone-releasing factor on growth hormone release. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2885223&form=6&db=m Alpha 2-adrenergic inhibition of pancreatic islet glucose utilization is mediated by an inhibitory guanine nucleotide regulatory protein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2885321&form=6&db=m Divergent stimulatory and inhibitory actions of carbamoylcholine on gastric D-cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2886051&form=6&db=m Prevention of alpha 2-adrenergic inhibition on ADH action by pertussis toxin in rabbit CCT. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2886351&form=6&db=m Role of a protein regulating guanine nucleotide binding in phosphoinositide breakdown and calcium mobilization by bradykinin in neuroblastoma X glioma hybrid NG108-15 cells: effects of pertussis toxin and cholera toxin on receptor-mediated signal transduction. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2887161&form=6&db=m The potentiating effects of phorbol ester on ACTH-, cholera toxin-, and forskolin-induced cAMP production by cultured bovine adrenal cells is not mediated by the inactivation of alpha subunit of Gi protein. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2887235&form=6&db=m Inositol phosphate formation and chloride current responses induced by acetylcholine and serotonin through GTP-binding proteins in Xenopus oocyte after injection of rat brain messenger RNA. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2887245&form=6&db=m Pertussis toxin blocks presynaptic glutamate receptors--a novel 'glutamateB' receptor in the lobster neuromuscular synapse. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2887564&form=6&db=m Covalent cross-linking of prostaglandin E receptor from bovine adrenal medulla with a pertussis toxin-insensitive guanine nucleotide-binding protein. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2888113&form=6&db=m Dissociation of bradykinin-induced prostaglandin formation from phosphatidylinositol turnover in Swiss 3T3 fibroblasts: evidence for G protein regulation of phospholipase A2. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2888315&form=6&db=m Coupling of guanine nucleotide inhibitory protein to somatostatin receptors on pancreatic acinar membranes. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2888459&form=6&db=m Mechanisms for the stimulatory and inhibitory effects of carbamoylcholine on canine gastric D-cells. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2888733&form=6&db=m Construction and characterization of Bordetella pertussis toxin mutants. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2888765&form=6&db=m Mechanisms for direct inhibition of canine gastric parietal cells by somatostatin. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2888823&form=6&db=m Inhibition of monocyte oxidative responses by Bordetella pertussis adenylate cyclase toxin. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2889782&form=6&db=m Rapid induction of Thy-1 antigenic markers on keratinocytes and epidermal immune cells in the skin of mice following topical treatment with common preservatives used in topical medications and in foods. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2890084&form=6&db=m Increase in intradermal vascular permeability caused by pertussis toxin from Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2890244&form=6&db=m Acellular pertussis vaccine prepared by a simple extraction and toxoiding procedure. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2890515&form=6&db=m Somatostatin receptors on pituitary somatotrophs, thyrotrophs, and lactotrophs: pharmacological evidence for loose coupling to adenylate cyclase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2891042&form=6&db=m Pertussis toxin does not attenuate alpha 2-adrenoceptor mediated inhibition of noradrenaline release in mouse atria. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2891304&form=6&db=m Somatostatin inhibits cAMP-mediated cholinergic transmission in the myenteric plexus. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2892482&form=6&db=m Differential effect of Bordetella pertussis on experimental posterior uveitis in the black-hooded Lister rat. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2892859&form=6&db=m Biosynthesis of somatostatin in canine fundic D cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2894297&form=6&db=m Alpha 1-adrenergic stimulation of in vitro growth hormone release and cytosolic free Ca2+ in rat somatotrophs. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2894311&form=6&db=m Gi affects the agonist-binding properties of beta-adrenoceptors in the presence of Gs. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2894360&form=6&db=m Effects of adenylate cyclase toxin from Bordetella pertussis on human neutrophil interactions with Coccidioides immitis and Staphylococcus aureus. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2894453&form=6&db=m Inhibition of vasopressin-stimulated cyclic AMP accumulation by alpha-2 adrenoceptor agonists in isolated papillary collecting ducts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2894469&form=6&db=m Slight hyperinsulinaemia but no hypoglycaemia in pertussis patients. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2895005&form=6&db=m Differential effect of pertussis toxin on pre- and postjunctional alpha 2-adrenoceptors in the cardiovascular system of the pithed rat. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2896042&form=6&db=m Somatostatin inhibition of anterior pituitary adenylate cyclase activity: different sensitivity between male and female rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2896064&form=6&db=m A potassium conductance contributes to the action of somatostatin-14 to suppress ACTH secretion. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2896200&form=6&db=m Functional reconstitution of prostaglandin E receptor from bovine adrenal medulla with guanine nucleotide binding proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2896225&form=6&db=m Release of pertussis toxin and its interaction with outer-membrane antigens. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2896236&form=6&db=m Somatostatin inhibits cAMP-dependent and cAMP-independent calcium influx in the clonal pituitary tumor cell line AtT-20 through the same receptor population. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2896265&form=6&db=m Reversal of somatostatin inhibition of AVP-induced cAMP by pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2896289&form=6&db=m Evolutionary relationships in the genus Bordetella. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2896387&form=6&db=m ADP-ribosyltransferase activity of pertussis toxin and immunomodulation by Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2897370&form=6&db=m The purification and characterization of an acellular pertussis vaccine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2897691&form=6&db=m Positive regulation of pertussis toxin expression. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2898470&form=6&db=m Genetic analysis of a region of the Bordetella pertussis chromosome encoding filamentous hemagglutinin and the pleiotropic regulatory locus vir. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2898484&form=6&db=m Specific immunoglobulin A to Bordetella pertussis antigens in mucosal secretion for rapid diagnosis of whooping cough. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2898854&form=6&db=m Augmentation of glucose induced insulin secretion by pertussis vaccine, phentolamine and benextramine: involvement of mechanisms additional to prevention of the inhibitory actions of catecholamines in rats. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2898895&form=6&db=m Functional somatostatin receptors on a rat pancreatic acinar cell line. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2899027&form=6&db=m Antibody response to pertussis toxin in patients with clinical pertussis measured by enzyme-linked immunosorbent assay. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2899524&form=6&db=m Cholinergic stimulation of phosphoinositide hydrolysis in rat anterior pituitary. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2900008&form=6&db=m Phorbol esters and thyroliberin have distinct actions regarding stimulation of prolactin secretion and activation of adenylate cyclase in rat pituitary tumour cells (GH4C1 cells). causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2900331&form=6&db=m Pertussis toxin modifies the characteristics of both the inhibitory GTP binding proteins and the somatostatin receptor in anterior pituitary tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2900606&form=6&db=m Mechanism of alpha 2-adrenoceptor agonist-induced diuresis. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2900845&form=6&db=m New, practical approach to detecting antibody to pertussis toxin for public health and clinical laboratories. diagnostic usage,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2901110&form=6&db=m Mechanism of synaptic inhibition by noradrenaline acting at alpha 2-adrenoceptors. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2901161&form=6&db=m Signal transduction in cells following binding of chemoattractants to membrane receptors. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2901174&form=6&db=m [Cloning and gene expression of the leukocytosis (lymphocytosis) stimulating factor of Bordatella pertussis in Escherichia coli by bringing the PT genes close to the lactose promoter of plasmid pUC19] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2901175&form=6&db=m [Detection of the gene sequences of the leukocytosis (lymphocytosis)-stimulating factor of Bordetella pertussis in Bordetella parapertussis and Bordetella bronchiseptica by using molecular hybridization] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2901703&form=6&db=m Pertussis toxin blocks the effects of alpha 2-agonists and antagonists on locus coeruleus activity in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2902185&form=6&db=m Dissecting human T cell responses against Bordetella species. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2902632&form=6&db=m Subunit S1 of pertussis toxin: mapping of the regions essential for ADP-ribosyltransferase activity. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2902802&form=6&db=m Pertussis toxin-sensitive cholinergic inhibition of somatostatin release from canine D-cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2902959&form=6&db=m Na+/H+ exchange and the regulation of intracellular pH in polymorphonuclear leukocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2903178&form=6&db=m Evaluation of serologic assays for diagnosis of whooping cough. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2903539&form=6&db=m Surface proteins of Bordetella pertussis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2904197&form=6&db=m All species of the genus Bordetella contain genes for pertussis toxin of Bordetella pertussis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2904201&form=6&db=m [Physicochemical and biological characteristics of preparations of an antigenic complex isolated from the cultivation medium of Bordetella pertussis] causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2904368&form=6&db=m Hormone-sensitive adenylate cyclase of prolactin-producing rat pituitary adenoma (GH4C1) cells: molecular organization. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2904442&form=6&db=m Lipopolysaccharides in a traditional pertussis vaccine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2904640&form=6&db=m Expression and secretion of pertussis toxin subunit S1 in Bacillus subtilis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2904771&form=6&db=m Tonic inhibition of renal response to vasopressin by a pertussis toxin substrate. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2904800&form=6&db=m Virulence factors of Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2904889&form=6&db=m Somatostatin activates glibenclamide-sensitive and ATP-regulated K+ channels in insulinoma cells via a G-protein. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2905268&form=6&db=m Disparate effects of neuropeptide Y and clonidine on the excretion of sodium and water in the rat. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2905773&form=6&db=m Multiple pertussis toxin substrates as candidates for regulatory G proteins of adenylate cyclase coupled to the somatostatin receptor in primary rat astrocytes. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2906137&form=6&db=m G-proteins, the inositol lipid signalling pathway, and secretion. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2906148&form=6&db=m Transmembrane signalling pathways initiating cell growth in fibroblasts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2906727&form=6&db=m Purification of pertussis toxin. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2907913&form=6&db=m Neuropeptide Y modulates neurotransmitter release and Ca2+ currents in rat sensory neurons. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2908118&form=6&db=m Interaction of Bordetella pertussis virulence components with neutrophils: effect on chemiluminescence induced by a chemotactic peptide and by intact bacteria. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2908233&form=6&db=m Actions of pertussis toxin on the inhibitory effects of dopamine and somatostatin on prolactin and growth hormone release from ovine anterior pituitary cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2908524&form=6&db=m Molecular cloning and analysis of P. 69, a vir-controlled protein from Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2908528&form=6&db=m Characterization and clinical study on the acellular pertussis vaccine produced by a combination of column purified pertussis toxin and filamentous hemagglutinin. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2908529&form=6&db=m Aerosol infection test for evaluation of pertussis vaccine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2908530&form=6&db=m Further characterization of Japanese acellular pertussis vaccine prepared in 1988 by 6 Japanese manufacturers. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2908558&form=6&db=m Subunit structure and enzymic activity of pertussis toxin. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2910841&form=6&db=m Analysis of calcium homeostasis in activated human polymorphonuclear leukocytes. Evidence for two distinct mechanisms for lowering cytosolic calcium. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2913212&form=6&db=m Aplysia synaptosomes. I. Preparation and biochemical and morphological characterization of subcellular membrane fractions. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2923133&form=6&db=m Characterization of phospholipase C activity of the plasma membrane and cytosol of an osteoblast-like cell line. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2924077&form=6&db=m Effects of pertussis toxin on the behavioural and ECoG spectrum changes induced by clonidine and yohimbine after their microinfusion into the locus coeruleus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2925275&form=6&db=m Use of the Membrane Invasion Culture System (MICS) as a screen for anti-invasive agents. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2927400&form=6&db=m Studies of the antigenic structure of two cross-reacting proteins, pertussis and cholera toxins, using synthetic peptides. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2929238&form=6&db=m Rat adipose tissue adenosine sensitivity and adenosine content after subcutaneous administration of N6-(phenylisopropyl)adenosine. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2930541&form=6&db=m Lack of effect of pertussis toxin on TNF-alpha-induced formation of reactive oxygen intermediates by human neutrophils. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2940083&form=6&db=m Is a guanine nucleotide-binding protein involved in excitation-contraction coupling in skeletal muscle? unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2944002&form=6&db=m Endogenous ADP-ribosylation of Gs subunit and autonomous regulation of adenylate cyclase. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2946691&form=6&db=m Solubilization of the vasopressin receptor from rat liver plasma membranes. Evidence for a receptor X GTP-binding protein complex. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2947938&form=6&db=m Evidence for two different stimulatory adenylate cyclase coupling mechanisms in rat renal papilla. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2950093&form=6&db=m Cholera toxin blocks glucagon-mediated inhibition of the liver plasma membrane (Ca2+-Mg2+)-ATPase. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2951497&form=6&db=m Pertussis toxin attenuates D2 inhibition and enhances D1 stimulation of adenylate cyclase by dopamine in rat striatum. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2955848&form=6&db=m Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2956893&form=6&db=m Inhibition of epithelial Na+ transport by atriopeptin, protein kinase c, and pertussis toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2956953&form=6&db=m Partial characterization of GTP-binding proteins in Neurospora. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2958548&form=6&db=m Pertussis toxin triggers rapid second messenger production in human T lymphocytes. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2960456&form=6&db=m Suppression of the cytotoxic T-lymphocyte response in mice by pertussis toxin. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2962594&form=6&db=m Monoclonal antibody against pertussis toxin: relationship between toxin neutralization and mouse protection activities. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2963816&form=6&db=m Vasopressin induces V1 receptors to activate phosphatidylinositol- and phosphatidylcholine-specific phospholipase C and stimulates the release of arachidonic acid by at least two pathways in the smooth muscle cell line, A-10. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2963967&form=6&db=m Dopamine inhibition of proopiomelanocortin gene expression in the intermediate lobe of the pituitary. Interactions with corticotropin-releasing factor and the beta-adrenergic receptors and the adenylate cyclase system. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2967866&form=6&db=m Pertussis toxin inhibits human neutrophil responses mediated by the 42-kilodalton IgG Fc receptor. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2968346&form=6&db=m Norepinephrine down-regulates the activity of protein S on endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2969344&form=6&db=m [Modulation of the action of interferon-gamma by protein G] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2970430&form=6&db=m The effects of pertussis toxin on human T lymphocytes. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2972552&form=6&db=m 5-Hydroxytryptamine1A receptors are linked to a Gi-adenylate cyclase complex in rat hippocampus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2974120&form=6&db=m The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2981400&form=6&db=m Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2982667&form=6&db=m Comparative effects of cholera and Bordetella pertussis toxins on cyclic AMP and GTP levels and on lipolysis in rat adipocytes incubated in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2982668&form=6&db=m Pertussis toxin facilitates the progesterone-induced maturation of Xenopus oocyte. Possible role of protein phosphorylation. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2982805&form=6&db=m The inhibitory guanine nucleotide-binding protein (Ni) purified from bovine brain is a high affinity GTPase. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2982825&form=6&db=m Fat cell adenylate cyclase system. Enhanced inhibition by adenosine and GTP in the hypothyroid rat. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2982826&form=6&db=m Adenine nucleotides directly stimulate pertussis toxin. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2983319&form=6&db=m Association of the N-formyl-Met-Leu-Phe receptor in human neutrophils with a GTP-binding protein sensitive to pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2983701&form=6&db=m Pertussis but not cholera toxin inhibits the stimulated increase in actin association with the cytoskeleton in rabbit neutrophils: role of the "G proteins" in stimulus-response coupling. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2983721&form=6&db=m Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2983985&form=6&db=m Solubilization from rat pancreatic plasma membranes of a cholecystokinin (CCK) agonist-receptor complex interacting with guanine nucleotide regulatory proteins coexisting in the same macromolecular system. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2985432&form=6&db=m Pertussis toxin inhibits chemotactic factor-induced phospholipase C stimulation and lysosomal enzyme secretion in rabbit neutrophils. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2985570&form=6&db=m Heterologous desensitization of adenylate cyclase with prostaglandin E1 alters sensitivity to inhibitory as well as stimulatory agonists. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2986551&form=6&db=m Dual pathways of receptor-mediated cyclic GMP generation in NG108-15 cells as differentiated by susceptibility to islet-activating protein, pertussis toxin. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2987206&form=6&db=m Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2987230&form=6&db=m Action of the cardiac alpha 1-adrenergic receptor. Activation of cyclic AMP degradation. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2988509&form=6&db=m Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2989409&form=6&db=m Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2990462&form=6&db=m Platelet-activating factor mediated effects on human neutrophil function are inhibited by pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2991740&form=6&db=m Effects of pertussis toxin on cAMP and cGMP responses to carbamylcholine in N1E-115 neuroblastoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2991940&form=6&db=m Regulation of cyclic AMP accumulation in lymphoid cells. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2992293&form=6&db=m Attenuation of muscarinic cholinergic inhibition by islet-activating protein in the heart. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2992480&form=6&db=m Unique inhibitory profile of platelet activating factor induced calcium mobilization, polyphosphoinositide turnover and granule enzyme secretion in rabbit neutrophils towards pertussis toxin and phorbol ester. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2992496&form=6&db=m Pertussis toxin reversal of the antilipolytic action of insulin in rat adipocytes in the presence of forskolin does not involve cyclic AMP. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2994230&form=6&db=m Acquisition by innervated cardiac myocytes of a pertussis toxin-specific regulatory protein linked to the alpha 1-receptor. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2994873&form=6&db=m Inhibition of ACTH secretion in mouse pituitary tumor cells by activation of muscarinic cholinergic receptors. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2995338&form=6&db=m Mechanism of inhibition of transducin GTPase activity by fluoride and aluminum. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2995384&form=6&db=m Prevention of the agonist binding to gamma-aminobutyric acid B receptors by guanine nucleotides and islet-activating protein, pertussis toxin, in bovine cerebral cortex. Possible coupling of the toxin-sensitive GTP-binding proteins to receptors. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2996426&form=6&db=m Components of purified sarcolemma from porcine skeletal muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2996539&form=6&db=m Evidence for a functionally active inhibitory guanine nucleotide-binding regulatory protein in the swine ovary. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2997225&form=6&db=m Effect of pertussis toxin treatment on the down-regulation of opiate receptors in neuroblastoma X glioma NG108-15 hybrid cells. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2997284&form=6&db=m Human fat cell lipolysis is primarily regulated by inhibitory modulators acting through distinct mechanisms. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2997705&form=6&db=m Calcium mobilization and signal transduction in the neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2998486&form=6&db=m [Effect of bacterial toxins on the GTPase activity of transducin from bovine rod outer segments] ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2999136&form=6&db=m Inhibition by islet-activating protein of a chemotactic peptide-induced early breakdown of inositol phospholipids and Ca2+ mobilization in guinea pig neutrophils. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2999149&form=6&db=m Role of Ni in coupling angiotensin receptors to inhibition of adenylate cyclase in hepatocytes. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2999238&form=6&db=m Inhibition of lymphocyte and neutrophil chemotaxis by pertussis toxin. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3000373&form=6&db=m Calcium mobilization in fluoride activated human neutrophils. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3001714&form=6&db=m A pertussis toxin-sensitive GTP-binding protein in the human neutrophil regulates multiple receptors, calcium mobilization, and lectin-induced capping. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3002816&form=6&db=m Pertussis toxin separates two muscarinic receptor-effector mechanisms in the striatum. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3004405&form=6&db=m Rat fat-cells have three types of adenosine receptors (Ra, Ri and P). Differential effects of pertussis toxin. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3005034&form=6&db=m Bradykinin stimulates GTP hydrolysis in NG108-15 membranes by a high-affinity, pertussis toxin-insensitive GTPase. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3005271&form=6&db=m Thyrotropin-releasing hormone activates a Ca2+-dependent polyphosphoinositide phosphodiesterase in permeable GH3 cells. GTP gamma S potentiation by a cholera and pertussis toxin-insensitive mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3005316&form=6&db=m Angiotensin II and dopamine modulate both cAMP and inositol phosphate productions in anterior pituitary cells. Involvement in prolactin secretion. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3005329&form=6&db=m Adenine nucleotides promote dissociation of pertussis toxin subunits. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3005789&form=6&db=m Pertussis toxin enhances the beta-adrenergic and blocks the alpha 2-adrenergic regulation of renin secretion in renal cortical slices. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3005828&form=6&db=m Effect of islet-activating pertussis toxin on the binding characteristics of Ca2+-mobilizing hormones and on agonist activation of phosphorylase in hepatocytes. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3005832&form=6&db=m Uncoupling of gamma-aminobutyric acid B receptors from GTP-binding proteins by N-ethylmaleimide: effect of N-ethylmaleimide on purified GTP-binding proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3007118&form=6&db=m Pertussis toxin inhibits thrombin-induced activation of phosphoinositide hydrolysis and Na+/H+ exchange in hamster fibroblasts. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3007212&form=6&db=m Treatment of rabbit neutrophils with phorbol esters results in increased ADP-ribosylation catalyzed by pertussis toxin and inhibition of the GTPase stimulated by fMet-Leu-Phe. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3008747&form=6&db=m Pertussis toxin does not prevent alpha adrenergic stimulated breakdown of phosphoinositides or respiration in brown adipocytes. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3009162&form=6&db=m Dexamethasone effects on beta-adrenergic receptors and adenylate cyclase regulatory proteins Gs and Gi in ROS 17/2.8 cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3010077&form=6&db=m Neurotensin-mediated inhibition of cyclic AMP formation in neuroblastoma N1E115 cells: involvement of the inhibitory GTP-binding component of adenylate cyclase. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3011106&form=6&db=m Pertussis toxin effects on adenylate cyclase activity, cyclic AMP accumulation and lipolysis in adipocytes from hypothyroid, euthyroid and hyperthyroid rats. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3011502&form=6&db=m Leukotriene B4 stimulation of phosphatidylinositol turnover in macrophages and inhibition by pertussis toxin. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3011523&form=6&db=m Pertussis toxin as a probe of neutrophil activation. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3011906&form=6&db=m A guanine nucleotide regulatory protein controls polyphosphoinositide metabolism, Ca2+ mobilization, and cellular responses to chemoattractants in human monocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3012078&form=6&db=m Effect of cholera toxin and pertussis toxin on opioid tolerance and dependence in the guinea-pig myenteric plexus. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3012529&form=6&db=m Reduced hormone-stimulated adenylate cyclase activity in NIH-3T3 cells expressing the EJ human bladder ras oncogene. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3013159&form=6&db=m Activation of muscarinic receptors in PC12 cells. Correlation between cytosolic Ca2+ rise and phosphoinositide hydrolysis. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3013688&form=6&db=m Increased sensitivity of fat cell adenylate cyclase to stimulatory agonists during fasting is not related to impaired inhibitory coupling system. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3013886&form=6&db=m Coupling of the thyrotropin-releasing hormone receptor to phospholipase C by a GTP-binding protein distinct from the inhibitory or stimulatory GTP-binding protein. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3014249&form=6&db=m Vascular vasopressin receptors mediate phosphatidylinositol turnover and calcium efflux in an established smooth muscle cell line. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3015672&form=6&db=m Interaction of GTP-binding proteins with calmodulin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3015684&form=6&db=m Effects of thrombin, phorbol myristate acetate and prostaglandin D2 on 40-41 kDa protein that is ADP ribosylated by pertussis toxin in platelets. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3015920&form=6&db=m Thyrotropin-releasing hormone stimulation of polyphosphoinositide hydrolysis in GH3 cell membranes is GTP dependent but insensitive to cholera or pertussis toxin. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3015921&form=6&db=m Guanine nucleotide effects on catecholamine secretion from digitonin-permeabilized adrenal chromaffin cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3016048&form=6&db=m Inhibition of thyrotropin-stimulated adenosine 3',5'-monophosphate formation in rat thyroid cells by an adenosine analog. Evidence that the inhibition is mediated by the putative inhibitory guanine nucleotide regulatory protein. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3017298&form=6&db=m The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3017343&form=6&db=m A pertussis/choleratoxin-sensitive N protein may mediate chemoattractant receptor signal transduction. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3017932&form=6&db=m Inhibitory action of forskolin on adenylate cyclase activity and cyclic AMP generation. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3017978&form=6&db=m Gonadotropin-releasing hormone activates a rapid Ca2+-independent phosphodiester hydrolysis of polyphosphoinositides in pituitary gonadotrophs. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3018082&form=6&db=m Characterization of the plasma membrane bound GTPase from rabbit neutrophils. I. Evidence for an Ni-like protein coupled to the formyl peptide, C5a, and leukotriene B4 chemotaxis receptors. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3019344&form=6&db=m Evidence that thyrotropin-releasing hormone-induced increases in GTPase activity and phosphoinositide metabolism in GH3 cells are mediated by a guanine nucleotide-binding protein other than Gs or Gi. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3019768&form=6&db=m Use of fluoride ion as a probe for the guanine nucleotide-binding protein involved in the phosphoinositide-dependent neutrophil transduction pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3020100&form=6&db=m Phorbol ester-induced augmentation and inhibition of epinephrine-stimulated adenylate cyclase in S49 lymphoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3020540&form=6&db=m Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3021235&form=6&db=m Effect of pertussis toxin on the phosphodiesteratic cleavage of the polyphosphoinositides by guanosine 5'-O-thiotriphosphate and thrombin in permeabilized human platelets. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3021789&form=6&db=m Role of guanine nucleotide regulatory protein in polyphosphoinositide degradation and activation of phagocytic leukocytes by chemoattractants. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3021882&form=6&db=m Biochemical events associated with the stimulation of rabbit neutrophils by platelet-activating factor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3023016&form=6&db=m Stimulation of luteinizing hormone (LH) release and phospholipid breakdown by guanosine triphosphate in permeabilized pituitary gonadotropes: antagonist action suggests association of a G protein and gonadotropin-releasing hormone receptor. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3023367&form=6&db=m Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. Evaluation of its contribution to platelet activation and comparisons with the adenylate cyclase inhibitory protein, Gi. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3024080&form=6&db=m Neurotoxicity of Bordetella pertussis. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3024568&form=6&db=m A dose-response study of forskolin, stimulatory hormone, and guanosine triphosphate analog on adenylate cyclase from several sources. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3024620&form=6&db=m Pertussis toxin abolishes angiotensin II-induced phosphoinositide hydrolysis and prostaglandin synthesis in rat renal mesangial cells. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3024718&form=6&db=m Immunochemical detection of guanine nucleotide binding proteins mono-ADP-ribosylated by bacterial toxins. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3024727&form=6&db=m Cytoplasmic pH regulation in activated human neutrophils: effects of adenosine and pertussis toxin on Na+/H+ exchange and metabolic acidification. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3025201&form=6&db=m Light activation of phospholipase A2 in rod outer segments of bovine retina and its modulation by GTP-binding proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3025276&form=6&db=m NADP+ enhances cholera and pertussis toxin-catalyzed ADP-ribosylation of membrane proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3025278&form=6&db=m Muscarinic cholinergic receptor-induced enhancement of PGE1-stimulated cAMP accumulation in neuroblastoma X glioma cells: prevention by pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3026309&form=6&db=m Thyroliberin action in pituitary cells is not inhibited by pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3026330&form=6&db=m Evidence for two GTPases activated by thrombin in membranes of human platelets. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3026344&form=6&db=m Role of a pertussis toxin substrate in the control of lectin-induced cap formation in human neutrophils. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3026350&form=6&db=m Sensitivity of adipocyte lipolysis to stimulatory and inhibitory agonists in hypothyroidism and starvation. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3027097&form=6&db=m Regulation of neutrophil NADPH oxidase activation in a cell-free system by guanine nucleotides and fluoride. Evidence for participation of a pertussis and cholera toxin-insensitive G protein. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3027486&form=6&db=m Pertussis toxin reverses adenosine receptor-mediated inhibition of renin secretion in rat renal cortical slices. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3027523&form=6&db=m Alpha 1-adrenergic receptor-linked guanine nucleotide-binding protein in muscle and kidney epithelial cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3028373&form=6&db=m Leukotriene B4 stimulation of phagocytes results in the formation of inositol 1,4,5-trisphosphate. A second messenger for Ca2+ mobilization. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3028381&form=6&db=m Role of pertussis toxin sensitive G proteins in the alpha 1 adrenergic receptor but not in the thyrotropin receptor mediated activation of membrane phospholipases and iodide fluxes in FRTL-5 thyroid cells. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3028404&form=6&db=m Regulation of membrane associated protein kinase C activity by guanine nucleotide in rabbit peritoneal neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3029056&form=6&db=m Further evidence for a phospholipase C-coupled G protein in hamster fibroblasts. Induction of inositol phosphate formation by fluoroaluminate and vanadate and inhibition by pertussis toxin. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3029057&form=6&db=m Coupling between phosphoinositide breakdown and early mitogenic events in fibroblasts. Studies with fluoroaluminate, vanadate, and pertussis toxin. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3029113&form=6&db=m Neuropeptide Y inhibits cardiac adenylate cyclase through a pertussis toxin-sensitive G protein. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3030132&form=6&db=m Effect of N6-(L-2-phenylisopropyl)adenosine and insulin on cAMP metabolism in 3T3-L1 adipocytes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3030399&form=6&db=m Structure-activity analysis of the activation of pertussis toxin. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3030860&form=6&db=m A cholera toxin-sensitive G-protein stimulates exocytosis in sea urchin eggs. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3031034&form=6&db=m Pertussis toxin attenuates atrial natriuretic factor-mediated inhibition of adenylate cyclase. Involvement of inhibitory guanine nucleotide regulatory protein. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3031036&form=6&db=m Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3031135&form=6&db=m Inositol 1,4,5-triphosphate-induced granule secretion in platelets. Evidence that the activation of phospholipase C mediated by platelet thromboxane receptors involves a guanine nucleotide binding protein-dependent mechanism distinct from that of thrombin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3031579&form=6&db=m Pertussis toxin inhibits negative inotropic and negative chronotropic muscarinic cholinergic effects on the heart. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3031676&form=6&db=m Protein kinase C activation enhances cAMP accumulation in Swiss 3T3 cells: inhibition by pertussis toxin. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3032170&form=6&db=m G-protein dissociation, GTP-GDP exchange and GTPase activity in control and PMA treated neutrophils stimulated by fMet-Leu-Phe. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3032362&form=6&db=m Pertussis toxin or 8-bromo-cAMP block inhibition of the acoustic startle response by the alpha 2-adrenergic agonist ST-91. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3032571&form=6&db=m Control of cyclic adenosine 3',5'-monophosphate production in osteoclasts: calcitonin-induced persistent activation and homologous desensitization of adenylate cyclase. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3032649&form=6&db=m Effects of pertussis toxin on the alpha 2-adrenoceptor-inhibitory GTP-binding protein-adenylate cyclase system in rat brain: pharmacological and neurochemical studies. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3032660&form=6&db=m Pertussis toxin does not inhibit the alpha 1-adrenoceptor-mediated effect on inositol phosphate production in the heart. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3032757&form=6&db=m Effect of dihydroergocryptine and dihydroergocristine on cyclic AMP accumulation and prolactin release in vitro: evidence for a dopaminomimetic action. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3032838&form=6&db=m Regulation of lens cyclic nucleotide metabolism by Ca2+ plus calmodulin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3032956&form=6&db=m Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3033510&form=6&db=m Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3033564&form=6&db=m Suppressing effect of pertussis toxin on clonidine-induced inhibition of noradrenaline release from cerebral cortical slices of rats. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3034673&form=6&db=m Inhibitory effects of pertussis toxin on a depolarization-evoked Ca2+ influx in NG108-15 cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3034674&form=6&db=m Insulin stimulates a novel GTPase activity in human platelets. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3034695&form=6&db=m Sensitization of adrenocortical cell adenylate cyclase activity to ACTH by angiotensin II and activators of protein kinase C. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3035093&form=6&db=m Activation of dopamine receptors does not affect phosphoinositide turnover in NCB-20 cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3036141&form=6&db=m Chemotactic peptide, calcium and guanine nucleotide regulation of phospholipase C activity in membranes from DMSO-differentiated HL60 cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3036146&form=6&db=m Signalling for increased cytoskeletal actin in neutrophils. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3036863&form=6&db=m Regulation of thyrotropin-releasing hormone receptor binding and phospholipase C activation by a single GTP-binding protein. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3037392&form=6&db=m Evidence against a role of a pertussis toxin-sensitive guanine nucleotide-binding protein in the alpha 1-adrenoceptor-mediated positive inotropic effect in the heart. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3038542&form=6&db=m Thyrotropin effect on the availability of Ni regulatory protein in FRTL-5 rat thyroid cells to ADP-ribosylation by pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3038612&form=6&db=m Pertussis toxin distinguishes between muscarinic receptor-mediated inhibition of adenylate cyclase and stimulation of phosphoinositide hydrolysis in Flow 9000 cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3038620&form=6&db=m A novel cholera toxin-sensitive G-protein (Gc) regulating receptor-mediated phosphoinositide signalling in human pituitary clonal cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3039339&form=6&db=m Heterologous regulations of cAMP responses in pregnant rat myometrium. Evolution from a stimulatory to an inhibitory prostaglandin E2 and prostacyclin effect. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3039340&form=6&db=m Compartmentation of alpha 2-adrenergic receptors in human erythroleukemia (HEL) cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3039979&form=6&db=m Inhibition of bombesin-induced mitogenesis by pertussis toxin: dissociation from phospholipase C pathway. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3040169&form=6&db=m Alpha 2-adrenergic receptors mediate inhibition of cyclic AMP production in neurons in primary culture. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3040295&form=6&db=m Pertussis toxin-insensitive phosphoinositide hydrolysis, membrane depolarization, and positive inotropic effect of carbachol in chick atria. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3040750&form=6&db=m Possible involvement of a GTP-binding protein, the substrate of islet-activating protein, in receptor-mediated signaling responsible for cell proliferation. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3040818&form=6&db=m Insulin stimulation of cyclic AMP phosphodiesterase is independent from the G-protein pathways involved in adenylate cyclase regulation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3040912&form=6&db=m Stimulation of inositol phosphate production by neurotensin in neuroblastoma N1E115 cells: implication of GTP-binding proteins and relationship with the cyclic GMP response. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3043367&form=6&db=m Primary immunization of infants with an acellular pertussis vaccine in a double-blind randomized clinical trial. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3045244&form=6&db=m Role of the adrenal medulla in stress-induced hyperinsulinaemia in normal mice and in mice infected with Bordetella pertussis or treated with pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3045568&form=6&db=m Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HT1B receptors coupled to a Gi-protein. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3049149&form=6&db=m Differential sensitivity to pertussis toxin of 3T3 cells transformed with different oncogenes. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3059353&form=6&db=m Multiple signaling pathways control stimulus-secretion coupling in rat peritoneal mast cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3066348&form=6&db=m Regulation of glucose carrier activity by AlCl3 and phospholipase C in fat-cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3067125&form=6&db=m Blockade of a late inhibitory postsynaptic potential in hippocampal CA3 neurons in vitro reveals a late depolarizing potential that is augmented by pentobarbital. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3078801&form=6&db=m Pertussis in adults: possible use of booster doses for control. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3078805&form=6&db=m Animal models for pertussis vaccine neurotoxicity. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3080332&form=6&db=m The GTP-binding regulatory proteins of neuroblastoma x glioma, NG108-15, and glioma, C6, cells. Immunochemical evidence of a pertussis toxin substrate that is neither Ni nor No. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3080338&form=6&db=m Sequence analysis of bovine retinal S-antigen. Relationships with alpha-transducin and G-proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3080417&form=6&db=m Subunit interactions of native and ADP-ribosylated alpha 39 and alpha 41, two guanine nucleotide-binding proteins from bovine cerebral cortex. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3080428&form=6&db=m Pertussis toxin prevents homologous desensitization of adenylate cyclase in cultured renal epithelial cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3081891&form=6&db=m Bradykinin-activated transmembrane signals are coupled via No or Ni to production of inositol 1,4,5-trisphosphate, a second messenger in NG108-15 neuroblastoma-glioma hybrid cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3082880&form=6&db=m Mechanisms for inhibition of the catalytic activity of adenylate cyclase by the guanine nucleotide-binding proteins serving as the substrate of islet-activating protein, pertussis toxin. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3082894&form=6&db=m Is a rise in intracellular concentration of free calcium necessary or sufficient for stimulated cytoskeletal-associated actin? ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3083047&form=6&db=m Interaction of the inhibitory GTP regulatory component with soluble cerebral cortical adenylate cyclase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3083411&form=6&db=m Pertussis toxin or phorbol 12-myristate 13-acetate can distinguish between epidermal growth factor- and angiotensin-stimulated signals in hepatocytes. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3084483&form=6&db=m Functional interaction of purified muscarinic receptors with purified inhibitory guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3086888&form=6&db=m Go, a guanine nucleotide-binding protein: immunohistochemical localization in rat brain resembles distribution of second messenger systems. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3087783&form=6&db=m Pertussis toxin alters the growth characteristics of Swiss 3T3 cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3087970&form=6&db=m Two guanine nucleotide-binding proteins in rat brain serving as the specific substrate of islet-activating protein, pertussis toxin. Interaction of the alpha-subunits with beta gamma-subunits in development of their biological activities. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3089334&form=6&db=m [Inhibitory effect of pertussis toxin on the metabolism of guanine nucleotides in transducin from bovine outer rod segments] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3090044&form=6&db=m The interaction of nucleotides with pertussis toxin. Direct evidence for a nucleotide binding site on the toxin regulating the rate of ADP-ribosylation of Ni, the inhibitory regulatory component of adenylyl cyclase. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3090454&form=6&db=m Role of guanine nucleotide-binding protein in the regulation by adenosine of cardiac potassium conductance and force of contraction. Evaluation with pertussis toxin. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3091021&form=6&db=m Spermatozoa contain a guanine nucleotide-binding protein ADP-ribosylated by pertussis toxin. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3091265&form=6&db=m Dual effects of pertussis toxin on lymphoid cells in culture. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3091591&form=6&db=m Direct evidence for involvement of a guanine nucleotide-binding protein in chemotactic peptide-stimulated formation of inositol bisphosphate and trisphosphate in differentiated human leukemic (HL-60) cells. Reconstitution with Gi or Go of the plasma membranes ADP-ribosylated by pertussis toxin. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3092824&form=6&db=m Rat heart cell membranes contain three substrates for cholera toxin-catalyzed ADP-ribosylation and a single substrate for pertussis toxin-catalyzed ADP-ribosylation. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3093086&form=6&db=m Mechanism by which pertussis toxin breaks unresponsiveness of delayed-type hypersensitivity to sheep red blood cells in mice. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3094005&form=6&db=m Islet-activating protein inhibits leukotriene D4- and leukotriene C4- but not bradykinin- or calcium ionophore-induced prostacyclin synthesis in bovine endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3095144&form=6&db=m Guanine nucleotide-binding protein in sea urchin eggs serving as the specific substrate of islet-activating protein, pertussis toxin. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3095921&form=6&db=m Pertussis toxin inhibition of B cell and macrophage responses to bacterial lipopolysaccharide. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3096316&form=6&db=m Inhibition of calcium transients in cultured vascular smooth muscle cells by pertussis toxin. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3096319&form=6&db=m Relationship between the inhibition of adenylate cyclase by pentobarbital and the functional coupling of Ns and the catalytic unit. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3096331&form=6&db=m The role of guanyl nucleotide binding proteins in the formation of inositol phosphates in adrenal glomerulosa cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3096694&form=6&db=m Calcium-controlled secretion is effected through a guanine nucleotide regulatory protein in parathyroid cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3097538&form=6&db=m GTP-binding proteins associated with serotonin-activated adenylate cyclase in Fasciola hepatica. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3098737&form=6&db=m Regulation of ligand-receptor dynamics by guanine nucleotides. Real-time analysis of interconverting states for the neutrophil formyl peptide receptor. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3098931&form=6&db=m Biochemical and physical analyses of newly synthesized muscarinic acetylcholine receptors in cultured embryonic chicken cardiac cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3099111&form=6&db=m Influence of pertussis toxin on the effects of guanine nucleotide on adenylate cyclase in rat striatal membranes. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3099763&form=6&db=m Thrombin, unlike vasopressin, appears to stimulate two distinct guanine nucleotide regulatory proteins in human platelets. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3099783&form=6&db=m Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3100295&form=6&db=m The regulation of adenylate cyclase by guanine nucleotides in Dictyostelium discoideum membranes. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3100330&form=6&db=m Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3100336&form=6&db=m Pertussis toxin inhibits the angiotensin II and serotonin-induced rise of free cytoplasmic calcium in cultured smooth muscle cells from rat aorta. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3100533&form=6&db=m Induction of the fibrinogen receptor on human platelets by intracellular mediators. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3100640&form=6&db=m Diacylglycerol mass measurements in stimulated HL-60 phagocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3102471&form=6&db=m Interaction of GTP-binding regulatory proteins with chemosensory receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3103134&form=6&db=m Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3103610&form=6&db=m G-proteins of fat-cells. Role in hormonal regulation of intracellular inositol 1,4,5-trisphosphate. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3103683&form=6&db=m Cross talk between stimulatory and inhibitory guanosine 5'-triphosphate binding proteins: role in activation and desensitization of the adenylate cyclase response to vasopressin. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3104090&form=6&db=m A new GTP-binding protein in brain tissues serving as the specific substrate of islet-activating protein, pertussis toxin. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3104318&form=6&db=m Reactive sulfhydryl groups of alpha 39, a guanine nucleotide-binding protein from brain. Location and function. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3104320&form=6&db=m Presence of a functional inhibitory GTP-binding regulatory component, Gi, linked to adenylate cyclase in adipocytes of ob/ob mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3104325&form=6&db=m The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3106040&form=6&db=m Purification and immunochemical characterization of the major pertussis-toxin-sensitive guanine-nucleotide-binding protein of bovine-neutrophil membranes. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3106084&form=6&db=m Stimulus-response coupling in a cell-free platelet membrane system. GTP-dependent release of Ca2+ by thrombin, and inhibition by pertussis toxin and a monoclonal antibody that blocks calcium release by IP3. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3106786&form=6&db=m Immunological localization of the GTP-binding protein Go in different tissues of vertebrates and invertebrates. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3106961&form=6&db=m Deduced amino acid sequence of bovine retinal Go alpha: similarities to other guanine nucleotide-binding proteins. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3107454&form=6&db=m Signal transduction in insulin secretion: comparison between fuel stimuli and receptor agonists. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3107555&form=6&db=m Multiple isoforms of ADP-ribosylated G-like proteins from mammalian thyroid membranes. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3107559&form=6&db=m Phospholipase A2 activation in chemotactic peptide-stimulated HL60 granulocytes: synergism between diacylglycerol and Ca2+ in a protein kinase C-independent mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3108031&form=6&db=m Presence of three pertussis toxin substrates and Go alpha immunoreactivity in both plasma and granule membranes of chromaffin cells. causal interaction,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3108387&form=6&db=m Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3108444&form=6&db=m Chemoattractant-induced activation of c-fos gene expression in human monocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3108876&form=6&db=m Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3109254&form=6&db=m Mechanisms of lithium-vasopressin interaction in rabbit cortical collecting tubule. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3109499&form=6&db=m Guanine nucleotide regulation of the pertussis and cholera toxin substrates of rat glioma C6 BU1 cells. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3110146&form=6&db=m A new GTP-binding protein in differentiated human leukemic (HL-60) cells serving as the specific substrate of islet-activating protein, pertussis toxin. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3110156&form=6&db=m Identification of a new GTP-binding protein. A Mr = 43,000 substrate for pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3110164&form=6&db=m Glutaraldehyde inactivated pertussis vaccine: a less histamine sensitizing vaccine. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3111883&form=6&db=m Identification and purification of a novel G protein from neutrophils. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3112155&form=6&db=m Guanosine 5'-O-(3-thiotriphosphate) reduces ADP-ribosylation of the inhibitory guanine nucleotide-binding regulatory protein of adenylyl cyclase (Ni) by pertussis toxin without causing dissociation of the subunits of Ni. Evidence of existence of heterotrimeric pt+ and pt- conformations of Ni. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3113425&form=6&db=m Stimulations of arachidonate release and inositol-1,4,5-triphosphate formation are mediated by distinct G-proteins in human platelets. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3113428&form=6&db=m A pertussis/cholera toxin sensitive G-protein may mediate vasopressin-induced inositol phosphate formation in smooth muscle cell. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3113672&form=6&db=m Modification of opioid agonist binding by pertussis toxin. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3114162&form=6&db=m Ligand-receptor dynamics and signal amplification in the neutrophil. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3114250&form=6&db=m Physical and functional association of follitropin receptors with cholera toxin-sensitive guanine nucleotide-binding protein. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3114255&form=6&db=m A novel mechanism for the inhibition of adenylate cyclase via inhibitory GTP-binding proteins. Calmodulin-dependent inhibition of the cyclase catalyst by the beta gamma-subunits of GTP-binding proteins. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3115308&form=6&db=m Inhibition by pertussis toxin of fibroblast growth factor-stimulated hexose transport in Swiss 3T3 cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3115314&form=6&db=m Go, a major brain GTP binding protein in search of a function: purification, immunological and biochemical characteristics. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3115599&form=6&db=m Intracellular acidification, guanine-nucleotide binding proteins, and cytoskeletal actin. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3115621&form=6&db=m Positive vs. negative inotropic effects of carbachol in avian atrial muscle: role of Ni-like protein. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3115830&form=6&db=m G-proteins in Torpedo marmorata electric organ. Differential distribution in pre- and post-synaptic membranes and synaptic vesicles. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3115832&form=6&db=m Induction of c-fos proto-oncogene by a chemotactic peptide in human peripheral granulocytes. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3115980&form=6&db=m Phorbol ester-induced changes in cytoplasmic Ca2+ in human neutrophils. Involvement of a pertussis toxin-sensitive G protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3117058&form=6&db=m Dual role of GTP-binding proteins in the control of endothelial prostacyclin. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3117105&form=6&db=m Immunological and biochemical differentiation of guanyl nucleotide binding proteins: interaction of Go alpha with rhodopsin, anti-Go alpha polyclonal antibodies, and a monoclonal antibody against transducin alpha subunit and Gi alpha. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3117686&form=6&db=m Activities of complete and truncated forms of pertussis toxin subunits S1 and S2 synthesized by Escherichia coli. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3117789&form=6&db=m Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3117806&form=6&db=m Infection of L6E9 myoblasts with Trypanosoma cruzi alters adenylate cyclase activity and guanine nucleotide binding proteins. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3118869&form=6&db=m GTP-binding proteins in etiolated epicotyls of Pisum sativum (Alaska) seedlings. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3118991&form=6&db=m Platelet-activating factor both stimulates and "primes" human polymorphonuclear leukocyte actin filament assembly. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3119579&form=6&db=m Isolation of GTP-binding proteins from myeloid HL-60 cells. Identification of two pertussis toxin substrates. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3119717&form=6&db=m Molecular regulation of phagocyte function. Evidence for involvement of a guanosine triphosphate-binding protein in opsonin-mediated phagocytosis by monocytes. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3120696&form=6&db=m Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from Gs, Gi and Go. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3120720&form=6&db=m Differential sensitivity of arachidonic acid release and 1,2-diacylglycerol formation to pertussis toxin, GDP beta S and NaF in saponin-permeabilized human platelets: possible evidence for distinct GTP-binding proteins involving phospholipase C and A2 activation. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3120816&form=6&db=m Effects of insulin, pertussis toxin and cholera toxin on protein synthesis and diacylglycerol production in 3T3 fibroblasts: evidence for a G-protein mediated activation of phospholipase C in the insulin signal mechanism. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3121639&form=6&db=m Regulation of the affinity state of the N-formylated peptide receptor of neutrophils: role of guanine nucleotide-binding proteins and the cytoskeleton. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3122298&form=6&db=m Guanine nucleotide-binding proteins involved in transmembrane signaling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3122662&form=6&db=m G-protein distribution in canine cardiac sarcoplasmic reticulum and sarcolemma: comparison to rabbit skeletal muscle membranes and to brain and erythrocyte G-proteins. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3122742&form=6&db=m Modulation of tumor necrosis factor-alpha cytotoxicity in L929 cells by bacterial toxins, hydrocortisone and inhibitors of arachidonic acid metabolism. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3122750&form=6&db=m Pertussis and cholera toxin ADP-ribosylation in Dictyostelium discoideum membranes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3123009&form=6&db=m GTP-binding proteins Gi and Go transplanted onto Xenopus oocyte by rat brain messenger RNA. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3123090&form=6&db=m Role of a pertussis toxin-sensitive protein in the modulation of canine Purkinje fiber automaticity. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3123273&form=6&db=m Identification of novel GTP-binding proteins in the human neutrophil. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3123484&form=6&db=m Chromatographic resolution and immunologic identification of the alpha 40 and alpha 41 subunits of guanine nucleotide-binding regulatory proteins from bovine brain. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3123616&form=6&db=m Immunocytochemical localization of the guanine nucleotide-binding protein Go in primary cultures of neuronal and glial cells. causal interaction,diagnostic usage,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3123809&form=6&db=m The development of hemopoietic cells in response to stromal cells or growth factors is modified by agents that influence ADP-ribosylation. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3123934&form=6&db=m Pertussis toxin treatment results in tolerance to the depressant effects of opioid, monoaminergic, and muscarinic agonists on dorsal-horn network responses in mouse spinal cord-ganglion cultures. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3124764&form=6&db=m Inhibition of adenylate cyclase from luteinized rat ovary by monovalent cations: roles of the stimulatory guanine nucleotide-binding regulatory component and stimulatory hormone receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3124831&form=6&db=m Purification and some properties of GTP-binding proteins from pig heart plasma membranes. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3124929&form=6&db=m Intracellular GTP gamma S restores the ability of morphine to hyperpolarize rat locus coeruleus neurons after blockade by pertussis toxin. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3125065&form=6&db=m Adenylate cyclase activity of v-ras-k transformed rat epithelial thyroid cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3125164&form=6&db=m Physical and functional association of cytosolic inositolphospholipid-specific phospholipase C of calf thymocytes with a GTP-binding protein. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3126185&form=6&db=m G-protein-mediated epidermal growth factor signal transduction in a human breast cancer cell line. Evidence for two intracellular pathways distinguishable by pertussis toxin. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3126197&form=6&db=m Regulation of inositol phospholipid and inositol phosphate metabolism in chemoattractant-activated human polymorphonuclear leukocytes. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3126734&form=6&db=m GTP-binding proteins in a cyanobacterium Anabaena cylindrica. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3126798&form=6&db=m Reconstitution of the purified porcine atrial muscarinic acetylcholine receptor with purified porcine atrial inhibitory guanine nucleotide binding protein. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3127239&form=6&db=m Acetylcholine and cholecystokinin receptors functionally couple by different G-proteins to phospholipase C in pancreatic acinar cells. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3127241&form=6&db=m Identification of three pertussis toxin substrates (41, 40 and 39 kDa proteins) in mammalian brain. Comparison of predicted amino acid sequences from G-protein alpha-subunit genes and cDNAs with partial amino acid sequences from purified proteins. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3128172&form=6&db=m Stimulation of arachidonic acid release by guanine nucleotide in saponin-permeabilized neutrophils: evidence for involvement of GTP-binding protein in phospholipase A2 activation. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3128274&form=6&db=m Tumour necrosis factor (cachectin) induces phospholipase A2 activity and synthesis of a phospholipase A2-activating protein in endothelial cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3128340&form=6&db=m Nature and functioning of the pertussis toxin-sensitive G protein of neutrophils. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3128540&form=6&db=m Eukaryotic mono(ADP-ribosyl)transferase that ADP-ribosylates GTP-binding regulatory Gi protein. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3128727&form=6&db=m The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3129045&form=6&db=m Inhibition of interleukin 3 and colony-stimulating factor 1-stimulated marrow cell proliferation by pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3129188&form=6&db=m Identification of a guanine nucleotide-binding protein G(o) in human neuroblastoma. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3129426&form=6&db=m Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins). ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3129724&form=6&db=m Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3131145&form=6&db=m Major pertussis-toxin-sensitive GTP-binding protein of bovine lung. Purification, characterization and production of specific antibodies. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3132153&form=6&db=m Multiple species and isoforms of Bordetella pertussis toxin substrates. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3132155&form=6&db=m Coupling of TGF-beta-induced mitogenesis to G-protein activation in AKR-2B cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3132205&form=6&db=m Immunochemical and electrophoretic characterization of the major pertussis toxin substrate of the RAW264 macrophage cell line. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3132454&form=6&db=m The amino terminus of G protein alpha subunits is required for interaction with beta gamma. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3132531&form=6&db=m Possible involvement of pertussis toxin substrates (Gi, Go) in desipramine-induced refractoriness of adenylate cyclase in cerebral cortices of rats. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3132707&form=6&db=m Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3133193&form=6&db=m Regulation of the phosphoinositide pathway in cultured Sertoli cells from immature rats: effects of follicle-stimulating hormone and fluoride. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3133246&form=6&db=m Thiol reagents are substrates for the ADP-ribosyltransferase activity of pertussis toxin. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3133377&form=6&db=m Subcellular localization and quantitation of the major neutrophil pertussis toxin substrate, Gn. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3134019&form=6&db=m GTP-binding proteins and adenylate cyclase activity in v-Ki-ras transformed NIH/3T3 fibroblast cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3134023&form=6&db=m A novel site of action of a high affinity A1 adenosine receptor antagonist. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3134255&form=6&db=m Endogenous inhibitor of the ADP-ribosylation of (a) G-protein(s) as catalyzed by pertussis toxin is present in rat liver. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3134257&form=6&db=m Pertussis toxin-dependent and -independent hormonal effects on cultured renal epithelioid cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3134354&form=6&db=m Subcellular localization of Gi alpha in human neutrophils. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3135154&form=6&db=m Structural and functional relationships of guanosine triphosphate binding proteins. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3135265&form=6&db=m ADP-ribosyltransferase mutations in the catalytic S-1 subunit of pertussis toxin. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3135495&form=6&db=m GTP binding regulatory proteins of adenylate cyclase in Schistosoma mansoni at different stages of development. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3135838&form=6&db=m Cholera toxin and pertussis toxin substrates and endogenous ADP-ribosyltransferase activity in Drosophila melanogaster. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3136172&form=6&db=m A Drosophila melanogaster G protein alpha subunit gene is expressed primarily in embryos and pupae. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3137039&form=6&db=m Protective effect of acellular pertussis vaccines. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3137562&form=6&db=m Platelet cytosolic 44-kDa protein is a substrate of cholera toxin-induced ADP-ribosylation and is not recognized by antisera against the alpha subunit of the stimulatory guanine nucleotide-binding regulatory protein. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3137927&form=6&db=m Opioid peptides promote cholera-toxin-catalysed ADP-ribosylation of the inhibitory guanine-nucleotide-binding protein (Gi) in membranes of neuroblastoma x glioma hybrid cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3138970&form=6&db=m Platelet adenylate cyclase and phospholipase C are affected differentially by ADP-ribosylation. Effects on thrombin-mediated responses. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3138977&form=6&db=m Epidermal-growth-factor-induced formation of inositol phosphates in human A431 cells. Differences from the effect of bradykinin. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3138999&form=6&db=m Biochemical discrimination of the predominant pertussis toxin substrate of rabbit neutrophils from brain Gi and Go: isoelectric focusing improves resolution of pertussis toxin substrates. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3139031&form=6&db=m Guanosine 5'-triphosphate binding protein (Gi) and two additional pertussis toxin substrates associated with muscarinic receptors in rat heart myocytes: characterization and age dependency. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3139262&form=6&db=m Evidence for G protein mediation of serotonin- and GABAB-induced hyperpolarization of rat dorsal raphe neurons. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3139448&form=6&db=m GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3139455&form=6&db=m Adipocyte plasma membranes contain two Gi subtypes but are devoid of Go. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3139662&form=6&db=m Agonist-induced down-regulation of the angiotensin II receptor in primary cultures of rat hepatocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3139671&form=6&db=m Insulin inhibits pertussis toxin-catalyzed ADP-ribosylation of G-proteins. Evidence for a novel interaction between insulin receptors and G-proteins. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3139673&form=6&db=m Effects of low density lipoproteins and mevinolin on cholesterol content and muscarinic cholinergic responsiveness in cultured chick atrial cells. Regulation of levels of muscarinic receptors and guanine nucleotide regulatory proteins. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3139784&form=6&db=m Evidence for a GTP-binding protein involved in interferon-gamma transduction signal. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3139847&form=6&db=m Muscarine and t-LHRH suppress M-current by activating an IAP-insensitive G-protein. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3140790&form=6&db=m The inhibitory GTP-binding protein (Gi) occurs in rat Leydig cells and is differentially modified by lutropin and 12-O-tetradecanoylphorbol 13-acetate. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3140801&form=6&db=m GTP analogues promote release of the alpha subunit of the guanine nucleotide binding protein, Gi2, from membranes of rat glioma C6 BU1 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3140802&form=6&db=m G-proteins in skeletal muscle. Evidence for a 40 kDa pertussis-toxin substrate in purified transverse tubules. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3140813&form=6&db=m Different types of ADP-ribose protein bonds formed by botulinum C2 toxin, botulinum ADP-ribosyltransferase C3 and pertussis toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3141406&form=6&db=m Identification of a G protein in rough endoplasmic reticulum of canine pancreas. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3141412&form=6&db=m Purification and characterization of the 22,000-dalton GTP-binding protein substrate for ADP-ribosylation by botulinum toxin, G22K. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3141420&form=6&db=m Generation of inositol phosphates, cytosolic Ca2+, and ionic fluxes in PC12 cells treated with bradykinin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3141977&form=6&db=m Prostaglandins inhibit proliferation of the murine P815 mastocytoma by decreasing cytoplasmic free calcium levels [( Ca+2]i). causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3143408&form=6&db=m Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3143415&form=6&db=m Involvement of a pertussis toxin-sensitive G-protein-coupled phospholipase A2 in lipopolysaccharide-stimulated prostaglandin E2 synthesis in cultured rat mesangial cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3143599&form=6&db=m Guanine nucleotides inhibit poly-L-arginine-induced membrane damage in polymorphonuclear leukocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3143731&form=6&db=m Fluorescent labeling of signal-transducing G-proteins. Pertussis toxin-catalyzed etheno-ADP ribosylation of transducin. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3143813&form=6&db=m Evidence that guanosine triphosphate (GTP)-binding proteins control a synaptic response in brain: effect of pertussis toxin and GTP gamma S on the late inhibitory postsynaptic potential of hippocampal CA3 neurons. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3143845&form=6&db=m Developmental changes in the levels of substrates for cholera toxin-catalyzed and pertussis toxin-catalyzed ADP-ribosylation in rat cardiac cell membranes. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3144283&form=6&db=m Differential sensitivity of alpha o and alpha i to ADP-ribosylation by pertussis toxin in the intact cultured embryonic chick ventricular myocyte. Relationship to the role of G proteins in the coupling of muscarinic cholinergic receptors to inhibition of adenylate cyclase activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3145113&form=6&db=m G-proteins and egg activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3145208&form=6&db=m Role of G-proteins and adenylate cyclase in antinociception produced by intrathecal purines. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3145679&form=6&db=m Role of guanine nucleotide regulatory proteins and inositol phosphates in the hormone induced mobilization of hepatocyte calcium. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3145859&form=6&db=m Serum antibody response to filamentous hemagglutinin in patients with clinical pertussis measured by an enzyme-linked immunosorbent assay. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3152287&form=6&db=m An alpha 40 subunit of a GTP-binding protein immunologically related to Go mediates a dopamine-induced decrease of Ca2+ current in snail neurons. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3155263&form=6&db=m Adenosine diphosphate ribosylation of G proteins by pertussis and cholera toxin in isolated membranes. Different requirements for and effects of guanine nucleotides and Mg2+. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3155264&form=6&db=m Incubation of bovine thyroid slices with thyrotropin is associated with a decrease in the ability of pertussis toxin to adenosine diphosphate-ribosylate guanine nucleotide regulatory component(s). therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3157993&form=6&db=m Pertussis toxin inhibits fMet-Leu-Phe- but not phorbol ester-stimulated changes in rabbit neutrophils: role of G proteins in excitation response coupling. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3158374&form=6&db=m Effects of pertussis toxin on D2-dopamine receptor in rat striatum: evidence for coupling of Ni regulatory protein with D2-receptor. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3158403&form=6&db=m Break of unresponsiveness of delayed-type hypersensitivity to sheep red blood cells by pertussis toxin. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3162352&form=6&db=m Prostaglandin E2 is an inhibitor of adenylate cyclase in rabbit proximal tubule. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3165095&form=6&db=m Stimulation by tumor necrosis factor of HL-60 thymidine salvage pathway metabolism dissociated from proliferation. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3167939&form=6&db=m Inhibition of the effects of adenosine on force of contraction and the slow calcium inward current by pertussis toxin is associated with myocardial lesions. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3171686&form=6&db=m Voltage- and ligand-activated inwardly rectifying currents in dorsal raphe neurons in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3179368&form=6&db=m [Regulation by cations of adenylate cyclase activity in chicken tissues] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3181620&form=6&db=m Effect of the genetic background and specific mutation on adenylate cyclase activity in obesity syndromes. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3181621&form=6&db=m The regulation of adenylate cyclase in liver membranes of lean and obese mice. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3183431&form=6&db=m Toxin-neutralizing antibodies in patients with pertussis, as determined by an assay using Chinese hamster ovary cells. diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3183714&form=6&db=m Regulation of calcium homeostasis in sensory neurons by bradykinin. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3189529&form=6&db=m Adenosine receptor-mediated calcium mobilization in cortical collecting tubule cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3190695&form=6&db=m ADP-ribosylation of bovine S-antigen by cholera toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3192000&form=6&db=m Mechanical stimulation induces Ca2+i transients and membrane depolarization in cultured endothelial cells. Effects on Ca2+i in co-perfused smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3192520&form=6&db=m Mapping of the carboxyl terminus within the tertiary structure of transducin's alpha subunit using the heterobifunctional cross-linking reagent, 125I-N-(3-iodo-4-azidophenylpropionamido-S-(2-thiopyridyl) cysteine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3194420&form=6&db=m Anti-immunoglobulin pretreatment induces a calcium-mobilization response to the chemotactic agent N-formylmethionylleucylphenylalanine in Daudi lymphoblastoid cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3198661&form=6&db=m The effects of purified pertussis components and lipopolysaccharide on the results of the mouse weight gain test. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3202164&form=6&db=m Neuropeptide Y mobilizes Ca2+ and inhibits adenylate cyclase in human erythroleukemia cells. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3203744&form=6&db=m CCK and gastrin inhibit adenylate cyclase activity through a pertussis toxin-sensitive mechanism in the tumoral rat pancreatic acinar cell line AR 4-2J. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3204119&form=6&db=m Intracellular elevations of free calcium induced by activation of histamine H1 receptors in interphase and mitotic HeLa cells: hormone signal transduction is altered during mitosis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3211999&form=6&db=m Pertussis toxin inhibits the behavioural and ECoG effects induced by clonidine and yohimbine after their microinfusion into the locus coeruleus. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3215277&form=6&db=m Modulation of the accumulation of inositol phosphates and the mobilization of calcium in aortic myocytes. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3216897&form=6&db=m Dependence and cross-dependence in the guinea-pig myenteric plexus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3219476&form=6&db=m A 5-HT1-like receptor mediates a pertussis toxin-sensitive inhibition of rat ventromedial hypothalamic neurones in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3220110&form=6&db=m Pertussis toxin differentially reduces the efficacy of opioids to produce supraspinal analgesia in the mouse. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3223989&form=6&db=m ADP-ribosyl proteins formed by pertussis toxin are specifically cleaved by mercury ions. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3228495&form=6&db=m Delayed-type hypersensitivity responses in mice treated with pertussis toxin and betamethasone. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3234488&form=6&db=m Pertussis toxin inactivates the presynaptic serotonin autoreceptor in the hippocampus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3238002&form=6&db=m Pertussis toxin blocks an inhibition of hormone-stimulated glycogenolysis by prostaglandin E2 and its analogue in cultured hepatocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3241655&form=6&db=m Pertussis toxin attenuates clonidine inhibition of catecholamine release in adrenal chromaffin cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3241656&form=6&db=m Pertussis toxin pretreatment discriminates between pre- and postsynaptic actions of baclofen in rat dorsal raphe nucleus in vitro. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3244401&form=6&db=m P2-purinoceptor induced prostaglandin synthesis in primary rat astrocyte cultures. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3259133&form=6&db=m Bradykinin induces the bi-phasic production of lysophosphatidyl inositol and diacylglycerol in a dorsal root ganglion X neurotumor hybrid cell line, F-11. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3259580&form=6&db=m Acellular pertussis vaccines: evaluation of reversion in a nude mouse model. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3262738&form=6&db=m Carbachol depolarizes and accelerates pacemaker activity in the sinoatrial node of chicks treated with pertussis toxin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3263485&form=6&db=m Clinical, metabolic, and antibody responses of adult volunteers to an investigational vaccine composed of pertussis toxin inactivated by hydrogen peroxide. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3263806&form=6&db=m PTH elevates inositol polyphosphates and diacylglycerol in a rat osteoblast-like cell line. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3273462&form=6&db=m A sensitive chemiluminescence assay for pertussis toxin and for evaluation of cell-free pertussis toxoids. diagnostic usage,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3273618&form=6&db=m Overview of currently available Japanese acellular pertussis vaccines and future problems. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3281387&form=6&db=m Trial of a new acellular pertussis vaccine in healthy adult volunteers. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3282920&form=6&db=m Pertussis toxin reverses the inhibition of insulin secretion caused by [Arg8]vasopressin in rat pancreatic islets. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3283118&form=6&db=m Angiotensin II and guanine nucleotides stimulate formation of inositol 1,4,5-trisphosphate and its metabolites in permeabilized adrenal glomerulosa cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3283121&form=6&db=m Pertussis toxin treatment attenuates some effects of insulin in BC3H-1 murine myocytes. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3285995&form=6&db=m Invasiveness in hepatocyte and fibroblast monolayers and metastatic potential of T-cell hybridomas in mice. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3287141&form=6&db=m Peptide mapping studies of the pertussis toxin substrate in human neutrophils, platelets and erythrocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3290256&form=6&db=m Impaired cardiac muscarinic receptor function in dogs with heart failure. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3291867&form=6&db=m Insulin-like growth factors stimulate chemotaxis in human melanoma cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3308515&form=6&db=m Pertussis toxin does not affect the time course of exocytosis in mast cells stimulated by intracellular application of GTP-gamma-S. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3309858&form=6&db=m Murine responses to immunization with pertussis toxin and bovine serum albumin: I. Mortality observed after bovine albumin challenge is due to an anaphylactic reaction. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3316207&form=6&db=m Characterization of transducin from bovine retinal rod outer segments. Participation of the amino-terminal region of T alpha in subunit interaction. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3320046&form=6&db=m Structural characterization of pertussis toxin A subunit. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3322408&form=6&db=m Ca2+-stimulated catecholamine release from alpha-toxin-permeabilized PC12 cells: biochemical evidence for exocytosis and its modulation by protein kinase C and G proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3323602&form=6&db=m Captopril inhibits the hydroosmotic effect of ADH in the cortical collecting tubule. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3324692&form=6&db=m Electrophysiologic responses and adenylate cyclase activities of mouse spinal cord-dorsal root ganglion explants rendered tolerant by chronic exposure to morphine or pertussis toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3342050&form=6&db=m Pertussis toxin inhibits angiotensin II-mediated phosphatidylinositol breakdown and ADP-ribosylates a 40 Kd protein in cultured smooth muscle cells. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3348812&form=6&db=m Chemotactic factor induced tyrosine phosphorylation of membrane associated proteins in rabbit peritoneal neutrophils. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3348814&form=6&db=m Intracellular calcium rise produced by platelet-activating factor is deactivated by fMet-Leu-Phe and this requires uninterrupted activation sequence: role of protein kinase C. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3350059&form=6&db=m Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3350815&form=6&db=m Lectin-like binding of pertussis toxin to a 165-kilodalton Chinese hamster ovary cell glycoprotein. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3350860&form=6&db=m Direct effects of wheat germ agglutinin on inositol phosphate formation and cytosolic-free calcium level in intestine 407 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3351377&form=6&db=m Relationship between membrane depolarization and extracellular calcium influx during neutrophil activation. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3351428&form=6&db=m Modification by pertussis toxin of the responses of bovine anterior pituitary cells to acetylcholine and dopamine: effects on hormone secretion and 86Rb efflux. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3357484&form=6&db=m Interaction of [3H]spiperone with rat striatal dopamine D-2 receptors: kinetic evidence for antagonist-induced formation of ternary complex. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3358757&form=6&db=m Neutrophil activation by surface bound IgG: pertussis toxin insensitive activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3359581&form=6&db=m Pertussis toxin-treated dog: a whole animal model of impaired inhibitory regulation of adenylate cyclase. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3370465&form=6&db=m Modulation of adenylate cyclase activity of mouse spinal cord-ganglion explants by opioids, serotonin and pertussis toxin. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3370534&form=6&db=m Bradykinin stimulates a rise in cytosolic calcium in renal glomerular mesangial cells via a pertussis toxin insensitive pathway. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3383778&form=6&db=m Modulation of prolactin-stimulated Nb2 lymphoma cell mitogenesis by cholera toxin and pertussis toxin. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3384473&form=6&db=m Dermonecrotic toxin and tracheal cytotoxin, putative virulence factors of Bordetella avium. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3390705&form=6&db=m Muscarinic receptor-mediated hydrolysis of phosphatidylinositols in human neuroblastoma (SH-SY5Y) cells is sensitive to pertussis toxin. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3390898&form=6&db=m Effect of elastin peptides and N-formyl-methionyl-leucyl phenylalanine on cytosolic free calcium in polymorphonuclear leukocytes of healthy middle-aged and elderly subjects. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3391283&form=6&db=m Pertussis toxin stimulates delayed-onset, Ca2+-dependent catecholamine release and the ADP-ribosylation of a 40 kDa protein in bovine adrenal chromaffin cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3392052&form=6&db=m Differential effects of pertussis toxin on muscarinic responses in isolated atria and smooth muscle. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3392497&form=6&db=m Pertussis toxin-catalysed ADP-ribosylation of endometrial proteins in sheep. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3396155&form=6&db=m Muscarinic cholinergic-receptor stimulation of specific GTP hydrolysis related to adenylate cyclase activity in canine cardiac sarcolemma. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3401234&form=6&db=m Role of dopamine and indolamine derivatives in the regulation of the sea urchin adenylate cyclase. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3401707&form=6&db=m Norepinephrine, acting via adenylate cyclase, inhibits melatonin output but does not phase-shift the pacemaker in cultured chick pineal cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3401779&form=6&db=m Two mechanisms of photoendocrine transduction in cultured chick pineal cells: pertussis toxin blocks the acute but not the phase-shifting effects of light on the melatonin rhythm. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3412640&form=6&db=m Pertussis toxin suppresses long-term potentiation of hippocampal mossy fiber synapses. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3420947&form=6&db=m Cytoskeletal alterations as a parameter for assessment of toxicity. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3421921&form=6&db=m Recruitment of actin to the cytoskeletons of human monocyte-like cells activated by complement fragment C5a. Is protein kinase C involved? causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3425721&form=6&db=m Prostaglandins and the urinary concentrating defect in potassium-depleted rabbits. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3426878&form=6&db=m The role of pertussis toxin and betamethasone on lymphocyte accumulation in the lungs of mice. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3426879&form=6&db=m Antibody levels to pertussis toxin in preschool children in a non-vaccinating country (Sweden). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3435474&form=6&db=m Hydrodynamic properties of adenosine Ri receptors solubilized from rat cerebral-cortical membranes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3435505&form=6&db=m The action of pertussis toxin on heart adenylate cyclase and lipolysis in the parametrial adipose tissue of the rat. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3435835&form=6&db=m Pertussis toxin blocks the inhibitory effect of adenosine on rat cerebral cortical neurons. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3443977&form=6&db=m Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3458250&form=6&db=m Synergy between phorbol esters, 1-oleyl-2-acetylglycerol, urushiol, and calcium ionophore in eliciting aggregation of marine sponge cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3461464&form=6&db=m Treatment of human platelets with trypsin, thrombin, or collagen inhibits the pertussis toxin-induced ADP-ribosylation of a 41-kDa protein. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3464278&form=6&db=m Features of the translocation of protein kinase C in neutrophils stimulated with the chemotactic peptide f-Met-Leu-Phe. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3465038&form=6&db=m Pertussis toxin-sensitive pathway in the stimulation of c-myc expression and DNA synthesis by bombesin. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3466805&form=6&db=m Detection of the major pertussis toxin substrate of human leukocytes with antisera raised against synthetic peptides. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3477571&form=6&db=m Stimulation by leukotriene D4 of increases in the cytosolic concentration of calcium in dimethylsulfoxide-differentiated HL-60 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3486070&form=6&db=m The effects of pertussis toxin on the induction and transfer of experimental autoimmune uveoretinitis. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3488233&form=6&db=m Pertussis toxin blocks angiotensin II-induced calcium influx but not inositol trisphosphate production in adrenal glomerulosa cell. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3489712&form=6&db=m The role of cytosolic free calcium in the generation of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in HL-60 cells. Differential effects of chemotactic peptide receptor stimulation at distinct Ca2+ levels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3492493&form=6&db=m The effects of phorbol myristate acetate and chemotactic peptide on transmembrane potentials and cytosolic free calcium in mature granulocytes evolve sequentially as the cells differentiate. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3494077&form=6&db=m Augmentation of the antibody response by antigen-specific glycosylation-enhancing factor. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3494104&form=6&db=m Modulation of bradykinin-induced inositol trisphosphate release in a novel neuroblastoma x dorsal root ganglion sensory neuron cell line (F-11). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3495499&form=6&db=m Characterization of PHA and anti-T3 induced transduction mechanisms in a human T-cell leukaemia line. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3496269&form=6&db=m Cap formation in a B-lymphocyte cell line is inhibited by pertussis toxin and phorbol ester. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3496885&form=6&db=m Pertussis toxin inhibits stimulated motility independently of the adenylate cyclase pathway in human melanoma cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3496971&form=6&db=m Studies on primed precursors of effector T cells involved in delayed-type hypersensitivity to sheep red blood cells in mice. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3498569&form=6&db=m The primary and secondary cellular immune responses to whole cell Bordetella pertussis vaccine and its components. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3499903&form=6&db=m Pertussis toxin inhibits the action of insulin-like growth factor-I. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3500168&form=6&db=m Inhibition of parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by transforming growth factor alpha and epidermal growth factor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3500949&form=6&db=m Epidermal growth factor and angiotensin II stimulate formation of inositol 1,4,5- and inositol 1,3,4-trisphosphate in hepatocytes. Differential inhibition by pertussis toxin and phorbol 12-myristate 13-acetate. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3501716&form=6&db=m Evidence that a pertussis-toxin-sensitive substrate is involved in the stimulation by epidermal growth factor and vasopressin of plasma-membrane Ca2+ inflow in hepatocytes. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3502344&form=6&db=m ATP-induced calcium transient in cultured rat aortic smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3503504&form=6&db=m Influences of pertussis toxin, guanine nucleotides and forskolin on adenylate cyclase in striatal membranes of infant, adult and senescent rats. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3503532&form=6&db=m Enhancement of parathyroid hormone-responsive renal cortical adenylate cyclase activity by a cytosol protein activator from rat reticulocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3525228&form=6&db=m Protein-chemical analysis of pertussis toxin reveals homology between the subunits S2 and S3, between S1 and the A chains of enterotoxins of Vibrio cholerae and Escherichia coli and identifies S2 as the haptoglobin-binding subunit. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3529763&form=6&db=m [Purification and properties of Bordetella pertussis toxin] diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3535903&form=6&db=m Guanine nucleotides reduce the free calcium requirement for secretion of granule constituents from permeabilized human neutrophils. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3537692&form=6&db=m Antibodies to the ras gene product inhibit adenylate cyclase and accelerate progesterone-induced cell division in Xenopus laevis oocytes. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3539804&form=6&db=m Role of the A subunit of pertussis toxin in alteration of Chinese hamster ovary cell morphology. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3541466&form=6&db=m [Hybridomas synthesizing monoclonal antibodies to Bordetella pertussis toxins] ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3541923&form=6&db=m Guanine nucleotide regulation of phospholipase C activity in permeabilized rabbit neutrophils. Inhibition by pertussis toxin and sensitization to submicromolar calcium concentrations. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3545389&form=6&db=m Pertussis toxin blocks depressant effects of opioid, monoaminergic and muscarinic agonists on dorsal-horn network responses in spinal cord-ganglion cultures. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3546569&form=6&db=m Hypoglycaemia and acute stress-induced hyperinsulinaemia in mice infected with Bordetella pertussis or treated with pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3548437&form=6&db=m Neuropeptide Y inhibits renin release by a pertussis toxin-sensitive mechanism. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3549397&form=6&db=m Preliminary data from a clinical trial (phase 2) of an acellular pertussis vaccine, J-NIH-6. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3549567&form=6&db=m Expression and immunological properties of the five subunits of pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3558828&form=6&db=m Solid phase enzyme immunoassays of pertussis toxin using peroxidase or biotin labelled antibodies. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3561385&form=6&db=m Effects of histamine on the metabolism of isolated rat hepatocytes: roles of H1- and H2-histamine receptors. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3570457&form=6&db=m Immune response to the B oligomer of pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3571570&form=6&db=m Pertussis toxin blocks melatonin-induced pigment aggregation in Xenopus dermal melanophores. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3579947&form=6&db=m Pertussis toxin facilitates secretagogue-induced catecholamine release from cultured bovine adrenal chromaffin cells. causal interaction,ongoing research,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3584073&form=6&db=m Bordetella parapertussis and Bordetella bronchiseptica contain transcriptionally silent pertussis toxin genes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3594083&form=6&db=m Differential effects of pertussis toxin and lithium on muscarinic responses in the atria and ileum: evidence for receptor heterogeneity. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3594245&form=6&db=m Serotonin decreases population spike amplitude in hippocampal cells through a pertussis toxin substrate. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3629615&form=6&db=m Pertussis toxin induces fatty liver, hyperlipemia and ketosis in hamsters. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3630484&form=6&db=m [Trial of pertussis toxin activity in vitro on CHO cells] diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3652046&form=6&db=m Inhibition of lymphoma invasion and liver metastasis formation by pertussis toxin. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3653036&form=6&db=m Decreased potency of glucagon on transformed-induced MDCK cells does not reflect an alteration of adenylate cyclase components. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3663107&form=6&db=m Inositol phosphate metabolism in bradykinin-stimulated human A431 carcinoma cells. Relationship to calcium signalling. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3666035&form=6&db=m Pertussis toxin reduces the antiadrenergic effect of 2-chloroadenosine on papillary muscle and the direct negative inotropic effect of 2-chloroadenosine on atrium. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3667609&form=6&db=m Pertussis toxin can activate human platelets. Comparative effects of holotoxin and its ADP-ribosylating S1 subunit. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3673208&form=6&db=m Synergistic teratogenic effect produced in mice by whole cell pertussis vaccine. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3680221&form=6&db=m Adenosine receptor down-regulation and insulin resistance following prolonged incubation of adipocytes with an A1 adenosine receptor agonist. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3680302&form=6&db=m The activity of purified Bordetella pertussis components in murine encephalopathy. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3684502&form=6&db=m Actions of angiotensin II and noradrenaline on smooth muscle cells of the canine mesenteric artery. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3697768&form=6&db=m Pertussis toxin blocks the outward currents evoked by opiate and alpha 2-agonists in locus coeruleus neurons. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3699167&form=6&db=m A step sensitive to pertussis toxin and phorbol ester in human neutrophils regulates chemotaxis and capping but not phagocytosis. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3704651&form=6&db=m Pertussis toxin gene: nucleotide sequence and genetic organization. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3711124&form=6&db=m Immunochemical evidence for a novel pertussis toxin substrate in human neutrophils. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3732193&form=6&db=m Pertussis toxin mediates ADP-ribosylation of pituitary membrane proteins. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3732384&form=6&db=m Pertussis toxin inhibits the antinociceptive action of morphine in the rat. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3736338&form=6&db=m Effect of pertussis toxin on the heart muscarinic-cholinergic receptors and their function. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3736664&form=6&db=m Botulinum C2 toxin ADP-ribosylates actin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3758177&form=6&db=m Effect of pertussis toxin on the heart acetylcholine muscarinic receptor affinity. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3771575&form=6&db=m Bradykinin stimulation of inositol polyphosphate production in porcine aortic endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3777181&form=6&db=m Dual regulation of PTH-stimulated adenylate cyclase activity by GTP. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3778661&form=6&db=m Characterization of lithium-induced enzyme release from human polymorphonuclear leukocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3782096&form=6&db=m Cytochalasin B enhancement of the diacylglycerol response in formyl peptide-stimulated neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3783338&form=6&db=m Adverse reactions and antibody responses to acellular pertussis vaccine. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3800944&form=6&db=m Effect of adenosine deaminase, N6-phenylisopropyladenosine and hypothyroidism on the responsiveness of rat brown adipocytes to noradrenaline. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3800973&form=6&db=m Guanine nucleotide-dependent pertussis-toxin-insensitive stimulation of inositol phosphate formation by carbachol in a membrane preparation from human astrocytoma cells. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3803594&form=6&db=m NADP efficiently inhibits endogenous but not pertussis toxin-catalyzed covalent modification of membrane proteins incubated with NAD. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3805010&form=6&db=m Heterologous desensitization of the inhibitory A1 adenosine receptor-adenylate cyclase system in rat adipocytes. Regulation of both Ns and Ni. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3816821&form=6&db=m The role of the cytosolic free Ca2+ transient for fMet-Leu-Phe induced actin polymerization in human neutrophils. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3818081&form=6&db=m Nucleotide sequence homology to pertussis toxin gene in Bordetella bronchiseptica and Bordetella parapertussis. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3818604&form=6&db=m Reconstitution of muscarinic cholinergic inhibition of adenylate cyclase activity in homogenates of embryonic chick hearts by membranes of adult chick hearts. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3821934&form=6&db=m Effects of sodium and GTP on the binding kinetics of [3H]diprenorphine in NG 108-15 cell membranes. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3826625&form=6&db=m Rapid purification of Bordetella pertussis toxin by alternating affinity and hydrophobic chromatography. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3827824&form=6&db=m Further evidence for the involvement of a phosphoprotein in the respiratory burst oxidase of human neutrophils. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3831404&form=6&db=m [Increase of intradermal vascular permeability by pertussis toxin] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3835079&form=6&db=m Anti-pertussis toxin IgG and anti-filamentous hemagglutinin IgG production in children immunized with pertussis acellular vaccine and comparison of these titers with the sera of pertussis convalescent children. diagnostic usage,ongoing research,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3847338&form=6&db=m Toxins which activate adenylate cyclase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3856323&form=6&db=m Sequence of the alpha subunit of photoreceptor G protein: homologies between transducin, ras, and elongation factors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3857605&form=6&db=m Pertussis toxin inhibition of chemotaxis and the ADP-ribosylation of a membrane protein in a human-mouse hybrid cell line. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3862711&form=6&db=m Correlation between keratinocyte expression of Ia and the intensity and duration of contact hypersensitivity responses in mice. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3863817&form=6&db=m ADP-ribosylation of transducin by pertussis toxin. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3863818&form=6&db=m Pertussis toxin-catalyzed ADP-ribosylation of transducin. Cysteine 347 is the ADP-ribose acceptor site. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3877077&form=6&db=m Chemotactic peptide activation of human neutrophils and HL-60 cells. Pertussis toxin reveals correlation between inositol trisphosphate generation, calcium ion transients, and cellular activation. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3894036&form=6&db=m Pertussis toxin potentiates anesthesia-induced renin secretion. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3899183&form=6&db=m Stimulation and inhibition of rat basophilic leukemia cell adenylate cyclase by forskolin. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3907810&form=6&db=m Action of insulin modulated by pertussis toxin in rat adipocytes. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3914965&form=6&db=m Effect of proteolytic enzymes, storage and reduction on the structure and biological activity of pertussigen, a toxin from Bordetella pertussis. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3918851&form=6&db=m The membrane-bound spermatozoal adenylyl cyclase system does not share coupling characteristics with somatic cell adenylyl cyclases. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3919730&form=6&db=m Pertussis toxin treatment modifies opiate action in the rat brain striatum. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3922367&form=6&db=m Heart contains two substrates (Mr = 40,000 and 41,000) for pertussis toxin-catalyzed ADP-ribosylation that co-purify with Ns. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3922971&form=6&db=m Absence of the inhibitory effect of guanine nucleotides on adenylate cyclase activity in white adipocyte membranes of the ob/ob mouse. Effect of the ob gene. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3922980&form=6&db=m Coupling of the guanine nucleotide regulatory protein to chemotactic peptide receptors in neutrophil membranes and its uncoupling by islet-activating protein, pertussis toxin. A possible role of the toxin substrate in Ca2+-mobilizing receptor-mediated signal transduction. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3923487&form=6&db=m Antibodies against the carboxyl-terminal 5-kDa peptide of the alpha subunit of transducin crossreact with the 40-kDa but not the 39-kDa guanine nucleotide binding protein from brain. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3924580&form=6&db=m Reticulocyte cytosol activator protein: effects on the stimulatory and inhibitory regulatory proteins of adenylate cyclase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3924834&form=6&db=m Immune suppression and induction of gamma interferon by pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3928090&form=6&db=m Induction of muscarinic cholinergic responsiveness in Xenopus oocytes by mRNA isolated from rat brain. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3928624&form=6&db=m Physical and immunological characterization of a guanine nucleotide-binding protein purified from bovine cerebral cortex. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3929781&form=6&db=m Pertussis toxin inhibits intracellular pH changes in human neutrophils stimulated by N-formyl-methionyl-leucyl-phenylalanine. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3930663&form=6&db=m Involvement of both inhibitory and stimulatory guanine nucleotide binding proteins in the expression of chronic opiate regulation of adenylate cyclase activity in NG108-15 cells. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3932445&form=6&db=m The stimulatory and inhibitory guanine nucleotide-binding proteins of adenylate cyclase in erythrocytes from patients with pseudohypoparathyroidism type I. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3933489&form=6&db=m The interactions between the activatory guanine nucleotide binding protein and the catalytic subunit of adenylate cyclase in rat liver plasma membranes. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3934013&form=6&db=m Pertussis toxin attenuates angiotensin II-induced vasoconstriction and inhibition of renin release. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3934172&form=6&db=m Amino acid-specific ADP-ribosylation. Sensitivity to hydroxylamine of [cysteine(ADP-ribose)]protein and [arginine(ADP-ribose)]protein linkages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3936483&form=6&db=m Pertussis toxin substrate is a guanosine 5'-[beta-thio]diphosphate-, N-ethylmaleimide-, Mg2+- and temperature-sensitive GTP-binding protein. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3938969&form=6&db=m Pertussis toxin-catalyzed ADP-ribosylation of adenylate cyclase. Effects of guanyl nucleotides and rhodopsin. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3940899&form=6&db=m Hydrophobic photolabelling of pertussis toxin subunits interacting with lipids. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3941589&form=6&db=m Effect of pertussis toxin on water metabolism in the rat. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3957908&form=6&db=m D-2 dopamine receptor-mediated inhibition of pro-opiomelanocortin synthesis in rat intermediate lobe. Abolition by pertussis toxin or activators of adenylate cyclase. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3960397&form=6&db=m Evidence for the inhibitory subunit of adenylate cyclase (Ni) in nervous and heart tissue of Aplysia. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3964680&form=6&db=m Structure-function relationship of islet-activating protein, pertussis toxin: biological activities of hybrid toxins reconstituted from native and methylated subunits. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4038602&form=6&db=m Attenuation of chick heart adenylate cyclase by muscarinic receptors after pertussis toxin treatment. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4038988&form=6&db=m Site-selective homing of antigen-primed lymphocyte populations can play a crucial role in the efferent limb of cell-mediated immune responses in vivo. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4039324&form=6&db=m The standardization of an assay for pertussis toxin and antitoxin in microplate culture of Chinese hamster ovary cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4039870&form=6&db=m Comparative biological activities of whole cell pertussis vaccine and a new acellular preparation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4058421&form=6&db=m Agonist interactions with cardiac muscarinic receptors. Effects of Mg2+, guanine nucleotides, and monovalent cations. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4058598&form=6&db=m Opioid dependence prevents the action of pertussis toxin in the guinea-pig myenteric plexus. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4298089&form=6&db=m [Cytomorphological and enzymocytochemical studies of tissue cultures treated with pertussis toxin] ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4304114&form=6&db=m [Study on pertussis using nerve tissue culture. 2. Study on the influence of pertussis toxin on cultured nerve elements] ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6086280&form=6&db=m "Antigonadal" activity of the neurohypophysial hormones in cultured rat testicular cells: abolition by pertussis toxin. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6086320&form=6&db=m Spontaneous phase variation in Bordetella pertussis is a multistep non-random process. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6086607&form=6&db=m Altered activity of the inhibitory guanyl nucleotide-binding component (Ni) induced by pertussis toxin. Uncoupling of Ni from receptor with continued coupling of Ni to the catalytic unit. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6088647&form=6&db=m Pertussis toxin and extracytoplasmic adenylate cyclase as virulence factors of Bordetella pertussis. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6088743&form=6&db=m [Demonstration of the immunostimulating component(s) in Bordetella pertussis (Phase I, strain Tohama), other than cell wall peptidoglycan, endotoxic lipopolysaccharide and pertussis toxin] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6090844&form=6&db=m Effect of pertussis toxin on the adrenergic regulation of plasma renin activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6091103&form=6&db=m Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6091647&form=6&db=m Sodium regulation of opioid agonist binding is potentiated by pertussis toxin. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6093069&form=6&db=m The concept of pertussis as a toxin-mediated disease. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6093766&form=6&db=m Pertussis toxin blocks the inhibitory effect of muscarinic cholinergic agonists on cyclic AMP accumulation and prolactin secretion in GH3 anterior-pituitary tumour cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6093808&form=6&db=m Pertussis toxin inhibits the rise in the intracellular concentration of free calcium that is induced by chemotactic factors in rabbit neutrophils: possible role of the "G proteins" in calcium mobilization. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6094010&form=6&db=m Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6094351&form=6&db=m Monoclonal antibody against pertussis toxin: effect on toxin activity and pertussis infections. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6096373&form=6&db=m Conversion of adrenergic mechanism from an alpha- to a beta-type during primary culture of rat hepatocytes. Accompanying decreases in the function of the inhibitory guanine nucleotide regulatory component of adenylate cyclase identified as the substrate of islet-activating protein. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6097215&form=6&db=m Effects of pertussis toxin on adenylate cyclase responses to prostaglandin E2 and calcitonin in human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6098260&form=6&db=m Further contributions to an improved pertussis vaccine: I. Molecular mechanisms of pertussis toxin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6130091&form=6&db=m Pertussis toxin inhibits enkephalin stimulation of GTPase of NG108-15 cells. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6133780&form=6&db=m Islet-activating protein prevents nicotinic acid-induced GTPase stimulation and GTP but not GTP gamma S-induced adenylate cyclase inhibition in rat adipocytes. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6134612&form=6&db=m Pertussis toxin blocks the somatostatin-induced inhibition of growth hormone release and adenosine 3',5'-monophosphate accumulation. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6138037&form=6&db=m Pertussis toxin blocks somatostatin's inhibition of stimulated cyclic AMP accumulation in anterior pituitary tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6140011&form=6&db=m Suppression of passive cutaneous anaphylaxis by pertussis toxin, an islet-activating protein, as a result of inhibition of histamine release from mast cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6140642&form=6&db=m Islet-activating protein impairs alpha 2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6141165&form=6&db=m Inhibition of bovine rod outer segment GTPase by Bordetella pertussis toxin. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6141934&form=6&db=m Human pancreatic tumor growth hormone (GH) - releasing factor and cyclic adenosine 3',5'- monophosphate evoke GH release from anterior pituitary cells: the effects of pertussis toxin, cholera toxin, forskolin, and cycloheximide. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6142822&form=6&db=m Mechanism of pertussis toxin action on the adenylate cyclase system. Inhibition of the turn-on reaction of the inhibitory regulatory site. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6142883&form=6&db=m ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6145319&form=6&db=m Pertussis toxin: lessons from biological and biochemical effects in different cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6146090&form=6&db=m Insulin secretion and action. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6150041&form=6&db=m Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6151992&form=6&db=m Pertussis toxin-catalyzed ADP-ribosylation: effects on the coupling of inhibitory receptors to the adenylate cyclase system. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6195660&form=6&db=m Promotion of lipolysis in rat adipocytes by pertussis toxin: reversal of endogenous inhibition. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6199389&form=6&db=m Pertussis toxin actions on the pituitary-derived 235-1 clone: effects of PGE1, cholera toxin, and forskolin on cyclic AMP metabolism and prolactin release. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6203340&form=6&db=m Islet-activating protein, pertussis toxin: a specific uncoupler of receptor-mediated inhibition of adenylate cyclase. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6204890&form=6&db=m Islet-activating protein, pertussis toxin, inhibits Ca2+-induced and guanine nucleotide-dependent releases of histamine and arachidonic acid from rat mast cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6206001&form=6&db=m Activation of distinct T cell subsets involved in IgM antibody response of mice by pertussis toxin from Bordetella pertussis strain Maeno. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6207108&form=6&db=m Interaction of monoclonal antibodies with pertussis toxin and its subunits. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6209272&form=6&db=m ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. A possible role of the toxin substrate in Ca2+-mobilizing biosignaling. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6225433&form=6&db=m Selective decrease in the affinity of D2 dopamine receptor for agonist induced by islet-activating protein, pertussis toxin, associated with ADP-ribosylation of the specific membrane protein of bovine striatum. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6290206&form=6&db=m Stimulatory effect of pertussis toxin on tissue cyclic AMP levels in canine thyroid slices. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6293544&form=6&db=m Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6298231&form=6&db=m Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6300102&form=6&db=m Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6300694&form=6&db=m Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6301374&form=6&db=m Guanine nucleotide activation and inhibition of adenylate cyclase as modified by islet-activating protein, pertussis toxin, in mouse 3T3 fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 1,1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6305846&form=6&db=m Novel biological property of pertussis toxin: chemotactic activity on human monocytes. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6308612&form=6&db=m Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6309562&form=6&db=m Effect of pertussis toxin on hormonal responsiveness of rat hepatocytes. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6309661&form=6&db=m Effect of heptakis (2,6-O-dimethyl) beta-cyclodextrin on the production of pertussis toxin by Bordetella pertussis. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6310432&form=6&db=m Luteinizing hormone secretion is enhanced by pertussis toxin, cholera toxin, and forskolin. Evidence for the involvement of the cyclic AMP-generating system. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6311749&form=6&db=m Tn5-induced mutations affecting virulence factors of Bordetella pertussis. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6311827&form=6&db=m Activation by thiol of the latent NAD glycohydrolase and ADP-ribosyltransferase activities of Bordetella pertussis toxin (islet-activating protein). ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6313062&form=6&db=m Effect of pertussis toxin on the hormonal regulation of cyclic AMP levels in hamster fat cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6315242&form=6&db=m Effects of pertussis toxin on delayed-type hypersensitivity responses and on the activity of suppressor T cells on the responses. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6315733&form=6&db=m Pertussis toxin. Affinity purification of a new ADP-ribosyltransferase. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6316958&form=6&db=m Selective regulation by pertussis toxin of insulin-induced activation of particulate cAMP phosphodiesterase activity in 3T3-L1 adipocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6319376&form=6&db=m ADP-ribosylation of adenylate cyclase by pertussis toxin. Effects on inhibitory agonist binding. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6319385&form=6&db=m [3H]GDP release from rat and hamster adipocyte membranes independently linked to receptors involved in activation or inhibition of adenylate cyclase. Differential susceptibility to two bacterial toxins. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6319845&form=6&db=m "Pertussis toxin induces tachycardia and impairs the increase in blood pressure produced by alpha 2-adrenergic agonists". unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6319865&form=6&db=m Pertussis toxin decreases opiate receptor binding and adenylate inhibition in a neuroblastoma x glioma hybrid cell line. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6320661&form=6&db=m LH release is facilitated by agents that alter cyclic AMP-generating system. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6324776&form=6&db=m Requirement for both choleragen and pertussis toxin to obtain maximal activation of adenylate cyclase in cultured cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6324881&form=6&db=m Activation of lipolysis and cyclic AMP accumulation in rabbit adipocytes by isoproterenol in the presence of forskolin or pertussis toxin. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6325127&form=6&db=m Predominance of alpha 2-adrenoceptors in porcine thyroid: biochemical and pharmacological correlations. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6327179&form=6&db=m Transducin and the cyclic GMP phosphodiesterase: amplifier proteins in vision. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6327335&form=6&db=m Direct action of pertussis toxin in isolated hamster fat cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6329826&form=6&db=m Effect of pertussis toxin on alpha 2-adrenoceptors: decreased formation of the high-affinity state for agonists. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6330097&form=6&db=m Differential effect of pertussis toxin on the affinity state for agonists of renal alpha 1- and alpha 2- adrenoceptors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6343381&form=6&db=m A role of the B-oligomer moiety of islet-activating protein, pertussis toxin, in development of the biological effects on intact cells. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6350297&form=6&db=m Effects of pertussis toxin treatment on the metabolism of rat adipocytes. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6353019&form=6&db=m Species differences in actions of islet-activating protein, pertussis toxin. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6365589&form=6&db=m Effects of islet-activating protein on insulin- and isoprenaline-stimulated glucose transport in isolated rat adipocytes. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6383483&form=6&db=m Dual mechanisms involved in development of diverse biological activities of islet-activating protein, pertussis toxin, as revealed by chemical modification of lysine residues in the toxin molecule. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6386524&form=6&db=m Pertussis toxin catalyzes the ADP-ribosylation of two distinct peptides, 40 and 41 kDa, in rat fat cell membranes. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6388254&form=6&db=m Selective blockage by islet-activating protein, pertussis toxin, of negative signal transduction from receptors to adenylate cyclase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6388572&form=6&db=m Effect of Bordetella pertussis toxin on ADP-ribosylation of membrane proteins, adenylate cyclase activity and insulin release in rat pancreatic islets. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6424879&form=6&db=m [Pertussis toxin stimulates brain adenyl cyclase and induces ADP ribosylation of a 40,000 dalton membrane protein] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6434346&form=6&db=m Oocyte adenylyl cyclase contains Ni, yet the guanine nucleotide-dependent inhibition by progesterone is not sensitive to pertussis toxin. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6437813&form=6&db=m Ni-mediated inhibition of human platelet adenylate cyclase by thrombin. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6439557&form=6&db=m Does the guanine nucleotide regulatory protein Ni mediate progesterone inhibition of Xenopus oocyte adenylate cyclase? ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6439719&form=6&db=m Effects of guanyl nucleotides and rhodopsin on ADP-ribosylation of the inhibitory GTP-binding component of adenylate cyclase by pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6539707&form=6&db=m Pertussis toxin blocks the action of morphine, norepinephrine and clonidine on isolated guinea-pig ileum. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6539777&form=6&db=m Glucagon-induced heterologous desensitization of the MDCK cell adenylyl cyclase. Increases in the apparent levels of the inhibitory regulator (Ni). diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6541059&form=6&db=m Chemical modification of islet-activating protein, pertussis toxin. Essential role of free amino groups in its lymphocytosis-promoting activity. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6541517&form=6&db=m Effect of pertussis toxin on normorphine-dependence and on acute inhibitory effects of normorphine and clonidine in guinea-pig isolated ileum. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6541752&form=6&db=m Progesterone inhibition of Xenopus oocyte adenylate cyclase is not mediated via the Bordetella pertussis toxin substrate. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6542069&form=6&db=m Bordetella pertussis infection in mice: correlation of specific antibodies against two antigens, pertussis toxin, and filamentous hemagglutinin with mouse protectivity in an intracerebral or aerosol challenge system. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6542360&form=6&db=m The relationship between pertussis-toxin-induced ADP-ribosylation of a plasma-membrane protein and reversal of muscarinic inhibition of prolactin secretion in GH3 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6609000&form=6&db=m Effects of pertussis toxin (PT) on T-cell populations sensitized for delayed-type hypersensitivity in mice. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6682634&form=6&db=m Pertussis toxin uncouples dopamine agonist inhibition of prolactin release. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6682833&form=6&db=m Induction of a novel morphological response in Chinese hamster ovary cells by pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6683482&form=6&db=m The A protomer of islet-activating protein, pertussis toxin, as an active peptide catalyzing ADP-ribosylation of a membrane protein. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6686037&form=6&db=m Pertussis toxin reverses Gpp(NH)p inhibition of basal and forskolin activated adipocyte adenylate cyclase. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6687224&form=6&db=m Functional uncoupling of muscarinic receptors from adenylate cyclase in rat cardiac membranes by the active component of islet-activating protein, pertussis toxin. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7473141&form=6&db=m Serotonin stimulates rapid increase of inositol 1,4,5-trisphosphate in ovine uterine artery: correlation with contractile state. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7473158&form=6&db=m Prostaglandin E2 contracts vascular smooth muscle and inhibits potassium currents in vascular smooth muscle cells of rat tail artery. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7473179&form=6&db=m Regulation of striatal cyclic-3',5'-adenosine monophosphate accumulation and GABA release by glutamate metabotropic and dopamine D1 receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7473226&form=6&db=m beta-adrenergic and cholinergic modulation of the inwardly rectifying K+ current in guinea-pig ventricular myocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7473227&form=6&db=m Beta-adrenergic and cholinergic modulation of inward rectifier K+ channel function and phosphorylation in guinea-pig ventricle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7473877&form=6&db=m Expression of the nerve growth factor gene is controlled by the microtubule network. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7475348&form=6&db=m Age-dependent changes in response of rat prostatic tissues to isoproterenol and forskolin: changes with sexual maturation in function of G proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7475894&form=6&db=m Effects of calcium channel antagonists and pertussis toxin on noradrenaline-induced contractions in pulmonary artery from pulmonary hypertensive rats. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7475913&form=6&db=m Inhaled Bordetella pertussis vaccine decreases airway responsiveness in guinea pigs. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7476895&form=6&db=m Reversible modulation of opioid receptor binding in intact neural cells by endogenous guanosine triphosphate. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7476905&form=6&db=m Lysophosphatidic acid regulation of cyclic AMP accumulation in cultured human airway smooth muscle cells. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7476907&form=6&db=m Mutation of Asp100 in the second transmembrane domain of the cholecystokinin B receptor increases antagonist binding and reduces signal transduction. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7477883&form=6&db=m Peripheral nociceptive effects of alpha 2-adrenergic receptor agonists in the rat. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7477899&form=6&db=m Mu-opioid agonist enhancement of prostaglandin-induced hyperalgesia in the rat: a G-protein beta gamma subunit-mediated effect? causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7477916&form=6&db=m Activation of dopamine D4 receptor inhibits an L-type calcium current in cerebellar granule cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7477953&form=6&db=m (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced burst firing is mediated by a native pertussis toxin-sensitive metabotropic receptor at rat dorsolateral septal nucleus neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7479387&form=6&db=m Protein kinase C regulation of the adenylyl cyclase system in rat prostatic epithelium. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7482085&form=6&db=m Subclinical pertussis in incompletely vaccinated and unvaccinated infants. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7483790&form=6&db=m The purification and protective capacity of Bordetella pertussis outer membrane proteins. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7484433&form=6&db=m Cloning, expression and regulation of angiotensin II receptors. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7485445&form=6&db=m Polarized rabbit type 1 angiotensin II receptors manifest differential rates of endocytosis and recycling. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7485836&form=6&db=m Possible role of striatal adenosine in the modulation of acute ethanol-induced motor incoordination in rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7487961&form=6&db=m The photoactivatable NAD+ analogue [32P]2-azido-NAD+ defines intra- and inter-molecular interactions of the C-terminal domain of the G-protein G alpha t. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7487962&form=6&db=m Prolonged elevation of intracellular cyclic AMP levels in U937 cells increases the number of receptors for and the responses to formylmethionyl-leucylphenylalanine, independently of the differentiation process. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7488026&form=6&db=m ATP activates the potassium channel and enhances cytosolic Ca2+ release via a P2Y purinoceptor linked to pertussis toxin-insensitive G-protein in brain artery endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7488087&form=6&db=m Adenylyl cyclase integrates multiple G protein signals to modulate calcium currents in neonatal rabbit heart. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7488643&form=6&db=m The morphologic change of endothelial cells by ancrod-generated fibrin is triggered by alpha v beta 3 integrin binding and the subsequent activation of a G-protein coupled phospholipase C. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7488649&form=6&db=m Khellin, but not 8-methoxypsoralen, inhibits adenylyl cyclase system in HeLa cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7489748&form=6&db=m Pertussis toxin-sensitive GTP-binding proteins regulate activation-induced apoptotic cell death of human natural killer cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7489759&form=6&db=m Are murine marginal-zone macrophages the splenic white pulp analog of high endothelial venules? ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7489818&form=6&db=m Pituitary PRL secretion induced by tetraethylammonium is inhibited by dopamine through D2 receptors. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7489830&form=6&db=m Activation of MAP kinase by the LHRH receptor through a dual mechanism involving protein kinase C and a pertussis toxin-sensitive G protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7490518&form=6&db=m Neutrophil activation in response to immune complex-bearing endothelial cells depends on the functional cooperation of Fc gamma RII (CD32) and Fc gamma RIII (CD16). causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7491266&form=6&db=m ATP and G proteins affect the runup of the Ca2+ current in bovine chromaffin cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7491908&form=6&db=m Suppression of a nonselective cation conductance by substance P in cochlear outer hair cells. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7491918&form=6&db=m Effects of fluoride and cholera and pertussis toxins on sensory transduction in the carotid body. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7491958&form=6&db=m EGF inhibits secretagogue-induced cAMP production and amylase secretion by Gi proteins in pancreatic acini. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7491963&form=6&db=m Signal-transduction pathways causing slow synaptic excitation in guinea pig myenteric AH neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7491965&form=6&db=m Expression of somatostatin receptor genes and their role in inhibiting Cl- secretion in HT-29cl.19A colonocytes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7491984&form=6&db=m Mechanism of impaired beta-adrenoceptor responsiveness in atopic sensitized airway smooth muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7492305&form=6&db=m Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7494372&form=6&db=m Expression of alpha 2-receptor-mediated responses by insulin in primary culture of rat hepatocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7498464&form=6&db=m The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7500129&form=6&db=m Somatostatin modulates high-voltage-activated Ca2+ channels in freshly dissociated rat hippocampal neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7500151&form=6&db=m Dopaminergic transmission between identified neurons from the mollusk, Lymnaea stagnalis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7502706&form=6&db=m EndothelinB receptor activation enhances parathyroid hormone-induced calcium signals in UMR-106 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7502896&form=6&db=m Secretory IgA against pertussis toxin and surface structures of Bordetella pertussis in saliva of children with culture proven pertussis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7503257&form=6&db=m Adenosine A1 receptor-induced upregulation of protein kinase C: role of pertussis toxin-sensitive G protein(s). therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7504033&form=6&db=m Antiinflammatory effects in experimental meningitis of prokaryotic peptides that mimic selectins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7504105&form=6&db=m Cellular mechanism of acetylcholine-induced response in dissociated outer hair cells of guinea-pig cochlea. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7504109&form=6&db=m Hyperpolarizing muscarinic responses of freshly dissociated rat hippocampal CA1 neurones. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7504723&form=6&db=m Presynaptic inhibition of excitatory synaptic transmission mediated by alpha adrenergic receptors in area CA3 of the rat hippocampus in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7505245&form=6&db=m ADP ribosylation by cholera toxin identifies three G-proteins that are activated by the galanin receptor. Studies with RINm5F cell membranes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7505726&form=6&db=m Lipopolysaccharide induces interleukin-6 release from rat peritoneal macrophages in vitro: evidence for a novel mechanism. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7505759&form=6&db=m Histamine H3-receptor-induced inhibition of duodenal cholinergic transmission is independent of intracellular cyclic AMP and GMP. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7507323&form=6&db=m Protein tyrosine phosphatase inhibition by angiotensin II in rat pheochromocytoma cells through type 2 receptor, AT2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7507837&form=6&db=m The D2 dopamine receptor mediates inhibition of growth in GH4ZR7 cells: involvement of protein kinase-C epsilon. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7507893&form=6&db=m Neutralizing antibodies and immunoprotection against pertussis and tetanus obtained by use of a recombinant pertussis toxin-tetanus toxin fusion protein. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7508196&form=6&db=m Characterization of galanin receptor in canine small intestinal circular muscle synaptosomes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7508351&form=6&db=m Inhibitory effect of octopamine on the release of endogenous acetylcholine from isolated myenteric synaptosomes of guinea-pig. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7508438&form=6&db=m Sulfatides trigger increase of cytosolic free calcium and enhanced expression of tumor necrosis factor-alpha and interleukin-8 mRNA in human neutrophils. Evidence for a role of L-selectin as a signaling molecule. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7510256&form=6&db=m Structural relationship between the S1 and S4 subunits of pertussis toxin. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7511568&form=6&db=m Parathyroid hormone/adenylate cyclase coupling in vascular smooth muscle cells. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7511663&form=6&db=m Ligand-induced adhesion to activated endothelium and to vascular cell adhesion molecule-1 in lymphocytes transfected with the N-formyl peptide receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7512360&form=6&db=m Evaluation of the role of second messenger systems in tumor necrosis factor-stimulated resorption of fetal rat limb bones. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7512953&form=6&db=m D4 dopamine receptor-mediated signaling events determined in transfected Chinese hamster ovary cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7514261&form=6&db=m The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7514403&form=6&db=m Regulation of p42 and p44 MAP kinase isoforms in Rat-1 fibroblasts stably transfected with alpha 2C10 adrenoreceptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7514575&form=6&db=m The 70-kilodalton pertussis toxin-binding protein in Jurkat cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7514793&form=6&db=m Effects of galanin on amylase secretion from dispersed rat pancreatic acini. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7514801&form=6&db=m Amylin (islet amyloid polypeptide) inhibition of insulin release in the perfused rat pancreas: implication of the adenylate cyclase/cAMP system. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7515875&form=6&db=m Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide-dependent activation of membrane-bound NO synthase in smooth muscle mediated by pertussis toxin-sensitive Gi1-2. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7515926&form=6&db=m Tyrosine phosphorylation in activated human neutrophils. Comparison of the effects of different classes of agonists and identification of the signaling pathways involved. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7516398&form=6&db=m The chemokine RANTES is more than a chemoattractant: characterization of its effect on human eosinophil oxidative metabolism and morphology in comparison with IL-5 and GM-CSF. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7516687&form=6&db=m Angiotensin II inhibits calcium and M current channels in rat sympathetic neurons via G proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7517637&form=6&db=m Somatostatin inhibits CCK release by inhibiting secretion and action of CCK-releasing peptide. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7518515&form=6&db=m Endothelins stimulate cyclic AMP accumulation in the isolated rat anterior pituitary gland: possible involvement of ETA receptor activation and prostaglandin E2 production. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7519010&form=6&db=m Regulation of endothelin-1- and lysophosphatidic acid-stimulated tyrosine phosphorylation of focal adhesion kinase (pp125fak) in Rat-1 fibroblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7519011&form=6&db=m Maitotoxin activates cation channels distinct from the receptor-activated non-selective cation channels of HL-60 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7521466&form=6&db=m Verapamil has antiarrhythmic effects that are mediated in brain through endogenous opioids. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7521636&form=6&db=m A randomized controlled trial of two acellular pertussis-diphtheria-tetanus vaccines in primary immunization in Ghana: antibody responses and adverse reactions. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7522276&form=6&db=m An excitatory muscarinic response in neonatal rat ventricular myocytes and its modulation by sympathetic innervation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7523149&form=6&db=m Neuropeptide Y and truncated neuropeptide Y analogs evoke histamine release from rat peritoneal mast cells. A direct effect on G proteins? ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7523318&form=6&db=m Myeloid cell proliferation stimulated by Steel factor is pertussis toxin sensitive and enhanced by cholera toxin. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7523417&form=6&db=m Dopamine-induced inhibition of endogenous acetylcholine release from the isolated ileal synaptosomal preparations of guinea-pig mediated via alpha-adrenoceptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7523590&form=6&db=m Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7523751&form=6&db=m Coexisting NPY and NE synergistically regulate renal tubular Na+, K(+)-ATPase activity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7524050&form=6&db=m Galanin induces opposite effects via different intracellular pathways in smooth muscle cells from dog colon. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7524497&form=6&db=m Multiple effector coupling of somatostatin receptor subtype SSTR1. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7524717&form=6&db=m Interleukin-1 stimulates the expression of type I and type II interleukin-1 receptors in the rat insulinoma cell line Rinm5F; sequencing a rat type II interleukin-1 receptor cDNA. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7525030&form=6&db=m Angiotensin II induced alteration of cyclic adenosine 3',5'-monophosphate generation in the hypertrophic myocardium of Dahl salt-sensitive rat on a high-salt diet. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7525254&form=6&db=m Effects of parathyroid hormone on cytosolic calcium of rat adipocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7525318&form=6&db=m Dual modulation by adenosine of ATP-activated channels through GTP-binding proteins in rat pheochromocytoma PC12 cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7525555&form=6&db=m Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7525719&form=6&db=m C-C chemokines induce the chemotaxis of NK and IL-2-activated NK cells. Role for G proteins. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7525895&form=6&db=m Modulation of Ca2+ channels by PTX-sensitive G-proteins is blocked by N-ethylmaleimide in rat sympathetic neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7526297&form=6&db=m CCK-8-evoked cationic currents in substantia nigra dopaminergic neurons are mediated by InsP3-induced Ca2+ release. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7526655&form=6&db=m Role of positive charges of neuropeptide Y fragments in mast cell activation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7526867&form=6&db=m Multiple mechanisms of arachidonic acid release in Chinese hamster ovary cells transfected with cDNA of substance P receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7527160&form=6&db=m Postreceptor signal transduction mechanisms involved in octreotide-induced inhibition of angiogenesis. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7527606&form=6&db=m G-proteins in alpha 1-adrenoceptor mediated prostatic smooth muscle contraction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7527727&form=6&db=m [Physiopathological role of low affinity IgE receptor (CD23) in hematopoietic cells] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7528010&form=6&db=m Inhibition by somatostatin of amylase secretion induced by calcium and cyclic AMP in rat pancreatic acini. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7529800&form=6&db=m Chemotactic agonists induce cytokine generation in eosinophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7529999&form=6&db=m Possible involvement of protein kinase C and low molecular weight GTP-binding proteins in thrombin-induced histamine secretion in human platelets. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7530278&form=6&db=m Characterization of nitric oxide-stimulated ADP-ribosylation of various proteins from the mouse macrophage cell line ANA-1 using sodium nitroprusside and the novel nitric oxide-donating compound diethylamine dinitric oxide. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7530955&form=6&db=m Alpha 2A-adrenoceptors mediate activation of non-selective cation channels via Gi-proteins in human erythroleukaemia (HEL) cells. No evidence for a functional role of imidazoline receptors in modulating calcium. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7531645&form=6&db=m The human galanin receptor: ligand-binding and functional characteristics in the Bowes melanoma cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7531819&form=6&db=m Effect of PT-treatment on ANP-mediated inhibition of adenylate cyclase and amylase release in rat parotid gland. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7532011&form=6&db=m Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7532733&form=6&db=m Datura stramonium agglutinin released histamine from rat peritoneal mast cells that was inhibited by pertussis toxin, haptenic sugar and N-acetylglucosamine-specific lectins: involvement of glycoproteins with N-acetylglucosamine residues. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7533476&form=6&db=m Study of the activation mechanism of adriamycin on rat mast cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7534066&form=6&db=m Tyrosine phosphorylation induced by cross-linking of Fc gamma-receptor type II in human neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7534345&form=6&db=m Functional interaction of melatonin receptors and D1 dopamine receptors in cultured chick retinal neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7535119&form=6&db=m Ca2+ channel inhibition by kappa opioid receptors expressed in Xenopus oocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7535138&form=6&db=m Lectin domains in the toxin of Bordetella pertussis: selectin mimicry linked to microbial pathogenesis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7535266&form=6&db=m Gi2 and Gi3 proteins mediate the inhibition of adenylyl cyclase by galanin in the RINm5F cell. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7535392&form=6&db=m Glutamate-induced swelling of single astroglial cells in primary culture. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7536161&form=6&db=m Human and rat cutaneous mast cells: involvement of a G protein in the response to peptidergic stimuli. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7536288&form=6&db=m Elucidation of linear epitopes of pertussis toxin using overlapping synthetic decapeptides: identification of a human B-cell determinant in the S1 subunit indicative of acute infections. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7536803&form=6&db=m Adenosine A1 agonists and the Ca2+ channel agonist bay K 8644 produce a synergistic stimulation of the GTPase activity of Go in rat frontal cortical membranes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7537143&form=6&db=m Attenuation of parasite cAMP levels in T. cruzi-host cell membrane interactions in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7538029&form=6&db=m The opioid peptide dynorphin modulates AMPA and kainate responses in acutely isolated neurons from the dorsal horn. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7538571&form=6&db=m Fast, local signal transduction between the mu opioid receptor and Ca2+ channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7538607&form=6&db=m Autonomic regulation of cardiac chloride current. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7539557&form=6&db=m Regulation of prostatic smooth muscle contractility by intracellular second messengers: implications for the conservative treatment of benign prostatic hyperplasia. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7540143&form=6&db=m Structural requirements for neuropeptide Y in mast cell and G protein activation. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7542183&form=6&db=m Alpha-adrenergic control of volume-regulated Cl- currents in rabbit atrial myocytes. Characterization of a novel ionic regulatory mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7542217&form=6&db=m Copresence of prostaglandin EP2 and EP3 receptors on gastric enterochromaffin-like cell carcinoid in African rodents. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7542901&form=6&db=m Role of calcium channels in parathyroid hormone secretion. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7543570&form=6&db=m Inhibition of L-type calcium currents in guinea pig ventricular myocytes by the kappa-opioid agonist U50488H does not involve binding to opiate receptors. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7543575&form=6&db=m Neuropeptide Y (18-36) modulates chromaffin cell catecholamine secretion by blocking the nicotinic receptor ion channel. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7544292&form=6&db=m Cannabinoids enhance human B-cell growth at low nanomolar concentrations. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7544531&form=6&db=m G protein G alpha i-2 inhibits outwardly rectifying chloride channels in human airway epithelial cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7544679&form=6&db=m Study of the activation mechanism of human GRF(1-29)NH2 on rat mast cell histamine release. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7545306&form=6&db=m Calcium-and G-protein-related spasmolytic effects of nonsteroidal anti-inflammatory drugs on rat uterus contractions in vitro. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7545394&form=6&db=m Identification of alpha-subunits of trimeric GTP-binding proteins in human platelets by RT-PCR. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7545457&form=6&db=m Angiogenic factors stimulate mast-cell migration. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7545885&form=6&db=m Clonidine and cirazoline inhibit activation of nicotinic channels in PC-12 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7549512&form=6&db=m Induction of eosinophil cytokine generation by chemoattractants. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7549983&form=6&db=m A Bordetella pertussis acellular vaccine candidate: antigenic characterization and antibody induction. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7551678&form=6&db=m Platelet-activating factor mediated potentiation of stimulation-evoked catecholamine release and the rise in intracellular free Ca2+ concentration in adrenal chromaffin cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7552360&form=6&db=m Neurotensin increases the cationic conductance of rat substantia nigra dopaminergic neurons through the inositol 1,4,5-trisphosphate-calcium pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7554210&form=6&db=m Mechanisms of ischemic preconditioning in rat hearts. Involvement of alpha 1B-adrenoceptors, pertussis toxin-sensitive G proteins, and protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7554953&form=6&db=m Cementum specific components which influence periodontal connective tissue cells. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7556653&form=6&db=m Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through Gi and Gz proteins. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7556874&form=6&db=m The D2 receptor: blocked transcription in GH3 cells and cellular pathways employed by D2A to regulate prolactin promoter activity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7556978&form=6&db=m Interleukin-1 beta inhibition of insulin release in rat pancreatic islets: possible involvement of G-proteins in the signal transduction pathway. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7557463&form=6&db=m Cloning and characterization of a G protein alpha-subunit-encoding gene from the basidiomycete, Coprinus congregatus. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7558245&form=6&db=m Interferon-gamma and lipopolysaccharide reduce cAMP responses in cultured glial cells: reversal by a type IV phosphodiesterase inhibitor. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7558300&form=6&db=m Pertussis toxin export genes are regulated by the ptx promoter and may be required for efficient translation of ptx mRNA in Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7559406&form=6&db=m alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, but not N-methyl-D-aspartate, activates mitogen-activated protein kinase through G-protein beta gamma subunits in rat cortical neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7559812&form=6&db=m Ca2+ influx, phosphoinositide hydrolysis, and histamine release induced by lysophosphatidylserine in mast cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7561109&form=6&db=m Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7561523&form=6&db=m Monomeric human IgE evokes a transient calcium rise in individual human neutrophils. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7561856&form=6&db=m Opioid-induced increase in [Ca2+]i in ND8-47 neuroblastoma x dorsal root ganglion hybrid cells is mediated through G protein-coupled delta-opioid receptors and desensitized by chronic exposure to opioid. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7565012&form=6&db=m Identification of binding proteins for pertussis toxin on pancreatic beta cell-derived insulin-secreting cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7565458&form=6&db=m Activation of the Ca2+ message system by parathyroid hormone is dependent on the cell cycle. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7565624&form=6&db=m Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7566640&form=6&db=m Pharmacological characterization of alpha 2-adrenoceptor regulated serotonin release in the rat hippocampus. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7566687&form=6&db=m In vitro effect of chlorpyrifos oxon on muscarinic receptors and adenylate cyclase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7567283&form=6&db=m Local massage after vaccination enhances the immunogenicity of diphtheria-tetanus-pertussis vaccine. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7568008&form=6&db=m A trace component of ginseng that inhibits Ca2+ channels through a pertussis toxin-sensitive G protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7568118&form=6&db=m G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7568126&form=6&db=m 12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7568154&form=6&db=m The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7573445&form=6&db=m Novel model of integration of signaling pathways in rat pancreatic acinar cells. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7573478&form=6&db=m P2 purinoceptor stimulation attenuates PTH inhibition of phosphate uptake by a G protein-dependent mechanism. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7573520&form=6&db=m Transmembrane mechanochemical coupling in cardiac myocytes: novel activation of Gi by hyposmotic swelling. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7574062&form=6&db=m Role of pertussis toxin-sensitive G-proteins in the analgesic and anesthetic actions of alpha 2-adrenergic agonists in the rat. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7575429&form=6&db=m The purification of a cysteine-dependent NAD+ glycohydrolase activity from bovine erythrocytes and evidence that it exhibits a novel ADP-ribosyltransferase activity. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7575464&form=6&db=m Extracellular ATP activates different signalling pathways in rat Sertoli cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7575606&form=6&db=m G-protein modulation of alpha 1A (P/Q) type calcium channel expressed in GH3 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7576493&form=6&db=m Vasopressin activates phospholipase D through pertussis toxin-insensitive GTP-binding protein in aortic smooth muscle cells: function of Ca2+/calmodulin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7578017&form=6&db=m Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7578277&form=6&db=m Modulation by 1,25(OH)2-vitamin D3 of the adenylyl cyclase/cyclic AMP pathway in rat and chick myoblasts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7579797&form=6&db=m Utilization of sialic acid-binding synthetic peptide sequences derived from pertussis toxin as novel anti-inflammatory agents. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7580873&form=6&db=m Facilitation and inhibition of G-protein regulated protein secretion by melatonin. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7581020&form=6&db=m Pertussis toxin from Bordetella pertussis blocks neutrophil migration and neutrophil-dependent edema in response to inflammation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7581032&form=6&db=m The effects of endothelin on vascular tonus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7582457&form=6&db=m Phosphorylation- and voltage-dependent inhibition of neuronal calcium currents by activation of human D2(short) dopamine receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7582524&form=6&db=m Ca(2+)-dependent and -independent mechanism of cyclic-AMP reduction: mediation by bradykinin B2 receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7583103&form=6&db=m Coincidence detection at the level of phospholipase C activation mediated by the m4 muscarinic acetylcholine receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7583318&form=6&db=m Multiple effects of opiates on intracellular calcium level and on calcium uptake in three neuronal cell lines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7583584&form=6&db=m Stimulation of Gs and inhibition of Gi protein functions by minimally oxidized LDL. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7587646&form=6&db=m Somatostatin modulates voltage-dependent Ca2+ channels in GH3 cells via a specific G(o) splice variant. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7587655&form=6&db=m Characterization of somatostatin receptor subtypes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7588379&form=6&db=m Stimulation of cortisol production through angiotensin AT2 receptors in bovine fasciculata cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7590104&form=6&db=m PEI6, a new basic secretagogue in rat peritoneal mast cells: characteristics of polyethylenimine PEI6 resemble those of compound 48/80. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7591017&form=6&db=m Thromboxane A2 and vascular smooth muscle cell proliferation. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7592424&form=6&db=m Synergistic binding of RNA polymerase and BvgA phosphate to the pertussis toxin promoter of Bordetella pertussis. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7592645&form=6&db=m Sphingosylphosphorylcholine activation of mitogen-activated protein kinase in Swiss 3T3 cells requires protein kinase C and a pertussis toxin-sensitive G protein. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7592725&form=6&db=m Phosphatidic acid and lysophosphatidic acid induce haptotactic migration of human monocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7592840&form=6&db=m Hypertrophic agonists stimulate the activities of the protein kinases c-Raf and A-Raf in cultured ventricular myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7592844&form=6&db=m Pertussis toxin inhibits phospholipase C activation and Ca2+ mobilization by sphingosylphosphorylcholine and galactosylsphingosine in HL60 leukemia cells. Implications of GTP-binding protein-coupled receptors for lysosphingolipids. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7593174&form=6&db=m Chemokines regulate cellular polarization and adhesion receptor redistribution during lymphocyte interaction with endothelium and extracellular matrix. Involvement of cAMP signaling pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7593220&form=6&db=m Thrombin activates mitogen-activated protein kinase in primary astrocyte cultures. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7593238&form=6&db=m Chemoattractant-induced activation of vacuolar H+ pumps and of an H(+)-selective conductance in neutrophils. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7593640&form=6&db=m Somatostatin coordinately regulates glucagon gene expression and exocytosis in HIT-T15 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7594603&form=6&db=m IFN-gamma up-regulates the human C5a receptor (CD88) in myeloblastic U937 cells and related cell lines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7595499&form=6&db=m Angiotensin II type 2 receptor-mediated stimulation of protein phosphatase 2A in rat hypothalamic/brainstem neuronal cocultures. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7595536&form=6&db=m Activation of G proteins bidirectionally affects apoptosis of cultured cerebellar granule neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7596130&form=6&db=m Angiopeptin (BIM23014C) inhibits vascular smooth muscle cell migration in vitro through a G-protein-mediated pathway and is associated with inhibition of adenylyl cyclase and cyclic AMP accumulation. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7601096&form=6&db=m The guanine-nucleotide-binding protein subunit G alpha i2 is involved in calcium activation of phospholipase A2. Effects of the dominant negative G alpha i2 mutant, [G203T]G alpha i2, on activation of phospholipase A2 in Chinese hamster ovary cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7601100&form=6&db=m Cloning of a molluscan G protein alpha subunit of the Gq class which is expressed differentially in identified neurons. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7601846&form=6&db=m Identification of a Bordetella pertussis regulatory factor required for transcription of the pertussis toxin operon in Escherichia coli. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7602094&form=6&db=m IL-1 stimulates a diverging signaling pathway in EL4 6.1 thymoma cells. IL-2 release, but not IL-2 receptor expression, is sensitive to pertussis toxin. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7602111&form=6&db=m Tyrosine phosphorylation is required for eosinophil degranulation induced by immobilized immunoglobulins. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7602150&form=6&db=m Comparison of five calculation modes for antibody ELISA procedures using pertussis serology as a model. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7602232&form=6&db=m Mechanisms for lipoxin A4-induced neutrophil-dependent cytotoxicity for human endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7603457&form=6&db=m Adenosine A1 receptor-mediated activation of phospholipase C-beta 3 in intestinal muscle: dual requirement for alpha and beta gamma subunits of Gi3. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7603625&form=6&db=m gamma-Hydroxybutyrate receptor binding in rat brain is inhibited by guanyl nucleotides and pertussis toxin. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7607603&form=6&db=m Effect of cholera toxin and pertussis toxin on the growth of A431 cells: kinetics of cyclic AMP and inositol trisphosphate in toxin-treated cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7608776&form=6&db=m Pancreatic polypeptide inhibits calcium channels in rat sympathetic neurons via two signaling pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7609785&form=6&db=m Cationic-amphiphilic arpromidine-derived guanidines and a histamine trifluoromethyl-toluidide derivative may activate pertussis toxin-sensitive G-proteins by a receptor-independent mechanism. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7613525&form=6&db=m Pertussis toxin sensitive endothelin-1 coupling to inositol phosphate formation via a GTP-binding protein: comparison in SHR and WKY cultured aortic smooth muscle cells. causal interaction,ongoing research,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7615018&form=6&db=m Binding, coupling, and mRNA subtype heterogeneity of alpha 1-adrenergic receptors in cultured human RPE. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7615534&form=6&db=m Expression of the type-II phospholipase A2 in alveolar macrophages. Down-regulation by an inflammatory signal. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7615693&form=6&db=m Trimeric G proteins regulate the cytosol-induced redistribution of Golgi enzymes into the endoplasmic reticulum. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7615808&form=6&db=m Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7616390&form=6&db=m Differential coupling of m1, m2 and m3 muscarinic receptor subtypes to inositol 1,4,5-trisphosphate and adenosine 3',5'-cyclic monophosphate accumulation in Chinese hamster ovary cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7616413&form=6&db=m Adenosine A1 and A2b receptors coupled to distinct interactive signaling pathways in intestinal muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7616844&form=6&db=m Inositol phosphates modulate human red blood cell Ca(2+)-adenosine triphosphatase activity in vitro by a guanine nucleotide regulatory protein. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7619076&form=6&db=m Differential coupling of the formyl peptide receptor to adenylate cyclase and phospholipase C by the pertussis toxin-insensitive Gz protein. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7619502&form=6&db=m Oxytocin induced a biphasic increase in the intracellular Ca2+ concentration of porcine myometrial cells: participation of a pertussis toxin-insensitive G-protein, inositol 1,4,5-trisphosphate-sensitive Ca2+ pool, and Ca2+ channels. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7619532&form=6&db=m Pertussis toxin specifically inhibits growth cone guidance by a mechanism independent of direct G protein inactivation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7620719&form=6&db=m Enhancement of cyclic AMP accumulation mediated by 5-HT after chronic amitriptyline treatment in NG 108-15 cells. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7620887&form=6&db=m The action of 5-HT on calcium-dependent potassium channels and on the spinal locomotor network in lamprey is mediated by 5-HT1A-like receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7621908&form=6&db=m Coupling of muscarinic m1, m2 and m3 acetylcholine receptors, expressed in Chinese hamster ovary cells, to pertussis toxin-sensitive/insensitive guanine nucleotide-binding proteins. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7621912&form=6&db=m Noradrenaline-mediated contractions of ovine uterine artery: role of inositol 1,4,5-trisphosphate. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7622254&form=6&db=m Localization of the promoter for the ptl genes of Bordetella pertussis, which encode proteins essential for secretion of pertussis toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7622449&form=6&db=m G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7623277&form=6&db=m Inhibitory effect of muscarinic receptor activation on Ca2+ channel current in smooth muscle cells of guinea-pig ileum. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7624035&form=6&db=m Muscarine increases a voltage-independent potassium conductance through an M4 receptor in rat dorsolateral septal nucleus neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7626007&form=6&db=m Activation of the mitogen-activated protein kinase cascade by pertussis toxin-sensitive and -insensitive pathways in cultured ventricular cardiomyocytes. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7626289&form=6&db=m Muscarinic regulation of cyclic AMP in bovine trachealis cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7628380&form=6&db=m Effects of somatostatin on cultured human mesangial cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7628910&form=6&db=m Intrathecal pertussis toxin but not cyclic AMP blocks kappa opioid-induced antinociception in rat. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7629104&form=6&db=m Hydrophobicity and subunit interactions of rod outer segment proteins investigated using Triton X-114 phase partitioning. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7629515&form=6&db=m Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7630313&form=6&db=m Inhibition of angiotensin II-stimulated inositol phosphate production by D2-dopamine receptor is calcium-dependent in human trophoblastic cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7630424&form=6&db=m Analysis of receptor-G protein interactions in permeabilized cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7630487&form=6&db=m Inhibition of N-type Ca2+ channel currents in human neuroblastoma (SH-SY5Y) cells by muscarine via stimulation of M3 receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7631795&form=6&db=m Somatostatin inhibits AP-1 function via multiple protein phosphatases. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7631804&form=6&db=m Agonist-mediated activation of PLA2 initiates Ca2+ mobilization in intestinal longitudinal smooth muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7631958&form=6&db=m Interaction of halothane with inhibitory G-proteins in the human myocardium. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7634099&form=6&db=m Structure of a pertussis toxin-sugar complex as a model for receptor binding. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7635171&form=6&db=m Involvement of protein kinase C activation in alpha 2-adrenoceptor-mediated contractions of rabbit saphenous vein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7635969&form=6&db=m Enhanced G protein activation in immortalized lymphoblasts from patients with essential hypertension. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7636186&form=6&db=m A novel biologic function of serum amyloid A. Induction of T lymphocyte migration and adhesion. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7636648&form=6&db=m Effect of priming with diphtheria and tetanus toxoids combined with whole-cell pertussis vaccine or with acellular pertussis vaccine on the safety and immunogenicity of a booster dose of an acellular pertussis vaccine containing a genetically inactivated pertussis toxin in fifteen- to twenty-one-month-old children. Italian Multicenter Group for the Study of Recombinant Acellular Pertussis Vaccine. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7636757&form=6&db=m Colchicine and cytochalasin B enhance cyclic AMP accumulation via postreceptor actions. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7636809&form=6&db=m G protein expression and second messenger formation in human granulosa cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7637260&form=6&db=m Role of adenosine on glucagon-induced cAMP in a human cortical collecting duct cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7637807&form=6&db=m Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7642531&form=6&db=m A novel G protein alpha subunit containing atypical guanine nucleotide-binding domains is differentially expressed in a molluscan nervous system. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7643109&form=6&db=m Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates adenylyl cyclase and phospholipase C activity in rat cerebellar neuroblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7643119&form=6&db=m Coupling of the cloned mu-opioid receptor with the omega-conotoxin-sensitive Ca2+ current in NG108-15 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7644129&form=6&db=m ATP-evoked potassium currents in rat striatal neurons are mediated by a P2 purinergic receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7646551&form=6&db=m Lipocortin-1 and the control of arachidonic acid release in cell signalling. Glucocorticoids (changed from glucorticoids) inhibit G protein-dependent activation of cPLA2 activity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7647103&form=6&db=m 1,25(OH)2-vitamin D-3 stimulates phospholipase A2 activity via a guanine nucleotide-binding protein in chick myoblasts. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7647969&form=6&db=m Effects of GTP gamma S on muscarinic receptor-stimulated inositol phospholipid hydrolysis in permeabilized smooth muscle from the small intestine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7648317&form=6&db=m AB5 toxins. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7648795&form=6&db=m The effects of in vitro and in vivo exposure to insulin upon prostaglandin E1 stimulation of platelet adenylate cyclase activity in healthy subjects. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7649075&form=6&db=m Internalization of the radioiodinated somatostatin analog [125I-Tyr3]octreotide by mouse and human pituitary tumor cells: increase by unlabeled octreotide. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7649305&form=6&db=m C-type natriuretic peptide and brain natriuretic peptide inhibit adenylyl cyclase activity: interaction with ANF-R2/ANP-C receptors. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7649993&form=6&db=m Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7650056&form=6&db=m On the mechanisms of the growth-promoting effect of prostaglandins in hepatocytes: the relationship between stimulation of DNA synthesis and signaling mediated by adenylyl cyclase and phosphoinositide-specific phospholipase C. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7650608&form=6&db=m Muscarine inhibits high-threshold calcium currents with two distinct modes in rat embryonic hippocampal neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7651356&form=6&db=m 5-Hydroxytryptamine2A receptors expressed in rat renal mesangial cells inhibit cyclic AMP accumulation. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7651369&form=6&db=m Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7651901&form=6&db=m Chicken liver contains a large quantity of a G-protein-linked neurotensin receptor. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7651936&form=6&db=m A two-dimensional model of cell movement. Well differentiated human rectal adenocarcinoma cells move as coherent sheets upon TPA stimulation. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7652193&form=6&db=m Identification and characterization of functional angiotensin II receptors in human neuroblastoma cells. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7653600&form=6&db=m Luminal prostaglandin E receptors regulate salt and water transport in rabbit cortical collecting duct. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7653652&form=6&db=m Pertussis toxin-sensitive G proteins mediate carbachol-induced REM sleep and respiratory depression. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7656331&form=6&db=m B cell differentiation factor-induced human B cell maturation: stimulation of intracellular calcium release. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7656405&form=6&db=m Modulation by somatostatin of glutamate sensitivity during development of mouse hypothalamic neurons in vitro. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7658384&form=6&db=m Characterization of the G protein coupling of a somatostatin receptor to the K+ATP channel in insulin-secreting mammalian HIT and RIN cell lines. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7659475&form=6&db=m Comparison of 13 acellular pertussis vaccines: overview and serologic response. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7659477&form=6&db=m A randomized comparison of reactogenicity and immunogenicity of two whole-cell pertussis vaccines. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7659478&form=6&db=m Description and evaluation of serologic assays used in a multicenter trial of acellular pertussis vaccines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7659480&form=6&db=m The effect of maternal antibody on the serologic response and the incidence of adverse reactions after primary immunization with acellular and whole-cell pertussis vaccines combined with diphtheria and tetanus toxoids. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7659481&form=6&db=m Effect of gender, race, and parental education on immunogenicity and reported reactogenicity of acellular and whole-cell pertussis vaccines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7659484&form=6&db=m Relationships between functional assays and enzyme immunoassays as measurements of responses to acellular and whole-cell pertussis vaccines. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7662508&form=6&db=m Cell signalling pathway involved in PACAP-induced AR4-2J cell proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7662986&form=6&db=m Single-cell analysis of macrophage chemotactic protein-1-regulated cytosolic Ca2+ increase in human adherent monocytes. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7664674&form=6&db=m Effect of ranakinin, a novel tachykinin, on cytosolic free calcium in frog adrenochromaffin cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7664686&form=6&db=m A novel role for testicular descent; temperature-dependent induction of pertussis toxin-sensitive Gi protein function in postnatal rat Leydig cells. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7665400&form=6&db=m Role of G proteins in the vasodilator response to endothelin isopeptides in vivo. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7666185&form=6&db=m Maintained L-type Ca2+ channel activity in excised patches of PTX-treated granule cells of the cerebellum. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7666194&form=6&db=m Growth factor upregulation of a phosphoinositide-coupled metabotropic glutamate receptor in cortical astrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7669227&form=6&db=m Absence of D2S dopamine receptor in the prolactin-secreting MMQ pituitary clone: characterization of a wild D2L receptor coupled to native transduction mechanisms. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7670043&form=6&db=m [The effect of cortisol and pertussis toxin on the cyclic AMP level in human lymphocytes] diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7673118&form=6&db=m Losartan-sensitive AII receptors linked to depolarization-dependent cortisol secretion through a novel signaling pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7674817&form=6&db=m The somatostatin receptor family. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7675047&form=6&db=m A placebo-controlled trial of a pertussis-toxoid vaccine. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7675119&form=6&db=m Acetylcholine and adenosine activate the G protein-gated muscarinic K+ channel in ferret ventricular myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7675952&form=6&db=m Changes in the acoustic startle response and prepulse inhibition of acoustic startle in rats after local injection of pertussis toxin into the ventral tegmental area. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7677415&form=6&db=m Pertussis immunization with acellular vaccines in Ghanaian children. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7677769&form=6&db=m The P2Y purinoceptor-operated potassium channel is possibly regulated by the beta gamma subunits of a pertussis toxin-insensitive G-protein in cultured rat inferior colliculus neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7677848&form=6&db=m Release of guanosine triphosphate binding protein alpha subunits from mouse myocardial membranes: basic properties and their alterations in acute murine Chagas disease. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7678102&form=6&db=m Identification of murine T-cell epitopes on the S4 subunit of pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7678399&form=6&db=m Regulation of cyclic AMP levels by phorbol esters in bovine adrenal medullary cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7678793&form=6&db=m Endothelin receptor subtypes are coupled to adenylate cyclase via different guanyl nucleotide-binding proteins in vasculature. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7678964&form=6&db=m Substance P and somatostatin inhibit calcium channels in rat sympathetic neurons via different G protein pathways. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7679495&form=6&db=m Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7679639&form=6&db=m Localisation of a receptor-recognition domain on the S3 subunit of pertussis toxin by peptide mapping. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7679650&form=6&db=m Chronic myelogenous leukemia-derived basophilic granulocytes express a functional active receptor for the anaphylatoxin C3a. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7679896&form=6&db=m Thrombin Ca(2+)-dependently stimulates protein tyrosine phosphorylation in BC3H1 muscle cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7679952&form=6&db=m Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7680319&form=6&db=m Effects of pertussis toxin on behavioural responses of guinea-pigs to centrally administered substance P, quinpirole, carbachol, U-50,488H, morphine and morphine withdrawal. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7680347&form=6&db=m Structural and functional studies on the G(o) protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7680615&form=6&db=m RANTES and related chemokines activate human basophil granulocytes through different G protein-coupled receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7680717&form=6&db=m Bicarbonate induces sensitization of cyclic AMP accumulation by intact 1321N1 human astrocytoma cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7680879&form=6&db=m Gi alpha and Gi beta are part of a signalling complex in Balb/c3T3 cells: phosphorylation of Gi beta in growth-factor-activated fibroblasts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7681044&form=6&db=m Evidence that lipopolysaccharide and pertussis toxin bind to different domains on the same p73 receptor on murine splenocytes. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7681262&form=6&db=m Regulation of high-conductance anion channels by G proteins and 5-HT1A receptors in CHO cells. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7681476&form=6&db=m Potentiation of NMDA receptor-mediated transmission in turtle cerebellar granule cells by activation of metabotropic glutamate receptors. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7681628&form=6&db=m Adenosine and 5-HT inhibit substance P release from nerve endings in myenteric ganglia by distinct mechanisms. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7681878&form=6&db=m Effect of adenylate cyclase stimulation on meiotic resumption and cyclic AMP content of zona-free and cumulus-enclosed bovine oocytes in vitro. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7682570&form=6&db=m Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7682783&form=6&db=m Chloride channels in myocytes from rabbit colon are regulated by a pertussis toxin-sensitive G protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7683650&form=6&db=m Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signaling by endothelin-1. Cross-talk between G protein-coupled receptors and pp60c-src. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7684340&form=6&db=m The modulation of placental lactogen release by opioids: a role for extracellular calcium. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7684446&form=6&db=m N-acetyl beta-endorphin-(1-31) and substance P regulate the supraspinal antinociception mediated by mu opioid and alpha-2 adrenoceptors but not by delta opioid receptors in the mouse. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7684728&form=6&db=m Identification of B-cell epitopes on the S4 subunit of pertussis toxin. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7685299&form=6&db=m Mimicking of discontinuous epitopes by phage-displayed peptides, II. Selection of clones recognized by a protective monoclonal antibody against the Bordetella pertussis toxin from phage peptide libraries. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7685501&form=6&db=m Alpha 1-adrenoceptor-mediated inhibition of cellular cAMP accumulation in neonatal rat ventricular myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7687295&form=6&db=m GTP-binding proteins regulate high conductance anion channels in rat bile duct epithelial cells. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7687559&form=6&db=m Characterization of the metabotropic glutamate receptor in mouse cerebellar granule cells: lack of effect of 2,3-dihydroxy-6-nitro-7-sulphamoylbenzo(F)-quinoxaline (NBQX). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7687633&form=6&db=m Chemoattraction of neutrophils by substance P and transforming growth factor-beta 1 is inadequately explained by current models of lipid remodeling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7687752&form=6&db=m Muscarinic depression of synaptic transmission and blockade of norepinephrine-induced long-lasting potentiation in the dentate gyrus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7687783&form=6&db=m Photosensory transduction in ciliates. IV. Modulation of the photomovement response of Blepharisma japonicum by cGMP. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7687809&form=6&db=m Protein kinase C activation and positive and negative agonist regulation of 3',5'-cyclic adenosine monophosphate levels in cultured rat Sertoli cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7688189&form=6&db=m Effect of low-density lipoproteins, mevinolin, and G proteins on Ca2+ response in cultured chick atrial cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7688202&form=6&db=m Hydrophobic binding of pertussis toxin is enhanced by oligosaccharide receptors. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7688324&form=6&db=m Mast cell activation by pedicellarial toxin of sea urchin, Toxopneustes pileolus. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7688793&form=6&db=m Prokaryotic peptides that block leukocyte adherence to selectins. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7688806&form=6&db=m Small-conductance Cl- channels in rabbit parietal cells activated by prostaglandin E2 and inhibited by GTP gamma S. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7689056&form=6&db=m Histamine release from basophils in childhood: age dependency and inhibition by pertussis infection and pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7689100&form=6&db=m Role of guanine nucleotide-binding protein and tyrosine kinase in platelet-activating factor activation of phospholipase C in A431 cells: proposal for dual mechanisms. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7689101&form=6&db=m Alpha adrenergic receptor subtypes involved in prostaglandin synthesis are coupled to Ca++ channels through a pertussis toxin-sensitive guanine nucleotide-binding protein. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7689106&form=6&db=m Ca(++)-dependent constitutive nitric oxide synthase is not involved in the cyclic GMP-increasing effects of carbachol in ventricular cardiomyocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7689644&form=6&db=m N-acetylaspartylglutamate inhibits forskolin-stimulated cyclic AMP levels via a metabotropic glutamate receptor in cultured cerebellar granule cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7689832&form=6&db=m Ion fluxes through the progesterone-activated channel of the sperm plasma membrane. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7690103&form=6&db=m Norepinephrine and neuropeptide Y increase intracellular Ca2+ in cultured porcine aortic smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7690361&form=6&db=m A role for extracellular calcium in the regulation of placental lactogen release by angiotensin-II and dopamine in human term trophoblastic cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7690405&form=6&db=m A pharmacological investigation of the contribution of muscarinic receptor-linked potassium channels to the reversal by carbachol of positive inotropic responses of rabbit left atrium to cyclic AMP-generating agents. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7690452&form=6&db=m 3-Isobutyl-1-methylxanthine inhibits sustained calcium current independently of cyclic AMP in neuronal and endocrine cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7690567&form=6&db=m Characterization of the prostaglandin E receptor expressed on a cultured mast cell line, BNu-2cl3. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7690672&form=6&db=m A pharmacological characterization of the mGluR1 alpha subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7691354&form=6&db=m The adenylyl cyclase-cyclic AMP system modulates morphological and functional development of hypothalamic beta-endorphin neurons in culture. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7692136&form=6&db=m Second messenger regulation of lipoprotein uptake by an arterial wall model. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7692386&form=6&db=m Protein kinase C activates the non-selective cation channel in the rabbit portal vein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7692744&form=6&db=m Endogenous somatostatin inhibits histamine release from canine gastric mucosal cells in primary culture. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7693460&form=6&db=m Conformational study of a short Pertussis toxin T cell epitope incorporated in a multiple antigen peptide template by CD and two-dimensional NMR. Analysis of the structural effects on the activity of synthetic immunogens. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7693872&form=6&db=m Pertussis toxin enhances proenkephalin synthesis in bovine chromaffin cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7694069&form=6&db=m Indirect inhibition by bradykinin of cyclic AMP generation in isolated rat glomeruli and mesangial cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7694473&form=6&db=m Biphasic effects of carbachol on stimulated cAMP accumulation in mouse parotid acini. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7694506&form=6&db=m Endothelin B receptor mediates ET-1 effects on cAMP and PGE2 accumulation in rat IMCD. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7694703&form=6&db=m Pharmacologic control of histamine release from human basophils induced by platelet-activating factor. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7695921&form=6&db=m Histamine provokes turnover of inositol phospholipids in guinea pig and human airway epithelial cells via an H1-receptor/G protein-dependent mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7696346&form=6&db=m Mechanism of isoproterenol-induced heterologous desensitization of mucin secretion from rat submandibular glands. Regulation of phosphorylation of Gi proteins controls the cell response to the subsequent stimulation. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7696352&form=6&db=m Calcium inflow in cells transfected with cloned rat and porcine calcitonin receptors. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7700508&form=6&db=m The cloned kappa opioid receptor couples to an N-type calcium current in undifferentiated PC-12 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7702449&form=6&db=m Low levels of pertussis toxin adenosine diphosphate ribosylation in the schizophrenic brain. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7702564&form=6&db=m Intracellular cross-talk between thyrotropin receptor and A1 adenosine receptor in regulation of phospholipase C and adenylate cyclase in COS-7 cells transfected with their receptor genes. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7704425&form=6&db=m D2 receptors mediate dopamine suppression of irANF release and pro-ANF mRNA expression of rat hypothalamic neurons in culture. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7704910&form=6&db=m B cell differentiation factor-induced B cell maturation: regulation via reduction in cAMP. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7705383&form=6&db=m Activation of the respiratory burst in eosinophil leucocytes--a transduction sequence decoupled from cytosolic Ca2+ rise. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7705463&form=6&db=m Activation of metabotropic glutamate receptors by L-AP4 stimulates survival of rat cerebellar granule cells in culture. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7705466&form=6&db=m Bradykinin inhibits adenylate cyclase activity in guinea pig ileum membranes via a separate high-affinity bradykinin B2 receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7705473&form=6&db=m Up-regulation in late pregnancy of both Go1 alpha and Go2 alpha isoforms in human myometrium. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7706288&form=6&db=m Evidence for G beta gamma-mediated cross-talk in primary cultures of lung alveolar cells. Pertussis toxin-sensitive production of cAMP. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7706373&form=6&db=m Mechanical stimulation of skeletal muscle increases prostaglandin F2 alpha production, cyclooxygenase activity, and cell growth by a pertussis toxin sensitive mechanism. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7706413&form=6&db=m Tyrosine phosphorylation is involved in reorganization of the actin cytoskeleton in response to serum or LPA stimulation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7706744&form=6&db=m Phosphorylation, dephosphorylation, and recycling of the C5a receptor in differentiated HL60 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7707287&form=6&db=m Effects of oestradiol and tamoxifen on oxytocin-induced phospholipase C activation in human myometrial cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7708116&form=6&db=m Comparison of alpha 1A- and alpha 1B-adrenoceptor coupling to inositol phosphate formation in rat kidney. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7708214&form=6&db=m Differential involvement of hippocampal G-protein subtypes in the memory process of rats. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7711886&form=6&db=m Biphasic effect of interleukin-1 beta on arginine vasopressin-induced cellular cyclic adenosine monophosphate production in cultured rat renal papillary collecting tubule cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7712007&form=6&db=m G-protein involvement in muscarinic receptor-stimulation of inositol phosphates in longitudinal smooth muscle from the small intestine of the guinea-pig. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7712022&form=6&db=m Inotropic changes induced by fluoroaluminates in rabbit left atrial muscles: possible involvement of G proteins. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7713098&form=6&db=m Cloning, expression and regulation of angiotensin II receptors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7713111&form=6&db=m Contractile function and response to agonists in myocytes from failing human heart. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7713368&form=6&db=m G-proteins in rat blood vessels--I. Identification. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7713369&form=6&db=m G-proteins in rat blood vessels--II. Assessment of functional involvement. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7713868&form=6&db=m Platelet-activating factor stimulates transcription of the heparin-binding epidermal growth factor-like growth factor in monocytes. Correlation with an increased kappa B binding activity. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7713915&form=6&db=m Identification of gangliosides as inhibitors of ADP-ribosyltransferases of pertussis toxin and exoenzyme C3 from Clostridium botulinum. diagnostic usage,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7715738&form=6&db=m Chronic muscarinic cholinoceptor stimulation increases adenylyl cyclase responsiveness in rat cardiomyocytes by a decrease in the level of inhibitory G-protein alpha-subunits. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7716271&form=6&db=m Differential effects of pertussis toxin on body temperature changes induced by neuropeptide Y and NPY2-36. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7717971&form=6&db=m Activation of alpha-2-adrenoceptors results in an increase in F-actin formation in HIT-T15 pancreatic B-cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7717995&form=6&db=m Regulation of fibroblast procollagen production. Transforming growth factor-beta 1 induces prostaglandin E2 but not procollagen synthesis via a pertussis toxin-sensitive G-protein. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7720569&form=6&db=m Roles of heterotrimeric and monomeric G proteins in sperm-induced activation of mouse eggs. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7720630&form=6&db=m Time course of action of pertussis toxin to block the inhibition of stimulated insulin release by norepinephrine. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7720854&form=6&db=m The endozepine ODN stimulates polyphosphoinositide metabolism in rat astrocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7721741&form=6&db=m Truncation of the carboxyl-terminal region of the rat parathyroid hormone (PTH)/PTH-related peptide receptor enhances PTH stimulation of adenylyl cyclase but not phospholipase C. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7721818&form=6&db=m Cyclic GMP-dependent protein kinase blocks pertussis toxin-sensitive hormone receptor signaling pathways in Chinese hamster ovary cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7722425&form=6&db=m Chemoattractant receptor-specific differences in G protein activation rates regulate effector enzyme and functional responses. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7722495&form=6&db=m Differential coupling of D1 and D5 dopamine receptors to guanine nucleotide binding proteins in transfected GH4C1 rat somatomammotrophic cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7722640&form=6&db=m ATP causes release of intracellular Ca2+ via the phospholipase C beta/IP3 pathway in astrocytes from the dorsal spinal cord. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7723660&form=6&db=m Expression and mutagenesis of recombinant cholera toxin A subunit. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7723745&form=6&db=m Stimulation of type II adenylyl cyclase by chemoattractant formyl peptide and C5a receptors. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7723747&form=6&db=m Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7724045&form=6&db=m Protein kinase C mediates neurotensin inhibition of inwardly rectifying potassium currents in rat substantia nigra dopaminergic neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7727785&form=6&db=m Hemolytically inactive C5b67 complex: an agonist of polymorphonuclear leukocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7730015&form=6&db=m Experimental autoimmune anterior uveitis. Induction with melanin-associated antigen from the iris and ciliary body. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7730310&form=6&db=m Structural basis of G protein specificity of human endothelin receptors. A study with endothelinA/B chimeras. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7730331&form=6&db=m Involvement of a pertussis toxin-sensitive G protein in the mitogenic signaling pathways of sphingosine 1-phosphate. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7730638&form=6&db=m Biologic activities of the beta-chemokine TCA3 on neutrophils and macrophages. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7731062&form=6&db=m Selective activation by atrial natriuretic factor of phosphatidylcholine-specific phospholipase activities in purified heart muscle plasma membranes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7731982&form=6&db=m Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7733231&form=6&db=m Increase in [Ca2+]i by CCh in adult rat sympathetic neurons are not dependent on intracellular Ca2+ pools. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7733232&form=6&db=m Adenosine attenuates calcium paradox injury: role of adenosine A1 receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7733240&form=6&db=m Signaling and growth responses of LLC-PK1/Cl4 cells transfected with the rabbit AT1 ANG II receptor. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7733246&form=6&db=m C-type natriuretic peptide neuromodulates via "clearance" receptors. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7733966&form=6&db=m Platelet activating factor activates MAPK and increases in intracellular calcium via independent pathways in B lymphocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7734110&form=6&db=m Acceleration of desipramine-induced changes on the dopamine receptor-coupled adenylate cyclase system by pertussis toxin. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7736503&form=6&db=m Role of sodium-hydrogen exchange in the proliferation of immortalised lymphoblasts from patients with essential hypertension and normotensive subjects. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7737734&form=6&db=m Treatment in hypertensive cardiac hypertrophy, II. Postreceptor events. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7738168&form=6&db=m Angiotensin II upregulates type-1 angiotensin II receptors in renal proximal tubule. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7738830&form=6&db=m Inhibitory effect of adenosine on electrical activity of frog melanotrophs mediated through A1 purinergic receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7739570&form=6&db=m Differential regulation of accessory mitogenic signaling receptors by the T cell antigen receptor. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7739761&form=6&db=m M3 muscarinic receptors on murine HSDM1C1 cells: further functional, regulatory, and receptor binding studies. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7741187&form=6&db=m Mechanisms of human eosinophil activation by complement protein C5a and platelet-activating factor: similar functional responses are accompanied by different morphologic alterations. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7741570&form=6&db=m Adverse events and antibody response to accelerated immunisation in term and preterm infants. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7741705&form=6&db=m Regulation of lysophosphatidic acid-stimulated tyrosine phosphorylation of mitogen-activated protein kinase by protein kinase C- and pertussis toxin-dependent pathways in the endothelial cell line EAhy 926. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7741717&form=6&db=m Metabotropic glutamate receptor analogues inhibit p[NH]ppG-stimulated phospholipase C activity in bovine brain coated vesicles: involvement of a pertussis toxin-sensitive G-protein. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7741762&form=6&db=m Histamine receptor-dependent and/or -independent activation of guanine nucleotide-binding proteins by histamine and 2-substituted histamine derivatives in human leukemia (HL-60) and human erythroleukemia (HEL) cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7742479&form=6&db=m Comparative aspects of the role of neuropeptide Y in the regulation of the vertebrate heart. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7744787&form=6&db=m Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein-dependent mechanism. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7744827&form=6&db=m Synergistic interaction of Y1-neuropeptide Y and alpha 1b-adrenergic receptors in the regulation of phospholipase C, protein kinase C, and arachidonic acid production. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7746270&form=6&db=m kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7746271&form=6&db=m Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7746286&form=6&db=m Gi is involved in ethanol inhibition of L-type calcium channels in undifferentiated but not differentiated PC-12 cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7746465&form=6&db=m Accentuation by pertussis toxin of the 5-hydroxytryptamine-induced potentiation of ATP-evoked responses in rat pheochromocytoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7750573&form=6&db=m A comparison of post-receptor signal transduction events in Jurkat cells transfected with either IL-8R1 or IL-8R2. Chemokine mediated activation of p42/p44 MAP-kinase (ERK-2). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7750984&form=6&db=m NK-LAK induction with IL-2 is regulated by tyrosine phosphorylation of a 105-110 kDa protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7752097&form=6&db=m Kappa opioid receptor-mediated suppression of voltage-activated potassium current in a catecholaminergic neuronal cell line. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7752529&form=6&db=m The effects of endothelin-1 on the PKA-dependent Cl- current in the heart. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7753758&form=6&db=m Effects of zinc on production of active oxygen species by rat neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7753807&form=6&db=m Cannabinoid ligand-receptor signaling in the mouse uterus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7755277&form=6&db=m Mechanisms of cell transformation in the embryonic heart. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7758519&form=6&db=m Immunogenicity and safety of a monovalent, multicomponent acellular pertussis vaccine in 15 month-6-year-old German children. Monovalent Acellular Pertussis Vaccine Study Group. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7758673&form=6&db=m Effects of pertussis toxin and its binding subunit on IL-1 signalling in T cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7759545&form=6&db=m The heterotrimeric G-protein Gi is localized to the insulin secretory granules of beta-cells and is involved in insulin exocytosis. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7760033&form=6&db=m Expression of the mu-opioid receptor in CHO cells: ability of mu-opioid ligands to promote alpha-azidoanilido[32P]GTP labeling of multiple G protein alpha subunits. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7760036&form=6&db=m Anesthetic barbiturates enhance Gs alpha-dependent cyclic AMP production in S49 mouse lymphoma cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7760050&form=6&db=m Regulation of multiple effectors by the cloned delta-opioid receptor: stimulation of phospholipase C and type II adenylyl cyclase. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7760061&form=6&db=m Inhibition of striatal GABA release by the adenosine A2a receptor is not mediated by increases in cyclic AMP. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7760657&form=6&db=m [Growth and invasion of differentiated thyroid gland carcinoma: importance of signal transduction] causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7761090&form=6&db=m Differential response of the Ras exchange factor, Ras-GRF to tyrosine kinase and G protein mediated signals. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7761186&form=6&db=m Polymerase chain reaction identification of Bordetella pertussis infections in vaccinees and family members in a pertussis vaccine efficacy trial in Germany. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7761266&form=6&db=m Inositol 1,4,5-trisphosphate formation and ryanodine-sensitive oscillations of cytosolic free Ca2+ concentrations in neuroblastoma x fibroblast hybrid NL308 cells expressing m2 and m4 muscarinic acetylcholine receptor subtypes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7762003&form=6&db=m The role of G-proteins in the activation of human leukocytes by particulate stimuli to produce reactive oxygen metabolites. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7762615&form=6&db=m Biphasic regulation of paracellular permeability in human cervical cells by two distinct nucleotide receptors. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7764138&form=6&db=m Immunochemical detection of GTP-binding protein in cephalopod photoreceptors by anti-peptide antibodies. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7764157&form=6&db=m Effect of hydromechanical forces on the production of filamentous haemagglutinin and pertussis toxin of Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7766286&form=6&db=m Alpha-2 adrenoceptors modulate the somatostatinergic system and G protein levels in the rat hippocampus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7766402&form=6&db=m Improved pertussis toxin production by Bordetella pertussis through adjusting the growth medium's ionic composition. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7766894&form=6&db=m Molecular cloning and characterization of RGA1 encoding a G protein alpha subunit from rice (Oryza sativa L. IR-36). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7768328&form=6&db=m Stimulation of glycogenolysis by three locust adipokinetic hormones involves Gs and cAMP. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7768587&form=6&db=m A mutant pertussis toxin molecule that lacks ADP-ribosyltransferase activity, PT-9K/129G, is an effective mucosal adjuvant for intranasally delivered proteins. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7768958&form=6&db=m Distinct tyrosine kinase activation and Triton X-100 insolubility upon Fc gamma RII or Fc gamma RIIIB ligation in human polymorphonuclear leukocytes. Implications for immune complex activation of the respiratory burst. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7769311&form=6&db=m Pertussis infection among adults during the 1993 outbreak in Chicago. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7770100&form=6&db=m Activation of adenosine A1 and bradykinin receptors increases protein kinase C and phospholipase D activity in smooth muscle cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7770101&form=6&db=m Activation of phospholipase C and phospholipase D by stimulation of adenosine A1, bradykinin or P2U receptors does not correlate well with protein kinase C activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7771552&form=6&db=m Electrophysiological effects of alpha 2-adrenergic stimulation in canine cardiac Purkinje fibers. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7771554&form=6&db=m Lysophosphatidic acid alters cerebrovascular reactivity in piglets. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7772233&form=6&db=m Mechanism of action of gamma-aminobutyric acid on frog melanotrophs. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7772346&form=6&db=m Activation of a Gi protein in digitonin/cholate-solubilized membrane preparations of mouse sperm by the zona pellucida, an egg-specific extracellular matrix. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7773535&form=6&db=m Effects of Bordetella pertussis toxin pretreatment on the antiarrhythmic action of ischaemic preconditioning in anaesthetized rats. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7773537&form=6&db=m Pertussis toxin-sensitive muscarinic relaxation in the rat iris dilator muscle. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7774677&form=6&db=m Atrial natriuretic factor stimulates migration by human neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7774679&form=6&db=m Prolonged incubation with neuropeptide Y upregulates beta-adrenoceptors yet does not cause supersensitivity of beta-adrenoceptor signaling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7774680&form=6&db=m Inhibition of voltage-dependent Ca(2+)-current by alpha-adrenoceptor agonists in smooth muscle cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7774686&form=6&db=m Activation of phospholipase C by G-protein beta gamma subunits in DDT1MF-2 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7775387&form=6&db=m The G-protein G(o) in mammalian cardiac muscle: localization and coupling to A1 adenosine receptors. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7775389&form=6&db=m Involvement of pertussis toxin-sensitive mechanism in retinoic acid-induced differentiation of human leukemic HL-60 cells. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7775459&form=6&db=m Stimulation of cannabinoid receptor CB1 induces krox-24 expression in human astrocytoma cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7775628&form=6&db=m Stimulation of intracellular calcium concentration by adenosine triphosphate and uridine 5'-triphosphate in human term placental cells: evidence for purinergic receptors. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7775966&form=6&db=m The Ca2+ influx induced by beta-amyloid peptide 25-35 in cultured hippocampal neurons results from network excitation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7780830&form=6&db=m Heat stress stimulates high affinity GTPase in cervical carcinoma cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7781604&form=6&db=m Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7782277&form=6&db=m A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7782330&form=6&db=m Coupling of human D-1 dopamine receptors to different guanine nucleotide binding proteins. Evidence that D-1 dopamine receptors can couple to both Gs and G(o). therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7784056&form=6&db=m Signalling pathways involved in the mitogenic action of lysophosphatidylinositol. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7784451&form=6&db=m Role of GTP-binding proteins in the polyunsaturated fatty acid stimulated proliferation of mouse mammary epithelial cells. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7785466&form=6&db=m Regulation of parathyroid hormone messenger RNA levels by protein kinase A and C in bovine parathyroid cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7786891&form=6&db=m Characterization of specific subcellular 15-hydroxyeicosatetraenoic acid (15-HETE) binding sites on rat basophilic leukemia cells. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7788877&form=6&db=m Binding of A1 adenosine receptor ligand [3H]8-cyclopentyl-1,3-dipropylxanthine in coronary smooth muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7789506&form=6&db=m Lysophosphatidic acid-induced activation of protein Ser/Thr kinases in cultured rat 3Y1 fibroblasts. Possible involvement in rho p21-mediated signalling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7790385&form=6&db=m Evidence for a pertussis toxin sensitive calcium entry pathway in thyroid FRTL-5 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7791096&form=6&db=m Characterization of anandamide- and fluoroanandamide-induced antinociception and cross-tolerance to delta 9-THC after intrathecal administration to mice: blockade of delta 9-THC-induced antinociception. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7792141&form=6&db=m Arachidonic acid inhibits hormone-stimulated cAMP accumulation in the medullary thick ascending limb of the rat kidney by a mechanism sensitive to pertussis toxin. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7792145&form=6&db=m Enhancement of an L-type calcium current in AtT-20 cells; a novel effect of the m4 muscarinic receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7792294&form=6&db=m Evidence of heterotrimeric G-protein involvement in regulated exocytosis from permeabilized pancreatic acini. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7792803&form=6&db=m Nongenomic aldosterone effects: the cell membrane as a specific target of mineralocorticoid action. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7796869&form=6&db=m Pertussis and cholera toxins modulate kappa-opioid receptor agonists-induced hypothermia and gut inhibition. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7797472&form=6&db=m Platelet-activating factor induces NF-kappa B activation through a G protein-coupled pathway. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7797513&form=6&db=m Factors determining specificity of signal transduction by G-protein-coupled receptors. Regulation of signal transfer from receptor to G-protein. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7798914&form=6&db=m Serotonin 5-HT2C receptor stimulates cyclic GMP formation in choroid plexus. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7803392&form=6&db=m Effect of temperature and host factors on the activities of pertussis toxin and Bordetella adenylate cyclase. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7803518&form=6&db=m U-73122, a phospholipase C antagonist, inhibits effects of endothelin-1 and parathyroid hormone on signal transduction in UMR-106 osteoblastic cells. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7804162&form=6&db=m Use of cyclodextrin as an agent to induce excretion of Bordetella pertussis antigens. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7805400&form=6&db=m Photosensitivity of the isolated pigment epithelium and arachidonic acid metabolism: preliminary results. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7805752&form=6&db=m Induction of natural killer cell migration by monocyte chemotactic protein-1, -2 and -3. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7805756&form=6&db=m Vanadate-induced oscillatory inward Cl- currents in Xenopus laevis oocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7805761&form=6&db=m Potentiation by insulin and insulin-like growth factor-1 of glibenclamide-sensitive K+ currents in follicle-enclosed Xenopus oocytes. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7805768&form=6&db=m The phospholipase C activating P2U purinoceptor also inhibits cyclicAMP formation in DDT1 MF-2 smooth muscle cells. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7806133&form=6&db=m Effect of retinoic acid on prostaglandin F2 alpha-induced prostaglandin E2 synthesis in osteoblast-like cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7806562&form=6&db=m The G protein-activating peptide, mastoparan, and the synthetic NH2-terminal ARF peptide, ARFp13, inhibit in vitro Golgi transport by irreversibly damaging membranes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7810694&form=6&db=m Abnormal regulation of renal proximal tubule Na(+)-K(+)-ATPase by G proteins in spontaneously hypertensive rats. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7810729&form=6&db=m Eicosanoid production by human aortic endothelial cells in response to endothelin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7811458&form=6&db=m Increased levels of active pertussis toxin may aid a pertussis vaccine to pass the mouse body weight gain test. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7812007&form=6&db=m Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils: interleukin-8, but not NAP-2 or GRO alpha, stimulates phospholipase D activity. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7812619&form=6&db=m Antagonism by riluzole of entry of calcium evoked by NMDA and veratridine in rat cultured granule cells: evidence for a dual mechanism of action. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7813557&form=6&db=m Somatostatin-induced inhibition of neurotransmission in the mouse isolated vas deferens is resistant to pertussis toxin. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7813610&form=6&db=m Transforming growth factor-beta 1 has both promoting and inhibiting effects on induction of DNA synthesis in human fibroblasts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7813618&form=6&db=m Analysis of the proliferative response to lysophosphatidic acid in primary cultures of mammary epithelium: differences between normal and tumor cells. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7813624&form=6&db=m Distinct mechanisms for Ca2+ entry induced by OKT3 and Ca2+ depletion in Jurkat T cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7813780&form=6&db=m Involvement of an inhibitory G-protein in the signal transduction pathway of maturation-inducing hormone (17 alpha,20 beta-dihydroxy-4-pregnen-3-one) action in rainbow trout (Oncorhynchus mykiss) oocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7814364&form=6&db=m A heterotrimeric Gi3-protein controls autophagic sequestration in the human colon cancer cell line HT-29. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7814388&form=6&db=m Mannose 6-phosphate/insulin-like growth factor II receptor fails to interact with G-proteins. Analysis of mutant cytoplasmic receptor domains. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7815346&form=6&db=m Modulation of cannabinoid-induced antinociception after intracerebroventricular versus intrathecal administration to mice: possible mechanisms for interaction with morphine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7815347&form=6&db=m Properties of delta opioid receptor in neuroblastoma NS20Y: receptor activation and neuroblastoma proliferation. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7815359&form=6&db=m Characterization of the cloned human mu opioid receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7818984&form=6&db=m Altered guanine nucleoside triphosphate binding to transducin by cholera toxin-catalysed ADP-ribosylation. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7818993&form=6&db=m Effect of prenylcysteine analogues on chemoattractant receptor-mediated G protein activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7821713&form=6&db=m Evidence against roles for pertussis toxin sensitive G proteins or diacylglycerol generation in insulin-like growth factor-1 stimulated DNA synthesis in MG-63 osteosarcoma cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7821721&form=6&db=m G-proteins and adenylyl cyclase in ovarian granulosa cells of amago salmon (Oncorhynchus rhodurus). ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7822164&form=6&db=m Pertussis toxin-sensitive melatonin receptors negatively coupled to adenylate cyclase associated with cultured human and rat retinal pigment epithelial cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7822277&form=6&db=m Conservation of a common motif in enzymes catalyzing ADP-ribose transfer. Identification of domains in mammalian transferases. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7823085&form=6&db=m Modulation of Ca(2+)-channel currents by protein kinase C in adult rat sympathetic neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7823124&form=6&db=m Facilitatory coupling between a glutamate metabotropic receptor and dihydropyridine-sensitive calcium channels in cultured cerebellar granule cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7823158&form=6&db=m Pharmacologically distinct, pertussis toxin-resistant inward currents evoked by metabotropic glutamate receptor (mGluR) agonists in dorsolateral septal nucleus (DLSN) neurons. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7823173&form=6&db=m Endogenous GABA attenuates CNS white matter dysfunction following anoxia. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7823188&form=6&db=m Cortisol inhibition of calcium currents in guinea pig hippocampal CA1 neurons via G-protein-coupled activation of protein kinase C. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7824043&form=6&db=m Receptor crosstalk: effects of prolonged carbachol exposure on beta 1-adrenoceptors and adenylyl cyclase activity in neonatal rat ventricular myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7824190&form=6&db=m Neuroprotective effects of riluzole on N-methyl-D-aspartate- or veratridine-induced neurotoxicity in rat hippocampal slices. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7824528&form=6&db=m Cellular signalling of PGE2 and its selective receptor analogue sulprostone in rabbit cortical collecting duct. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7825832&form=6&db=m Activation of mitogen-activated protein kinase and arachidonate release via two G protein-coupled receptors expressed in the rat hippocampus. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7827022&form=6&db=m ADP-ribosylation of alpha i3C20 by the S1 subunit and deletion peptides of S1 of pertussis toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7828659&form=6&db=m Association of guinea pig lung bombesin receptors with pertussis toxin-sensitive guanine nucleotide binding proteins. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7830057&form=6&db=m Coupling of the human Y2 receptor for neuropeptide Y and peptide YY to guanine nucleotide inhibitory proteins in permeabilized SMS-KAN cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7830559&form=6&db=m Common features of the NAD-binding and catalytic site of ADP-ribosylating toxins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7834216&form=6&db=m Muscarinic (M1) receptor-mediated inhibition of K(+)-evoked [3H]-noradrenaline release from human neuroblastoma (SH-SY5Y) cells via inhibition of L- and N-type Ca2+ channels. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7834817&form=6&db=m Activation of phosphoinositide-specific phospholipase C of rat neutrophils by the chemotactic aldehydes 4-hydroxy-2,3-trans-nonenal and 4-hydroxy-2,3-trans-octenal. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7834835&form=6&db=m Adenosine A2a and A2b receptors in cultured fetal chick heart cells. High- and low-affinity coupling to stimulation of myocyte contractility and cAMP accumulation. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7835309&form=6&db=m Cooperation of thyrotropin, but not basic fibroblast growth factor, with an adenosine receptor agonist in Ca2+ mobilization from thapsigargin-sensitive pools in single FRTL-5 thyroid cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7835644&form=6&db=m Pertussis toxin prevents neomycin-induced calcium-dependent electrophysiological effects in rat hippocampal slices. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7840157&form=6&db=m Modulation of the delayed rectifier K+ current in neurons by an angiotensin II type 2 receptor fragment. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7840171&form=6&db=m Growth responses to angiotensin II in bovine adrenal glomerulosa cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7840211&form=6&db=m Phenylalanine-stimulated secretion of cholecystokinin is calcium dependent. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7840320&form=6&db=m Regulation of NPY/NPY Y1 receptor/G protein system in rat brain cortex. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7841355&form=6&db=m Interleukin-13 is a monocyte chemoattractant. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7842473&form=6&db=m Effects of the amphiphilic peptides mastoparan and adenoregulin on receptor binding, G proteins, phosphoinositide breakdown, cyclic AMP generation, and calcium influx. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7843128&form=6&db=m Effects of organometals on cellular signaling. I. Influence of metabolic inhibitors on metal-induced arachidonic acid liberation. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7843729&form=6&db=m Endothelin stimulates platelet-activating factor synthesis by cultured rat Kupffer cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7847435&form=6&db=m Increase of myocardial inhibitory G-proteins in catecholamine-refractory septic shock or in septic multiorgan failure. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7848283&form=6&db=m Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7851943&form=6&db=m A mechanistic approach into a diabetic serum factor-mediated release of beta-glucuronidase in normal neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7853195&form=6&db=m Pertussis toxin attenuates presynaptic inhibition of cholinergic but not nonadrenergic noncholinergic contraction in guinea pig airways. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7854346&form=6&db=m The somatostatin receptor SSTR1 is coupled to phosphotyrosine phosphatase activity in CHO-K1 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7856288&form=6&db=m Enhancing effects of pertussis toxin B oligomer on the immunogenicity of influenza vaccine administered intranasally. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7857647&form=6&db=m Bradykinin excites rat sympathetic neurons by inhibition of M current through a mechanism involving B2 receptors and G alpha q/11. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7857771&form=6&db=m The GTP-binding protein Gi alpha 2 is directly linked to and substrate of a serine kinase in Balb/c3T3 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7857772&form=6&db=m Insulin-stimulated phosphatidylcholine hydrolysis, diacylglycerol/protein kinase C signalling, and hexose transport in pertussis toxin-treated BC3H-1 myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7858845&form=6&db=m Paired-pulse depression of the N-methyl-D-aspartate receptor-mediated synaptic potentials in the amygdala. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7859105&form=6&db=m Noradrenergic modulation of synaptic transmission between olfactory bulb neurons in culture: implications to olfactory learning. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7859920&form=6&db=m Regulation of heat-shock protein (hsp70) gene expression by hGH and IL2 in rat Nb2 lymphoma cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7859925&form=6&db=m Effect of endothelin-1 on phospholipase D activity in osteoblast-like cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7861141&form=6&db=m Pertussis toxin-sensitive G protein alpha-subunits: production of monoclonal antibodies and detection of differential increases on differentiation of PC12 and LA-N-5 cells. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7862259&form=6&db=m Pertussis toxin pretreatment enhances catecholamine secretion induced by pituitary adenylate cyclase-activating polypeptide in cultured porcine adrenal medullary chromaffin cells: a possible role of the inositol lipid cascade. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7862737&form=6&db=m Spinal and supraspinal effects of pertussis toxin on opioid analgesia. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7864073&form=6&db=m G protein-mediated suppression of L-type Ca2+ current by interleukin-1 beta in cultured rat ventricular myocytes. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7864143&form=6&db=m Role of G proteins and KCa channels in the muscarinic and beta-adrenergic regulation of airway smooth muscle. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7864172&form=6&db=m cAMP modulates transepithelial resistance response of LLC-PK1 renal epithelia to tumor necrosis factor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7864174&form=6&db=m Pathways involved in PTH-induced rise in cytosolic Ca2+ concentration of rat renal proximal tubule. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7865171&form=6&db=m Reduced concentrations of the alpha-subunit of GTP-binding protein Go in schizophrenic brain. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7865172&form=6&db=m Effect of pertussis toxin on the response of rat medial prefrontal cortex cells to the iontophoresis of serotonin receptor agonists. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7867605&form=6&db=m Hormonal regulation of mitogen-activated protein kinase activity in bovine adrenocortical cells: cross-talk between phosphoinositides, adenosine 3',5'-monophosphate, and tyrosine kinase receptor pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7868253&form=6&db=m Pertussis toxin-mediated ADP-ribosylation of target proteins in Chinese hamster ovary cells involves a vesicle trafficking mechanism. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7869241&form=6&db=m Inhibition of inwardly rectifying K+ current by external Ca2+ ions in freshly isolated rabbit osteoclasts. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7870030&form=6&db=m The class III antiarrhythmic drug amiodarone directly activates pertussis toxin-sensitive G proteins. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7870040&form=6&db=m Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7870285&form=6&db=m Modification of cysteine residues within G(o) and other neuronal proteins by exposure to nitric oxide. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7875310&form=6&db=m Gz coupling to the rat kappa-opioid receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7875744&form=6&db=m Regulation of DTH and IgE responses by IL-4 and IFN-gamma in immunized mice given pertussis toxin. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7876081&form=6&db=m Alpha 2 adrenergic receptor subtypes expressed in Chinese hamster ovary cells activate differentially mitogen-activated protein kinase by a p21ras independent pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7876108&form=6&db=m Stimulation of mitogen-activated protein kinase by thyrotropin in primary cultured human thyroid follicles. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7876152&form=6&db=m Functional analysis of a dominant negative mutant of G alpha i2. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7876204&form=6&db=m Angiotensin II stimulates tyrosine phosphorylation of the focal adhesion-associated protein paxillin in aortic smooth muscle cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7876333&form=6&db=m Cytosolic phospholipase C activity: I. Evidence for coupling with cytosolic guanine nucleotide-binding protein, Gi alpha. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7876829&form=6&db=m Differential effects of pertussis toxin on the muscarinic regulation of Ca2+ and K+ currents in frog cardiac myocytes. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7877138&form=6&db=m Sarafotoxin-induced calcium mobilization in cultured dog tracheal smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7877599&form=6&db=m Signal transduction pathways of muscarinic receptors in circular smooth muscle from the rabbit caecum. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7878084&form=6&db=m Generation of inositol phosphates in bitter taste transduction. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7879693&form=6&db=m [Ca2+]i-transients and actin polymerization in human neutrophils under stimulation with GRO alpha and complement fragment C5a. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7882571&form=6&db=m Co-stimulation of T cells via CD28 inhibits human IgE production; reversal by pertussis toxin. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7882998&form=6&db=m Stimulation of mitogen-activated protein kinase by thyrotropin in astrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7883021&form=6&db=m Reduction of in vivo striatal 5-hydroxytryptamine release by 8-OH-DPAT after inactivation of Gi/G(o) proteins in dorsal raphe nucleus. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7883040&form=6&db=m Epidermal growth factor stimulates hydrolysis of phosphatidylinositol 4,5-bisphosphate, generation of diacylglycerol and exocytosis in mouse spermatozoa. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7884323&form=6&db=m TNF-alpha stimulates increased plasma membrane guanine nucleotide binding protein activity in polymorphonuclear leukocytes. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7884461&form=6&db=m Differences between presynaptic and postsynaptic GABAB mechanisms in rat hippocampal pyramidal cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7887933&form=6&db=m The human chemoattractant complement C5a receptor inhibits cyclic AMP accumulation through Gi and Gz proteins. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7888169&form=6&db=m Calcium influx into mouse spermatozoa activated by solubilized mouse zona pellucida, monitored with the calcium fluorescent indicator, fluo-3. Inhibition of the influx by three inhibitors of the zona pellucida induced acrosome reaction: tyrphostin A48, pertussis toxin, and 3-quinuclidinyl benzilate. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7888304&form=6&db=m Evidence for expression of a Ras-like and a stage specific GTP binding homologous protein by Plasmodium falciparum. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7889122&form=6&db=m Cholera toxin can ADP-ribosylate Gs as well as Gi in ACTH-unresponsive human adrenocortical cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7890042&form=6&db=m kappa-Opioid receptor-transfected cell lines: modulation of adenylyl cyclase activity following acute and chronic opioid treatments. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7890708&form=6&db=m Signal transduction and ligand specificity of the human monocyte chemoattractant protein-1 receptor in transfected embryonic kidney cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7891089&form=6&db=m Inhibition of adenylyl cyclase activity by a homogeneous population of dopamine receptors: selective blockade by antisera directed against Gi1 and/or Gi2. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7891120&form=6&db=m 5-Methoxytryptamine inhibits cyclic AMP accumulation in cultured retinal neurons through activation of a pertussis toxin-sensitive site distinct from the 2-[125I]iodomelatonin binding site. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7891554&form=6&db=m Common ancestry between IncN conjugal transfer genes and macromolecular export systems of plant and animal pathogens. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7891778&form=6&db=m Heat-aggregated IgA prepared from patients with IgA nephropathy increases priming of human neutrophils to produce inositol triphosphate following FMet-Leu-Phe stimulation in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7892108&form=6&db=m Activation of nucleotide receptors inhibits M-type K current [IK(M)] in neuroblastoma x glioma hybrid cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7893491&form=6&db=m Solubilization and partial purification from mouse sperm membranes of the specific binding activity for 3-quinuclidinyl benzilate, a potent inhibitor of the zona pellucida-induced acrosome reaction. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7895245&form=6&db=m The combined 5-HT2 receptor and calcium channel inhibitor LU49938 restores endothelium dependent responses in the regenerated endothelium of the porcine coronary artery. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7895337&form=6&db=m Acetylcholine elicits a rebound stimulation of Ca2+ current mediated by pertussis toxin-sensitive G protein and cAMP-dependent protein kinase A in atrial myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7895841&form=6&db=m Trypanosoma brucei: characterisation of a life cycle stage-specific G-protein. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7895913&form=6&db=m Inhibition of human thyroid adenylyl cyclase by 2-iodoaldehydes. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7897700&form=6&db=m Role of GABAB receptors in intracellular Ca2+ homeostasis and possible interaction between GABAA and GABAB receptors in regulation of transmitter release in cerebellar granule neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7897789&form=6&db=m Pertussis infection in adults with persistent cough. diagnostic usage,ongoing research,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7898309&form=6&db=m Mobilization of intracellular Ca2+ and stimulation of cyclic AMP production by kappa opioid receptors expressed in Xenopus oocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7898456&form=6&db=m Characterization of botulinum C3-catalyzed ADP-ribosylation of rho proteins and identification of mammalian C3-like ADP-ribosyltransferase. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7898467&form=6&db=m Enzymatic and nonenzymatic ADP-ribosylation of cysteine. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7898487&form=6&db=m Alterations in G-proteins in congestive heart failure in cardiomyopathic (UM-X7.1) hamsters. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7900764&form=6&db=m Aldosterone stimulation of GTP hydrolysis in membranes from renal epithelia. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7900823&form=6&db=m The role of protein kinase C in alpha-adrenergic regulation of NaCl(K) cotransport in human airway epithelial cells. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7900846&form=6&db=m Regulation of renal cortical Na-HCO3 cotransporter. II. Role of G proteins. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7901213&form=6&db=m Evidence for a catalytic role of glutamic acid 129 in the NAD-glycohydrolase activity of the pertussis toxin S1 subunit. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7902295&form=6&db=m Inversion of Ca2+ current modulation during recovery of neuroblastoma cells from pertussis toxin pretreatment. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7902522&form=6&db=m Gx/z and Gi2 transducer proteins on mu/delta opioid-mediated supraspinal antinociception. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7902868&form=6&db=m Activation of a common potassium channel in molluscan neurones by glutamate, dopamine and muscarinic agonist. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7903393&form=6&db=m D2 dopamine receptor stimulation of mitogenesis in transfected Chinese hamster ovary cells: relationship to dopamine stimulation of tyrosine phosphorylations. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7903931&form=6&db=m Relative potencies of the somatostatin analogs octreotide, BIM-23014, and RC-160 on the inhibition of hormone release by cultured human endocrine tumor cells and normal rat anterior pituitary cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7904056&form=6&db=m Bromocriptine, a dopamine D2 receptor agonist, inhibits adenylyl cyclase activity in rat olfactory epithelium. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7904711&form=6&db=m Adenosine 5'-triphosphate, phorbol ester, and pertussis toxin effects on atrial natriuretic peptide stimulation of guanylate cyclase in a human renal cell line. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7905265&form=6&db=m All five cloned human somatostatin receptors (hSSTR1-5) are functionally coupled to adenylyl cyclase. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7905527&form=6&db=m Activation of alpha-1A adrenoceptors mobilizes calcium from the intracellular stores in myocytes from rat portal vein. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7905811&form=6&db=m Characterization of the alpha 1B-adrenergic receptors of chicken hepatocytes. Signal transduction and actions. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7907016&form=6&db=m The somatostatin receptors SSTR1 and SSTR2 are coupled to inhibition of adenylyl cyclase in Chinese hamster ovary cells via pertussis toxin-sensitive pathways. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7907280&form=6&db=m Platelet-activating factor: a putative neuromodulator and mediator in the pathophysiology of brain injury. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7907363&form=6&db=m Functional expression and characterization of human D2 and D3 dopamine receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7907511&form=6&db=m The phorbol ester TPA potentiates cholera toxin- and isoproterenol-stimulated cyclic AMP-synthesis in primary astrocyte cultures. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7907519&form=6&db=m Rapid desensitization of the metabotropic glutamate receptor that facilitates glutamate release in rat cerebrocortical nerve terminals. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7907603&form=6&db=m Neutrophil recruitment in Clostridium difficile toxin A enteritis in the rabbit. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7908169&form=6&db=m Activation of PtdIns(4,5)P2-sensitive phospholipase C in rabbit tracheal epithelial cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7908252&form=6&db=m Effects of pertussis and cholera toxins on alpha-adrenoceptor function in rat tail artery: differences in hypertension. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7908588&form=6&db=m Effects of pertussis and cholera toxin on the interferon-gamma stimulated immunocytochemical staining of ICAM-1 and inositol phosphate formation in a human renal carcinoma cell line. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7908723&form=6&db=m (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid attenuates N-methyl-D-aspartate-induced neuronal cell death in cortical cultures via a reduction in delayed Ca2+ accumulation. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7908748&form=6&db=m Pertussis toxin-sensitive airway beta-adrenergic dysfunction by somatostatin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7908861&form=6&db=m Receptor-effector coupling pathway for alpha 1-adrenergic modulation of abnormal automaticity in 'ischemic' canine Purkinje fibers. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7908883&form=6&db=m Coupling of human alpha 2-adrenoceptor subtypes to regulation of cAMP production in transfected S115 cells. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7908917&form=6&db=m Pertussis toxin interferes with superantigen-induced deletion of peripheral T cells without affecting T cell activation in vivo. Inhibition of deletion and associated programmed cell death depends on ADP-ribosyltransferase activity. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7908944&form=6&db=m An ibotenate-selective metabotropic glutamate receptor mediates protein phosphorylation in cultured hippocampal pyramidal neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7909407&form=6&db=m Activation of G protein-coupled K+ channels by dopamine in human GH-producing cells. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7910018&form=6&db=m Transfected human somatostatin receptor type 2, SSTR2, not only inhibits adenylate cyclase but also stimulates phospholipase C and Ca2+ mobilization. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7910371&form=6&db=m Contribution of ligand structure to activation of alpha 2-adrenergic receptor subtype coupling to Gs. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7910658&form=6&db=m The D2S and D2L dopamine receptor isoforms are differentially regulated in Chinese hamster ovary cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7910677&form=6&db=m Cycloheximide abolishes pertussis toxin-induced increase in glutamate release from cerebellar granule neurones. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7911063&form=6&db=m Nicotinic and muscarinic acetylcholine responses in differentiated PC12 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7911302&form=6&db=m Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7911712&form=6&db=m Functional expression of human D3 dopamine receptors in differentiated neuroblastoma x glioma NG108-15 cells. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7911806&form=6&db=m Pertussis toxin inhibition of T-cell hybridoma invasion is reversed by manganese-induced activation of LFA-1. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7911830&form=6&db=m Metabotropic glutamate response in acutely dissociated hippocampal CA1 pyramidal neurones of the rat. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7912604&form=6&db=m Inhibitory action of somatostatin on cAMP dependent pepsinogen secretion from rat gastric chief cells: involvement of pertussis toxin-sensitive G-protein. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7912731&form=6&db=m Melanostatin (NPY) inhibited electrical activity in frog melanotrophs through modulation of K+, Na+ and Ca2+ currents. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7913124&form=6&db=m D1 agonist-induced excitation of substantia nigra pars reticulata neurons: mediation by D1 receptors on striatonigral terminals via a pertussis toxin-sensitive coupling pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7914838&form=6&db=m Pertussis toxin-sensitive G protein mediates coronary microvascular control during autoregulation and ischemia in canine heart. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7915334&form=6&db=m Enhanced negative inotropic effect of an adenosine A1-receptor agonist in rat left atria in hypothyroidism. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7915496&form=6&db=m Molecular basis for somatostatin action: inhibition of c-fos expression and AP-1 binding. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7916015&form=6&db=m The D2 dopamine receptor isoforms signal through distinct Gi alpha proteins to inhibit adenylyl cyclase. A study with site-directed mutant Gi alpha proteins. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7916348&form=6&db=m Pancreastatin activates pertussis toxin-sensitive guanylate cyclase and pertussis toxin-insensitive phospholipase C in rat liver membranes. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7916442&form=6&db=m Peptides from pertussis toxin interfere with neutrophil adherence in vitro and counteract inflammation in vivo. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7917296&form=6&db=m VIP inhibits N-type Ca2+ channels of sympathetic neurons via a pertussis toxin-insensitive but cholera toxin-sensitive pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7917299&form=6&db=m Glutamate activates a K+ conductance increase in Aplysia neurons that appears to be independent of G proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7918354&form=6&db=m Ligand-specific stimulation/inhibition of cAMP formation by a novel endothelin receptor subtype. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7919350&form=6&db=m Structural requirements of platelet chemokines for neutrophil activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7920030&form=6&db=m Adjuvant effect of pertussis toxin on the production of anti-ovalbumin IgE in mice and lack of direct correlation between PCA and ELISA. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7921603&form=6&db=m The effect of cyclic AMP elevating agents on bradykinin- and carbachol-induced signal transduction in canine cultured tracheal smooth muscle cells. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7921629&form=6&db=m Potentiation by adenosine of ATP-evoked dopamine release via a pertussis toxin-sensitive mechanism in rat phaeochromocytoma PC12 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7921782&form=6&db=m Effect of 12-hydroxyeicosatetraenoic acid on cytosolic calcium in human neutrophils. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7922580&form=6&db=m D2 inhibition of stimulated Fos immunoreactivity in cultured tyrosine hydroxylase-ir hypothalamic neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7923618&form=6&db=m Mechanisms for vagal modulation of ventricular repolarization and of coronary occlusion-induced lethal arrhythmias in cats. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7923680&form=6&db=m Mitogenic effect of serotonin on vascular endothelial cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7925125&form=6&db=m Neuropeptide Y stimulates luteinizing hormone-releasing hormone release from superfused hypothalamic GT1-7 cells. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7925712&form=6&db=m Alpha-2 adrenoceptor mediated changes in aqueous dynamics: effect of pertussis toxin. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7926274&form=6&db=m Ontogeny of the inhibitory guanine nucleotide-binding regulatory protein in the rat testis: mRNA expression and modulation of LH and FSH action. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7926371&form=6&db=m Monocyte chemotactic proteins MCP-1, MCP-2, and MCP-3 are major attractants for human CD4+ and CD8+ T lymphocytes. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7927648&form=6&db=m Glial receptors and their intervention in astrocyto-astrocytic and astrocyto-neuronal interactions. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7927673&form=6&db=m Importance of ADP-ribosylation in the morphological changes of PC12 cells induced by cholera toxin. causal interaction,ongoing research,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7929124&form=6&db=m Evidence for participation of calcineurin in potentiation of agonist-stimulated cyclic AMP formation by the calcium-mobilizing hormone, angiotensin II. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7929127&form=6&db=m Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7929847&form=6&db=m The expression and function of G-proteins in experimental intimal hyperplasia. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7930588&form=6&db=m Activation of human monocytes via a non-neurokinin substance P receptor that is coupled to Gi protein, calcium, phospholipase D, MAP kinase, and IL-6 production. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7930624&form=6&db=m Thrombospondin promotes chemotaxis and haptotaxis of human peripheral blood monocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7931326&form=6&db=m Platelet-activating factor: diminished acetylcholine release from rat brain slices is mediated by a Gi protein. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7931548&form=6&db=m Opioids inhibit endothelin-mediated DNA synthesis, phosphoinositide turnover, and Ca2+ mobilization in rat C6 glioma cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7931576&form=6&db=m Inactivation of Gi and G(o) proteins in nucleus accumbens reduces both cocaine and heroin reinforcement. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7932150&form=6&db=m Endothelin ETB receptors couple to two distinct signaling pathways in porcine kidney epithelial LLC-PK1 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7932382&form=6&db=m Functional platelet-activating factor receptors linked to inositol lipid hydrolysis, calcium mobilization and tyrosine kinase activity in the human endometrial HEC-1B cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7932796&form=6&db=m Histamine-induced microvascular leakage in pial venules: differences between the SJL/J and BALB/c inbred strains of mice. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7933847&form=6&db=m PDGF-mediated activation of phosphatidylinositol 3 kinase in human mesangial cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7934972&form=6&db=m Acute stress-induced hyperinsulinemia in the pertussis toxin-treated rat: possible role of humoral beta-cell-tropic factors. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7935329&form=6&db=m Endothelin receptor type A signals both the accumulation of inositol phosphates and the inhibition of cyclic AMP generation in rat myometrium: stimulation and desensitization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7935854&form=6&db=m A1 adenosine receptors expressed in CHO-cells couple to adenylyl cyclase and to phospholipase C. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7936112&form=6&db=m Effect of sulpiride on somatostatin receptors, somatostatin-like immunoreactivity and modulation of adenylyl cyclase activity in the rat brain. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7943201&form=6&db=m Identification of A1 adenosine receptors in rat cochlea coupled to inhibition of adenylyl cyclase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7943204&form=6&db=m Role of G proteins in shear stress-mediated nitric oxide production by endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7943256&form=6&db=m Adrenergic receptor-mediated regulation of cultured rabbit airway smooth muscle cell proliferation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7943317&form=6&db=m Regulation of PI hydrolysis and cAMP formation by muscarinic M3 receptor in guinea pig gallbladder. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7943663&form=6&db=m Role of the GTP-binding protein G(o) in the suppressant effect of ethanol on voltage-activated calcium channels of murine sensory neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7943843&form=6&db=m Halothane inhibits bradykinin-stimulated prostacyclin production in endothelial cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7945220&form=6&db=m The palmitoylation status of the G-protein G(o)1 alpha regulates its activity of interaction with the plasma membrane. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7945264&form=6&db=m Pancreastatin activates protein kinase C by stimulating the formation of 1,2-diacylglycerol in rat hepatocytes. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7945265&form=6&db=m Lysophosphatidic acid activation of phosphatidylcholine-hydrolysing phospholipase D and actin polymerization by a pertussis toxin-sensitive mechanism. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7945328&form=6&db=m Possible involvement of GTP-binding proteins in 1 alpha,25-dihydroxyvitamin D3 induction of tissue transglutaminase in mouse peritoneal macrophages. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7945376&form=6&db=m Mouse prostaglandin E receptor EP3 subtype mediates calcium signals via Gi in cDNA-transfected Chinese hamster ovary cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7946271&form=6&db=m Immunoelectron microscopy of antigens of Bordetella pertussis using monoclonal antibodies to agglutinogens 2 and 3, filamentous haemagglutinin, pertussis toxin, pertactin and adenylate cyclase toxin. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7946358&form=6&db=m The G protein G13 mediates inhibition of voltage-dependent calcium current by bradykinin. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7946966&form=6&db=m Enhanced cyclic AMP responses in GH3 pituitary cells pretreated with muscarinic receptor agonists. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7946969&form=6&db=m Differential interaction of beta 1- and beta 3-adrenergic receptors with Gi in rat adipocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7947403&form=6&db=m Vasoactive intestinal polypeptide modulates GABAA receptor function through activation of cyclic AMP. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7948421&form=6&db=m [Hormone-like action of blood plasma lipoproteins on human platelets and smooth vascular muscle cells] ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7949145&form=6&db=m Activation of phospholipase D by interleukin-8 in human neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7952877&form=6&db=m Muscarinic acetylcholine response in pyramidal neurones of rat cerebral cortex. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7955338&form=6&db=m Somatostatin enhances nerve growth factor-induced neurite outgrowth in PC12 cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7956118&form=6&db=m Regulation of the CHAPS-solubilized muscarinic receptors by an inhibitory GTP binding protein (Gi) in the brain of neonatal and adult rats. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7956944&form=6&db=m Gonadotropin-releasing hormone (GnRH)-receptor coupling to inositol phosphate and prolactin production in GH3 cells stably transfected with rat GnRH receptor complementary deoxyribonucleic acid. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7957264&form=6&db=m Role of pertussis toxin in causing symptoms of Bordetella parapertussis infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7957635&form=6&db=m Functional coupling of the human dopamine D3 receptor in a transfected NG 108-15 neuroblastoma-glioma hybrid cell line. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7958204&form=6&db=m The inhibition of stimulus-secretion coupling in pancreatic islets by volatile anaesthetics does not involve pertussis toxin sensitive G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7958741&form=6&db=m Enhancement of the positive inotropic effect mediated by alpha 1-adrenoceptors in pertussis toxin-treated rabbit papillary muscles. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7958858&form=6&db=m Ras/MAP kinase-dependent and -independent signaling pathways target distinct ternary complex factors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7959600&form=6&db=m [Pharmacological characterization of alpha 2-adrenoceptor regulated 5-HT release in the rat hippocampus] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7961498&form=6&db=m Effect of mutations causing overexpression of RNA polymerase alpha subunit on regulation of virulence factors in Bordetella pertussis. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7961850&form=6&db=m Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7961926&form=6&db=m Activation by chemotactic peptide of a receptor-operated Ca2+ entry pathway in differentiated HL60 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7961942&form=6&db=m Heterotrimeric G proteins containing G alpha i3 regulate multiple effector enzymes in the same cell. Activation of phospholipases C and A2 and inhibition of adenylyl cyclase. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7962102&form=6&db=m Ca2+ influx and neurite growth in response to purified N-cadherin and laminin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7962103&form=6&db=m Slow oscillations of free intracellular calcium ion concentration in human fibroblasts responding to mechanical stretch. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7962170&form=6&db=m Prostaglandin F2 alpha activates phospholipase D independently from activation of protein kinase C in osteoblast-like cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7963069&form=6&db=m Platelet pertussis toxin-sensitive G proteins in affective disorders. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7964129&form=6&db=m LDL increases (CA++)i in human endothelial cells and augments thrombin-induced cell signalling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7964131&form=6&db=m Changes of cytosolic calcium ion concentrations in human endothelial cells in response to thrombin, platelet-activating factor, and leukotriene B4. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7964288&form=6&db=m Mastoparan, a wasp venom peptide, stimulates release of prolactin from cultured rat anterior pituitary cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7964726&form=6&db=m Tryptamine induces phosphoinositide turnover and modulates adrenergic and muscarinic cholinergic receptor function in cultured cerebellar granule cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7965024&form=6&db=m Glutamate metabotropic receptor inhibition of voltage-gated calcium currents in visceral sensory neurons. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7965099&form=6&db=m The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7965106&form=6&db=m Dual effects of angiotensin II on calcium currents in neonatal rat nodose neurons. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7965758&form=6&db=m Neuropeptide Y inhibition of nicotinic receptor-mediated chromaffin cell secretion. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7965766&form=6&db=m Pertussis toxin blocks M2 muscarinic receptor-mediated effects on contraction and cyclic AMP in the guinea pig ileum, but not M3-mediated contractions and phosphoinositide hydrolysis. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7965773&form=6&db=m m-chlorophenylpiperazine and m-trifluoromethylphenylpiperazine are partial agonists at cloned 5-HT2A receptors expressed in fibroblasts. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7965816&form=6&db=m L-channel modulation by alpha-1 adrenoceptor activation in neonatal rat ventricular cells: intracellular mechanisms. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7966244&form=6&db=m Regulation by GTP of a Ca(2+)-activated K+ channel in the apical membrane of rabbit cortical collecting duct cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7968256&form=6&db=m Antibodies directed against alpha subunits of Gi, Gx/z, GO and GS transducer proteins reduced the morphine withdrawal syndrome in mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7969042&form=6&db=m Kinetics and reversibility of thyrotropin-releasing hormone-stimulated guanine nucleotide exchange in membranes from GH4C1 cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7969064&form=6&db=m Nucleotide-independent modulation of Ca(2+)-dependent K+ channel current by a mu-type opioid receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7969069&form=6&db=m Coupling of the C5a receptor to Gi in U-937 cells and in cells transfected with C5a receptor cDNA. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7969510&form=6&db=m Effects of intrathecal or intracerebroventricular pretreatment with pertussis toxin on antinociception induced by beta-endorphin or morphine administered intracerebroventricularly in mice. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7969818&form=6&db=m Neuropeptide Y inhibits vasoactive intestinal peptide-stimulated adenylyl cyclase in rat ventral prostate. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7969892&form=6&db=m Agonist occupation of serotonin1A receptors in the rat hippocampus prevents their inactivation by pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7971157&form=6&db=m Different G proteins are involved in the biphasic response of clonal rat pituitary cells to thyrotropin-releasing hormone. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7971166&form=6&db=m Isoproterenol modulates the calcium channels through two different mechanisms in smooth-muscle cells from rabbit portal vein. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7976521&form=6&db=m Mechanisms of glutamate induced swelling in astroglial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7977683&form=6&db=m Muscarinic stimulation of gallbladder epithelium. III. Antagonism of cAMP-mediated effects. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7977700&form=6&db=m Angiotensin II type 2 receptor stimulation of neuronal K+ currents involves an inhibitory GTP binding protein. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7977702&form=6&db=m Effects of prostaglandin E2 on amiloride-blockable Na+ channels in a distal nephron cell line (A6). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7977735&form=6&db=m Pertussis toxin stimulates hypersensitivity and enhances nerve-mediated antigen uptake in rat intestine. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7977736&form=6&db=m Mechanisms of PTH-induced rise in cytosolic calcium in adult rat hepatocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7977744&form=6&db=m Multiple actions of epidermal growth factor and TGF-alpha on rabbit gastric parietal cell function. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7979823&form=6&db=m N-ethylmaleimide increases the L-type calcium current in guinea-pig ventricular myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7980392&form=6&db=m Evidence from studies with hepatocyte suspensions that store-operated Ca2+ inflow requires a pertussis toxin-sensitive trimeric G-protein. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7980589&form=6&db=m Adenosine induces C1- efflux in endothelial cells via a pertussis toxin-sensitive G protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7980611&form=6&db=m Endothelin-1 activates mitogen-activated protein kinases through two independent signalling pathways in rat astrocytes. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7981210&form=6&db=m Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7981246&form=6&db=m Possible involvement of phosphatidylinositol-specific phospholipase C related to pertussis toxin-sensitive GTP-binding proteins during adipocyte differentiation of 3T3-L1 fibroblasts: negative regulation of protein kinase C. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7981632&form=6&db=m Glutamate stimulates the phosphorylation of glial fibrillary acidic protein in slices of immature rat hippocampus via a metabotropic receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7981634&form=6&db=m Is the heterologous expression of metabotropic glutamate receptors (mGluRs) an appropriate method to study the mGluR function? Experience with human embryonic kidney 293 cells transfected with mGluR1. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7982455&form=6&db=m Effects of chronic receptor blockade on excitation-contraction coupling in rat aortic rings. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7982897&form=6&db=m Expression and characterization of the bovine histamine H1 receptor in cDNA-transfected C6 astroglioma cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7982904&form=6&db=m Retinoic acid-induced gene expression of tissue transglutaminase via protein kinase C-dependent pathway in mouse peritoneal macrophages. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7982922&form=6&db=m Differential coupling of G protein alpha subunits to seven-helix receptors expressed in Xenopus oocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7982935&form=6&db=m Alpha 2-adrenergic stimulation promotes preadipocyte proliferation. Involvement of mitogen-activated protein kinases. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7983652&form=6&db=m Experimental arthritis and uveitis in rats associated with Mycobacterium butyricum. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7984278&form=6&db=m The cloned human 5-HT1E receptor couples to inhibition and activation of adenylyl cyclase via two distinct pathways in transfected BS-C-1 cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7984978&form=6&db=m Effect of erythromycin treatment on antibody responses in pertussis. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7986196&form=6&db=m Differential activation of dibutyryl cAMP-differentiated HL-60 human leukemia cells by chemoattractants. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7986201&form=6&db=m Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7987376&form=6&db=m Cellular distribution of G protein Go alpha in pituitary lactotrophs: effects of dopamine. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7987686&form=6&db=m Glutamate elicits an outward K+ current which is normally suppressed by a Ca2+/calmodulin-dependent protein kinase II. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7988431&form=6&db=m Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7989119&form=6&db=m Identification and characterization of autocrine-motility-factor-like activity in oral squamous-cell-carcinoma cells. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7989321&form=6&db=m Dual pathways for GTP-dependent regulation of chemoattractant-activated K+ conductance in murine J774 monocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7989602&form=6&db=m Evidence for deactivation of both ectosolic and cytosolic 5'-nucleotidase by adenosine A1 receptor activation in the rat cardiomyocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7991631&form=6&db=m Modulation of brain Na+ channels by a G-protein-coupled pathway. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7992198&form=6&db=m Dopamine neuron membrane physiology: characterization of the transient outward current (IA) and demonstration of a common signal transduction pathway for IA and IK. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7993636&form=6&db=m Depolarization-induced suppression of GABAergic inhibition in rat hippocampal pyramidal cells: G protein involvement in a presynaptic mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7994027&form=6&db=m Changes in G protein pattern and in G protein-dependent signaling during erythropoietin- and dimethylsulfoxide-induced differentiation of murine erythroleukemia cells. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7994562&form=6&db=m Pertussis toxin pretreatment alters agonist binding to beta-adrenoceptors in rabbit ventricular myocardium. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7996466&form=6&db=m Precoupling of alpha-2B adrenergic receptors and G-proteins in transfected PC-12 cell membranes: influence of pertussis toxin and a lysine-directed cross-linker. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7996473&form=6&db=m Characterization of PD 121981- and CGP 42112-induced unmasking of low concentration effects of angiotensin II in rabbit abdominal aorta. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7996485&form=6&db=m Analysis of delta-opioid receptor activities stably expressed in CHO cell lines: function of receptor density? causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7996489&form=6&db=m Alteration of G protein levels in antigen-challenged guinea pigs. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7998971&form=6&db=m Mastoparan may activate GTP hydrolysis by Gi-proteins in HL-60 membranes indirectly through interaction with nucleoside diphosphate kinase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7999020&form=6&db=m On the mechanism of cytosolic phospholipase A2 activation in CHO cells carrying somatostatin receptor: wortmannin-sensitive pathway to activate mitogen-activated protein kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7999145&form=6&db=m Characterization of murine lung inflammation after infection with parental Bordetella pertussis and mutants deficient in adhesins or toxins. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8000707&form=6&db=m TNF alpha-induced activation of eosinophil oxidative metabolism and morphology--comparison with IL-5. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8001631&form=6&db=m In vitro studies on responses to pentoxifylline and aminophylline of rat mesenteric resistance vessels. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8002943&form=6&db=m Purification of a novel G-protein alpha 0-subtype from mammalian brain. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8002980&form=6&db=m Adenosine acts as an endogenous activator of the cellular antioxidant defense system. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8004055&form=6&db=m Efficient production of active and mutated ADP-ribosyltransferase (S1) of pertussis toxin using affinity expression cassette polymerase chain reaction. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8004062&form=6&db=m Stimulation of reactive oxidant production in neutrophils by soluble and insoluble immune complexes occurs via different receptors/signal transduction systems. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8004064&form=6&db=m Effect of lysophosphatidic acid on motility, polarisation and metabolic burst of human neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8004444&form=6&db=m Differential regulation of glutamate decarboxylase and preproenkephalin mRNA levels in the rat striatum. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8006586&form=6&db=m Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8006975&form=6&db=m Radioimmunochemical quantification of Gi alpha in right and left ventricles from patients with ischaemic and dilated cardiomyopathy and predominant left ventricular failure. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8007454&form=6&db=m [Eosinophil and neutrophil degranulation in allergic inflammation: immunohistochemical localization of granule proteins in fatal asthma and stimulus-dependent degranulation in vitro] causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8012277&form=6&db=m C5a stimulus-secretion coupling in rat basophilic leukaemia (RBL-2H3) cells transfected with the human C5a receptor is mediated by pertussis and cholera toxin-sensitive G proteins. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8012703&form=6&db=m Modulation of cardiac L-type Ca2+ channels by GTP gamma S in response to isoprenaline, forskolin and photoreleased nucleotides. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8013371&form=6&db=m Characterization of melatonin receptors and signal transduction system in rat arteries forming the circle of Willis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8013640&form=6&db=m A role for a pertussis toxin-sensitive trimeric G-protein in store-operated Ca2+ inflow in hepatocytes. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8014190&form=6&db=m How does the G protein, Gi2, transduce mitogenic signals? unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8014198&form=6&db=m Effect of prostaglandin F2 alpha on Ca2+ influx in osteoblast-like cells: function of tyrosine kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8014875&form=6&db=m Effects of adenosine receptor and muscarinic cholinergic receptor agonists on cardiac protein phosphorylation. Influence of pertussis toxin. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8014879&form=6&db=m Different signal transduction pathways are coupled to the nucleotide receptor and the P2Y receptor in C6 glioma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8014889&form=6&db=m Neurotensin excitation of rat ventral tegmental neurones. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8014890&form=6&db=m Enhancement of ATP-sensitive potassium current in cat ventricular myocytes by beta-adrenoreceptor stimulation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8014894&form=6&db=m Muscarine modulation by a G-protein alpha-subunit of delayed rectifier K+ current in rat ventromedial hypothalamic neurones. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8015650&form=6&db=m Regional characterization of G-protein subunits in glomeruli, cortices and medullas of the rat kidney. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8016410&form=6&db=m Neuropeptide Y stimulates proliferation of human vascular smooth muscle cells: cooperation with noradrenaline and ATP. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8019751&form=6&db=m Differential regulation of inositol 1,4,5-trisphosphate by co-existing P2Y-purinoceptors and nucleotide receptors on bovine aortic endothelial cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8019756&form=6&db=m 5-Hydroxytryptamine receptor-mediated phosphoinositide hydrolysis in canine cultured tracheal smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8019762&form=6&db=m Autocrine enhancement of leukotriene synthesis by endogenous leukotriene B4 and platelet-activating factor in human neutrophils. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8020490&form=6&db=m Deletion analysis of the m4 muscarinic acetylcholine receptor. Molecular determinants for activation of but not coupling to the Gi guanine-nucleotide-binding regulatory protein regulate receptor internalization. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8020870&form=6&db=m Purinergic receptors on insulin-secreting cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8020871&form=6&db=m Modulation of neurotransmitter release via histamine H3 heteroreceptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8022314&form=6&db=m Two phases of pseudopod protrusion in tumor cells revealed by a micropipette. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8022402&form=6&db=m Desensitization of the canine A2a adenosine receptor: delineation of multiple processes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8022777&form=6&db=m A membrane-delimited pathway of G-protein regulation of the guard-cell inward K+ channel. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8023737&form=6&db=m Guanine nucleotides and pertussis toxin reduce the affinity of histamine H3 receptors on AtT-20 cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8023891&form=6&db=m Angiotensin II stimulation of Na-H antiporter activity is cAMP independent in OKP cells. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8027031&form=6&db=m G-proteins modulate amiloride-sensitive sodium channels. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8027566&form=6&db=m Functional specialization of fibronectin-binding beta 1-integrins in T lymphocyte migration. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8028023&form=6&db=m Pharmacological characterization of A2-adenosine receptors in guinea-pig ventricular cardiomyocytes. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8029303&form=6&db=m Nicotine-induced antinociception in mice: role of G-proteins and adenylate cyclase. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8032613&form=6&db=m Coupling of a transfected human brain A1 adenosine receptor in CHO-K1 cells to calcium mobilisation via a pertussis toxin-sensitive mechanism. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8032627&form=6&db=m Sensitivity of G-protein involved in endothelin-1-induced Ca2+ influx to pertussis toxin in porcine endothelial cells in situ. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8032654&form=6&db=m Dual effects of mastoparan on intracellular free Ca2+ concentrations in human astrocytoma cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8032872&form=6&db=m Enhancement of neuronal calcium channel currents by the nootropic agent, nefiracetam (DM-9384), in NG108-15 cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8033344&form=6&db=m Endocytosis and uptake of lucifer yellow by cultured atrial myocytes and isolated intact atria from adult rats. Regulation and subcellular localization. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8033585&form=6&db=m Role of G-proteins in ciliary process adenylyl cyclase responses of the albino rabbit eye. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8033592&form=6&db=m Endotoxins in cholera and pertussis toxins interfere with in vivo responses to these agents in the albino rabbit eye. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8034040&form=6&db=m Phospholipase C activation and Ca2+ mobilization by cloned human somatostatin receptor subtypes 1-5, in transfected COS-7 cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8034731&form=6&db=m Angiotensin II-induced protein tyrosine phosphorylation in neonatal rat cardiac fibroblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8035314&form=6&db=m Mu and delta opioid receptor desensitization in undifferentiated human neuroblastoma SHSY5Y cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8037738&form=6&db=m Human growth hormone increases cytosolic free calcium in cultured human IM-9 lymphocytes: a novel mechanism of growth hormone transmembrane signalling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8038203&form=6&db=m Subcellular localization and kinetic characterization of guanine nucleotide binding proteins in normal rat and human pancreatic islets and transformed beta cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8039878&form=6&db=m Pertussis toxin activates platelets through an interaction with platelet glycoprotein Ib. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8040088&form=6&db=m G-proteins coupled to phosphoinositide hydrolysis in the cochlear and vestibular sensory epithelia of the rat are insensitive to cholera and pertussis toxins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8040182&form=6&db=m EGF modulates phosphoinositide levels in ovarian granulosa cells stimulated by luteinizing hormone. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8040337&form=6&db=m FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8045276&form=6&db=m Effect of carbachol in the absence and presence of phenylephrine on Rb+ efflux and tension in rabbit left atria. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8046455&form=6&db=m Augmentation of calcium channel currents in response to G protein activation by GTP gamma S in chick sensory neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8046943&form=6&db=m Ginseng root extract inhibits calcium channels in rat sensory neurons through a similar path, but different receptor, as mu-type opioids. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8048473&form=6&db=m HSP-72 synthesis is promoted by increase in [Ca2+]i or activation of G proteins but not pHi or cAMP. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8048563&form=6&db=m Prostaglandins mediate the defect in AVP-stimulated cAMP generation in immature collecting duct. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8049083&form=6&db=m Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8049523&form=6&db=m Polymerization of actin in RBL-2H3 cells can be triggered through either the IgE receptor or the adenosine receptor but different signaling pathways are used. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8050474&form=6&db=m Corticotropin-releasing factor increases [Ca2+]i via receptor-mediated Ca2+ channels in human epidermoid A-431 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8050479&form=6&db=m Activation of Gi protein by peptide structures of the muscarinic M2 receptor second intracellular loop. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8050482&form=6&db=m Coupling of inhibitory receptors with Gi-proteins in hamster adipocytes: comparison between adenosine A1 receptor and alpha 2-adrenoceptor. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8051693&form=6&db=m G-protein activation mediates prepulse facilitation of Ca2+ channel currents in bovine chromaffin cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8053161&form=6&db=m Pertussis toxin inhibits induction of human immunodeficiency virus type 1 in infected monocytes. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8056775&form=6&db=m Possible involvement of a pertussis toxin-sensitive GTP-binding protein in protein transport into nuclei isolated from rat liver. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8057394&form=6&db=m Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8058054&form=6&db=m Receptors for pancreastatin in rat liver membranes: molecular identification and characterization by covalent cross-linking. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8058061&form=6&db=m Expression of a cloned P2Y purinergic receptor that couples to phospholipase C. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8058106&form=6&db=m Signal transduction pathway of the muscarinic receptors mediating gallbladder contraction. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8058107&form=6&db=m Histamine H1-receptors in HL-60 monocytes are coupled to Gi-proteins and pertussis toxin-insensitive G-proteins and mediate activation of Ca2+ influx without concomitant Ca2+ mobilization from intracellular stores. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8059062&form=6&db=m Changes in cAMP formation in mononuclear leukocytes of heart and renal transplant recipients. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8062159&form=6&db=m Effects of genistein, tyrphostin, and pertussis toxin on EGF-induced mitogenesis in primary culture and clonal osteoblastic cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8063754&form=6&db=m Ability of delta-opioid receptors to interact with multiple G-proteins is independent of receptor density. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8063808&form=6&db=m Induction of actin polymerization in permeabilized neutrophils. Role of ATP. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8064231&form=6&db=m Pertussis toxin inhibits activation-induced cell death of human thymocytes, pre-B leukemia cells and monocytes. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8064363&form=6&db=m Trans-ACPD, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8067390&form=6&db=m ATP inhibits the hydrosmotic effect of AVP in rabbit CCT: evidence for a nucleotide P2u receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8067409&form=6&db=m G protein expression and adenylate cyclase regulation in ventricular cardiomyocytes from STZ-diabetic rats. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8069630&form=6&db=m AB5 ADP-ribosylating toxins: comparative anatomy and physiology. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8071211&form=6&db=m Detection and subcellular localization of three Ptl proteins involved in the secretion of pertussis toxin from Bordetella pertussis. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8071650&form=6&db=m Cortisol inhibition of growth hormone-releasing hormone-stimulated growth hormone release from cultured sheep pituitary cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8071838&form=6&db=m Opioid inhibition and desensitization of calcium channel currents in rat dorsal root ganglion neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8075892&form=6&db=m The effects of sigma ligands and of neuropeptide Y on N-methyl-D-aspartate-induced neuronal activation of CA3 dorsal hippocampus neurones are differentially affected by pertussin toxin. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8075982&form=6&db=m The crystal structure of pertussis toxin. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8076690&form=6&db=m Effect of lysophosphatidic acid on the preimplantation development of mouse embryos. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8077253&form=6&db=m Mechanisms of biomaterial-induced superoxide release by neutrophils. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8077734&form=6&db=m Antibodies to filamentous hemagglutinin of Bordetella pertussis and protection against whooping cough in schoolchildren. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8078296&form=6&db=m Association of heterotrimeric GTP binding regulatory protein (Go) with mitosis. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8080138&form=6&db=m Pertussis seroprevalence in emergency department staff. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8081716&form=6&db=m Cannabinoids modulate potassium current in cultured hippocampal neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8081727&form=6&db=m Functional coupling between endothelin receptors and multiple G-proteins in rat heart myocytes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8081728&form=6&db=m Inhibitory effect of neuropeptide Y and its analogues on inositol 1,4,5-trisphosphate level in rat cardiomyocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8082634&form=6&db=m Amygdaloid kindling elicits persistent changes in pertussis toxin-catalyzed ADP-ribosylation. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8082781&form=6&db=m A C-terminally truncated human parathyroid hormone receptor is functional and activates multiple G proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8082794&form=6&db=m Inhibition by PGE2 of glucagon-induced increase in phosphoenolpyruvate carboxykinase mRNA and acceleration of mRNA degradation in cultured rat hepatocytes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8082877&form=6&db=m Augmentation of tumor necrosis factor-alpha-induced monocytic differentiation of a myelomonocytic leukemia (WEHI-3B JCS) by pertussis toxin. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8083156&form=6&db=m Mutations in the bvgA gene of Bordetella pertussis that differentially affect regulation of virulence determinants. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8083750&form=6&db=m GAP-43 amino terminal peptides modulate growth cone morphology and neurite outgrowth. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8087191&form=6&db=m Immunoglobulin E and G responses to pertussis toxin after booster immunization in relation to atopy, local reactions and aluminium content of the vaccines. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8087932&form=6&db=m Age-related changes in beta-adrenergic neuroeffector systems in the human heart. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8088367&form=6&db=m Functional characterization of the Na(+)-H+ exchanger in rat mast cells: crosstalks between different kinase pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8088374&form=6&db=m Steroid-sensitivity of agonist binding to pituitary cell line histamine H3 receptors. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8088866&form=6&db=m Studies on the lymphocytosis induced by pertussis toxin. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8089495&form=6&db=m Tyrosine kinase activation by Newcastle disease virus is required for TNF-alpha gene induction in astrocytes. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8090700&form=6&db=m Effects of diethyldithiocarbamate on activating mechanisms of neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8092250&form=6&db=m Hormonal regulation of MAP kinase in cultured rat inner medullary collecting tubule cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8092301&form=6&db=m Pertussis toxin-sensitive G proteins in regenerated endothelial cells of porcine coronary artery. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8093600&form=6&db=m Heterologous desensitization and reduced G protein ADP-ribosylation following exposure to alpha 2-adrenoceptor and muscarinic receptor agonists. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8094958&form=6&db=m Effect of inhibitors of distinct signalling pathways on neutrophil Q2- generation in response to tumor necrosis factor-alpha, and antibodies against CD18 and CD11a: evidence for a common and unique pattern of sensitivity to wortmannin and protein tyrosine kinase inhibitors. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8095076&form=6&db=m Somatostatin antagonizes angiotensin II effects on mesangial cell contraction and glomerular filtration. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8095458&form=6&db=m Protection against autoimmune disease by bacterial agents. II. PPD and pertussis toxin as proteins active in protecting mice against experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8095695&form=6&db=m Compartmentation of receptors and guanine nucleotide-binding proteins in NG108-15 cells: lack of cross-talk in agonist binding among the alpha 2-adrenergic, muscarinic, and opiate receptors. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8095921&form=6&db=m Receptor subtype involved and mechanism of norepinephrine-induced stimulation of glutamate uptake into primary cultures of rat brain astrocytes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8095934&form=6&db=m Pertussis toxin inhibition of alpha 1-adrenergic or vasopressin-induced Ca2+ fluxes in rat liver. Selective inhibition of the alpha 1-adrenergic receptor-coupled metabolic activation. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8097328&form=6&db=m Coupling of m2 and m4 muscarinic acetylcholine receptor subtypes to Ca(2+)-dependent K+ channels in transformed NL308 neuroblastoma x fibroblast hybrid cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8097462&form=6&db=m Cardiac alpha 1-adrenoceptors stimulate a high-affinity GTPase activity in sarcolemmal membranes from rabbit atrial and ventricular myocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8097891&form=6&db=m Mechanisms of action of long-acting analogs of somatostatin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8098045&form=6&db=m Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8098716&form=6&db=m In vitro modulation of growth hormone (GH) secretion from early to midgestation human fetal pituitaries by GH-releasing factor and somatostatin: role of Gs-adenylate cyclase-Gi complex and Ca2+ channels. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8098766&form=6&db=m Neuropeptide Y and pancreatic polypeptide reduce calcium currents in acutely dissociated neurons from adult rat superior cervical ganglia. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8098912&form=6&db=m GABA mediation of the dual effects of somatostatin on guinea pig ileal myenteric cholinergic transmission. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8099279&form=6&db=m Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8099284&form=6&db=m Functional alpha 2-adrenergic receptor-Gs coupling undergoes agonist-promoted desensitization in a subtype-selective manner. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8100066&form=6&db=m Involvement of nitric oxide and peptides in the inhibitory non-adrenergic, non-cholinergic (NANC) response in bovine mesenteric artery. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8100230&form=6&db=m Thy-1 antibody-triggered neurite outgrowth requires an influx of calcium into neurons via N- and L-type calcium channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8100352&form=6&db=m Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8100541&form=6&db=m Somatostatin induces release of the alpha subunits of pertussis toxin-sensitive G proteins in native membranes and in intact GH4C1 rat pituitary cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8100816&form=6&db=m Altered beta-adrenergic receptor-stimulated cAMP formation in cultured skin fibroblasts from Alzheimer donors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8100980&form=6&db=m The stimulatory and inhibitory effects of quinpirole hydrochloride, D2-dopamine receptor agonist, on secretion of prolactin as assessed by the reverse hemolytic plaque assay. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8100988&form=6&db=m Somatostatin modulation of adenosine receptor coupled G-protein subunits in the caudate nucleus of the rat. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8102378&form=6&db=m Multiple G-protein-dependent pathways mediate the antisecretory effects of somatostatin and clonidine in the HT29-19A colonic cell line. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8102483&form=6&db=m PGE2-induced inhibition of AVP-dependent cAMP accumulation in the OMCD of the rat kidney is cumulative with respect to the effects of alpha 2-adrenergic and alpha 1-adenosine agonists, insensitive to pertussis toxin and dependent on extracellular calcium. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8102492&form=6&db=m Effect of somatostatin on contractile and relaxant responses of tracheal smooth muscle in rabbits. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8102606&form=6&db=m Cannabinoids inhibit agonist-stimulated formation of inositol phosphates in rat hippocampal cultures. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8102784&form=6&db=m Mutation of an aspartate at residue 89 in somatostatin receptor subtype 2 prevents Na+ regulation of agonist binding but does not alter receptor-G protein association. diagnostic usage,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8102785&form=6&db=m Characterization of cloned somatostatin receptors SSTR4 and SSTR5. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8103083&form=6&db=m Dopamine agonist-mediated inhibition of acetylcholine release in rat striatum is modified by thyroid hormone status. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8103326&form=6&db=m Further characterization of the D2 dopamine receptor expressed in MMQ cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8103519&form=6&db=m The release of endothelium-derived relaxing factor via alpha 2-adrenergic receptor activation is specifically mediated by Gi alpha 2. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8103554&form=6&db=m Kinetic basis for the voltage-dependent inhibition of N-type calcium current by somatostatin and norepinephrine in chick sympathetic neurons. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8103800&form=6&db=m The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line is coupled to adenylyl cyclase through a pertussis toxin-sensitive guanine nucleotide-binding regulatory protein. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8104151&form=6&db=m Alpha 1B-adrenoceptor-mediated stimulation of Ca2+ mobilization and cAMP accumulation in isolated rat hepatocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8106008&form=6&db=m Norepinephrine-stimulated PI hydrolysis in oligodendrocytes is mediated by alpha 1A-adrenoceptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8106134&form=6&db=m Chick embryo, a model to study the lethal activity of pertussis toxin, infectivity of Bordetella pertussis, and their neutralization by immune sera. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8106357&form=6&db=m Basic fibroblast growth factor-stimulated endothelial cell movement is mediated by a pertussis toxin-sensitive pathway regulating phospholipase A2 activity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8106442&form=6&db=m Rapid induction of arachidonic acid release by monocyte chemotactic protein-1 and related chemokines. Role of Ca2+ influx, synergism with platelet-activating factor and significance for chemotaxis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8106573&form=6&db=m Cross-talk of parathyroid hormone-responsive dual signal transduction systems in osteoblastic osteosarcoma cells: its role in PTH-induced homologous desensitization of intracellular calcium response. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8112026&form=6&db=m Diagnostic evaluation of polymerase chain reaction discriminative for Bordetella pertussis, B. parapertussis, and B. bronchiseptica. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8112401&form=6&db=m Modulation by pertussis toxin of salbutamol- and arecoline-induced effects in the isolated heart and aorta of the rat. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8113670&form=6&db=m Role in host cell invasion of Trypanosoma cruzi-induced cytosolic-free Ca2+ transients. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8113787&form=6&db=m mu-Opioid receptor stimulation of inositol (1,4,5)trisphosphate formation via a pertussis toxin-sensitive G protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8114012&form=6&db=m Inhibition of cholinergic transmission by opiates in ileal myenteric plexus is mediated by kappa receptor. Involvement of regulatory inhibitory G protein and calcium N-channels. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8114072&form=6&db=m Cough production, leucocytosis and serology of rats infected intrabronchially with Bordetella pertussis. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8114080&form=6&db=m Initiation of RVD response in human platelets: mechanical-biochemical transduction involves pertussis-toxin-sensitive G protein and phospholipase A2. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8117336&form=6&db=m [Localization of segments in the Gs protein interacting with adenylate cyclase using a Gs/G0-chimera] diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8118033&form=6&db=m Priming effects of granulocyte-macrophage colony-stimulating factor are coupled to cholera toxin-sensitive guanine nucleotide binding protein in human T lymphocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8118041&form=6&db=m Polymorphonuclear leukocyte dysregulation during the systemic inflammatory response syndrome. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8119169&form=6&db=m The effect of pertussis toxin on the growth of vascular smooth muscle cells stimulated by serum or platelet-derived growth factor. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8119196&form=6&db=m Activation of inositol phospholipid turnover and calcium signaling in rat Sertoli cells by P2-purinergic receptors: modulation of follicle-stimulating hormone responses. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8119317&form=6&db=m Effect of pertussis toxin treatment on the putative adenosine A3 receptor-mediated hypotensive response in the rat. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8119395&form=6&db=m Guanosine 5'-(gamma-thio) triphosphate (GTP gamma S) inhibits phosphorylation of insulin receptor and a novel GTP-binding protein, Gir, from human placenta. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8119927&form=6&db=m Sphingosine-mediated phosphatidylinositol metabolism and calcium mobilization. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8119996&form=6&db=m The NAD-glycohydrolase activity of the pertussis toxin S1 subunit. Involvement of the catalytic HIS-35 residue. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8120807&form=6&db=m Modulation of basal L-type Ca2+ current by adenosine in ferret isolated right ventricular myocytes. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8120808&form=6&db=m Modulation of L-type Ca2+ current by extracellular ATP in ferret isolated right ventricular myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8120813&form=6&db=m M1 muscarinic receptors increase calcium current and phosphoinositide turnover in guinea-pig ventricular cardiocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8123588&form=6&db=m Characterization of somatostatin receptors on human neuroblastoma tumors. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8125125&form=6&db=m C3a activates reactive oxygen radical species production and intracellular calcium transients in human eosinophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8125925&form=6&db=m Epidermal growth factor-induced activation and translocation of phospholipase C-gamma 1 to the cytoskeleton in rat hepatocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8125934&form=6&db=m Androgens increase intracellular calcium concentration and inositol 1,4,5-trisphosphate and diacylglycerol formation via a pertussis toxin-sensitive G-protein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8126079&form=6&db=m Catecholamine stimulated lipolysis in differentiated human preadipocytes in a serum-free, defined medium. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8126104&form=6&db=m Binding of the cytosolic p200 protein to Golgi membranes is regulated by heterotrimeric G proteins. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8127904&form=6&db=m Lysophosphatidic acid possesses dual action in cell proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8130081&form=6&db=m Phosphatidic acid and phospholipase D both stimulate phosphoinositide turnover in cultured human keratinocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8132498&form=6&db=m Differential regulation by cAMP-dependent protein kinase and protein kinase C of the mu opioid receptor coupling to a G protein-activated K+ channel. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8132547&form=6&db=m A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8132619&form=6&db=m Y2 receptors for neuropeptide Y are coupled to three intracellular signal transduction pathways in a human neuroblastoma cell line. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8132705&form=6&db=m NIH3T3 cells expressing the deleted in colorectal cancer tumor suppressor gene product stimulate neurite outgrowth in rat PC12 pheochromocytoma cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8133273&form=6&db=m Endothelin- and sarafotoxin-induced phosphoinositide hydrolysis in cultured canine tracheal smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8133900&form=6&db=m Cell-specific coupling of the cloned human 5-HT1F receptor to multiple signal transduction pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8134615&form=6&db=m Insulin-like growth factors enhance phagocytosis by human neutrophils in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8135758&form=6&db=m Prostaglandin F2 alpha-stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: involvement in sustained 1,2-diacylglycerol production. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8135760&form=6&db=m Stimulation of high-affinity GTPase activity and cholera toxin-catalysed [32P]ADP-ribosylation of Gi by lysophosphatidic acid (LPA) in wild-type and alpha 2C10 adrenoceptor-transfected Rat 1 fibroblasts. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8136044&form=6&db=m Fear-potentiated startle: a neural and pharmacological analysis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8137877&form=6&db=m Interleukin-1 beta inhibits Ca2+ channel currents in hippocampal neurons through protein kinase C. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8141254&form=6&db=m Calcium-dependent release of arachidonic acid in response to purinergic receptor activation in airway epithelium. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8141291&form=6&db=m Effects of prostaglandins on gastrin release from canine antral mucosal cells in primary culture. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8141766&form=6&db=m Intracellular Ca2+, inositol 1,4,5-trisphosphate and additional signalling in the stimulation by platelet-activating factor of prostaglandin E2 formation in P388D1 macrophage-like cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8143844&form=6&db=m Dual pertussis toxin-sensitive pathway of zymosan-induced activation in guinea pig macrophages. An anti-CR3 antibody-inhibitable stimulation of phagocytosis and -resistant stimulation of O2- production and arachidonate release. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8144593&form=6&db=m Role of histidine 35 of the S1 subunit of pertussis toxin in the ADP-ribosylation of transducin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8144604&form=6&db=m Protein kinase A phosphorylation and G protein regulation of purified renal Na+ channels in planar bilayer membranes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8144617&form=6&db=m Subtype-specific signaling mechanisms of somatostatin receptors SSTR1 and SSTR2. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8144703&form=6&db=m Distribution and role of heterotrimeric G proteins in the secretory pathway of polarized epithelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8144937&form=6&db=m Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3. Similarities and differences with MCP-1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8145725&form=6&db=m Sensitization of adenylate cyclase by halothane in human myocardium and S49 lymphoma wild-type and cyc- cells: evidence for inactivation of the inhibitory G protein Gi alpha. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8145727&form=6&db=m Pituitary cell line GH3 expresses two somatostatin receptor subtypes that inhibit adenylyl cyclase: functional expression of rat somatostatin receptor subtypes 1 and 2 in human embryonic kidney 293 cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8145728&form=6&db=m Rat somatostatin receptor type 1 couples to G proteins and inhibition of cyclic AMP accumulation. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8145737&form=6&db=m Determinants of alpha 2-adrenergic receptor activation of G proteins: evidence for a precoupled receptor/G protein state. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8146596&form=6&db=m Characterization of a cyclosporin A-sensitive activation pathway in cultured T and natural killer cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8147266&form=6&db=m Interactions of bradykinin, calcium, G-protein and protein kinase in the activation of phospholipase A2 in bovine pulmonary artery endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8148040&form=6&db=m Direct effect of adenosine on prolactin secretion at the level of the single rat lactotroph: involvement of pertussis toxin-sensitive and -insensitive transducing mechanisms. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8151353&form=6&db=m Expression of a functional endothelin (ETA) receptor in human meningiomas. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8152537&form=6&db=m Status epilepticus may be caused by loss of adenosine anticonvulsant mechanisms. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8157083&form=6&db=m Zinc hydroxide induced respiratory burst in rat neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8157503&form=6&db=m ATP-induced cytoplasmic [Ca2+] increases in isolated cochlear outer hair cells. Involved receptor and channel mechanisms. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8158247&form=6&db=m Opioids mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8158251&form=6&db=m Neurosteroids modulate calcium currents in hippocampal CA1 neurons via a pertussis toxin-sensitive G-protein-coupled mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8160798&form=6&db=m Increased cytosolic Ca2+ inhibits AVP-stimulated adenylyl cyclase activity in rat IMCT cells by activation of PKC. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8160800&form=6&db=m Parathyroid hormone inhibits Na(+)-K(+)-ATPase through a cytochrome P-450 pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8161224&form=6&db=m Characterization and subcellular distribution of G-proteins in highly purified skeletal muscle fractions from rabbit and frog. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8163481&form=6&db=m Identification of a uridine nucleotide-selective G-protein-linked receptor that activates phospholipase C. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8165565&form=6&db=m The role of autotaxin and other motility stimulating factors in the regulation of tumor cell motility. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8166242&form=6&db=m Modulation of intracellular calcium transients and dopamine release by neuropeptide Y in PC-12 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8166262&form=6&db=m Increase in cytosolic free Ca2+ in corticotropin-stimulated white adipocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8166643&form=6&db=m Effect of sphingosine derivatives on calcium fluxes in thyroid FRTL-5 cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8167155&form=6&db=m Multiple signalling pathways in the C5a-induced expression of adhesion receptor Mac-1. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8168540&form=6&db=m Inhibition of glycogen synthesis by epidermal growth factor in hepatocytes. The role of cell density and pertussis toxin-sensitive GTP-binding proteins. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8168972&form=6&db=m Assignment of functional domains involved in ADP-ribosylation and B-oligomer binding within the carboxyl terminus of the S1 subunit of pertussis toxin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8170523&form=6&db=m Neuropeptide Y enhances LHRH binding to rat gonadotrophs in primary culture. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8170728&form=6&db=m Safety, immunogenicity and an open, retrospective study of efficacy of a monocomponent pertussis toxoid vaccine in infants. diagnostic usage,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8172600&form=6&db=m A slowly ADP-ribosylated pertussis-toxin-sensitive GTP-binding regulatory protein is required for vasopressin-stimulated Ca2+ inflow in hepatocytes. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8175684&form=6&db=m Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8175713&form=6&db=m Human 5-HT1A receptor expressed in insect cells activates endogenous G(o)-like G protein(s). diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8175717&form=6&db=m Inhibition of Gi proteins by low density lipoprotein attenuates bradykinin-stimulated release of endothelial-derived nitric oxide. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8175730&form=6&db=m Alpha 2A adrenergic receptors inhibit cAMP accumulation in embryonic stem cells which lack Gi alpha 2. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8175755&form=6&db=m Selective activation of Gi1 and Gi2 in mouse sperm by the zona pellucida, the egg's extracellular matrix. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8176718&form=6&db=m Responses to Bordetella pertussis mutant strains and to vaccination in the coughing rat model of pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8177498&form=6&db=m Endothelin-3 activates a voltage-gated Ca channel via a pertussis toxin sensitive mechanism leading to dopamine release from PC12 cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8177626&form=6&db=m Comparison of a three-component acellular pertussis vaccine with whole cell pertussis vaccine in two-month-old children. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8179014&form=6&db=m Activation of G proteins may inhibit or stimulate surfactant secretion in rat alveolar type II cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8179336&form=6&db=m Effect of cholera toxin and pertussis toxin on prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinase production by human monocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8179614&form=6&db=m Tyrosine phosphorylation of a 58 kDa protein induced by morphine in SK-N-SH cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8180340&form=6&db=m Regulation of thrombin-induced endothelial cell activation by bacterial toxins. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8180641&form=6&db=m Comparison of a three-component acellular pertussis vaccine with a whole-cell pertussis vaccine in 4- through 6-year-old children. Elmwood Pediatric Associates, Pennridge Pediatric Associates. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8181456&form=6&db=m Increased incorporation of arachidonic acid into phospholipids in zymosan-stimulated mouse peritoneal macrophages. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8182092&form=6&db=m The homophilic binding site of the neural cell adhesion molecule NCAM is directly involved in promoting neurite outgrowth from cultured neural retinal cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8182518&form=6&db=m Dopamine inhibits a sustained calcium current through activation of alpha adrenergic receptors and a GTP-binding protein in adult rat sympathetic neurons. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8182531&form=6&db=m Muscarinic cholinergic agonists stimulate arachidonic acid release from mouse striatal neurons in primary culture. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8184900&form=6&db=m Effects of endothelin on rat renal proximal tubule Na(+)-Pi cotransport and Na+/H+ exchange. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8184901&form=6&db=m Second messengers involved in the control of renin secretion in cultured human nephroblastoma cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8184904&form=6&db=m Regulation of G proteins by adenosine receptor agonist in coronary artery. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8187281&form=6&db=m High-density lipoprotein stimulates endothelial cell movement by a mechanism distinct from basic fibroblast growth factor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8188757&form=6&db=m Peripheral and central vascular smooth muscle cells from rat lung exhibit different cytoskeletal protein profiles but similar growth factor requirements. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8190094&form=6&db=m A single species of A1 adenosine receptor expressed in Chinese hamster ovary cells not only inhibits cAMP accumulation but also stimulates phospholipase C and arachidonate release. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8190126&form=6&db=m Involvement of the pertussis toxin-sensitive GTP-binding protein in regulation of expression and function of granulocyte complement receptor type 1 and type 3. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8192649&form=6&db=m Collagen type IV stimulates an increase in intracellular Ca2+ in pancreatic acinar cells via activation of phospholipase C. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8192675&form=6&db=m Permissive stimulation of Ca(2+)-induced phospholipase A2 by an adenosine receptor agonist in a pertussis toxin-sensitive manner in FRTL-5 thyroid cells: a new 'cross-talk' mechanism in Ca2+ signalling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8193368&form=6&db=m C3a activates the respiratory burst in human polymorphonuclear neutrophilic leukocytes via pertussis toxin-sensitive G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8193581&form=6&db=m Involvement of G proteins in the effect of insulin-like growth factor I on gonadotropin-induced rat granulosa cell differentiation. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8195239&form=6&db=m Thrombin-mediated phosphoinositide hydrolysis in Chinese hamster ovary cells overexpressing phospholipase C-delta 1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8195394&form=6&db=m Identification of Bordetella pertussis infection by shared-primer PCR. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8195705&form=6&db=m HOCl production by human neutrophils activated by surface-associated IgG: requirement for influx of extracellular calcium. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8196499&form=6&db=m Pertussis toxin normalizes enhanced renovascular responses to angiotensin II in spontaneously hypertensive rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8196611&form=6&db=m Evidence that v-Src-induced phospholipase D activity is mediated by a G protein. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8198537&form=6&db=m Exocytosis in chromaffin cells: evidence for a MgATP-independent step that requires a pertussis toxin-sensitive GTP-binding protein. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8198593&form=6&db=m Enhancement of adenylate cyclase stimulation by prostaglandin E receptor EP3 subtype isoforms with different efficiencies. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8200614&form=6&db=m Pertussis toxin enhances fetal calf serum-induced alkaline phosphatase activity in osteoblast-like cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8200984&form=6&db=m Pertussis toxin treatment alters manganese superoxide dismutase activity in lung. Evidence for lung oxygen toxicity in air-breathing rats. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8201477&form=6&db=m Comparative study of a whole-cell pertussis vaccine and a recombinant acellular pertussis vaccine. The Italian Multicenter Group for the Study of Recombinant Acellular Pertussis Vaccine. diagnostic usage,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8203563&form=6&db=m Adenosine A1 receptor-mediated inhibition of vasopressin action in inner medullary collecting duct. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8203580&form=6&db=m Acetylcholine-sensitive muscarinic K+ channels in mammalian ventricular myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8203713&form=6&db=m Evidence for guanosine triphosphate--binding proteins in Trypanosoma cruzi. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8206633&form=6&db=m Enhanced vascular reactivity to mastoparan, a G protein activator, in genetically hypertensive rats. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8206984&form=6&db=m A novel synergistic stimulation of Swiss 3T3 cells by extracellular ATP and mitogens with opposite effects on cAMP levels. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8206993&form=6&db=m 5-Hydroxytryptamine1A receptor synthetic peptides. Mechanisms of adenylyl cyclase inhibition. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8207076&form=6&db=m Lamellipod extension and K+ current in osteoclasts are regulated by different types of G proteins. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8207425&form=6&db=m Activation of opioid and muscarinic receptors stimulates basal adenylyl cyclase but inhibits Ca2+/calmodulin- and forskolin-stimulated enzyme activities in rat olfactory bulb. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8207477&form=6&db=m Adenosine acting at an A1 receptor decreases N-type calcium current in mouse motoneurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8207492&form=6&db=m mu-Opioid receptor-mediated reduction of neuronal calcium current occurs via a G(o)-type GTP-binding protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8208303&form=6&db=m Presynaptic opioid receptors on dopaminergic nerves in the rabbit caudate nucleus: coupling to pertussis toxin-sensitive G-proteins and interaction with D2 autoreceptors? therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8208666&form=6&db=m GTP-binding proteins associated with the human placental syncytiotrophoblast plasma membrane. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8209785&form=6&db=m Agonist receptors and G proteins as mediators of platelet activation. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8214135&form=6&db=m Antagonism of LTD4-evoked relaxation in canine renal artery and vein. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8216254&form=6&db=m Thyrotropin stimulates invasion and growth of follicular thyroid cancer cells via PKC- rather than PKA-activation. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8216302&form=6&db=m Cellular cyclic AMP levels modulate insulin sensitivity and responsiveness--evidence against a significant role of Gi in insulin signal transduction. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8217117&form=6&db=m Assay of pertussis vaccine reactivity factors by measurement of the paw swelling response, endotoxin and histamine-sensitizing factor. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8217196&form=6&db=m Expression of muscarinic M2 receptors in cultured human airway smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8217790&form=6&db=m The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8218364&form=6&db=m Activation of the respiratory burst and tyrosine phosphorylation of proteins in human neutrophils: no direct relationship and involvement of protein kinase C-dependent and -independent signaling pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8222075&form=6&db=m Platelets from spontaneously hypertensive rats exhibit decreased expression of inhibitory guanine nucleotide regulatory protein. Relation with adenylyl cyclase activity. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8223566&form=6&db=m Complement fragment C3a stimulates Ca2+ influx in neutrophils via a pertussis-toxin-sensitive G protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8223658&form=6&db=m Western blot analysis of antibody responses of young infants to pertussis infection. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8224171&form=6&db=m rab3-peptide stimulates exocytosis from mast cells via a pertussis toxin-sensitive mechanism. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8224444&form=6&db=m Intracellular cross-talk between receptors coupled to phospholipase C via pertussis toxin sensitive and insensitive G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8224610&form=6&db=m Lysophosphatidic acid mimics serum-induced sensitization of cyclic AMP accumulation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8225200&form=6&db=m Regulation of calcitonin secretion in vitro. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8226727&form=6&db=m Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8226853&form=6&db=m Mastoparan stimulates exocytosis at a Ca(2+)-independent late site in stimulus-secretion coupling. Studies with the RINm5F beta-cell line. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8226869&form=6&db=m Ethanol differentially increases alpha 2-adrenergic and muscarinic acetylcholine receptor gene expression in NG108-15 cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8227038&form=6&db=m ATP and A1 adenosine receptor agonists mobilize intracellular calcium and activate K+ and Cl- currents in normal and cystic fibrosis airway epithelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8227073&form=6&db=m Angiotensin II stimulates the synthesis of angiotensinogen in hepatocytes by inhibiting adenylylcyclase activity and stabilizing angiotensinogen mRNA. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8227189&form=6&db=m Vasopressin induces arachidonic acid release through pertussis toxin-sensitive GTP-binding protein in aortic smooth muscle cells: independence from phosphoinositide hydrolysis. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8227332&form=6&db=m The G proteins of the G alpha i and G alpha q family couple the bradykinin receptor to the release of endothelium-derived relaxing factor. causal interaction,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8228255&form=6&db=m Triggering of degranulation in mast cells by exogenous type II phospholipase A2. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8228256&form=6&db=m Signal transducing properties of the N-formyl peptide receptor expressed in undifferentiated HL60 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8228623&form=6&db=m Lipopolysaccharide structure-function relationship in activation versus reprogramming of mouse peritoneal macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8228985&form=6&db=m ATP-induced secretion in PC12 cells and photoaffinity labeling of receptors. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8229757&form=6&db=m Platelet-activating factor (PAF) induces a contraction of isolated smooth muscle cells from guinea pig ileum: intracellular pathway involved. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8229856&form=6&db=m Histamine activates Cl- and K+ currents in guinea-pig tracheal myocytes: convergence with muscarinic signalling pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8230243&form=6&db=m Pertussis toxin blocks adenosine A1 receptor mediated protection of the ischemic rat heart. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8232229&form=6&db=m Coupling of expressed alpha 1B- and alpha 1D-adrenergic receptor to multiple signaling pathways is both G protein and cell type specific. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8232231&form=6&db=m Selective coupling of alpha 2-adrenergic receptor subtypes to cyclic AMP-dependent reporter gene expression in transiently transfected JEG-3 cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8232606&form=6&db=m Pronounced direct inhibitory action mediated by adenosine A1 receptor and pertussis toxin-sensitive G protein on the ferret ventricular contraction. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8238320&form=6&db=m G protein-mediated inhibition of inwardly rectifying K+ channels in guinea pig chromaffin cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8238388&form=6&db=m Transforming growth factor-beta 1 regulation of signal transduction in two renal epithelial cell lines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8238544&form=6&db=m Evidence that separate PGE2 receptors modulate water and sodium transport in rabbit cortical collecting duct. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8240277&form=6&db=m Characterization of a complement-fragment-C5a-stimulated calcium-influx mechanism in U937 monocytic cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8242419&form=6&db=m [Membrane receptors and coupling proteins in adenohypophyseal cells] causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8243300&form=6&db=m Cholera toxin and dibutyryl cyclic adenosine 3',5'-monophosphate sensitize gonadotropin-releasing hormone-stimulated inositol phosphate production to inhibition in protein kinase-C (PKC)-depleted cells: evidence for cross-talk between a cholera toxin-sensitive G-protein and PKC. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8243309&form=6&db=m Estrogen uncouples beta-adrenergic receptor from the stimulatory guanine nucleotide-binding protein in female rat hypothalamus. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8243485&form=6&db=m Evaluation of pooled and individual components of Bordetella pertussis as antigens in an enzyme immunoassay for diagnosis of pertussis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8243809&form=6&db=m Thyrotropin-releasing hormone and gonadotropin-releasing hormone-associated peptide modulation of [Ca2+]i in human lactotrophs. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8245474&form=6&db=m Induction by chemokines of lipid mediator synthesis in granulocyte-macrophage colony-stimulating factor-treated human neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8245971&form=6&db=m Synergistic interaction of muscarinic and opioid receptors with GS-linked neurotransmitter receptors to stimulate adenylyl cyclase activity of rat olfactory bulb. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8250880&form=6&db=m Formation of inositol (1,4,5) trisphosphate and increase of cytosolic Ca2+ mediated by Fc receptors in human neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8252696&form=6&db=m Ischemic preconditioning is associated with a delay in ischemia-induced reduction of beta-adrenergic signal transduction in rabbit hearts. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8253125&form=6&db=m Cholera toxin antagonizes morphine-induced catalepsy through a cyclic AMP-independent mechanism. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8253518&form=6&db=m Regulation of melanoma-cell motility by the lipoxygenase metabolite 12-(S)-HETE. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8253719&form=6&db=m Opposite coupling of prostaglandin E receptor EP3C with Gs and G(o). Stimulation of Gs and inhibition of G(o). ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8253729&form=6&db=m Mitogenic signaling mechanisms of human cementum-derived growth factors. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8253976&form=6&db=m Comparison of polymerase chain reaction, culture, and western immunoblot serology for diagnosis of Bordetella pertussis infection. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8254196&form=6&db=m Signal transduction mechanisms for leukotriene B4 induced hyperadhesiveness of endothelial cells for neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8256656&form=6&db=m Tumor necrosis factor alpha modulates parathyroid hormone action in UMR-106-01 osteoblastic cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8260615&form=6&db=m Agonist-induced down-regulation of human 5-HT1A and 5-HT2 receptors in Swiss 3T3 cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8262641&form=6&db=m Depression of liver metabolism and induction of cytokine release by diphtheria and tetanus toxoids and pertussis vaccines: role of Bordetella pertussis cells in toxicity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8263518&form=6&db=m Agonist-induced, GTP-dependent phosphoinositide hydrolysis in postmortem human brain membranes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8263774&form=6&db=m Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8263781&form=6&db=m Distinct muscarinic receptors, G proteins and phospholipases in esophageal and lower esophageal sphincter circular muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8263953&form=6&db=m Alterations in alpha 1-adrenergic receptor-mediated phosphatidylinositol turnover in hypoxic cardiac myocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8263965&form=6&db=m Stretch-induced inositol trisphosphate and tetrakisphosphate production in rat cardiomyocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8264343&form=6&db=m Action of lipid peroxidation products on phosphoinositide specific phospholipase C. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8264421&form=6&db=m Production and release of tumor necrosis factor alfa, interleukin-1B and interleukin-6 by human mononuclear leukocytes stimulated with pertussis toxin. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8264871&form=6&db=m GnRH-associated peptide decreases cyclic AMP accumulation in the GH3 pituitary cell line. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8264967&form=6&db=m Neurite outgrowth of spinal neurons on tissue sections of embryonic muscle is largely integrin dependent. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8266828&form=6&db=m Cell signaling and estrogens in female rat osteoblasts: a possible involvement of unconventional nonnuclear receptors. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8270909&form=6&db=m Activation of Ca(2+)-dependent K+ current by acetylcholine and histamine in a human gastric epithelial cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8271196&form=6&db=m On the mechanism of M-current inhibition by muscarinic m1 receptors in DNA-transfected rodent neuroblastoma x glioma cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8271204&form=6&db=m Whole-cell recordings of inwardly rectifying K+ currents activated by 5-HT1A receptors on dorsal raphe neurones of the adult rat. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8271267&form=6&db=m Mobilization of intracellular calcium in cultured vascular smooth muscle cells by uridine triphosphate and the calcium ionophore A23187. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8273284&form=6&db=m Serotonergic, 5-HT2, receptor-mediated phosphoinositide turnover and mobilization of calcium in cultured rat retinal pigment epithelium cells. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8274148&form=6&db=m C-terminal modifications of pertussis toxin-sensitive G-protein alpha-subunits differentially affect immunoreactivity. Evidence against endogenous ADP-ribosylation in human heart, lung, thrombocytes and adipose tissue. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8275927&form=6&db=m Activation of the Ca2+ message system by parathyroid hormone is dependent on the cell cycle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8275946&form=6&db=m The relationship between 3',5'-cyclic adenosine monophosphate and calcium in mediating follicle-stimulating hormone signal transduction in Sertoli cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8276129&form=6&db=m Effects of adenosine analog PIA (n-phenylisopropyladenosine) on FSH-stimulated cyclic AMP (cAMP) production in the rat seminiferous epithelium. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8276143&form=6&db=m Effects of glucagon like peptide-1(7-36) amide on the cytoplasmic Ca(2+)-concentration in rat islet cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8276210&form=6&db=m Saccharomyces boulardii inhibits secretagogue-mediated adenosine 3',5'-cyclic monophosphate induction in intestinal cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8276865&form=6&db=m Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8278307&form=6&db=m Polymorphonuclear leukocytes activation: in vitro modulation by 6-methoxy-2-naphthylacetic acid, the major active metabolite of nabumetone. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8278447&form=6&db=m Pertussis toxin attenuates intracranial morphine self-administration. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8280770&form=6&db=m Ethanol inhibits zymosan-stimulated eicosanoid production in mouse peritoneal macrophages. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8281925&form=6&db=m Glycogenolytic and antiglycogenolytic prostaglandin E2 actions in rat hepatocytes are mediated via different signalling pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8282000&form=6&db=m G proteins in aortic endothelial cells and bradykinin-induced formation of nitric oxide. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8282007&form=6&db=m The human and dog 5-HT1D receptors can both activate and inhibit adenylate cyclase in transfected cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8282011&form=6&db=m Extracellular ATP elevates cytoplasmatic free Ca2+ in HeLa cells by the interaction with a 5'-nucleotide receptor. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8282783&form=6&db=m Increased production of nitric oxide in coronary arteries during congestive heart failure. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8283213&form=6&db=m Muscarinic receptor activation of potassium channels in rat dentate gyrus neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8283837&form=6&db=m Effects of adenosine A1-agonist and -antagonist on urinary volume and Na excretion in IAP-treated and non-treated rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8287265&form=6&db=m Modulation of thymidine incorporation by kappa-opioid ligands in rat spinal cord-dorsal root ganglion co-cultures. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8287440&form=6&db=m Deaminovasopressin has direct and modulatory effects on ventricular automaticity in the rat heart. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8292355&form=6&db=m Bradykinin modulates potassium and calcium currents in neuroblastoma hybrid cells via different pertussis toxin-insensitive pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8293037&form=6&db=m Differentiation of BA-HAN-1C rhabdomyosarcoma cells is controlled by a pertussis toxin sensitive signaling pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8293574&form=6&db=m Ca2+ preconditioning elicits a unique protection against the Ca2+ paradox injury in rat heart. Role of adenosine. Fixed. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8294438&form=6&db=m Expression of a mutant Gi2 alpha subunit inhibits ATP and thrombin stimulation of cytoplasmic phospholipase A2-mediated arachidonic acid release independent of Ca2+ and mitogen-activated protein kinase regulation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8294449&form=6&db=m Melanoma growth stimulatory activity enhances the phosphorylation of the class II interleukin-8 receptor in non-hematopoietic cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8294489&form=6&db=m Transfected platelet-activating factor receptor activates mitogen-activated protein (MAP) kinase and MAP kinase kinase in Chinese hamster ovary cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8294914&form=6&db=m Guinea pig histamine H1 receptor. II. Stable expression in Chinese hamster ovary cells reveals the interaction with three major signal transduction pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8294922&form=6&db=m Endothelin-1 receptor binding and cellular signal transduction in cultured human brain endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8299148&form=6&db=m Assembly dynamics of actin in adherent human neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8300189&form=6&db=m A monoclonal anti-idiotypic antibody to opioid receptors labels desipramine-induced opioid binding sites on rat C6 glioma cells and attenuates thymidine incorporation into DNA. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8301138&form=6&db=m Involvement of a botulinum toxin-sensitive 22-kDa G protein in stimulated exocytosis of human neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8301592&form=6&db=m Pharmacological and functional characterization of D2, D3 and D4 dopamine receptors in fibroblast and dopaminergic cell lines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8301665&form=6&db=m Evidence that myocardial pertussis toxin substrates are uniquely altered in acute murine Chagas' disease in a manner unrelated to myocardial dysfunction. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8302280&form=6&db=m Activation of heterologously expressed D3 dopamine receptors: comparison with D2 dopamine receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8305442&form=6&db=m A novel mechanism for coupling of m4 muscarinic acetylcholine receptors to calmodulin-sensitive adenylyl cyclases: crossover from G protein-coupled inhibition to stimulation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8305985&form=6&db=m Spontaneous activity in transgenic mouse heart: comparison of primary atrial tumor with cultured AT-1 atrial myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8306105&form=6&db=m GABAB receptors modulate catecholamine secretion in chromaffin cells by a mechanism involving cyclic AMP formation. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8306196&form=6&db=m Neural effects of parathyroid hormone: modulation of the calcium channel current and metabolism of monoamines in identified Helisoma snail neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8306529&form=6&db=m Differential purification of autocrine motility factor derived from a murine protein-free fibrosarcoma. causal interaction,ongoing research,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8307163&form=6&db=m Structure and stability of pertussis toxin studied by in situ atomic force microscopy. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8307191&form=6&db=m Pertussis toxin-catalyzed ADP-ribosylation of GTP-binding proteins with digoxigenin-conjugated NAD. Identification of the proteins in plasma membranes and nuclei. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8307964&form=6&db=m Conditional activation of cAMP signal transduction by protein kinase C. The effect of phorbol esters on adenylyl cyclase in permeabilized and intact cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8308012&form=6&db=m Receptor-independent activation of guanine nucleotide-binding regulatory proteins by terminal complement complexes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8308742&form=6&db=m Mechanism of mu-opioid receptor-mediated presynaptic inhibition in the rat hippocampus in vitro. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8308743&form=6&db=m ATP modulation of calcium channels in chromaffin cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8309279&form=6&db=m Age-dependent alterations of human recombinant GM-CSF effects on human granulocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8311286&form=6&db=m Halothane and pertussis toxin-sensitive G proteins in airway smooth muscle. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8312133&form=6&db=m Evidence for involvement of a GTP-binding protein in activation of Ca2+ influx by epidermal growth factor in A431 cells: effects of fluoride and bacterial toxins. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8312135&form=6&db=m Age-dependent changes in transmembrane signalling: identification of G proteins in human lymphocytes and polymorphonuclear leukocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8312278&form=6&db=m Biochemical analysis of mutations at tyrosine-98 of the S1 subunit of pertussis toxin. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8313229&form=6&db=m Whole-cell Cl- currents in a human peripheral airway epithelial cell line. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8313426&form=6&db=m A phorbol ester augments cAMP content and adenylyl cyclase activity in neonatal rat cardiac myocytes despite reduced beta adrenoceptor density. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8314854&form=6&db=m Activation of phospholipase C by heat shock requires GTP analogs and is resistant to pertussis toxin. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8315346&form=6&db=m Phospholipase C and phospholipase D are activated independently of each other in chemotactic peptide-stimulated human neutrophils. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8315393&form=6&db=m Rapid G protein-regulated activation event involved in lymphocyte binding to high endothelial venules. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8318044&form=6&db=m Fc gamma receptor activation of neutrophils in cryoglobulin-induced leukocytoclastic vasculitis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8319575&form=6&db=m Pertussis toxin can distinguish the augmentary effect elicited by epidermal growth factor from that of phorbol ester on luteal adenylate cyclase activity. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8319753&form=6&db=m Opening of ATP-sensitive K+ channels responsible for adenosine A2 receptor-mediated vasodepression does not involve a pertussis toxin-sensitive G protein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8320270&form=6&db=m Activation of cellular phospholipase A2 by Clostridium difficile toxin B. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8320630&form=6&db=m Immunogenicity of an acellular pertussis vaccine composed of genetically inactivated pertussis toxin combined with filamentous hemagglutinin and pertactin in infants and children. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8320751&form=6&db=m Nerve growth factor changes G protein levels and localization in PC12 cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8321915&form=6&db=m Stimulation of glycogen degradation by prostaglandin E2 in primary cultured rat hepatocytes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8322922&form=6&db=m Postnatal decrease in muscarinic cholinergic influence on Ca2+ currents of rabbit ventricular cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8322930&form=6&db=m Parathyroid hormone increases cytosolic calcium concentration in adult rat cardiac myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8324794&form=6&db=m Preconditioning against infarction in the rat heart does not involve a pertussis toxin sensitive G protein. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8324804&form=6&db=m The antiarrhythmic effect of ischaemic preconditioning in isolated rat heart involves a pertussis toxin sensitive mechanism. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8324805&form=6&db=m The antiarrhythmic action of ischaemic preconditioning in rat hearts does not involve functional Gi proteins. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8325152&form=6&db=m Changes in vascular smooth muscle function in hypertension. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8325859&form=6&db=m Identification of a G protein alpha subunit from Neurospora crassa that is a member of the Gi family. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8326857&form=6&db=m Pertussis toxin export requires accessory genes located downstream from the pertussis toxin operon. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8329171&form=6&db=m Pertussis toxin does not affect the adenosine-induced inhibition of the efferent function of cardiac capsaicin-sensitive nerves. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8331165&form=6&db=m Enhancement of histamine-induced vascular leakage by pertussis toxin in SJL/J mice but not BALB/c mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8331558&form=6&db=m Diuretic and renal protective effects of 8-(noradamantan-3-yl)-1,3-dipropylxanthine (KW-3902), a novel adenosine A1-receptor antagonist, via pertussis toxin insensitive mechanism. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8335362&form=6&db=m Mechanisms of nonopsonic phagocytosis of Pseudomonas aeruginosa. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8341270&form=6&db=m Endothelin- and ATP-induced inhibition of adenylyl cyclase activity in C6 glioma cells: role of Gi and calcium. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8341668&form=6&db=m Stimulus-induced dissociation of alpha subunits of heterotrimeric GTP-binding proteins from the cytoskeleton of human neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8341673&form=6&db=m Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8342661&form=6&db=m Myogenic tone is coupled to phospholipase C and G protein activation in small cerebral arteries. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8343118&form=6&db=m Endothelins stimulate tyrosine phosphorylation and activity of p42/mitogen-activated protein kinase in astrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8343499&form=6&db=m The GTP-binding regulatory proteins, Gs and G(i), are altered in erythrocyte membranes of patients with ischemic heart disease resulting from coronary atherosclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8347349&form=6&db=m Localization of the GTP-binding protein Gi alpha in myelomonocytic progenitor cells is regulated by proliferation (GM-CSF, IL-3) and differentiation (TNF) signals. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8347421&form=6&db=m GTP[S] stimulates migration of electropermeabilized neutrophils via a pertussis toxin-sensitive G-protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8347925&form=6&db=m Differential regulation of Bordetella pertussis virulence factors. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8349024&form=6&db=m Calcitriol attenuates the thyrotropin-releasing hormone-stimulated inositol phosphate production in clonal rat pituitary (GH4C1) cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8349615&form=6&db=m Stimulation of neutrophils with a chemoattractant activates several novel protein kinases that can catalyze the phosphorylation of peptides derived from the 47-kDa protein component of the phagocyte oxidase and myristoylated alanine-rich C kinase substrate. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8349672&form=6&db=m Nitric oxide-independent, thiol-associated ADP-ribosylation inactivates aldehyde dehydrogenase. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8350265&form=6&db=m Activation of muscarinic K+ current in guinea-pig atrial myocytes by a serum factor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8351284&form=6&db=m Effects of cholera and pertussis toxins on prolactin stimulation of lactose synthesis and ornithine decarboxylase activity in mouse mammary gland explants. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8356092&form=6&db=m Activation of mast cell K+ channels through multiple G protein-linked receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8358567&form=6&db=m Intracellular cross-talk between receptors coupled to phospholipase C via pertussis toxin-sensitive and insensitive G-proteins in DDT1MF-2 cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8358772&form=6&db=m Sphingosine mobilizes intracellular calcium in human neutrophils. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8359240&form=6&db=m A pertussis toxin-sensitive G protein mediates inhibition by morphine of spontaneous electrical activity of oxytocin neurones in anaesthetized rats. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8360671&form=6&db=m Muscarine receptors regulating electrically evoked release of acetylcholine in hippocampus are linked to pertussis toxin-sensitive G proteins but not to adenylate cyclase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8363615&form=6&db=m GTP-binding protein couples with metabotropic glutamate receptor in bovine retinal on-bipolar cell. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8366123&form=6&db=m Signaling events initiated by transforming growth factor-beta 1 that require Gi alpha 1. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8368374&form=6&db=m Pertussis toxin-induced ADP ribosylation of inhibitor G proteins alters vagal control of heart rate in vivo. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8371711&form=6&db=m Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8371717&form=6&db=m Transfected D2 short dopamine receptors inhibit voltage-dependent potassium current in neuroblastoma x glioma hybrid (NG108-15) cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8373359&form=6&db=m Pancreastatin increases free cytosolic Ca2+ in rat hepatocytes, involving both pertussis-toxin-sensitive and -insensitive mechanisms. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8373724&form=6&db=m Receptor-stimulated dissociation of GTP[S] from Gi-proteins in membranes of HL-60 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8374090&form=6&db=m Pertussis toxin-induced redistribution of cortical actomyosin and inhibition of phagocytosis in rat Kupffer cells. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8374774&form=6&db=m Modification of morphine-induced locomotor activity by pertussis toxin: biochemical and behavioral studies in mice. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8377218&form=6&db=m Opioid effects on contractility, Ca(2+)-transients and intracellular pH in cultured cardiac myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8377845&form=6&db=m Effect of pretreatment with pertussis toxin on the development of physical dependence on morphine. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8380059&form=6&db=m Phosphoinositide metabolism in a polyoma-BK-virus-transformed pancreatic islet cell line: evidence for constitutively activated phospholipase C. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8380261&form=6&db=m Selective A2-adenosine receptor agonists do not alter action potential duration, twitch shortening, or cAMP accumulation in guinea pig, rat, or rabbit isolated ventricular myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8380866&form=6&db=m Buprenorphine prevents and reverses the expression of chronic etorphine-induced sensitization of adenylyl cyclase in SK-N-SH human neuroblastoma cells. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8380931&form=6&db=m Mechanism of lipid mobilization associated with cancer cachexia: interaction between the polyunsaturated fatty acid, eicosapentaenoic acid, and inhibitory guanine nucleotide-regulatory protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8380997&form=6&db=m Differential cholera-toxin- and pertussis-toxin-catalysed ADP-ribosylation of G-proteins coupled to formyl-peptide and leukotriene B4 receptors. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8381010&form=6&db=m Crystal-induced neutrophil activation. II. Evidence for the activation of a phosphatidylcholine-specific phospholipase D. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8381320&form=6&db=m Histamine H1-receptor-mediated inositol phospholipid hydrolysis in DDT1MF-2 cells: agonist and antagonist properties. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8381358&form=6&db=m Cholera toxin but not pertussis toxin inhibits angiotensin II-enhanced contractions in the rat portal vein. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8381413&form=6&db=m Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8381456&form=6&db=m Characterization of the gonadotrophin-releasing hormone receptor in alpha T3-1 pituitary gonadotroph cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8381630&form=6&db=m Pertussis toxin augments beta-adrenergic relaxation of muscarinic contraction in canine trachealis. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8381837&form=6&db=m IL-8 induces the locomotion of human IL-2-activated natural killer cells. Involvement of a guanine nucleotide binding (Go) protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8381927&form=6&db=m Regional effects of pertussis toxin in vivo and in vitro on GABAB receptor binding in rat brain. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8382084&form=6&db=m Adenosine inhibits fMLP-stimulated adherence and superoxide anion generation by human neutrophils at an early step in signal transduction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8382086&form=6&db=m Functional interaction of prostaglandin E receptor EP3 subtype with guanine nucleotide-binding proteins, showing low-affinity ligand binding. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8382264&form=6&db=m Additive induction of Egr-1 (zif/268) mRNA expression in neuroblastoma x glioma hybrid NG108-15 cells via cholinergic muscarinic, alpha 2-adrenergic, and bradykinin receptors. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8382284&form=6&db=m B1 and B2 kinin receptors on cultured rabbit superior mesenteric artery smooth muscle cells: receptor-specific stimulation of inositol phosphate formation and arachidonic acid release by des-Arg9-bradykinin and bradykinin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8382416&form=6&db=m Adjuvant action of cholera toxin and pertussis toxin in the induction of IgA antibody response to orally administered antigen. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8382479&form=6&db=m Enkephalin activates the phospholipase C/Ca2+ system through cross-talk between opioid receptors and P2-purinergic or bradykinin receptors in NG 108-15 cells. A permissive role for pertussis toxin-sensitive G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8382482&form=6&db=m Thrombin receptor agonist peptide induction of mitogenesis in CCL39 cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8382499&form=6&db=m mu and delta opioid receptors differentially couple to G protein subtypes in membranes of human neuroblastoma SH-SY5Y cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8382563&form=6&db=m Indications from Mn-quenching of Fura-2 fluorescence in melanotrophs that dopamine and baclofen close Ca channels that are spontaneously open but not those opened by high [K+]O; and that Cd preferentially blocks the latter. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8382633&form=6&db=m Functional regulation of GTP-binding protein coupled to insulin-like growth factor-I receptor by lithium during G1 phase of the rat thyroid cell cycle. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8382638&form=6&db=m Corticotropin-releasing factor: an antireproductive hormone of the testis. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8382734&form=6&db=m Dihydropyridine- and omega-conotoxin-sensitive Ca2+ currents in cerebellar neurons: persistent block of L-type channels by a pertussis toxin-sensitive G-protein. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383056&form=6&db=m Impaired G-proteins and cyclic nucleotide phosphodiesterase activity in T-lymphocytes from patients with sarcoidosis. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383426&form=6&db=m Human plasmin induces a receptor-mediated arachidonate release coupled with G proteins in endothelial cells. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383428&form=6&db=m G protein activation inhibits amiloride-blockable highly selective sodium channels in A6 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383449&form=6&db=m Protein kinase C inhibits arginine vasopressin-stimulated cAMP accumulation via a Gi-dependent mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383574&form=6&db=m Dibutyryl cyclic AMP-induced morphological differentiation of rat brain astrocytes increases alpha 1-adrenoceptor induced phosphoinositide breakdown by a mechanism involving protein synthesis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383601&form=6&db=m Presynaptic inhibitory effect of baclofen on hippocampal inhibitory synaptic transmission involves a pertussis toxin-sensitive G-protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383774&form=6&db=m Modulation of voltage-activated Ca currents by pain-inducing agents in a dorsal root ganglion neuronal line, F-11. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383803&form=6&db=m Ca2+ inhibition of beta-adrenergic receptor- and forskolin-stimulated cAMP accumulation in C6-2B rat glioma cells is independent of protein kinase C. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383804&form=6&db=m Receptor mechanisms of opioid tolerance in SH-SY5Y human neural cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383822&form=6&db=m Pertussis toxin treatment increases glutamate release and dihydropyridine binding sites in cultured rat cerebellar granule neurons. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383979&form=6&db=m Use of pertussis toxin to investigate the mechanism of action of prostaglandin F2 alpha on the corpus luteum in sheep. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8384003&form=6&db=m Calcium- and G-protein-dependent activation of arachidonic acid release by concanavalin-A-stimulated mouse macrophages. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8384043&form=6&db=m Identification of cannabinoid receptors in cultures of rat cerebellar granule cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8384085&form=6&db=m Human monocytes respond to leukotriene B4 with a transient increase in cytosolic calcium. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8384160&form=6&db=m Purinergic P2Y receptors on astrocytes are directly coupled to phospholipase A2. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8384252&form=6&db=m kappa-Opioid agonist modulation of [3H]thymidine incorporation into DNA: evidence for the involvement of pertussis toxin-sensitive G protein-coupled phosphoinositide turnover. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8384279&form=6&db=m Parathyroid hormone raises cytosolic calcium in pancreatic islets: study on mechanisms. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8384423&form=6&db=m Effects of exercise on myocardial adenylate cyclase and Gi alpha expression in senescence. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8385110&form=6&db=m Coupling of the expressed alpha 1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes. The role of Go. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8385355&form=6&db=m Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8385589&form=6&db=m The effects of pertussis toxin on vasoconstrictor and vasodilator agents in the pithed rat may not be an indicator of G-protein receptor coupling. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8386215&form=6&db=m Oxytocin-stimulated phosphoinositide hydrolysis in human myometrial cells: involvement of pertussis toxin-sensitive and -insensitive G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8386346&form=6&db=m Inhibitory glutamate response on cyclic AMP formation in cultured astrocytes. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8386608&form=6&db=m Cholera toxin and pertussis toxin provoke differential effects on luteinizing hormone release, inositol phosphate production, and gonadotropin-releasing hormone (GnRH) receptor binding in the gonadotrope: evidence for multiple guanyl nucleotide binding proteins in GnRH action. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8386609&form=6&db=m A cholera toxin-sensitive guanyl nucleotide binding protein mediates the movement of pituitary luteinizing hormone into a releasable pool: loss of this event is associated with the onset of homologous desensitization to gonadotropin-releasing hormone. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8386613&form=6&db=m Spontaneous cytosolic calcium pulsing detected in Xenopus melanotrophs: modulation by secreto-inhibitory and stimulant ligands. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8386624&form=6&db=m Stimulatory and inhibitory guanine-nucleotide-binding regulatory protein involvement in stimulation of arachidonic-acid release by N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor from guinea-pig alveolar macrophages. Differential receptor/G-protein interaction assessed by pertussis and cholera toxins. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8386968&form=6&db=m mu and delta opioid agonists at low concentrations decrease voltage-dependent K+ currents in F11 neuroblastoma x DRG neuron hybrid cells via cholera toxin-sensitive receptors. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8387027&form=6&db=m Estradiol up-regulates the stimulatory GTP-binding protein expression in the MCF-7 human mammary carcinoma cell line. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8387140&form=6&db=m Platelet activating factor stimulates a receptor-coupled membrane GTPase in guinea pig eosinophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8387292&form=6&db=m Rapid degradation of NAD by retinoic acid-differentiated HL-60 granulocyte membranes prevents ADP ribosylation. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8387668&form=6&db=m Mechanism of muscarinic control of the high-threshold calcium current in rabbit sino-atrial node myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8388325&form=6&db=m Dual effect of thrombin on voltage-dependent Ca2+ channels of portal vein smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8388420&form=6&db=m Ligation of CD23 triggers cyclic AMP generation in human B lymphocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8388703&form=6&db=m Mitogenic effects of pertussis toxin-sensitive G-protein alpha subunits: the mitogenic action of alpha i2 in NIH 3T3 cells is mimicked by alpha i1, but not alpha i3. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8388986&form=6&db=m delta-Opioid receptor activates cAMP phosphodiesterase activities in neuroblastoma x glioma NG108-15 hybrid cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8389133&form=6&db=m Potentiation by cholera toxin of bradykinin-induced inositol phosphate production in the osteoblast-like cell line MC3T3-E1. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8389485&form=6&db=m Photosensory transduction in ciliates. II. Possible role of G-protein and cGMP in Stentor coeruleus. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8389957&form=6&db=m Temperature-dependent stimulation and inhibition of adenylate cyclase by Aplysia bag cell peptides. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8390030&form=6&db=m Role of intracellular Ca(2+)-stores in the 5-hydroxytryptamine-induced Ca(2+)-current inhibition in NG108-15 hybrid cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8390132&form=6&db=m Pertussis toxin-sensitive activation of phospholipase A2 can be resolved from phosphoinositidase C in primary cultures of mouse osteoblasts using indomethacin. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8390669&form=6&db=m Alpha 2-adrenergic inhibition of Cl- transport by opercular epithelium is mediated by intracellular Ca2+. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8390863&form=6&db=m Cellular signalling by lipoproteins in cultured smooth muscle cells from spontaneously hypertensive rats. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8391006&form=6&db=m Mechanism and regulation of neutrophil priming by platelet-activating factor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8391194&form=6&db=m Interleukin-1 stimulates the release of interleukin-6 from cultured human pituitary adenoma cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8391400&form=6&db=m Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8391421&form=6&db=m Cross-talk between Ca2+ influx and phosphoinositide hydrolysis by extracellular adenosine triphosphate in rat PC12 pheochromocytoma cells. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8391658&form=6&db=m Modulation of neutrophil migration by captopril. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8391681&form=6&db=m Serum contains a potent factor that decreases beta-adrenergic receptor-stimulated L-type Ca2+ current in cardiac myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8392027&form=6&db=m Adenylate cyclase activity in microdissected rat liver tissue: periportal to pericentral activity gradient. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8392058&form=6&db=m 5-hydroxyicosatetraenoate stimulates neutrophils by a stereospecific, G protein-linked mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8392092&form=6&db=m Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8392134&form=6&db=m Age-related regional sensitivity to pertussis toxin-mediated reduction in GABAB receptor binding in rat brain. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8392194&form=6&db=m Gi2 and protein kinase C are required for thyrotropin-releasing hormone-induced stimulation of voltage-dependent Ca2+ channels in rat pituitary GH3 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8392341&form=6&db=m Effect of delta-opioid antagonists on the functional coupling between opioid receptors and G-proteins in rat brain membranes. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8392381&form=6&db=m Neutrophil chemotaxis induced by the diacylglycerol kinase inhibitor R59022. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8392428&form=6&db=m The role of G protein in muscarinic depolarization near resting potential in cultured hippocampal neurons. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8392538&form=6&db=m Modulation of calcium currents by a metabotropic glutamate receptor involves fast and slow kinetic components in cultured hippocampal neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8392552&form=6&db=m The mechanism for the rapid desensitization in bradykinin-stimulated inositol monophosphate production in NG108-15 cells involves interaction of a single receptor with multiple signaling pathways. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8392573&form=6&db=m Guanine nucleotide binding proteins mediate D2 dopamine receptor activation of a potassium channel in rat lactotrophs. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8392802&form=6&db=m Effect of heat shock, [Ca2+]i, and cAMP on inositol trisphosphate in human epidermoid A-431 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8392842&form=6&db=m Autocrine motility factor is a growth factor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8392932&form=6&db=m Conserved transducer coupling but different effector linkage upon expression of the myeloid fMet-Leu-Phe receptor in insulin secreting cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8393006&form=6&db=m DNA topology affects transcriptional regulation of the pertussis toxin gene of Bordetella pertussis in Escherichia coli and in vitro. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8393196&form=6&db=m Pertussis toxin sensitive photoaggregation of pigment in isolated Xenopus tail-fin melanophores. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8393279&form=6&db=m Vasopressin and protein kinase A activate G protein-sensitive epithelial Na+ channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8393290&form=6&db=m Mechanism of the prolactin rebound after dopamine withdrawal in rat pituitary cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8393356&form=6&db=m Lipoxin A4 induces hyperadhesiveness in human endothelial cells for neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8393524&form=6&db=m Comparison of alpha 1-adrenergic receptor subtypes and signal transduction in SK-N-MC and NB41A3 neuronal cell lines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8393597&form=6&db=m Involvement of intracellular Ca2+ release mechanism in adenosine-induced cardiac Ca2+ current inhibition. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8393830&form=6&db=m Protein kinase C inhibits cyclic adenosine monophosphate generation by histamine and truncated glucagon like peptide 1 in the human gastric cancer cell line HGT-1. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8393865&form=6&db=m Constitutively active mutants of the alpha 2-adrenergic receptor. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8394332&form=6&db=m Synthesis of phosphatidylinositol 3,4,5-trisphosphate in permeabilized neutrophils regulated by receptors and G-proteins. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8394363&form=6&db=m Transfection of NG108-15 cells with antisense opioid-binding cell adhesion molecule cDNA alters opioid receptor-G-protein interaction. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8394424&form=6&db=m Mechanism of the effects of acetylcholine on the contractile properties and Ca2+ transients in ferret ventricular muscles. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8394594&form=6&db=m Neuromedin-B receptor transfected BALB/3T3 cells: signal transduction and effects of ectopic receptor expression on cell growth. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8394819&form=6&db=m Pertussis toxin-sensitive inhibition of glucagon-like peptide 1-stimulated acid production by epidermal growth factor and transforming growth factor alpha in rat parietal cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8394913&form=6&db=m 5-Hydroxytryptamine1-like receptors linked to increases in intracellular calcium concentration and inhibition of cyclic AMP accumulation in cultured vascular smooth muscle cells derived from bovine basilar artery. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8395053&form=6&db=m Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8395285&form=6&db=m Excitatory amino acid receptor-stimulated phosphoinositide turnover in primary cerebrocortical cultures. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8395419&form=6&db=m Cycloheximide abolishes pertussis toxin induced increase in glutamate release from cerebellar granule neurones. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8395543&form=6&db=m Isoproterenol and GTP gamma S inhibit L-type calcium channels of differentiating rat skeletal muscle cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8396073&form=6&db=m Suppression of lymphocyte adenosine 3':5'-cyclic monophosphate (cAMP) by delta-9-tetrahydrocannabinol. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8396128&form=6&db=m Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8396718&form=6&db=m Dual coupling of cloned human 5-hydroxytryptamine1D alpha and 5-hydroxytryptamine1D beta receptors stably expressed in murine fibroblasts: inhibition of adenylate cyclase and elevation of intracellular calcium concentrations via pertussis toxin-sensitive G protein(s). causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8396963&form=6&db=m Endothelin receptors in rat cerebellum: activation of phosphoinositide hydrolysis is transduced by multiple G-proteins. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8396964&form=6&db=m An arginine residue is the site of receptor-stimulated, cholera toxin-catalysed ADP-ribosylation of pertussis toxin-sensitive G-proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8397045&form=6&db=m Further characterization of 5-HT- and 5-HT3 receptor agonists'-stimulated phosphoinositol phosphates accumulation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8397190&form=6&db=m Receptor-evoked Cl- current in Xenopus oocytes is mediated through a beta-type phospholipase C. Cloning of a new form of the enzyme. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8397209&form=6&db=m Peptide YY receptors in the proximal tubule PKSV-PCT cell line derived from transgenic mice. Relation with cell growth. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8397512&form=6&db=m Interferon-gamma-stimulated and GTP-binding-proteins-mediated phospholipase A2 activation in human neuroblasts. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8398979&form=6&db=m Guanine nucleotide binding proteins mediate the chemotactic signal of transforming growth factor-beta 1 in rat IL-2 activated natural killer cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8400301&form=6&db=m Signal pathway regulation of interleukin-8-induced actin polymerization in neutrophils. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8400894&form=6&db=m Lymphocyte proliferation induced by pertussis toxin utilizes a pathway parallel to transforming growth factor-beta-sensitive growth. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8403372&form=6&db=m Modulation of neuropeptide Y expression in rat brain neuronal cultures. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8404642&form=6&db=m The effect of cholecystokinin on intracellular Ca2+, membrane-associated protein kinase-C activity, and progesterone production in chicken granulosa cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8405917&form=6&db=m Effects of pertussis toxin on intraocular pressure and adenylate cyclase activity of ciliary processes in rabbits. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8406362&form=6&db=m Stimulation of mono-ADP ribosylation in rat liver plasma membranes after long-term alcohol intake. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8406588&form=6&db=m Requirements for Langerhans' cell depletion following in vitro exposure of murine skin to ultraviolet-B. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8406793&form=6&db=m Bordetella pertussis induces apoptosis in macrophages: role of adenylate cyclase-hemolysin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8406794&form=6&db=m Virulence of Bordetella bronchiseptica: role of adenylate cyclase-hemolysin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8406812&form=6&db=m Pertussis toxin-induced alterations of murine hepatic drug metabolism following administration of diphtheria and tetanus toxoids and pertussis vaccine adsorbed. diagnostic usage,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8407844&form=6&db=m A phase variant of Bordetella pertussis with a mutation in a new locus involved in the regulation of pertussis toxin and adenylate cyclase toxin expression. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8408028&form=6&db=m A deletion mutation in the third cytoplasmic loop of the mouse m1 muscarinic acetylcholine receptor unmasks cryptic G-protein binding sites. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8408097&form=6&db=m Pertussis toxin sensitive effects of dipyridamole on rat atrial rate. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8410161&form=6&db=m Adenosine modulates voltage-gated Ca2+ channels in adult rat sympathetic neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8410690&form=6&db=m M2 muscarinic receptor-mediated inhibition of the Ca2+ current in rat magnocellular cholinergic basal forebrain neurones. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8411191&form=6&db=m Pertussis toxin unmasks stimulatory myocardial A2-adenosine receptors on ventricular cardiomyocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8416406&form=6&db=m Adult immunization with acellular pertussis vaccine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8418057&form=6&db=m Binding of pertussis toxin to lipid vesicles containing glycolipids. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8418210&form=6&db=m Site-specific alterations in the B oligomer that affect receptor-binding activities and mitogenicity of pertussis toxin. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8418498&form=6&db=m Mediation by G proteins of signals that cause collapse of growth cones. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8418742&form=6&db=m Halothane myocardial depression: interactions with the adenylate cyclase system. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8418893&form=6&db=m Identification of heterotrimeric and low molecular weight GTP-binding proteins in rabbit skeletal muscle longitudinal sarcoplasmic reticulum. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8418894&form=6&db=m Strontium and barium induce exocytosis in electropermeabilized neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8419127&form=6&db=m Opposing influences of dexamethasone and retinoic acid on adenylate cyclase activity in ROS 17/2.8 cells. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8419342&form=6&db=m Mutational analysis of G protein alpha subunit G(o) alpha expressed in Escherichia coli. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8419348&form=6&db=m Lipopolysaccharide interaction with S2 subunit of pertussis toxin. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8419538&form=6&db=m Ca2+ release from inositol 1,4,5-trisphosphate-sensitive Ca2+ store by antidepressant drugs in cultured neurons of rat frontal cortex. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8420805&form=6&db=m Characterization of metabotropic glutamate receptors coupled to a pertussis toxin sensitive G-protein in bovine brain coated vesicles. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8422945&form=6&db=m Thromboxane A2 analogue U 46619 enhances tumour cell proliferation in HeLa cells via specific receptors which are apparently distinct from TXA2 receptors on human platelets. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8423077&form=6&db=m Bordetella pertussis and Bordetella parapertussis: two immunologically distinct species. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8423087&form=6&db=m Antibody responses in the serum and respiratory tract of mice following oral vaccination with liposomes coated with filamentous hemagglutinin and pertussis toxoid. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8423328&form=6&db=m Pertussis toxin-sensitive factor differentially regulates lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production in mouse peritoneal macrophages. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8423550&form=6&db=m Cholinergic M2 muscarinic receptor-mediated inhibition of endogenous noradrenaline release from the isolated vascularly perfused rat stomach. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8426770&form=6&db=m Comparison of acellular pertussis vaccine with whole cell vaccine as a booster in children 15 to 18 months and 4 to 6 years of age. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8427592&form=6&db=m Stimulation of a Gs-like G protein in the osteoclast inhibits bone resorption but enhances tartrate-resistant acid phosphatase secretion. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8427704&form=6&db=m Involvement of a signal transduction mechanism in ATP-induced mucin release from cultured airway goblet cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8428218&form=6&db=m Adenosine A1-receptor stimulated increases in intracellular calcium in the smooth muscle cell line, DDT1MF-2. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8428935&form=6&db=m Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8429049&form=6&db=m Epidermal growth factor-mediated signaling of G(i)-protein to activation of phospholipases in rat-cultured hepatocytes. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8430774&form=6&db=m Adenosine stimulation of AMP deaminase activity in adult rat cardiac myocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8431980&form=6&db=m Heterogeneity of ATP receptors in aortic endothelial cells. Involvement of P2y and P2u receptors in inositol phosphate response. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8431982&form=6&db=m Acetylcholine reversal of isoproterenol-stimulated sodium currents in rabbit ventricular myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8432984&form=6&db=m The rabbit neutrophil N-formyl peptide receptor. cDNA cloning, expression, and structure/function implications. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8434024&form=6&db=m Stimulation of human thyroid growth via the inhibitory guanine nucleotide binding (G) protein Gi: constitutive expression of the G-protein alpha subunit Gi alpha-1 in autonomous adenoma. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8436602&form=6&db=m Deregulation of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor in murine macrophage cell line J774A.1. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8437887&form=6&db=m Agonist-induced inhibition of inositol-trisphosphate-activated IK(Ca) in NG108-15 neuroblastoma hybrid cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8438810&form=6&db=m Comparison of the safety and immunogenicity of acellular (BIKEN) and whole-cell pertussis vaccines in 15- to 20-month-old children. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8438811&form=6&db=m Comparison of a diphtheria and tetanus toxoids and bicomponent acellular pertussis vaccine with diphtheria and tetanus toxoids and whole-cell pertussis vaccine in infants. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8440945&form=6&db=m Interferon-gamma levels in serum and bronchoalveolar lavage fluid of mice infected with Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8442955&form=6&db=m Differential sensitivity of progesterone- and zona pellucida-induced acrosome reactions to pertussis toxin. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8443180&form=6&db=m Synthesis and characterization of fluorescently labeled bovine brain G protein subunits. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8443236&form=6&db=m Involvement of tyrosine kinase in growth factor-induced phospholipase C activation in NIH3T3 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8447160&form=6&db=m Quantification of pertussis toxin, filamentous haemagglutinin, 69 kDa outer membrane protein, agglutinogens 2 and 3 and lipopolysaccharide in the Danish whole-cell pertussis vaccine. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8448011&form=6&db=m Properties of diazoxide and cromakalim-induced activation of potassium channels in cultured rat and RINm5F insulin-secreting cells; effects of GTP. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8448592&form=6&db=m Pharmacological differentiation by pertussis toxin of the in vivo acute responses to fMLP and PAF in guinea-pig lungs. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8449688&form=6&db=m Experimental autoimmune anterior uveitis. The preparation of uveitogenic ocular melanin. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8449930&form=6&db=m Transfected m2 muscarinic acetylcholine receptors couple to G alpha i2 and G alpha i3 in Chinese hamster ovary cells. Activation and desensitization of the phospholipase C signaling pathway. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8450563&form=6&db=m Identification of neuropeptide Y receptors in cultured astrocytes from neonatal rat brain. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8450714&form=6&db=m Characterization of vasopressin-mediated GSH efflux from Hep G2 cells: significance of protein kinase C. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8452756&form=6&db=m Differential effects of fluoride and a non-hydrolysable GTP analogue on adenylate cyclase and G-proteins in Ceratitis capitata neural tissue. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8452871&form=6&db=m Stimulation of glucose incorporation into glycogen by E-series prostaglandins in cultured rat hepatocytes. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8455595&form=6&db=m The product of a novel growth factor-activated gene, fic, is a biologically active "C-C"-type cytokine. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8456975&form=6&db=m Lysophosphatidylcholine modifies G protein-dependent signaling in porcine endothelial cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8458019&form=6&db=m Homologous sensitisation of embryonic chick atrial myocytes to adenosine: mediation by adenosine A1 receptor and guanine nucleotide binding protein. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8458024&form=6&db=m Endogenous adenosine, A1 adenosine receptor, and pertussis toxin sensitive guanine nucleotide binding protein mediate hypoxia induced AV nodal conduction block in guinea pig heart in vivo. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8458876&form=6&db=m Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8460710&form=6&db=m Pertussis toxin attenuates platelet-activating factor-induced pulmonary hemodynamic alterations in pigs. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8460998&form=6&db=m P2 purinergic agonists and 12-O-tetradecanoylphorbol-13-acetate, as well as protein kinase A activators, stimulate thyroglobulin secretion in FRTL-5 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8462454&form=6&db=m The involvement of inositol phosphoglycan mediators in the modulation of steroidogenesis by insulin and insulin-like growth factor-I. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8462467&form=6&db=m The stimulatory effect of insulin on diacylglycerol generation in adipocyte membranes from ob/ob mice is impaired by growth hormone. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8464662&form=6&db=m Safety and immunogenicity of an acellular pertussis vaccine booster in 15- to 20-month-old children previously immunized with acellular or whole-cell pertussis vaccine as infants. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8464913&form=6&db=m Molecular characterization of an operon required for pertussis toxin secretion. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8469373&form=6&db=m Neuropeptide Y stimulates DNA synthesis in vascular smooth muscle cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8470429&form=6&db=m Serological correlates in whooping cough. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8470432&form=6&db=m Proliferative responses to purified and fractionated Bordetella pertussis antigens in mice immunized with whole-cell pertussis vaccine. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8471065&form=6&db=m Tissue- and subunit-specific regulation of G-protein expression by hypo- and hyperthyroidism. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8473054&form=6&db=m Granulocyte-macrophage colony-stimulating factor induces human melanoma-cell migration. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8473313&form=6&db=m G protein-mediated inhibition of phospholipase C activity in a solubilized membrane preparation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8474003&form=6&db=m Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: II. Effect of pertussis and cholera toxins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8475060&form=6&db=m Calcium influx mediated by the Escherichia coli heat-stable enterotoxin B (STB). therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8475118&form=6&db=m Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8478596&form=6&db=m Biochemical and immunochemical localization of GTP-binding proteins in the rat ileal enterocyte. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8479122&form=6&db=m Bilateral ureteral obstruction alters levels of the G-protein subunits G alpha s and G alpha q/11. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8482512&form=6&db=m The complex interaction of ATP and UTP with isolated hepatocytes. How many receptors? unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8482923&form=6&db=m Transmembrane signaling pathways involved in phagocytosis and associated activation of NADPH oxidase mediated by Fc gamma Rs in human neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8483621&form=6&db=m How common is whooping cough in a nonvaccinating country? diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8484719&form=6&db=m G-protein from Medicago sativa: functional association to photoreceptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8488807&form=6&db=m Unrecognized pertussis infection in adolescents. diagnostic usage,ongoing research,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8489520&form=6&db=m The role of Gi and the membrane-fluidizing agent benzyl alcohol in modulating the hysteretic activation of human platelet adenylate cyclase by guanylyl 5'-imidodiphosphate. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8492147&form=6&db=m Serotonin-operated potassium current in CA1 neurons dissociated from rat hippocampus. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8499226&form=6&db=m Pertussis toxin expression in Drosophila alters the visual response and blocks eating behaviour. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8499896&form=6&db=m Antibodies to Bordetella pertussis adenylate cyclase toxin in neonatal and maternal sera. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8500137&form=6&db=m Calcium mobilization and cell proliferation activated by extracellular ATP in human ovarian tumour cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8500874&form=6&db=m Characterization of pertussis toxin analogs containing mutations in B-oligomer subunits. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8502126&form=6&db=m Neuropeptide Y inhibits pertussis toxin-catalyzed ADP-ribosylation in bovine adrenal chromaffin cell membranes. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8502521&form=6&db=m Severe reactions associated with diphtheria-tetanus-pertussis vaccine: detailed study of children with seizures, hypotonic-hyporesponsive episodes, high fevers, and persistent crying. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8504738&form=6&db=m Opposite, phase-dependent effects of 3,4,5-trimethoxybenzoic acid 8-(diethylamino) octyl ester or tetracaine on islet function during three phases of glucose-stimulated insulin secretion. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8509398&form=6&db=m Molecular characterization of the in vitro activation of pertussis toxin by ATP. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8510172&form=6&db=m Pretreatment with pertussis toxin blocks the protective effects of preconditioning: evidence for a G-protein mechanism. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8510384&form=6&db=m Protein intake affects levels of G-protein subunits G alpha i2, G alpha i3, and G beta in rat glomerular membranes. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8512552&form=6&db=m Muscarinic receptors stimulate Ca2+ influx via phospholipase A2 pathway in ileal smooth muscles. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8513133&form=6&db=m Carboxyl domain of glutamate receptor directs its coupling to metabolic pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8514386&form=6&db=m Enhancement of interleukin-4 production by pertussis toxin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8515284&form=6&db=m Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8515432&form=6&db=m A Gq-type G protein couples muscarinic receptors to inositol phosphate and calcium signaling in exocrine cells from the avian salt gland. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8515746&form=6&db=m [Features of expression of the pertussis toxin operon under the control of its own and heterologous promotors in Bordetella bronchiseptica cells] ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8519595&form=6&db=m Adenosine receptor activation potentiates phosphoinositide hydrolysis and arachidonic acid release in DDT1-MF2 cells: putative interrelations. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8521911&form=6&db=m Multiple mechanisms of bradykinin-induced contraction in rat and guinea pig smooth muscles in vitro. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8522378&form=6&db=m Serum antibodies to the components of diphtheria-tetanus-pertussis vaccine in Polish children related to vaccination status. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8522958&form=6&db=m Dopaminergic inhibition of catecholamine secretion from chromaffin cells: evidence that inhibition is mediated by D4 and D5 dopamine receptors. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8524961&form=6&db=m Reorientation of macrophage mediator production in endotoxin tolerance. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8525456&form=6&db=m Regulation and functional characterization of a rat recombinant dopamine D3 receptor. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8526880&form=6&db=m Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8526925&form=6&db=m The Ca(2+)-dependent activation by fluoride of human red cell membrane sodium permeability: evidence for a chemically activated tetrodotoxin-sensitive Na+ channel. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8526939&form=6&db=m Activation of phospholipase A2 by the human endothelin receptor in Chinese hamster ovary cells involves Gi protein-mediated calcium influx. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8527486&form=6&db=m A proposed mechanism of ADP-ribosylation catalyzed by the pertussis toxin S1 subunit. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8528894&form=6&db=m Modification of cholinergic-mediated cellular transmembrane signals by the interaction of human chagasic IgG with cardiac muscarinic receptors. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8529406&form=6&db=m Immunohistochemical studies on melanin associated antigen (MAA) induced experimental autoimmune anterior uveitis (EAAU). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8530415&form=6&db=m Identification of two isoforms of mouse neuropeptide Y-Y1 receptor generated by alternative splicing. Isolation, genomic structure, and functional expression of the receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8531231&form=6&db=m GABA-induced motility of spinal neuroblasts develops along a ventrodorsal gradient and can be mimicked by agonists of GABAA and GABAB receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8532174&form=6&db=m Modulation of calcium channels by metabotropic glutamate receptors in cerebellar granule cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8532175&form=6&db=m Metabotropic glutamate receptor modulation of synaptic transmission in corticostriatal co-cultures: role of calcium influx. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8532582&form=6&db=m beta-Amyloid peptide, substance P, and SEC receptor ligand activate cytoplasmic Ca2+ in neutrophil-like HL-60 cells: effect of chemotactic peptide antagonist BocMLF. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8533580&form=6&db=m Immunogenicity and reactogenicity of the component acellular pertussis vaccine produced by a combination of column purified pertussis toxin and filamentous haemagglutinin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8536620&form=6&db=m Effects of extracellular nucleotides in the pituitary: adenosine triphosphate receptor-mediated intracellular responses in gonadotrope-derived alpha T3-1 cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8537304&form=6&db=m Enhancement of stress-induced synthesis of stress proteins by mastoparan in C6 rat glioma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8538158&form=6&db=m Octreotide inhibition of serotonin-induced ileal chloride secretion. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8538704&form=6&db=m A controlled trial of two acellular vaccines and one whole-cell vaccine against pertussis. Progetto Pertosse Working Group. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8538992&form=6&db=m Inhibition of platelet-activating factor-induced retinal impairments by cholera and pertussis toxins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8539553&form=6&db=m Response and decline of serum IgG antibodies to pertussis toxin, filamentous hemagglutinin and pertactin in children with pertussis. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8541554&form=6&db=m Analysis of signaling events associated with activation of neutrophil superoxide anion production by eosinophil granule major basic protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8543566&form=6&db=m Effects of protein kinase C and A activation on ATP-stimulated release of [3H]noradrenaline from PC12 cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8544120&form=6&db=m Control of the amiloride-sensitive Na+ current in mouse salivary ducts by intracellular anions is mediated by a G protein. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8544988&form=6&db=m Norepinephrine modulates high voltage-activated calcium channels in freshly dissociated rat nucleus tractus solitarii neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8546817&form=6&db=m Transcriptional regulation of Na/K-ATPase by corticosteroids, glycyrrhetinic acid and second messenger pathways in rat kidney epithelial cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8550212&form=6&db=m Pertussis toxin-catalyzed ADP-ribosylation of Gi-2 and Gi-3 in CHO cells is modulated by inhibitors of intracellular trafficking. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8552586&form=6&db=m The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8554311&form=6&db=m G-protein-sensitive guanylyl cyclase activity associated with plasma membranes. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8554517&form=6&db=m Cross-talk between glucagon- and adenosine-mediated signalling systems in rat hepatocytes: effects on cyclic AMP-phosphodiesterase activity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8554738&form=6&db=m Sodium ions attenuate the inhibitory effects of neuropeptide Y on norepinephrine release in rat hypothalamus. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8556512&form=6&db=m Human antibody response to the B oligomer of pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8557239&form=6&db=m Adenosine A1-receptors inhibit cAMP and Ca2+ mediated calcitonin secretion in C-cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8558248&form=6&db=m Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8558422&form=6&db=m Beta adrenergic receptor activation attenuates the generation of inositol phosphates in the pregnant rat myometrium. Correlation with inhibition of Ca++ influx, a cAMP-independent mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8559630&form=6&db=m Acellular pertussis vaccine as a booster dose for seventeen- to nineteen-month-old children immunized with either whole cell or acellular pertussis vaccine at two, four and six months of age. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8561772&form=6&db=m Regulation of the potassium current and cytosolic Ca2+ release induced by 2-methylthio ATP in hippocampal neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8561808&form=6&db=m Regulation of the serum-activated Ca(2+)-dependent chloride channel in Xenopus oocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8562311&form=6&db=m Role of tyrosine kinase in insulin release in an insulin secreting cell line (INS-1). therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8564200&form=6&db=m Synergy between the inositol phosphate responses to transfected human adenosine A1-receptors and constitutive P2-purinoceptors in CHO-K1 cells. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8564206&form=6&db=m The mechanism of action of alpha 2-adrenoceptors in human isolated subcutaneous resistance arteries. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8564258&form=6&db=m Stimulation by endothelin-1 of mitogen-activated protein kinases and DNA synthesis in bovine tracheal smooth muscle cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8566159&form=6&db=m Mystixin-7 and mystixin-11 increase cytosolic free Ca2+ and inositol trisphosphates in human A-431 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8566174&form=6&db=m The inositol phosphate response to thrombin in rat right atria differs from the response to noradrenaline. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8567722&form=6&db=m Lysophosphatidic acid and bFGF control different modes in proliferating myoblasts. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8568234&form=6&db=m Early signal transduction by the receptor to the chemokine monocyte chemotactic protein-1 in a murine T cell hybrid. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8568512&form=6&db=m Identification of the border between fibronectin type III homologous repeats 2 and 3 of the neural cell adhesion molecule L1 as a neurite outgrowth promoting and signal transducing domain. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8568944&form=6&db=m Blockade of K+ channels induced by AMPA/kainate receptor activation in mouse oligodendrocyte precursor cells is mediated by Na+ entry. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8569706&form=6&db=m Thrombin receptor activation by thrombin and receptor-derived peptides in platelet and CHRF-288 cell membranes: receptor-stimulated GTPase and evaluation of agonists and partial agonists. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8569708&form=6&db=m Characterization of the G protein involved in the muscarinic stimulation of adenylyl cyclase of rat olfactory bulb. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8569749&form=6&db=m Modulation of protein kinase C by adenosine: involvement of adenosine A1 receptor-pertussis toxin sensitive nucleotide binding protein system. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8573186&form=6&db=m Activation of GTP formation and high-affinity GTP hydrolysis by mastoparan in various cell membranes. G-protein activation via nucleoside diphosphate kinase, a possible general mechanism of mastoparan action. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8574691&form=6&db=m Dual regulation by mu, delta and kappa opioid receptor agonists of K+ conductance of DRG neurons and neuroblastoma X DRG neuron hybrid F11 cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8575009&form=6&db=m Myocardial Gi alpha-protein levels in patients with hypertensive cardiac hypertrophy, ischemic heart disease and cardiogenic shock. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8575536&form=6&db=m Two human alpha 2-adrenoceptor subtypes alpha 2A-C10 and alpha 2B-C2 expressed in Sf9 cells couple to transduction pathway resulting in opposite effects on cAMP production. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8576109&form=6&db=m G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8576454&form=6&db=m Eclosion hormone-stimulated cGMP levels in the central nervous system of Manduca sexta: inhibition by lipid metabolism blockers, increase in inositol(1,4,5)trisphosphate and further evidence against the involvement of nitric oxide. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8577658&form=6&db=m Beta-adrenergic regulation of cyclic AMP synthesis in cultured human syncytiotrophoblast. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8577766&form=6&db=m Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8577939&form=6&db=m Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8579369&form=6&db=m Calcium waves in fluid flow stimulated osteoblasts are G protein mediated. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8581266&form=6&db=m Involvement of G-protein alpha il subunits in activation of G-protein gated inward rectifying K+ channels (GIRK1) by human NPY1 receptors. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8584040&form=6&db=m 5-Hydroxytryptamine 5-HT1D receptors mediating inhibition of cyclic AMP accumulation in Madin-Darby canine kidney (MDCK) cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8584384&form=6&db=m Comparison of diphtheria-tetanus-two component acellular pertussis vaccines in United States and Japanese infants at 2, 4, and 6 months of age. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8584420&form=6&db=m Intracellular Cl- modulates Ca2+-induced exocytosis from rat melanotrophs through GTP-binding proteins. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8585421&form=6&db=m Effect of prostaglandin E2 on phospholipase D activity in osteoblast-like MC3T3-E1 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8587239&form=6&db=m Sequential activation of MAP kinase cascade by angiotensin II in opossum kidney cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8587393&form=6&db=m ET-1 stimulates Ca2+ currents in cardiac cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8589287&form=6&db=m Regulation of the renal Na-HCO3 cotransporter: IV. Mechanisms of the stimulatory effect of angiotensin II. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8590054&form=6&db=m ATP increases extracellular dopamine level through stimulation of P2Y purinoceptors in the rat striatum. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8590798&form=6&db=m Gi2-mediated activation of the MAP kinase cascade. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8590977&form=6&db=m Characterization of inhibition by haloperidol and chlorpromazine of a voltage-activated K+ current in rat phaeochromocytoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8590978&form=6&db=m Potent agonist action of 2-thioether derivatives of adenine nucleotides at adenylyl cyclase-linked P2Y-purinoceptors. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8591983&form=6&db=m Purinergic agonist ATP is a comitogen in thyroid FRTL-5 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8592003&form=6&db=m S100 protein CP-10 stimulates myeloid cell chemotaxis without activation. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8592114&form=6&db=m Coupling of ETB endothelin receptor to mitogen-activated protein kinase stimulation and DNA synthesis in primary cultures of rat astrocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8592124&form=6&db=m Lysophosphatidic acid-induced neurite retraction in PC12 cells: neurite-protective effects of cyclic AMP signaling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8592130&form=6&db=m Enteric glia exhibit P2U receptors that increase cytosolic calcium by a phospholipase C-dependent mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8592160&form=6&db=m A subtype of kappa-opioid receptor mediates inhibition of high-affinity GTPase inherent in Gi1 in guinea pig cerebellar membranes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8592644&form=6&db=m A P2 purinoceptor activated by ADP in rat medullar neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8593468&form=6&db=m Cholera toxin accentuates the antagonism by acetylcholine of higenamine-induced positive chronotropy is isolated right atria of mice. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8593951&form=6&db=m Induction of macrophage apoptosis by Bordetella pertussis adenylate cyclase-hemolysin. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8595194&form=6&db=m G-protein mediated responses to localized serotonin application in an invertebrate photoreceptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8595929&form=6&db=m A comparison of the effects of signal transduction inhibitors on oxidative burst and degranulation in IL-I beta stimulated bovine neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8595931&form=6&db=m Regulation of superoxide anion generation in bovine alveolar macrophages by bacterial lipopolysaccharide, serum proteins, and modulators of signal transduction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8596696&form=6&db=m Endothelin-1 inhibits L-type Ca currents enhanced by isoproterenol in guinea-pig ventricular myocytes. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8596727&form=6&db=m Inhibition of the hyperpolarization-activated current (if) of rabbit SA node myocytes by niflumic acid. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8598065&form=6&db=m Expression of opioid receptors during heart ontogeny in normotensive and hypertensive rats. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8598192&form=6&db=m Phosphorylated BvgA is sufficient for transcriptional activation of virulence-regulated genes in Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8598482&form=6&db=m Metabolism and biologic effects of 5-oxoeicosanoids on human neutrophils. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8602873&form=6&db=m Involvement of the M2 muscarinic receptor in contractions of the guinea pig trachea, guinea pig esophagus, and rat fundus. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8603123&form=6&db=m alpha2-Adrenoceptor activation increases calcium channel currents in single vascular smooth muscle cells isolated from human omental resistance arteries. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8603702&form=6&db=m Involvement of pertussis toxin-sensitive GTP-binding proteins in sphingosine 1-phosphate-induced activation of phospholipase C-Ca2+ system in HL60 leukemia cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8604977&form=6&db=m alpha-1-Adrenergic receptor stimulation causes arachidonic acid release through pertussis toxin-sensitive GTP-binding protein and JNK activation in rabbit aortic smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8605873&form=6&db=m Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8606094&form=6&db=m Nitric oxide induction by pertussis toxin in mouse spleen cells via gamma interferon. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8606119&form=6&db=m The pertussis toxin liberation genes of Bordetella pertussis are transcriptionally linked to the pertussis toxin operon. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8606353&form=6&db=m Polymerase chain reaction for the detection of Bordetella pertussis in clinical nasopharyngeal aspirates. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8606361&form=6&db=m Characterization of the G protein coupling of SRIF and beta-adrenergic receptors to the maxi KCa channel in insulin-secreting cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8606620&form=6&db=m Inhibition of cyclic AMP accumulation by endothelin is pertussis toxin sensitive and calcium independent in isolated adult feline cardiac myocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8607120&form=6&db=m Thrombin receptor activating peptide (TRAP) stimulates mitogenesis, c-fos and PDGF-A gene expression in human vascular smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8609893&form=6&db=m D2, D3, and D4 dopamine receptors couple to G protein-regulated potassium channels in Xenopus oocytes. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8609900&form=6&db=m Rat brain cannabinoid receptor modulates N-type Ca2+ channels in a neuronal expression system. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8610126&form=6&db=m G protein subunits and the stimulation of phospholipase C by Gs-and Gi-coupled receptors: Lack of receptor selectivity of Galpha(16) and evidence for a synergic interaction between Gbeta gamma and the alpha subunit of a receptor activated G protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8611426&form=6&db=m Streptococcal glycoprotein-induced tumour cell growth inhibition involves the modulation of a pertussis toxin-sensitive G protein. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8612094&form=6&db=m Age-related changes in G proteins in rat aorta. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8612978&form=6&db=m A developmental role for the heterotrimeric G protein Go alpha in a migratory population of embryonic neurons. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8613765&form=6&db=m G protein-coupled receptors mediate a fast excitatory postsynaptic current in CA3 pyramidal neurons in hippocampal slices. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8613779&form=6&db=m Rise in intracellular calcium via a nongenomic effect of allopregnanolone in fetal rat hypothalamic neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8613803&form=6&db=m Metabotropic glutamate receptor modulation of voltage-gated Ca2+ channels involves multiple receptor subtypes in cortical neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8613962&form=6&db=m Myenteric ganglionic 5-hydroxytryptamine(1P) signal transmission is mediated via Go protein. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8615767&form=6&db=m Cold-induced reduction in Gi alpha proteins in brown adipose tissue. Effects on the cellular hypersensitization to noradrenaline caused by pertussis-toxin treatment. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8615821&form=6&db=m Activation of phosphatidylinositol 3-kinase by concanavalin A through dual signaling pathways, G-protein-coupled and phosphotyrosine-related, and an essential role of the G-protein-coupled signals for the lectin-induced respiratory burst in human monocytic THP-1 cells. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8615880&form=6&db=m Receptor-independent G protein activation may account for the stimulatory effects of first-generation H1-receptor antagonists in HL-60 cells, basophils, and mast cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8615903&form=6&db=m Potentiation of mitogen-activated protein kinase by ethanol in embryonic liver cells. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8616070&form=6&db=m The regulation of neutrophil phospholipase A2 by granulocyte-macrophage colony-stimulating factor and its role in priming superoxide production. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8617745&form=6&db=m G-protein regulation of outwardly rectified epithelial chloride channels incorporated into planar bilayer membranes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8617878&form=6&db=m Endothelin(B) receptor activates NHE-3 by a Ca2+-dependent pathway in OKP cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8621150&form=6&db=m Inhibitory actions of cyclic adenosine monophosphate and pertussis toxin define two distinct epidermal growth factor-regulated pathways leading to activation of mitogen-activated protein kinase in rat hepatocytes. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8621477&form=6&db=m Wortmannin-sensitive activation of p70s6k by endogenous and heterologously expressed Gi-coupled receptors. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8621543&form=6&db=m Alpha1 adrenergic receptors activate phosphatidylinositol 3-kinase in human vascular smooth muscle cells. Role in mitogenesis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8621710&form=6&db=m Inactivation of raf-1 by a protein-tyrosine phosphatase stimulated by GTP and reconstituted by Galphai/o subunits. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8621727&form=6&db=m Integrin alphavbeta3 mediates chemotactic and haptotactic motility in human melanoma cells through different signaling pathways. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8626438&form=6&db=m Specificity of coupling of muscarinic receptor isoforms to a novel chick inward-rectifying acetylcholine-sensitive K+ channel. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8626445&form=6&db=m Acidification of serotonin-containing secretory vesicles induced by a plasma membrane calcium receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8626494&form=6&db=m Inhibition of tumor necrosis factor-induced p42/p44 mitogen-activated protein kinase activation by sodium salicylate. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8626507&form=6&db=m Identification of the peptides that stimulate the phosphoinositide hydrolysis in lymphocyte cell lines from peptide libraries. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8626678&form=6&db=m The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8627081&form=6&db=m The seroepidemiology of Bordetella pertussis infections: a study of persons ages 1-65 years. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8627299&form=6&db=m delta-Opioids stimulate inositol 1,4,5-trisphosphate formation, and so mobilize Ca2+ from intracellular stores, in undifferentiated NG108-15 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8627385&form=6&db=m Neuropeptide Y depresses GABA-mediated calcium transients in developing suprachiasmatic nucleus neurons: a novel form of calcium long-term depression. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8627554&form=6&db=m Non-neuronal release of ATP and inositol 1,4,5-trisphosphate accumulation evoked by P2- and M-receptor stimulation in guinea pig ileal segments. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8631692&form=6&db=m DNA binding of the Bordetella pertussis H1 homolog alters in vitro DNA flexibility. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8632154&form=6&db=m Transduction mechanisms involved in thrombin receptor-induced nerve growth factor secretion and cell division in primary cultures of astrocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8632325&form=6&db=m Investigation of brain sites mediating cannabinoid-induced antinociception in rats: evidence supporting periaqueductal gray involvement. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8632333&form=6&db=m Estradiol increases cyclic adenosine monophosphate in rat pulmonary vascular smooth muscle cells by a nongenomic mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8632339&form=6&db=m Regulation of 5-hydroxytryptamine release from rat midbrain raphe nuclei by 5-hydroxytryptamine1D receptors: effect of tetrodotoxin, G protein inactivation and long-term antidepressant administration. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8632341&form=6&db=m Somatostatin inhibits bombesin-stimulated Gi-protein via its own receptor in rabbit colonic smooth muscle cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8632357&form=6&db=m Sustained activation of phospholipase D via adenosine A3 receptors is associated with enhancement of antigen- and Ca(2+)-ionophore-induced secretion in a rat mast cell line. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8632715&form=6&db=m Effects of endothelin on mitogen-activated protein kinase activity and protein synthesis in isolated adult feline cardiac myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8632772&form=6&db=m Dopamine D2L receptors stimulate Na+/K(+)-ATPase activity in murine LTK- cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8635230&form=6&db=m Endothelin-dependent actions in cultured AT-1 cardiac myocytes. The role of the epsilon isoform of protein kinase C. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8635240&form=6&db=m Alpha 1-adrenergic inhibition of the beta-adrenergically activated Cl- current in guinea pig ventricular myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8635672&form=6&db=m C-peptide stimulates rat renal tubular Na+, K(+)-ATPase activity in synergism with neuropeptide Y. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8635697&form=6&db=m RANTES and platelet-activating factor open Ca2+-activated K+ channels in eosinophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8636298&form=6&db=m The biological activity of the corticotropin-releasing hormone receptor-adenylate cyclase complex in human myometrium is reduced at the end of pregnancy. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8636412&form=6&db=m Activation of heat shock protein (hsp)70 and proto-oncogene expression by alpha1 adrenergic agonist in rat aorta with age. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8636414&form=6&db=m Ca2+ channel activation by platelet-derived growth factor-induced tyrosine phosphorylation and Ras guanine triphosphate-binding proteins in rat glomerular mesangial cells. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8636427&form=6&db=m Opiate-mediated inhibition of calcium signaling is decreased in dorsal root ganglion neurons from the diabetic BB/W rat. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8637000&form=6&db=m Crystal structure of the pertussis toxin-ATP complex: a molecular sensor. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8637142&form=6&db=m Prevalence and incidence of adult pertussis in an urban population. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8637397&form=6&db=m Property of receptor for vasoactive intestinal contractor (VIC) expressed in Xenopus oocytes injected with mRNA from rat intestine. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8638712&form=6&db=m Gastrin stimulation of histamine synthesis in enterochromaffin-like cells from rabbit fundic mucosa. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8638842&form=6&db=m Dexmedetomidine injection into the locus ceruleus produces antinociception. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8640350&form=6&db=m Mastoparan-induced phosphatidylcholine hydrolysis by phospholipase D activation in human astrocytoma cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8640862&form=6&db=m Native, but not genetically inactivated, pertussis toxin protects mice against experimental allergic encephalomyelitis. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8641209&form=6&db=m Effect of thyroid hormones on G proteins in synaptosomes of chick embryo. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8641211&form=6&db=m Prostaglandin E2 activates phospholipase C and elevates intracellular calcium in cultured myometrial cells: involvement of EP1 and EP3 receptor subtypes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8641448&form=6&db=m Expression and functional characterization of a melatonin-sensitive receptor in Xenopus oocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8642411&form=6&db=m Activation of delta-opioid receptors inhibits neuronal-like calcium channels and distal steps of Ca(2+)-dependent secretion in human small-cell lung carcinoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8643087&form=6&db=m Differences in agonist-independent and -dependent 5-hydroxytryptamine2C receptor-mediated cell division. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8643163&form=6&db=m Extracellular ATP augments mesangial cell growth induced by multiple growth factors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8643659&form=6&db=m Determinants of the G protein-dependent opioid modulation of neuronal calcium channels. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8645172&form=6&db=m Muscarinic m1 receptor-stimulated adenylate cyclase activity in Chinese hamster ovary cells is mediated by Gs alpha and is not a consequence of phosphoinositidase C activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8645177&form=6&db=m The differential regulation of cyclic AMP by sphingomyelin-derived lipids and the modulation of sphingolipid-stimulated extracellular signal regulated kinase-2 in airway smooth muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8645326&form=6&db=m G-protein modulation of neuronal class E (alpha 1E) calcium channel expressed in GH3 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8646346&form=6&db=m Acetylcholine-induced calcium signaling associated with muscarinic receptor activation in cultured myenteric neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8646408&form=6&db=m Differences in the operational characteristics of the human recombinant somatostatin receptor types, sst1 and sst2, in mouse fibroblast (Ltk-) cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647085&form=6&db=m The metabolism of sphingo(glyco)lipids is correlated with the differentiation-dependent autophagic pathway in HT-29 cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647116&form=6&db=m Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor. Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647187&form=6&db=m Dissection of lymphocyte function-associated antigen 1-dependent adhesion and signal transduction in human natural killer cells shown by the use of cholera or pertussis toxin. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647240&form=6&db=m Stimulation of mitogen activated protein kinase by LDL and oxLDL in human U-937 macrophage-like cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647917&form=6&db=m Thrombin induces proliferation of osteoblast-like cells through phosphatidylcholine hydrolysis. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647918&form=6&db=m Neutrophil thrombospondin receptors are linked to GTP-binding proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647953&form=6&db=m Mechanism of cytokine-induced modulation of beta-adrenoceptor responsiveness in airway smooth muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8648142&form=6&db=m Inhibition by CTLA4Ig of experimental allergic encephalomyelitis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8649355&form=6&db=m A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8650255&form=6&db=m PGF2alpha-induced signaling events in glomerular mesangial cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8650986&form=6&db=m -Myocardial protection by preconditioning. Experimental and clinical significance-. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8652528&form=6&db=m The role of G protein methylation in the function of a geranylgeranylated beta gamma isoform. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8653087&form=6&db=m Effects of synthesized elastin peptides on human leukocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8655466&form=6&db=m Hypoxic preconditioning in isolated rat hearts: non-involvement of activation of adenosine A1 receptor, Gi protein, and ATP-sensitive K+ channel. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8656040&form=6&db=m Polymorphonuclear leukocyte opsonic receptor expression after hypoxia/reoxygenation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8656645&form=6&db=m Endothelin-1 partially inhibits ATP-sensitive K+ current in guinea pig ventricular cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8660299&form=6&db=m Signalling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8662272&form=6&db=m Adrenaline-, not somatostatin-induced hyperpolarization is accompanied by a sustained inhibition of insulin secretion in INS-1 cells. Activation of sulphonylurea K+ATP channels is not involved. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8662290&form=6&db=m Different endothelin receptor subtypes are involved in phospholipid signalling in the proximal tubule of rat kidney. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8662655&form=6&db=m Interactions of phosducin with defined G protein beta gamma-subunits. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8662760&form=6&db=m Activation of the mitogen-activated protein kinase pathway by fMet-leu-Phe in the absence of Lyn and tyrosine phosphorylation of SHC in transfected cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8662799&form=6&db=m Inhibition of NAD+ glycohydrolase and ADP-ribosyl cyclase activities of leukocyte cell surface antigen CD38 by gangliosides. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8662841&form=6&db=m Pertussis toxin-sensitive activation of phospholipase C by the C5a and fMet-Leu-Phe receptors. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8662912&form=6&db=m Identification of an essential signaling cascade for mitogen-activated protein kinase activation by angiotensin II in cultured rat vascular smooth muscle cells. Possible requirement of Gq-mediated p21ras activation coupled to a Ca2+/calmodulin-sensitive tyrosine kinase. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8663226&form=6&db=m Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8663391&form=6&db=m Identification and molecular characterization of a m5 muscarinic receptor in A2058 human melanoma cells. Coupling to inhibition of adenylyl cyclase and stimulation of phospholipase A2. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8663428&form=6&db=m Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8663432&form=6&db=m 5-Oxo-eicosanoids and hematopoietic cytokines cooperate in stimulating neutrophil function and the mitogen-activated protein kinase pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8664168&form=6&db=m Cholera toxin directly stimulates pregnenolone generation with increasing Ca2+ efflux in bovine adrenocortical mitochondria. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8664283&form=6&db=m Oxidized low-density lipoprotein stimulates protein kinase C (PKC) and induces expression of PKC-isotypes via prostaglandin-H-synthase in P388D1 macrophage-like cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8666011&form=6&db=m Regulation of Na(+)-pump activity by dopamine in rat tail arteries. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8666909&form=6&db=m Mechanisms of platelet-activating factor-induced lipid body formation: requisite roles for 5-lipoxygenase and de novo protein synthesis in the compartmentalization of neutrophil lipids. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8667029&form=6&db=m Adenosine release and uptake in cerebellar granule neurons both occur via an equilibrative nucleoside carrier that is modulated by G proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8670070&form=6&db=m P2-purigenic receptors regulate phospholipase C and adenylate cyclase activities in immortalized Schwann cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8670085&form=6&db=m Thapsigargin activates univalent- and bivalent-cation entry in human neutrophils by a SK&F I3 96365- and Gd3+-sensitive pathway and is a partial secretagogue: involvement of pertussis-toxin-sensitive G-proteins and protein phosphatases 1/2A and 2B in the signal-transduction pathway. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8670111&form=6&db=m Analysis of inverse agonism at the delta opioid receptor after expression in Rat 1 fibroblasts. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8670119&form=6&db=m High-glucose incubation of human umbilical-vein endothelial cells does not alter expression and function either of G-protein alpha-subunits or of endothelial NO synthase. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8670881&form=6&db=m Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8674763&form=6&db=m Effect of pertussis toxin and PGE2 on the functioning of the IL-2 promoter in interleukin-1 treated EL4.NOB-1 thymoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8678289&form=6&db=m Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8680721&form=6&db=m Coupling of an endogenous 5-HT1B-like receptor to increases in intracellular calcium through a pertussis toxin-sensitive mechanism in CHO-K1 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8680724&form=6&db=m A novel P2-purinoceptor expressed by a subpopulation of astrocytes from the dorsal spinal cord of the rat. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8683460&form=6&db=m Selective inhibition of high voltage-activated L-type and Q-type Ca2+ currents by serotonin in rat melanotrophs. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8683464&form=6&db=m Enhancement of delayed rectifier K+ current by P2-purinoceptor stimulation in guinea-pig atrial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8683465&form=6&db=m Activation of the muscarinic K+ channel by P2-purinoceptors via pertussis toxin-sensitive G proteins in guinea-pig atrial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8684611&form=6&db=m Somatostatin receptor subtypes SSTR2 and SSTR5 couple negatively to an L-type Ca2+ current in the pituitary cell line AtT-20. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8685083&form=6&db=m Stable guanosine 5'-triphosphate-analogues inhibit specific (+)-[3H]isradipine binding in rat hearts by a Ca(2+)-lowering, G protein-independent mechanism. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8689388&form=6&db=m Mitoxantrone induces nonimmunological histamine release from rat mast cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8689391&form=6&db=m Reconstitution of chemokine-induced actin polymerization in undifferentiated human leukemia cells (HL-60) by heterologous expression of interleukin-8 receptors. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8689670&form=6&db=m Pancreastatin inhibits insulin secretion in RINm5F cells through obstruction of G-protein mediated, calcium-directed exocytosis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8690152&form=6&db=m Lithium stimulation of rat pancreatic beta-cell replication is mediated through pertussis toxin-sensitive GTP-binding proteins and occurs independently of Ca2+ influx, cAMP, or protein kinase C activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8690235&form=6&db=m Thromboxane A2 receptor-mediated signal transduction in rabbit aortic smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8690252&form=6&db=m Multiplicative interaction between intrathecally and intracerebroventricularly administered morphine for antinociception in the mouse: effects of spinally and supraspinally injected 3-isobutyl-1-methylxanthine, cholera toxin, and pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8690785&form=6&db=m Proadrenomedullin NH2-terminal 20 peptide inhibits the voltage-gated Ca2+ channel current through a pertussis toxin-sensitive G protein in rat pheochromocytoma-derived PC 12 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8691134&form=6&db=m Platelet-activating factor exerts mitogenic activity and stimulates expression of interleukin 6 and interleukin 8 in human lung fibroblasts via binding to its functional receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8691524&form=6&db=m Extracellular matrix proteins are potent agonists of human smooth muscle cell migration. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8692916&form=6&db=m Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8694386&form=6&db=m Stimulation of alpha 2 adrenoceptors dilates the rat middle cerebral artery. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8694860&form=6&db=m Lipocortin 1 and the control of cPLA2 activity in A549 cells. Glucocorticoids block EGF stimulation of cPLA2 phosphorylation. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8694903&form=6&db=m G protein-mediated activation of a nonspecific cation current in cultured rat retinal pigment epithelial cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8698438&form=6&db=m Parathyroid hormone-related protein inhibits indothelin-1 production. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8698840&form=6&db=m Pertussis toxin-sensitive G-proteins inhibit fibroblast growth factor-induced signaling in pancreatic acini. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8699119&form=6&db=m Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8699243&form=6&db=m Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8700109&form=6&db=m Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8700117&form=6&db=m mu-Opioid receptors inhibit dopamine-stimulated activity of type V adenylyl cyclase but enhance dopamine-stimulated activity of type VII adenylyl cyclase. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8700143&form=6&db=m Structural requirements for G(o) activation by receptor-derived peptides: activation and modulation domains of the alpha 2-adrenergic receptor i3c region. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8700150&form=6&db=m Alpha 2-adrenergic receptors activate phospholipase C in renal epithelial cells. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8700529&form=6&db=m The brain specific Ras exchange factor CDC25 Mm: modulation of its activity through Gi-protein-mediated signals. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8700891&form=6&db=m Inhibition of G-protein betagamma-subunit functions by phosducin-like protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8702483&form=6&db=m Receptor up-regulation, internalization, and interconverting receptor states. Critical components of a quantitative description of N-formyl peptide-receptor dynamics in the neutrophil. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8702617&form=6&db=m Cytoplasmic domain of natriuretic peptide receptor-C inhibits adenylyl cyclase. Involvement of a pertussis toxin-sensitive G protein. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8702909&form=6&db=m Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8702936&form=6&db=m Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8702939&form=6&db=m The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8703004&form=6&db=m Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular function. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8704827&form=6&db=m G proteins in carotid body chemoreception. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8706858&form=6&db=m Identification of the functional region on the superantigen Yersinia pseudotuberculosis-derived mitogen responsible for induction of lymphocyte proliferation by using synthetic peptides. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8707356&form=6&db=m Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of Mac-1(CD11b/CD18) and urokinase receptor (CD87). ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8707867&form=6&db=m Adenosine-mediated inhibition of casein production by mouse mammary glands in culture. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8709006&form=6&db=m [Receptor-mediated signal transduction] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8710864&form=6&db=m Dual signal transduction through delta opioid receptors in a transfected human T-cell line. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8712527&form=6&db=m Effect of pertussis toxin and B-oligomer on platelet-activating factor-induced generation of inositol phosphates in porcine alveolar macrophages. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8712682&form=6&db=m Modulation of calcium signalling and proliferation in monoblastoid U-937 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8713457&form=6&db=m DCG-IV selectively attenuates rapidly triggered NMDA-induced neurotoxicity in cortical neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8713997&form=6&db=m Parturition: activation of stimulatory pathways or loss of uterine quiescence? unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8713998&form=6&db=m Oxytocin signalling in human myometrium. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8713999&form=6&db=m Mechanisms regulating oxytocin receptor coupling to phospholipase C in rat and human myometrium. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8717151&form=6&db=m Stimulation of histamine H2- (and H1)-receptors activates Ca2+ influx in all-trans-retinoic acid-differentiated HL-60 cells independently of phospholipase C or adenylyl cyclase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8719514&form=6&db=m Mucosal and systemic immunogenicity of a recombinant, non-ADP-ribosylating pertussis toxin: effects of formaldehyde treatment. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8719704&form=6&db=m Long-term neuroleptic treatments counteract dopamine D2 agonist inhibition of adenylate cyclase but do not affect pertussis toxin ADP-ribosylation in the rat brain. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8720484&form=6&db=m Selective enhancement of antagonist ligand binding at muscarinic M2 receptors by heparin due to receptor uncoupling. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8721674&form=6&db=m Endothelin-induced cytoskeletal actin re-organization in cultured astrocytes: inhibition by C3 ADP-ribosyltransferase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8723843&form=6&db=m ATP-evoked inositol phosphates formation through activation of P2U purinergic receptors in cultured astrocytes: regulation by PKC subtypes alpha, delta, and theta. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8724987&form=6&db=m Tachykinins cause inward current through NK1 receptors in bullfrog sensory neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8725176&form=6&db=m Differential regulation of receptor-stimulated cyclic adenosine monophosphate production by polyvalent cations in MC3T3-E1 osteoblasts. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8726354&form=6&db=m Ligation of the alpha 2-macroglobulin signaling receptor on macrophages induces synthesis of platelet activating factor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8726398&form=6&db=m Inositol 1-,4-,5-trisphosphate-dependent Ca2+ signaling by the recombinant human PTH/PTHrP receptor stably expressed in a human kidney cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8726701&form=6&db=m Angiotensin II stimulates protein phosphatase 2A activity in cultured neuronal cells via type 2 receptors in a pertussis toxin sensitive fashion. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8730756&form=6&db=m Evidence for a discrete UTP receptor in cardiac endothelial cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8731016&form=6&db=m In vitro and in vivo induction of nitric oxide by murine macrophages stimulated with Bordetella pertussis. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8732275&form=6&db=m Operational characteristics of somatostatin receptors mediating inhibitory actions on rat locus coeruleus neurones. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8733729&form=6&db=m Melatonin receptors activate heteromeric G-protein coupled Kir3 channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8734330&form=6&db=m [Suppression of platelet activating factor effects (PAF) on the retina by G-proteins inhibitors] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8734982&form=6&db=m Calcium handling and purinoceptor subtypes involved in ATP-induced contraction in rat small mesenteric arteries. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8735545&form=6&db=m The effect of formaldehyde, hydrogen peroxide and genetic detoxification of pertussis toxin on epitope recognition by murine monoclonal antibodies. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8735590&form=6&db=m An adenosine derivative cooperates with TSH and Graves' IgG to induce Ca2+ mobilization in single human thyroid cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8735605&form=6&db=m Different sites of action of arachidonic acid on steroidogenesis in rat Leydig cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8735615&form=6&db=m The effect of nociceptin on Ca2+ channel current and intracellular Ca2+ in the SH-SY5Y human neuroblastoma cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8735960&form=6&db=m Release of serotonin from RBL-2H3 cells by the Escherichia coli peptide toxin STb. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8736436&form=6&db=m PACAP and VIP stimulate Ca2+ oscillations in rat gonadotrophs through the PACAP/VIP type 1 receptor (PVR1) linked to a pertussis toxin-insensitive G-protein and the activation of phospholipase C-beta. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8736707&form=6&db=m G proteins in adipocytes and preadipocytes: characterization, subcellular distribution, and potential roles for Gi2 and/or Gi3 in the control of cell proliferation. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8738163&form=6&db=m The endogenous benzodiazepine receptor ligand ODN increases cytosolic calcium in cultured rat astrocytes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8739246&form=6&db=m Beta-adrenoceptor mediated signal transduction in congestive heart failure in cardiomyopathic (UM-X7.1) hamsters. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8741589&form=6&db=m Cell-density-dependent expression of the beta-adrenergic response by epidermal growth factor (EGF) in primary cultures of adult rat hepatocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8742493&form=6&db=m G-protein-coupled receptors in HL-60 human leukemia cells. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8744555&form=6&db=m Pertussis toxin enhanced IgG1 and IgE responses to primary tetanus immunization are mediated by interleukin-4 and persist during secondary responses to tetanus alone. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8745058&form=6&db=m Effect of phenylephrine and prazosin on the somatostatinergic system in the rat frontoparietal cortex. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8745294&form=6&db=m Mechanism of action of ATP on canine pulmonary vagal C fibre nerve terminals. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8747522&form=6&db=m Regulation of plasminogen activator inhibitor activity by plasmin in endothelial cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8748073&form=6&db=m Morphine stimulates phagocytosis of Mycobacterium tuberculosis by human microglial cells: involvement of a G protein-coupled opiate receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8748122&form=6&db=m Withdrawal of somatostatin augments L-type Ca2+ current in primary cultured rat somatotrophs. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8748207&form=6&db=m Neuropeptide Y and hypertension. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8749026&form=6&db=m Possible participation of histamine H3 receptors in the modulation of noradrenaline release from rat spinal cord slices. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8749028&form=6&db=m Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8751074&form=6&db=m Differential calcium signalling by m2 and m3 muscarinic acetylcholine receptors in a single cell type. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8751157&form=6&db=m Enhanced expression of GTP-binding proteins in differentiated U937 monocytic cells: possible involvement of tyrosine kinase and protein kinase C. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8751953&form=6&db=m Phospholipid metabolism induced by Clostridium perfringens alpha-toxin elicits a hot-cold type of hemolysis in rabbit erythrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8752121&form=6&db=m Receptor-mediated activation of G proteins is increased in postmortem brains of bipolar affective disorder subjects. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8752140&form=6&db=m Functional coupling of the delta-, mu-, and kappa-opioid receptors to mitogen-activated protein kinase and arachidonate release in Chinese hamster ovary cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8752494&form=6&db=m [Involvement of G proteins between receptors and KCa channels in the regulation of airway tone by the autonomic nervous system] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8752584&form=6&db=m Activation of nucleotide receptors inhibits high-threshold calcium currents in NG108-15 neuronal hybrid cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8755611&form=6&db=m Cytosolic Na+ controls and epithelial Na+ channel via the Go guanine nucleotide-binding regulatory protein. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8757339&form=6&db=m Beta-chemokine TCA3 binds to and activates rat vascular smooth muscle cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8759757&form=6&db=m C3a and C5a are chemotaxins for human mast cells and act through distinct receptors via a pertussis toxin-sensitive signal transduction pathway. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8760037&form=6&db=m Regulation of HSP70 by PTH: a model of gene regulation not mediated by changes in cAMP levels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8760043&form=6&db=m Angiotensin-converting enzyme inhibitors regulate the Na(+)-K+ pump via effects on angiotensin metabolism. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8760055&form=6&db=m Cellular mechanisms underlying adenosine actions on cholinergic transmission in enteric neurons. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8760083&form=6&db=m Involvement of G proteins in the effect of carbachol and cholecystokinin in rat pancreatic islets. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8760188&form=6&db=m Vanadate causes synthesis of endothelium-derived NO via pertussis toxin-sensitive G protein in pigs. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8760201&form=6&db=m Subcellular mechanisms of angiotensin II and arginine vasopressin activation of area postrema neurons. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8762108&form=6&db=m Adenosine inhibitory effect on enhanced growth of aortic smooth muscle cells from streptozotocin-induced diabetic rats. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8763164&form=6&db=m Investigation of presumptive mobilization pathways for calcium in the steroidogenic action of big prothoracicotropic hormone. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8764317&form=6&db=m PGE2 reverses AVP inhibition of HCO3- absorption in rat MTAL by activation of protein kinase C. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8764370&form=6&db=m Dopamine D2L receptor couples to G alpha i2 and G alpha i3 but not G alpha i1, leading to the inhibition of adenylate cyclase in transfected cell lines. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8764650&form=6&db=m Selective G-protein regulation of neuronal calcium channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8764666&form=6&db=m Protein kinase and G-protein regulation of Ca2+ currents in Hermissenda photoreceptors by 5-HT and GABA. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8765040&form=6&db=m Human eotaxin represents a potent activator of the respiratory burst of human eosinophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8765984&form=6&db=m Melatonin receptors in the chicken kidney are up-regulated by pinealectomy and linked to adenylate cyclase. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8766003&form=6&db=m Modulation of Ca2+ channels by intracellular Mg2+ ions and GTP in frog ventricular myocytes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8766700&form=6&db=m Expression and secretion of beta-glucuronidase and Pertussis toxin S1 by Streptomyces lividans. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8768693&form=6&db=m Angiotensin II-mediated activation of L-type calcium channels involves phosphatidylinositol hydrolysis-independent activation of protein kinase C in rat portal vein myocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8768791&form=6&db=m Acellular pertussis vaccine composed of genetically inactivated pertussis toxin. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8769378&form=6&db=m Effector coupling of somatostatin receptor subtypes on human endocrine tumors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8769988&form=6&db=m Signal transduction and glial cell modulation of cultured brain microvessel endothelial cell tight junctions. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8769995&form=6&db=m Dual regulation of PLA2 and PGI2 production by G proteins in bovine aortic endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8770101&form=6&db=m Angiotensin II type 1 receptor-mediated activation of Ras in cultured rat vascular smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8770114&form=6&db=m Beta-adrenergic modulation of Na-K pump activity in young and adult canine cardiac Purkinje fibers. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8770167&form=6&db=m Albumin endocytosis is regulated by heterotrimeric GTP-binding protein G alpha i-3 in opossum kidney cells. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8770511&form=6&db=m Long-term human serum antibody responses after immunization with whole-cell pertussis vaccine in France. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,1,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8771531&form=6&db=m Fixation traps formyl peptide receptors in high and low affinity forms that can be regulated by GTP[S] in the absence of ligand. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8774153&form=6&db=m Stearate inhibition of breast cancer cell proliferation. A mechanism involving epidermal growth factor receptor and G-proteins. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8777142&form=6&db=m Involvement of pertussis toxin-sensitive and -insensitive G proteins in alpha-thrombin signalling on cultured human vascular smooth muscle cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8779973&form=6&db=m ATP-induced rise in apamin-sensitive Ca(2+)-dependent K+ conductance in adult rat hepatocytes. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8780200&form=6&db=m Phospholipase D is activated by G protein and not by calcium ions in vascular smooth muscle. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8781552&form=6&db=m Involvement of the beta gamma subunits of inhibitory GTP-binding protein in chemoattractant receptor-mediated potentiation of cyclic AMP formation in guinea pig neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8781557&form=6&db=m Prostaglandins inhibit pancreatic beta-cell replication and long-term insulin secretion by pertussis toxin-insensitive mechanisms but do not mediate the actions of interleukin-1 beta. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8781562&form=6&db=m Regulation of phosphorylation of Gi2 alpha protein controls the secretory response to isoproterenol in rat parotid tissues. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8781564&form=6&db=m Activation of mesangial cells with TNF-alpha stimulates M-CSF gene expression and monocyte proliferation: evidence for involvement of protein kinase C and protein tyrosine kinase. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8782102&form=6&db=m Hypotonic stimulation induced Ca2+ release from IP3-sensitive internal stores in a green monkey kidney cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8782112&form=6&db=m Vasoactive intestinal polypeptide modulation of nicotinic ACh receptor channels in rat intracardiac neurones. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8783273&form=6&db=m A somatostatin receptor inhibits noradrenaline release from chick sympathetic neurons through pertussis toxin-sensitive mechanisms: comparison with the action of alpha 2-adrenoceptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8784077&form=6&db=m Coupling of gonadotropin-releasing hormone receptor to Gi protein in human reproductive tract tumors. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8785949&form=6&db=m Validation of the toxin-binding inhibition (ToBI) test for the estimation of the potency of the tetanus toxoïd component in vaccines. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8786295&form=6&db=m Effects of nicotine on the immune response. II. Chronic nicotine treatment induces T cell anergy. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8786321&form=6&db=m TNF-alpha stimulates monocyte adhesion to glomerular mesangial cells. The role of intercellular adhesion molecule-1 gene expression and protein kinases. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8786435&form=6&db=m Muscarinic (m2/m4) receptors reduce N- and P-type Ca2+ currents in rat neostriatal cholinergic interneurons through a fast, membrane-delimited, G-protein pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8786539&form=6&db=m Development of a selective agonist at the somatostatin receptor subtype sstr1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8786562&form=6&db=m Modification of serotonin responses in rat dorsolateral septal nucleus neurons by acute and chronic cocaine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8786573&form=6&db=m Localization and characterization of the subtypes(s) of muscarinic receptor involved in prostacyclin synthesis in rabbit heart. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8787364&form=6&db=m Randomized controlled trial of acellular diphtheria, pertussis and tetanus vaccines in southern Ghana. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8788451&form=6&db=m Pretreatment with pertussis toxin blocks morphine- but not beta-endorphin-induced antinociception in the mouse. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8788935&form=6&db=m Activation of muscarinic K+ current in guinea-pig atrial myocytes by sphingosine-1-phosphate. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8789387&form=6&db=m delta- and mu-opioid receptor mobilization of intracellular calcium in SH-SY5Y human neuroblastoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8789390&form=6&db=m Oestradiol-induced relaxation of rabbit basilar artery by inhibition of voltage-dependent Ca channels through GTP-binding protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8790577&form=6&db=m Upregulation of Na(+)-dependent alanine transport in vascular endothelial cells by serum: role of intracellular Ca2+. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8791006&form=6&db=m A tyrosine kinase regulates alpha-adrenoceptor-stimulated contraction and phospholipase D activation in the rat aorta. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8791008&form=6&db=m Chronic exposure of NG 108-15 cells to inhibitory acting drugs reduces stimulatory prostaglandin E1 receptor number. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8793911&form=6&db=m 5-HT1A receptor-mediated inhibition of acetylcholine release from guinea pig myenteric plexus: potential mechanisms. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8794831&form=6&db=m Thromboxane A2 mediates the stimulation of inositol 1,4,5-trisphosphate production and intracellular calcium mobilization by bradykinin in neonatal rat ventricular cardiomyocytes. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8794890&form=6&db=m Angiotensin II type 1 receptor signals through Raf-1 by a protein kinase C-dependent, Ras-independent mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8794899&form=6&db=m The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8794903&form=6&db=m Direct evidence for functional coupling of the vasoactive intestinal peptide receptor to Gi3 in native lung membranes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8795068&form=6&db=m Pertussis toxin sensitive G-proteins are not involved in the mitogenic signaling pathway of insulin-like growth factor-I in normal rat kidney epithelial (NRKE) cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8795079&form=6&db=m Bombesin activation of phospholipase C beta 1 in rat acinar pancreatic cells involves the pertussis toxin-sensitive G alpha i3 protein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8798276&form=6&db=m Effects of pertussis toxin treatment of rats on estradiol-induced adenohypophyseal growth reaction and on adrenergic lipolysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8798377&form=6&db=m G-protein beta gamma subunits mediate specific phosphorylation of the protein-tyrosine phosphatase SH-PTP1 induced by lysophosphatidic acid. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8798386&form=6&db=m Activation of a mitogen-activated protein kinase (ERK2) by the 5-hydroxytryptamine1A receptor is sensitive not only to inhibitors of phosphatidylinositol 3-kinase, but to an inhibitor of phosphatidylcholine hydrolysis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8799575&form=6&db=m Phospholipase C isoforms in vascular smooth muscle and their regulation by G-proteins. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8805659&form=6&db=m I-309/T cell activation gene-3 chemokine protects murine T cell lymphomas against dexamethasone-induced apoptosis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8805672&form=6&db=m Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8806086&form=6&db=m Progesterone triggers rapid transmembrane calcium influx and/or calcium mobilization from endoplasmic reticulum, via a pertussis-insensitive G-protein in granulosa cells in relation to luteinization process. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8806702&form=6&db=m G(o) protein does not regulate ATP-stimulated [Ca2+]i elevation or noradrenaline release in PC12 cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8806749&form=6&db=m Characterization of alpha 2-macroglobulin binding to human trabecular meshwork cells: presence of the alpha 2-macroglobulin signaling receptor. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8806921&form=6&db=m Modulation of respiratory rhythm in vitro: role of Gi/o protein-mediated mechanisms. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8808644&form=6&db=m Substance P activates the release of histamine from human skin mast cells through a pertussis toxin-sensitive and protein kinase C-dependent mechanism. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8809733&form=6&db=m Lack of endogenous adenosine receptor activation explains the insensitivity of neonatal rat Leydig cells to treatment with pertussis toxin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8809827&form=6&db=m Complement 5a controls motility of murine microglial cells in vitro via activation of an inhibitory G-protein and the rearrangement of the actin cytoskeleton. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8813557&form=6&db=m Regulation of Na+,K(+)-ATPase activity by dopamine in cultured rat aortic smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8813602&form=6&db=m Adenosine activates the K+ channel and enhances cytosolic Ca2+ release via a P2Y purinoceptor in hippocampal neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8814246&form=6&db=m The interleukin-8 receptor B and CXC chemokines can mediate transendothelial migration of human skin homing T cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8815083&form=6&db=m Immunomagnetic separation and solid-phase detection of Bordetella pertussis. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8815088&form=6&db=m Validation of nested Bordetella PCR in pertussis vaccine trial. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8815880&form=6&db=m Metabotropic glutamate receptors activate G-protein-coupled inwardly rectifying potassium channels in Xenopus oocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8816421&form=6&db=m Sequential morphologic events during apoptosis of human neutrophils. Modulation by lipoxygenase-derived eicosanoids. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8817823&form=6&db=m Adverse reactions and antibody response to four doses of acellular or whole cell pertussis vaccine combined with diphtheria and tetanus toxoids in the first 19 months of life. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8818543&form=6&db=m N-formyl-methionyl-leucyl-phenylalanine induces and modulates IL-1 and IL-6 in human PBMC. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8819149&form=6&db=m Modulation by protein kinase C of the enhanced responsiveness to tachykinins in ovalbumin-sensitized guinea pig alveolar macrophages. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8819496&form=6&db=m Expression and modulation of 5-hydroxytryptamine1A receptors in P11 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8819527&form=6&db=m Spinal morphine/clonidine antinociceptive synergism: involvement of G proteins and N-type voltage-dependent calcium channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8821710&form=6&db=m Effects of pertussis toxin on signal transductions via P2-purinergic receptors in A-431 human epidermoidal carcinoma cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8821810&form=6&db=m Modulation of cyclic AMP accumulation in glial cells by exogenous phospholipase C. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8824306&form=6&db=m Modulation of voltage-gated calcium channels by orphanin FQ in freshly dissociated hippocampal neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8824967&form=6&db=m Effect of inactivated poliovirus vaccine on the antibody response to Bordetella pertussis antigens when combined with diphtheria-pertussis-tetanus vaccine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8825091&form=6&db=m Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8825093&form=6&db=m Identification of Salmonella typhi promoters activated by invasion of eukaryotic cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8829961&form=6&db=m Abnormalities of the myocytes in ischaemic cardiomyopathy. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8830788&form=6&db=m Transient inhibition of capacitative calcium entry in human neutrophils by a monoclonal antibody directed against a 19-kDa antigen. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8831937&form=6&db=m Na+/H+ exchange in hypertension and in diabetes mellitus--facts and hypotheses. causal interaction,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8832055&form=6&db=m Mechanism of inhibition of calcium channels in rat nucleus tractus solitarius by neurotransmitters. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8832213&form=6&db=m The excitatory effect of cholecystokinin on rat neostriatal neurons: ionic and molecular mechanisms. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8833196&form=6&db=m The inhibition of motility that results from contact between two oligodendrocytes in vitro can be blocked by pertussis toxin. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8833736&form=6&db=m Mechanism of stress-induced attenuation of the testicular response to gonadotropin: possible involvement of testicular opioids, a pertussis toxin-sensitive G-protein, and phosphodiesterase. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8834806&form=6&db=m Localization of G alpha 0 to growth cones in PC12 cells: role of G alpha 0 association with receptors and G beta gamma. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8838460&form=6&db=m Sensitivity of histamine H3 receptor agonist-stimulated [35S]GTP gamma[S] binding to pertussis toxin. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8840123&form=6&db=m Effect of pertussis toxin on morphine, diphenhydramine, baclofen, clomipramine and physostigmine antinociception. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8840354&form=6&db=m G-protein level quantification in platelets and leukocytes from patients with panic disorder. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8842005&form=6&db=m Modulation of excitatory synaptic transmission by low concentrations of glutamate in cultured rat hippocampal neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8842386&form=6&db=m Brain pertussis toxin-sensitive G proteins are involved in the flavoxate hydrochloride-induced suppression of the micturition reflex in rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8842396&form=6&db=m Prolonged pertussis toxin treatment affects morphine's action on tuberoinfundibular dopaminergic neuron activity and on prolactin secretion. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8842420&form=6&db=m Characterization of the PGE2 receptor subtype in bovine chondrocytes in culture. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8842427&form=6&db=m P2-purinoceptor-mediated formation of inositol phosphates and intracellular Ca2+ transients in human coronary artery smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8842435&form=6&db=m Interleukin-1 beta stimulation of 45Ca2+ release from rat striatal slices. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8843493&form=6&db=m Metabotropic glutamate receptor subtype 1A activates adenylate cyclase when expressed in baby hamster kidney cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8843633&form=6&db=m The use of Haemophilus influenzae type b-tetanus toxoid conjugate vaccine mixed with diphtheria-tetanus-pertussis vaccine in Gambian infants. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8843635&form=6&db=m Responses to primary and a booster dose of acellular, component, and whole-cell pertussis vaccines initiated at 2 months of age. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8843700&form=6&db=m Mechanisms of recovery from mechanical injury of cultured rat hepatocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8843720&form=6&db=m Modulation of phospholipase C pathway and level of Gq alpha/G11 alpha in rat myometrium during gestation. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8843784&form=6&db=m ETA and ETB receptors cooperate in DNA synthesis via opposing regulations of cAMP in human lung cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8845740&form=6&db=m Regulation of intracellular [Ca2+] and GABA release by presynaptic GABAB receptors in rat cerebrocortical synaptosomes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8846514&form=6&db=m Role of intracellular signalling pathways in hydrogen peroxide-induced injury to rat glomerular mesangial cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8847268&form=6&db=m Mechanism of action of endothelin-1 in the canine pulmonary circulation. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8847638&form=6&db=m A-type potassium current modulated by A1 adenosine receptor in frog melanotrophs. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8847859&form=6&db=m Muscarinic receptor heterogeneity in neonatal rat ventricular myocytes in culture. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8847999&form=6&db=m Development and use of a receptor antibody to characterize the interaction between somatostatin receptor subtype 1 and G proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8848103&form=6&db=m G protein-coupled inward rectifier modulated by dopamine agonists in cultured substantia nigra neurons. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8851176&form=6&db=m Integrin alpha v beta 3 and phospholipase C regulate prostacyclin formation of endothelial cells caused by ancrod-generated fibrin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8853423&form=6&db=m Heterogeneity of P2u- and P2y-purinergic receptor regulation of phospholipases in MDCK cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8853708&form=6&db=m Inhibition of calcium spikes by gamma-amino-butyric acid in the neurons of Lymnaea stagnalis L. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8854008&form=6&db=m Reasons for instability of bacterial vaccines. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8854009&form=6&db=m The reaction of bacterial toxins with formaldehyde and its use for antigen stabilization. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8855287&form=6&db=m Differential regulation of beta 1 and beta 2 integrin avidity by chemoattractants in eosinophils. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8856473&form=6&db=m Characterization of signaling pathways of P2Y and P2U purinoceptors in bovine pulmonary artery endothelial cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8858925&form=6&db=m Exposure of astrocytes to thrombin reduces levels of the metabotropic glutamate receptor mGluR5. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8858930&form=6&db=m Guanine nucleotide regulatory proteins, Gq and Gi1/2, mediate platelet-activating factor-stimulated phosphoinositide metabolism in immortalized hippocampal cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8858973&form=6&db=m Pretreatment with pertussis toxin differentially modulates morphine- and beta-endorphin-induced antinociception in the mouse. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8860950&form=6&db=m Cell-density-dependent expression of the alpha(2)-adrenergic response by epidermal growth factor (EGF) in primary cultures of adult rat hepatocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8861392&form=6&db=m Transfer of a pertussis toxin expression locus to isogenic bvg-positive and bvg-negative strains of Bordetella bronchiseptica using an in vivo technique. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8861537&form=6&db=m Modulation of islet G-proteins, alpha-glucosidehydrolase inhibition and insulin release stimulated by various secretagogues. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8861541&form=6&db=m Phospholipase C activation in rat pituitary adenoma (GH) cells. causal interaction,ongoing research,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8861610&form=6&db=m Heterotrimeric G protein activation rapidly inhibits outgrowth of optic axons from adult and embryonic mouse, and goldfish retinal explants. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8862147&form=6&db=m Potentiation of acetylcholine-induced responses in freshly isolated rabbit aortic endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8863841&form=6&db=m Voltage-dependent inhibition of Ca2+ channels in GH3 cells by cloned mu- and delta-opioid receptors. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8863843&form=6&db=m Sensitization of endogenous and recombinant adenylate cyclase by activation of D2 dopamine receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8863847&form=6&db=m Mechanism of extracellular ATP-induced proliferation of vascular smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8863852&form=6&db=m m3 Muscarinic receptor-induced and Gi-mediated heterologous potentiation of phospholipase C stimulation: role of phosphoinositide synthesis. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8864565&form=6&db=m Thromboxane A2 agonist modulation of excitatory synaptic transmission in the rat hippocampal slice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8864691&form=6&db=m Pretreatment with pertussis toxin spinally, but not supraspinally, blocks the cold water swimming-induced antinociception in the mouse. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8865066&form=6&db=m The mechanism of calcium channel facilitation in bovine chromaffin cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8865089&form=6&db=m Head-activator induced mitosis of NH15-CA2 cells requires calcium influx and hyperpolarization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8866479&form=6&db=m Differential binding of BvgA to two classes of virulence genes of Bordetella pertussis directs promoter selectivity by RNA polymerase. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8866733&form=6&db=m cAMP signaling mechanisms with aging in rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8866857&form=6&db=m Facilitation of T-type calcium current in bullfrog atrial cells: voltage-dependent relief of a G protein inhibitory tone. causal interaction,ongoing research,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8866863&form=6&db=m A non-inactivating K+ current sensitive to muscarinic receptor activation in rat cultured cerebellar granule neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8868049&form=6&db=m A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8868254&form=6&db=m Adenosine inhibits L- and N-type calcium channels in pituitary melanotrophs. Evidence for the involvement of a G protein in calcium channel gating. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8869079&form=6&db=m P2U-purinergic receptor activation mediates inhibition of cAMP accumulation in cultured renal mesangial cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8872898&form=6&db=m Mouse astrocytes respond to the chemokines MCP-1 and KC, but reverse transcriptase-polymerase chain reaction does not detect mRNA for the KC or new MCP-1 receptor. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8874211&form=6&db=m Expression of pertussis toxin adenosine diphosphate-ribosyltransferase in a T-cell hybridoma reduces metastatic capacity. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8874220&form=6&db=m Recombinant human eotaxin induces oxygen radical production, Ca(2+)-mobilization, actin reorganization, and CD11b upregulation in human eosinophils via a pertussis toxin-sensitive heterotrimeric guanine nucleotide-binding protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8874810&form=6&db=m Potentiation by higenamine of the aconitine-induced positive chronotropic effect in isolated right atria of mice: the effects of cholera toxin, forskolin and pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8875332&form=6&db=m Characterization of the muscarinic receptor subtypes in the bovine corneal epithelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8876984&form=6&db=m Dopamine D2, receptor-mediated modulation of the GABAergic inhibition of substantia nigra pars reticulata neurons. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8878121&form=6&db=m Secretoneurin-induced in vitro chemotaxis of human monocytes is inhibited by pertussis toxin and an inhibitor of protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8878422&form=6&db=m G-protein alpha subunit Gi(alpha)2 mediates erythropoietin signal transduction in human erythroid precursors. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8878428&form=6&db=m Mechanisms of impaired beta-adrenoceptor-induced airway relaxation by interleukin-1beta in vivo in the rat. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8880891&form=6&db=m G-proteins in guinea pig airway smooth muscle: identification and functional involvement. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8880892&form=6&db=m Endotoxin tolerance impairs a pertussis-toxin-sensitive G-protein regulating tumour necrosis factor release by macrophages from tumour-bearing rats. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8880893&form=6&db=m Intracerebroventricular pertussis toxin enhances sensitivity to chemical convulsants and decreases the protective efficacy of carbamazepine in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8882634&form=6&db=m Stimulation by the nucleotides, ATP and UTP of mitogen-activated protein kinase in EAhy 926 endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8883034&form=6&db=m Calcium entry stimulated by swelling of Madin-Darby canine kidney cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8883916&form=6&db=m Mouse cerebellar GABAB participation in the expression of acute ethanol-induced ataxia and in its modulation by the cerebellar adenosinergic A1 system. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8884020&form=6&db=m Pharmacology of pertussis toxin B-oligomer. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8884779&form=6&db=m Noradrenergic potentiation of cerebellar Purkinje cell responses to GABA: cyclic AMP as intracellular intermediary. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8886401&form=6&db=m PK 11195 blockade of benzodiazepine-induced inhibition of forskolin-stimulated adenylate cyclase activity in the striatum. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8886402&form=6&db=m Neuropeptide Y Y2 receptor-mediated attenuation of neurogenic plasma extravasation acting through pertussis toxin-sensitive mechanisms. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8886407&form=6&db=m Pyrimidinoceptor-mediated activation of phospholipase C and phospholipase A2 in RAW 264.7 macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8887958&form=6&db=m Adenylyl cyclase activity in clonally derived human myoblast cultures: evidence for myoblast heterogeneity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8888689&form=6&db=m Selectively enhanced cellular signaling by Gi proteins in essential hypertension. G alpha i2, G alpha i3, G beta 1, and G beta 2 are not mutated. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8890301&form=6&db=m Characterization of dopamine receptors mediating inhibition of excitatory synaptic transmission in the rat hippocampal slice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8890457&form=6&db=m D2L, D2S, and D3 dopamine receptors stably transfected into NG108-15 cells couple to a voltage-dependent potassium current via distinct G protein mechanisms. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8890934&form=6&db=m Regulation of bradykinin-induced Ins(1,4,5)P3 formation by protein kinase C in human fibroblasts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8895327&form=6&db=m Transfer of thyroiditis, with syngeneic spleen cells sensitized with the human thyrotropin receptor, to naive BALB/c and NOD mice. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8895344&form=6&db=m Extracellular nucleotides act through P2U purinoceptors to elevate [Ca2+]i and enhance basic fibroblast growth factor-induced proliferation in sheep chondrocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8896362&form=6&db=m Activation of apical P2U purine receptors permits inhibition of adrenaline-evoked cyclic AMP accumulation in cultured equine sweat gland epithelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8896446&form=6&db=m A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8896527&form=6&db=m Acellular pertussis vaccines developed in Japan and their application for disease control. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8896608&form=6&db=m Thrombospondin modulates alpha v beta 3 function through integrin-associated protein. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8896831&form=6&db=m P2 purinoceptor-mediated inhibition of cyclic AMP accumulation in NG108-15 cells. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8897440&form=6&db=m Calcium signalling by G protein-coupled sphingolipid receptors in bovine aortic endothelial cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8897446&form=6&db=m Modulation of L-type Ca current by denopamine, a nonparenteral partial beta 1 stimulant, in rabbit ventricular cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8897827&form=6&db=m Mechanisms of ANG II-induced mitogenic responses: role of 12-lipoxygenase and biphasic MAP kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8897834&form=6&db=m TXA2 agonists inhibit high-voltage-activated calcium channels in rat hippocampal CA1 neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8897841&form=6&db=m Angiotensin II stimulates T-type Ca2+ channel currents via activation of a G protein, Gi. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8897861&form=6&db=m Decreased glucose-induced cAMP and insulin release in islets of diabetic rats: reversal by IBMX, glucagon, GIP. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8897915&form=6&db=m Histamine activates phospholipase C in human airway epithelial cells via a phorbol ester-sensitive pathway. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8898085&form=6&db=m In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8898087&form=6&db=m Galectin-3 stimulates uptake of extracellular Ca2+ in human Jurkat T-cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8898093&form=6&db=m Evidence that Arg-295, Glu-378, and Glu-380 are active-site residues of the ADP-ribosyltransferase activity of iota toxin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8898647&form=6&db=m Sodium, hydrogen antiporter activation by extracellular adenosine triphosphate in biliary epithelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8898962&form=6&db=m Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse V beta gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor V beta b and T cell receptor V beta a H-2b mice. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8899597&form=6&db=m Muscarine activates a nonselective cation current through a M3 muscarinic receptor subtype in rat dorsolateral septal nucleus neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8899617&form=6&db=m Alpha 2 adrenoceptor potentiates glycine receptor-mediated taurine response through protein kinase A in rat substantia nigra neurons. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8899618&form=6&db=m Alpha 1 adrenoceptor activation potentiates taurine response mediated by protein kinase C in substantia nigra neurons. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8899711&form=6&db=m Preferential processing of the S1 subunit of pertussis toxin that is bound to eukaryotic cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8899823&form=6&db=m Atrial natriuretic peptide (ANP)-induced inhibition of glucagon secretion: mechanism of action in isolated rat pancreatic islets. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8902851&form=6&db=m 1,25(OH)2-vitamin D3 stimulation of phospholipases C and D in muscle cells involves extracellular calcium and a pertussis-sensitive G protein. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8902880&form=6&db=m Recovery of endothelium-dependent relaxations four weeks after ischemia and progressive reperfusion in canine coronary arteries. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8903323&form=6&db=m Bradykinin stimulates NF-kappaB activation and interleukin 1beta gene expression in cultured human fibroblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8905334&form=6&db=m Norepinephrine attenuates serotonin inhibition of pial venous tone. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8905470&form=6&db=m Regulation of mouse placental lactogen secretion by G proteins before midpregnancy. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8906560&form=6&db=m Inositol trisphosphate/Ca2+ as messengers of bradykinin B2 and muscarinic acetylcholine m1-m4 receptors in neuroblastoma-derived hybrid cells. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8906847&form=6&db=m Stimulating properties of 5-oxo-eicosanoids for human monocytes: synergism with monocyte chemotactic protein-1 and -3. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8908595&form=6&db=m Regulation of melanoma cell adhesion stabilization to fibronectin. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8910228&form=6&db=m Substance P suppresses GABAA receptor function via protein kinase C in primary sensory neurones of bullfrogs. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8910232&form=6&db=m Protein kinase C-mediated enhancement of glycine response in rat sacral dorsal commissural neurones by serotonin. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8912639&form=6&db=m Inhibition of adenylyl cyclases by 12(S)-hydroxyeicosatetraenoic acid. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8913359&form=6&db=m Membrane-delimited G protein-mediated coupling between V1a vasopressin receptor and dihydropyridine binding sites in rat glomerulosa cells. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8914015&form=6&db=m Signaling pathways in the biphasic effect of angiotensin II on apical Na/H antiport activity in proximal tubule. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8914576&form=6&db=m Cloning and functional expression of a cDNA encoding a mouse type 2 neuropeptide Y receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8914760&form=6&db=m Collaborative study for the evaluation of enzyme-linked immunosorbent assays used to measure human antibodies to Bordetella pertussis antigens. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8915575&form=6&db=m Regional differences of the inhibition of GABAB ligand binding by the GTP analogue Gpp(NH)p. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8917236&form=6&db=m Clinical experience of a tricomponent acellular pertussis vaccine combined with diphtheria and tetanus toxoids for primary vaccination in 22,505 infants. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8920914&form=6&db=m The angiotensin II type 2 receptor primarily inhibits cell growth via pertussis toxin-sensitive G proteins. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8920977&form=6&db=m Store-activated Ca2+ inflow in Xenopus laevis oocytes: inhibition by primaquine and evaluation of the role of membrane fusion. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8921248&form=6&db=m Opioid inhibition of Ca2+ channel subtypes in bovine chromaffin cells: selectivity of action and voltage-dependence. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8922387&form=6&db=m Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8922724&form=6&db=m Influence of pertussis toxin on the calcitonin-opioid interaction in isolated tissues. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8925276&form=6&db=m Muscarinic receptor-dependent activation of phospholipase C in human fetal central nervous system organotypic tissue culture. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8926063&form=6&db=m Analysis of proteins encoded by the ptx and ptl genes of Bordetella bronchiseptica and Bordetella parapertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8926072&form=6&db=m Pertussis-specific cell-mediated immunity in infants after vaccination with a tricomponent acellular pertussis vaccine. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8926085&form=6&db=m Expression and immunogenicity of pertussis toxin S1 subunit-tetanus toxin fragment C fusions in Salmonella typhi vaccine strain CVD 908. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8926282&form=6&db=m Predominant expression of type II vasoactive intestinal peptide receptors by human T lymphoblastoma cells: transduction of both Ca2+ and cyclic AMP signals. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8928788&form=6&db=m Extracellular ATP mediates Ca2+ signaling in cultured myenteric neurons via a PLC-dependent mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8928821&form=6&db=m Tannin stimulates arachidonic acid release from bovine tracheal epithelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8928871&form=6&db=m Characterization of a stimulatory adenosine A2a receptor in adult rat ventricular myocyte. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8930255&form=6&db=m Metabotropic glutamate receptor agonist-induced hyperpolarizations in rat basolateral amygdala neurons: receptor characterization and ion channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8930294&form=6&db=m Three distinct G protein pathways mediate inhibition of neuronal calcium current by bradykinin. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8930892&form=6&db=m Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8931489&form=6&db=m Stimulation of guanosine 5'-O-(3-[35S] thiotriphosphate) binding by cholinergic muscarinic receptors in membranes of rat olfactory bulb. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8935329&form=6&db=m Spontaneous and drug-stimulated locomotor activity after the administration of pertussis toxin into the ventral tegmental area. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8937431&form=6&db=m Relation of the [3H] gamma-hydroxybutyric acid (GHB) binding site to the gamma-aminobutyric acidB (GABAB) receptor in rat brain. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8937721&form=6&db=m Mechanisms of L-NG nitroarginine/indomethacin-resistant relaxation in bovine and porcine coronary arteries. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8937724&form=6&db=m Alpha-adrenoceptor mediated responses of the cauda epididymis of the guinea-pig. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8938654&form=6&db=m Endothelin-induced inositol phosphate formation in rat kidney. Studies on receptor subtypes, G-proteins and regulation during ontogenesis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8938664&form=6&db=m Opioid receptor agonists activate pertussis toxin-sensitive G proteins and inhibit adenylyl cyclase in canine cardiac sarcolemma. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8938725&form=6&db=m Somatostatin stimulates BKCa channels in rat pituitary tumor cells through lipoxygenase metabolites of arachidonic acid. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8939861&form=6&db=m Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8940109&form=6&db=m Purification and G protein subunit regulation of a phospholipase C-beta from Xenopus laevis oocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8940184&form=6&db=m Evidence for a ninth gene, ptlI, in the locus encoding the pertussis toxin secretion system of Bordetella pertussis and formation of a PtlI-PtlF complex. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8940250&form=6&db=m Heterotrimeric G-proteins are implicated in the regulation of apoptosis in pancreatic beta-cells. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8940338&form=6&db=m alpha2-Adrenoceptor stimulation promotes actin polymerization and focal adhesion in 3T3F442A and BFC-1beta preadipocytes. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8940379&form=6&db=m Effects of hypothyroidism on brown adipose tissue adenylyl cyclase activity. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8940408&form=6&db=m Activation of LH receptors expressed in GnRH neurons stimulates cyclic AMP production and inhibits pulsatile neuropeptide release. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8941070&form=6&db=m Inhibition of G protein in human sperm and its influence on acrosome reaction and zona pellucida binding. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8941649&form=6&db=m Defective regulation of phosphatidylcholine-specific phospholipases C and D in a kindred with Tangier disease. Evidence for the involvement of phosphatidylcholine breakdown in HDL-mediated cholesterol efflux mechanisms. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8943487&form=6&db=m Pathways through which glucose induces a rise in [Ca2+]i of polymorphonuclear leukocytes of rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8943730&form=6&db=m Stem cell factor potentiates histamine secretion by multiple mechanisms, but does not affect tumour necrosis factor-alpha release from rat mast cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8945090&form=6&db=m Muscarinic effects on action potential duration and its rate dependence in canine Purkinje fibers. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8945580&form=6&db=m Interleukin-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting induction of Th1 cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8945904&form=6&db=m Neuropeptide Y reduces macromolecule permeability of coronary endothelial monolayers. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8947471&form=6&db=m Bombesin and thrombin affect discrete pools of intracellular calcium through different G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8947479&form=6&db=m Activation of mitogen-activated protein kinase couples neurotensin receptor stimulation to induction of the primary response gene Krox-24. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8947492&form=6&db=m Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse delta opioid receptor in Rat-1 fibroblasts: effects of receptor expression levels and comparisons with G-protein activation. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8947493&form=6&db=m Kinetic and biochemical correlation between sustained p44ERK1 (44 kDa extracellular signal-regulated kinase 1) activation and lysophosphatidic acid-stimulated DNA synthesis in Rat-1 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8948324&form=6&db=m Theileria parva sporozoite entry into bovine lymphocytes involves both parasite and host cell signal transduction processes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8950096&form=6&db=m Cholera and pertussis toxins reveal multiple regulation of cAMP levels in the rabbit carotid body. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8950556&form=6&db=m Protective role of immunoglobulin G antibodies to filamentous hemagglutinin and pertactin of Bordetella pertussis in Bordetella parapertussis infection. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8951035&form=6&db=m Signaling responses to alkyllysophosphatidic acid: the activation of phospholipases A2 and C and protein tyrosine phosphorylation in human platelets. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8952694&form=6&db=m Pertussis toxin-insensitive effects of mastoparan, a wasp venom peptide, in PC12 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8952700&form=6&db=m 24,25-(OH)2D3 regulates protein kinase C through two distinct phospholipid-dependent mechanisms. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8952703&form=6&db=m Purinergic agonists stimulate the secretion of endothelin-1 in rat thyroid FRTL-5 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8954829&form=6&db=m Tissue plasminogen activator increases canine endothelial cell proliferation rate through a plasmin-independent, receptor-mediated mechanism. causal interaction,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8955154&form=6&db=m Differential translocation of rho family GTPases by lysophosphatidic acid, endothelin-1, and platelet-derived growth factor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8955177&form=6&db=m Preferential involvement of Go and Gz proteins in mediating rat natural killer cell lysis of allogeneic and tumor target cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8957249&form=6&db=m Omega-agatoxin IVA blocks spinal morphine/clonidine antinociceptive synergism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8957696&form=6&db=m Voltage-dependent calcium channels and Gi regulatory protein mediate the human sperm acrosomal exocytosis induced by N-acetylglucosaminyl/mannosyl neoglycoproteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8958444&form=6&db=m Evidence for the presence of G-proteins, adenylyl cyclase and phospholipase C activities in lymphatic smooth muscle cell membranes. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8958558&form=6&db=m Studies on pyrazinoylguanidine. 3. Downregulation of lipolysis in isolated adipocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8960976&form=6&db=m Muscarinic and purinergic Ca2+ mobilizations in the neural retina of early embryonic chick. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8961182&form=6&db=m Modulation of the muscarinic K+ channel by P2-purinoceptors in guinea-pig atrial myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8961278&form=6&db=m G proteins of the Gq family couple the H2 histamine receptor to phospholipase C. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8963646&form=6&db=m Long-term depression of a sympathetic ganglionic response to opioids by prolonged synaptic activity and by phorbol esters. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8963948&form=6&db=m ATP shortens atrial action potential duration in the dog: role of adenosine, the vagus nerve, and G protein. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8963956&form=6&db=m Mechanism of epinephrine-induced dysrhythmias in rat involves local cholinergic activation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8964080&form=6&db=m CD69-induced monocyte apoptosis involves multiple nonredundant signaling pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8964834&form=6&db=m Multiple G proteins and phospholipase C isoforms in human myometrial cells: implication for oxytocin action. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8964835&form=6&db=m Fluprostenol activates phospholipase C and Ca2+ mobilization in human myometrial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8967472&form=6&db=m Properties of AT1a and AT1b angiotensin receptors expressed in adrenocortical Y-1 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8967989&form=6&db=m Inverse agonistic effect of ICI-174,864 on the cloned delta-opioid receptor: role of G protein and adenylyl cyclase activation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8968327&form=6&db=m Acute and chronic effects of dexfenfluramine on the porcine coronary artery. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8968332&form=6&db=m Potentiation of the glycine-activated Cl- current by ethanol in cultured mouse spinal neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8968547&form=6&db=m The P2Y purinoceptor in rat brain microvascular endothelial cells couple to inhibition of adenylate cyclase. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8968962&form=6&db=m Studies on the characterization of the subtype(s) of muscarinic receptor involved in prostacyclin synthesis in rabbit cardiomyocytes. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8969228&form=6&db=m Activation of MEKK by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Mapping pathways for mitogen-activated protein kinase activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8970151&form=6&db=m Dissociation of mitogen-activated protein kinase activation from p125 focal adhesion kinase tyrosine phosphorylation in Swiss 3T3 cells stimulated by bombesin, lysophosphatidic acid, and platelet-derived growth factor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8971917&form=6&db=m Could dual G-protein coupling explain [D-Met2]FMRFamide's mixed action in vivo? causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8972723&form=6&db=m Pertussis toxin reverses the inhibition of the adenylyl cyclase system by khellin in HeLa cells. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8973553&form=6&db=m Characterization of heterotrimeric G-proteins in adult Acanthocheilonema viteae. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8973567&form=6&db=m Activation effects of a prion protein fragment [PrP-(106-126)] on human leucocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8973773&form=6&db=m Modulation of cardiac cell Ca2+ currents by PAF. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8973818&form=6&db=m M-current suppression in PC12 cells by bradykinin is mediated by a pertussis toxin-insensitive G-protein and modulated by intracellular calcium. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8977215&form=6&db=m Mouse bone marrow-derived mast cells undergo exocytosis, prostanoid generation, and cytokine expression in response to G protein-activating polybasic compounds after coculture with fibroblasts in the presence of c-kit ligand. diagnostic usage,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8977407&form=6&db=m Sphingosine 1-phosphate stimulates hydrogen peroxide generation through activation of phospholipase C-Ca2+ system in FRTL-5 thyroid cells: possible involvement of guanosine triphosphate-binding proteins in the lipid signaling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8977429&form=6&db=m The Mel1a melatonin receptor is coupled to parallel signal transduction pathways. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8978280&form=6&db=m Arachidonic acid mediates interferon-gamma-induced sphingomyelin hydrolysis and monocytic marker expression in HL-60 cell line. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8978316&form=6&db=m Mechanisms of coronary microvascular dilation induced by the activation of pertussis toxin-sensitive G proteins are vessel-size dependent. Heterogeneous involvement of nitric oxide pathway and ATP-sensitive K+ channels. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8978351&form=6&db=m Peptide YY inhibition of rat gastric enterochromaffin-like cell function. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8978712&form=6&db=m Endothelin stimulates phospholipase D in striatal astrocytes. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8979346&form=6&db=m Stable expression of pertussis toxin in Bordetella bronchiseptica under the control of a tightly regulated promoter. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8980183&form=6&db=m Effects of human fibroblasts on invasiveness of oral cancer cells in vitro: isolation of a chemotactic factor from human fibroblasts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8980284&form=6&db=m Interleukin-1beta-induced inhibition of hair growth in vitro is mediated by cyclic AMP. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8980298&form=6&db=m Chemotactic 5-oxo-eicosatetraenoic acids induce oxygen radical production, Ca2+-mobilization, and actin reorganization in human eosinophils via a pertussis toxin-sensitive G-protein. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8982657&form=6&db=m Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8982672&form=6&db=m Receptor and mechanism that mediate endothelin- and big endothelin-1-induced phosphoinositide hydrolysis in the rat spinal cord. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8987784&form=6&db=m Mechanisms of C5a and C3a complement fragment-induced [Ca2+]i signaling in mouse microglia. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8989408&form=6&db=m Muscarine inhibits omega-conotoxin-sensitive calcium channels in a voltage- and time-dependent mode in the human neuroblastoma cell line SH-SY5Y. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8989431&form=6&db=m The lymphocytosis-promoting agent pertussis toxin affects virus burden and lymphocyte distribution in the SIV-infected rhesus macaque. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8990625&form=6&db=m Regulation of neutrophil O2- production by neutrophil-endothelial cell interaction via CD11b: its modulation by tumor necrosis factor-alpha (TNF-alpha) and lipopolysaccharide (LPS). therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8991801&form=6&db=m Neuropeptide Y inhibits depolarization-stimulated catecholamine synthesis in rat pheochromocytoma cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8994049&form=6&db=m N-ethylmaleimide blocks depolarization-induced suppression of inhibition and enhances GABA release in the rat hippocampal slice in vitro. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8994056&form=6&db=m Mediation by protein kinases C and A of Go-linked slow responses of enteric neurons to 5-HT. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8994064&form=6&db=m Novel modulatory effect of L-type calcium channels at newly formed neuromuscular junctions. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8994437&form=6&db=m Angiotensin II inhibits protein kinase A-dependent chloride conductance in heart via pertussis toxin-sensitive G proteins. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8995289&form=6&db=m Up-regulation of the alpha2-macroglobulin signaling receptor on rheumatoid synovial fibroblasts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8995363&form=6&db=m The heterotrimeric G protein G alpha i2 mediates lysophosphatidic acid-stimulated induction of the c-fos gene in mouse fibroblasts. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8995431&form=6&db=m Pasteurella multocida toxin activates the inositol triphosphate signaling pathway in Xenopus oocytes via G(q)alpha-coupled phospholipase C-beta1. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8995450&form=6&db=m Differential effect of shear stress on extracellular signal-regulated kinase and N-terminal Jun kinase in endothelial cells. Gi2- and Gbeta/gamma-dependent signaling pathways. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8996236&form=6&db=m Chronic morphine treatment increases stimulatory beta-2 adrenoceptor signaling in A431 cells stably expressing the mu opioid receptor. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8996247&form=6&db=m The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8997178&form=6&db=m Mechanisms of inhibition of insulin release. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8997256&form=6&db=m Pertussis toxin alters the concentration and turnover of manganese superoxide dismutase in rat lung. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8997625&form=6&db=m Pharmacological characterization of the human P2Y4 receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9000430&form=6&db=m Inhibition of the L-type calcium channel by the five muscarinic receptors (m1-m5) expressed in NIH 3T3 cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9001733&form=6&db=m Etorphine elicits anomalous excitatory opioid effects on sensory neurons treated with GM1 ganglioside or pertussis toxin in contrast to its potent inhibitory effects on naive or chronic morphine-treated cells. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9001889&form=6&db=m Mechanism of induction of prostaglandin E2 production by endothelin 1 in cultured rat mesangial cells. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9002988&form=6&db=m Cryptic gonadotropin-releasing hormone receptors of rat pituitary cells in culture are unmasked by epidermal growth factor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9002996&form=6&db=m Melatonin action and signal transduction in the rat suprachiasmatic circadian clock: activation of protein kinase C at dusk and dawn. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9003394&form=6&db=m Progesterone and the zona pellucida activate different transducing pathways in the sequence of events leading to diacylglycerol generation during mouse sperm acrosomal exocytosis. diagnostic usage,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9007835&form=6&db=m Signalling properties of lysophosphatidic acid in primary human skin fibroblasts: role of pertussis toxin-sensitive GTP-binding proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9008648&form=6&db=m Identification of G-protein alpha-subunits during distinct stages of lens cell differentiation. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9011762&form=6&db=m G alpha q/11 mediates neurotensin excitation of substantia nigra dopaminergic neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9013403&form=6&db=m Antipsychotics with inverse agonist activity at the dopamine D3 receptor. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9013884&form=6&db=m The C-terminal domain of the Gs-coupled EP4 receptor confers agonist-dependent coupling control to Gi but no coupling to Gs in a receptor hybrid with the Gi-coupled EP3 receptor. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9014140&form=6&db=m Effects of the nootropic drug nefiracetam on the GABAA receptor-channel complex in dorsal root ganglion neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9015764&form=6&db=m Multiple G-protein involvement in parathyroid hormone regulation of acid production by osteoclasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9015861&form=6&db=m Functional reconstitution of detergent-solubilized bovine calf testis luteinizing hormone/chorionic gonadotropin receptor into phospholipid vesicles. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9016358&form=6&db=m Agonist activation of delta-opioid receptor but not mu-opioid receptor potentiates fetal calf serum or tyrosine kinase receptor-mediated cell proliferation in a cell-line-specific manner. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9017600&form=6&db=m Role of gelsolin in actin depolymerization of adherent human neutrophils. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9018382&form=6&db=m Guanine nucleotide binding proteins in opioid-dependent patients. causal interaction,diagnostic usage,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9019728&form=6&db=m Role of G-proteins in the regulation of organic osmolyte efflux from isolated rat renal inner medullary collecting duct cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9022074&form=6&db=m Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9022678&form=6&db=m Activation of signaling pathways in HL60 cells and human neutrophils by farnesylthiosalicylate. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9023011&form=6&db=m Involvement of a pertussis-toxin sensitive G protein in the induction of gene expression by insulin. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9026357&form=6&db=m Role of kinases and G-proteins on arachidonate release induced by zymosan in mouse peritoneal macrophages. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9027539&form=6&db=m Whooping cough and Parkinson's disease. The Europarkinson Preparatory Activity Research Group. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9029482&form=6&db=m Interactions of alpha-melanotropin and agouti on B16 melanoma cells: evidence for inverse agonism of agouti. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9030557&form=6&db=m Activation of a calcium-permeable cation channel CD20 expressed in Balb/c 3T3 cells by insulin-like growth factor-I. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9030595&form=6&db=m Basolateral localization and transcytosis of gonadotropin and thyrotropin receptors expressed in Madin-Darby canine kidney cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9030641&form=6&db=m Metabotropic glutamate receptor activation modulates kainate and serotonin calcium response in astrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9030903&form=6&db=m High carbachol increases the electrically induced [Ca2+]i transient in the single isolated ventricular myocyte of rats. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9031749&form=6&db=m Neuropeptide Y Y2 receptor and somatostatin sst2 receptor coupling to mobilization of intracellular calcium in SH-SY5Y human neuroblastoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9031875&form=6&db=m Comparative safety and immunogenicity of an acellular versus whole-cell pertussis component of diphtheria-tetanus-pertussis vaccines in Senegalese infants. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9032437&form=6&db=m Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9032459&form=6&db=m Interactions of the alpha2A-adrenoceptor with multiple Gi-family G-proteins: studies with pertussis toxin-resistant G-protein mutants. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9032468&form=6&db=m Differential regulation of extracellular signal-regulated protein kinase 1 and Jun N-terminal kinase 1 by Ca2+ and protein kinase C in endothelin-stimulated Rat-1 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9032903&form=6&db=m Expression and secretion of the S2 subunit of pertussis toxin in Bacillus brevis. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9034171&form=6&db=m Studies of the renal action of melatonin: evidence that the effects are mediated by 37 kDa receptors of the Mel1a subtype localized primarily to the basolateral membrane of the proximal tubule. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9037083&form=6&db=m Modulation by neurotransmitters of catecholamine secretion from sympathetic ganglion neurons detected by amperometry. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9038193&form=6&db=m Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9038326&form=6&db=m Role of pertussis toxin A subunit in neutrophil migration and vascular permeability. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9038367&form=6&db=m Functional expression, activation and desensitization of opioid receptor-like receptor ORL1 in neuroblastoma x glioma NG108-15 hybrid cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9038726&form=6&db=m Diadenosine polyphosphates induce intracellular Ca2+ mobilization in human neutrophils via a pertussis toxin sensitive G-protein. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9038845&form=6&db=m Effect of in vivo injection of cholera and pertussis toxin on glucose transport in rat skeletal muscle. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9038931&form=6&db=m Endothelin ETA receptor regulates signaling and ANF gene expression via multiple G protein-linked pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9038953&form=6&db=m Modulation of ATP-sensitive K+ channels in rabbit ventricular myocytes by adenosine A1 receptor activation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9039845&form=6&db=m Defective myogenesis in NFB-s mutant associated with a saturable suppression of MYF5 activity. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9039962&form=6&db=m The G-protein G(i) regulates mitosis but not DNA synthesis in growth factor-activated fibroblasts: a role for the nuclear translocation of G(i). causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9040484&form=6&db=m Pharmacologic evidence for 5-HT1A receptors associated with human retinal pigment epithelial cells in culture. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9041597&form=6&db=m Unchanged efficacy of a pertussis toxoid vaccine throughout the two years after the third vaccination of infants. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9041666&form=6&db=m Effect of schedule on reactogenicity and antibody persistence of acellular and whole-cell pertussis vaccines: value of laboratory tests as predictors of clinical performance. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9042382&form=6&db=m An examination of the relationship between mu-opioid antinociceptive efficacy and G-protein coupling using pertussis and cholera toxins. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9045838&form=6&db=m Nature of DNA binding and RNA polymerase interaction of the Bordetella pertussis BvgA transcriptional activator at the fha promoter. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9046355&form=6&db=m Signal transduction in human myometrial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9046428&form=6&db=m Pertussis toxin pretreatment alters the in vivo cell division behaviour and survival of B lymphocytes after intravenous transfer. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9048595&form=6&db=m Short-term inhibitory effect of somatostatin on gastric histamine synthesis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9048603&form=6&db=m Activation of G proteins mediates flow-induced prostaglandin E2 production in osteoblasts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9048747&form=6&db=m Identification of a neuronal cell surface receptor for a growth inhibitory chondroitin sulfate proteoglycan (NG2). causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9049143&form=6&db=m Mu and delta opioid receptor activation inhibits omega-conotoxin-sensitive calcium channels in a voltage- and time-dependent mode in the human neuroblastoma cell line SH-SY5Y. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9051575&form=6&db=m Exotoxin-insensitive G proteins mediate synaptically evoked muscarinic sodium current in rabbit sympathetic neurones. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9054386&form=6&db=m Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9054456&form=6&db=m Protein-tyrosine phosphatase SHP2 is positively linked to proteinase-activated receptor 2-mediated mitogenic pathway. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9054580&form=6&db=m Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9056746&form=6&db=m Effects of human low-density lipoproteins on superoxide production by formyl-methionyl-leucyl-phenylalanine activated polymorphonuclear leukocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9057024&form=6&db=m The role of the S-1 and B-oligomer components of pertussis toxin in its adjuvant properties for Th1 and Th2 cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9057099&form=6&db=m Different mechanisms are involved in intracellular calcium increase by insulin-like growth factors 1 and 2 in articular chondrocytes: voltage-gated calcium channels, and/or phospholipase C coupled to a pertussis-sensitive G-protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9058053&form=6&db=m GP55 inhibits both cell adhesion and growth of neurons, but not non-neuronal cells, via a G-protein-coupled receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9059535&form=6&db=m Endothelin-1 inhibition of cardiac ATP-sensitive K+ channels via pertussis-toxin-sensitive G-proteins. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9059557&form=6&db=m Intracellular calcium ion responses to somatostatin in cells from human somatotroph adenomas. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9060456&form=6&db=m Undifferentiated U937 cells transfected with chemoattractant receptors: a model system to investigate chemotactic mechanisms and receptor structure/function relationships. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9061004&form=6&db=m Suppression of the voltage-gated K+ current of human megakaryocytes by thrombin and prostacyclin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9061643&form=6&db=m Rebound stimulation of the cAMP-regulated Cl- current by acetylcholine in guinea-pig ventricular myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9062356&form=6&db=m Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9062681&form=6&db=m Cellular mechanisms underlying cognition-enhancing actions of nefiracetam (DM-9384). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9063694&form=6&db=m Both GABAA and GABAB receptors participate in suppression of [CA2+]i pulsing in toad melanotrophs. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9063696&form=6&db=m Bromocriptine stimulates Na+, K(+)-ATPase in renal proximal tubules via the cAMP pathway. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9064639&form=6&db=m Arachidonic acid as a second messenger for hypotonicity-induced calcium transients in rat IMCD cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9065184&form=6&db=m Gi protein activation of gonadotropin-releasing hormone-mediated protein dephosphorylation in human endometrial carcinoma. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9065439&form=6&db=m 5-HT1A receptor activates Na+/H+ exchange in CHO-K1 cells through Gialpha2 and Gialpha3. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9065843&form=6&db=m Distinct muscarinic receptor subtypes suppress excitatory and inhibitory synaptic responses in cortical neurons. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9066531&form=6&db=m Nitric oxide and G proteins mediate the response of bovine articular chondrocytes to fluid-induced shear. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9066783&form=6&db=m Evidence for a role of G protein beta gamma subunits in the enhancement of cAMP accumulation and DNA synthesis by adenosine in human cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9067474&form=6&db=m Enhancement of the locomotor response to apomorphine in pertussis toxin-treated animals depends on the site of pertussis toxin injection into the ventral tegmental area. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9067639&form=6&db=m Evidence that thrombin-stimulated DNA synthesis in pulmonary arterial fibroblasts involves phosphatidylinositol 3-kinase-dependent p70 ribosomal S6 kinase activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9069580&form=6&db=m Immunomodulation of murine experimental autoimmune encephalomyelitis by pertussis toxin: the protective activity, but not the disease-enhancing activity, can be attributed to the nontoxic B-oligomer. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9069588&form=6&db=m Thrombin and trypsin induce granulocyte-macrophage colony-stimulating factor and interleukin-6 gene expression in cultured normal human keratinocytes. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9071017&form=6&db=m Molecular cloning of heterotrimeric G-protein alpha-subunits in chicken pineal gland. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9071968&form=6&db=m Regulation of lipolysis by somatotropin: functional alteration of adrenergic and adenosine signaling in bovine adipose tissue. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9075338&form=6&db=m Phospholipase D activity in the Tetrahymena pyriformis GL. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9077584&form=6&db=m Time-dependent effects of in vivo pertussis toxin on morphine analgesia and G-proteins in mice. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9080938&form=6&db=m Cell-mediated and antibody responses to Bordetella pertussis antigens in children vaccinated with acellular or whole-cell pertussis vaccines. The Progetto Pertosse-CMI Working Group. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9081621&form=6&db=m Decrease in [Ca2+]c but not in cAMP Mediates L-AP4 inhibition of glutamate release: PKC-mediated suppression of this inhibitory pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9083779&form=6&db=m Modulation of [3H]dopamine release by neuropeptide Y in rat striatal slices. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9083789&form=6&db=m Transfected adenosine A1 receptor-mediated modulation of thrombin-stimulated phospholipase C and phospholipase A2 activity in CHO cells. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9084434&form=6&db=m Two distinct P2 purinergic receptors, P2Y and P2U, are coupled to phospholipase C in mouse pineal gland tumor cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9084602&form=6&db=m Effects of serotonin on caudal raphe neurons: activation of an inwardly rectifying potassium conductance. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9084603&form=6&db=m Effects of serotonin on caudal raphe neurons: inhibition of N- and P/Q-type calcium channels and the afterhyperpolarization. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9084607&form=6&db=m Modulation of high-voltage activated Ca2+ channels in the rat periaqueductal gray neurons by mu-type opioid agonist. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9088658&form=6&db=m Immune effector cells induced by complete Freund's adjuvant exert an inhibitory effect on antigen-specific type 2 T helper responses. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9092559&form=6&db=m Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9092561&form=6&db=m The P2U purinoceptor obligatorily engages the heterotrimeric G protein G16 to mobilize intracellular Ca2+ in human erythroleukemia cells. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9092802&form=6&db=m Inhibition of the T-type Ca2+ current by the dopamine D1 receptor in rat adrenal glomerulosa cells: requirement of the combined action of the G betagamma protein subunit and cyclic adenosine 3',5'-monophosphate. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9094259&form=6&db=m GABAB-mediated upregulation of the high-voltage-activated Ca2+ channels in rat dorsal root ganglia. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9096246&form=6&db=m Lysophosphatidic acid sensitizes mechanical stress-induced Ca2+ response via activation of phospholipase C and tyrosine kinase in cultured smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9096257&form=6&db=m Interaction of D2-dopamine receptor with two pertussis toxin sensitive G proteins in human placenta. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9097934&form=6&db=m Restoration of the transient outward potassium current by noradrenaline in chagasic canine epicardium. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9099903&form=6&db=m Multiple G-protein coupling of the dog thyrotropin receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9101406&form=6&db=m Positive and negative coupling of the metabotropic glutamate receptors to a G protein-activated K+ channel, GIRK, in Xenopus oocytes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9103241&form=6&db=m MCP-1-mediated chemotaxis requires activation of non-overlapping signal transduction pathways. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9103475&form=6&db=m Activation of phospholipase D by endothelin-1 in rat myometrium. Role of calcium and protein kinase C. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9103543&form=6&db=m Opioids binding mu and delta receptors exhibit diverse efficacy in the activation of Gi2 and G(x/z) transducer proteins in mouse periaqueductal gray matter. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9106632&form=6&db=m Structure/function relationships of calcitonin analogues as agonists, antagonists, or inverse agonists in a constitutively activated receptor cell system. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9108406&form=6&db=m C3a and C5a stimulate chemotaxis of human mast cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9108861&form=6&db=m Reactogenicity and immunogenicity of a booster dose of a combined diphtheria, tetanus, and tricomponent acellular pertussis vaccine at fourteen to twenty-eight months of age. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9109161&form=6&db=m Pertussis: current concepts of pathogenesis and prevention. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9109163&form=6&db=m Comparative efficacy of acellular pertussis vaccines: an analysis of recent trials. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9109509&form=6&db=m Differential agonist regulation of the human kappa-opioid receptor. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9109661&form=6&db=m Kinetic isotope effect characterization of the transition state for oxidized nicotinamide adenine dinucleotide hydrolysis by pertussis toxin. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9111036&form=6&db=m Extracellular calcium and platelet-derived growth factor promote receptor-mediated chemotaxis in osteoblasts through different signaling pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9111066&form=6&db=m Bromocriptine transcriptionally activates the multidrug resistance gene (pgp2/mdr1b) by a novel pathway. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9112392&form=6&db=m Mastoparan-stimulated prolactin secretion in rat pituitary GH3 cells involves activation of Gq/11 proteins. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9113103&form=6&db=m Inhibition of swine microglial cell phagocytosis of Cryptococcus neoformans by femtomolar concentrations of morphine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9113381&form=6&db=m The involvement of pertussis toxin-sensitive G proteins in the post receptor mechanism of central I1-imidazoline receptors. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9113416&form=6&db=m Melatonin agonists induce phosphoinositide hydrolysis in Xenopus laevis melanophores. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9115254&form=6&db=m RGS4 inhibits Gq-mediated activation of mitogen-activated protein kinase and phosphoinositide synthesis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9117097&form=6&db=m Somatostatin receptors in Neuro2A neuroblastoma cells: operational characteristics. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9117098&form=6&db=m Somatostatin receptors in Neuro2A neuroblastoma cells: ligand internalization. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9119893&form=6&db=m Hormone-defined cell system for studying G-protein coupled receptor agonist-activated growth modulation: delta-opioid and serotonin-5HT2C receptor activation show opposite mitogenic effects. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9121363&form=6&db=m In vivo pharmacology of butylthio[2.2.2] (LY297802 / NNC11-1053), an orally acting antinociceptive muscarinic agonist. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9121612&form=6&db=m Serotonin modulates high-voltage-activated Ca2+ channels in rat ventromedial hypothalamic neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9121737&form=6&db=m G protein specificity of the muscarine-induced increase in an inward rectifier potassium current in AtT-20 cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9124299&form=6&db=m Pertussis toxin, but not tyrosine kinase inhibitors, abolishes effects of U-50488H on [Ca2+]i in myocytes. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9124373&form=6&db=m Muscarinic-induced mucin secretion and intracellular signaling by hamster tracheal goblet cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9124407&form=6&db=m G alpha(i-2) mediates renal LLC-PK1 growth by a Raf-independent activation of p42/p44 MAP kinase. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9124441&form=6&db=m Opioid peptide receptor stimulation reverses beta-adrenergic effects in rat heart cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9124507&form=6&db=m Sphingosine 1-phosphate stimulates Na+/H+ exchange in thyroid FRTL-5 cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9124580&form=6&db=m Prostaglandins induce proliferation of rat hepatocytes through a prostaglandin E2 receptor EP3 subtype. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9126656&form=6&db=m Lysophosphatidic acid and intracellular signalling in vascular smooth muscle cells. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9127005&form=6&db=m Activation of Ras and mitogen-activated protein kinase pathway by terminal complement complexes is G protein dependent. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9129126&form=6&db=m Metabolic stimulation of mouse spleen lymphocytes by low doses of delta9-tetrahydrocannabinol. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9129212&form=6&db=m Chemoattractant properties of PR-39, a neutrophil antibacterial peptide. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9130050&form=6&db=m Experimental melanin-protein induced uveitis (EMIU) is the sole type of uveitis evoked by a diversity of ocular melanin preparations and melanin-derived soluble polypeptides. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9130251&form=6&db=m Immortalized schwann cells express endothelin receptors coupled to adenylyl cyclase and phospholipase C. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9131415&form=6&db=m Endothelial P2-purinoceptors: subtypes and signal transduction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9133523&form=6&db=m 'Cross talk' between opioid peptide and adrenergic receptor signaling in isolated rat heart. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9134028&form=6&db=m Novel method for following lymphocyte traffic in mice using [3H]glycerol labeling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9134231&form=6&db=m The effects of recombinant rat mu-opioid receptor activation in CHO cells on phospholipase C, [Ca2+]i and adenylyl cyclase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9134325&form=6&db=m Response to prejunctional adenosine receptors is dependent on stimulus frequency. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9136078&form=6&db=m Protein kinases A and C positively regulate G protein-dependent activation of phosphatidylinositol-specific phospholipase C by tumor necrosis factor-alpha in MC3T3-E1 osteoblasts. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9137989&form=6&db=m The antineoplastic drug vinorelbine activates non-immunological histamine release from rat mast cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9138685&form=6&db=m Stimulation by extracellular ATP and UTP of the stress-activated protein kinase cascade in rat renal mesangial cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9138726&form=6&db=m Mouse cerebellar adenosinergic modulation of ethanol-induced motor incoordination: possible involvement of cAMP. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9139796&form=6&db=m Induction of promiscuous G protein coupling of the follicle-stimulating hormone (FSH) receptor: a novel mechanism for transducing pleiotropic actions of FSH isoforms. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9139798&form=6&db=m Luteinizing hormone/choriogonadotropin-dependent, cholera toxin-catalyzed adenosine 5'-diphosphate (ADP)-ribosylation of the long and short forms of Gs alpha and pertussis toxin-catalyzed ADP-ribosylation of Gi alpha*. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9140804&form=6&db=m The role of Gi-proteins and beta-adrenoceptors in the age-related decline of contraction in guinea-pig ventricular myocytes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9140814&form=6&db=m Beta-adrenoceptor-linked signal transduction in ischemic-reperfused heart and scavenging of oxyradicals. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9140828&form=6&db=m Distinct components of morphine effects on cardiac myocytes are mediated by the kappa and delta opioid receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9140833&form=6&db=m Agonist-independent tonic inhibitory influence of Gi on adenylate cyclase activity in rabbit ventricular myocardium and its removal by pertussis toxin: a role of empty receptor-mediated Gi activation. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9141360&form=6&db=m Activation of inwardly rectifying potassium channels by muscarinic receptor-linked G protein in isolated human ventricular myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9142836&form=6&db=m Cholera and pertussis toxins increase acidification of endocytic vesicles without altering ion conductances. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9142842&form=6&db=m Modulation of voltage-dependent Ca2+ conductance by changing Cl- concentration in rat lactotrophs. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9142851&form=6&db=m Protein kinase A phosphorylation and G protein regulation of type II pneumocyte Na+ channels in lipid bilayers. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9142897&form=6&db=m Colonic smooth muscle cells possess a different subtype of somatostatin receptor from gastric smooth muscle cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9142901&form=6&db=m Molecular mechanisms for somatostatin inhibition of c-fos gene expression. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9142999&form=6&db=m Inhibitory effect of melatonin on gonadotropin-releasing hormone-induced Ca2+ oscillations in pituitary cells of newborn rats. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9144644&form=6&db=m The 5-HT1D receptor antagonist GR-127,935 prevents inhibitory effects of sumatriptan but not CP-122,288 and 5-CT on neurogenic plasma extravasation within guinea pig dura mater. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9144648&form=6&db=m Bradykinin inhibition of N- and L-type calcium channel currents in NG108-15 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9144658&form=6&db=m Dual modulation of an inwardly rectifying potassium conductance. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9146892&form=6&db=m Characterization of human recombinant somatostatin sst5 receptors mediating activation of phosphoinositide metabolism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9146895&form=6&db=m Trophic effect of angiotensin II in neonatal rat cardiomyocytes: role of endothelin-1 and non-myocyte cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9147032&form=6&db=m Effects of spinally and supraspinally injected 3-isobutyl-1-methylxanthine, cholera toxin, and pertussis toxin on cold water swimming stress-induced antinociception in the mouse. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9147372&form=6&db=m beta-Amyloid-induced IL-1 beta release from an activated human monocyte cell line is calcium- and G-protein-dependent. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9148895&form=6&db=m Phospholipase D activity in PC12 cells. Effects of overexpression of alpha2A-adrenergic receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9148952&form=6&db=m Regulation of mitogen-activated protein kinase phosphatase-1 expression by extracellular signal-related kinase-dependent and Ca2+-dependent signal pathways in Rat-1 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9150274&form=6&db=m Role of prostaglandin E2 in regulation of low and high water osmotic permeability in frog urinary bladder. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9150297&form=6&db=m Intrathecal pertussis toxin produces hyperalgesia and allodynia in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9151292&form=6&db=m Histamine H1 receptors in C6 glial cells are coupled to calcium-dependent potassium channels via release of calcium from internal stores. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9151723&form=6&db=m Somatostatin inhibits excitatory transmission at rat hippocampal synapses via presynaptic receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9152245&form=6&db=m Gs and Gq/11 couple vasoactive intestinal peptide and cholinergic stimulation to lacrimal secretion. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9153246&form=6&db=m Agonist-induced desensitization, internalization, and phosphorylation of the sst2A somatostatin receptor. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9153259&form=6&db=m Chemoattractant receptor-induced phosphorylation of L-selectin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9153590&form=6&db=m Development of G protein-mediated Ca2+ channel regulation in mouse embryonic stem cell-derived neurons. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9153637&form=6&db=m Serum uncouples elevation of cyclic adenosine monophosphate concentration from cyclic adenosine monophosphate dependent morphological changes exhibited by cultured pituicytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9154343&form=6&db=m Constitutive activity of human prostaglandin E receptor EP3 isoforms. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9156359&form=6&db=m Studies of the cellular mechanisms underlying the vasorelaxant effects of rutaecarpine, a bioactive component extracted from an herbal drug. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9157684&form=6&db=m Regulation of luminol-dependent chemiluminescence and degranulation by bovine neutrophils stimulated with opsonized zymosan. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9160737&form=6&db=m Alpha2-adrenergic receptor-mediated Ca2+ influx and release in porcine myometrial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9161717&form=6&db=m Modulation of sperm acrosomal exocytosis by guanyl nucleotides and G-protein-modifier agents. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9161988&form=6&db=m GABAB receptor-mediated inhibition of spontaneous inhibitory synaptic currents in rat midbrain culture. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9163480&form=6&db=m Molecular characterization of two Bordetella bronchiseptica strains isolated from children with coughs. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9164555&form=6&db=m Chronic treatment with dexmedetomidine desensitizes alpha 2-adrenergic signal transduction. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9166722&form=6&db=m Depolarization and activation of dihydropyridine-sensitive Ca2+ channels stimulate inositol phosphate accumulation in photoreceptor-enriched chick retinal cell cultures. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9166747&form=6&db=m Functional role of amino-terminal serine16 and serine27 of G alphaZ in receptor and effector coupling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9167008&form=6&db=m Collaborative study on test systems to assess toxicity of whole cell pertussis vaccine. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9167640&form=6&db=m G proteins and phospholipase C mediate thrombin-induced generation of plasminogen activator inhibitor-1 from vascular smooth muscle cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9167937&form=6&db=m Effects of respiratory burst inhibitors on nitric oxide production by human neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9169439&form=6&db=m Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9169747&form=6&db=m Vaccine- and antigen-dependent type 1 and type 2 cytokine induction after primary vaccination of infants with whole-cell or acellular pertussis vaccines. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9171237&form=6&db=m Regulation of G(q/11)alpha by the gonadotropin-releasing hormone receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9174358&form=6&db=m Alpha 2A-adrenergic receptor stimulated calcium release is transduced by Gi-associated G(beta gamma)-mediated activation of phospholipase C. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9174670&form=6&db=m Endocytosis and retrograde transport of pertussis toxin to the Golgi complex as a prerequisite for cellular intoxication. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9174984&form=6&db=m Use of type I and type IV hypersensitivity responses to define the immunopharmacological profile of drugs. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9175608&form=6&db=m Ontogenetic and pharmacological studies on metabotropic glutamate receptors coupled to phospholipase D activation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9175612&form=6&db=m Inhibition of AMPA receptor-stimulated 57Co2+ influx by D- and L-2-amino-4-phosphonobutanoic acid (D- and L-AP4) and L-serine-O-phosphate (L-SOP) in cultured cerebellar granule cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9175765&form=6&db=m Two isoforms of prostaglandin EP3 receptor exhibiting constitutive activity and agonist-dependent activity in Rho-mediated stress fiber formation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9176050&form=6&db=m Synergistic increase in Ca2+ produced by A1 adenosine and muscarinic receptor activation via a pertussis-toxin-sensitive pathway in epithelial cells of the rabbit ciliary body. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9176139&form=6&db=m ET-1 cooperates with EGF to induce mitogenesis via a PTX-sensitive pathway in airway smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9176149&form=6&db=m Submandibular enzymatic vasoconstrictor increases DNA and phosphoinositol synthesis by mesenchymal cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9176174&form=6&db=m Involvement of MAP kinase and c-fos signaling in the inhibition of cell growth by somatostatin. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9176188&form=6&db=m Coupling of oxytocin receptor to G proteins in rat myometrium during labor: Gi receptor interaction. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9176218&form=6&db=m Characterization of sphingosine 1-phosphate-induced actions and its signaling pathways in rat hepatocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9176240&form=6&db=m Epidermal growth factor activates phospholipase C-gamma 1 via G(i)1-2 proteins in isolated pancreatic acinar membranes. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9177200&form=6&db=m Insulin-like growth factor II signaling through the insulin-like growth factor II/mannose-6-phosphate receptor promotes exocytosis in insulin-secreting cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9178188&form=6&db=m Effects of ATP on phosphoinositide hydrolysis and prostaglandin E2 generation in rabbit astrocytes. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9178746&form=6&db=m Somatostatin acts by inhibiting the cyclic 3',5'-adenosine monophosphate (cAMP)/protein kinase A pathway, cAMP response element-binding protein (CREB) phosphorylation, and CREB transcription potency. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9178908&form=6&db=m Bombesin and neuromedin B stimulate the activation of p42(mapk) and p74(raf-1) via a protein kinase C-independent pathway in Rat-1 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9179386&form=6&db=m Specific Gq protein involvement in muscarinic M3 receptor-induced phosphatidylinositol hydrolysis and Ca2+ release in mouse duodenal myocytes. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9179622&form=6&db=m Mast cell adenosine induced calcium mobilization via Gi3 and Gq proteins. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9179862&form=6&db=m Luteinizing hormone-releasing hormone (LHRH) attenuates morphine-induced inhibition of cyclic AMP (cAMP) in opioid-responsive SK-N-SH cells. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9180892&form=6&db=m Insulin stimulation of Na/H antiport in L-6 cells: a different mechanism in myoblasts and myotubes. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9184087&form=6&db=m 2-chloroadenosine stimulates granule exocytosis from mouse natural killer cells: evidence for signal transduction through a novel extracellular receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9184811&form=6&db=m Defibrotide augments the anticandidial activity of NK cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9187223&form=6&db=m Towards better pertussis vaccines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9187273&form=6&db=m Somatostatin5 receptor-mediated [35S]guanosine-5'-O-(3-thio)triphosphate binding: agonist potencies and the influence of sodium chloride on intrinsic activity. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9187329&form=6&db=m Galparan induces in vivo acetylcholine release in the frontal cortex. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9188773&form=6&db=m Receptor-mediated modulation of recombinant neuronal class E calcium channels. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9190561&form=6&db=m (R)-methanandamide inhibits receptor-induced calcium responses by depleting internal calcium stores in cultured astrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9190835&form=6&db=m Differences in platelet-activating factor receptor mediated Ca++ response between hamster and guinea pig alveolar macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9191472&form=6&db=m Effect of IL-1 beta on responses of cultured human airway smooth muscle cells to bronchodilator agonists. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9192738&form=6&db=m Potentiation of chemotactic peptide-induced superoxide generation by CD38 ligation in human myeloid cell lines. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9192781&form=6&db=m Pertussis toxin shows distinct early signalling events in platelet-activating factor-, leukotriene B4-, and C5a-induced eosinophil homotypic aggregation in vitro and recruitment in vivo. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9192782&form=6&db=m Plasmin is a potent and specific chemoattractant for human peripheral monocytes acting via a cyclic guanosine monophosphate-dependent pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9193638&form=6&db=m ADP-ribosylation and early transcription regulation by bacteriophage T4. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9193639&form=6&db=m Pertussis toxin. Entry into cells and enzymatic activity. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9193640&form=6&db=m Membrane anchored synthetic peptides as a tool for structure-function analysis of pertussis toxin and its target proteins. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9193642&form=6&db=m Sequence and structural links between distant ADP-ribosyltransferase families. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9194575&form=6&db=m The thrombin receptor in adrenal medullary microvascular endothelial cells is negatively coupled to adenylyl cyclase through a Gi protein. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9195955&form=6&db=m Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. Integration of stimulatory and inhibitory input to the effector adenylyl cyclase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9196056&form=6&db=m Evidence for a dual control of macroautophagic sequestration and intracellular trafficking of N-linked glycoproteins by the trimeric G(i3) protein in HT-29 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9196070&form=6&db=m Somatostatin inhibits interleukin 6 release from rat cortical type I astrocytes via the inhibition of adenylyl cyclase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9196209&form=6&db=m Simple, speedy, sensitive, and specific serodiagnosis of pertussis by using a particle agglutination test. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9199185&form=6&db=m Non-genomic mechanisms of glucocorticoid inhibition of adrenocorticotropin secretion: possible involvement of GTP-binding protein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9200491&form=6&db=m Triggers of autoimmune disease in a murine TCR-transgenic model for multiple sclerosis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9200648&form=6&db=m Glucose stimulates islet beta-cell mitogenesis through GTP-binding proteins and by protein kinase C-dependent mechanisms. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9201690&form=6&db=m Transient Ca2+ changes in endothelial cells induced by low doses of reactive oxygen species: role of hydrogen peroxide. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9202225&form=6&db=m Proliferin induces endothelial cell chemotaxis through a G protein-coupled, mitogen-activated protein kinase-dependent pathway. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9202317&form=6&db=m Amyloid beta protein (25-35) stimulation of phospholipase C in LA-N-2 cells. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9204866&form=6&db=m Pertussis toxin: transition state analysis for ADP-ribosylation of G-protein peptide alphai3C20. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9204917&form=6&db=m Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9207004&form=6&db=m Polarization of chemokine receptors to the leading edge during lymphocyte chemotaxis. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9207005&form=6&db=m Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9207008&form=6&db=m HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9207219&form=6&db=m Fluoroaluminate induces pertussis toxin-sensitive protein phosphorylation: differences in MC3T3-E1 osteoblastic and NIH3T3 fibroblastic cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9208129&form=6&db=m The stimulation of human neutrophil migration by angiotensin IL: its dependence on Ca2+ and the involvement of cyclic GMP. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9208135&form=6&db=m Endothelin receptors and their cellular signal transduction mechanism in human cultured prostatic smooth muscle cells. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9208141&form=6&db=m Evidence that antipsychotic drugs are inverse agonists at D2 dopamine receptors. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9208286&form=6&db=m Selective antagonism of the AT1 receptor inhibits the effect of angiotensin II on DNA and protein synthesis of rat proximal tubular cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9209084&form=6&db=m Activation of porcine oocytes via an exogenously introduced rat muscarinic M1 receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9209506&form=6&db=m The C terminus of the human C5a receptor (CD88) is required for normal ligand-dependent receptor internalization. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9210021&form=6&db=m Pertussis toxin induces lymphocytosis in rhesus macaques. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9210170&form=6&db=m High affinity binding of 125I-neurotensin to dispersed cells from chicken liver and brain. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9211321&form=6&db=m Use of biotinylated NAD to label and purify ADP-ribosylated proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9211357&form=6&db=m Opposite paracrine effects of 5-HT and dopamine on Na(+)-Pi cotransport in opossum kidney cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9211721&form=6&db=m Differential effect of high extracellular Ca2+ on K+ and Cl- conductances in murine osteoclasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9211988&form=6&db=m Identification and characterization of P2Y2 nucleotide receptors in human retinal pigment epithelial cells. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9212055&form=6&db=m Novel isoforms of Mel1c melatonin receptors modulating intracellular cyclic guanosine 3',5'-monophosphate levels. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9213209&form=6&db=m Prejunctional neuropeptide Y receptors in human kidney and atrium. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9213268&form=6&db=m Phototransduction cascade and circadian oscillator in chicken pineal gland. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9213428&form=6&db=m ATP- and EGF-stimulated phosphatidulinositol synthesis by two different pathways, phospholipase D and diacylglycerol kinase, in A-431 epidermoid carcinoma cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9214448&form=6&db=m Enhanced G-protein-induced relaxation in portal hypertensive rats: role of nitric oxide. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9214627&form=6&db=m Gi-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor Shc. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9218610&form=6&db=m Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9218770&form=6&db=m Genetic analysis of pertussis toxin promoter activation in Bordetella pertussis. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9218785&form=6&db=m Aerolysin and pertussis toxin share a common receptor-binding domain. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9222558&form=6&db=m Involvement of calyculin A inhibitable protein phosphatases in the cyclic AMP signal transduction pathway of mouse corticotroph tumour (AtT20) cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9223076&form=6&db=m Endogenous opioid receptor-like receptor in human neuroblastoma SK-N-SH cells: activation of inhibitory G protein and homologous desensitization. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9223288&form=6&db=m Targeted inactivation of alphai2 or alphai3 disrupts activation of the cardiac muscarinic K+ channel, IK+Ach, in intact cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9223384&form=6&db=m N6-isopentenyladenosine affects cAMP-dependent microfilament organization in FRTL-5 thyroid cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9223547&form=6&db=m Signal transduction mechanism(s) involved in prostacyclin production elicited by acetylcholine in coronary endothelial cells of rabbit heart. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9223561&form=6&db=m Activation of alpha-2 adrenergic receptors inhibits norepinephrine release by a pertussis toxin-insensitive pathway independent of changes in cytosolic calcium in cultured rat sympathetic neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9223581&form=6&db=m Adenosine 3',5'-cyclic monophosphate-stimulated Ca++ efflux and acetylcholine release in ileal myenteric plexus are mediated by N-type Ca++ channels: inhibition by the kappa opioid receptor agonist. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9223629&form=6&db=m The pituitary adenylate cyclase activating polypeptide (PACAP I) and VIP (PACAP II VIP1) receptors stimulate inositol phosphate synthesis in transfected CHO cells through interaction with different G proteins. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9224649&form=6&db=m Mitogenic signalling by delta opioid receptors expressed in rat-1 fibroblasts involves activation of the p70s6k/p85s6k S6 kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9224810&form=6&db=m Role of amino- and carboxyl-terminal regions of G(alphaZ) in the recognition of Gi-coupled receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9224819&form=6&db=m The mu-opioid receptor down-regulates differently from the delta-opioid receptor: requirement of a high affinity receptor/G protein complex formation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9225728&form=6&db=m Melatonin receptors are present in adult rat Leydig cells and are coupled through a pertussis toxin-sensitive G-protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9226299&form=6&db=m G proteins and endothelium-dependent relaxations. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9226418&form=6&db=m Corticotropin-releasing factor-like peptides increase cytosolic [Ca2+] in human epidermoid A-431 cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9227281&form=6&db=m Synergistic rise in Ca2+ produced by somatostatin and acetylcholine in ciliary body epithelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9227450&form=6&db=m Adenylyl cyclase inhibitory pathway is differentially modified in rat white and brown fat by high-energy diets. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9227474&form=6&db=m Characterization of PACAP receptors and signaling pathways in rabbit gastric muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9228036&form=6&db=m Both overlapping and distinct signaling pathways for somatostatin receptor subtypes SSTR1 and SSTR2 in pituitary cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9228183&form=6&db=m Purinoceptor-stimulated phosphoinositide hydrolysis in Madin-Darby canine kidney (MDCK) cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9230105&form=6&db=m Co-operation of phosphatidylinositol transfer protein with phosphoinositide 3-kinase gamma in the formylmethionyl-leucylphenylalanine-dependent production of phosphatidylinositol 3,4,5-trisphosphate in human neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9230127&form=6&db=m Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase. causal interaction,diagnostic usage,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9231737&form=6&db=m Cross talk between substance P and melittin-activated cellular signaling pathways in rat lactotroph-enriched cell cultures. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9231756&form=6&db=m Role of mitogen-activated protein kinase pathway in prostaglandin F2alpha-induced rat puerperal uterine contraction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9231761&form=6&db=m Endothelin activates large-conductance K+ channels in rat lactotrophs: reversal by long-term exposure to dopamine agonist. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9231772&form=6&db=m Pituitary adenylate cyclase activating polypeptide stimulates rat Leydig cell steroidogenesis through a novel transduction pathway. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9231782&form=6&db=m Galparan: a powerful insulin-releasing chimeric peptide acting at a novel site. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9234783&form=6&db=m Coexistence of CD14-dependent and independent pathways for stimulation of human monocytes by gram-positive bacteria. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9235901&form=6&db=m Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9235999&form=6&db=m G-protein-mediated signaling in cholesterol-enriched arterial smooth muscle cells. 2. Role of protein kinase C-delta in the regulation of eicosanoid production. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9237867&form=6&db=m Endothelin-1 stimulates the release of arachidonic acid and prostaglandins in cultured human ciliary muscle cells: activation of phospholipase A2. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9240464&form=6&db=m Signaling mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of tyrosine phosphorylation. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9241447&form=6&db=m Effect of pertussis toxin injected into the ventral tegmental area on amphetamine-induced Fos protein in the nucleus accumbens. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9242182&form=6&db=m Endothelin-1 inhibits the slow component of cardiac delayed rectifier K+ currents via a pertussis toxin-sensitive mechanism. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9243514&form=6&db=m Second-messenger regulation of receptor association with clathrin-coated pits: a novel and selective mechanism in the control of CD4 endocytosis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9243640&form=6&db=m Role of Gq alpha in insulin-stimulated glucose uptake by C6 glioma cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9244176&form=6&db=m Mastoparan elicits prostaglandin E2 generation and inhibits inositol phosphate accumulation via different mechanisms in rabbit astrocytes. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9245701&form=6&db=m Modulation of protein kinase C and cAMP-dependent protein kinase by delta-opioid. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9246605&form=6&db=m Post-receptor signal transduction and regulation of 14(R),15(S)-epoxyeicosatrienoic acid (14,15-EET) binding in U-937 cells. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9247061&form=6&db=m Thrombin receptor on rat primary hippocampal neurons: coupled calcium and cAMP responses. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9247266&form=6&db=m Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9247313&form=6&db=m The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9247485&form=6&db=m Tumor necrosis factor alpha inhibits collagen alpha 1(I) gene expression in rat hepatic stellate cells through a G protein. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9249258&form=6&db=m Pharmacological characterization of type 1alpha metabotropic glutamate receptor-stimulated [35S]-GTPgammaS binding. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9249482&form=6&db=m Negative chronotropic and inotropic effects of endothelin isopeptides in mammalian cardiac muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9250360&form=6&db=m Visualization of muscarinic cholinergic receptors on chick cardiomyocytes and their involvement in phosphatidylcholine hydrolysis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9251760&form=6&db=m Improved purification of transducin subunits from bovine retinal rod outer segments. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9252137&form=6&db=m Possible involvement of pertussis toxin-sensitive G protein in hepatocyte growth factor-induced signal transduction in cultured rat hepatocytes: pertussis toxin treatment inhibits activation of phospholipid signaling, calcium oscillation, and mitogen-activated protein kinase. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9252534&form=6&db=m Lysophosphatidic acid and EGF stimulate mitogenesis in human airway smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9253651&form=6&db=m Identifying the G protein, Gz alpha, and its associated proteins in nervous tissue using mass spectrometry and microsequencing techniques. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9254664&form=6&db=m Murine astrocytes express a functional chemokine receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9256158&form=6&db=m Protein tyrosine kinase involvement in the production of superoxide anion by neutrophils exposed to Aroclor 1242, a mixture of polychlorinated biphenyls. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9257265&form=6&db=m Quantification of cell-associated and free antigens in Bordetella pertussis suspensions by antigen binding ELISA. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9259013&form=6&db=m 5-HT1A agonists induce central cholinergic antinociception. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9261135&form=6&db=m Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9261144&form=6&db=m Differential coupling of muscarinic m2 and m3 receptors to adenylyl cyclases V/VI in smooth muscle. Concurrent M2-mediated inhibition via Galphai3 and m3-mediated stimulation via Gbetagammaq. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9261943&form=6&db=m Expression of a synthetic pertussis toxin operon in Escherichia coli. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9262181&form=6&db=m G-proteins are involved in riluzole inhibition of high voltage-activated calcium channels in rat dorsal root ganglion neurons. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9262330&form=6&db=m Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9263913&form=6&db=m Receptors couple to L-type calcium channels via distinct Go proteins in rat neuroendocrine cell lines. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9263916&form=6&db=m Calcium release from intracellular stores evoked by extracellular ATP in a Xenopus renal epithelial cell line. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9266094&form=6&db=m Guanosine 5'-O-(3-thiotriphosphate) and cations regulate melatonin receptors, and melatonin inhibits cyclic AMP production in the spinal cord. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9267411&form=6&db=m Pneumocystis carinii infection alters GTP-binding proteins in the lung. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9268166&form=6&db=m HIV-1 coreceptor activity of CCR5 and its inhibition by chemokines: independence from G protein signaling and importance of coreceptor downmodulation. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9269539&form=6&db=m Histamine-stimulated phospholipase C signalling in the adrenal chromaffin cell: effects on inositol phospholipid metabolism and tyrosine hydroxylase phosphorylation. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9269541&form=6&db=m G(o)2 and Gi3 proteins mediate the action of somatostatin on membrane Ca2+ and K+ currents in ovine pituitary somatotrophs. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9269943&form=6&db=m Differential signaling pathways in platelet-activating factor-induced proliferation and interleukin-6 production by rat vascular smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9270372&form=6&db=m Relaxation of evoked contractile activity of isolated guinea-pig ileum by (+/-)-kavain. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9271155&form=6&db=m Functional uncoupling between the receptor and G-protein as the result of PKC activation, observed in Aplysia neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9271339&form=6&db=m Activation of type II adenylate cyclase by D2 and D4 but not D3 dopamine receptors. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9271344&form=6&db=m 5-hydroxytryptamine1A receptor-mediated increases in receptor expression and activation of nuclear factor-kappaB in transfected Chinese hamster ovary cells. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9271361&form=6&db=m Interferon-inducible protein-10 and lymphotactin induce the chemotaxis and mobilization of intracellular calcium in natural killer cells through pertussis toxin-sensitive and -insensitive heterotrimeric G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9271492&form=6&db=m A cysteine-3 to serine mutation of the G-protein Gi1 alpha abrogates functional activation by the alpha 2A-adrenoceptor but not interactions with the beta gamma complex. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9271506&form=6&db=m Sphingosine 1-phosphate regulates melanoma cell motility through a receptor-coupled extracellular action and in a pertussis toxin-insensitive manner. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9271589&form=6&db=m Identification of human neutrophil-derived cathepsin G and azurocidin/CAP37 as chemoattractants for mononuclear cells and neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9272340&form=6&db=m Adverse reactions of a pertussis toxoid vaccine in a double-blind placebo-controlled trial. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9272353&form=6&db=m Serological responses to infection with B. pertussis. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9272365&form=6&db=m Acellular vaccines induce cell-mediated immunity to Bordetella pertussis antigens in infants undergoing primary vaccination against pertussis. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9272729&form=6&db=m Alpha2-adrenoceptors in opossum kidney cells couple to stimulation of mitogen-activated protein kinase independently of adenylyl cyclase inhibition. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9272731&form=6&db=m Mechanisms of serotonin-induced Ca2+ responses in mesangial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9273995&form=6&db=m Quartz crystal microbalance investigation of the interaction of bacterial toxins with ganglioside containing solid supported membranes. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9274627&form=6&db=m Intracellular signalling by binding sites for the antipsoriatic agent monomethylfumarate on human granulocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9275041&form=6&db=m Stimulation of cell proliferation by calcium and a calcimimetic compound. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9276777&form=6&db=m Inhibitory effects of glibenclamide and pertussis toxin on the attenuation of ischemia-induced myocardial acidosis following ischemic preconditioning in dogs. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9277348&form=6&db=m Muscarinic signaling pathway for calcium release and calcium-activated chloride current in smooth muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9277358&form=6&db=m Cholinergic modulation of the Ca2+ response to bradykinin in neuroblastoma cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9277376&form=6&db=m Effects of triiodothyronine administration on the adenylyl cyclase system in brown adipose tissue of rat. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9277420&form=6&db=m Motilin and OHM-11526 activate a calcium current in human and canine jejunal circular smooth muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9278958&form=6&db=m Comparison of sensitization elicited by amphetamine and pertussis toxin: characterization of locomotor behavior and limbic dopamine release. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9279808&form=6&db=m Different G proteins mediate somatostatin-induced inward rectifier K+ currents in murine brain and endocrine cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9281602&form=6&db=m Enhanced type 1alpha metabotropic glutamate receptor-stimulated phosphoinositide signaling after pertussis toxin treatment. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9281604&form=6&db=m Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9281614&form=6&db=m Selective inhibition of adenylyl cyclase type V by the dopamine D3 receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9282930&form=6&db=m Lysophosphatidic acid-induced proliferation-related signals in astrocytes. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9283691&form=6&db=m Evidence that the substance P-induced enhancement of pacemaking in lymphatics of the guinea-pig mesentery occurs through endothelial release of thromboxane A2. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9283705&form=6&db=m Characterization of the signalling pathways involved in ATP and basic fibroblast growth factor-induced astrogliosis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9283706&form=6&db=m Characterization of the Ca2+ responses evoked by ATP and other nucleotides in mammalian brain astrocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9283713&form=6&db=m Involvement of protein kinase C in the UTP-mediated potentiation of cyclic AMP accumulation in mouse J774 macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9283719&form=6&db=m Differential effects of lovastatin on mitogen induced calcium influx in human cultured vascular smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9286047&form=6&db=m Acellular pertussis vaccines containing genetically detoxified pertussis toxin induce long-lasting humoral and cellular responses in adults. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9286049&form=6&db=m Acellular pertussis vaccine in children with perinatal human immunodeficiency virus-type 1 infection. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9287315&form=6&db=m Betagamma subunits of pertussis toxin-sensitive G proteins mediate A1 adenosine receptor agonist-induced activation of phospholipase C in collaboration with thyrotropin. A novel stimulatory mechanism through the cross-talk of two types of receptors. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9287361&form=6&db=m Chemotactic peptide-induced activation of Ras in human neutrophils is associated with inhibition of p120-GAP activity. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9288146&form=6&db=m Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9288674&form=6&db=m Differential effects of endothelin-1 on basal and isoprenaline-enhanced Ca2+ current in guinea-pig ventricular myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9288945&form=6&db=m The biochemical effect of the naturally occurring Trp64-->Arg mutation on human beta3-adrenoceptor activity. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9294129&form=6&db=m Glucose activates the carboxyl methylation of gamma subunits of trimeric GTP-binding proteins in pancreatic beta cells. Modulation in vivo by calcium, GTP, and pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9296526&form=6&db=m Pertussis toxin- and PMA-insensitive calcium mobilization by sphingosine in CFPAC-1 cells: evidence for a phosphatidic acid-dependent mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9298768&form=6&db=m A novel action of collapsin: collapsin-1 increases antero- and retrograde axoplasmic transport independently of growth cone collapse. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9299566&form=6&db=m The heterotrimeric GTP-binding protein, GS, modulates the Cl- conductance of rat parotid acinar secretory granules. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9300719&form=6&db=m Effects of 5-oxo-6,8,11,14-eicosatetraenoic acid on expression of CD11b, actin polymerization, and adherence in human neutrophils. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9303556&form=6&db=m Proadrenomedullin N-terminal 20 peptide (PAMP) inhibits proliferation of human neuroblastoma TGW cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9304336&form=6&db=m [A polyvalent complex of Bordetella pertussis antigens as the basis for an acellular pertussis vaccine] diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9305905&form=6&db=m The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9305927&form=6&db=m Control of the expression and activity of the Galpha-interacting protein (GAIP) in human intestinal cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9307104&form=6&db=m Dopamine inhibition: enhancement of GABA activity and potassium channel activation in hypothalamic and arcuate nucleus neurons. diagnostic usage,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9307110&form=6&db=m Involvement of cAMP-dependent protein kinase in mu-opioid modulation of NMDA-mediated synaptic currents. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9307112&form=6&db=m Modulation of Ca2+ currents by various G protein-coupled receptors in sympathetic neurons of male rat pelvic ganglia. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9310425&form=6&db=m Neurotensin and substance P inhibit low- and high-voltage-activated Ca2+ channels in cultured newborn rat nucleus basalis neurons. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9310437&form=6&db=m Muscarinic receptor activation modulates Ca2+ channels in rat intracardiac neurons via a PTX- and voltage-sensitive pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9312098&form=6&db=m Two basic amino acids in the second inner loop of the interleukin-8 receptor are essential for Galpha16 coupling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9313925&form=6&db=m Selective inhibition of adenylyl cyclase by octopamine via a human cloned alpha 2A-adrenoceptor. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9316499&form=6&db=m Lipoprotein-stimulated surfactant secretion in alveolar type II cells: mediation by heterotrimeric G proteins. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9316506&form=6&db=m IL-1 beta alters beta-adrenergic receptor adenylyl cyclase system function in human airway epithelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9316829&form=6&db=m Mechanism of down-regulation of alpha-2 adrenergic receptor subtypes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9316832&form=6&db=m Mechanisms of bradykinin-induced insulin secretion in clonal beta cell line RINm5F. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9316844&form=6&db=m Differentiation of muscarinic receptors mediating negative chronotropic and vasoconstrictor responses to acetylcholine in isolated rat hearts. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9321846&form=6&db=m Melatonin directly constricts rat cerebral arteries through modulation of potassium channels. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9322797&form=6&db=m Effects of alpha 2-adrenergic agonism, imidazolines, and G-protein on insulin secretion in beta cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9322911&form=6&db=m Sphingosine 1-phosphate mobilizes sequestered calcium, activates calcium entry, and stimulates deoxyribonucleic acid synthesis in thyroid FRTL-5 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9322919&form=6&db=m The human V3 pituitary vasopressin receptor: ligand binding profile and density-dependent signaling pathways. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9324949&form=6&db=m A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9325359&form=6&db=m M4 muscarinic receptor activation modulates calcium channel currents in rat intracardiac neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9326269&form=6&db=m P2Y receptor linked to phospholipase C: stimulation of neuro 2A cells by UTP and ATP and possible regulation by protein kinase C subtype epsilon. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9326357&form=6&db=m Adrenaline inhibits depolarization-induced increases in capacitance the presence of elevated [Ca2+]i in insulin secreting cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9326761&form=6&db=m Prevention of experimental autoimmune uveoretinitis by intrathymic S-antigen injection. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9329970&form=6&db=m Pertussis toxin-sensitive G proteins as mediators of the signal transduction pathways activated by cytomegalovirus infection of smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9329974&form=6&db=m Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9330468&form=6&db=m Immunoglobulin E and G responses to pertussis toxin in children immunised with adsorbed and non-adsorbed whole cell pertussis vaccines. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9330852&form=6&db=m Mobilisation of intracellular calcium by P2Y2 receptors in cultured, non-transformed bovine ciliary epithelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9340578&form=6&db=m [In vitro study of endothelium-dependent relaxation and contraction of human atherosclerotic femoral artery] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9340579&form=6&db=m [Intracellular signal transmission of low density lipoprotein receptors in human monocytes] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9341718&form=6&db=m Extracellular nucleotide-induced [Ca2+]i elevation in rat basilar smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9341775&form=6&db=m Blood- and skin-derived monocytes/macrophages respond to C3a but not to C3a(desArg) with a transient release of calcium via a pertussis toxin-sensitive signal transduction pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9342388&form=6&db=m Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9342733&form=6&db=m Opioid receptor and calcium channel regulation of adenylyl cyclase, modulated by GM1, in NG108-15 cells: competitive interactions. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9345263&form=6&db=m Platelet-activating factor stimulates calcium-dependent activation of protein-tyrosine kinase Syk in a human B cell line. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9346964&form=6&db=m G-Protein-coupled receptors and Fcgamma-receptors mediate activation of Akt/protein kinase B in human phagocytes. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9346976&form=6&db=m A safety and immunogenicity comparison of 12 acellular pertussis vaccines and one whole-cell pertussis vaccine given as a fourth dose in 15- to 20-month-old children. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9348200&form=6&db=m Studies of melatonin effects on epithelia using the human embryonic kidney-293 (HEK-293) cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9348283&form=6&db=m Homotypic lysosome fusion in macrophages: analysis using an in vitro assay. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9349414&form=6&db=m T cell mechanisms in experimental autoimmune uveoretinitis: susceptibility is a function of the cytokine response profile. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9349557&form=6&db=m Regulation of spontaneous activity of the delta-opioid receptor: studies of inverse agonism in intact cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9349561&form=6&db=m Modulation of GH4 cell cycle via A1 adenosine receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9349657&form=6&db=m Inhibition of M-type K+ and N-type Ca2+ channels by the human gonadotropin-releasing-hormone receptor heterologously expressed in adult neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9351387&form=6&db=m Involvement of calcium and G proteins in the acute release of tissue-type plasminogen activator and von Willebrand factor from cultured human endothelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9351437&form=6&db=m Evidence that angiotensin II and lipoxygenase products activate c-Jun NH2-terminal kinase. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9351501&form=6&db=m Noradrenaline release from rat sympathetic neurones triggered by activation of B2 bradykinin receptors. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9351890&form=6&db=m G-protein regulation of an L-type calcium channel current in canine jejunal circular smooth muscle. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9351976&form=6&db=m Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9351981&form=6&db=m Down-regulation of mu-opioid receptor by full but not partial agonists is independent of G protein coupling. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9352881&form=6&db=m Epidermal growth factor inhibits bombesin-induced activation of phospholipase C-beta1 in rat pancreatic acinar cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9353055&form=6&db=m Differences in coughing and other responses to intrabronchial infection with Bordetella pertussis among strains of rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9353321&form=6&db=m Tissue factor is induced by monocyte chemoattractant protein-1 in human aortic smooth muscle and THP-1 cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9353363&form=6&db=m Opioid efficacy in a C6 glioma cell line stably expressing the delta opioid receptor. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9353382&form=6&db=m Pharmacological characterization of the "silent" 5-hydroxytryptamine1B-like receptors of rabbit ear artery. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9353595&form=6&db=m Molecular mechanisms underlying forskolin-mediated up-regulation of human dopamine D2L receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9354968&form=6&db=m IFN-gamma-mediated protection against intracerebral challenge with Bordetella pertussis in mice. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9355746&form=6&db=m Novel bradykinin signalling events in PC-12 cells: stimulation of the cAMP pathway leads to cAMP-mediated translocation of protein kinase Cepsilon. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9357760&form=6&db=m Ca2+-sensing receptors in intestinal epithelium. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9357768&form=6&db=m Regulation of vascular angiotensin II receptors by EGF. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9357777&form=6&db=m ANG II AT1 and AT2 receptors both inhibit bFGF-induced proliferation of bovine adrenocortical cells. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9357832&form=6&db=m Molecular mechanisms for the growth factor action of gastrin. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9359460&form=6&db=m Etorphine inhibits cell growth and induces apoptosis in SK-N-SH cells: involvement of pertussis toxin-sensitive G proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9359588&form=6&db=m Mu and delta opioids but not kappa opioid inhibit voltage-activated Ba2+ currents in neuronal F-11 cell. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9359846&form=6&db=m Role of G-protein beta gamma subunits in the augmentation of P2Y2 (P2U)receptor-stimulated responses by neuropeptide Y Y1 Gi/o-coupled receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9359874&form=6&db=m Guidance of CNS growth cones by substratum grooves and ridges: effects of inhibitors of the cytoskeleton, calcium channels and signal transduction pathways. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9359881&form=6&db=m A heterotrimeric G protein-phospholipase A2 signaling cascade is involved in the regulation of peroxisomal motility in CHO cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9359901&form=6&db=m Ca2+-channel-dependent and -independent inhibition of exocytosis by extracellular ATP in voltage-clamped rat adrenal chromaffin cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9362229&form=6&db=m Role of beta1- and beta2-adrenergic receptors in regulation of Cl- and Ca2+ channels in guinea pig ventricular myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9362238&form=6&db=m Autoreceptor-induced inhibition of neuropeptide Y release from PC-12 cells is mediated by Y2 receptors. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9362302&form=6&db=m A1 adenosine receptors potently regulate heart rate in mammalian embryos. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9364476&form=6&db=m G protein coupling of the rat A1-adenosine receptor--partial purification of a protein which stabilizes the receptor-G protein association. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9364700&form=6&db=m Feasibility study of a combined diphtheria-tetanus-acellular pertussis-hepatitis B (DTPa-HBV) vaccine, and comparison of clinical reactions and immune responses with diphtheria-tetanus-acellular pertussis (DTPa) and hepatitis B vaccines applied as mixed or injected into separate limbs. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9365016&form=6&db=m Delta9-tetrahydrocannabinol stimulates glucose utilization in C6 glioma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9365121&form=6&db=m Eotaxin influences the development of embryonic hematopoietic progenitors in the mouse. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9365908&form=6&db=m Muscarinic Ca2+ responses resistant to muscarinic antagonists at perisynaptic Schwann cells of the frog neuromuscular junction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9367876&form=6&db=m The monocyte chemotactic protein-4 induces oxygen radical production, actin reorganization, and CD11b up-regulation via a pertussis toxin-sensitive G-protein in human eosinophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9369247&form=6&db=m A newly identified peptide, proadrenomedullin N-terminal 20 peptide, induces hypotensive action via pertussis toxin-sensitive mechanisms. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9369266&form=6&db=m Insulin enhances endothelial alpha2-adrenergic vasorelaxation by a pertussis toxin mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9371425&form=6&db=m Effect of adenosine on the ouabain-insensitive Na+-ATPase activity from basolateral membrane of the proximal tubule. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9371546&form=6&db=m Alpha2-adrenoceptor regulation of adenylyl cyclase in CHO cells: dependence on receptor density, receptor subtype and current activity of adenylyl cyclase. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9371707&form=6&db=m Mechanisms of mitogen-activated protein kinase activation by nicotine in small-cell lung carcinoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9371715&form=6&db=m A newly synthesized molecule derived from ruthenium cation, with antitumour activity, activates NADPH oxidase in human neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9374654&form=6&db=m The mineralocorticoid aldosterone activates a proton conductance in cultured kidney cells. causal interaction,ongoing research,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9375962&form=6&db=m Somatostatin sst5 inhibition of receptor mediated regeneration of rat aortic vascular smooth muscle cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9376223&form=6&db=m Agonist-mediated tyrosine phosphorylation of isoforms of the shc adapter protein by the delta opioid receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9376224&form=6&db=m Sodium saccharin inhibits adenylyl cyclase activity in non-taste cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9378500&form=6&db=m An immunosuppressive agent, FTY720, increases intracellular concentration of calcium ion and induces apoptosis in HL-60. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9378964&form=6&db=m Signal transduction for melatonin in human lymphocytes: involvement of a pertussis toxin-sensitive G protein. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9382767&form=6&db=m Bacterial ADP-ribosylating toxins: form, function, and recombinant vaccine development. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9382922&form=6&db=m Cloning and functional characterization of the mouse C3a anaphylatoxin receptor gene. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9382943&form=6&db=m Dual modulation of calcium channel current via recombinant alpha2-adrenoceptors in pheochromocytoma (PC-12) cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9386185&form=6&db=m Functional compartmentalization of ATP is involved in angiotensin II-mediated closure of cardiac ATP-sensitive K+ channels. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9388473&form=6&db=m Nociceptin/orphanin FQ activates protein kinase C, and this effect is mediated through phospholipase C/Ca2+ pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9388493&form=6&db=m Prosaposin receptor: evidence for a G-protein-associated receptor. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9389482&form=6&db=m Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9393726&form=6&db=m Essential role of the consensus nucleotide-binding site of PtlH in secretion of pertussis toxin from Bordetella pertussis. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9395335&form=6&db=m Inhibitory guanine-nucleotide-binding-regulatory protein alpha subunits in medaka (Oryzias latipes) oocytes--cDNA cloning and decreased expression of proteins during oocyte maturation. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9395453&form=6&db=m Muscarinic receptor-mediated dual regulation of ADP-ribosyl cyclase in NG108-15 neuronal cell membranes. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9395492&form=6&db=m Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9395506&form=6&db=m G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9397950&form=6&db=m A comparative study of the role of adenylate cyclase in the release of adrenocorticotropin from the ovine and rat anterior pituitary. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9399104&form=6&db=m Mechanisms involved in activation of human eosinophil exocytosis by substance P: an in vitro model of sensory neuroimmunomodulation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9400003&form=6&db=m Delta opioid modulation of the binding of guanosine-5'-O-(3-[35S]thio)triphosphate to NG108-15 cell membranes: characterization of agonist and inverse agonist effects. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9401738&form=6&db=m Mastoparan-induced apoptosis of cultured cerebellar granule neurons is initiated by calcium release from intracellular stores. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9402365&form=6&db=m Evaluation of pertussis in U.S. Marine Corps trainees. diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9404952&form=6&db=m Peripheral non-opioid analgesic effects of kyotorphin in mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9405282&form=6&db=m Differential routes of Ca2+ influx in Swiss 3T3 fibroblasts in response to receptor stimulation. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9405357&form=6&db=m A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9406659&form=6&db=m Volume-activated taurine transport is differentially activated in human cervical cancer HT-3 cells but not in human papillomavirus-immortalized Z183A and normal cervical epithelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9406926&form=6&db=m Lysophosphatidic acid potentiates ACh receptor currents by G-protein-mediated activation of protein kinase C. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9409288&form=6&db=m Two intracellular signaling pathways for activation of protein kinase C are involved in oxidized low-density lipoprotein-induced macrophage growth. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9413553&form=6&db=m Endogenous trypsin receptors in Xenopus oocytes: linkage to internal calcium stores. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9415407&form=6&db=m Extracellular signal-regulated kinase-1 and -2 respond differently to mitogenic and differentiative signaling pathways in myoblasts. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9415712&form=6&db=m Neuropeptide Y inhibits chromaffin cell nicotinic receptor-stimulated tyrosine hydroxylase activity through a receptor-linked G protein-mediated process. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9415716&form=6&db=m Role of G alpha q or G alpha o proteins in alpha 1-adrenoceptor subtype-mediated responses in Fischer 344 rat aorta. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9417122&form=6&db=m Secretory phospholipase A2 activates the cascade of mitogen-activated protein kinases and cytosolic phospholipase A2 in the human astrocytoma cell line 1321N1. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9417139&form=6&db=m Nitric oxide signaling mediates stimulation of L-type Ca2+ current elicited by withdrawal of acetylcholine in cat atrial myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9419434&form=6&db=m Initiation and regulation of CNS autoimmunity. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9421167&form=6&db=m Substance P modulates sensory action potentials in the lamprey via a protein kinase C-mediated reduction of a 4-aminopyridine-sensitive potassium conductance. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9421230&form=6&db=m Mechanism of the mitogenic effect of fluoride on osteoblast-like cells: evidences for a G protein-dependent tyrosine phosphorylation process. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9421279&form=6&db=m Influence of flupirtine on a G-protein coupled inwardly rectifying potassium current in hippocampal neurones. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9421413&form=6&db=m Activation of calcium-permeable cation channel by insulin in Chinese hamster ovary cells expressing human insulin receptors. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9422801&form=6&db=m A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9425010&form=6&db=m Angiotensin II type 2 receptor stimulation of neuronal delayed-rectifier potassium current involves phospholipase A2 and arachidonic acid. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9425207&form=6&db=m Rat group I metabotropic glutamate receptors inhibit neuronal Ca2+ channels via multiple signal transduction pathways in HEK 293 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9425268&form=6&db=m Unsaturated fatty acids mobilize intracellular calcium independent of IP3 generation and VIA insertion at the plasma membrane. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9425295&form=6&db=m Enhancement by baclofen of the Gs-coupled receptor-mediated cAMP production in Xenopus oocytes expressing rat brain cortex poly (A)+ RNA: a role of G-protein beta gamma subunits. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9426237&form=6&db=m Measurement of agonist efficacy using an alpha2A-adrenoceptor-Gi1alpha fusion protein. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9427051&form=6&db=m Serum antibodies to diphtheria-tetanus-pertussis vaccine components in Argentine children. diagnostic usage,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9427455&form=6&db=m Safety and immunogenicity of a combined pentavalent diphtheria, tetanus, acellular pertussis, inactivated poliovirus and Haemophilus influenzae type b-tetanus conjugate vaccine in infants, compared with a whole cell pertussis pentavalent vaccine. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9428812&form=6&db=m Lysophosphatidic acid stimulates phospholipase D activity and cell proliferation in PC-3 human prostate cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9430632&form=6&db=m The heterotrimeric G protein Go2 regulates catecholamine uptake by secretory vesicles. diagnostic usage,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9432978&form=6&db=m Molecular mechanisms of lymphocyte homing to peripheral lymph nodes. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9434131&form=6&db=m Functional characterization and mRNA expression of pituitary adenylate cyclase activating polypeptide (PACAP) type I receptors in rat peritoneal macrophages. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9434781&form=6&db=m Midkine, a retinoic acid-inducible heparin-binding cytokine, is a novel regulator of intracellular calcium in human neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9435187&form=6&db=m Contractile roles of the M2 and M3 muscarinic receptors in the guinea pig colon. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9435190&form=6&db=m LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9435453&form=6&db=m Nongenomic effects of androstenedione on human granulosa luteinizing cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9436816&form=6&db=m P2 purinoceptors in cultured bovine middle cerebral artery endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9437736&form=6&db=m Gastrin induces IP3 formation through phospholipase C gamma 1 and pp60c-src kinase. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9438382&form=6&db=m G proteins and regulation of pyruvate dehydrogenase activity by insulin in human circulating lymphocytes. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9439624&form=6&db=m G protein coupled receptor signaled apoptosis is associated with activation of a cation insensitive acidic endonuclease and intracellular acidification. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9440086&form=6&db=m Nonbiocompatible hemodialysis membranes induce apoptosis in mononuclear cells: the role of G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9442068&form=6&db=m Sensitization of the histamine H1 receptor by increased ligand affinity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9444526&form=6&db=m Pharmacological characterization of the contractile effects of galanin (1-29)-NH2, galantide and galanin (1-14)-(alpha-aminobutyric acid8)scyliorhinin-I in the rat gastric fundus. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9446569&form=6&db=m Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9447865&form=6&db=m Sensitization of the cardiac Na channel to alpha1-adrenergic stimulation by inhalation anesthetics: evidence for distinct modulatory pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9449618&form=6&db=m Ranakinin, a naturally occurring tachykinin, stimulates phospholipase C activity in the frog adrenal gland. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9453311&form=6&db=m Lysophosphatidylcholine stimulates MAP kinase activity in rat vascular smooth muscle cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9453463&form=6&db=m Identification of G protein-coupled receptors potently stimulating migration of human transitional-cell carcinoma cells. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9453557&form=6&db=m Opioid modulation of extracellular signal-regulated protein kinase activity is ras-dependent and involves Gbetagamma subunits. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9453561&form=6&db=m Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9453625&form=6&db=m Polymorphism in the Bordetella pertussis virulence factors P.69/pertactin and pertussis toxin in The Netherlands: temporal trends and evidence for vaccine-driven evolution. causal interaction,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9454807&form=6&db=m Regulation of K+ and Ca++ channels by a family of neuropeptide Y receptors. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9457477&form=6&db=m Nitric oxide and cyclic nucleotides participate in the relaxation of diclofenac on rat uterine smooth muscle. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458196&form=6&db=m Biochemical investigation of cell motile activity in rheumatoid synovial fluid. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458715&form=6&db=m Suppression of cAMP by phosphoinositol/Ca2+ pathway in the cardiac kappa-opioid receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9459308&form=6&db=m Functional expression of the murine D2, D3, and D4 dopamine receptors in Xenopus laevis oocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9462300&form=6&db=m Activation of the prostaglandin FP receptor in human granulosa cells. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9462664&form=6&db=m Pancreastatin receptor is coupled to a guanosine triphosphate-binding protein of the G(q/11)alpha family in rat liver membranes. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9463417&form=6&db=m Adenosine A1 receptors mediate retinotectal presynaptic inhibition: uncoupling by C-kinase and role in LTP during regeneration. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9463438&form=6&db=m Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9463473&form=6&db=m Recombinant human CXC-chemokine receptor-4 in melanophores are linked to Gi protein: seven transmembrane coreceptors for human immunodeficiency virus entry into cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9464820&form=6&db=m Pertussis toxin can replace T cell receptor signals that induce positive selection of CD8 T cells. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9465016&form=6&db=m Presynaptic GABAB autoreceptor modulation of P/Q-type calcium channels and GABA release in rat suprachiasmatic nucleus neurons. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9466815&form=6&db=m Two opposite signal transducing mechanisms regulate a G-protein-coupled guanylyl cyclase. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9467822&form=6&db=m Involvement of tyrosine kinase in capacitative Ca2+ entry pathway in rat glioma C6 cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9468531&form=6&db=m Coexpression of ligand-gated P2X and G protein-coupled P2Y receptors in smooth muscle. Preferential activation of P2Y receptors coupled to phospholipase C (PLC)-beta1 via Galphaq/11 and to PLC-beta3 via Gbetagammai3. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9468534&form=6&db=m Adenosine A1 receptor-mediated modulation of dopamine D1 receptors in stably cotransfected fibroblast cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9469461&form=6&db=m Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9473490&form=6&db=m Insulin-like growth factor II inhibits glucose-induced insulin exocytosis. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9478929&form=6&db=m Leukotriene D4 activates mitogen-activated protein kinase through a protein kinase Calpha-Raf-1-dependent pathway in human monocytic leukemia THP-1 cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9481486&form=6&db=m Differential osmosensing signalling pathways and G-protein involvement in human cervical cells with different tumour potential. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9482792&form=6&db=m Metabotropic glutamate receptors negatively regulate melatonin synthesis in rat pinealocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9483507&form=6&db=m Neuropeptide Y2 receptors on nerve endings from the rat neurohypophysis regulate vasopressin and oxytocin release. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9485193&form=6&db=m Selective suppression of antigen-specific Th2 cells by continuous micro-dose oral tolerance. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9485425&form=6&db=m Transition-state structure for the ADP-ribosylation of recombinant Gialpha1 subunits by pertussis toxin. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9486121&form=6&db=m Cl- currents activated via purinergic receptors in Xenopus follicles. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9486126&form=6&db=m Adenylyl cyclase is involved in desensitization and recovery of ATP-stimulated Cl- secretion in MDCK cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9486181&form=6&db=m Impaired G protein function in gallbladder muscle from progesterone-treated guinea pigs. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9486184&form=6&db=m Mechanism of galanin-induced contraction of longitudinal smooth muscle of the rat jejunum. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9486197&form=6&db=m Significant cholinergic role in secretin-stimulated exocrine secretion in isolated rat pancreas. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9486662&form=6&db=m Cell type-specific angiotensin II-evoked signal transduction pathways: critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9486977&form=6&db=m Native low density lipoprotein-induced calcium transients trigger VCAM-1 and E-selectin expression in cultured human vascular endothelial cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9488826&form=6&db=m Effect of heat inactivation of serum on Bordetella pertussis antibody determination by enzyme-linked immunosorbent assay. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9489755&form=6&db=m Nociceptin/orphanin FQ activates mitogen-activated protein kinase in Chinese hamster ovary cells expressing opioid receptor-like receptor. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9490673&form=6&db=m The chemotactic cytokine eotaxin acts as a granulocyte-macrophage colony-stimulating factor during lung inflammation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9490747&form=6&db=m Heterotrimeric G proteins are implicated in gibberellin induction of a-amylase gene expression in wild oat aleurone unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9490819&form=6&db=m Endomorphins inhibit high-threshold Ca2+ channel currents in rodent NG108-15 cells overexpressing mu-opioid receptors. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9491206&form=6&db=m Gastrin-releasing peptide-induced expression of prostaglandin synthase-2 in Swiss 3T3 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9491507&form=6&db=m Construction and characterisation of Salmonella typhimurium aroA simultaneously expressing the five pertussis toxin subunits. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9492022&form=6&db=m Regulation of cholecystokinin secretion by peptones and peptidomimetic antibiotics in STC-1 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9492299&form=6&db=m GTP-binding protein gamma12 subunit phosphorylation by protein kinase C--identification of the phosphorylation site and factors involved in cultured cells and rat tissues in vivo. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9493566&form=6&db=m Opioid inhibition of adenylyl cyclase in membranes from pertussis toxin-treated NG108-15 cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9494074&form=6&db=m Lysophosphatidic acid-mediated signal-transduction pathways involved in the induction of the early-response genes prostaglandin G/H synthase-2 and Egr-1: a critical role for the mitogen-activated protein kinase p38 and for Rho proteins. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9496347&form=6&db=m Seminal fluid factor increases the resistance of the tight junctional complex of cultured human cervical epithelium CaSki cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9497428&form=6&db=m Activation of presynaptic GABAB receptors inhibits evoked IPSCs in rat magnocellular neurons in vitro. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9498636&form=6&db=m Enhanced G protein activation in IDDM patients with diabetic nephropathy. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9498785&form=6&db=m CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9500666&form=6&db=m Melatonin receptors in the spinal cord. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9501021&form=6&db=m The effect of pertussis toxin on zebrafish development: a possible role for inhibitory G-proteins in hedgehog signaling. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9501252&form=6&db=m Multiple neurological abnormalities in mice deficient in the G protein Go. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9502445&form=6&db=m Prevalence of markers of exposure to Bordetella pertussis among Italian young adults. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9502768&form=6&db=m Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9502785&form=6&db=m Pertussis toxin-sensitive G proteins influence nitric oxide synthase III activity and protein levels in rat heart. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9503335&form=6&db=m Novel mechanism for non-genomic action of 17 beta-oestradiol on kainate-induced currents in isolated rat CA1 hippocampal neurones. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9504380&form=6&db=m Effects of quinapril, losartan and hydralazine on cardiac hypertrophy and beta-adrenergic neuroeffector mechanisms in transgenic (mREN2)27 rats. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9506474&form=6&db=m Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9507029&form=6&db=m Identification of a structural element in phospholipase C beta2 that interacts with G protein betagamma subunits. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9508295&form=6&db=m Evaluation of PCR for diagnosis of Bordetella pertussis and Bordetella parapertussis infections. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9509210&form=6&db=m Mivazerol prevents the tachycardia caused by emergence from halothane anesthesia partly through activation of spinal alpha 2-adrenoceptors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9510009&form=6&db=m Role of endothelin-1 in regulating proliferation of cultured human uterine smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9510086&form=6&db=m Negative inotropic action of alpha-1a adrenoceptor blocking agents: role of adenosine and ATP-sensitive K+ channels. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9512777&form=6&db=m Detection and quantitation of heterotrimeric G proteins by fluorescence resonance energy transfer. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9513047&form=6&db=m Angiotensin II induces diverse signal transduction pathways via both Gq and Gi proteins in liver epithelial cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9515017&form=6&db=m U50,488H inhibits effects of norepinephrine in rat cardiomyocytes-cross-talk between kappa-opioid and beta-adrenergic receptors. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9515109&form=6&db=m [Endothelial dysfunction and atherosclerosis] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9516456&form=6&db=m cAMP stimulates osteoblast-like differentiation of calcifying vascular cells. Potential signaling pathway for vascular calcification. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9517433&form=6&db=m The role of G proteins in the activity and mercury modulation of GABA-induced currents in rat neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9517568&form=6&db=m ATP-induced arachidonic acid release in cultured astrocytes is mediated by Gi protein coupled P2Y1 and P2Y2 receptors. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9519806&form=6&db=m Characterization of a streptococcal antitumor glycoprotein (SAGP). ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9521133&form=6&db=m Evaluation of an immunoglobulin G enzyme-linked immunosorbent assay for pertussis toxin and filamentous hemagglutinin in diagnosis of pertussis in Senegal. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9523559&form=6&db=m Continuous activation of pituitary adenylate cyclase-activating polypeptide receptors elicits antipodal effects on cyclic AMP and inositol phospholipid signaling pathways in CATH.a cells: role of protein synthesis and protein kinases. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9523568&form=6&db=m Presynaptic GABA(B) receptor modulation of glutamate exocytosis from rat cerebrocortical nerve terminals: receptor decoupling by protein kinase C. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9525480&form=6&db=m Protein tyrosine phosphorylation and calcium signaling in thyroid FRTL-5 cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9525886&form=6&db=m Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9528965&form=6&db=m Angiotensin II activates mitogen-activated protein kinase via protein kinase C and Ras/Raf-1 kinase in bovine adrenal glomerulosa cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9530203&form=6&db=m TAN-67, a delta 1-opioid receptor agonist, reduces infarct size via activation of Gi/o proteins and KATP channels. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9530435&form=6&db=m Prostaglandin E receptors in myometrial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9530821&form=6&db=m Pertussis toxin-sensitive GTP-binding proteins characterized in synaptosomal fractions of embryonic avian cerebral cortex. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9531262&form=6&db=m Dichotomous effects of beta-chemokines on HIV replication in monocytes and monocyte-derived macrophages. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9531979&form=6&db=m Growth regulation of primary human keratinocytes by prostaglandin E receptor EP2 and EP3 subtypes. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9536001&form=6&db=m Agonist and inverse agonist activity at the dopamine D3 receptor measured by guanosine 5'--gamma-thio-triphosphate--35S- binding. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9536019&form=6&db=m Characterization of human neutrophil and endothelial cell ligand-operated extracellular acidification rate by microphysiometry: impact of reoxygenation. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9536948&form=6&db=m Interleukin 1 beta and tumour necrosis factor alpha inhibit acid secretion in cultured rabbit parietal cells by multiple pathways. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9537596&form=6&db=m Melatonin receptors in benign prostate epithelial cells: evidence for the involvement of cholera and pertussis toxins-sensitive G proteins in their signal transduction pathways. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9537824&form=6&db=m Homologous and heterologous desensitisation of somatostatin-induced increases in intracellular Ca2+ and inositol 1,4,5-trisphosphate in CHO-K1 cells expressing human recombinant somatostatin sst5 receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9543256&form=6&db=m Substance P-related inhibitors of mast cell exocytosis act on G-proteins or on the cell surface. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9547350&form=6&db=m A G protein beta gamma dimer-mediated pathway contributes to mitogen-activated protein kinase activation by thyrotropin-releasing hormone receptors in transfected COS-7 cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9547380&form=6&db=m Modulation of Ca2+ channel currents of acutely dissociated rat periaqueductal grey neurons. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9548216&form=6&db=m Age-related loss of calcitriol stimulation of phosphoinositide hydrolysis in rat skeletal muscle. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9549048&form=6&db=m Recruitment of individually (all-or-none) responding cells, rather than amplitude enhancement, is the single-cell mechanism subserving the dose-responsive activation of intracellular calcium second messenger signaling by the human luteinizing-hormone receptor. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9549052&form=6&db=m Decreased insulin content and secretion in RIN 1046-38 cells overexpressing alpha 2-adrenergic receptors. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9551924&form=6&db=m Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: ligand binding, biological activity, and HIV-1 infectivity. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9552368&form=6&db=m G-protein-mediated signal transduction for meiosis reinitiation in starfish oocyte. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9553056&form=6&db=m Requirement for Rho-mediated myosin light chain phosphorylation in thrombin-stimulated cell rounding and its dissociation from mitogenesis. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9553093&form=6&db=m Agonist occupation of an alpha2A-adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-G protein activation stoichiometry. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9555065&form=6&db=m Differential localization of the mRNAs for the pertussis toxin insensitive G-protein alpha sub-units Gq, G11, and Gz in the rat brain, and regulation of their expression after striatal deafferentation. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9556056&form=6&db=m 1,25(OH)2D3 regulates protein kinase C activity through two phospholipid-dependent pathways involving phospholipase A2 and phospholipase C in growth zone chondrocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9556135&form=6&db=m Interleukin-6 synthesis induced by prostaglandin E2: cross-talk regulation by protein kinase C. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9556205&form=6&db=m Midkine induces histamine release from mast cells and the immediate cutaneous response. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9556582&form=6&db=m Differential regulation of formyl peptide and platelet-activating factor receptors. Role of phospholipase Cbeta3 phosphorylation by protein kinase A. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9559902&form=6&db=m Pharmacological comparison of UTP- and thapsigargin-induced arachidonic acid release in mouse RAW 264.7 macrophages. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9560446&form=6&db=m Characterization of ion currents elicited by a stream of fluid during spontaneous and ligand-induced chloride current oscillation in Xenopus laevis oocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9562684&form=6&db=m The effect of pertussis toxin and whole-cell pertussis vaccine on haemodynamics and autonomic responsiveness in the rat depends on route of administration and age. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9563506&form=6&db=m The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9563629&form=6&db=m Signaling pathways for tissue factor expression in lipopolysaccharide-stimulated bovine alveolar macrophages. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9564832&form=6&db=m Evidence for inhibition by protein kinase A of receptor/G alpha(q)/phospholipase C (PLC) coupling by a mechanism not involving PLCbeta2. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9565252&form=6&db=m Thermal injury induces macrophage hyperactivity through pertussis toxin-sensitive and -insensitive pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9566019&form=6&db=m M1, M3 and M5 muscarinic receptors stimulate mitogen-activated protein kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9568725&form=6&db=m Inhibition of adenylyl cyclase by alpha chemokines IL-8 and GRO-alpha in Chinese hamster ovary cells expressing R1 and R2 receptors. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9569476&form=6&db=m Effect of combination with an acellular pertussis, diphtheria, tetanus vaccine on antibody response to Hib vaccine (PRP-T). therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9570479&form=6&db=m Angiotensin II stimulation of the stress-activated protein kinases in renal mesangial cells is mediated by the angiotensin AT1 receptor subtype. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9570563&form=6&db=m The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophils. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9572295&form=6&db=m Functional coupling of the NK1 tachykinin receptor to phospholipase D in chinese hamster ovary cells and astrocytoma cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9572301&form=6&db=m Activation of microtubule-associated protein kinase (Erk) and p70 S6 kinase by D2 dopamine receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9572474&form=6&db=m Altered expression of inhibitory guanine nucleotide regulatory proteins (Gi-proteins) in experimental hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9572479&form=6&db=m Signaling pathways mediating induction of the early response genes prostaglandin G/H synthase-2 and egr-1 by serotonin via 5-HT2A receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9572480&form=6&db=m Activation of p42/p44 mitogen-activated protein kinase by angiotensin II, vasopressin, norepinephrine, and prostaglandin F2alpha in hepatocytes is sustained, and like the effect of epidermal growth factor, mediated through pertussis toxin-sensitive mechanisms. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9573029&form=6&db=m Constitutive chemokine production results in activation of leukocyte function-associated antigen-1 on adult T-cell leukemia cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9573538&form=6&db=m High glucose concentration causes a rise in [Ca2+]i of cardiac myocytes. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9574559&form=6&db=m Leukotriene B4 activates the NADPH oxidase in eosinophils by a pertussis toxin-sensitive mechanism that is largely independent of arachidonic acid mobilization. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9574822&form=6&db=m The tachykinin NK1 receptor. Part I: ligands and mechanisms of cellular activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9574905&form=6&db=m Expression of the mammalian calcium signaling response to Trypanosoma cruzi in Xenopus laevis oocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9575287&form=6&db=m Inhibition of N- and P/Q-type calcium channels by postsynaptic GABAB receptor activation in rat supraoptic neurones. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9575824&form=6&db=m ERK2 mediates oxytocin-stimulated PGE2 synthesis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9575936&form=6&db=m Do beta 2-adrenergic receptors modulate Ca2+ in adult rat ventricular myocytes? therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9576608&form=6&db=m Multiple hypothalamic factors regulate pyroglutamyl peptidase II in cultures of adenohypophyseal cells: role of the cAMP pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9578554&form=6&db=m Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9578616&form=6&db=m Components of the signaling pathway linking the 1-methyladenine receptor to MPF activation and maturation in starfish oocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9579741&form=6&db=m Acetylcholine modulation of high-voltage-activated calcium channels in the neurones acutely dissociated from rat paratracheal ganglia. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9580566&form=6&db=m GTPgammaS-induced actin polymerisation in vitro: ATP- and phosphoinositide-independent signalling via Rho-family proteins and a plasma membrane-associated guanine nucleotide exchange factor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9580633&form=6&db=m Guanine nucleotide-binding inhibitory protein-mediated inhibition of adenylyl cyclase is enhanced in spontaneously hypertensive rat preglomerular arteriolar smooth muscle cells. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9581652&form=6&db=m Involvement of kappa-opioids in the mouse cerebellar adenosinergic modulation of ethanol-induced motor incoordination. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9582224&form=6&db=m Diverse signal transduction pathways mediated by endogenous P2 receptors in cultured rat cerebral cortical neurons. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9582356&form=6&db=m ADP-ribosylation factor and Rho proteins mediate fMLP-dependent activation of phospholipase D in human neutrophils. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9584224&form=6&db=m Protean agonism at alpha2A-adrenoceptors. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9585172&form=6&db=m The delta2-opioid receptor subtype stimulates phosphoinositide metabolism in mouse periaqueductal gray matter. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9589368&form=6&db=m Calcium mobilization and protease-activated receptor cleavage after thrombin stimulation in motor neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9590266&form=6&db=m Quercetin sensitizes RBL-2H3 cells to polybasic mast cell secretagogues through increased expression of Gi GTP-binding proteins linked to a phospholipase C signaling pathway. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9590437&form=6&db=m Cytotoxic action of lindane in cerebellar granule neurons is mediated by interaction with inducible GABA(B) receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9591325&form=6&db=m Effect of 5-hydroxytryptamine on intracellular calcium dynamics in cultured rat vascular smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9592021&form=6&db=m Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9592025&form=6&db=m Effect of alpha2-adrenoceptor stimulation on isolated canine Purkinje fiber contraction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9592059&form=6&db=m Glucose uptake by C6 glioma cells is mediated by G(q alpha). ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9592394&form=6&db=m Homologous and heterologous protection after single intranasal administration of live attenuated recombinant Bordetella pertussis. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9593295&form=6&db=m Analyses of the cag pathogenicity island of Helicobacter pylori. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9594015&form=6&db=m Accentuated antagonism by angiotensin II on guinea-pig cardiac L-type Ca-currents enhanced by beta-adrenergic stimulation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9595304&form=6&db=m Vanadate changes Ca2+ influx pathway properties in human red blood cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9596628&form=6&db=m Rhizobium nod factor signaling. Evidence for a g protein-mediated transduction mechanism unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9596757&form=6&db=m Pasteurella haemolytica A1-derived leukotoxin and endotoxin induce intracellular calcium elevation in bovine alveolar macrophages by different signaling pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9596796&form=6&db=m Characteristics of nitric oxide-mediated cholinergic modulation of calcium current in rabbit sino-atrial node. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9600073&form=6&db=m The neuropeptide Y/peptide YY Y1 receptor is coupled to MAP kinase via PKC and Ras in CHO cells. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9600577&form=6&db=m Effect of pertussis toxin on baclofen- and diphenhydramine-induced amnesia. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9600641&form=6&db=m Adaptations to chronic agonist exposure of mu-opioid receptor-expressing Chinese hamster ovary cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9600664&form=6&db=m Breast cancer cell response to calcitonin: modulation by growth-regulating agents. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9603209&form=6&db=m Metabotropic glutamate receptor agonists potentiate cyclic AMP formation induced by forskolin or beta-adrenergic receptor activation in cerebral cortical astrocytes in culture. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9605111&form=6&db=m Atherogenic lipoproteins enhance mesangial cell expression of platelet-derived growth factor: role of protein tyrosine kinase and cyclic AMP-dependent protein kinase A. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9606019&form=6&db=m The M2 muscarinic receptor antagonist methoctramine activates mast cells via pertussis toxin-sensitive G proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9606021&form=6&db=m Effects of phosducin on the GTPase cycle of Go. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9606725&form=6&db=m Inverse agonism at adrenergic and opioid receptors: studies with wild type and constitutively active mutant receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9607064&form=6&db=m The efficacy of a whole cell pertussis vaccine and fimbriae against Bordetella pertussis and Bordetella parapertussis infections in a respiratory mouse model. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9607407&form=6&db=m Angiotensin II AT1 receptor/signaling mechanisms in the biphasic effect of the peptide on proximal tubular Na+,K+-ATPase. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9608014&form=6&db=m Sensitivity of norepinephrine-evoked vasoconstriction to pertussis toxin in the old rat. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9611120&form=6&db=m Glucagon-mediated Ca2+ signaling in BHK cells expressing cloned human glucagon receptors. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9611122&form=6&db=m Growth factor-like action of lysophosphatidic acid on human B lymphoblasts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9612216&form=6&db=m Neuropeptide Y inhibition of calcium channels in PC-12 pheochromocytoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9612296&form=6&db=m Carbachol-induced actin reorganization involves Gi activation of Rho in human airway smooth muscle cells. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9613607&form=6&db=m Functional coupling between human E-type Ca2+ channels and mu opioid receptors expressed in Xenopus oocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9614143&form=6&db=m Regulation of alphaIIb beta3 function in human B lymphocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9614219&form=6&db=m Gi- and protein kinase C-mediated heterologous potentiation of phospholipase C signaling by G protein-coupled receptors. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9614355&form=6&db=m Galanin inhibits glucagon-like peptide-1 secretion through pertussis toxin-sensitive G protein and ATP-dependent potassium channels in rat ileal L-cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9618307&form=6&db=m Adenosine receptor mediates motility in human melanoma cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9621280&form=6&db=m Dopamine regulates phosphate uptake by opossum kidney cells through multiple counter-regulatory receptors. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9621455&form=6&db=m Involvement of protein kinase and G proteins in the signal transduction of benzophenanthridine alkaloid biosynthesis. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9622608&form=6&db=m Atrial natriuretic peptide modulates alveolar type 2 cell adenylyl and guanylyl cyclases and inhibits surfactant secretion. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9623766&form=6&db=m Resistance of the insulinotropic action of alpha-D-glucose and beta-L-glucose pentaacetates to cholera and pertussis toxins. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9626627&form=6&db=m Influence of aluminum on the regulation of PTH- and 1,25(OH)2D3-dependent pathways in the rat osteosarcoma cell line ROS 17/2.8. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9627590&form=6&db=m Antibody responses and persistence in the two years after immunization with two acellular vaccines and one whole-cell vaccine against pertussis. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9629268&form=6&db=m Signaling through delta opioid receptors on murine splenic T cells and stably transfected Jurkat cells. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9630670&form=6&db=m Adenosine potentiates the delayed-rectifier potassium conductance but has no effect on the hyperpolarization-activated Ih current in frog melanotrophs. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9631546&form=6&db=m Serum resistance in bvg-regulated mutants of Bordetella pertussis. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9632725&form=6&db=m Identification of single C motif-1/lymphotactin receptor XCR1. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9637364&form=6&db=m Characterization of mastoparan-induced histamine release from RBL-2H3 cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9637723&form=6&db=m Endothelin-1 is synthesized and inhibits cyclic adenosine monophosphate- dependent anion secretion by an autocrine/paracrine mechanism in gallbladder epithelial cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9639021&form=6&db=m Muscarinic inhibition of L-type Ca2+ channels in guinea-pig tracheal smooth muscle cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9639284&form=6&db=m Rat striatal adenosinergic modulation of ethanol-induced motor impairment: possible role of striatal cyclic AMP. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9642323&form=6&db=m Some changes of receptor and postreceptor signal transduction regulated by somatostatin in pituitary hGH-secreting adenomas. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9644236&form=6&db=m Suppression of the carbachol-activated nonselective cationic current by antibody against alpha subunit of Go protein in guinea-pig gastric myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9645613&form=6&db=m Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9645940&form=6&db=m Chemotaxis of chinese hamster ovary cells expressing the human neutrophil formyl peptide receptor: role of signal transduction molecules and alpha5beta1 integrin. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9648828&form=6&db=m Glucose augmentation of mastoparan-stimulated insulin secretion in rat and human pancreatic islets. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9648872&form=6&db=m Pertussis toxin modification of PC12 cells inhibits a protein phosphatase 2A-like phosphatase. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9649570&form=6&db=m Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase- dependent pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9649922&form=6&db=m Growth response of human coronary smooth muscle cells to angiotensin II and influence of angiotensin AT1 receptor blockade. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9650833&form=6&db=m P2 receptor-mediated inhibition of adenylyl cyclase in PC12 cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9650840&form=6&db=m Concomitant regulation of Ca2+ mobilization and G13 expression in human erythroleukemia cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9651200&form=6&db=m P2Y2 nucleotide receptors expressed heterologously in sympathetic neurons inhibit both N-type Ca2+ and M-type K+ currents. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9652376&form=6&db=m Muscarinic cation current and suppression of Ca2+ current in guinea pig ileal smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9653130&form=6&db=m gp120 envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by coreceptors CXCR4 and CCR5. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9654360&form=6&db=m ATP produces potassium currents via P3 purinoceptor in the follicle cell layer of Xenopus oocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9655176&form=6&db=m Endothelin-1 and insulin activate the steady-state voltage dependent R-type Ca2+ channel in aortic smooth muscle cells via a pertussis toxin and cholera toxin sensitive G-protein. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9655508&form=6&db=m Kainate receptor modulation of GABA release involves a metabotropic function. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9655856&form=6&db=m Sigma ligands stimulate the electrical activity of frog pituitary melanotrope cells through a G-protein-dependent inhibition of potassium conductances. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9655872&form=6&db=m Effects of nitric oxide on adenylyl cyclase stimulation in N18TG2 neuroblastoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9655882&form=6&db=m 3H-naloxone benzoylhydrazone binding in MOR-1-transfected Chinese hamster ovary cells: evidence for G-protein-dependent antagonist binding. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9657072&form=6&db=m Relationships between dopamine-induced changes in cytosolic free calcium concentration ([Ca2+]i) and rate of prolactin secretion. Elevated [Ca2+]i does not indicate prolactin release. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9658197&form=6&db=m Regulation of adenylyl cyclase type V/VI in smooth muscle: interplay of inhibitory G protein and Ca2+ influx. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9660185&form=6&db=m NMR studies on the structure/function correlations of T-cell-epitope analogs from pertussis toxin. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9660770&form=6&db=m Aerolysin induces G-protein activation and Ca2+ release from intracellular stores in human granulocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9662126&form=6&db=m Signal pathways that transduce growth factor-stimulated mitogenesis in bone cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9662335&form=6&db=m Lysophosphatidic acid-induced association of SHP-2 with SHPS-1: roles of RHO, FAK, and a SRC family kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9663394&form=6&db=m Ras-independent activation of Ral by a Ca(2+)-dependent pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9663688&form=6&db=m Natural competence for DNA transformation in Helicobacter pylori: identification and genetic characterization of the comB locus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9665286&form=6&db=m Blood mononuclear cell production of TNF-alpha and IL-8: engagement of different signal transduction pathways including the p42 MAP kinase pathway. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9665338&form=6&db=m Prostaglandins induce calcium influx in human spermatozoa. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9665372&form=6&db=m Stimulus-dependent transduction mechanisms for nitric oxide release in human polymorphonuclear neutrophil leukocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9666274&form=6&db=m Cannabinoid receptors and the cytokine network. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9669505&form=6&db=m Mitogenic activity of endothelin on human cultured prostatic smooth muscle cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9670207&form=6&db=m Transforming growth factor-beta-mediated proliferation of renal tubular epithelial cells involves pertussis toxin-sensitive G protein-and protein kinase C-dependent pathways. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9670974&form=6&db=m Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9671120&form=6&db=m Characterization of the alpha1-adrenergic chronotropic response in neuropeptide Y-treated cardiomyocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9673264&form=6&db=m Cytokine mRNA expression and proliferative responses induced by pertussis toxin, filamentous hemagglutinin, and pertactin of Bordetella pertussis in the peripheral blood mononuclear cells of infected and immunized schoolchildren and adults. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9674568&form=6&db=m Biphasic modulation of intracellular Ca2+ concentration by interleukin-1beta in cortical synaptosomes: involvement of a pertussis toxin-sensitive G-protein and mitogen-activated protein kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9674691&form=6&db=m Cellular mechanisms of melatonin action. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9674992&form=6&db=m Molecular mechanisms of adenylyl cyclase desensitization in pregnant rat myometrium following in vivo administration of the beta-adrenergic agonist, isoproterenol. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9675156&form=6&db=m Effects of lysophosphatidic acid on proliferation of stellate cells and hepatocytes in culture. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9675277&form=6&db=m Differential regulation of Na+ and Cl- conductances by PTX-sensitive G proteins in fetal lung apical membrane vesicles. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9677414&form=6&db=m The calcitonin receptor stimulates Shc tyrosine phosphorylation and Erk1/2 activation. Involvement of Gi, protein kinase C, and calcium. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679038&form=6&db=m Galanin inhibition of enterochromaffin-like cell function. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679179&form=6&db=m Non-genomic action of the mineralocorticoid aldosterone on cytosolic sodium in cultured kidney cells. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679984&form=6&db=m Differential roles of protein kinase C and pertussis toxin-sensitive G-binding proteins in modulation of melanoma cell proliferation and motility by thrombospondin 1. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9681185&form=6&db=m Thapsigargin and receptor-mediated activation of Drosophila TRPL channels stably expressed in a Drosophila S2 cell line. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9681191&form=6&db=m Heterotrimeric Gi protein is associated with the inositol 1,4,5-trisphosphate receptor complex and modulates calcium flux. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9681455&form=6&db=m Inhibition of dopamine release by prostaglandin EP3 receptor via pertussis toxin-sensitive and -insensitive pathways in PC12 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9681504&form=6&db=m Pharmacological and functional characterization of muscarinic receptors in the frog pars intermedia. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9681928&form=6&db=m Delta-opioid receptors on astroglial cells in primary culture: mobilization of intracellular free calcium via a pertussis sensitive G protein. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9682275&form=6&db=m Adenosinergic modulation of ethanol-induced motor incoordination in the rat motor cortex. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9683437&form=6&db=m Pertussis toxin abolishes the cardioprotective effect of ischemic preconditioning in intact rat heart. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9685362&form=6&db=m Activation of phospholipase C-beta1 via Galphaq/11 during calcium mobilization by calcitonin gene-related peptide. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9685638&form=6&db=m In vivo IL-1beta-induced modulation of G-protein alphaO subunit subclass in the hypothalamic ventromedial nucleus: implications to IL-1beta-associated anorexia. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9685862&form=6&db=m Intracellular Signal-transducing elements involved in transendothelial migration of lymphoma cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9687531&form=6&db=m Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1 (SDF-1) enhances platelet formation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9687538&form=6&db=m HIV-specific T cell cytotoxicity mediated by RANTES via the chemokine receptor CCR3. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9687565&form=6&db=m Selective activation of a chimeric Gi1/Gs G protein alpha subunit by the human IP prostanoid receptor: analysis using agonist stimulation of high affinity GTPase activity and [35S]guanosine-5'-O-(3-thio)triphosphate binding. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9688329&form=6&db=m Secretoneurin and chemoattractant receptor interactions. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9688646&form=6&db=m Signal transduction pathways mediating CCK-induced gallbladder muscle contraction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9688922&form=6&db=m PTX-sensitive G proteins and permissive action of prostacyclin in newborn pig cerebral circulation. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9690871&form=6&db=m 5-HT potentiation of the GABA(A) response in the rat sacral dorsal commissural neurones. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9692755&form=6&db=m Post- and presynaptic GABA(B) receptor activation in neonatal rat rostral ventrolateral medulla neurons in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9692884&form=6&db=m Eotaxin-2 activates chemotaxis-related events and release of reactive oxygen species via pertussis toxin-sensitive G proteins in human eosinophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9694224&form=6&db=m Human metabotropic glutamate receptor 2 couples to the MAP kinase cascade in chinese hamster ovary cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9694564&form=6&db=m Regulation of adrenocortical function by vasopressin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9694839&form=6&db=m Activation of mitogen-activated protein kinases by formyl peptide receptors is regulated by the cytoplasmic tail. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9694908&form=6&db=m Protean effects of a natural peptide agonist of the G protein-coupled secretin receptor demonstrated by receptor mutagenesis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9694930&form=6&db=m Identification and characterization of muscarinic receptors potentiating the stimulation of adenylyl cyclase activity by corticotropin-releasing hormone in membranes of rat frontal cortex. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9695117&form=6&db=m Amplification of alpha 1D-adrenoceptor mediated contractions in rat aortic rings partially depolarised with KCl. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9696351&form=6&db=m Involvement of a Gardos-type potassium channel in head activator-induced mitosis of BON cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9697993&form=6&db=m Characterization of the murine immune response to the murine TSH receptor ectodomain: induction of hypothyroidism and TSH receptor antibodies. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9698085&form=6&db=m Functional analysis of the D2L dopamine receptor expressed in a cAMP-responsive luciferase reporter cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9698329&form=6&db=m Differential response of cortical plate and ventricular zone cells to GABA as a migration stimulus. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9704103&form=6&db=m Novel molecular biology approaches to acellular vaccines. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9704634&form=6&db=m Heparan sulfate proteoglycan on endothelium efficiently induces integrin-mediated T cell adhesion by immobilizing chemokines in patients with rheumatoid synovitis. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9705082&form=6&db=m Stable transfection of the rat follicle-stimulating hormone receptor complementary DNA into an immortalized murine Sertoli cell line. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9705607&form=6&db=m cAMP analogues downregulate the expression of granulocyte macrophage colony-stimulating factor (GM-CSF) in human bone marrow stromal cells in vitro. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9706949&form=6&db=m Partial agonistic activity of naloxone on the opioid receptors expressed from complementary deoxyribonucleic acids in Chinese hamster ovary cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9708989&form=6&db=m Threshold and graded response behavior in human neutrophils: effect of varying G-protein or ligand concentrations. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9708991&form=6&db=m Hydrophobicity of residue351 of the G protein Gi1 alpha determines the extent of activation by the alpha 2A-adrenoceptor. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9710257&form=6&db=m Neurotensin type 1 receptor-mediated activation of krox24, c-fos and Elk-1: preventing effect of the neurotensin antagonists SR 48692 and SR 142948. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9711351&form=6&db=m Pertussis toxin modification of PC12 cells lowers cytoskeletal F-actin and enhances norepinephrine secretion: involvement of protein kinase C and protein phosphatases. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9712181&form=6&db=m Regulation of the action of the novel cholecystokinin-releasing peptide diazepam binding inhibitor by inhibitory hormones and taurocholate. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9712891&form=6&db=m A heterotrimeric G protein of the Gi family is required for cAMP-triggered trafficking of aquaporin 2 in kidney epithelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9713935&form=6&db=m Antibody and cell-mediated immune responses to booster immunization with a new acellular pertussis vaccine in school children. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9713945&form=6&db=m Repeated administration of whole-cell and acellular pertussis vaccines affects haemodynamics and autonomic responsiveness. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9714718&form=6&db=m Stimulatory effects of lipoprotein(a) and low-density lipoprotein on human umbilical vein endothelial cell migration and proliferation are partially mediated by fibroblast growth factor-2. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9715266&form=6&db=m Endotoxin activation of mitogen-activated protein kinase in THP-1 cells; diminished activation following endotoxin desensitization. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9716265&form=6&db=m The inflammatory mediator leukotriene D4 triggers a rapid reorganisation of the actin cytoskeleton in human intestinal epithelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9716370&form=6&db=m Magnolol induces cytosolic-free Ca2+ elevation in rat neutrophils primarily via inositol trisphosphate signalling pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9716372&form=6&db=m Pituitary adenylate cyclase activating polypeptide induces multiple signaling pathways in rat peritoneal mast cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9716556&form=6&db=m Gonadotropin-releasing hormone receptor couples to multiple G proteins in rat gonadotrophs and in GGH3 cells: evidence from palmitoylation and overexpression of G proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9720803&form=6&db=m Inhibition of tumour necrosis factor and reversal of endotoxin-induced shock by U-83836E, a 'second generation' lazaroid in rats. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9720805&form=6&db=m Prostaglandins inhibit secretion of histamine and pancreastatin from isolated rat stomach ECL cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9721723&form=6&db=m D2 dopamine receptors stimulate mitogenesis through pertussis toxin-sensitive G proteins and Ras-involved ERK and SAP/JNK pathways in rat C6-D2L glioma cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9721727&form=6&db=m Nociceptin (ORL-1) and mu-opioid receptors mediate mitogen-activated protein kinase activation in CHO cells through a Gi-coupled signaling pathway: evidence for distinct mechanisms of agonist-mediated desensitization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9721730&form=6&db=m Coupling of serotonin 5-HT1B receptors to activation of mitogen-activated protein kinase (ERK-2) and p70 S6 kinase signaling systems. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9721733&form=6&db=m Modulation of [3H]acetylcholine release from cultured amacrine-like neurons by adenosine A1 receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9723886&form=6&db=m Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9723963&form=6&db=m Human adenosine A1 receptor and P2Y2-purinoceptor-mediated activation of the mitogen-activated protein kinase cascade in transfected CHO cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9723967&form=6&db=m Mechanism underlying histamine-induced desensitization of amylase secretion in rat parotid glands. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9724045&form=6&db=m Transcriptional activation of gonadotropin-releasing hormone (GnRH) receptor gene by GnRH and cyclic adenosine monophosphate. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9724272&form=6&db=m Migration of intestinal intraepithelial lymphocytes into a polarized epithelial monolayer. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9726638&form=6&db=m Discrimination between plasma membrane and intracellular target sites of sphingosylphosphorylcholine. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9727041&form=6&db=m High constitutive activity of the human formyl peptide receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9728323&form=6&db=m Contribution of cAMP to the inhibitory effect of non-steroidal anti-inflammatory drugs in rat uterine smooth muscle. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9728508&form=6&db=m Effects of drugs acting on adrenergic and adenosine receptors on the intraocular pressure and the activity of adenylyl cyclase in ciliary processes and their sensitivity to pertussis toxin. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9729473&form=6&db=m Intracellular calcium mobilization and phospholipid degradation in sphingosylphosphorylcholine-stimulated human airway epithelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9729476&form=6&db=m Effects of ethanol on mitogen-activated protein kinase and stress-activated protein kinase cascades in normal and regenerating liver. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9729520&form=6&db=m Peptide YY inhibits vasopressin-stimulated chloride secretion in inner medullary collecting duct cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9729629&form=6&db=m Endogenous peptidergic modulation of perisynaptic Schwann cells at the frog neuromuscular junction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9730954&form=6&db=m Alpha-adrenergic receptors regulate human lymphocyte amiloride-sensitive sodium channels. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9731045&form=6&db=m Eotaxin modulates myelopoiesis and mast cell development from embryonic hematopoietic progenitors. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9731750&form=6&db=m Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9736452&form=6&db=m Chemokine receptor CCR5 functionally couples to inhibitory G proteins and undergoes desensitization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9737341&form=6&db=m Catecholamines stimulate the proliferation and alkaline phosphatase activity of MC3T3-E1 osteoblast-like cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9739102&form=6&db=m Independence of, and interactions between, cannabinoid and opioid signal transduction pathways in N18TG2 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9739417&form=6&db=m Effect of angiotensin converting enzyme (ACE) and angiotensins on human sperm functions. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9741823&form=6&db=m Thrombin signal transduction of the fibrinolytic system in human adult venous endothelium in vitro. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9741835&form=6&db=m Stepwise activation of the gonadotropic signal transduction pathway, and the ability of prostaglandin F2alpha to inhibit this activated pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9742095&form=6&db=m Regulation of myogenesis by fibroblast growth factors requires beta-gamma subunits of pertussis toxin-sensitive G proteins. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9744935&form=6&db=m Serum from diabetic BB/W rats enhances calcium currents in primary sensory neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9746596&form=6&db=m Intestinal secretory factor released by macrophages stimulated with Clostridium difficile toxin A: role of interleukin 1beta. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9748276&form=6&db=m The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9749760&form=6&db=m Modulation of big K+ channel activity by ryanodine receptors and L-type Ca2+ channels in neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9749999&form=6&db=m Inhibition of ATP-induced cAMP formation by 5'-p-fluorosulfonylbenzoyladenosine in NG108-15 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9751480&form=6&db=m Muscarinic regulation of intracellular signaling and neurosecretion in gonadotropin-releasing hormone neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9753091&form=6&db=m Effects of transient oxygen-glucose deprivation on G-proteins and G-protein-coupled receptors in rat CA3 pyramidal cells in vitro. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9753102&form=6&db=m Serotonin depresses excitatory synaptic transmission and depolarization-evoked Ca2+ influx in rat basolateral amygdala via 5-HT1A receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9753128&form=6&db=m Somatostatin receptor subtypes sst1 and sst2 elicit opposite effects on the response to glutamate of mouse hypothalamic neurones: an electrophysiological and single cell RT-PCR study. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9753495&form=6&db=m Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9754929&form=6&db=m Effects of insulin-like growth factor I and II on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9755107&form=6&db=m Role of G proteins in agonist-induced Ca2+ sensitization of tracheal smooth muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9755264&form=6&db=m The effect of investigator compliance (observer bias) on calculated efficacy in a pertussis vaccine trial. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9755273&form=6&db=m Pertussis encephalopathy with high cerebrospinal fluid antibody titers to pertussis toxin and filamentous hemagglutinin. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9755813&form=6&db=m Ca2+ dependent purinergic regulation of p42 and p44 MAP kinases in astroglial cultured cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9756376&form=6&db=m Characterization of an atypical muscarinic cholinoceptor mediating contraction of the guinea-pig isolated uterus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9756380&form=6&db=m Direct dopamine D2-receptor-mediated modulation of arachidonic acid release in transfected CHO cells without the concomitant administration of a Ca2+-mobilizing agent. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9756637&form=6&db=m Regulation of arachidonic acid release and prostaglandin E2 production in thymic epithelial cells by ATPgammaS and transforming growth factor-alpha. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9758168&form=6&db=m Both ET(A) and ET(B) receptors are involved in mitogen-activated protein kinase activation and DNA synthesis of astrocytes: study using ET(B) receptor-deficient rats (aganglionosis rats). therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9758901&form=6&db=m Signal transduction in activation of human eosinophils: G protein-dependent and -independent pathways. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9759889&form=6&db=m Stromal cell-derived factor-1 alpha and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: a potential mechanism for cooperative induction of chemotaxis. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9759967&form=6&db=m Histamine modulates high-voltage-activated calcium channels in neurons dissociated from the rat tuberomammillary nucleus. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9760105&form=6&db=m Nociception activates Elk-1 and Sap1a following expression of the ORL1 receptor in Chinese hamster ovary cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9763460&form=6&db=m Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to nociceptin/orphanin FQ. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9764608&form=6&db=m Enhancement of HIV-1 replication in human macrophages is induced by CD8+ T cell soluble factors. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9765227&form=6&db=m EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9765341&form=6&db=m Modulation by angiotensin II of isoproterenol-induced cAMP production in preglomerular microvascular smooth muscle cells from normotensive and genetically hypertensive rats. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9765400&form=6&db=m Dissemination of lymphocytic choriomeningitis virus from the gastric mucosa requires G protein-coupled signaling. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9769319&form=6&db=m Interaction between neuronal nitric oxide synthase and inhibitory G protein activity in heart rate regulation in conscious mice. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9771891&form=6&db=m Loss of activation of Gs but not Gi following expression of an alpha2A-adrenoceptor-Gi1alpha fusion protein. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9771902&form=6&db=m P2Y receptor subtypes differentially couple to inwardly-rectifying potassium channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9771917&form=6&db=m Regulation of delta opioid receptors by delta9-tetrahydrocannabinol in NG108-15 hybrid cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9772248&form=6&db=m Vasopressin-induced currents in rat neonatal spinal lateral horn neurons are G-protein mediated and involve two conductances. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9774224&form=6&db=m Diminution of contractile response by kappa-opioid receptor agonists in isolated rat ventricular cardiomyocytes is mediated via a pertussis toxin-sensitive G protein. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9774361&form=6&db=m Role of calcium-sensitive tyrosine kinase Pyk2/CAKbeta/RAFTK in angiotensin II induced Ras/ERK signaling. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9776362&form=6&db=m Molecular cloning and functional characterization of a rat somatostatin sst2(b) receptor splice variant. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9776379&form=6&db=m Functional coupling of human metabotropic glutamate receptor hmGlu1d: comparison to splice variants hmGlu1a and -1b. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9779002&form=6&db=m [Inactivation and toxoiding of biologically-active components of Bordetella pertussis by tea catechins] ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9780316&form=6&db=m Chronic oxytocin pretreatment inhibits adenylyl cyclase activity in cultured rat myometrial cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9781669&form=6&db=m Enhanced fMLP-stimulated chemotaxis in human neutrophils from individuals carrying the G protein beta3 subunit 825 T-allele. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9782118&form=6&db=m Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9783906&form=6&db=m Heterotrimeric G-protein candidates for Ge in the ACTH secretory pathway. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9786888&form=6&db=m Receptor-independent activation of atrial muscarinic potassium channels in the absence of nucleotides. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9786976&form=6&db=m Selective activation of Galphao by D2L dopamine receptors in NS20Y neuroblastoma cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9789057&form=6&db=m HIV-1 Tat protein mimicry of chemokines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9789117&form=6&db=m Blockade of Ca2+-activated K+ channels inhibits proliferation of human endothelial cells induced by basic fibroblast growth factor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9792105&form=6&db=m Topological mimicry and epitope duplication in the guanylyl cyclase C receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9792418&form=6&db=m Intracellular dynamics of alkaline phosphatase-containing granules in electropermeabilized human neutrophils. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9792916&form=6&db=m Activation of c-Jun N-terminal kinase (JNK) by lysophosphatidic acid in Swiss 3T3 fibroblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9793684&form=6&db=m Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9796041&form=6&db=m A search for serologic correlates of immunity to Bordetella pertussis cough illnesses. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9796042&form=6&db=m Levels of anti-pertussis antibodies related to protection after household exposure to Bordetella pertussis. causal interaction,diagnostic usage,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9796053&form=6&db=m Assessment of the immunogenicity and reactogenicity of a quadrivalent diphtheria, tetanus, acellular pertussis and hepatitis B (DTPa-HBV) vaccine administered in a single injection with Haemophilus influenzae type b conjugate vaccine, to infants at 2, 4 and 6 months of age. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9796062&form=6&db=m Stimulation of mucosal and systemic antibody responses against Bordetella pertussis filamentous haemagglutinin and recombinant pertussis toxin after nasal administration with chitosan in mice. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9797479&form=6&db=m Activation of phospholipase D signaling pathway by epidermal growth factor in osteoblastic cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9798918&form=6&db=m Characterization of the phosphoinositide-linked dopamine receptor in a mouse hippocampal-neuroblastoma hybrid cell line. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9798946&form=6&db=m Activation of phospholipase A2 by the nociceptin receptor expressed in Chinese hamster ovary cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9798948&form=6&db=m Pertussis toxin-insensitive signaling of the ORL1 receptor: coupling to Gz and G16 proteins. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9799646&form=6&db=m Inactivation of (Gialpha) proteins increases arrhythmogenic effects of beta-adrenergic stimulation in the heart. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9799662&form=6&db=m Phospholipase C inhibitors attenuate arrhythmias induced by kappa-receptor stimulation in the isolated rat heart. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9802327&form=6&db=m Pharmacological characterisation of melatonin mt1 receptor-mediated stimulation of [35S]-GTPgammaS binding. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9802409&form=6&db=m Effect of BIBP3226 on inositol phosphate accumulation and cytosolic calcium level in control and NPY Y1 receptor expressing CHO-K1 cells. causal interaction,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9802411&form=6&db=m Neuropeptide Y Y1 and Y2 receptor-mediated stimulation of mitogen-activated protein kinase activity. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9802887&form=6&db=m Mechanism of rhinovirus-induced changes in airway smooth muscle responsiveness. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9804618&form=6&db=m Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9804623&form=6&db=m Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9806324&form=6&db=m The role of A3 adenosine receptors in central regulation of arterial blood pressure. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9806342&form=6&db=m A1 and A2 adenosine receptor modulation of contractility in the cauda epididymis of the guinea-pig. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9806967&form=6&db=m Mechanism of peptide-induced mast cell degranulation. Translocation and patch-clamp studies. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9808689&form=6&db=m Delta opioid receptor down-regulation is independent of functional G protein yet is dependent on agonist efficacy. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9809986&form=6&db=m Mechanism of inhibition of a tumor lipid-mobilizing factor by eicosapentaenoic acid. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9813023&form=6&db=m Regulators of G protein signaling (RGS) proteins constitutively activate Gbeta gamma-gated potassium channels. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9814968&form=6&db=m Intracellular signaling leads to the hypertrophic effect of neuropeptide Y. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9814974&form=6&db=m Sphingosylphosphorylcholine stimulates mitogen-activated protein kinase via a Ca2+-dependent pathway. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9815090&form=6&db=m Atrial natriuretic peptide clearance receptor participates in modulating endothelial permeability. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9815118&form=6&db=m A1 adenosine receptor-mediated Ins(1,4,5)P3 generation in allergic rabbit airway smooth muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9816673&form=6&db=m Pertussis toxin-sensitive G protein that supports vitellogenin uptake by promoting patency. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9820828&form=6&db=m Stimulatory and inhibitory actions of lysophosphatidylcholine, depending on its fatty acid residue, on the phospholipase C/Ca2+ system in HL-60 leukaemia cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9822693&form=6&db=m Signaling mechanisms underlying muscarinic receptor-mediated increase in contraction rate in cultured heart cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9822768&form=6&db=m Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9822894&form=6&db=m Carbachol inhibition of Ca2+ currents in ventricular cells obtained from neonatal and adult rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9824472&form=6&db=m MAPkinase: a second site of G-protein regulation of B-cell activation via the antigen receptors. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9824660&form=6&db=m Interaction of the alpha-2 adrenergic- and opioid receptor with the cGMP system in the mouse cerebellum. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9824686&form=6&db=m Modulation of agonist binding to recombinant human alpha2-adrenoceptors by sodium ions. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9824716&form=6&db=m Heterologous expression and coupling of G protein-gated inwardly rectifying K+ channels in adult rat sympathetic neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9826060&form=6&db=m Independent coupling of the human tachykinin NK2 receptor to phospholipases C and A2 in transfected Chinese hamster ovary cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9826374&form=6&db=m Filamentous hemagglutinin of Bordetella bronchiseptica is required for efficient establishment of tracheal colonization. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9826783&form=6&db=m Different proliferative responses of Gi/o-protein-coupled receptors in human myometrial smooth muscle cells. A possible role of calcium. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9826913&form=6&db=m Na(+)-dependent metabolic coupling upon 5-HT1B receptor activation by sumatriptan and related agonists. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9828362&form=6&db=m Biosensing with G-protein coupled receptor systems. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9831890&form=6&db=m The 5-HT4 receptor antagonist ML10375 inhibits the constitutive activity of human 5-HT4(c) receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9831922&form=6&db=m Differential agonist activity of somatostatin and L-362855 at human recombinant sst4 receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9832122&form=6&db=m The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9832129&form=6&db=m Colocalization and complex formation between prosaposin and monosialoganglioside GM3 in neural cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9832140&form=6&db=m Presynaptic inhibition by concanavalin A: are alpha-latrotoxin receptors involved in action potential-dependent transmitter release? ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9832416&form=6&db=m Inhibition of voltage-dependent calcium channels by prostaglandin E2 in rat melanotrophs. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9832449&form=6&db=m Nongenomic mechanisms of glucocorticoid inhibition of nicotine-induced calcium influx in PC12 cells: involvement of protein kinase C. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9838061&form=6&db=m Anaphylatoxins C5a and C3a induce nuclear factor kappaB activation in human peripheral blood monocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9838128&form=6&db=m Somatostatin enhances neurite outgrowth in PC12 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9839547&form=6&db=m Insulin-induced expression of prostacyclin receptors on platelets is mediated through ADP-ribosylation of Gi alpha protein. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9839818&form=6&db=m Some new insights into the effects of opioids in phasic and tonic nociceptive tests. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9840417&form=6&db=m Native 5-HT1B receptors expressed in OK cells display dual coupling to elevation of intracellular calcium concentrations and inhibition of adenylate cyclase. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9840418&form=6&db=m Activation of a Ca2+-dependent K+ current in mouse fibroblasts by lysophosphatidic acid requires a pertussis toxin-sensitive G protein and Ras. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9841498&form=6&db=m Functional and molecular evidence for P2X receptors in LLC-PK1 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9843377&form=6&db=m Agonist-mediated downregulation of G alpha i via the alpha 2-adrenergic receptor is targeted by receptor-Gi interaction and is independent of receptor signaling and regulation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9843397&form=6&db=m Interleukin-8 receptors R1 and R2 activate mitogen-activated protein kinases and induce c-fos, independent of Ras and Raf-1 in Chinese hamster ovary cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9843699&form=6&db=m G protein-dependent activation of smooth muscle eNOS via natriuretic peptide clearance receptor. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9843831&form=6&db=m Depression of excitability by sphingosine 1-phosphate in rat ventricular myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9843907&form=6&db=m Prostanoid signaling, localization, and expression of IP receptors in rat thick ascending limb cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9843923&form=6&db=m Human airway epithelial monolayers promote selective transmigration of memory T cells: a transepithelial model of lymphocyte migration into the airways. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9846160&form=6&db=m cAMP-dependent inhibition is dominant in regulating superoxide production in the bone-resorbing osteoclasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9849890&form=6&db=m Activation of muscarinic K+ current by beta-adrenergic receptors in cultured atrial myocytes transfected with beta1 subunit of heterotrimeric G proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9850337&form=6&db=m Chemotaxins C5a and fMLP induce release of calprotectin (leucocyte L1 protein) from polymorphonuclear cells in vitro. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9850743&form=6&db=m Vasoactive intestinal peptide and epidermal growth factor: co-mitogens or inhibitors of keratinocyte proliferation in vitro? ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9852323&form=6&db=m Isoprenaline can activate the acetylcholine-induced K+ current in canine atrial myocytes via Gs-derived betagamma subunits. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9854026&form=6&db=m The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9855426&form=6&db=m Standardization of acellular pertussis vaccine by assay of serum neutralizing antibodies to pertussis toxin (antitoxin): analogy with diphtheria toxoid. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9855640&form=6&db=m Functional coupling of human L-type Ca2+ channels and angiotensin AT1A receptors coexpressed in xenopus laevis oocytes: involvement of the carboxyl-terminal Ca2+ sensors. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9857618&form=6&db=m [Evaluation of the usefulness of Bordetella pertussis toxins for serodiagnosis of whooping cough] diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9860239&form=6&db=m Eosinophil leukocyte degranulation in response to serum-opsonized beads: C5a and platelet-activating factor enhance ECP release, with roles for protein kinases A and C. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9862775&form=6&db=m GalphaL1 (Galpha14) couples the opioid receptor-like1 receptor to stimulation of phospholipase C. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9862860&form=6&db=m Monocyte chemotactic protein-1 as a chemoattractant for human hepatic stellate cells. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9862909&form=6&db=m Inhibition of calcium currents in rat colon sensory neurons by K- but not mu- or delta-opioids. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9863156&form=6&db=m Oxytocin-stimulated insulin release in a clonal beta-cell line RINm5F: involvement of phospholipase C-dependent and -independent pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9863646&form=6&db=m Functional cross-talk between endothelial muscarinic and alpha2-adrenergic receptors in rabbit cerebral arteries. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9863648&form=6&db=m Mechanism of ET(A)-receptor stimulation-induced increases in intracellular Ca2+ in SK-N-MC cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9864250&form=6&db=m Nonrestricted differential intoxication of cells by pertussis toxin. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9865521&form=6&db=m The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9867216&form=6&db=m Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9870915&form=6&db=m Regulation of the G protein Galphai2 by growth and development in fetal airway epithelium. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9872564&form=6&db=m Regulation of ion content in primary cultures from reabsorptive ducts of human sweat glands studied by X-ray microanalysis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9872996&form=6&db=m Evidence for a beta2-adrenergic/arachidonic acid pathway in ventricular cardiomyocytes. Regulation by the beta1-adrenergic/camp pathway. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9873032&form=6&db=m Differences in the regulation of fibroblast contraction of floating versus stressed collagen matrices. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9873202&form=6&db=m Delta opiate receptors account for the castration-induced unmasking of gonadotropin-releasing hormone binding sites in the rat pituitary. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9874176&form=6&db=m Angiotensin AT1 receptors in Clone 9 rat liver cells: Ca2+ signaling and c-fos expression. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9876304&form=6&db=m Histopathological analysis of rat mesentery as a method for evaluating neutrophil migration: differential effects of dexamethasone and pertussis toxin. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9877154&form=6&db=m The CGRP receptor can couple via pertussis toxin sensitive and insensitive G proteins. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9877167&form=6&db=m Chimeric Galpha(q) mutants harboring the last five carboxy-terminal residues of Galpha(i2) or Galpha(o) are resistant to pertussis toxin-catalyzed ADP-ribosylation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9879066&form=6&db=m [3H]-BIBP3226 and [3H]-NPY binding to intact SK-N-MC cells and CHO cells expressing the human Y1 receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9879654&form=6&db=m GTP-binding protein mediated phospholipase A2 activation in rat liver during the progression of sepsis. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9880594&form=6&db=m ATP stimulates sympathetic transmitter release via presynaptic P2X purinoceptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9881591&form=6&db=m Corticotropin-releasing factor induces phosphorylation of phospholipase C-gamma at tyrosine residues via its receptor 2beta in human epidermoid A-431 cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9881872&form=6&db=m Co-existence of two types of [Ca2+]i-inducing protease-activated receptors (PAR-1 and PAR-2) in rat astrocytes and C6 glioma cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9882428&form=6&db=m Regulation of guanine nucleotide turnover on Gi/Go by agonist-stimulated and spontaneously active muscarinic receptors in cardiac membranes. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9882612&form=6&db=m Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9882706&form=6&db=m Possible involvement of cell surface receptors in sphingosine 1-phosphate-induced activation of extracellular signal-regulated kinase in C6 glioma cells. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9885991&form=6&db=m Molecular and cellular analyses of melatonin receptor-mediated cAMP signaling in rat corpus epididymis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9886417&form=6&db=m Characterization of the signal transduction pathway activated in human monocytes and dendritic cells by MPIF-1, a specific ligand for CC chemokine receptor 1. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9886419&form=6&db=m Regulation of IL-6 synthesis in human peripheral blood mononuclear cells by C3a and C3a(desArg). therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9886753&form=6&db=m Rat somatostatin sst2(a) and sst2(b) receptor isoforms mediate opposite effects on cell proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9886802&form=6&db=m Glicentin and oxyntomodulin modulate both the phosphoinositide and cyclic adenosine monophosphate signaling pathways in gastric myocytes. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9887033&form=6&db=m Mechanism of prejunctional muscarinic receptor-mediated inhibition of neurogenic vasodilation in cerebral arteries. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9887075&form=6&db=m Guanine nucleotide binding proteins in cultured renal epithelia: studies with pertussis toxin and aldosterone. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9888863&form=6&db=m Growth and cell cycle abnormalities of fibroblasts from Tangier disease patients. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9888881&form=6&db=m The proliferative effect of vascular endothelial growth factor requires protein kinase C-alpha and protein kinase C-zeta. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9889388&form=6&db=m Angiotensin II activates the ouabain-insensitive Na+-ATPase from renal proximal tubules through a G-protein. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9892010&form=6&db=m Somatostatin activation of mitogen-activated protein kinase via somatostatin receptor 1 (SSTR1). therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9893158&form=6&db=m Internalization of [DOTA degrees,125I-Tyr3]Octreotide by somatostatin receptor-positive cells in vitro and in vivo: implications for somatostatin receptor-targeted radio-guided surgery. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9914268&form=6&db=m Muscarine modulates Ca2+ channel currents in rat sensorimotor pyramidal cells via two distinct pathways. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9914412&form=6&db=m beta-adrenergic modulation of maxi-K channels in vascular smooth muscle via Gi through a membrane-delimited pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9915578&form=6&db=m Epithelial-mesenchymal transformation in the embryonic heart is mediated through distinct pertussis toxin-sensitive and TGFbeta signal transduction mechanisms. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9915773&form=6&db=m Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9915816&form=6&db=m Galphai is not required for chemotaxis mediated by Gi-coupled receptors. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9916065&form=6&db=m Intracellular delivery of a cytolytic T-lymphocyte epitope peptide by pertussis toxin to major histocompatibility complex class I without involvement of the cytosolic class I antigen processing pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9916087&form=6&db=m Identification and characterization of PtlC, an essential component of the pertussis toxin secretion system. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9918562&form=6&db=m SR 144528, an antagonist for the peripheral cannabinoid receptor that behaves as an inverse agonist. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9918595&form=6&db=m Opioid efficacy in a C6 glioma cell line stably expressing the human kappa opioid receptor. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9918656&form=6&db=m Analyses of secondary structures in DNA by pyrosequencing. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9918917&form=6&db=m Enhanced Gi-protein-mediated mitogenesis following chronic ethanol exposure in a rat model of experimental hepatocellular carcinoma. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9920131&form=6&db=m Time-course of infection and responses in a coughing rat model of pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9920652&form=6&db=m G-proteins are involved in 5-HT receptor-mediated modulation of N- and P/Q- but not T-type Ca2+ channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9920747&form=6&db=m Serum amyloid A induces chemotaxis of human mast cells by activating a pertussis toxin-sensitive signal transduction pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9920763&form=6&db=m Induction of nitric oxide synthase mRNA by shear stress requires intracellular calcium and G-protein signals and is modulated by PI 3 kinase. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9920930&form=6&db=m C3 toxin activates the stress signaling pathways, JNK and p38, but antagonizes the activation of AP-1 in rat-1 cells. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9920937&form=6&db=m Lysophosphatidic acid activates NF-kappaB in fibroblasts. A requirement for multiple inputs. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9924630&form=6&db=m Sphingosylphosphorylcholine and sphingosine-1-phosphate mobilize cytosolic calcium through different mechanisms in human airway epithelial cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9924897&form=6&db=m Muscarinic receptors mediate carbachol-induced inhibition of maximal electroshock seizures in the nucleus reticularis pontis oralis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9925353&form=6&db=m Differential alterations in left and right ventricular G-proteins in congestive heart failure due to myocardial infarction. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9925881&form=6&db=m The role of N-, Q- and R-type Ca2+ channels in feedback inhibition of ACh release from rat basal forebrain neurones. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9927299&form=6&db=m Mitogen-activated protein kinase cascade is involved in endothelin-1-induced rat puerperal uterine contraction. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9927317&form=6&db=m Inhibition of stimulated amylase secretion by adrenomedullin in rat pancreatic acini. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9927404&form=6&db=m Coronary arteriolar dilation to acidosis: role of ATP-sensitive potassium channels and pertussis toxin-sensitive G proteins. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9927616&form=6&db=m Stimulation of the extracellular signal-regulated kinase 1/2 pathway by human beta-3 adrenergic receptor: new pharmacological profile and mechanism of activation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9928006&form=6&db=m Pituitary adenylate cyclase activating polypeptide induces degranulation of rat peritoneal mast cells via high-affinity PACAP receptor-independent activation of G proteins. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9928168&form=6&db=m Galanin activates an inwardly rectifying potassium conductance and inhibits a voltage-dependent calcium conductance in mudpuppy parasympathetic neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9930597&form=6&db=m Pertussis IgE and atopic disease. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9930723&form=6&db=m Chronic ethanol increases the cannabinoid receptor agonist anandamide and its precursor N-arachidonoylphosphatidylethanolamine in SK-N-SH cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9931092&form=6&db=m C-type natriuretic peptide attenuates evoked dopamine efflux by influencing Goalpha. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9933590&form=6&db=m Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9949184&form=6&db=m Activation of nitric oxide release and oxidative metabolism by leukotrienes B4, C4, and D4 in human polymorphonuclear leukocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9950077&form=6&db=m Mechanism of toxic action of fluoride in dental fluorosis: whether trimeric G proteins participate in the disturbance of intracellular transport of secretory ameloblast exposed to fluoride. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9950949&form=6&db=m Lysophosphatidic acid-induced calcium mobilization and proliferation in kidney proximal tubular cells. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9952069&form=6&db=m Short- and long-term heterologous sensitization of adenylate cyclase by D4 dopamine receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9987175&form=6&db=m Vaccination against the gastrointestinal nematode, Haemonchus contortus, using a purified larval surface antigen. diagnostic usage,ongoing research,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9990538&form=6&db=m Non-anticoagulant heparin increases endothelial nitric oxide synthase activity: role of inhibitory guanine nucleotide proteins. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10022233&form=6&db=m Inhibition of the cAMP signaling cascade via cannabinoid receptors: a putative mechanism of immune modulation by cannabinoid compounds. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10024007&form=6&db=m D2S, D2L, D3, and D4 dopamine receptors couple to a voltage-dependent potassium current in N18TG2 x mesencephalon hybrid cell (MES-23.5) via distinct G proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10024542&form=6&db=m Role of antibodies against Bordetella pertussis virulence factors in adherence of Bordetella pertussis and Bordetella parapertussis to human bronchial epithelial cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10024543&form=6&db=m Role of Bordetella pertussis virulence factors in adherence to epithelial cell lines derived from the human respiratory tract. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10024603&form=6&db=m Surface expression of a protective recombinant pertussis toxin S1 subunit fragment in Streptococcus gordonii. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10026821&form=6&db=m Vasopressin regulates adrenal functions by acting through different vasopressin receptor subtypes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10027833&form=6&db=m Comparison of functional antagonism between isoproterenol and M2 muscarinic receptors in guinea pig ileum and trachea. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10027852&form=6&db=m Development of muscarinic analgesics derived from epibatidine: role of the M4 receptor subtype. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10027878&form=6&db=m The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10028933&form=6&db=m Mechanism of endothelial nitric oxide-dependent vasorelaxation induced by wine polyphenols in rat thoracic aorta. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10029206&form=6&db=m Role of protein kinase C in ethanol-induced activation of adenylyl cyclase. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10029579&form=6&db=m Phenotypic and functional evidence for the expression of CXCR4 receptor during megakaryocytopoiesis. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10030845&form=6&db=m Pertussis toxin-induced lung edema. Role of manganese superoxide dismutase and protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10037491&form=6&db=m Amyloid beta protein (25-35) phosphorylates MARCKS through tyrosine kinase-activated protein kinase C signaling pathway in microglia. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10048787&form=6&db=m Interferon-gamma elicits a G-protein-dependent Ca2+ signal in human neutrophils after depletion of intracellular Ca2+ stores. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10050772&form=6&db=m Somatostatin induces hyperpolarization in pancreatic islet alpha cells by activating a G protein-gated K+ channel. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051153&form=6&db=m Mechanisms involved in the metabotropic glutamate receptor-enhancement of NMDA-mediated motoneurone responses in frog spinal cord. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051215&form=6&db=m Alpha2-adrenoceptor-mediated enhancement of glycine response in rat sacral dorsal commissural neurons. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051431&form=6&db=m Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051434&form=6&db=m Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kinase and phosphoinositide 3-kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051533&form=6&db=m Identification and characterization of multiple subtypes of muscarinic acetylcholine receptors and their physiological functions in canine hearts. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051542&form=6&db=m G protein activation by human dopamine D3 receptors in high-expressing Chinese hamster ovary cells: A guanosine-5'-O-(3-[35S]thio)- triphosphate binding and antibody study. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051767&form=6&db=m mGluR7-like metabotropic glutamate receptors inhibit NMDA-mediated excitotoxicity in cultured mouse cerebellar granule neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051770&form=6&db=m Anandamide and WIN 55212-2 inhibit cyclic AMP formation through G-protein-coupled receptors distinct from CB1 cannabinoid receptors in cultured astrocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10064216&form=6&db=m Incidence of pertussis infection in healthcare workers. diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10065161&form=6&db=m Insulin activates G alpha il,2 protein in rat hepatoma (HTC) cell membranes. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10066418&form=6&db=m G protein-mediated mitogen-activated protein kinase activation by two dopamine D2 receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10066449&form=6&db=m Threshold-dependent DNA synthesis by pure pressure in human aortic smooth muscle cells: Gialpha-dependent and -independent pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10066679&form=6&db=m Proadrenomedullin N-terminal 20 peptide hyperpolarizes the membrane by activating an inwardly rectifying K+ current in differentiated PC12 cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10066680&form=6&db=m Mechanical stimulation regulates voltage-gated potassium currents in cardiac microvascular endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10066893&form=6&db=m Selective activation of heterologously expressed G protein-gated K+ channels by M2 muscarinic receptors in rat sympathetic neurones. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10066923&form=6&db=m Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10067836&form=6&db=m Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10067847&form=6&db=m Growth hormone and dexamethasone stimulate lipolysis and activate adenylyl cyclase in rat adipocytes by selectively shifting Gi alpha2 to lower density membrane fractions. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10067866&form=6&db=m Raf-1 kinase activation by angiotensin II in adrenal glomerulosa cells: roles of Gi, phosphatidylinositol 3-kinase, and Ca2+ influx. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10069501&form=6&db=m Contractile role of M2 and M3 muscarinic receptors in gastrointestinal smooth muscle. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10069508&form=6&db=m Role of M2 muscarinic receptors in airway smooth muscle contraction. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10072549&form=6&db=m Endogenous platelet-activating factor is critically involved in effector functions of eosinophils stimulated with IL-5 or IgG. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10074122&form=6&db=m Identification of CXCR4 domains that support coreceptor and chemokine receptor functions. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10075696&form=6&db=m KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10079202&form=6&db=m Human immunodeficiency virus-1 infection requires pertussis toxin sensitive G-protein-coupled signalling and mediates cAMP downregulation. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10081751&form=6&db=m A signaling pathway for stimulation of Na+ uptake induced by angiotensin II in primary cultured rabbit renal proximal tubule cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10082268&form=6&db=m Pertussis toxin increases isoproterenol induced relaxation in field-stimulated ileum. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10082273&form=6&db=m Inhibition by fluoxetine of voltage-activated ion channels in rat PC12 cells. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10082885&form=6&db=m Modulation of the neuronal nicotinic acetylcholine receptor-channel by the nootropic drug nefiracetam. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10084330&form=6&db=m Simultaneous amplification of Bordetella repeated insertion sequences and toxin promoter region gene by polymerase chain reaction. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10085089&form=6&db=m The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10085221&form=6&db=m Gi-mediated tyrosine phosphorylation of Grb2 (growth-factor-receptor-bound protein 2)-bound dynamin-II by lysophosphatidic acid. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10085357&form=6&db=m Metabotropic glutamate receptor modulation of glutamate responses in the suprachiasmatic nucleus. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10085462&form=6&db=m New actions of melatonin on tumor metabolism and growth. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10086997&form=6&db=m Prostaglandin E-prostanoid-3 receptor activation of cyclic AMP response element-mediated gene transcription. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10087033&form=6&db=m Antinociceptive properties of the new alkaloid, cis-8, 10-di-N-propyllobelidiol hydrochloride dihydrate isolated from Siphocampylus verticillatus: evidence for the mechanism of action. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10087039&form=6&db=m Muscarinic M3 receptor inactivation reveals a pertussis toxin-sensitive contractile response in the guinea pig colon: evidence for M2/M3 receptor interactions. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10087139&form=6&db=m On the mechanism of the enhancement of delayed rectifier K+ current by extracellular ATP in guinea-pig ventricular myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10087153&form=6&db=m ATP acting on P2Y receptors triggers calcium mobilization in primary cultures of rat neurohypophysial astrocytes (pituicytes). therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10087453&form=6&db=m Inhibition of hormonally induced inositol trisphosphate production in Transfected GH4C1 cells: A novel role for the D5 subtype of the dopamine receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10089562&form=6&db=m Effects of intrapancreatic neuronal activation on cholecystokinin-induced exocrine secretion of isolated perfused rat pancreas. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10089567&form=6&db=m The effects of interfering with GTP-binding proteins on the activation mechanism of calcium release-activated calcium current. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10090417&form=6&db=m Calcium signaling induced by angiotensin II in the pancreatic acinar cell line AR42J. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10092093&form=6&db=m Mechanisms of IL-8-induced Ca2+ signaling in human neutrophil granulocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10092104&form=6&db=m Isolation and characterization of natural human IgG with a morphine-like activity. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10092597&form=6&db=m Distinct roles for Galphai2, Galphai3, and Gbeta gamma in modulation offorskolin- or Gs-mediated cAMP accumulation and calcium mobilization by dopamine D2S receptors. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10092665&form=6&db=m Both Gs and Gi proteins are critically involved in isoproterenol-induced cardiomyocyte hypertrophy. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10092776&form=6&db=m Recruitment of pleckstrin and phosphoinositide 3-kinase gamma into the cell membranes, and their association with G beta gamma after activation of NK cells with chemokines. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10092867&form=6&db=m Pertussis toxin-sensitive and insensitive intracellular signalling pathways in undifferentiated 3T3-L1 cells stimulated by insulin converge with phosphatidylinositol 3-kinase upstream of the Ras mitogen-activated protein kinase cascade. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10094497&form=6&db=m Expression and a role of functionally coupled P2Y receptors in human dendritic cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10095022&form=6&db=m Inositol-1,4,5-trisphosphate accumulation induced by urinary pheromones in female rat vomeronasal epithelium. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10095077&form=6&db=m Molecular pathways mediating activation by kainate of mitogen-activated protein kinase in oligodendrocyte progenitors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10095857&form=6&db=m Thimerosal-induced Ca2+ mobilization in isolated guinea pig cochlear outer hair cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10098495&form=6&db=m Roles of Gi and Gq/11 in mediating desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10098498&form=6&db=m Signal transduction of arginine vasopressin-induced arachidonic acid release in H9c2 cardiac myoblasts: role of Ca2+ and the protein kinase C-dependent activation of p42 mitogen-activated protein kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10098853&form=6&db=m Agonist stimulation of the serotonin1A receptor causes suppression of anoxia-induced apoptosis via mitogen-activated protein kinase in neuronal HN2-5 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10098887&form=6&db=m The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10100483&form=6&db=m Evidence for the role of heterotrimeric guanine nucleotide-binding regulatory proteins in the regulation of the mouse sperm adenylyl cyclase by the egg's zona pellucida. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10100738&form=6&db=m Melatonin receptor potentiation of cyclic AMP and the cystic fibrosis transmembrane conductance regulator ion channel. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10100885&form=6&db=m Ca2+-independent synergistic augmentation of O2- production by FMLP and PMA in HL-60 cells. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10101223&form=6&db=m Interleukin-8: An autocrine inflammatory mediator. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10101261&form=6&db=m Differential potentiation of arachidonic acid release by rat alpha2 adrenergic receptor subtypes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10102794&form=6&db=m Neurotensin stimulation of mast cell secretion is receptor-mediated, pertussis-toxin sensitive and requires activation of phospholipase C. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10188800&form=6&db=m Functional role of M2 muscarinic receptors in the guinea pig ileum. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10188801&form=6&db=m Bimodal regulation of cyclic AMP by muscarinic receptors. Involvement of multiple G proteins and different forms of adenylyl cyclase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10188803&form=6&db=m Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10188947&form=6&db=m Mu-opioid agonist-induced activation of G-protein-coupled inwardly rectifying potassium current in rat periaqueductal gray neurons. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10188976&form=6&db=m GABA(B) receptor-mediated stimulation of adenylyl cyclase activity in membranes of rat olfactory bulb. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10188995&form=6&db=m Signalling by CXC-chemokine receptors 1 and 2 expressed in CHO cells: a comparison of calcium mobilization, inhibition of adenylyl cyclase and stimulation of GTPgammaS binding induced by IL-8 and GROalpha. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10190131&form=6&db=m [Facilitatory actions of the cognitive enhancer nefiracetam on neuronal Ca2+ channels and nicotinic ACh receptors: their intracellular signal transduction pathways] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10190139&form=6&db=m [A molecular mechanism for supersensitization of adenylyl cyclase system in cloned opioid receptor-transfected cells following sustained opioid treatment] therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10190149&form=6&db=m [The involvement of muscarinic M1 receptor in the regulation of action potentials in mouse isolated right atria] ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10191209&form=6&db=m Cytomegalovirus induction of interleukin-6 in lung fibroblasts occurs independently of active infection and involves a G protein and the transcription factor, NF-kappaB. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10191313&form=6&db=m AMPA receptor activates a G-protein that suppresses a cGMP-gated current. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10191507&form=6&db=m Effect of Aspergillus terreus mycotoxins on nitric oxide synthase activity in human erythroid K-562 cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10192172&form=6&db=m Effects of UTP on Na+, Cl- and K+ transport in primary cultures from human sweat gland coils. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10193774&form=6&db=m G-protein activation by putative antagonists at mutant Thr373Lys alpha2A adrenergic receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10193782&form=6&db=m Dual coupling of heterologously-expressed rat P2Y6 nucleotide receptors to N-type Ca2+ and M-type K+ currents in rat sympathetic neurones. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10193786&form=6&db=m Cell-specific coupling of PGE2 to different transduction pathways in arginine vasopressin- and glucagon-sensitive segments of the rat renal tubule. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10194077&form=6&db=m Serum IgG antibody responses to pertussis toxin and filamentous hemagglutinin in nonvaccinated and vaccinated children and adults with pertussis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,1,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10194078&form=6&db=m Serum IgG antibody response to pertussis toxin in persons for whom pertussis vaccination failed depends upon the number of antigens in the vaccine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10196148&form=6&db=m Porcine pancreatic phospholipase A2 stimulates secretin release from secretin-producing cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10196164&form=6&db=m Miniglucagon (glucagon 19-29), a potent and efficient inhibitor of secretagogue-induced insulin release through a Ca2+ pathway. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10196234&form=6&db=m Pro-adhesive and chemotactic activities of thrombospondin-1 for breast carcinoma cells are mediated by alpha3beta1 integrin and regulated by insulin-like growth factor-1 and CD98. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10198193&form=6&db=m Effects of endothelin-1 on Ca2+ signaling in guinea-pig ventricular myocytes: role of protein kinase C. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10198345&form=6&db=m 1,25-dihydroxyvitamin D3 but not TPA activates PLD in Caco-2 cells via pp60(c-src) and RhoA. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10201000&form=6&db=m Lipoprotein(a) stimulates growth of human mesangial cells and induces activation of phospholipase C via pertussis toxin-sensitive G proteins. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10201643&form=6&db=m Both dopamine and the putative dopamine D3 receptor antagonist PNU-99194A induce a biphasic inhibition of phorbol ester-stimulated arachidonic acid release from CHO cells transfected with the dopamine D3 receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10205011&form=6&db=m Role of potassium channels in the antinociception induced by agonists of alpha2-adrenoceptors. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10205012&form=6&db=m Activation of adenylate cyclase by human recombinant sst5 receptors expressed in CHO-K1 cells and involvement of Galphas proteins. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10205014&form=6&db=m The putative melatonin receptor antagonist GR128107 is a partial agonist on Xenopus laevis melanophores. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10205151&form=6&db=m Activation of p38 mitogen-activated protein kinase by oxidized LDL in vascular smooth muscle cells: mediation via pertussis toxin-sensitive G proteins and association with oxidized LDL-induced cytotoxicity. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10206134&form=6&db=m Adverse effects and sero-responses to an acellular pertussis/diphtheria/tetanus vaccine when combined with Haemophilus influenzae type b vaccine in an accelerated schedule. diagnostic usage,ongoing research,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10207024&form=6&db=m The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10207034&form=6&db=m U50,488H-induced internalization of the human kappa opioid receptor involves a beta-arrestin- and dynamin-dependent mechanism. Kappa receptor internalization is not required for mitogen-activated protein kinase activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10209304&form=6&db=m Angiotensin II-mediated signal transduction events in cystic fibrosis pancreatic duct cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10212213&form=6&db=m Fyn kinase-directed activation of SH2 domain-containing protein-tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in Madin-Darby canine kidney cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10212240&form=6&db=m CC chemokine receptor-3 undergoes prolonged ligand-induced internalization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10213074&form=6&db=m Effects of T-588, a novel cognitive enhancer, on ADP-ribosylation of G(s alpha) by cholera toxin and cyclic AMP accumulation in rat cerebral cortex. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10215674&form=6&db=m Determination of [35S]guanosine-5'-O-(3-thio)triphosphate binding mediated by cholinergic muscarinic receptors in membranes from Chinese hamster ovary cells and rat striatum using an anti-G protein scintillation proximity assay. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10217281&form=6&db=m Involvement of the carboxyl terminus of the third intracellular loop of the cannabinoid CB1 receptor in constitutive activation of Gs. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10217358&form=6&db=m High-density lipoprotein increases intracellular calcium levels by releasing calcium from internal stores in human endothelial cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10217527&form=6&db=m Bradykinin-induced phosphoinositide hydrolysis and Ca2+ mobilization in canine cultured tracheal epithelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10218491&form=6&db=m Stimulation of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocytic cell line HL60. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10218646&form=6&db=m Stimulation of respiratory burst by cyclocommunin in rat neutrophils is associated with the increase in cellular Ca2+ and protein kinase C activity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10218868&form=6&db=m Endomorphin-1 potentiates HIV-1 expression in human brain cell cultures: implication of an atypical mu-opioid receptor. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10218903&form=6&db=m Differential cholera-toxin sensitivity of supraspinal antinociception induced by the cannabinoid agonists delta9-THC, WIN 55,212-2 and anandamide in mice. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10218977&form=6&db=m The role of protein kinases A and C pathways in the regulation of mitogen-activated protein kinase activation in response to gonadotropin-releasing hormone receptor activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10219628&form=6&db=m Ontogeny of pulmonary neuroendocrine cells which express the alpha-subunit of guanine nucleotide-binding protein Go. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10219978&form=6&db=m Effects of lithium on receptor-mediated activation of G proteins in rat brain cortical membranes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10219983&form=6&db=m Characterisation of the fish sst3 receptor, a member of the SRIF1 receptor family: atypical pharmacological features. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10220556&form=6&db=m Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10223691&form=6&db=m A ten year follow-up after immunization with a two component acellular pertussis vaccine. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10223692&form=6&db=m Cell-mediated immune responses to antigens of Bordetella pertussis and protection against pertussis in school children. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10224076&form=6&db=m Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10224146&form=6&db=m Thrombin induces proteinase-activated receptor-1 gene expression in endothelial cells via activation of Gi-linked Ras/mitogen-activated protein kinase pathway. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10225291&form=6&db=m Development of neutralising human recombinant antibodies to pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10225429&form=6&db=m Cannabinoid receptor CB1 activates the Na+/H+ exchanger NHE-1 isoform via Gi-mediated mitogen activated protein kinase signaling transduction pathways. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10229118&form=6&db=m Characterization of membrane melatonin receptor in mouse peritoneal macrophages: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10229836&form=6&db=m Pertussis toxin-sensitive signal controls the trafficking of thymocytes across the corticomedullary junction in the thymus. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10230801&form=6&db=m Expression of RGS2 alters the coupling of metabotropic glutamate receptor 1a to M-type K+ and N-type Ca2+ channels. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10230818&form=6&db=m Lysophosphatidylcholine induces changes in physicochemical, morphological, and functional properties of mouse zona pellucida: a possible role of phospholipase A2 in sperm-zona pellucida interaction. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10231369&form=6&db=m Protein kinase C antagonizes pertussis-toxin-sensitive coupling of the calcitonin receptor to adenylyl cyclase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10233875&form=6&db=m NF-kappaB activation is required for C5a-induced interleukin-8 gene expression in mononuclear cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10320562&form=6&db=m Effects of TGF-beta1 on prolactin synthesis and secretion: an in-vitro study. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10323308&form=6&db=m Activation of various G-protein coupled receptors modulates Ca2+ channel currents via PTX-sensitive and voltage-dependent pathways in rat intracardiac neurons. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10323588&form=6&db=m Relationship between NaF- and thapsigargin-induced endothelium-dependent hyperpolarization in rat mesenteric artery. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10323591&form=6&db=m Anandamide-induced mobilization of cytosolic Ca2+ in endothelial cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10323600&form=6&db=m P2Y receptor-mediated Ca2+ signalling in cultured rat aortic smooth muscle cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10325964&form=6&db=m P2 purinoceptors contribute to ATP-induced inhibition of L-type Ca2+ current in rabbit atrial myocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10329469&form=6&db=m Sphingosylphosphorylcholine activates Gq, Gi-2, and Gi-3 in thyroid FRTL-5 cells: implications for the activation of calcium fluxes and Na+-H+ exchange. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10329832&form=6&db=m Pharmacologic regulation of histamine release by the human recombinant histamine-releasing factor. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10330225&form=6&db=m Adenosine A2a-receptor activation enhances cardiomyocyte shortening via Ca2+-independent and -dependent mechanisms. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10331419&form=6&db=m Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10331497&form=6&db=m MCP-1 is selectively expressed in the late phase by cytokine-stimulated human neutrophils: TNF-alpha plays a role in maximal MCP-1 mRNA expression. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10332086&form=6&db=m New roles for RGS2, 5 and 8 on the ratio-dependent modulation of recombinant GIRK channels expressed in Xenopus oocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10334887&form=6&db=m Functional characterization of alpha1-adrenergic receptors in experimental vein grafts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10336439&form=6&db=m Synergism among lysophosphatidic acid, beta1A integrins, and epidermal growth factor or platelet-derived growth factor in mediation of cell migration. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10336519&form=6&db=m Ethanol enhances basal and flow-stimulated nitric oxide synthase activity in vitro by activating an inhibitory guanine nucleotide binding protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10336565&form=6&db=m Gi-mediated activation of mitogen-activated protein kinase (MAPK) pathway by receptor mimetic basic secretagogues of connective tissue-type mast cells: bifurcation of arachidonic acid-induced release upstream of MAPK. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10336674&form=6&db=m Stimulation of mu- and delta-opioid receptors enhances phosphoinositide metabolism in mouse spinal cord: evidence for subtypes of delta-receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10336676&form=6&db=m Activation of the extracellular signal-regulated kinase 2 by metabotropic glutamate receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10336847&form=6&db=m Activation of a beta-adrenergic-sensitive signal transduction pathway by the secosteroid hormone 1,25-(OH)2-vitamin D3 in chick heart. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10338531&form=6&db=m Variation in the Bordetella pertussis virulence factors pertussis toxin and pertactin in vaccine strains and clinical isolates in Finland. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10340380&form=6&db=m Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10340411&form=6&db=m Marrow engraftment of hematopoietic stem and progenitor cells is independent of Galphai-coupled chemokine receptors. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10340723&form=6&db=m Melatonin receptors in PC3 human prostate tumor cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10340944&form=6&db=m Characterization of the integrin and activation steps mediating human eosinophil and neutrophil adhesion to chronically inflamed airway endothelium. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10342794&form=6&db=m Lysophosphatidic acid stimulates protein kinase C isoforms alpha, beta, epsilon, and zeta in a pertussis toxin sensitive pathway in vascular smooth muscle cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10344528&form=6&db=m G protein coupling of CGS 21680 binding sites in the rat hippocampus and cortex is different from that of adenosine A1 and striatal A2A receptors. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10347203&form=6&db=m Activated G protein-coupled receptor induces tyrosine phosphorylation of STAT3 and agonist-selective serine phosphorylation via sustained stimulation of mitogen-activated protein kinase. Resultant effects on cell proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10349852&form=6&db=m Expression of cytokines by human astrocytomas following stimulation by C3a and C5a anaphylatoxins: specific increase in interleukin-6 mRNA expression. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10352101&form=6&db=m Steady and transient fluid shear stress stimulate NO release in osteoblasts through distinct biochemical pathways. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10358036&form=6&db=m Activation of the de novo biosynthesis of sphingolipids mediates angiotensin II type 2 receptor-induced apoptosis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10358189&form=6&db=m Purine metabolites suppress proliferation of human NK cells through a lineage-specific purine receptor. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10358194&form=6&db=m Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10359582&form=6&db=m Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes, and T cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10362672&form=6&db=m Activation of Akt/protein kinase B after stimulation with angiotensin II in vascular smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10362691&form=6&db=m Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10364208&form=6&db=m Alternate coupling of receptors to Gs and Gi in pancreatic and submandibular gland cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10364257&form=6&db=m Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophils. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10370056&form=6&db=m Lack of involvement of G proteins in the activation of cardiac CFTR Cl- current by genistein. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10370090&form=6&db=m Use of replication-deficient adenoviruses to study signal transduction pathways. Muscarinic responses in HSG and HT29 epithelial cell lines are mediated by G protein betagamma-subunits. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10371171&form=6&db=m The implication of the chemokine receptor CXCR4 in HIV-1 envelope protein-induced apoptosis is independent of the G protein-mediated signalling. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10371205&form=6&db=m Antisense oligonucleotides against receptor kinase GRK2 disrupt target selectivity of beta-adrenergic receptors in atrial myocytes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10371694&form=6&db=m Desensitization of cardiac beta-adrenoceptor signaling with heart failure produced by myocardial infarction in the rat. Evidence for the role of Gi but not Gs or phosphorylating proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10372655&form=6&db=m The priming effect of 12(S)-hydroxyeicosatetraenoic acid on lymphocyte phospholipase D involves specific binding sites. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10372804&form=6&db=m Involvement of intermediary metabolites in the pathway of extracellular Ca2+-induced mitogen-activated protein kinase activation in human fibroblasts. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10372805&form=6&db=m Signalling events mediating the activation of protein kinase C by interleukin-2 in cytotoxic T cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10373686&form=6&db=m betagamma dimers derived from Go and Gi proteins contribute different components of adrenergic inhibition of Ca2+ channels in rat sympathetic neurones. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10374721&form=6&db=m Functional alpha2C-adrenoceptors in human neuroblastoma SH-SY5Y cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10375012&form=6&db=m Inhibition of protein phosphatase 2A (PP2A) mimics suckling-induced sensitization of mammotropes: involvement of a pertussis toxin (PTX) sensitive G-protein and the adenylate cyclase (AC). ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10375750&form=6&db=m Involvement of a putative G-protein-coupled receptor and a branching pathway in argipressin (4-8) signal transduction in rat hippocampus. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10376806&form=6&db=m Coupling of beta-adrenergic receptors to cardiac L-type Ca2+ channels: preferential coupling of the beta1 versus beta2 receptor subtype and evidence for PKA-independent activation of the channel. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10376808&form=6&db=m Assessment of the extracellular and intracellular actions of sphingosine 1-phosphate by using the p42/p44 mitogen-activated protein kinase cascade as a model. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10376810&form=6&db=m 5-Hydroxytryptamine-induced phosphoinositide hydrolysis and Ca2+ mobilisation in canine cultured aorta smooth muscle cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10376935&form=6&db=m Delta opioid receptors expressed by stably transfected jurkat cells signal through the map kinase pathway in a ras-independent manner. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10376953&form=6&db=m Induction of experimental autoimmune neuritis in CD4-8-C57BL/6J mice. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10379613&form=6&db=m Effects of systemically applied allopurinol and prednisolone on experimental autoimmune uveitis. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10381350&form=6&db=m Secretory phospholipase A2 induces phospholipase Cgamma-1 activation and Ca2+ mobilization in the human astrocytoma cell line 1321N1 by a mechanism independent of its catalytic activity. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10381367&form=6&db=m EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10381645&form=6&db=m ATP and adenosine prevent via different pathways the activation of caspases in apoptotic AKR-2B fibroblasts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10383051&form=6&db=m Endothelin-induced protein tyrosine phosphorylation of cultured astrocytes: its relationship to cytoskeletal actin organization. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10383439&form=6&db=m Receptor-mediated internalization is critical for the inhibition of the expression of growth hormone by somatostatin in the pituitary cell line AtT-20. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10384262&form=6&db=m Adenylyl cyclase interaction with the D2 dopamine receptor family; differential coupling to Gi, Gz, and Gs. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10385259&form=6&db=m Expression of P2Y receptors in cell lines derived from the human lung. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10385412&form=6&db=m Regulation of alkaline phosphatase activity by p38 MAP kinase in response to activation of Gi protein-coupled receptors by epinephrine in osteoblast-like cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10386237&form=6&db=m Pertussis toxin-sensitive G-proteins and regulation of blood pressure in the spontaneously hypertensive rat. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10391179&form=6&db=m Treatment of severe pertussis: a study of the safety and pharmacology of intravenous pertussis immunoglobulin. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10391844&form=6&db=m Protective effects of pertussis immunoglobulin (P-IGIV) in the aerosol challenge model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10391918&form=6&db=m Regulation of Ras.GTP loading and Ras-Raf association in neonatal rat ventricular myocytes by G protein-coupled receptor agonists and phorbol ester. Activation of the extracellular signal-regulated kinase cascade by phorbol ester is mediated by Ras. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10391942&form=6&db=m Angiotensin II negatively modulates L-type calcium channels through a pertussis toxin-sensitive G protein in adrenal glomerulosa cells. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10391949&form=6&db=m Gi proteins use a novel beta gamma- and Ras-independent pathway to activate extracellular signal-regulated kinase and mobilize AP-1 transcription factors in Jurkat T lymphocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10393971&form=6&db=m Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10394531&form=6&db=m G-protein regulation of the solubilized human zona pellucida-mediated acrosome reaction and zona pellucida binding. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10395691&form=6&db=m Neutrophil defensins induce histamine secretion from mast cells: mechanisms of action. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10395694&form=6&db=m Chemotaxis of rat mast cells toward adenine nucleotides. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10395958&form=6&db=m Perinatal PTX-sensitive G-protein expression and regulation of conductive 22Na+ transport in lung apical membrane vesicles. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10397732&form=6&db=m Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10398422&form=6&db=m Modulation of adenylyl cyclase by FPP and adenosine involves stimulatory and inhibitory adenosine receptors and g proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10398877&form=6&db=m Opioid potentiation of N-type Ca2+ channel currents via pertussis-toxin-sensitive G proteins in NG108-15 cells. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10400084&form=6&db=m Selective coupling of mouse brain metabotropic sigma receptor with recombinant Gi1. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10400226&form=6&db=m Supersensitization of the adenylyl cyclase system in Chinese hamster ovary cells co-expressing cloned opioid receptors and Gz, a PTX-insensitive G protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10400312&form=6&db=m Signal pathway of mitogen-induced Ca2+-activated K+ currents in young and aged T-cell clones of C57BL/6 mice. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10400938&form=6&db=m GABAB receptor-mediated regulation of glutamate-activated calcium transients in hypothalamic and cortical neuron development. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10401562&form=6&db=m Human P2Y2 receptor polymorphism: identification and pharmacological characterization of two allelic variants. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10401667&form=6&db=m An adenosine receptor agonist-induced modulation of TSH-dependent cell growth in FRTL-5 thyroid cells mediated by inhibitory G protein, Gi. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10402434&form=6&db=m The presence of a heterotrimeric G protein and its role in signal transduction of extracellular calmodulin in pollen germination and tube growth diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10405760&form=6&db=m Identification of distinct signalling pathways for somatostatin receptors SSTR1 and SSTR2 as revealed by microphysiometry. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10407016&form=6&db=m kappa-Opioid tolerance and dependence in cultures of dopaminergic midbrain neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10407026&form=6&db=m Ca(2+)-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10408379&form=6&db=m Tyrosine phosphorylation and activation of Janus kinase 1 and STAT3 by sublytic C5b-9 complement complex in aortic endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10408834&form=6&db=m FMLP- and TNF-stimulated monoclonal Lym-1 antibody-dependent lysis of B lymphoblastoid tumour targets by neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10411608&form=6&db=m Comparison of the ligand binding and signaling properties of human dopamine D(2) and D(3) receptors in Chinese hamster ovary cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10411794&form=6&db=m Oxytocin activates mitogen-activated protein kinase and up-regulates cyclooxygenase-2 and prostaglandin production in human myometrial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10413116&form=6&db=m Examination of the signal transduction pathways leading to activation of extracellular signal-regulated kinase by formyl-methionyl-leucyl-phenylalanine in rat neutrophils. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10415069&form=6&db=m Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10418915&form=6&db=m Intranasal murine model of Bordetella pertussis infection: II. Sequence variation and protection induced by a tricomponent acellular vaccine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419530&form=6&db=m Melatonin promotes osteoblast differentiation and bone formation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419531&form=6&db=m G(i) protein-mediated functional compartmentalization of cardiac beta(2)-adrenergic signaling. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419564&form=6&db=m Kainate receptors coupled to G(i)/G(o) proteins in the rat hippocampus. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10421041&form=6&db=m Evaluation of a single-sample serological technique for diagnosing pertussis in unvaccinated children. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10425192&form=6&db=m Differential regulation of 46 and 54 kDa jun N-terminal kinases and p38 mitogen-activated protein kinase by human alpha(1A)-adrenoceptors expressed in Rat-1 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10428051&form=6&db=m Regulation of transmembrane signaling by ganglioside GM1: interaction of anti-GM1 with Neuro2a cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10428422&form=6&db=m Modulation of 5-HT1A receptor signalling by point-mutation of cysteine351 in the rat Galpha(o) protein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10428859&form=6&db=m Cooperation between thrombospondin-1 type 1 repeat peptides and alpha(v)beta(3) integrin ligands to promote melanoma cell spreading and focal adhesion kinase phosphorylation. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10429189&form=6&db=m Adenosine inhibits the renal plasma-membrane (Ca2+ + Mg2+)-ATPase through a pathway sensitive to cholera toxin and sphingosine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10430180&form=6&db=m Mechanisms contributing to fluid-flow-induced Ca2+ mobilization in articular chondrocytes. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10431764&form=6&db=m Effect of NMDA receptor ligands on mast cell histamine release, a reappraisal. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10432304&form=6&db=m Endothelin-1 activates p38 mitogen-activated protein kinase and cytosolic phospholipase A2 in cat iris sphincter smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10433494&form=6&db=m The effect of site-directed mutagenesis of two transmembrane serine residues on agonist-specific coupling of a cloned human alpha2A-adrenoceptor to adenylyl cyclase. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10433503&form=6&db=m Characterization of beta-adrenoceptor mediated smooth muscle relaxation and the detection of mRNA for beta1-, beta2- and beta3-adrenoceptors in rat ileum. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10433511&form=6&db=m Inhibition of GTPase activity of Gi proteins and decreased agonist affinity at M2 muscarinic acetylcholine receptors by spermine and methoctramine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10433521&form=6&db=m Activation of the Ras-GRF/CDC25Mm exchange factor by lysophosphatidic acid. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10435003&form=6&db=m Modulation of the pacemaker current If by beta-adrenoceptor subtypes in ventricular myocytes isolated from hypertensive and normotensive rats. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10436038&form=6&db=m Biphasic, opposing modulation of cloned neuronal alpha1E Ca channels by distinct signaling pathways coupled to M2 muscarinic acetylcholine receptors. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10436392&form=6&db=m Pertussis adjuvant prolongs intestinal hypersensitivity. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10438359&form=6&db=m Vaccination with pertussis toxin alters the antibody response to simultaneous respiratory syncytial virus challenge. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10443507&form=6&db=m The protective effect of immunisation against diphtheria, pertussis and tetanus (DPT) in relation to sudden infant death syndrome. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10443914&form=6&db=m Nitroxide stable radical suppresses autoimmune uveitis in rats. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10444182&form=6&db=m SDF-1 suppresses cytokine-induced adhesion of human haemopoietic progenitor cells to immobilized fibronectin. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10444497&form=6&db=m Opioid modulation of calcium current in cultured sensory neurons: mu-modulation of baroreceptor input. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10445797&form=6&db=m Inhibitory guanine nucleotide regulatory protein activation of mitogen-activated protein kinase in experimental hepatocellular carcinoma in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10446064&form=6&db=m LDL stimulates mitogen-activated protein kinase phosphatase-1 expression, independent of LDL receptors, in vascular smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10446161&form=6&db=m Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10446204&form=6&db=m Prolonged activation of extracellular signal-regulated kinase by a protein kinase C-dependent and N17Ras-insensitive mechanism mediates the proliferative response of G(i/o)-coupled somatostatin sst(4) receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10447026&form=6&db=m Microbiological and serological diagnosis of pertussis. diagnostic usage,ongoing research,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10454146&form=6&db=m Lysophosphatidic acid-induced, pertussis toxin-sensitive nociception through a substance P release from peripheral nerve endings in mice. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10455189&form=6&db=m Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10455259&form=6&db=m Pharmacological characterization of extracellular acidification rate responses in human D2(long), D3 and D4.4 receptors expressed in Chinese hamster ovary cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10455315&form=6&db=m Evidence that the ATP-induced increase in vasomotion of guinea-pig mesenteric lymphatics involves an endothelium-dependent release of thromboxane A2. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10455874&form=6&db=m External support modulates G protein expression and receptor coupling in experimental vein grafts. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10457086&form=6&db=m Two different ionotropic receptors are activated by ATP in rat microglia. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10459768&form=6&db=m Pertussis toxin-sensitive G proteins as mediators of stretch-induced decrease in nitric-oxide release of osteoblast-like cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10460702&form=6&db=m 5-hydroxytryptamine evokes endothelial nitric oxide synthase activation in bovine aortic endothelial cell cultures. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10460925&form=6&db=m Parapertussis and pertussis: differences and similarities in incidence, clinical course, and antibody responses. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10462235&form=6&db=m An acellular pertussis vaccine in healthy adults: safety and immunogenicity. Pennridge Pediatric Associates. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10462553&form=6&db=m Influence of G protein type on agonist efficacy. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10462554&form=6&db=m Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10462712&form=6&db=m Galpha(q/11) and gbetagamma proteins and membrane signaling of calcitriol and estradiol. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10463173&form=6&db=m Antigenic variants in Bordetella pertussis strains isolated from vaccinated and unvaccinated children. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10463330&form=6&db=m The G protein beta3 subunit splice variant Gbeta3-s causes enhanced chemotaxis of human neutrophils in response to interleukin-8. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10466075&form=6&db=m Asiasari radix inhibits immunoglobulin E production on experimental models in vitro and in vivo. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10466555&form=6&db=m Nosocomial pertussis in healthcare workers from a pediatric emergency unit in France. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10466749&form=6&db=m Effect of lysophosphatidic acid on the ovum transport in mouse oviducts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10471359&form=6&db=m Galpha(i2), Galpha(i3)and Galpha(o) are all required for normal muscarinic inhibition of the cardiac calcium channels in nodal/atrial-like cultured cardiocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10471775&form=6&db=m Receptor-mediated activation of phospholipase D by sphingosine 1-phosphate in skeletal muscle C2C12 cells. A role for protein kinase C. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10473174&form=6&db=m Inhibition of immunoglobulin E production by Poncirus trifoliata fruit extract. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10473267&form=6&db=m Altered adenylyl cyclase responsiveness subsequent to point mutations of Asp 128 in the third transmembrane domain of the delta-opioid receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10473272&form=6&db=m GABA(B) receptor activation protects GABA(A) receptor from cyclic AMP-dependent down-regulation in rat cerebellar granule cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10475354&form=6&db=m Intravesical therapy with pertussis toxin before radical cystectomy in patients with bladder cancer: a Phase I study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10477127&form=6&db=m Bombesin induces a reduction of somatostatin inhibition of adenylyl cyclase activity, Gi function, and somatostatin receptors in rat exocrine pancreas. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10477545&form=6&db=m The B-oligomer of pertussis toxin deactivates CC chemokine receptor 5 and blocks entry of M-tropic HIV-1 strains. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10479676&form=6&db=m Expression of Ca(2+)-mobilizing endothelin(A) receptors and their role in the control of Ca(2+) influx and growth hormone secretion in pituitary somatotrophs. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10480605&form=6&db=m A defect late in stimulus-secretion coupling impairs insulin secretion in Goto-Kakizaki diabetic rats. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10481222&form=6&db=m Pyrimidine nucleotide-evoked inhibition of cyclic AMP accumulation in equine epithelial cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10484384&form=6&db=m Group I secreted PLA2 and arachidonic acid metabolites in the maintenance of cat LES tone. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10484474&form=6&db=m Actin reorganization in airway smooth muscle cells involves Gq and Gi-2 activation of Rho. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10484515&form=6&db=m Lysophosphatidylcholine activates mesangial cell PKC and MAP kinase by PLCgamma-1 and tyrosine kinase-Ras pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10484618&form=6&db=m Mechanism(s) of activation of secretory phospholipase A(2)s in mouse keratinocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10485337&form=6&db=m Calcitonin gene-related peptide receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+ signaling pathways. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10488069&form=6&db=m Differential phospholipase D activation by bradykinin and sphingosine 1-phosphate in NIH 3T3 fibroblasts overexpressing gelsolin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10488100&form=6&db=m Agonist-induced, G protein-dependent and -independent down-regulation of the mu opioid receptor. The receptor is a direct substrate for protein-tyrosine kinase. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10488122&form=6&db=m Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10488142&form=6&db=m Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10490889&form=6&db=m Role of adenosine A(1) receptors in modulating extracellular adenosine levels. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10490918&form=6&db=m Dose-related opposite modulation by nociceptin/orphanin FQ of substance P nociception in the nociceptors and spinal cord. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10490921&form=6&db=m Angiotensin II-induced renal vasoconstriction in genetic hypertension. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10493334&form=6&db=m Safety and immunogenicity of heptavalent pneumococcal CRM197 conjugate vaccine in infants and toddlers. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10493336&form=6&db=m Comparison of a fifth dose of a five-component acellular or a whole cell pertussis vaccine in children four to six years of age. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10493527&form=6&db=m Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10493533&form=6&db=m Dual mechanisms for lysophospholipid induction of proliferation of human breast carcinoma cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10493910&form=6&db=m Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10496883&form=6&db=m Humoral and cellular immune responses in mice immunized with recombinant Mycobacterium bovis Bacillus Calmette-Guérin producing a pertussis toxin-tetanus toxin hybrid protein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10496950&form=6&db=m Regulation of G protein activation and effector modulation by fusion proteins between the human 5-hydroxytryptamine(1A) receptor and the alpha subunit of G(i1): differences in receptor-constitutive activity imparted by single amino acid substitutions in G(i1)alpha. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10496952&form=6&db=m Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10497165&form=6&db=m Inositol 1,4,5-trisphosphate-independent Ca(2+) mobilization triggered by a lipid factor isolated from vitreous body. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10497238&form=6&db=m The proximal portion of the COOH terminus of the oxytocin receptor is required for coupling to g(q), but not g(i). Independent mechanisms for elevating intracellular calcium concentrations from intracellular stores. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10497906&form=6&db=m Effects of kappa- and mu-opioid receptor agonists on Ca2+ channels in neuroblastoma cells: involvement of the orphan opioid receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10497911&form=6&db=m The effect of C-terminal truncation of the recombinant delta-opioid receptor on Ca2+i signaling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10498819&form=6&db=m Pleiotropic effects of lysophosphatidic acid on striatal astrocytes. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10499367&form=6&db=m The involvement of K+ channels and Gi/o protein in the antinociceptive action of the gallic acid ethyl ester. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10499523&form=6&db=m Endothelin-mediated vascular growth requires p42/p44 mitogen-activated protein kinase and p70 S6 kinase cascades via transactivation of epidermal growth factor receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10499524&form=6&db=m Bradykinin receptor localization and cell signaling pathways used by bradykinin in the regulation of gonadotropin-releasing hormone secretion. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10499871&form=6&db=m Positive inotropism induced by androgens in isolated left atrium of rat: evidence for a cAMP-dependent transcriptional mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10501179&form=6&db=m Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10501195&form=6&db=m Endogenous delta-opioid and ORL1 receptors couple to phosphorylation and activation of p38 MAPK in NG108-15 cells and this is regulated by protein kinase A and protein kinase C. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10506408&form=6&db=m Genetically derived toxoids for use as vaccines and adjuvants. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10506488&form=6&db=m cAMP-independent dilation of coronary arterioles to adenosine : role of nitric oxide, G proteins, and K(ATP) channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10507694&form=6&db=m Heterologous expression of a green fluorescent protein-pertussis toxin S1 subunit fusion construct disrupts calcium channel modulation in rat superior cervical ganglion neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10508918&form=6&db=m Somatostatin inhibits PDGF-stimulated Ras activation in human neuroblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10510311&form=6&db=m Activation of constitutive 5-hydroxytryptamine(1B) receptor by a series of mutations in the BBXXB motif: positioning of the third intracellular loop distal junction and its G(o)alpha protein interactions. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10511460&form=6&db=m Stem cell factor influences neuro-immune interactions: the response of mast cells to pituitary adenylate cyclase activating polypeptide is altered by stem cell factor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10512854&form=6&db=m Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10515187&form=6&db=m Calcitonin reverts pertussis toxin blockade of the opioid analgesia in mice. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10515879&form=6&db=m Fibronectin upregulates gelatinase B (MMP-9) and induces coordinated expression of gelatinase A (MMP-2) and its activator MT1-MMP (MMP-14) by human T lymphocyte cell lines. A process repressed through RAS/MAP kinase signaling pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10515959&form=6&db=m Vasopressin and amastatin induce V(1)-receptor-mediated suppression of excitatory transmission in the rat parabrachial nucleus. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10516171&form=6&db=m EP receptor-mediated inhibition by prostaglandin E(1) of cardiac L-type Ca(2+) current of rabbits. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10516296&form=6&db=m Cannabinoids enhance NMDA-elicited Ca2+ signals in cerebellar granule neurons in culture. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10516632&form=6&db=m Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10516638&form=6&db=m Cannabinoid CB1 receptors fail to cause relaxation, but couple via Gi/Go to the inhibition of adenylyl cyclase in carotid artery smooth muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10516961&form=6&db=m Pertussis toxin lesions of the rat substantia nigra block the inhibitory effects of the gamma-hydroxybutyrate agent, S(-)HA-966 without affecting the basal firing properties of dopamine neurons. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10518035&form=6&db=m Effects of CB(1) cannabinoid receptor activation on cerebellar granule cell nitric oxide synthase activity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10518754&form=6&db=m Mutants in the ptlA-H genes of Bordetella pertussis are deficient for pertussis toxin secretion. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10519139&form=6&db=m Mechanisms of the palmitoylcarnitine-induced response in vascular endothelial cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10521347&form=6&db=m Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10523045&form=6&db=m Interactions of lithium and drugs that affect signal transduction on behaviour in rats. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10523334&form=6&db=m Angiotensin II-stimulated induction of sis-inducing factor is mediated by pertussis toxin-insensitive G(q) proteins in cardiac myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10525114&form=6&db=m Cannabinoid receptors differentially modulate potassium A and D currents in hippocampal neurons in culture. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10525543&form=6&db=m Integrin-associated protein stimulates alpha2beta1-dependent chemotaxis via Gi-mediated inhibition of adenylate cyclase and extracellular-regulated kinases. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10526312&form=6&db=m Role of cdk5 and tau phosphorylation in heterotrimeric G protein-mediated retinal growth cone collapse. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10527563&form=6&db=m Induction of CD4(+) and CD8(+) Bordetella pertussis toxin subunit S1 specific T cells by immunization with synthetic peptides. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10528125&form=6&db=m Potentiation of transmitter release from NMB human neuroblastoma cells by kappa-opioids is mediated by N-type voltage-dependent calcium channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10528214&form=6&db=m Src-regulated extracellular signal-related kinase and Syk-regulated c-Jun N-terminal kinase pathways act in conjunction to induce IL-1 synthesis in response to microtubule disruption in HL60 cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10529404&form=6&db=m Secretory IgA-mediated basophil activation. II. Roles of GTP-binding regulatory proteins and phosphatidylinositol 3-kinase. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10530813&form=6&db=m Group 1 mGlu receptors elevate [Ca2+]i in rat cultured cortical type 2 astrocytes: [Ca2+]i synergy with adenosine A1 receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10531408&form=6&db=m Tight association of the human Mel(1a)-melatonin receptor and G(i): precoupling and constitutive activity. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10532586&form=6&db=m Lysophosphatidic acid as a regulator of endothelial/leukocyte interaction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10532953&form=6&db=m Diminished basal phosphorylation level of phospholamban in the postinfarction remodeled rat ventricle: role of beta-adrenergic pathway, G(i) protein, phosphodiesterase, and phosphatases. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10533043&form=6&db=m Metabotropic glutamate receptors modulate [(3)H]acetylcholine release from cultured amacrine-like neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10533046&form=6&db=m Pharmacological and molecular evidence for dopamine D(1) receptor expression by striatal astrocytes in culture. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10536119&form=6&db=m Inflammatory and contractile agents sensitize specific adenylyl cyclase isoforms in human airway smooth muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10537155&form=6&db=m The luteinizing hormone-releasing hormone receptor in human prostate cancer cells: messenger ribonucleic acid expression, molecular size, and signal transduction pathway. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10537288&form=6&db=m Role of mitogen-activated protein kinase/extracellular signal-regulated kinase cascade in gonadotropin-releasing hormone-induced growth inhibition of a human ovarian cancer cell line. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10537304&form=6&db=m Infiltration of tumors by systemically transferred tumor-reactive T lymphocytes is required for antitumor efficacy. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10543432&form=6&db=m Gq/11-coupled receptors and protein synthesis in rat cardiomyocytes: role of Gi-proteins and protein kinase C-isozymes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10544002&form=6&db=m Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10545129&form=6&db=m The action is at the terminal. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10545499&form=6&db=m Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10548476&form=6&db=m Light activation of phosphatidylethanolamine N-methyltransferase in rod outer segments and its modulation by association states of transducin. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10549650&form=6&db=m The requirement for pertussis to induce EAU is strain-dependent: B10.RIII, but not B10.A mice, develop EAU and Th1 responses to IRBP without pertussis treatment. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10549794&form=6&db=m Chronic activation of ORL1 receptor induces supersensitization of adenylyl cyclase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10551275&form=6&db=m Differential sensitivity of 5-HT1B auto and heteroreceptors. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10551718&form=6&db=m Vascular smooth muscle proliferation: synergistic interaction between serotonin and low density lipoproteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10553654&form=6&db=m Rational medium design for Bordetella pertussis: basic metabolism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10556777&form=6&db=m Effect of GHRH and peptides from the vasoactive intestinal peptide family on cAMP production of human cancer cell lines in vitro. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10557318&form=6&db=m Specific binding of proinsulin C-peptide to human cell membranes. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10559144&form=6&db=m G protein beta3 subunit 825T allele and enhanced coronary vasoconstriction on alpha(2)-adrenoceptor activation. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10559239&form=6&db=m Activation of rat frizzled-1 promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via pathways that require Galpha(q) and Galpha(o) function. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10562503&form=6&db=m Enhanced HIV-1 replication by chemokines constitutively expressed in secondary lymphoid tissues. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10564102&form=6&db=m Somatostatin peptides inhibit basolateral potassium channels in human colonic crypts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10564143&form=6&db=m cAMP production by piglet cerebral vascular smooth muscle cells: pH(o), pH(i), and permissive action of PGI(2). therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10564365&form=6&db=m Voltage-independent autocrine modulation of L-type channels mediated by ATP, opioids and catecholamines in rat chromaffin cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10565839&form=6&db=m Neuropeptide-Y stimulation of extracellular signal-regulated kinases in human erythroleukemia cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10567858&form=6&db=m Muscarinic regulation of basal versus thyrotropin-releasing hormone-induced prolactin secretion in rat anterior pituitary cells. differential roles of nitric oxide and intracellular calcium mobilization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10569699&form=6&db=m Tyrosine phosphorylation of a low molecular weight protein induced by RANTES in T-lymphocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10570282&form=6&db=m The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10570313&form=6&db=m H-Ras signals to cytoskeletal machinery in induction of integrin-mediated adhesion of T cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10570948&form=6&db=m Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10571530&form=6&db=m Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10571539&form=6&db=m Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10572077&form=6&db=m Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10574573&form=6&db=m Evidence that conditionally immortalized human osteoblasts express an osteocalcin receptor. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10575086&form=6&db=m GABA(B) receptor activation inhibits N- and P/Q-type calcium channels in cultured lamprey sensory neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10575131&form=6&db=m Evidence for an intracellular niche for Bordetella pertussis in broncho-alveolar lavage cells of mice. causal interaction,diagnostic usage,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10576564&form=6&db=m Trp-Lys-Tyr-Met-Val-Met activates mitogen-activated protein kinase via a PI-3 kinase-mediated pathway independent of PKC. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10577992&form=6&db=m Opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte apoptosis : role of a pertussis toxin-sensitive G protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10578131&form=6&db=m Roles of atypical protein kinase C in lysophosphatidic acid-induced type II adenylyl cyclase activation in RAW 264.7 macrophages. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10579343&form=6&db=m Parathyroid hormone activates mitogen-activated protein kinase in opossum kidney cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10580092&form=6&db=m Functional analysis of a human A(1) adenosine receptor/green fluorescent protein/G(i1)alpha fusion protein following stable expression in CHO cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10580202&form=6&db=m Vaccination of infants with a four-dose and a three-dose vaccination schedule. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10580209&form=6&db=m Immunogenicity study of a combined diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis vaccine used to reconstitute a freeze-dried Haemophilus influenzae type b vaccine (DTaP-IPV//PRP-T) administered simultaneously with a hepatitis B vaccine at two, three and four months of life. diagnostic usage,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10580406&form=6&db=m T cell-derived suppressive activity: evidence of autocrine noncytolytic control of HIV type 1 transcription and replication. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10583381&form=6&db=m Activation of human neutrophils by a synthetic anti-microbial peptide, KLKLLLLLKLK-NH2, via cell surface calreticulin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10583908&form=6&db=m Characterization of the signal transduction pathways mediating noradrenaline-stimulated MAPK activation and c-fos expression in oligodendrocyte progenitors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10583963&form=6&db=m Use of chemokine receptors by poxviruses. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10584906&form=6&db=m Semiquantitative polymerase chain reaction enzyme immunoassay for the diagnosis of pertussis. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10585401&form=6&db=m Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10585418&form=6&db=m Constitutive G(i2)-dependent activation of adenylyl cyclase type II by the 5-HT1A receptor. Inhibition by anxiolytic partial agonists. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10586940&form=6&db=m Macrophages and dendritic cells in IRBP-induced experimental autoimmune uveoretinitis in B10RIII mice. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10587085&form=6&db=m Pertussis toxin decreases absence seizures and GABA(B) receptor binding in thalamus of a genetically prone rat (GAERS). ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10588484&form=6&db=m Nonselective cationic currents activated by acetylcholine in swine tracheal smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10588714&form=6&db=m Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10590173&form=6&db=m Lysophosphatidic acid-induced Ca(2+) mobilization in the neural retina of chick embryo. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10591061&form=6&db=m Role of the D2 dopamine receptor in molecular adaptation to chronic hypoxia in PC12 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10591161&form=6&db=m Induction of a specific antibody response to Bordetella pertussis antigens in cultures of human peripheral blood mononuclear cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10591477&form=6&db=m Two different P2Y receptors linked to steroidogenesis in bovine adrenocortical cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10592076&form=6&db=m Local reactions and IgE antibodies to pertussis toxin after acellular diphtheria-tetanus-pertussis immunization. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10592813&form=6&db=m Production and purification of Bordetella pertussis toxin. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10592823&form=6&db=m Preparation and characterization of Pertussis toxin subunits. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10594325&form=6&db=m Agonist-induced GTPgamma35S binding mediated by human 5-HT(2C) receptors expressed in human embryonic kidney 293 cells. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10595650&form=6&db=m Lysophosphatidic acid activates nuclear factor kappa B and induces proinflammatory gene expression in endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10598016&form=6&db=m High concentrations of histamine stimulate equine polymorphonuclear neutrophils to produce reactive oxygen species. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10598576&form=6&db=m Pertussis toxin-sensitive and -insensitive thrombin stimulation of Shc phosphorylation and mitogenesis are mediated through distinct pathways. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10598579&form=6&db=m Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10598791&form=6&db=m Characterisation of human recombinant somatostatin receptors. 4. Modulation of phospholipase C activity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600161&form=6&db=m Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600185&form=6&db=m Development of acellular pertussis vaccines. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600188&form=6&db=m Overview of recent clinical trials of acellular pertussis vaccines. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600191&form=6&db=m DTaP vaccines from north american vaccine (NAVA): composition and critical parameters. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600193&form=6&db=m The vaccine containing recombinant pertussis toxin induces early and long-lasting protection. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600202&form=6&db=m Approaches to the control of acellular pertussis vaccines. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600203&form=6&db=m Acellular pertussis vaccines: neutralization by immune sera of the lethality of pertussis toxin and viable Bordetella pertussis for chick embryos. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600205&form=6&db=m Physico-chemical analysis of Bordetella pertussis antigens. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600208&form=6&db=m Evaluation of a guinea pig model to assess interference in the immunogenicity of different components of a combination vaccine comprising diphtheria, tetanus and acellular pertussis (DTaP) vaccine and haemophilus influenzae type b capsular polysaccharide conjugate vaccine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600774&form=6&db=m Asymmetric distribution of muscarinic acetylcholine receptors in Madin-Darby canine kidney cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600786&form=6&db=m Effects of parathyroid hormone-related protein on human mesangial cells in culture. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10601267&form=6&db=m Chemoattractant receptors activate distinct pathways for chemotaxis and secretion. Role of G-protein usage. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10601431&form=6&db=m Adenosine A1 and class II metabotropic glutamate receptors mediate shared presynaptic inhibition of retinotectal transmission. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10601975&form=6&db=m A novel mechanism for the melatonin inhibition of testosterone secretion by rat Leydig cells: reduction of GnRH-induced increase in cytosolic Ca2+. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10602318&form=6&db=m Desensitization and resensitization of beta 1- and putative beta 4-adrenoceptor mediated responses occur in parallel in a rat model of cardiac failure. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10603441&form=6&db=m Inhibition of Ca(2+) entry caused by depolarization in acetylcholine-stimulated antral mucous cells of guinea pig: G protein regulation of Ca(2+) permeable channels. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10604944&form=6&db=m Assessment of mechanisms involved in antinociception caused by sesquiterpene polygodial. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10604950&form=6&db=m Coupling of human delta-opioid receptor to retinal rod transducin in Chinese hamster ovary cells. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10607883&form=6&db=m Functional assessment of recombinant human alpha(2)-adrenoceptor subtypes with cytosensor microphysiometry. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10608281&form=6&db=m Myr+-Gi2 alpha and Go alpha subunits restore the efficacy of opioids, clonidine and neurotensin giving rise to antinociception in G-protein knock-down mice. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10608284&form=6&db=m The role of potassium channels in antihistamine analgesia. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10608285&form=6&db=m Pertussis toxin treatment differentially affects cholinergic and dopaminergic receptor stimulation of midbrain dopaminergic neurons. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10610182&form=6&db=m A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10611469&form=6&db=m Correlation between low/high affinity ratios for 5-HT(1A) receptors and intrinsic activity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10611718&form=6&db=m Anterior uveitis in murine relapsing experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10614772&form=6&db=m Trp-Lys-Tyr-Met-Val-D-Met is a chemoattractant for human phagocytic cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10617148&form=6&db=m Entrapping of impermeant probes of different size into nonpermeabilized synaptosomes as a method to study presynaptic mechanisms. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10617617&form=6&db=m Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10617657&form=6&db=m Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10617677&form=6&db=m Microtubule-dependent regulation of alpha(2B) adrenergic receptors in polarized MDCKII cells requires the third intracellular loop but not G protein coupling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10617687&form=6&db=m Use of constitutive G protein-coupled receptor activity for drug discovery. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10617748&form=6&db=m Safety and immunogenicity of six acellular pertussis vaccines and one whole-cell pertussis vaccine given as a fifth dose in four- to six-year-old children. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10617749&form=6&db=m Extensive swelling after booster doses of acellular pertussis-tetanus-diphtheria vaccines. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10618063&form=6&db=m Polymorphism in the pertussis toxin promoter region affecting the DNA-based diagnosis of Bordetella infection. causal interaction,diagnostic usage,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10619182&form=6&db=m Characterization of the endothelin-1-induced regulation of L-type Ca2+ current in rabbit ventricular myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10620669&form=6&db=m Vectors to achieve selective expression of vaccine antigens within eukaryotic cells using Salmonella spp. as carrier strains. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10622284&form=6&db=m Participation of cAMP in the facilitatory action of beta,gamma-methylene ATP on the noradrenaline release from rabbit ear artery. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10623856&form=6&db=m Molecular analysis of CCR-3 events in eosinophilic cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10624095&form=6&db=m [Induction of protective immunity for Bordetella pertussis by nasal inoculation of pertussis vaccine in mice] ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10625048&form=6&db=m The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10626903&form=6&db=m Pertussis toxin treatment in vivo reduces surface expression of the adhesion integrin leukocyte function antigen-1 (LFA-1). ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10629036&form=6&db=m Normal hematopoiesis and inflammatory responses despite discrete signaling defects in Galpha15 knockout mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10629205&form=6&db=m Overexpression of the RNA polymerase alpha subunit reduces transcription of Bvg-activated virulence genes in Bordetella pertussis. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10629439&form=6&db=m Protein kinase C-dependent coupling of alpha(2A/D)-adrenergic receptors to phospholipase D. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10629468&form=6&db=m Effect of acellular pertussis vaccine on the development of allergic sensitization to environmental allergens in adults. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10629763&form=6&db=m Regulation of GTPase and adenylate cyclase activity by amyloid beta-peptide and its fragments in rat brain tissue. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10629884&form=6&db=m [Goniodomin A induces modulation of actomyosin ATPase activity mediated through conformational change of actin] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10632016&form=6&db=m Gi/Go couple met-enkephalin to inhibition of cholinergic and beta-adrenergic stimulation of lacrimal secretion. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10632590&form=6&db=m P2Y purinoceptors inhibit exocytosis in adrenal chromaffin cells via modulation of voltage-operated calcium channels. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10634810&form=6&db=m Stimulation of phospholipase D activity by oxidized LDL in mouse peritoneal macrophages. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10634853&form=6&db=m Role of pertussis toxin-sensitive G-proteins in synaptic transmission and plasticity at corticostriatal synapses. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10634871&form=6&db=m Evidence for paracrine signaling between macrophages and bovine adrenal chromaffin cell Ca(2+) channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10635060&form=6&db=m The bradykinin B2 receptor couples less efficiently than the angiotensin AT1 receptor to the G protein Gq in transiently transfected COS-7 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10637714&form=6&db=m Mutation analysis of pertussis toxin promoter. causal interaction,diagnostic usage,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10639178&form=6&db=m Effect of G protein heterotrimer composition on coupling of neurotransmitter receptors to N-type Ca(2+) channel modulation in sympathetic neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10639408&form=6&db=m Genital antibody responses in mice after intranasal infection with an attenuated candidate vector strain of Bordetella pertussis. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10640301&form=6&db=m Functional and molecular properties of the human recombinant Y4 receptor: resistance to agonist-promoted desensitization. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10640315&form=6&db=m Diuretic response to adenosine A(1) receptor blockade in normotensive and spontaneously hypertensive rats: role of pertussis toxin-sensitive G-proteins. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10640689&form=6&db=m Sphingosine 1-phosphate induces expression of early growth response-1 and fibroblast growth factor-2 through mechanism involving extracellular signal-regulated kinase in astroglial cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10641864&form=6&db=m Regulation of porcine adipocyte metabolism by insulin and adenosine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10642513&form=6&db=m Gi-mediated translocation of GLUT4 is independent of p85/p110alpha and p110gamma phosphoinositide 3-kinases but might involve the activation of Akt kinase. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10642826&form=6&db=m Muscarinic regulation of Ca2+ oscillation frequency in GH3 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10643593&form=6&db=m [Regulation of inositol-1,4,5-triphosphate receptor by G(i)-protein] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10643816&form=6&db=m Prosaptide D5 reverses hyperalgesia: inhibition of calcium channels through a pertussis toxin-sensitive G-protein mechanism in the rat. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10644052&form=6&db=m Biological actions of the free acid of hepoxilin A3 on human neutrophils. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10644509&form=6&db=m Lysophosphatidic acid rapidly induces protein kinase D activation through a pertussis toxin-sensitive pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10644671&form=6&db=m Association of heterotrimeric G(i) with the insulin-like growth factor-I receptor. Release of G(betagamma) subunits upon receptor activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10645896&form=6&db=m Curosurf modulates cAMP accumulation in human monocytes through a membrane-controlled mechanism. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10646518&form=6&db=m Membrane-bound form of ADP-ribosyl cyclase in rat cortical astrocytes in culture. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10647703&form=6&db=m The mechanism of contraction by 2-chloroadenosine in cat detrusor muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10647867&form=6&db=m Regulation of intracellular calcium by extracellular nucleotides in pig tracheal submucosal gland cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10648006&form=6&db=m Platelet-activating factor activates mitogen-activated protein kinases through the activation of phosphatidylinositol 3-kinase and tyrosine kinase in human eosinophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10648411&form=6&db=m Adenosine triphosphate-induced oxygen radical production and CD11b up-regulation: Ca(++) mobilization and actin reorganization in human eosinophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10648637&form=6&db=m Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10648697&form=6&db=m Somatostatin modulates voltage-gated K(+) and Ca(2+) currents in rod and cone photoreceptors of the salamander retina. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10650990&form=6&db=m Ammonium triggers calcium elevation in cultured mouse microglial cells by initiating Ca(2+) release from thapsigargin-sensitive intracellular stores. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10651140&form=6&db=m Sphingolipid receptor signaling and function in human bladder carcinoma cells: inhibition of LPA- but enhancement of thrombin-stimulated cell motility. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10651866&form=6&db=m Differential signalling of the chemokine receptor CXCR4 by stromal cell-derived factor 1 and the HIV glycoprotein in rat neurons and astrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10652210&form=6&db=m Sphingosine 1-phosphate stimulates tyrosine phosphorylation of focal adhesion kinase and chemotactic motility of endothelial cells via the G(i) protein-linked phospholipase C pathway. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10652364&form=6&db=m Prolactin-releasing peptide activation of the prolactin promoter is differentially mediated by extracellular signal-regulated protein kinase and c-Jun N-terminal protein kinase. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10655388&form=6&db=m Specificity and sensitivity of high levels of immunoglobulin G antibodies against pertussis toxin in a single serum sample for diagnosis of infection with Bordetella pertussis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10657543&form=6&db=m Angiotensin II type 1 receptor-mediated increase in cytosolic Ca(2+) and proliferation in mesothelial cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10657608&form=6&db=m Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10658194&form=6&db=m Multiple polyphosphoinositide pathways regulate apoptotic signalling in a dorsal root ganglion derived cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10659986&form=6&db=m Pertussis vaccine and pertussis toxin increase lithium levels in rats: possible role of G-proteins. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10659993&form=6&db=m Pharmacological and functional characterization of bradykinin receptors in rat cultured vascular smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10660578&form=6&db=m Coupling of the muscarinic m2 receptor to G protein-activated K(+) channels via Galpha(z) and a receptor-Galpha(z) fusion protein. Fusion between the receptor and Galpha(z) eliminates catalytic (collision) coupling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10666407&form=6&db=m The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10669040&form=6&db=m Sensitization of the adenylyl cyclase system in cloned kappa-opioid receptor-transfected cells following sustained agonist treatment: A chimeric study using G protein alpha(i)2/alpha(q) subunits. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10669727&form=6&db=m Distinct roles for Galpha(i)2 and Gbetagamma in signaling to DNA synthesis and Galpha(i)3 in cellular transformation by dopamine D2S receptor activation in BALB/c 3T3 cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10670413&form=6&db=m The prostaglandin E series modulates high-voltage-activated calcium channels probably through the EP3 receptor in rat paratracheal ganglia. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10670414&form=6&db=m Dopamine activates inward rectifier K+ channel in acutely dissociated rat substantia nigra neurones. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10670566&form=6&db=m A nasal whole-cell pertussis vaccine induces specific systemic and cross-reactive mucosal antibody responses in human volunteers. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10671485&form=6&db=m Trypsin stimulates integrin alpha(5)beta(1)-dependent adhesion to fibronectin and proliferation of human gastric carcinoma cells through activation of proteinase-activated receptor-2. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10671499&form=6&db=m Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10674988&form=6&db=m Functional and molecular characterization of VIP receptor--effector system in rat developing immunocompetent cells: G protein involvement. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10677366&form=6&db=m Involvement of Gialpha2 in sodium butyrate-induced erythroblastic differentiation of K562 cells. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10678138&form=6&db=m Leucine-2-alanine enkephalin induced delta opioid receptors internalization expressed stably in CHO cells. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10678742&form=6&db=m Lithium activates mammalian Na+/H+ exchangers: isoform specificity and inhibition by genistein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10678938&form=6&db=m Mutations in the S1 subunit of pertussis toxin that affect secretion. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10679229&form=6&db=m Enhancement of the migration of metastatic human breast cancer cells by phosphatidic acid. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10679247&form=6&db=m Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10680989&form=6&db=m Immunogenicity and safety of a tetravalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10681540&form=6&db=m Protein kinase C activation stimulates the phosphorylation and internalization of the sst2A somatostatin receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10683250&form=6&db=m Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10683510&form=6&db=m Analysis of experimental autoimmune encephalomyelitis induced in F344 rats by pertussis toxin administration. causal interaction,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10683524&form=6&db=m A DPDPE-induced enhancement of inward rectifier potassium current via opioid receptor in neuroblastomaxglioma NG108-15 cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10685868&form=6&db=m Pertussis toxin suppresses carbachol-evoked cardiodepression but does not modify cardiostimulation mediated through beta1- and putative beta4-adrenoceptors in mouse left atria: no evidence for beta2- and beta3-adrenoreceptor function. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10686091&form=6&db=m Effects of pertussis toxin and galpha-protein-specific antibodies on phosphoinositide hydrolysis in rat brain membranes after cholinergic denervation and hippocampal sympathetic ingrowth. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10688429&form=6&db=m Eosinophil activation by eotaxin--eotaxin primes the production of reactive oxygen species from eosinophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10688632&form=6&db=m Ligand-induced changes in surface mu-opioid receptor number: relationship to G protein activation? causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10688807&form=6&db=m GCP-2-induced internalization of IL-8 receptors: hierarchical relationships between GCP-2 and other ELR(+)-CXC chemokines and mechanisms regulating CXCR2 internalization and recycling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10696085&form=6&db=m Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10699133&form=6&db=m Clinical validation of a polymerase chain reaction assay for the diagnosis of pertussis by comparison with serology, culture, and symptoms during a large pertussis vaccine efficacy trial. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10699641&form=6&db=m Enhanced negative chronotropy by inhibitory receptors in transgenic heart overexpressing beta(2)-adrenoceptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10699970&form=6&db=m Adaptive responses of human monocytes infected by bordetella pertussis: the role of adenylate cyclase hemolysin. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10704341&form=6&db=m Caspase-dependent apoptosis of cells expressing the chemokine receptor CXCR4 is induced by cell membrane-associated human immunodeficiency virus type 1 envelope glycoprotein (gp120). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10704822&form=6&db=m The GTP-binding protein G(ialpha) translocates to kinetochores and regulates the M-G(1) cell cycle transition of Swiss 3T3 cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10706729&form=6&db=m The coupling of 5-oxo-eicosanoid receptors to heterotrimeric G proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10706738&form=6&db=m Genetic analysis of the influence of pertussis toxin on experimental allergic encephalomyelitis susceptibility: an environmental agent can override genetic checkpoints. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10706774&form=6&db=m Role of lysophosphatidic acid and rho in glioma cell motility. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10708723&form=6&db=m The mechanisms of alpha(2)-adrenoceptor agonist-induced contraction in longitudinal muscle of the porcine uterus. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10711345&form=6&db=m Somatostatin-induced control of cytosolic free calcium in pituitary tumour cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10711357&form=6&db=m Ontogenic aspects of D1 receptor coupling to G proteins and regulation of rat jejunal Na+, K+ ATPase activity and electrolyte transport. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10712250&form=6&db=m Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10712420&form=6&db=m Ras/Rac-Dependent activation of p38 mitogen-activated protein kinases in smooth muscle cells stimulated by cyclic strain stress causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10712470&form=6&db=m Voltage-dependent, pertussis toxin insensitive inhibition of calcium currents by histamine in bovine adrenal chromaffin cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10712568&form=6&db=m Angiotensin II type 1 receptors stimulate protein synthesis in human cardiac fibroblasts via a Ca2+-sensitive PKC-dependent tyrosine kinase pathway. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10713263&form=6&db=m Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hippocampal [(3)H]GABA release. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10715521&form=6&db=m A randomised controlled trial with a diphtheria-tetanus-acellular pertussis (dTpa) vaccine in adults. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10715525&form=6&db=m Effect of pertussis toxin on the induction of nitric oxide synthesis in murine macrophages and on protection in vivo. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10716375&form=6&db=m Pertussis toxin enhances human immunodeficiency virus type 1 replication. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10717335&form=6&db=m Seroepidemiology of Bordetella pertussis infections in the Spanish population: a cross-sectional study. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10719293&form=6&db=m Demonstration of mast cell chemotactic activity in bronchoalveolar lavage fluid collected from asthmatic patients before and during pollen season. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10720524&form=6&db=m Correlation between pertussis toxin IgG antibodies in postvaccination sera and subsequent protection against pertussis. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10721009&form=6&db=m Evidence of endogenous mono-ADP-ribosylation of cardiac proteins via anti-ADP-ribosylarginine immunoreactivity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10722585&form=6&db=m Role of adhesins and toxins in invasion of human tracheal epithelial cells by Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10727515&form=6&db=m Preactivation permits subsequent stimulation of phospholipase C by G(i)-coupled receptors. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10727521&form=6&db=m Differential superactivation of adenylyl cyclase isozymes after chronic activation of the CB(1) cannabinoid receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10727529&form=6&db=m A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleoside triphosphates. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10727531&form=6&db=m Alterations in detergent solubility of heterotrimeric G proteins after chronic activation of G(i/o)-coupled receptors: changes in detergent solubility are in correlation with onset of adenylyl cyclase superactivation. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10733341&form=6&db=m G protein G alpha q/11 and G alpha i1,2 are activated by pancreastatin receptors in rat liver: studies with GTP-gamma 35S and azido-GTP-alpha-32P. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10734167&form=6&db=m ATP inhibits glutamate synaptic release by acting at P2Y receptors in pyramidal neurons of hippocampal slices. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10737627&form=6&db=m Regulation of adenylyl cyclase, ERK1/2, and CREB by Gz following acute and chronic activation of the delta-opioid receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10737891&form=6&db=m Extracellular ATP-mediated phospholipase A(2) activation in rat thyroid FRTL-5 cells: regulation by a G(i)/G(o) protein, Ca(2+), and mitogen-activated protein kinase. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10738087&form=6&db=m Induction of antigen-specific T cell responses in human volunteers after intranasal immunization with a whole-cell pertussis vaccine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10742288&form=6&db=m Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using extracellular acidification rate changes. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10742294&form=6&db=m Histamine H(3) receptors mediate inhibition of noradrenaline release from intestinal sympathetic nerves. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10742305&form=6&db=m P2Y(2) receptor-mediated proliferation of C(6) glioma cells via activation of Ras/Raf/MEK/MAPK pathway. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10746492&form=6&db=m Bordetella pertussis infection: pathogenesis, diagnosis, management, and the role of protective immunity. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10747002&form=6&db=m Biphasic actions of prostaglandin E(2) on the renal afferent arteriole : role of EP(3) and EP(4) receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10748000&form=6&db=m Rapid Ca2+ influx and diacylglycerol synthesis in growth hormone-mediated islet beta -cell mitogenesis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10748268&form=6&db=m Histamine H(3) receptor-mediated inhibition of endogenous acetylcholine release from the isolated, vascularly perfused rat stomach. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10749665&form=6&db=m The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10749796&form=6&db=m Regulation of NHE3 activity by G protein subunits in renal brush-border membranes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10754297&form=6&db=m Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10754298&form=6&db=m Fractalkine-mediated endothelial cell injury by NK cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10754331&form=6&db=m CX3C-chemokine, fractalkine-enhanced adhesion of THP-1 cells to endothelial cells through integrin-dependent and -independent mechanisms. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10757244&form=6&db=m Presynaptic inhibition and the participation of GABA(B) receptors at neuromuscular junctions of the crab Eriphia spinifrons. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10762323&form=6&db=m Inhibition of delayed rectifier K+ conductance in cultured rat cerebellar granule neurons by activation of calcium-permeable AMPA receptors. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10762352&form=6&db=m Acetylcholine stimulates cortical precursor cell proliferation in vitro via muscarinic receptor activation and MAP kinase phosphorylation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10762354&form=6&db=m Dynorphins directly inhibit neuronal nicotinic acetylcholine receptors in PC12 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10764666&form=6&db=m Sphingosine-1-phosphate and lysophosphatidic acid stimulate endothelial cell migration. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10766452&form=6&db=m Islet amyloid polypeptide regulates multiple steps in stimulus-secretion coupling of beta cells in rat pancreatic islets. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10766916&form=6&db=m Pregnancy switches adrenergic signal transduction in rat and human uterine myocytes as probed by BKCa channel activity. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10770786&form=6&db=m Antibacterial agents and release of periplasmic pertussis toxin from Bordetella pertussis. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10770951&form=6&db=m Beta 3- and alpha1-adrenergic Erk1/2 activation is Src- but not Gi-mediated in Brown adipocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10770956&form=6&db=m p38 mitogen-activated protein kinase pathway protects adult rat ventricular myocytes against beta -adrenergic receptor-stimulated apoptosis. Evidence for Gi-dependent activation. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10771034&form=6&db=m Mechanism of histamine release induced by levofloxacin, a fluoroquinolone antibacterial agent. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10772340&form=6&db=m Tyrosine phosphorylation of a 34-kDa protein induced by cross-linking a novel glycosylphosphatidylinositol-anchored glycoprotein (GPI-80) on human neutrophils that may regulate their adherence and migration. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10773981&form=6&db=m [Immunological effect of systemically administered allopurinol in experimental autoimmune uveitis] ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10777542&form=6&db=m Novel inhibition of gbetagamma-activated potassium currents induced by M(2) muscarinic receptors via a pertussis toxin-insensitive pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10777773&form=6&db=m Evidence that G(z)-proteins couple to hypothalamic 5-HT(1A) receptors in vivo. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10779277&form=6&db=m Comparison of mechanisms of IL-3 induced histamine release and IL-3 priming effect on human basophils. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10779388&form=6&db=m Lysophosphatidic acid modulates alpha(1b)-adrenoceptor phosphorylation and function: roles of Gi and phosphoinositide 3-kinase. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10779394&form=6&db=m Selective enhancement of beta-adrenergic receptor signaling by overexpression of adenylyl cyclase type 6: colocalization of receptor and adenylyl cyclase in caveolae of cardiac myocytes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10779550&form=6&db=m The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10780989&form=6&db=m Mepyramine but not cimetidine or clobenpropit blocks pertussis toxin-induced histamine sensitization in rats. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10781010&form=6&db=m Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10781287&form=6&db=m Isoflurane preconditions myocardium against infarction via activation of inhibitory guanine nucleotide binding proteins. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10781927&form=6&db=m Activation of mitogen-activated protein kinase by oxidized low-density lipoprotein in canine cultured vascular smooth muscle cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10781928&form=6&db=m Increase of [Ca(2+)]i and release of arachidonic acid via activation of M2 receptor coupled to Gi and rho proteins in oesophageal muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10781929&form=6&db=m Effect of pertussis toxin on insulin-induced signal transduction in rat adipocytes and soleus muscles. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10781931&form=6&db=m Mastoparan transiently permeabilizes Swiss 3T3 cells and induces c-fos proto-oncogene expression. Role of calcium and G protein activation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10783014&form=6&db=m Adult formulation of a five component acellular pertussis vaccine combined with diphtheria and tetanus toxoids and inactivated poliovirus vaccine is safe and immunogenic in adolescents and adults. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10786826&form=6&db=m Possible participation of an islet B-cell calcium-sensing receptor in insulin release. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10787407&form=6&db=m Regulation of F-actin and endoplasmic reticulum organization by the trimeric G-protein Gi2 in rat hepatocytes. Implication for the activation of store-operated Ca2+ inflow. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10787424&form=6&db=m Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10787441&form=6&db=m Regulation of acetylated low density lipoprotein uptake in macrophages by pertussis toxin-sensitive G proteins. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10788429&form=6&db=m P2Y receptor-mediated inhibition of tumor necrosis factor alpha -stimulated stress-activated protein kinase activity in EAhy926 endothelial cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10788802&form=6&db=m Rho-mediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphingosine 1-phosphate, a bioactive lysophospholipid released from activated platelets. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10790422&form=6&db=m The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10790434&form=6&db=m Primary role for Gi protein signaling in the regulation of interleukin 12 production and the induction of T helper cell type 1 responses. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10794500&form=6&db=m Blockage of amyloid beta peptide-induced cytosolic free calcium by fullerenol-1, carboxylate C60 in PC12 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10794516&form=6&db=m Positive and negative inotropic effects of muscarinic receptor stimulation in mouse left atria. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10794715&form=6&db=m Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10799507&form=6&db=m Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10799649&form=6&db=m alpha(2A)-adrenoceptor: G(alphai1) protein-mediated pertussis toxin-resistant attenuation of G(s) coupling to the cyclic AMP pathway. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10799858&form=6&db=m Effects of continuous exposure to stromal cell-derived factor-1 alpha on T cell rolling and tight adhesion to monolayers of activated endothelial cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10800936&form=6&db=m Glutamate-stimulated activation of DNA synthesis via mitogen-activated protein kinase in primary astrocytes: involvement of protein kinase C and related adhesion focal tyrosine kinase. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10800964&form=6&db=m Characterization of a receptor for insect tachykinin-like peptide agonists by functional expression in a stable Drosophila Schneider 2 cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10801289&form=6&db=m GABA(B) presynaptically modulates suprachiasmatic input to hypothalamic paraventricular magnocellular neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10802025&form=6&db=m Cerebellar CB(1) receptor mediation of Delta(9)-THC-induced motor incoordination and its potentiation by ethanol and modulation by the cerebellar adenosinergic A(1) receptor in the mouse. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10802710&form=6&db=m Active movement of T cells away from a chemokine. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10803255&form=6&db=m [Humoral reaction to Bordetella pertussis antigens: pertussis toxin, filamentous hemagglutinin and lipopolysaccharide in children with clinical symptoms of whooping cough. I. Antibody level for B pertussis antigens in children without respiratory tract infection symptoms] causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10803256&form=6&db=m [Humoral reaction to Bordetella pertussis antigens: pertussis toxin, filamentous hemagglutinin and lipopolysaccharide in children with clinical symptoms of whooping cough. II. Occurence and level of B. pertussis antigens in children with suspected whooping cough] diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10803576&form=6&db=m Cannabinoid CB1 receptor-mediated inhibition of prolactin release and signaling mechanisms in GH4C1 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10804947&form=6&db=m Seroprevalence of pertussis antibodies among adolescents in Israel. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10807934&form=6&db=m The regulator of G protein signaling RGS4 selectively enhances alpha 2A-adreoreceptor stimulation of the GTPase activity of Go1alpha and Gi2alpha. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10808045&form=6&db=m Experimental allergic neuritis in the SJL/J mouse: induction of severe and reproducible disease with bovine peripheral nerve myelin and pertussis toxin with or without interleukin-12. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10808081&form=6&db=m Local injection of pertussis toxin attenuates morphine withdrawal excitation of rat supraoptic nucleus neurones. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10811016&form=6&db=m Positive regulation of human T cell activation by Gi2 proteins and interleukin-8. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10813380&form=6&db=m Cardiac swelling-induced chloride current is enhanced by endothelin. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10816544&form=6&db=m Use of pertussis toxin encoded by ptx genes from Bordetella bronchiseptica to model the effects of antigenic drift of pertussis toxin on antibody neutralization. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10816567&form=6&db=m Stimulation of human neutrophils by chemotactic factors is associated with the activation of phosphatidylinositol 3-kinase gamma. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10817567&form=6&db=m Soluble vascular cell adhesion molecule 1 mediation of monocyte chemotaxis in rheumatoid arthritis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10818132&form=6&db=m Muscarinic inhibition of calcium current and M current in Galpha q-deficient mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10819790&form=6&db=m Somatostatin inhibits follicle-stimulating hormone-induced adenylyl cyclase activity and proliferation in immature porcine Sertoli cell via sst2 receptor. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10820724&form=6&db=m ADP-ribosylation of alpha-Gi proteins by pertussis toxin. Positional dissection of acceptor sites using membrane anchored synthetic peptides. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10820955&form=6&db=m Pertussis seroepidemiology in Taipei. diagnostic usage,ongoing research,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10821783&form=6&db=m Somatostatin potentiates NMDA receptor function via activation of InsP(3) receptors and PKC leading to removal of the Mg(2+) block without depolarization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10822058&form=6&db=m Activation of G protein by opioid receptors: role of receptor number and G-protein concentration. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10822176&form=6&db=m Functional compartments in rat mast cells for cAMP and calcium on histamine release. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10824737&form=6&db=m Insulin stimulates the release of a subset of GPI-anchored proteins in a G-protein independent manner. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10825231&form=6&db=m Effects of pertussis toxin on extracellular signal-regulated kinase activation in hepatocytes by hormones and receptor-independent agents: evidence suggesting a stimulatory role of G(i) proteins at a level distal to receptor coupling. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10825384&form=6&db=m Coupling of I(1) imidazoline receptors to the cAMP pathway: studies with a highly selective ligand, benazoline. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10825387&form=6&db=m Two different signaling mechanisms involved in the excitation of rat sympathetic neurons by uridine nucleotides. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10825470&form=6&db=m Actions of epoxyeicosatrienoic acid on large-conductance Ca(2+)-activated K(+) channels in pituitary GH(3) cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10825481&form=6&db=m Muscarinic receptors modulate intracellular calcium level in chick sensory neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10825586&form=6&db=m Specific T cell deletion by transfected human monocytes expressing fas ligand and antigen. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10827015&form=6&db=m Isoproterenol and cAMP regulation of the human brain natriuretic peptide gene involves Src and Rac. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10827134&form=6&db=m Coupling function of endogenous alpha(1)- and beta-adrenergic receptors in mouse cardiomyocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10830311&form=6&db=m Luteinizing hormone (LH) drives diverse intracellular calcium second messenger signals in isolated porcine ovarian thecal cells: preferential recruitment of intracellular Ca2+ oscillatory cells by higher concentrations of LH. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10832611&form=6&db=m Cloning, expression, functional coupling and pharmacological characterization of the rat dopamine D4 receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10835048&form=6&db=m G protein-mediated FMRFamidergic modulation of calcium influx in dissociated heart muscle cells from squid, Loligo forbesii. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10835429&form=6&db=m Smoothened activates Galphai-mediated signaling in frog melanophores. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10837180&form=6&db=m Cell-mediated immunity and antibody responses to Bordetella pertussis antigens in children with a history of pertussis infection and in recipients of an acellular pertussis vaccine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10837821&form=6&db=m Differential modulatory roles of cholera toxin and pertussis toxin in the regulation of pain responses induced by excitatory amino acids administered intrathecally in mice. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10838155&form=6&db=m Store-operated Ca(2+) inflow in Reuber hepatoma cells is inhibited by voltage-operated Ca(2+) channel antagonists and, in contrast to freshly isolated hepatocytes, does not require a pertussis toxin-sensitive trimeric GTP-binding protein. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10840035&form=6&db=m beta 2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-Raf. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10840646&form=6&db=m The effects of hydrostatic pressure on pertussis toxin-catalyzed ribosylation of G proteins from deep-living macrourid fishes. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10842167&form=6&db=m Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10843712&form=6&db=m Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10843876&form=6&db=m G(i)-dependent suppression of beta(1)-adrenoceptor effects in ventricular myocytes from NE-treated guinea pigs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10843992&form=6&db=m N-Formyl peptide receptor ligation induces rac-dependent actin reorganization through Gbeta gamma subunits and class Ia phosphoinositide 3-kinases. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10844018&form=6&db=m Endogenous regulator of G-protein signaling proteins modify N-type calcium channel modulation in rat sympathetic neurons. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10844601&form=6&db=m Thrombin is a novel regulator of hexokinase activity in mesangial cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10846186&form=6&db=m Epidermal growth factor receptor transactivation mediates substance P-induced mitogenic responses in U-373 MG cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10847582&form=6&db=m Functional trans-inactivation of insulin receptor kinase by growth-inhibitory angiotensin II AT2 receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10850736&form=6&db=m Cellular mechanism of action of cognitive enhancers: effects of nefiracetam on neuronal Ca2+ channels. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10851245&form=6&db=m Latrotoxin stimulates secretion in permeabilized cells by regulating an intracellular Ca2+ - and ATP-dependent event: a role for protein kinase C. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10851980&form=6&db=m [The development of a process for culturing Bordetella pertussis immobilized on a polyurethane carrier] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10854264&form=6&db=m Rod-type transducin alpha-subunit mediates a phototransduction pathway in the chicken pineal gland. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10854271&form=6&db=m Phospholipase C, protein kinase C, Ca(2+)/calmodulin-dependent protein kinase II, and tyrosine phosphorylation are involved in carbachol-induced phospholipase D activation in Chinese hamster ovary cells expressing muscarinic acetylcholine receptor of Caenorhabditis elegans. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10855034&form=6&db=m Characterization of ep prostanoid receptor subtypes in primary cultures of bovine ciliary epithelial cells by immunofluorescent microscopy and functional studies. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10857855&form=6&db=m Regulation of chemokine-induced transendothelial migration of T lymphocytes by endothelial activation: differential effects on naive and memory T cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10858221&form=6&db=m Importance of holotoxin assembly in Ptl-mediated secretion of pertussis toxin from Bordetella pertussis. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10859228&form=6&db=m G(i-1)/G(i-2)-dependent signaling by single-transmembrane natriuretic peptide clearance receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10860764&form=6&db=m Characterization of G-protein signaling in ventricular myocytes from the adult mouse heart: differences from the rat. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10860808&form=6&db=m Human fetal skin fibroblast migration stimulated by the autocrine growth factor bFGF is mediated by phospholipase A(2) via arachidonic acid without the involvement of pertussis toxin-sensitive G-protein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10860852&form=6&db=m VIP activates G(s) and G(i3) in rat alveolar macrophages and G(s) in HEK293 cells transfected with the human VPAC(1) receptor. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10861802&form=6&db=m Pertussis toxin treatment prevents 5-HT(5a) receptor-mediated inhibition of cyclic AMP accumulation in rat C6 glioma cells. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10862821&form=6&db=m Ethanol alters angiotensin II stimulated mitogen activated protein kinase in hepatocytes: agonist selectivity and ethanol metabolic independence. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10864463&form=6&db=m Slug is an essential target of TGFbeta2 signaling in the developing chicken heart. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10864477&form=6&db=m Lysophosphatidic acid stimulates intestinal restitution via cytoskeletal activation and remodeling. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10864894&form=6&db=m Activation of protein kinase B by the A(1)-adenosine receptor in DDT(1)MF-2 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10864897&form=6&db=m Tumour necrosis factor-alpha- and interleukin-1beta-stimulated cell proliferation through activation of mitogen-activated protein kinase in canine tracheal smooth muscle cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10864935&form=6&db=m Bidirectional modulation of exocytosis by angiotensin II involves multiple G-protein-regulated transduction pathways in chromaffin cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10866127&form=6&db=m Differential roles of Fas ligand in spontaneous and actively induced autoimmune encephalomyelitis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10867326&form=6&db=m Caprine sperm acrosome reaction: promotion by progesterone and homologous zona pellucida. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10867539&form=6&db=m G proteins regulate calcium channels in the luminal membranes of the rabbit nephron. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10867750&form=6&db=m Is autism a G-alpha protein defect reversible with natural vitamin A? causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10869343&form=6&db=m Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10869377&form=6&db=m Ca(2+) signaling via sigma(1)-receptors: novel regulatory mechanism affecting intracellular Ca(2+) concentration. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10869697&form=6&db=m Inhibition of potassium and calcium currents in neurones by molecularly-defined P2Y receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10871055&form=6&db=m Affinity purification of pancreastatin receptor-Gq/11 protein complex from rat liver membranes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10871313&form=6&db=m CB1 cannabinoid receptor-mediated cell migration. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10875753&form=6&db=m Muscarinic receptors controlling the carbachol-activated nonselective cationic current in guinea pig gastric smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10876840&form=6&db=m [The effect of methylated cyclodextrin on pertussis toxin accumulation in a Bordetella pertussis culture in a bioreactor] ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10878267&form=6&db=m Pharmacological study of signal transduction during stimulation of prothoracic glands from Manduca sexta. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10880077&form=6&db=m G-protein activity requirement for polymethylmethacrylate and titanium particle-induced fibroblast interleukin-6 and monocyte chemoattractant protein-1 release in vitro. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10881932&form=6&db=m Autocrine growth effect of IL-8 and GROalpha on a human pancreatic cancer cell line, Capan-1. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10882236&form=6&db=m The gene encoding the 17-kDa antigen of Bartonella henselae is located within a cluster of genes homologous to the virB virulence operon. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10882382&form=6&db=m Effects of sodium on agonist efficacy for G-protein activation in mu-opioid receptor-transfected CHO cells and rat thalamus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10884309&form=6&db=m Light transduction in invertebrate hyperpolarizing photoreceptors: possible involvement of a Go-regulated guanylate cyclase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10884372&form=6&db=m Lysophosphatidylcholine activates p38 and p42/44 mitogen-activated protein kinases in monocytic THP-1 cells, but only p38 activation is involved in its stimulated chemotaxis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10884555&form=6&db=m Pharmacologic reversal of pertussis toxin-induced thermal allodynia in mice. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10884797&form=6&db=m Marked increase in L-selectin-negative T cells in neonatal pertussis. The lymphocytosis explained? unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10886137&form=6&db=m Sphingosylphosphorylcholine stimulates contraction of fibroblast-embedded collagen gel. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10887101&form=6&db=m The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10887136&form=6&db=m Gi and Gq/11 proteins are involved in dissemination of myeloid leukemia cells to the liver and spleen, whereas bone marrow colonization involves Gq/11 but not Gi. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10888624&form=6&db=m Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10894791&form=6&db=m Extracellular ATP increases [CA(2+)](i) in distal tubule cells. I. Evidence for a P2Y2 purinoceptor. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10895075&form=6&db=m Thrombin stimulates pertussis toxin-sensitive and -insensitive GTPase activities and ADP-ribosylation of G(i) in human neuroblastoma SH-EP. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10895076&form=6&db=m Differences in efficacy and Na(+) sensitivity between alpha(2B) and alpha(2D) adrenergic receptors: implications for R and R* states. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10896171&form=6&db=m Human mu-opioid receptor overexpressed in Sf9 insect cells functionally coupled to endogenous Gi/o proteins. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10896718&form=6&db=m P2Y purinoceptor activation mobilizes intracellular Ca2+ and induces a membrane current in rat intracardiac neurones. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10896720&form=6&db=m Adenosine inhibits voltage-dependent Ca2+ currents in rat dissociated supraoptic neurones via A1 receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10896916&form=6&db=m Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10898747&form=6&db=m The contractile action of platelet-activating factor on gallbladder smooth muscle. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10898948&form=6&db=m Effect of light on phosphatidate phosphohydrolase activity of retina rod outer segments: the role of transducin. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10899191&form=6&db=m Depolarization-induced calcium channel facilitation in rod photoreceptors is independent of G proteins and phosphorylation. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10899284&form=6&db=m Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10899702&form=6&db=m Biological basis and possible physiological implications of melatonin receptor-mediated signaling in the rat epididymis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10899923&form=6&db=m Muscarinic activation of mitogen-activated protein kinase in PC12 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10900022&form=6&db=m gamma-aminobutyric acid type B receptors are expressed and functional in mammalian cardiomyocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10900230&form=6&db=m Agonist-directed trafficking of porcine alpha(2A)-adrenergic receptor signaling in Chinese hamster ovary cells: l-isoproterenol selectively activates G(s). diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10900259&form=6&db=m Inhibition of alpha(1)-adrenergic-mediated responses in rat ventricular myocytes by adenosine A(1) receptor activation: role of the K(ATP) channel. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10901171&form=6&db=m Differential effects of cholera toxin and pertussis toxin on the c-fos and c-jun mRNA expression in rat C6 glioma cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10903920&form=6&db=m Immediate and neurotoxic effects of HIV protein gp120 act through CXCR4 receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10905621&form=6&db=m Neuronal platelet-activating factor receptor signal transduction involves a pertussis toxin-sensitive G-protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10908303&form=6&db=m Complex involvement of pertussis toxin-sensitive G proteins in the regulation of type 1alpha metabotropic glutamate receptor signaling in baby hamster kidney cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10908315&form=6&db=m The D2s dopamine receptor stimulates phospholipase D activity: a novel signaling pathway for dopamine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10908568&form=6&db=m G protein-coupled receptor-induced sensitization of phospholipase C stimulation by receptor tyrosine kinases. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10908599&form=6&db=m A voltage-independent calcium current inhibitory pathway activated by muscarinic agonists in rat sympathetic neurons requires both Galpha q/11 and Gbeta gamma. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10908734&form=6&db=m kappa-Opioid inhibits catecholamine biosynthesis in PC12 rat pheochromocytoma cell. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10910113&form=6&db=m Second messenger pathways involved in up-regulation of an L-type calcium channel. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10910608&form=6&db=m Effect of local massage on vaccination: DTP and DTPa. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10913016&form=6&db=m Hypertrophic effect of selective beta(1)-adrenoceptor stimulation on ventricular cardiomyocytes from adult rat. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10913358&form=6&db=m V642I APP-inducible neuronal cells: a model system for investigating Alzheimer's disorders. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10913388&form=6&db=m Frequency of serological evidence of Bordetella infections and mixed infections with other respiratory pathogens in university students with cough illnesses. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10913389&form=6&db=m Antibody responses to Bordetella pertussis antigens and clinical correlations in elderly community residents. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10913917&form=6&db=m Arachidonic acid for loading induced prostacyclin and prostaglandin E(2) release from osteoblasts and osteocytes is derived from the activities of different forms of phospholipase A(2). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10915638&form=6&db=m Biological activities of novel lipid mediator sphingosine 1-phosphate in rat hepatic stellate cells. causal interaction,diagnostic usage,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10915831&form=6&db=m The putative <> 5-HT(1A) receptor antagonist, WAY 100635, has inverse agonist properties at cloned human 5-HT(1A) receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10919265&form=6&db=m Characterization of neuropeptide Y-mediated corticotropin-releasing factor synthesis and release from human placental trophoblasts. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10921922&form=6&db=m Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10923478&form=6&db=m [Cloning and expression of subunit genes of pertussis toxin and its immunological evaluation] diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10924500&form=6&db=m Trimer carboxyl propeptide of collagen I produced by mature osteoblasts is chemotactic for endothelial cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10925302&form=6&db=m Human galectin-3 is a novel chemoattractant for monocytes and macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10925305&form=6&db=m Requirements for C5a receptor-mediated IL-4 and IL-13 production and leukotriene C4 generation in human basophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10926543&form=6&db=m G(s) protein dysfunction in allergen-challenged human isolated passively sensitized bronchi. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10929078&form=6&db=m Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of CD14 and urokinase receptor. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10930355&form=6&db=m Inhibition by SR 59119A of isoprenaline-, forskolin- and VIP-induced relaxation of human isolated bronchi. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10931131&form=6&db=m Booster immunization of children with an acellular pertussis vaccine enhances Th2 cytokine production and serum IgE responses against pertussis toxin but not against common allergens. diagnostic usage,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10931825&form=6&db=m Cell cycle-dependent coupling of the vasopressin V1a receptor to different G proteins. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10934205&form=6&db=m Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10934299&form=6&db=m Opioid analgesic-induced apoptosis and caspase-independent cell death in human lung carcinoma A549 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10935533&form=6&db=m Altered endothelium-dependent and -independent hyperpolarization and endothelium-dependent relaxation in carotid arteries isolated from streptozotocin-induced diabetic rats. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10936201&form=6&db=m Coupling of canine serotonin 5-HT(1B) and 5-HT(1D) receptor subtypes to the formation of inositol phosphates by dual interactions with endogenous G(i/o) and recombinant G(alpha15) proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10936212&form=6&db=m Site-directed mutations in the third intracellular loop of the serotonin 5-HT(1A) receptor alter G protein coupling from G(i) to G(s) in a ligand-dependent manner. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10937466&form=6&db=m Diphtheria-tetanus-acellular pertussis vaccine adsorbed (Triacelluvax; DTaP3-CB): a review of its use in the prevention of Bordetella pertussis infection. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10940934&form=6&db=m The enhanced antigen-specific production of cytokines induced by pertussis toxin is due to clonal expansion of T cells and not to altered effector functions of long-term memory cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10942724&form=6&db=m Multiple receptor activation elicits synergistic IP formation in nonpigmented ciliary body epithelial cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10942792&form=6&db=m Sphingosine 1-phosphate stimulates G(i)- and Rho-mediated vascular endothelial cell spreading and migration. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10943406&form=6&db=m Molecular aspects of Bordetella pertussis pathogenesis. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10943863&form=6&db=m Human chondrocytes express functional chemokine receptors and release matrix-degrading enzymes in response to C-X-C and C-C chemokines. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10945848&form=6&db=m Alterations in G-proteins and beta-adrenergic responsive adenylyl cyclase in rat urinary bladder during aging. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10945862&form=6&db=m Synergistic stimulation of airway smooth muscle cell mitogenesis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10946302&form=6&db=m Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10947064&form=6&db=m Trafficking of neutrophils across airway epithelium is dependent upon both thioredoxin- and pertussis toxin-sensitive signaling mechanisms. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10947803&form=6&db=m VIP and PACAP potentiation of nicotinic ACh-evoked currents in rat parasympathetic neurons is mediated by G-protein activation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10948100&form=6&db=m Recombinant Mycobacterium bovis BCG expressing pertussis toxin subunit S1 induces protection against an intracerebral challenge with live Bordetella pertussis in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10952677&form=6&db=m Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10952678&form=6&db=m Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10953041&form=6&db=m Stimulation of sphingosine-1-phosphate formation by the P2Y(2) receptor in HL-60 cells: Ca(2+) requirement and implication in receptor-mediated Ca(2+) mobilization, but not MAP kinase activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10953055&form=6&db=m Pertussis toxin inhibits cholecystokinin- and epidermal growth factor-induced mitogen-activated protein kinase activation by disinhibition of the cAMP signaling pathway and inhibition of c-Raf-1. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10954581&form=6&db=m The B-oligomer of pertussis toxin inhibits human immunodeficiency virus type 1 replication at multiple stages. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10960077&form=6&db=m Mechanisms of the thapsigargin-induced Ca(2+) entry in in situ endothelial cells of the porcine aortic valve and the endothelium-dependent relaxation in the porcine coronary artery. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10964542&form=6&db=m N36, a synthetic N-terminal heptad repeat domain of the HIV-1 envelope protein gp41, is an activator of human phagocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10964659&form=6&db=m Reducing agents and light break an S-S bond activating rhodopsin in vivo in Chlamydomonas. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10964699&form=6&db=m The calcium-sensing receptor stimulates JNK in MDCK cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10964909&form=6&db=m Macrophage colony-stimulating factor rapidly enhances beta-migrating very low density lipoprotein metabolism in macrophages through activation of a Gi/o protein signaling pathway. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10967545&form=6&db=m Membrane signaling and progesterone in female and male osteoblasts. II. Direct involvement of G alpha q/11 coupled to PLC-beta 1 and PLC-beta 3. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10971136&form=6&db=m Role of protein kinase C in mediating alpha-1-adrenoceptor-induced negative inotropic response in rat ventricles. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10972980&form=6&db=m Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10973995&form=6&db=m Endothelial cell-surface gp60 activates vesicle formation and trafficking via G(i)-coupled Src kinase signaling pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10974307&form=6&db=m Activation of group I metabotropic glutamate receptors induces long-term depression at sensory synapses in superficial spinal dorsal horn. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10974334&form=6&db=m Reversal of pertussis toxin-induced thermal allodynia by muscarinic cholinergic agonists in mice. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10974648&form=6&db=m Relief from glucose-induced over-stimulation sensitizes the adenylate cyclase-cAMP system of rat pancreatic islets. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10979896&form=6&db=m Pertussis toxin sensitization alters the pathogenesis of subsequent respiratory syncytial virus infection. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10979938&form=6&db=m Filamentous hemagglutinin and pertussis toxin from Bordetella pertussis modulate immune responses to unrelated antigens. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10979965&form=6&db=m Human recombinant histamine-releasing factor activates human eosinophils and the eosinophilic cell line, AML14-3D10. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10980258&form=6&db=m Endogenous cannabinoid anandamide directly inhibits voltage-dependent Ca(2+) fluxes in rabbit T-tubule membranes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10980263&form=6&db=m The stimulation of beta(3)-adrenoceptor causes phosphorylation of extracellular signal-regulated kinases 1 and 2 through a G(s)- but not G(i)-dependent pathway in 3T3-L1 adipocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10981219&form=6&db=m [Immunogenicity and safety of Di-Te-Ki-Pol vaccine "SSI" in Danish infants] causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10984624&form=6&db=m Blockade by pertussis toxin of the opioid effect on guinea pig ileum. Contractility and electrophysiological neuronal recording. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10985779&form=6&db=m G protein beta 5 subunit interactions with alpha subunits and effectors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10987834&form=6&db=m Thrombin-induced activation of cultured rodent microglia. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10987837&form=6&db=m Protein phosphatase 1 and 2A inhibitors prolong the switch in the control of glutamate release by group I metabotropic glutamate receptors: characterization of the inhibitory pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10989282&form=6&db=m Melatonin-induced organelle movement in melanophores is coupled to tyrosine phosphorylation of a high molecular weight protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10989284&form=6&db=m Evidence for transduction of mu but not kappa opioid modulation of extracellular signal-regulated kinase activity by G(z) and G(12) proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10989285&form=6&db=m Activation of particulate guanylate cyclase by adrenomedullin in cultured SV-40 transformed cat iris sphincter smooth muscle (SV-CISM-2) cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10991975&form=6&db=m G(z) can mediate the acute actions of mu- and kappa-opioids but is not involved in opioid-induced adenylyl cyclase supersensitization. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10993890&form=6&db=m Proteinase-activated receptor-1 regulation of macrophage elastase (MMP-12) secretion by serine proteinases. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10995774&form=6&db=m Phentolamine inhibits exocytosis of glucagon by Gi2 protein-dependent activation of calcineurin in rat pancreatic alpha -cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10999952&form=6&db=m The CB(1) cannabinoid receptor is coupled to the activation of c-Jun N-terminal kinase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11003574&form=6&db=m Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11005662&form=6&db=m G-protein coupled progesterone receptors in the plasma membrane of fungus Rhizopus nigricans. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11006986&form=6&db=m PTX-sensitive and -insensitive synaptic modulation at the frog neuromuscular junction. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11009431&form=6&db=m Adenosine A(2a)-receptor activation increases contractility in isolated perfused hearts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11009469&form=6&db=m Role of pertussis toxin-sensitive G protein in metabolic vasodilation of coronary microcirculation. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11009470&form=6&db=m Relationship of molecular structure to the mechanism of lysophospholipid-induced smooth muscle cell proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11015312&form=6&db=m The effect of Gi-protein inactivation on basal, and beta(1)- and beta(2)AR-stimulated contraction of myocytes from transgenic mice overexpressing the beta(2)-adrenoceptor. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11015314&form=6&db=m Effects of (+)-pentazocine and 1,3-di-o-tolylguanidine (DTG), sigma (sigma) ligands, on micturition in anaesthetized rats. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11016660&form=6&db=m Mechanism for the antitumor and anticachectic effects of n-3 fatty acids. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11018034&form=6&db=m beta 2-adrenergic receptor-induced p38 MAPK activation is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11021985&form=6&db=m Involvement of cAMP-dependent protein kinase and pertussis toxin-sensitive G-proteins in CGRP mediated JNK activation in human neuroblastoma cell line. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11022134&form=6&db=m SDF-1-induced activation of ERK enhances HIV-1 expression. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11022968&form=6&db=m Mechanisms of alpha,beta-methylene atp-induced inhibition in rat ileal smooth muscle: involvement of intracellular Ca2+ stores in purinergic inhibition. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11023463&form=6&db=m Polymorphism in Bordetella pertussis pertactin and pertussis toxin virulence factors in the United States, 1935-1999. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11024008&form=6&db=m The terminal complement complex C5b-9 stimulates interleukin-6 production in human smooth muscle cells through activation of transcription factors NF-kappa B and AP-1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11024260&form=6&db=m Co-expression of the Bordetella pertussis leader peptidase I results in enhanced processing and expression of the pertussis toxin S1 subunit in Escherichia coli. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11025445&form=6&db=m Independent activation of endogenous p21-activated protein kinase-3 (PAK3) and JNK by thrombin in CCL39 fibroblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11027221&form=6&db=m G-Protein types involved in calcium channel inhibition at a presynaptic nerve terminal. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11027718&form=6&db=m Abscisic acid stimulation of phospholipase D in the barley aleurone is G-protein-mediated and localized to the plasma membrane. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11029407&form=6&db=m Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i). causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11029623&form=6&db=m Differential modulation of rod and cone calcium currents in tiger salamander retina by D2 dopamine receptors and cAMP. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11029753&form=6&db=m Enhancement by sphingosine 1-phosphate in vasopressin-induced phosphoinositide hydrolysis in aortic smooth-muscle cells: involvement of p38 MAP kinase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11030712&form=6&db=m Adenosine A(1) receptor stimulation inhibits alpha(1)-adrenergic activation of the cardiac sarcolemmal Na(+)/H(+) exchanger. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11032896&form=6&db=m Coexpression of several types of metabotropic nucleotide receptors in single cerebellar astrocytes. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11032898&form=6&db=m Electrically evoked release of [(3)H]noradrenaline from mouse cultured sympathetic neurons: release-modulating heteroreceptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11034994&form=6&db=m Helicobacter pylori-induced prostaglandin E(2) synthesis involves activation of cytosolic phospholipase A(2) in epithelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11035102&form=6&db=m The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met is a potent chemotactic agonist for mouse formyl peptide receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11035208&form=6&db=m Complete inhibition of purinoceptor agonist-induced nociception by spinorphin, but not by morphine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11036869&form=6&db=m Sphingosine 1-phosphate stimulates insulin secretion in HIT-T 15 cells and mouse islets. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11040056&form=6&db=m Influence of receptor number on functional responses elicited by agonists acting at the human adenosine A(1) receptor: evidence for signaling pathway-dependent changes in agonist potency and relative intrinsic activity. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11041451&form=6&db=m The thyrotropin receptor is not involved in the activation of p42/p44 mitogen-activated protein kinases by thyrotropin preparations in Chinese hamster ovary cells expressing the human thyrotropin receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11042169&form=6&db=m Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma /Janus kinase 2/MEK-1-dependent pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11042263&form=6&db=m Evidence for the dual coupling of the rat neurotensin receptor with pertussis toxin-sensitive and insensitive G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11043551&form=6&db=m Deciphering the role of Gi2 in opioid-induced adenylyl cyclase supersensitization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11046012&form=6&db=m Functional differences between monocyte chemotactic protein-1 receptor A and monocyte chemotactic protein-1 receptor B expressed in a Jurkat T cell. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11046037&form=6&db=m The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11046061&form=6&db=m The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11048768&form=6&db=m Can immunization affect the development of allergy? therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11050109&form=6&db=m Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11050179&form=6&db=m Endogenous regulators of G protein signaling proteins regulate presynaptic inhibition at rat hippocampal synapses. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11053220&form=6&db=m Extracellular signal-regulated kinase 1/2 control Ca(2+)-independent force development in histamine-stimulated bovine tracheal smooth muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11053247&form=6&db=m Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11054382&form=6&db=m Group I secreted PLA2 in the maintenance of human lower esophageal sphincter tone. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11056155&form=6&db=m G(i)-mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine 1-phosphate: possible involvement in cell motility enhancement in cooperation with Rho-mediated pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11056210&form=6&db=m Different stimulatory opioid effects on intracellular Ca(2+) in SH-SY5Y cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11058876&form=6&db=m Extracellular lipid-mediated signaling in tumor-cell activation and pseudopod protrusion. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11061948&form=6&db=m Essential role for G proteins in prostate cancer cell growth and signaling. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11062066&form=6&db=m Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11062074&form=6&db=m Dominance of G(s) in doubly G(s)/G(i)-coupled chimaeric A(1)/A(2A) adenosine receptors in HEK-293 cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11062237&form=6&db=m N-methyl D-aspartate receptor-mediated bidirectional control of extracellular signal-regulated kinase activity in cortical neuronal cultures. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11063818&form=6&db=m Screening of several H-2 congenic mouse strains identified H-2(q) mice as highly susceptible to MOG-induced EAE with minimal adjuvant requirement. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11063823&form=6&db=m Interleukin-1beta-dependent changes in the hippocampus following parenteral immunization with a whole cell pertussis vaccine. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11065223&form=6&db=m Comparison of endothelium-dependent relaxation in carotid arteries from Japanese white and Watanabe heritable hyperlipidemic rabbits. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11066068&form=6&db=m Fertilization promoting peptide and adenosine, acting as first messengers, regulate cAMP production and consequent protein tyrosine phosphorylation in a capacitation-dependent manner. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11068030&form=6&db=m Intradermal application of nociceptin increases vascular permeability in rats: the possible involvement of histamine release from mast cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11068150&form=6&db=m Endothelins increase tyrosine phosphorylation of astrocytic focal adhesion kinase and paxillin accompanied by their association with cytoskeletal components. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11069896&form=6&db=m Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11069947&form=6&db=m Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11073105&form=6&db=m Monoclonal Lym-1 antibody-targeted lysis of B lymphoma cells by neutrophils. Evidence for two mechanisms of FcgammaRII-dependent cytolysis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11073961&form=6&db=m Agonist-induced phosphorylation of somatostatin receptor subtype 1 (sst1). Relationship to desensitization and internalization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11078878&form=6&db=m Enhanced epinephrine-induced platelet aggregation in individuals carrying the G protein beta3 subunit 825T allele. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11081334&form=6&db=m [Acellular pertussis vaccines--safe alternative] causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11082154&form=6&db=m Angiotensin II type 2 receptors stimulate collagen synthesis in cultured vascular smooth muscle cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11082457&form=6&db=m S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11083899&form=6&db=m Activation of A(3) adenosine receptor induces calcium entry and chloride secretion in A(6) cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11084020&form=6&db=m Conformational dependence of collagenase (matrix metalloproteinase-1) up-regulation by elastin peptides in cultured fibroblasts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11086221&form=6&db=m Insulinotropic toxins as molecular probes for analysis of glucagon-likepeptide-1 receptor-mediated signal transduction in pancreatic beta-cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11087813&form=6&db=m The transcriptional responses of respiratory epithelial cells to Bordetella pertussis reveal host defensive and pathogen counter-defensive strategies. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11090105&form=6&db=m Pertussis toxin-sensitive G(i)-proteins and intracellular calcium sensitivity of vasoconstriction in the intact rat tail artery. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11090715&form=6&db=m Investigation of cellular and humoral immune responses to whole cell and acellular pertussis vaccines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11094274&form=6&db=m The Bvg accessory factor (Baf) enhances pertussis toxin expression in Escherichia coli and is essential for Bordetella pertussis viability. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11095474&form=6&db=m Multiple signal transduction pathways through two prostaglandin E receptor EP3 subtype isoforms expressed in human uterus. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11095495&form=6&db=m The effect of CNTF on glutamate-induced increases in intracellular free Ca2+ in hippocampal neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11095961&form=6&db=m Neuronal cell apoptosis by a receptor-binding domain peptide of ApoE4, not through low-density lipoprotein receptor-related protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11098120&form=6&db=m The G-protein inhibitor, pertussis toxin, inhibits the secretion of brain-derived neurotrophic factor. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11099401&form=6&db=m Mitogenic action of lysophosphatidic acid in proximal tubular epithelial cells obtained from voided human urine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11099498&form=6&db=m Regulation of Rac and Cdc42 pathways by G(i) during lysophosphatidic acid-induced cell spreading. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11099701&form=6&db=m Increased plasma corticosterone, aggressiveness and brain monoamine changes induced by central injection of pertussis toxin. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11104510&form=6&db=m P0 protein peptide 180-199 together with pertussis toxin induces experimental autoimmune neuritis in resistant C57BL/6 mice. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11104827&form=6&db=m The CXCR4 agonist ligand stromal derived factor-1 maintains high affinity for receptors in both Galpha(i)-coupled and uncoupled states. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11108276&form=6&db=m The acute and chronic stimulatory effects of endothelin-1 on glucose transport are mediated by distinct pathways in 3T3-L1 adipocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11108815&form=6&db=m Increased sensitivity of neonate atrial myocytes to adenosine A1 receptor stimulation in regulation of the L-type Ca2+ current. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11108818&form=6&db=m Changes in intracellular Ca2+ by activation of P2 receptors in submucosal neurons in short-term cultures. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11108996&form=6&db=m Nociceptin is a potent inhibitor of N-type Ca(2+) channels in rat sympathetic ganglion neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11110775&form=6&db=m The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11111902&form=6&db=m Genomics of Bordetella pertussis toxins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11111919&form=6&db=m Intracellular trafficking and membrane translocation of pertussis toxin into host cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11112429&form=6&db=m Characterization of a zebrafish (Danio rerio) sphingosine 1-phosphate receptor expressed in the embryonic brain. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11113634&form=6&db=m Stimulation of cannabinoid receptor agonist 2-arachidonylglycerol by chronic ethanol and its modulation by specific neuromodulators in cerebellar granule neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11115714&form=6&db=m Immunogenicity of a hexavalent combination vaccine in rhesus monkeys. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11116326&form=6&db=m Structural evidence for the evolution of pyrogenic toxin superantigens. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11120746&form=6&db=m Coupling of the insulin-like growth factor-I receptor tyrosine kinase to Gi2 in human intestinal smooth muscle: Gbetagamma -dependent mitogen-activated protein kinase activation and growth. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11120783&form=6&db=m Cutting edge: C-C chemokine receptor 6 is essential for arrest of a subset of memory T cells on activated dermal microvascular endothelial cells under physiologic flow conditions in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11120854&form=6&db=m Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11123341&form=6&db=m IL-8 induces a transient arrest of rolling eosinophils on human endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11124161&form=6&db=m Differential alterations in cardiac adrenergic signaling in chronic hypoxia or norepinephrine infusion. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11124829&form=6&db=m Signal pathway involved in the development of hypoxic preconditioning in rat hepatocytes. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11125021&form=6&db=m SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11125027&form=6&db=m A3 adenosine receptor activation triggers phosphorylation of protein kinase B and protects rat basophilic leukemia 2H3 mast cells from apoptosis. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11125031&form=6&db=m Dopamine D2 receptor regulation of the dopamine transporter expressed in Xenopus laevis oocytes is voltage-independent. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11125036&form=6&db=m Ethanol acts synergistically with a D2 dopamine agonist to cause translocation of protein kinase C. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11125860&form=6&db=m Effects of pertussis toxin on behavioral responses during different withdrawal periods from chronic cocaine treatment. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11125887&form=6&db=m Direct role of plasma membrane-expressed gp120/41 in toxicity to human astrocytes induced by HIV-1-infected macrophages. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11129652&form=6&db=m Activation of human neutrophils by the plant lectin Viscum album agglutinin-I: modulation of de novo protein synthesis and evidence that caspases are involved in induction of apoptosis. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11133354&form=6&db=m Cyclic AMP regulates the calcium transients released from IP(3)-sensitive stores by activation of rat kappa-opioid receptors expressed in CHO cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11133740&form=6&db=m The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11133947&form=6&db=m Genetic and biochemical analyses of BvgA interaction with the secondary binding region of the fha promoter of Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11134047&form=6&db=m Sphingosine 1-phosphate protects human umbilical vein endothelial cells from serum-deprived apoptosis by nitric oxide production. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11135250&form=6&db=m Comparison of the timing of acute blood-brain barrier breakdown to rabbit immunoglobulin G in the cerebellum and spinal cord of mice with experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11135703&form=6&db=m Systemic allergic reactions to gelatin included in vaccines as a stabilizer. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11137247&form=6&db=m Protection and humoral immune responses against Bordetella pertussis infection in mice immunized with acellular or cellular pertussis immunogens. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11137257&form=6&db=m Efficacy of chemically cross-linked antigens for acellular pertussis vaccine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11137258&form=6&db=m Efficacy of pertussis vaccines consisted of antigens detoxified with tea-leaf catechins. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11141237&form=6&db=m Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11141326&form=6&db=m Activation of human neutrophils by technical toxaphene. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11145933&form=6&db=m 8-Iso-PGF2 alpha induces beta 2-integrin-mediated rapid adhesion of human polymorphonuclear neutrophils: a link between oxidative stress and ischemia/reperfusion injury. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11146117&form=6&db=m Differential roles of Edg-1 and Edg-5, sphingosine 1-phosphate receptors, in the signaling pathways in C6 glioma cells. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11146399&form=6&db=m Signalling pathways activated by 5-HT(1B)/5-HT(1D) receptors in native smooth muscle and primary cultures of rabbit renal artery smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11146421&form=6&db=m Neurotensin modulates the electrical activity of frog pituitary melanotropes via activation of a G-protein-coupled receptor pharmacologically related to both the NTS1 and nts2 receptors of mammals. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11154207&form=6&db=m Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11154209&form=6&db=m Signal transduction involved in MCP-1-mediated monocytic transendothelial migration. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11156568&form=6&db=m Effects of tyrosine kinase inhibitors on cell death induced by sodium fluoride and pertussis toxin in the pancreatic beta-cell line, RINm5F. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11156575&form=6&db=m Activity of adenosine diphosphates and triphosphates on a P2Y(T) -type receptor in brain capillary endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11156962&form=6&db=m Prosaposin treatment induces PC12 entry in the S phase of the cell cycle and prevents apoptosis: activation of ERKs and sphingosine kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11158213&form=6&db=m Protein kinase C and G(i/o) proteins are involved in adenosine- and ischemic preconditioning-mediated renal protection. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11158499&form=6&db=m Reactogenicity and immunogenicity at preschool age of a booster dose of two three-component diphtheria-tetanus-acellular pertussis vaccines in children primed in infancy with acellular vaccines. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11159049&form=6&db=m Regulation of G protein-coupled receptor-adenylyl cyclase responsiveness in human airway smooth muscle by exogenous and autocrine adenosine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11159687&form=6&db=m Two subtypes of G protein-coupled nucleotide receptors, P2Y(1) and P2Y(2) are involved in calcium signalling in glioma C6 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11159694&form=6&db=m Evidence for cocaine and methylecgonidine stimulation of M(2) muscarinic receptors in cultured human embryonic lung cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11159729&form=6&db=m Somatostatin receptor-mediated arachidonic acid mobilization: evidence for partial agonism of synthetic peptides. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11159838&form=6&db=m Stimulation of mitogen-activated protein kinase by gonadotropin-releasing hormone in human granulosa-luteal cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11160154&form=6&db=m Fibroblast-like synoviocytes support B-cell pseudoemperipolesis via a stromal cell-derived factor-1- and CD106 (VCAM-1)-dependent mechanism. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11160182&form=6&db=m The neurotoxic prion peptide fragment PrP(106-126) is a chemotactic agonist for the G protein-coupled receptor formyl peptide receptor-like 1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11160184&form=6&db=m Expression of the C-C chemokine receptor CCR3 in human airway epithelial cells. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11160233&form=6&db=m The binding subunit of pertussis toxin inhibits HIV replication in human macrophages and virus expression in chronically infected promonocytic U1 cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11160627&form=6&db=m The thromboxane A2 receptor activates mitogen-activated protein kinase via protein kinase C-dependent Gi coupling and Src-dependent phosphorylation of the epidermal growth factor receptor. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11161002&form=6&db=m Melanocortin receptor-mediated mobilization of intracellular free calcium in HEK293 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11162186&form=6&db=m Pasteurella (Mannheimia) haemolytica leukotoxin-induced cytolysis of bovine leukocytes: role of arachidonic acid and its regulation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11162649&form=6&db=m Effects of phosphotyrosine phosphatase inhibition on insulin secretion and intracellular signaling events in rat pancreatic islets. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11163355&form=6&db=m C3A binds to the seven transmembrane anaphylatoxin receptor expressed by epithelial cells and triggers the production of IL-8. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11165228&form=6&db=m Pharmacological actions of AH-9700 on micturition reflex in anesthetized rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11165768&form=6&db=m Pertussis toxin does not affect the time course of quantal release in crayfish and mouse muscle, but has other post- and presynaptic effects, especially on adenosine autoreceptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11166122&form=6&db=m 5-HT(7) receptors activate the mitogen activated protein kinase extracellular signal related kinase in cultured rat hippocampal neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11166929&form=6&db=m Opioid-induced adenylyl cyclase supersensitization in human embryonic kidney 293 cells requires pertussis toxin-sensitive G proteins other than G(i1) and G(i3). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11168001&form=6&db=m Inflammatory activation of neutrophils by Helicobacter pylori; a mechanism insensitive to pertussis toxin. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11168387&form=6&db=m CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11168391&form=6&db=m delta(9)-Tetrahydrocannabinol increases nerve growth factor production by prostate PC-3 cells. Involvement of CB1 cannabinoid receptor and Raf-1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11169404&form=6&db=m The chemokine receptor CXCR4 is expressed within the mast cell lineage and its ligand stromal cell-derived factor-1alpha acts as a mast cell chemotaxin. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11169771&form=6&db=m Mechanisms of adenosine 5'-triphosphate-induced dopamine release in the rat nucleus accumbens in vivo. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11169789&form=6&db=m Basal levels of adenosine modulate mGluR5 on rat hippocampal astrocytes. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11170183&form=6&db=m Pertussis toxin-sensitive G-protein and protein kinase C activity are involved in normal synapse elimination in the neonatal rat muscle. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11170844&form=6&db=m Antibody-induced activation of beta1 integrin receptors stimulates cAMP-dependent migration of breast cells on laminin-5. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11171390&form=6&db=m Cell surface beta-1,4-galactosyltransferase-I activates G protein-dependent exocytotic signaling. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11171676&form=6&db=m Demonstration of mast cell chemotactic activity in synovial fluid from rheumatoid patients. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11171998&form=6&db=m Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11172816&form=6&db=m ADP receptor antagonists inhibit platelet aggregation induced by the chemokines SDF-1, MDC and TARC. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11174001&form=6&db=m High glucose stimulates Ca2+ uptake via cAMP and PLC/PKC pathways in primary cultured renal proximal tubule cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11174714&form=6&db=m In vitro complement activation favoring soluble C5b-9 complex formation alters myocellular sodium homeostasis. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11174797&form=6&db=m G-protein expression and intimal hyperplasia after arterial injury: a role for Galpha(i) proteins. diagnostic usage,ongoing research,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11175801&form=6&db=m Chemokines as regulators of T cell differentiation. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179394&form=6&db=m Signal transduction of cannabinoid CB1 receptors in a smooth muscle cell line. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179396&form=6&db=m G protein-mediated inhibitory effect of a nitric oxide donor on the L-type Ca2+ current in rat ventricular myocytes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179453&form=6&db=m Angiotensin AT(1) receptor phosphorylation and desensitization in a hepatic cell line. Roles of protein kinase c and phosphoinositide 3-kinase. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179773&form=6&db=m Cholera and pertussis toxins inhibit differently hypothermic and anti-opioid effects of neuropeptide FF. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11180400&form=6&db=m Role of pertussis toxin-sensitive G-proteins in intracellular Ca2+ release and apoptosis induced by inhibiting cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels in HepG2 human hepatoblastoma cells. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11180982&form=6&db=m Naphazoline-induced suppression of aqueous humor pressure and flow: involvement of central and peripheral alpha(2)/I(1) receptors. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11181023&form=6&db=m Beta-adrenergic cardiac hypertrophy is mediated primarily by the beta(1)-subtype in the rat heart. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11181524&form=6&db=m Lysophosphatidic acid is an osteoblast mitogen whose proliferative actions involve G(i) proteins and protein kinase C, but not P42/44 mitogen-activated protein kinases. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11181537&form=6&db=m Mechanisms of phospholipase C activation by the vasoactive intestinal polypeptide/pituitary adenylate cyclase-activating polypeptide type 2 receptor. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11185956&form=6&db=m Sphingosine 1-phosphate activates Erk-1/-2 by transactivating epidermal growth factor receptor in rat-2 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11191828&form=6&db=m Different alpha1-adrenoceptor-induced inositol phosphate formation in the two portions of rat vas deferens. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11191829&form=6&db=m Alpha2-adrenoceptor-mediated inhibition of cultured sympathetic neurons: changes in alpha2A/D-adrenoceptor-deficient mice. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11192364&form=6&db=m Hyperpolarization is not responsible for the acetylcholine-induced negative chronotropic action in the presence of isoproterenol. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11202610&form=6&db=m Effects of S-nitroso-cysteine on proteins that regulate exocytosis in PC12 cells: inhibitory effects on translocation of synaptophysin and ADP-ribosylation of GTP-binding proteins. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11207619&form=6&db=m Expression, activity and cytotoxicity of pertussis toxin S1 subunit in transfected mammalian cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11208605&form=6&db=m Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11214235&form=6&db=m Physicochemical characterisation of the pertussis vaccine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11219402&form=6&db=m H3 receptor-mediated inhibition of intestinal acetylcholine release: pharmacological characterization of signal transduction pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11222381&form=6&db=m Thymic emigrants isolated by a new method possess unique phenotypic and functional properties. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11222744&form=6&db=m Regulation of Ca2+-sensitive adenylyl cyclase in gonadotropin-releasing hormone neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11223424&form=6&db=m Lipid peroxidation product 4-hydroxy-2-nonenal acts synergistically with serotonin in inducing vascular smooth muscle cell proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11223431&form=6&db=m Low-density lipoprotein (LDL) binds to a G-protein coupled receptor in human platelets. Evidence that the proaggregatory effect induced by LDL is modulated by down-regulation of binding sites and desensitization of its mediated signaling. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11226383&form=6&db=m Lack of involvement of pertussis toxin-sensitive G-proteins in norepinephrine-induced vasoconstriction of rat aorta smooth muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11226388&form=6&db=m Regulation of p42/p44 MAPK and p38 MAPK by the adenosine A(1) receptor in DDT(1)MF-2 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11226389&form=6&db=m Leukotriene D(4)-induced Rho-mediated actin reorganization in human bronchial smooth muscle cells. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11232027&form=6&db=m Role of mitogen-activated protein kinase in prostaglandin f(2alpha) action in human granulosa-luteal cells. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11236575&form=6&db=m [Identification and isolation of GTP-binding regulator protein from plasma membranes of oocytes from the starfish Asterias amurensis] causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11238275&form=6&db=m Serotonin-induced hypercontraction through 5-hydroxytryptamine 1B receptors in atherosclerotic rabbit coronary arteries. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11238741&form=6&db=m Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11239914&form=6&db=m Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11243883&form=6&db=m Enhancement of lysophosphatidic acid-induced ERK phosphorylation by phospholipase D1 via the formation of phosphatidic acid. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245606&form=6&db=m G protein coupling to M1 and M3 muscarinic receptors in sublingual glands. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245610&form=6&db=m PKD in intestinal epithelial cells: rapid activation by phorbol esters, LPA, and angiotensin through PKC. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245682&form=6&db=m Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11250872&form=6&db=m Dual effects of muscarinic M(2) acetylcholine receptors on the synthesis of cyclic AMP in CHO cells: dependence on time, receptor density and receptor agonists. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11250936&form=6&db=m Adenosine triphosphate activates mitogen-activated protein kinase in human granulosa-luteal cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11250949&form=6&db=m Estradiol signaling via sequestrable surface receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11254129&form=6&db=m Cytoplasmic kinase and phosphatase activities can induce PsaF gene expression in the absence of functional plastids: evidence that phosphorylation/dephosphorylation events are involved in interorganellar crosstalk. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11256956&form=6&db=m Proinsulin C-peptide rapidly stimulates mitogen-activated protein kinases in Swiss 3T3 fibroblasts: requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxin-sensitive G-protein. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11257120&form=6&db=m The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11257510&form=6&db=m Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Galpha(s) and Galpha(i)/Galpha(o) activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11259498&form=6&db=m The human delta opioid receptor activates G(i1)alpha more efficiently than G(o1)alpha. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11259610&form=6&db=m Nootropic drug modulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11259634&form=6&db=m Activation of guanosine 5'-[gamma-(35)S]thio-triphosphate binding through M(1) muscarinic receptors in transfected Chinese Hamster ovary cell membranes: 2. Testing the "two-states" model of receptor activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11260141&form=6&db=m Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11264247&form=6&db=m Mitogenic effect of oxidized low-density lipoprotein on vascular smooth muscle cells mediated by activation of Ras/Raf/MEK/MAPK pathway. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11264662&form=6&db=m P2Y receptor-mediated inhibition of voltage-activated Ca(2+) currents in PC12 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11266085&form=6&db=m CD8+ T cell suppressor factors and the control of infection, replication and transcription of human immunodeficiency virus. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11266507&form=6&db=m Beta(2)-adrenergic receptors potentiate glucocorticoid receptor transactivation via G protein beta gamma-subunits and the phosphoinositide 3-kinase pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11267996&form=6&db=m Mechanisms of P2 receptor-evoked DNA synthesis in thyroid FRTL-5 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11270638&form=6&db=m Interleukin-1beta-induced prostaglandin E2 production in human myometrial cells: role of a pertussis toxin-sensitive component. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11274763&form=6&db=m Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-dependent adhesion to fibronectin and VCAM-1 on bone marrow hematopoietic progenitor cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11274962&form=6&db=m Protective effects of morphine in peroxynitrite-induced apoptosis of primary rat neonatal astrocytes: potential involvement of G protein and phosphatidylinositol 3-kinase (PI3 kinase). therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11274979&form=6&db=m Possible involvement of G(i3) protein in augmented contraction of bronchial smooth muscle from antigen-induced airway hyperresponsive rats. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11275548&form=6&db=m The mouse putative pheromone receptor was specifically activated by stimulation with male mouse urine. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11275977&form=6&db=m The Rho/Rho-kinase and the phosphatidylinositol 3-kinase pathways are essential for spontaneous locomotion of Walker 256 carcinosarcoma cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278278&form=6&db=m Comodulation of CXCR4 and CD26 in human lymphocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278310&form=6&db=m Adenosine nucleotides acting at the human P2Y1 receptor stimulate mitogen-activated protein kinases and induce apoptosis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278341&form=6&db=m The Ca2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha -dependent ERK-independent pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278407&form=6&db=m Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278727&form=6&db=m Hypoxia-induced proliferative response of vascular adventitial fibroblasts is dependent on g protein-mediated activation of mitogen-activated protein kinases. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278738&form=6&db=m Rantes activates Jak2 and Jak3 to regulate engagement of multiple signaling pathways in T cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278760&form=6&db=m Bradykinin B2 receptors activate Na+/H+ exchange in mIMCD-3 cells via Janus kinase 2 and Ca2+/calmodulin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11279222&form=6&db=m Gbeta gamma mediate differentiation of vascular smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11280708&form=6&db=m Aging and calcitriol regulation of IP3 production in rat skeletal muscle and intestine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11282157&form=6&db=m Tolerance induction by acylated peptides: suppression of EAE in the mouse with palmitoylated PLP peptides. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11283226&form=6&db=m Direct autocrine inhibition and cAMP-dependent potentiation of single L-type Ca2+ channels in bovine chromaffin cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11286993&form=6&db=m Specific involvement of G(alphai2) with epidermal growth factor receptor signaling in rat hepatocytes, and the inhibitory effect of chronic ethanol. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11287092&form=6&db=m Neuropeptide Y Y2 receptor signalling mechanisms in the human glioblastoma cell line LN319. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11287327&form=6&db=m Intracellular Ca(2+) signaling in endothelial cells by the angiogenesis inhibitors endostatin and angiostatin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11287329&form=6&db=m Nongenomic effect of testosterone on chloride secretion in cultured rat efferent duct epithelia. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11287337&form=6&db=m Pertussis toxin directly activates endothelial cell p42/p44 MAP kinases via a novel signaling pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11292391&form=6&db=m Anti-adrenergic effect of adenosine on Na(+)-Ca(2+) exchange current recorded from guinea-pig ventricular myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11292623&form=6&db=m The calcium-sensing receptor regulates calcium absorption in MDCK cells by inhibition of PMCA. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11292726&form=6&db=m Reversal of the CD4(+)/CD8(+) T-cell ratio in lymph node cells upon in vitro mitogenic stimulation by highly purified, water-soluble S3-S4 dimer of pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11293667&form=6&db=m Differential activation of signal transduction pathways mediating phagocytosis, oxidative burst, and degranulation by chicken heterophils in response to stimulation with opsonized Salmonella enteritidis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11294666&form=6&db=m Population-based incidence of pertussis among adolescents and adults, Minnesota, 1995-1996. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11295169&form=6&db=m Endothelin-1 receptors on cultured rat articular chondrocytes: regulation by age, growth factors, and cytokines, and effect on cAMP production. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11295234&form=6&db=m The comparative analysis of proenkephalin mRNA expression induced by cholera toxin and pertussis toxin in primary cultured rat cortical astrocytes. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11298331&form=6&db=m Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11298841&form=6&db=m Changes in binding of iodomelatonin to membranes of Leydig cells and steroidogenesis after prolonged in vitro exposure to melatonin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11299208&form=6&db=m Pregnancy enhances G protein activation and nitric oxide release from uterine arteries. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11299302&form=6&db=m Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11301041&form=6&db=m Modulation of ligand responses by coupling of alpha(2A)-adrenoceptors to diverse G(alpha)-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11301051&form=6&db=m Role of G(i)-proteins in norepinephrine-mediated vasoconstriction in rat tail artery smooth muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11301058&form=6&db=m Neuropeptide FF receptors couple to a cholera toxin-sensitive G-protein in rat dorsal raphe neurones. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11301251&form=6&db=m Regulation of Xenopus oocyte meiosis arrest by G protein betagamma subunits. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11303021&form=6&db=m Characterization of a G protein-activated phosphoinositide 3-kinase in vascular smooth muscle cell nuclei. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11303026&form=6&db=m Cytoplasmic domain of natriuretic peptide receptor C constitutes Gi activator sequences that inhibit adenylyl cyclase activity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11303190&form=6&db=m Characterization of the biologic activities of a recombinant human zona pellucida protein 3 expressed in human ovarian teratocarcinoma (PA-1) cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11303728&form=6&db=m Signal transduction events in Chinese hamster ovary cells expressing human CD14; effect of endotoxin desensitization. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11306243&form=6&db=m Mechanisms of thrombin-induced MAPK activation associated with cell proliferation in human cultured tracheal smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11306654&form=6&db=m RGS2 blocks slow muscarinic inhibition of N-type Ca(2+) channels reconstituted in a human cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11306675&form=6&db=m The CB(1) cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fan. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11306682&form=6&db=m Role of protein kinase Calpha in signaling from the histamine H(1) receptor to the nucleus. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11306695&form=6&db=m High-intensity p38 kinase activity is critical for p21(cip1) induction and the antiproliferative function of G(i) protein-coupled receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11306711&form=6&db=m Agonist-dependent delivery of M(2) muscarinic acetylcholine receptors to the cell surface after pertussis toxin treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11306977&form=6&db=m Aminooxypentane-RANTES induces CCR3 activation and internalization of CCR3 from the surface of human eosinophils. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11309265&form=6&db=m Lysosphingolipid receptor-mediated diuresis and natriuresis in anaesthetized rats. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11310854&form=6&db=m Signal transduction pathways for activation of extracellular signal-regulated kinase by arachidonic acid in rat neutrophils. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11310855&form=6&db=m MCP-1 receptor binding affinity is up-regulated by pre-stimulation with MCP-1 in an actin polymerization-dependent manner. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11311892&form=6&db=m Cell type-specific differences in the coupling of recombinant mGlu1alpha receptors to endogenous G protein sub-populations. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11311898&form=6&db=m Tetrahydrocannabinol-induced apoptosis of cultured cortical neurones is associated with cytochrome c release and caspase-3 activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11312009&form=6&db=m Immunogenicity and reactogenicity of a single dose of a diphtheria--tetanus--acellular pertussis component vaccine (DTaP) compared to a diphtheria--tetanus toxoid (Td) and a diphtheria toxoid vaccine (d) in adults. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11312279&form=6&db=m Kainate receptors depress excitatory synaptic transmission at CA3-->CA1 synapses in the hippocampus via a direct presynaptic action. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11312281&form=6&db=m Ionotropic histamine receptors and H2 receptors modulate supraoptic oxytocin neuronal excitability and dye coupling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11312566&form=6&db=m Regeneration of entorhinal fibers in mouse slice cultures is age dependent and can be stimulated by NT-4, GDNF, and modulators of G-proteins and protein kinase C. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11313421&form=6&db=m Rapid depletion of peripheral antigen-specific T cells in TCR-transgenic mice after oral administration of myelin basic protein. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11313442&form=6&db=m Presynaptic mechanisms underlying cannabinoid inhibition of excitatory synaptic transmission in rat striatal neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11313909&form=6&db=m G(z) signaling: emerging divergence from G(i) signaling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11315999&form=6&db=m Endogenous prostaglandin E2 and insulin-like growth factor 1 can modulate the levels of parathyroid hormone receptor in human osteoarthritic osteoblasts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11316806&form=6&db=m Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11319726&form=6&db=m Vascular insulin/insulin-like growth factor-1 resistance in female obese Zucker rats. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11322932&form=6&db=m A dual role of protein kinase C in insulin signal transduction via adenylyl cyclase signaling system in muscle tissues of vertebrates and invertebrates. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11324523&form=6&db=m [The role of G protein, protein kinase C and Na(+)-H+ exchanger in endothelin-1-induced cardiomyocyte hypertrophic responses] causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11324579&form=6&db=m [Pathways of signal transduction of intracellular Ca2+ increase mediated by three subtypes of alpha 1-adrenoceptor in HEK293 cells] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11325013&form=6&db=m Molecular mechanisms for alpha2-adrenoceptor-mediated regulation of synoviocyte populations. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11325803&form=6&db=m Functional characterization of a human receptor for neuropeptide FF and related peptides. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11328586&form=6&db=m Activation by 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, of p42/44 mitogen-activated protein kinase in HL-60 cells. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11331301&form=6&db=m An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11332608&form=6&db=m Cyclic tensile stretch inhibition of nitric oxide release from osteoblast-like cells is both G protein and actin-dependent. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11336796&form=6&db=m Receptor-independent effects of natural cannabinoids in rat peritoneal mast cells in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11341512&form=6&db=m High density lipoproteins induce cell cycle entry in vascular smooth muscle cells via mitogen activated protein kinase-dependent pathway. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11341968&form=6&db=m Regulation of phospholipase D (PLD) in growth plate chondrocytes by 24R,25-(OH)2D3 is dependent on cell maturation state (resting zone cells) and is specific to the PLD2 isoform. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11341973&form=6&db=m N1E-115 mouse neuroblastoma cells express MT1 melatonin receptors and produce neurites in response to melatonin. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11342226&form=6&db=m Identification of a murine cysteinyl leukotriene receptor by expression in Xenopus laevis oocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11342388&form=6&db=m Functional domains of delta- and mu-opioid receptors responsible for adenylyl cyclase inhibition. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11342460&form=6&db=m Rapid and efficient homing of human CD34(+)CD38(-/low)CXCR4(+) stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m(null) mice. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11343686&form=6&db=m Direct inhibition of voltage-dependent Ca(2+) fluxes by ethanol and higher alcohols in rabbit T-tubule membranes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11344352&form=6&db=m Effects of purine and pyrimidine nucleotides on intracellular Ca2+ in human eosinophils: activation of purinergic P2Y receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11346962&form=6&db=m Heterotrimeric G-protein and signal transduction in the nematode-trapping fungus Arthrobotrys dactyloides. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11348721&form=6&db=m Storage at -3 degrees C for 24 h alters the immunogenicity of pertussis vaccines. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11349070&form=6&db=m Ascaris suum-derived products induce human neutrophil activation via a G protein-coupled receptor that interacts with the interleukin-8 receptor pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11349970&form=6&db=m The seroepidemiology of B. pertussis infection in Catalonia, Spain. diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11350788&form=6&db=m IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11350863&form=6&db=m Differential prevention of morphine amnesia by antisense oligodeoxynucleotides directed against various Gi-protein alpha subunits. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11351031&form=6&db=m Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11352506&form=6&db=m Rac-1-mediated O2- secretion requires Ca2+ influx in neutrophil-like HL-60 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11353029&form=6&db=m A pertussis toxin-sensitive 8-lipoxygenase pathway is activated by a nicotinic acetylcholine receptor in aplysia neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11353812&form=6&db=m Prostaglandin F(2alpha) receptor-dependent regulation of prostaglandin transport. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11355882&form=6&db=m Pertussis toxin activates tyrosine kinase signaling cascade in myelomonocytic cells: a mechanism for cell adhesion. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11356044&form=6&db=m Sulfhydryl G proteins and phospholipase A(2)-associated G proteins are involved in adrenergic signal transduction in the rat pineal gland. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11356684&form=6&db=m Antiproliferative signaling of luteinizing hormone-releasing hormone in human endometrial and ovarian cancer cells through G protein alpha(I)-mediated activation of phosphotyrosine phosphatase. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11356857&form=6&db=m Time-dependent reversal of long-term potentiation by low-frequency stimulation at the hippocampal mossy fiber-CA3 synapses. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11356941&form=6&db=m Acetylcholine-induced desensitization of the contractile response to histamine in Guinea pig ileum is prevented by either pertussis toxin treatment or by selective inactivation of muscarinic M(3) receptors. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11359654&form=6&db=m Interleukin-6 production by endothelial cells via stimulation of protease-activated receptors is amplified by endotoxin and tumor necrosis factor-alpha. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11359779&form=6&db=m Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11360179&form=6&db=m The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11360187&form=6&db=m Urokinase/urokinase receptor and vitronectin/alpha(v)beta(3) integrin induce chemotaxis and cytoskeleton reorganization through different signaling pathways. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11369000&form=6&db=m Involvement of MAP kinases in the control of cPLA(2) and arachidonic acid release in endothelial cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11369634&form=6&db=m Chemotaxis and transendothelial migration of CD34(+) hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11369647&form=6&db=m Activation of the formyl peptide receptor by the HIV-derived peptide T-20 suppresses interleukin-12 p70 production by human monocytes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11369763&form=6&db=m Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Galpha(i). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11370673&form=6&db=m Inhibition of adenylyl cyclase activity in brain membrane fractions by arachidonic acid and related unsaturated fatty acids. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11374064&form=6&db=m Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic alpha-cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11374069&form=6&db=m Synergistic effects of ATP on oxytocin-induced intracellular Ca2+ response in mouse mammary myoepithelial cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11377418&form=6&db=m Adrenergic agonists induce heterologous sensitization of adenylate cyclase in NS20Y-D(2L) cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11385625&form=6&db=m Two-step activation of T cells, clonal expansion and subsequent Th1 cytokine production, is essential for the development of clinical autoimmune encephalomyelitis. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11389173&form=6&db=m Stromal cell-derived factor-1alpha induces astrocyte proliferation through the activation of extracellular signal-regulated kinases 1/2 pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11389876&form=6&db=m Beta gamma-mediated enhancement of corticotropin-releasing hormone-stimulated adenylyl cyclase activity by activation of gamma-aminobutyric acid(B) receptors in membranes of rat frontal cortex. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11389977&form=6&db=m Thromboxane A(2) receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11390975&form=6&db=m Heteromeric association creates a P2Y-like adenosine receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11392628&form=6&db=m Muscarinic receptors and gastrointestinal tract smooth muscle function. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11397545&form=6&db=m Differential roles of spinal cholera toxin- and pertussis toxin-sensitive G proteins in nociceptive responses caused by formalin, capsaicin, and substance P in mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11398076&form=6&db=m Human eosinophils induce histamine release from antigen-activated rat peritoneal mast cells: a possible role for mast cells in late-phase allergic reactions. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11399906&form=6&db=m GABA(B) receptors in anterior pituitary cells. Mechanism of action coupled to endocrine effects. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11401830&form=6&db=m Regulation of I(Cl,swell) in neuroblastoma cells by G protein signaling pathways. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11401957&form=6&db=m Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1beta in a new murine model for analysis of neuronal side effects of vaccination. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11404457&form=6&db=m Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11408277&form=6&db=m Pre- and postsynaptic inhibition by nociceptin in guinea pig small intestinal myenteric plexus in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11408399&form=6&db=m Effect of insulin and angiotensin II on cell calcium in human skin fibroblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11408541&form=6&db=m Enhanced cardiac L-type calcium current response to beta2-adrenergic stimulation in heart failure. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11408548&form=6&db=m Agonist Activity of the delta-antagonists TIPP and TIPP-psi in cellular models expressing endogenous or transfected delta-opioid receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11408601&form=6&db=m Nerve growth factor stimulation of p42/p44 mitogen-activated protein kinase in PC12 cells: role of G(i/o), G protein-coupled receptor kinase 2, beta-arrestin I, and endocytic processing. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11412835&form=6&db=m Regulation of p42/p44 mitogen-activated protein kinase by the human adenosine A3 receptor in transfected CHO cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11413231&form=6&db=m Selective inhibition of beta(2)-adrenergic receptor-mediated cAMP generation by activation of the P2Y(2) receptor in mouse pineal gland tumor cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11415936&form=6&db=m Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11415993&form=6&db=m C-terminal parathyroid hormone-related protein (PTHrP) (107-139) stimulates intracellular Ca(2+) through a receptor different from the type 1 PTH/PTHrP receptor in osteoblastic osteosarcoma UMR 106 cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11417850&form=6&db=m Disodium cromoglycate inhibits production of immunoglobulin E. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11418656&form=6&db=m Pertussis toxin inhibits induction of tissue-specific autoimmune disease by disrupting G protein-coupled signals. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11422447&form=6&db=m Antiproliferative properties of sphingosine-1-phosphate in human hepatic myofibroblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11425646&form=6&db=m Stimulation of sodium-dependent inorganic phosphate transport by activation of Gi/o-protein-coupled receptors by epinephrine in MC3T3-E1 osteoblast-like cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11426848&form=6&db=m Pertussis toxin-sensitive and -insensitive mechanisms of alpha1-adrenoceptor-mediated inotropic responses in rat heart. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11427538&form=6&db=m Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11427821&form=6&db=m [Cellular and acellular anti-pertussis vaccines] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11428170&form=6&db=m Age-related alterations in the signal transduction pathways of the elastin-laminin receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11428867&form=6&db=m Macrophage depletion prevents leukocyte adhesion and disease induction in experimental melanin-protein induced uveitis. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11429123&form=6&db=m Stimulation of HIV gp120-specific cytolytic T lymphocyte responses in vitro and in vivo using a detoxified pertussis toxin vector. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11432449&form=6&db=m Melatonin inhibits fatty acid transport in inguinal fat pads of hepatoma 7288CTC-bearing and normal Buffalo rats via receptor-mediated signal transduction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11437987&form=6&db=m Galanin suppresses calcium conductance and activates inwardly rectifying potassium channels in myenteric neurones from guinea-pig small intestine. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11438939&form=6&db=m Neuroprotective signal transduction in model motor neurons exposed to thrombin: G-protein modulation effects on neurite outgrowth, Ca(2+) mobilization, and apoptosis. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11445187&form=6&db=m Electrophysiological evidence for postsynaptic 5-HT(1A) receptor control of dorsal raphe 5-HT neurones. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11445281&form=6&db=m Pertussis toxin-induced hyperacute autoimmune encephalomyelitis in Lewis rats is correlated with increased expression of inducible nitric oxide synthase and tumor necrosis factor alpha. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11447772&form=6&db=m Experimental studies on the mechanism of phospholipase C activation by the lipid peroxidation products 4-hydroxynonenal and 2-nonenal. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11448477&form=6&db=m Biphasic response to human galanin of extracellular acidification in human Bowes melanoma cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11448967&form=6&db=m Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor signals through multiple pathways in endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11449818&form=6&db=m FMS*Calciumfluor increases alkaline phosphatase expression during osteogenesis in vitro of tibia-derived rat osteoblasts by activation of G alpha 0/G alpha i proteins. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11454581&form=6&db=m Characterization of effects of endothelin-1 on the L-type Ca2+ current in human atrial myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11454934&form=6&db=m Metabotropic neurosteroid/sigma-receptor involved in stimulation of nociceptor endings of mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11454957&form=6&db=m Regulation of a G protein-gated inwardly rectifying K+ channel by a Ca(2+)-independent protein kinase C. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11455198&form=6&db=m The association of heterotrimeric GTP-binding protein (Go) with microtubules. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11455205&form=6&db=m Monocyte chemotactic protein 1 amplifies serotonin-induced vascular smooth muscle cell proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11457590&form=6&db=m Distinct muscarinic receptors enhance spontaneous GABA release and inhibit electrically evoked GABAergic synaptic transmission in the chick lateral spiriform nucleus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11457861&form=6&db=m Galpha i2 enhances in vivo activation of and insulin signaling to GLUT4. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11457880&form=6&db=m Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridoma. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11458498&form=6&db=m Chemokine regulation of hematopoiesis and the involvement of pertussis toxin-sensitive G alpha i proteins. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11459804&form=6&db=m Calcitonin induces IL-6 production via both PKA and PKC pathways in the pituitary folliculo-stellate cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11460267&form=6&db=m Activation of mitogen-activated protein kinase by muscarinic receptors in astroglial cells: role in DNA synthesis and effect of ethanol. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11462769&form=6&db=m Post-stroke dementia. Nootropic drug modulation of neuronal nicotinic acetylcholine receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11465548&form=6&db=m Local anesthetic effects on priming and activation of human neutrophils. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11466206&form=6&db=m Oxytocin and lysophosphatidic acid induce stress fiber formation in human myometrial cells via a pathway involving Rho-kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11467306&form=6&db=m Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11470255&form=6&db=m Agonist properties of pindolol at h5-HT1A receptors coupled to mitogen-activated protein kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11471546&form=6&db=m Functional characterization of three mutations of the endothelin B receptor gene in patients with Hirschsprung's disease: evidence for selective loss of Gi coupling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11472251&form=6&db=m Cytokine and chemokine based control of HIV infection and replication. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11472294&form=6&db=m High concentrations of adrenergic antagonists prolong sciatic nerve blockade by tetrodotoxin. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11472785&form=6&db=m Signal transduction pathways activated by engaging immunoglobulin Fc receptors on chicken heterophils. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11473359&form=6&db=m Functional characterization of P2Y and P2X receptors in human eosinophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11476154&form=6&db=m Activation of human neutrophils by chlordane: induction of superoxide production and phagocytosis but not chemotaxis or apoptosis. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11479258&form=6&db=m Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11481272&form=6&db=m Nitric oxide attenuates alpha(2)-adrenergic receptors by ADP-ribosylation of G(i)alpha in ciliary epithelium. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11482521&form=6&db=m Differential response of mast cells separated from various organs and basophils of dogs to the fluoroquinolone antimicrobial levofloxacin. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11483264&form=6&db=m Immunogenicity and reactogenicity of diphtheria, tetanus and pertussis toxoids combined with inactivated polio vaccine, when administered concomitantly with or as a diluent for a Hib conjugate vaccine. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11483409&form=6&db=m Mechanisms of bradykinin-mediated Ca(2+) signalling in canine cultured corneal epithelial cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11485646&form=6&db=m Adaptation of Bordetella pertussis to vaccination: a cause for its reemergence? ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11488440&form=6&db=m Effects of beta-casomorphins on neuronal survival in culture of embryonic chick dorsal root ganglion neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11488814&form=6&db=m Binding of the non-typeable Haemophilus influenzae lipooligosaccharide to the PAF receptor initiates host cell signalling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11489454&form=6&db=m 5-HT1A receptor-mediated activation of G-protein-gated inwardly rectifying K+ current in rat periaqueductal gray neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11493464&form=6&db=m Autocrine antiapoptotic stimulation of cultured adult T-cell leukemia cells by overexpression of the chemokine I-309. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11493520&form=6&db=m SDF-1 alpha induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11494060&form=6&db=m Role of the third intracellular loop and of the cytoplasmic tail in the mitogenic signaling of the protease-activated receptor 1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11494406&form=6&db=m Modulation of voltage-dependent calcium currents by serotonin in acutely isolated rat amygdala neurons. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11495629&form=6&db=m Evidence for the involvement of Gi2 in activation of extracellular signal-regulated kinases in hepatocytes. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11495921&form=6&db=m Overexpression of beta 1 and beta 2 adrenergic receptors in rat atrial myocytes. Differential coupling to G protein-gated inward rectifier K(+) channels via G(s) and G(i)/o. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11495948&form=6&db=m Impaired inhibitory G-protein function contributes to increased calcium currents in rats with diabetic neuropathy. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11498525&form=6&db=m Activation of the p38 and p42/p44 mitogen-activated protein kinase families by the histamine H(1) receptor in DDT(1)MF-2 cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11498966&form=6&db=m [Effect of ET-1 on intracellular free calcium in cultured neonatal myocardial cells] causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11500425&form=6&db=m Genotypic variation in the Bordetella pertussis virulence factors pertactin and pertussis toxin in historical and recent clinical isolates in the United Kingdom. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11500506&form=6&db=m Galpha(i2) enhances insulin signaling via suppression of protein-tyrosine phosphatase 1B. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11502890&form=6&db=m Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11504788&form=6&db=m Biphasic alterations of cAMP levels and inhibition of norepinephrine release in iris-ciliary body by bremazocine. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11504798&form=6&db=m Agonist-, antagonist-, and inverse agonist-regulated trafficking of the delta-opioid receptor correlates with, but does not require, G protein activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11505216&form=6&db=m Haemodynamic characterization of young normotensive men carrying the 825T-allele of the G-protein beta3 subunit. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11507066&form=6&db=m Growth-inhibitory effect of a streptococcal antitumor glycoprotein on human epidermoid carcinoma A431 cells: involvement of dephosphorylation of epidermal growth factor receptor. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11507164&form=6&db=m Interaction between the RGS domain of RGS4 with G protein alpha subunits mediates the voltage-dependent relaxation of the G protein-gated potassium channel. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11507208&form=6&db=m Mechanisms involved in stimulation of human immunodeficiency virus type 1 replication by aminooxypentane RANTES. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11509538&form=6&db=m Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11513354&form=6&db=m Sensitization of adenylate cyclase induced by a dopamine D2 receptor mutant: inverse agonism by D2 receptor antagonists. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11516624&form=6&db=m Endothelin-1 increases glucose transporter glut1 mRNA accumulation in 3T3-L1 adipocytes by a mitogen-activated protein kinase-dependent pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11516842&form=6&db=m Bradykinin activates airway parasympathetic ganglion neurons by inhibiting M-currents. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11517154&form=6&db=m Inhibition of isoproterenol-induced lipolysis in rat inguinal adipocytes in vitro by physiological melatonin via a receptor-mediated mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11518777&form=6&db=m Dopamine D(2) receptor activation causes mitogenesis via p44/42 mitogen-activated protein kinase in opossum kidney cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11518778&form=6&db=m Expression of connective tissue growth factor in human renal fibroblasts: regulatory roles of RhoA and cAMP. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11518803&form=6&db=m Activation of MAPK by TRH requires clathrin-dependent endocytosis and PKC but not receptor interaction with beta-arrestin or receptor endocytosis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11520252&form=6&db=m Antibody responses of healthy infants to concurrent administration of a bivalent haemophilus influenzae type b-hepatitis B vaccine with diphtheria-tetanus-pertussis, polio and measles-mumps-rubella vaccines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11520794&form=6&db=m Antineutrophil cytoplasm autoantibodies from patients with systemic vasculitis activate neutrophils through distinct signaling cascades: comparison with conventional Fcgamma receptor ligation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11522591&form=6&db=m Assessment of agonism at G-protein coupled receptors by phosphatidic acid and lysophosphatidic acid in human embryonic kidney 293 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11522605&form=6&db=m Pharmacological characterization of adenosine receptors in PGT-beta mouse pineal gland tumour cells. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11527212&form=6&db=m Contact-activated migration of melanoma B16 and sarcoma XC cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11527383&form=6&db=m Type A allatostatins from Drosophila melanogaster and Diplotera puncata activate two Drosophila allatostatin receptors, DAR-1 and DAR-2, expressed in CHO cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11527419&form=6&db=m R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11532906&form=6&db=m Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11532968&form=6&db=m A novel cardioprotective role of RhoA: new signaling mechanism for adenosine. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11532976&form=6&db=m Expression and function of adenosine receptors in human dendritic cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11533055&form=6&db=m Chemoattractant-stimulated NF-kappaB activation is dependent on the low molecular weight GTPase RhoA. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11533056&form=6&db=m Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11533127&form=6&db=m Differential regulation of G protein-gated inwardly rectifying K(+) channel kinetics by distinct domains of RGS8. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11533141&form=6&db=m Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11535060&form=6&db=m Fluorescence correlation spectroscopy detects galanin receptor diversity on insulinoma cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11535291&form=6&db=m Neurosteroids stimulate G protein-coupled sigma receptors in mouse brain synaptic membrane. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11543952&form=6&db=m Modulation of ethanol-induced motor incoordination by mouse striatal A(1) adenosinergic receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11544795&form=6&db=m [Calcium-independent inhibition of the spontaneous release of GABA by baclofen in the rat hippocampus] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11546556&form=6&db=m The effect of 24R,25-(OH)(2)D(3) on protein kinase C activity in chondrocytes is mediated by phospholipase D whereas the effect of 1alpha,25-(OH)(2)D(3) is mediated by phospholipase C. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11546652&form=6&db=m Essential role for extracellular Ca(2+) in JNK activation by mechanical stretch in bladder smooth muscle cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11546658&form=6&db=m Gap junction assembly: PTX-sensitive G proteins regulate the distribution of connexin43 within cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11549699&form=6&db=m Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. diagnostic usage,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11550977&form=6&db=m Granulocyte-macrophage colony stimulating factor activates proteoglycan, type II collagen, and cAMP production by rat articular chondrocytes through specific binding sites. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11553279&form=6&db=m Multiple pertussis toxin-sensitive G-proteins can couple receptors to GIRK channels in rat sympathetic neurons when expressed heterologously, but only native G(i)-proteins do so in situ. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11553541&form=6&db=m Role of ADP-ribosyltransferase activity of pertussis toxin in toxin-adhesin redundancy with filamentous hemagglutinin during Bordetella pertussis infection. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11553570&form=6&db=m Mimicry of a G protein mutation by pertussis toxin expression in transgenic Caenorhabditis elegans. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11557588&form=6&db=m Regulation of eosinophil function by phosphatidylinositol-specific PLC and cytosolic PLA(2). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11557621&form=6&db=m Hypocretin/orexin suppresses corticotroph responsiveness in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11557736&form=6&db=m Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11560360&form=6&db=m Agonist-independent modulation of L-type Ca currents by basal Gs protein activities in single guinea pig ventricular myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11562445&form=6&db=m Short-term inverse-agonist treatment induces reciprocal changes in delta-opioid agonist and inverse-agonist binding capacity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11566448&form=6&db=m 5-Aminosalicylate stimulates phospholipase D activity in macrophages. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11566737&form=6&db=m Cellular mechanisms by which oxytocin mediates ovine endometrial prostaglandin F2alpha synthesis: role of G(i) proteins and mitogen-activated protein kinases. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11566904&form=6&db=m Enhanced interaction between renovascular alpha(2)-adrenoceptors and angiotensin II receptors in genetic hypertension. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11566906&form=6&db=m Angiotensin II type 2 receptor inhibits epidermal growth factor receptor transactivation by increasing association of SHP-1 tyrosine phosphatase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11567778&form=6&db=m Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11567789&form=6&db=m Cellular expression of functional chemokine receptor CCR5 and CXCR4 in human embryonic neurons. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11579141&form=6&db=m Agonists of the P2Y(AC)-receptor activate MAP kinase by a ras-independent pathway in rat C6 glioma. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11579142&form=6&db=m Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11579162&form=6&db=m Catecholamines are not linked to myometrial phospholipase C and uterine contraction in late pregnant and parturient mouse. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11580213&form=6&db=m A quantitative analysis for the ADP-ribosylation activity of pertussis toxin: an enzymatic-HPLC coupled assay applicable to formulated whole cell and acellular pertussis vaccine products. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11580279&form=6&db=m Constitutive activation of the mu opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11583817&form=6&db=m Characteristics and distribution of endogenous RFamide-related peptide-1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11583920&form=6&db=m Factors affecting prostacyclin receptor agonist efficacy in different cell types. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11585627&form=6&db=m Defective CD4T cell priming and resistance to experimental autoimmune encephalomyelitis in TNF-deficient mice due to innate immune hypo-responsiveness. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11589511&form=6&db=m Salt intake and intestinal dopaminergic activity in adult and old Fischer 344 rats. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11590141&form=6&db=m Constitutive activation of NF-kappa B and secretion of interleukin-8 induced by the G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus involve G alpha(13) and RhoA. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11590201&form=6&db=m Selective attraction of naive and memory B cells by dendritic cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11591716&form=6&db=m Poxvirus infection rapidly activates tyrosine kinase signal transduction. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11595507&form=6&db=m Characterization of PGE(2) receptors (EP) and their role as mediators of 1alpha,25-(OH)(2)D(3) effects on growth zone chondrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11597896&form=6&db=m ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11598055&form=6&db=m Bordetella pertussis autoregulates pertussis toxin production through the metabolism of cysteine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11598073&form=6&db=m Reciprocal protective immunity against Bordetella pertussis and Bordetella parapertussis in a murine model of respiratory infection. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11600412&form=6&db=m Endothelin-1 decreases glutamate uptake in primary cultured rat astrocytes. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11602660&form=6&db=m Modulation of N-type Ca2+ currents by A1-adenosine receptor activation in male rat pelvic ganglion neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605942&form=6&db=m Activation of mu-opioid receptor induces expression of c-fos and junB via mitogen-activated protein kinase cascade. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11607369&form=6&db=m Guanine nucleotide binding protein involvement in early steps of phytochrome-regulated gene expression. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11641261&form=6&db=m Additive activation of hepatic NF-kappaB by ethanol and hepatitis B protein X (HBX) or HCV core protein: involvement of TNF-alpha receptor 1-independent and -dependent mechanisms. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11641437&form=6&db=m Anti-inflammatory effects of the partially purified extract of radix Stephaniae tetrandrae: comparative studies of its active principles tetrandrine and fangchinoline on human polymorphonuclear leukocyte functions. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11642633&form=6&db=m Safety and immunogenicity of Biken acellular pertussis vaccine in combination with diphtheria and tetanus toxoid as a fifth dose at four to six years of age. Munich Vaccine Study Group. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11668060&form=6&db=m Platelet-conditioned medium increases endothelial electrical resistance independently of cAMP/PKA and cGMP/PKG. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11672891&form=6&db=m Temporal nucleotide changes in pertactin and pertussis toxin genes in Bordetella pertussis strains isolated from clinical cases in Poland. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11673480&form=6&db=m Cutting edge: CCR4 mediates antigen-primed T cell binding to activated dendritic cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11673556&form=6&db=m Chemokines regulate IL-6 and IL-8 production by fibroblast-like synoviocytes from patients with rheumatoid arthritis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11673569&form=6&db=m Induction of type 1 immune pathology in the brain following immunization without central nervous system autoantigen in transgenic mice with astrocyte-targeted expression of IL-12. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11675042&form=6&db=m Mechanisms underlying attenuated contractile response of aortic rings to noradrenaline in fructose-fed mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11677265&form=6&db=m Cannabinoid receptor agonists inhibit depolarization-induced calcium influx in cerebellar granule neurons. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11679162&form=6&db=m Development of a homogeneous MAP kinase reporter gene screen for the identification of agonists and antagonists at the CXCR1 chemokine receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11682611&form=6&db=m Intracellular retention of the two isoforms of the D(2) dopamine receptor promotes endoplasmic reticulum disruption. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11682614&form=6&db=m Noradrenaline and alpha-adrenergic signaling induce the hsp70 gene promoter in mollusc immune cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11687510&form=6&db=m Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11689171&form=6&db=m Melatonin-induced suppression of PC12 cell growth is mediated by its Gi coupled transmembrane receptors. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11689354&form=6&db=m Mechanisms of Bordetella pathogenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11689635&form=6&db=m Unique monoclonal antibody recognizing the third extracellular loop of CXCR4 induces lymphocyte agglutination and enhances human immunodeficiency virus type 1-mediated syncytium formation and productive infection. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11691864&form=6&db=m ACh-induced rebound stimulation of L-type Ca(2+) current in guinea-pig ventricular myocytes, mediated by Gbetagamma-dependent activation of adenylyl cyclase. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11692173&form=6&db=m Molecular basis for the insulinomimetic effects of C-peptide. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11694002&form=6&db=m Chemotactic responses of osteoblastic MC3T3-E1 cells toward zinc chloride. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11694445&form=6&db=m Differential regulation of airway mucin gene expression and mucin secretion by extracellular nucleotide triphosphates. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11694665&form=6&db=m Sustained efficacy during the first 6 years of life of 3-component acellular pertussis vaccines administered in infancy: the Italian experience. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11695897&form=6&db=m Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11695993&form=6&db=m Cannabinoid-receptor-independent cell signalling by N-acylethanolamines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11696454&form=6&db=m Gp120-induced Bob/GPR15 activation: a possible cause of human immunodeficiency virus enteropathy. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11696575&form=6&db=m The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11697799&form=6&db=m A role for G protein-coupled lysophospholipid receptors in sphingolipid-induced Ca2+ signaling in MC3T3-E1 osteoblastic cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11697895&form=6&db=m Involvement of heterotrimeric G proteins in phagocytosis and recycling from the phagosomal compartment. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11698270&form=6&db=m HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11705398&form=6&db=m Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11705943&form=6&db=m Pertussis toxin and lipopolysaccharide influence phagocytosis of Bordetella pertussis by human monocytes. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11709761&form=6&db=m How to make sense of pertussis immunogenicity data. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11711493&form=6&db=m Gangliosides GM1 and GM2 induce vascular smooth muscle cell proliferation via extracellular signal-regulated kinase 1/2 pathway. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11711579&form=6&db=m Rapid and non-genomic reduction of intracellular [Ca(2+)] induced by aldosterone in human bronchial epithelium. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11714883&form=6&db=m M2 muscarinic autoreceptors modulate acetylcholine release in prefrontal cortex of C57BL/6J mouse. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11714903&form=6&db=m Acetylcholine-induced desensitization of muscarinic contractile response in Guinea pig ileum is inhibited by pertussis toxin treatment. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11716854&form=6&db=m Hyper-osmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11717135&form=6&db=m Somatostatin inhibits stem cell factor messenger RNA expression by Sertoli cells and stem cell factor-induced DNA synthesis in isolated seminiferous tubules. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11717137&form=6&db=m Resumption of meiosis induced by meiosis-activating sterol has a different signal transduction pathway than spontaneous resumption of meiosis in denuded mouse oocytes cultured in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11720885&form=6&db=m Protein kinase C-independent stimulation of activator protein-1 and c-Jun N-terminal kinase activity in human endometrial cancer cells by the LHRH agonist triptorelin. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11723828&form=6&db=m [The elastin-laminin receptor] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11724851&form=6&db=m Polymorphism of Bordetella pertussis isolates circulating for the last 10 years in France, where a single effective whole-cell vaccine has been used for more than 30 years. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11725002&form=6&db=m Further Elucidation of a Pertussis Toxin-Sensitive Transmembrane Signaling Mechanism Involved in Central alpha(2)-Adrenoceptor Activation in the Rat. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11725034&form=6&db=m Neutrophil Priming Mechanisms of Sulfolipid-I and N-Formyl-Methionyl-Leucyl-Phenylalanine. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11725063&form=6&db=m Subtypes of Guanine-Nucleotide-Binding Regulatory Proteins at the Locus coeruleus Involved in Fentanyl-Induced Muscular Rigidity in the Rat. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11725084&form=6&db=m Characterization of Phospholipase A(2) Activation by Plasmin in Cultured Bovine Endothelial Cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11726396&form=6&db=m LPS induces eosinophil migration via CCR3 signaling through a mechanism independent of RANTES and Eotaxin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11726672&form=6&db=m Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins, beta gamma subunits, small GTPase CDC42, and partly by Rac-1. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11726708&form=6&db=m Relationship between the self-incompatibility and cAMP level in Lilium longiflorum. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11728164&form=6&db=m Sphingosine-1-phosphate effects on PKC isoform expression in human osteoblastic cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11728477&form=6&db=m Production of beta-defensin-2 by human colonic epithelial cells induced by Salmonella enteritidis flagella filament structural protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11729229&form=6&db=m Regulation of vascular proteoglycan synthesis by angiotensin II type 1 and type 2 receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11730806&form=6&db=m Serotonin potentiates angiotensin II--induced vascular smooth muscle cell proliferation. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11731576&form=6&db=m A novel function of sphingosine-1-phosphate to activate a non-selective cation channel in human endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11731642&form=6&db=m Immunologic and epidemiologic experience of vaccination with a monocomponent pertussis toxoid vaccine. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11732925&form=6&db=m Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11739530&form=6&db=m CXCR3 internalization following T cell-endothelial cell contact: preferential role of IFN-inducible T cell alpha chemoattractant (CXCL11). therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11740950&form=6&db=m Noradrenaline stimulates 5-hydroxytryptamine release from mouse ileal tissues via alpha(2)-adrenoceptors. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11741903&form=6&db=m Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11742202&form=6&db=m Manganese stimulates stellation of cultured rat cortical astrocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11743973&form=6&db=m Acidic stimuli activates two distinct pathways in taste receptor cells from rat fungiform papillae. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11744250&form=6&db=m Melatonin generates an outward potassium current in rat suprachiasmatic nucleus neurones in vitro independent of their circadian rhythm. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11744747&form=6&db=m Functional expression and FRET analysis of green fluorescent proteins fused to G-protein subunits in rat sympathetic neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745701&form=6&db=m NG2/HMPG modulation of human articular chondrocyte adhesion to type VI collagen is lost in osteoarthritis. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11746436&form=6&db=m Biologically active sequence (KDI) mediates the neurite outgrowth function of the gamma-1 chain of laminin-1. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11746835&form=6&db=m Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11747364&form=6&db=m Intracellular signaling pathway of FGF-2-modulated corneal endothelial cell migration during wound healing in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11747992&form=6&db=m Phospholipase D stimulation is required for sphingosine-1-phosphate activation of actin stress fibre assembly in human airway epithelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11748272&form=6&db=m Shear-dependent eosinophil transmigration on interleukin 4-stimulated endothelial cells: a role for endothelium-associated eotaxin-3. causal interaction,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11750103&form=6&db=m The chemokine receptor CXCR4 enhances integrin-mediated in vitro adhesion and facilitates engraftment of leukemic precursor-B cells in the bone marrow. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751269&form=6&db=m A role for the human sperm glycine receptor/Cl(-) channel in the acrosome reaction initiated by recombinant ZP3. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751586&form=6&db=m Regulation of the PRL promoter by Akt through cAMP response element binding protein. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751850&form=6&db=m GIPC participates in G protein signaling downstream of insulin-like growth factor 1 receptor. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751915&form=6&db=m Characterization of endocrine gland-derived vascular endothelial growth factor signaling in adrenal cortex capillary endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11752134&form=6&db=m Extracellular signal-regulated kinases and g protein-coupled receptors in megakaryocytic human erythroleukemia cells: selective activation, differential regulation, and dissociation from mitogenesis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11752209&form=6&db=m Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11755131&form=6&db=m Up-regulation of RGS4 mRNA by opioid receptor agonists in PC12 cells expressing cloned mu- or kappa-opioid receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11758972&form=6&db=m Regulation of gadd153 mRNA expression by hypoxia in pulmonary artery smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11773099&form=6&db=m Multiplex LightCycler PCR assay for detection and differentiation of Bordetella pertussis and Bordetella parapertussis in nasopharyngeal specimens. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11773239&form=6&db=m Beta 2-adrenergic receptor signaling acts via NO release to mediate ACh-induced activation of ATP-sensitive K+ current in cat atrial myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11773407&form=6&db=m The rat cytomegalovirus R33-encoded G protein-coupled receptor signals in a constitutive fashion. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11779148&form=6&db=m Augmentation of receptor-mediated adenylyl cyclase activity by Gi-coupled prostaglandin receptor subtype EP3 in a Gbetagamma subunit-independent manner. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11779205&form=6&db=m Apelin (65-77) activates extracellular signal-regulated kinases via a PTX-sensitive G protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11782516&form=6&db=m Clostridium perfringens alpha-toxin induces rabbit neutrophil adhesion. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11784854&form=6&db=m Stromal cell-derived factor 1alpha activates LIM kinase 1 and induces cofilin phosphorylation for T-cell chemotaxis. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11786377&form=6&db=m Arachidonic acid release from rat Leydig cells: the involvement of G protein, phospholipase A2 and regulation of cAMP production. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11786381&form=6&db=m Differential effects of genistein on apoptosis induced by fluoride and pertussis toxin in human and rat pancreatic islets and RINm5F cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11789669&form=6&db=m Involvement of mitogen-activated protein kinases in the signal transduction pathway of bone marrow-derived macrophage activation in response to in vitro treatment with thymosin alpha 1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11789896&form=6&db=m Thromboxane receptor signalling in human myometrial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11792571&form=6&db=m Fluoroaluminate stimulates phosphorylation of p130 Cas and Fak and increases attachment and spreading of preosteoblastic MC3T3-E1 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11794322&form=6&db=m High IFN-alpha expression is associated with the induction of experimental autoimmune uveitis (EAU) in Fischer 344 rat. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11795489&form=6&db=m The synthetic peptide, His-Phe-Tyr-Leu-Pro-Met, is a chemoattractant for Jukat T cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11798872&form=6&db=m [Mechanism of the activation of extracellular signal-regulated kinase (ERK) in prostate cancer cell lines with different metastatic potential] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11803554&form=6&db=m mt(1) Receptor-mediated antiproliferative effects of melatonin on the rat uterine antimesometrial stromal cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11805429&form=6&db=m Mechanism of bradykinin-induced Ca(2+) mobilization in MG63 human osteosarcoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11812653&form=6&db=m Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11812655&form=6&db=m Thrombin-stimulated cell proliferation mediated through activation of Ras/Raf/MEK/MAPK pathway in canine cultured tracheal smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11812774&form=6&db=m Heterotrimeric G-proteins activate Cl- channels through stimulation of a cyclooxygenase-dependent pathway in a model liver cell line. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11815366&form=6&db=m Functional characterization of an endogenous Xenopus oocyte adenosine receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11818163&form=6&db=m Efficacy of pertussis components in an acellular vaccine, as assessed in a murine model of respiratory infection and a murine intracerebral challenge model. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11818447&form=6&db=m fMLP-induced in vitro nitric oxide production and its regulation in murine peritoneal macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11821388&form=6&db=m Apoptotic effect of sphingosine 1-phosphate and increased sphingosine 1-phosphate hydrolysis on mesangial cells cultured at low cell density. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11821398&form=6&db=m Extracellular mRNA induces dendritic cell activation by stimulating tumor necrosis factor-alpha secretion and signaling through a nucleotide receptor. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11823530&form=6&db=m Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11824374&form=6&db=m Mg(++)-induced endothelial cell migration: substratum selectivity and receptor-involvement. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11825003&form=6&db=m Characteristics and potency of an acellular pertussis vaccine composed of pertussis toxin, filamentous hemagglutinin, and pertactin. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11825890&form=6&db=m The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP: evidence for a strong reduction of Ca2+ entry in single nerve terminals. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11827704&form=6&db=m OxLDL upregulates CXCR2 expression in monocytes via scavenger receptors and activation of p38 mitogen-activated protein kinase. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11831860&form=6&db=m Effects of isoflurane on voltage-dependent calcium fluxes in rabbit T-tubule membranes: comparison with alcohols. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11832434&form=6&db=m PTH and DA regulate Na-K ATPase through divergent pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11834242&form=6&db=m Involvement of Rho and tyrosine kinase in angiotensin II-induced actin reorganization in mesothelial cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11834615&form=6&db=m Inhibition of adenylyl cyclase by neuronal P2Y receptors. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11835758&form=6&db=m Mechanism of macrophage injury following traumatic hemorrhagic shock: through PTX-sensitive G-protein-mediated signal transduction pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11837635&form=6&db=m Stability of antibodies to Bordetella antigens in German adults. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11846406&form=6&db=m Cloning and functional expression of the first Drosophila melanogaster sulfakinin receptor DSK-R1. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11846867&form=6&db=m Do early childhood immunizations influence the development of atopy and do they cause allergic reactions? causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11852105&form=6&db=m Distinct regions of C-terminus of the high affinity neurotensin receptor mediate the functional coupling with pertussis toxin sensitive and insensitive G-proteins. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11853542&form=6&db=m Sphingosine 1-phosphate evokes calcium signals in C2C12 myoblasts via Edg3 and Edg5 receptors. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11853873&form=6&db=m Activation of extracellular signal regulated protein kinase by neuropeptide Y and pancreatic polypeptide in CHO cells expressing the NPY Y(1), Y(2), Y(4) and Y(5) receptor subtypes. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11854200&form=6&db=m Membrane localization of the S1 subunit of pertussis toxin in Bordetella pertussis and implications for pertussis toxin secretion. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11855746&form=6&db=m Differential effects of bacterial toxins on mitogenic actions of sodium fluoride and those of aluminum fluoride in human TE85 osteosarcoma cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11855845&form=6&db=m Lysophosphatidic acid stimulates p21-activated kinase in vascular smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11856353&form=6&db=m Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11857341&form=6&db=m The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a potent stimulant of mast cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11858794&form=6&db=m Ginseng and ginsenoside Rg3, a newly identified active ingredient of ginseng, modulate Ca2+ channel currents in rat sensory neurons. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11858797&form=6&db=m Pharmacological characterisation of the goldfish somatostatin sst5 receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11858944&form=6&db=m Signal transduction mechanism via adenosine A1 receptor in the cat esophageal smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11861323&form=6&db=m Stimulation of beta(3)-adrenoceptors causes phosphorylation of p38 mitogen-activated protein kinase via a stimulatory G protein-dependent pathway in 3T3-L1 adipocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11861492&form=6&db=m Evidence for a direct negative coupling between dopamine-D2 receptors and PLC by heterotrimeric Gi1/2 proteins in rat anterior pituitary cell membranes. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11861515&form=6&db=m Rapid nongenomic E2 effects on p42/p44 MAPK, activator protein-1, and cAMP response element binding protein in rat white adipocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11861776&form=6&db=m Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11866977&form=6&db=m [Activation of p38 and c-Jun NH2-terminal kinase mitogen-activated protein kinases in human prostate carcinoma cell lines with different metastatic potentials] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11867691&form=6&db=m Beta(3)-mediated engulfment of apoptotic tumor cells by dendritic cells is dependent on CAMKII: inhibition by HIV-1 Tat. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11870619&form=6&db=m Generation of adult-like antibody avidity profiles after early-life immunization with protein vaccines. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11870628&form=6&db=m Activation of pertussis toxin-sensitive CXCL12 (SDF-1) receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11873241&form=6&db=m Lysophosphatidic acid augments fibroblast-mediated contraction of released collagen gels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11876771&form=6&db=m Regulation of acetylcholine release by muscarinic receptors at the mouse neuromuscular junction depends on the activity of acetylcholinesterase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11877414&form=6&db=m Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11880151&form=6&db=m Regulation of calcium currents by chemokines and their receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11881494&form=6&db=m [Humoral response to the injection of acellular Pertussis vaccine] diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11882295&form=6&db=m Signal-dependent translocation of transducin, RGS9-1-Gbeta5L complex, and arrestin to detergent-resistant membrane rafts in photoreceptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11882385&form=6&db=m G protein specificity: traffic direction required. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11882652&form=6&db=m Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11882676&form=6&db=m Prostaglandin E(2) inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11884459&form=6&db=m Eotaxin/CCL11 suppresses IL-8/CXCL8 secretion from human dermal microvascular endothelial cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11889121&form=6&db=m Guanylin, uroguanylin, and heat-stable euterotoxin activate guanylate cyclase C and/or a pertussis toxin-sensitive G protein in human proximal tubule cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11891009&form=6&db=m N-terminal chromogranin-derived peptides as dilators of bovine coronary resistance arteries. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11891218&form=6&db=m alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11897114&form=6&db=m Gabapentin-mediated inhibition of voltage-activated Ca2+ channel currents in cultured sensory neurones is dependent on culture conditions and channel subunit expression. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11897851&form=6&db=m Multiple regulation by external ATP of nifedipine-insensitive, high voltage-activated Ca(2+) current in guinea-pig mesenteric terminal arteriole. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11900797&form=6&db=m Mu-opioid receptor down-regulation and tolerance are not equally dependent upon G-protein signaling. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11901233&form=6&db=m Functional expression of a novel ginsenoside Rf binding protein from rat brain mRNA in Xenopus laevis oocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11902114&form=6&db=m Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11905990&form=6&db=m Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: involvement of NO synthase via a novel pertussis toxin target. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11906757&form=6&db=m Distribution of pertussis antibodies among different age groups in Japan. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11907035&form=6&db=m Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11907074&form=6&db=m Interaction between Src homology 2 domain bearing protein tyrosine phosphatase substrate-1 and CD47 mediates the adhesion of human B lymphocytes to nonactivated endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11907831&form=6&db=m Opioid receptor-mediated effects of interleukin-2 on the [Ca2+]i transient and contraction in isolated ventricular myocytes of the rat. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11918819&form=6&db=m Bacterial secrets of secretion: EuroConference on the biology of type IV secretion processes. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11919159&form=6&db=m RhoA- and RhoD-dependent regulatory switch of Galpha subunit signaling by PAR-1 receptors in cellular invasion. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11919181&form=6&db=m Dose-dependent activation of antiapoptotic and proapoptotic pathways by ethanol treatment in human vascular endothelial cells: differential involvement of adenosine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11919704&form=6&db=m Modulation of the cardiac pacemaker of Drosophila: cellular mechanisms. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11923291&form=6&db=m Thrombospondin stimulates focal adhesion disassembly through Gi- and phosphoinositide 3-kinase-dependent ERK activation. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11929756&form=6&db=m Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11930219&form=6&db=m [Effect of interleukin-2 on intracellular calcium transients in rat ventricular myocytes] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11932463&form=6&db=m Interaction of human Tamm-Horsfall glycoprotein with Bordetella pertussis toxin. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11934646&form=6&db=m Calcium-sensing receptor-mediated activation of phospholipase C-gamma1 is downstream of phospholipase C-beta and protein kinase C in MC3T3-E1 osteoblasts. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11934705&form=6&db=m alpha(2B)-Adrenergic receptors activate MAPK and modulate proliferation of primary cultured proximal tubule cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11934810&form=6&db=m Neuropeptide Y increases 4-aminopyridine-sensitive transient outward potassium current in rat ventricular myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11934836&form=6&db=m Regulation of eNOS expression in brain endothelial cells by perinuclear EP(3) receptors. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11934878&form=6&db=m Epithelial cell-derived human beta-defensin-2 acts as a chemotaxin for mast cells through a pertussis toxin-sensitive and phospholipase C-dependent pathway. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11934880&form=6&db=m Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11936187&form=6&db=m Fibronectin promotes calcium signaling by interferon-gamma in human neutrophils via G-protein and sphingosine kinase-dependent mechanisms. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11939794&form=6&db=m Lysophosphatidic acid and receptor-mediated activation of endothelial nitric-oxide synthase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11940595&form=6&db=m Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. Implication of phosphatidynositol 3-kinases. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11943209&form=6&db=m Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11943650&form=6&db=m Cyclic stretch activates ERK1/2 via G proteins and EGFR in alveolar epithelial cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11943854&form=6&db=m Activation of mislocalized opsin kills rod cells: a novel mechanism for rod cell death in retinal disease. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11949887&form=6&db=m Enhanced cAMP response of naturally occurring mutant of human beta3-adrenergic receptor. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11953363&form=6&db=m DsbA and DsbC are required for secretion of pertussis toxin by Bordetella pertussis. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11953388&form=6&db=m Mycoplasma hyopneumoniae increases intracellular calcium release in porcine ciliated tracheal cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11955723&form=6&db=m Effect of pertussis toxin and N-ethylmaleimide on voltage-dependent and -independent calcium current modulation in serotonergic neurons. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11956150&form=6&db=m Neuropeptide Y inhibits spontaneous alpha-melanocyte-stimulating hormone (alpha-MSH) release via a Y(5) receptor and suppresses thyrotropin-releasing hormone-induced alpha-MSH secretion via a Y(1) receptor in frog melanotrope cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11956155&form=6&db=m Intracellular calcium mobilization in response to the activation of human wild-type and chimeric gonadotropin receptors. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11956157&form=6&db=m Activation of 5-HT(7) receptor in rat glomerulosa cells is associated with an increase in adenylyl cyclase activity and calcium influx through T-type calcium channels. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11956190&form=6&db=m Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11956320&form=6&db=m Leukotriene D(4) activates MAPK through a Ras-independent but PKCepsilon-dependent pathway in intestinal epithelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11958818&form=6&db=m Expression of functional chemokine receptors by rat cerebellar neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11959433&form=6&db=m Oral colonization and immune responses to Streptococcus gordonii expressing a pertussis toxin S1 fragment in mice. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11959661&form=6&db=m Enhanced IPC by activation of pertussis toxin-sensitive and -insensitive G protein-coupled purinoceptors. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11959787&form=6&db=m A direct inhibitory action of prostaglandins upon ACTH secretion at the late stages of the secretory pathway of AtT-20 cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11959800&form=6&db=m Stimulation of protein kinase B and p70 S6 kinase by the histamine H1 receptor in DDT1MF-2 smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11960616&form=6&db=m Rapid activation of endothelial NO synthase by estrogen: evidence for a steroid receptor fast-action complex (SRFC) in caveolae. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11961575&form=6&db=m [Evaluation of G(i/o) protein signal transduction pathway in cardioprotection of hypoxic preconditioning] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11970732&form=6&db=m Study of the functional organization of a novel adenylate cyclase signaling mechanism of insulin action. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11971026&form=6&db=m IL-16 promotes leukotriene C(4) and IL-4 release from human eosinophils via CD4- and autocrine CCR3-chemokine-mediated signaling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11972628&form=6&db=m A cathelicidin family of human antibacterial peptide LL-37 induces mast cell chemotaxis. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11973452&form=6&db=m Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11976935&form=6&db=m Mechanisms for the inhibition of amiloride-sensitive Na+ absorption by extracellular nucleotides in mouse trachea. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11978819&form=6&db=m Ca2+-independent feedback inhibition of acetylcholine release in frog neuromuscular junction. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11980903&form=6&db=m Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11982794&form=6&db=m 2[125I]Iodomelatonin binding and interaction with beta-adrenergic signaling in chick heart/coronary artery physiology. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11985519&form=6&db=m IFNgamma induces functional chemokine receptor expression in human mesangial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11988073&form=6&db=m Somatostatin-induced paradoxical increase in intracellular Ca2+ concentration and insulin release in the presence of arginine vasopressin in clonal HIT-T15 beta-cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11988217&form=6&db=m A voltage-independent K+ conductance activated by cell swelling in Ehrlich cells is modulated by a G-protein-mediated process. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11994484&form=6&db=m The chemokine stromal cell-derived factor-1 alpha modulates alpha 4 beta 7 integrin-mediated lymphocyte adhesion to mucosal addressin cell adhesion molecule-1 and fibronectin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11994504&form=6&db=m Different G(i)-coupled chemoattractant receptors signal qualitatively different functions in human neutrophils. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12002533&form=6&db=m Serological diagnosis of pertussis: evaluation of IgA against whole cell and specific Bordetella pertussis antigens as markers of recent infection. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12003791&form=6&db=m Human bronchial epithelial cells express PAR-2 with different sensitivity to thermolysin. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12003810&form=6&db=m Anandamide-induced vasorelaxation in rabbit aortic rings has two components: G protein dependent and independent. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12003925&form=6&db=m The PtlE protein of Bordetella pertussis has peptidoglycanase activity required for Ptl-mediated pertussis toxin secretion. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12005182&form=6&db=m Sulfite induces adherence of polymorphonuclear neutrophils to immobilized fibrinogen through activation of Mac-1 beta2-integrin (CD11b/CD18). ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12006259&form=6&db=m [Laboratory diagnosis of pertussis. Role of serology] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12007836&form=6&db=m The cannabinoid agonist DALN positively modulates L-type voltage-dependent calcium-channels in N18TG2 neuroblastoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12008073&form=6&db=m G(z alpha) deficient mice: enzyme levels in the autonomic nervous system, neuronal survival and effect of genetic background. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12010765&form=6&db=m Involvement of 5-HT1B and 5-HT1D receptors in sumatriptan mediated vasocontractile response in rabbit common carotid artery. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12010770&form=6&db=m Physiological antagonism between ventricular beta 1-adrenoceptors and alpha 1-adrenoceptors but no evidence for beta 2- and beta 3-adrenoceptor function in murine heart. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12010824&form=6&db=m Total body irradiation causes profound changes in endothelial traffic molecules for hematopoietic progenitor cell recruitment to bone marrow. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12013509&form=6&db=m Gi-mediated activation of the p42/p44 mitogen-activated protein kinases by receptor mimetic basic secretagogues is abrogated by inhibitors of endocytosis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12014986&form=6&db=m Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12020744&form=6&db=m Phosphatidylinositol 3-kinase mediates inhibitory effect of angiotensin II on sodium/glucose cotransporter in renal epithelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12021394&form=6&db=m Ca(2+)-mobilizing endothelin-A receptors inhibit voltage-gated Ca(2+) influx through G(i/o) signaling pathway in pituitary lactotrophs. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12029481&form=6&db=m Involvement of phosphoinositide turnover in tracheary element differentiation in Zinnia elegans L. cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12030802&form=6&db=m Pretreatment with cholera or pertussis toxin differentially modulates morphine- and beta-endorphin-induced antinociception in the mouse formalin test. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12030804&form=6&db=m The signal transduction pathway causing the synergistic hypertrophic effects of neuropeptide Y and norepinephrine on primary cardiomyocyte. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12031848&form=6&db=m Inhibitory effects of opioids on voltage-dependent Ca(2+) channels and catecholamine secretion in cultured porcine adrenal chromaffin cells. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12031964&form=6&db=m Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12034348&form=6&db=m Metabolic activation of A549 human airway epithelial cells by organic dust: a study based on microphysiometry. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12034656&form=6&db=m Specific beta(2)AR blocker ICI 118,551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12037054&form=6&db=m Multilocus sequence typing of Bordetella pertussis based on surface protein genes. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12037089&form=6&db=m Rapid typing of Bordetella pertussis pertussis toxin gene variants by LightCycler real-time PCR and fluorescence resonance energy transfer hybridization probe melting curve analysis. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12039503&form=6&db=m Vasodilator signals from the ischemic myocardium are transduced to the coronary vascular wall by pertussis toxin-sensitive G proteins: a new experimental method for the analysis of the interaction between the myocardium and coronary vessels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12039947&form=6&db=m Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12039967&form=6&db=m Thrombin receptors activate G(o) proteins in endothelial cells to regulate intracellular calcium and cell shape changes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12039983&form=6&db=m MCP-1 induces inflammatory activation of human tubular epithelial cells: involvement of the transcription factors, nuclear factor-kappaB and activating protein-1. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12042305&form=6&db=m Neurosteroids enhance spontaneous glutamate release in hippocampal neurons. Possible role of metabotropic sigma1-like receptors. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12044785&form=6&db=m Effects of [(pF)Phe(4)]nociceptin/orphanin FQ-(1-13)NH(2) on GTPgamma(35)S binding and cAMP formation in Chinese hamster ovary cells expressing the human nociceptin/orphanin FQ receptor. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12045128&form=6&db=m Lipoxins are potential endogenous antiinflammatory mediators in asthma. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12047905&form=6&db=m Effects of ECL cell extracts and granule/vesicle-enriched fractions from rat oxyntic mucosa on cAMP and IP(3) in rat osteoblast-like cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12047906&form=6&db=m Atrial natriuretic peptide inhibits iodide uptake and thyroglobulin messenger ribonucleic acid expression in cultured bovine thyroid follicles. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12048213&form=6&db=m A novel strategy to engineer functional fluorescent inhibitory G-protein alpha subunits. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12050161&form=6&db=m Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12055093&form=6&db=m Mechanisms of leptin secretion from white adipocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12055094&form=6&db=m ET-1 stimulates ERK signaling pathway through sequential activation of PKC and Src in rat myometrial cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12055130&form=6&db=m Extracellular ATP and UTP activate the protein kinase B/Akt cascade via the P2Y(2) purinoceptor in renal mesangial cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12055206&form=6&db=m Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12058506&form=6&db=m [Macrophage depletion inhibits leukocyte recruitment in experimental melanin-induced uveitis (EMIU)] ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060490&form=6&db=m Monocyte chemoattractant protein-1-induced activation of p42/44 MAPK and c-Jun in murine peritoneal macrophages: a potential pathway for macrophage activation. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060491&form=6&db=m In vitro activation of murine peritoneal macrophages by monocyte chemoattractant protein-1: upregulation of CD11b, production of proinflammatory cytokines, and the signal transduction pathway. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060521&form=6&db=m Norepinephrine-induced calcium mobilization in C6 glioma cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060593&form=6&db=m D2-like receptor-mediated inhibition of Na+-K+-ATPase activity is dependent on the opening of K+ channels. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12063164&form=6&db=m Transforming growth factor-beta1 regulation of growth zone chondrocytes is mediated by multiple interacting pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12063255&form=6&db=m Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12063527&form=6&db=m Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12065491&form=6&db=m Immunogenicity and protective efficacy of neonatal vaccination against Bordetella pertussis in a murine model: evidence for early control of pertussis. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12065583&form=6&db=m Identification of a novel human eicosanoid receptor coupled to G(i/o). ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12065589&form=6&db=m Age increases cardiac Galpha(i2) expression, resulting in enhanced coupling to G protein-coupled receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12065629&form=6&db=m GM1 ganglioside induces phosphorylation and activation of Trk and Erk in brain. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12065743&form=6&db=m Presynaptic muscarinic M(2)-receptor-mediated inhibition of N-type Ca(2+) channels in cultured sphenopalatine ganglion: direct evidence for acetylcholine inhibition of cerebral nitrergic neurogenic vasodilation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12065896&form=6&db=m Characterization of bradykinin receptors in canine cultured corneal epithelial cells: pharmacological and functional studies. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12067898&form=6&db=m Monocyte chemoattractant protein-1 induces proliferation and interleukin-6 production in human smooth muscle cells by differential activation of nuclear factor-kappaB and activator protein-1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12068084&form=6&db=m Agonists activate Gi1 alpha or Gi2 alpha fused to the human mu opioid receptor differently. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12069815&form=6&db=m Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070761&form=6&db=m Signalling components involved in the coupling of alpha 1-adrenoceptors to phospholipase D in neonatal rat cardiac myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12075624&form=6&db=m Adenylyl cyclase and G-proteins in Phytomonas. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12077236&form=6&db=m Pertussis toxin modulates the immune response to neuroantigens injected in incomplete Freund's adjuvant: induction of Th1 cells and experimental autoimmune encephalomyelitis in the presence of high frequencies of Th2 cells. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086672&form=6&db=m betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12087068&form=6&db=m Critical involvement of p38 MAP kinase in pertussis toxin-induced cytoskeletal reorganization and lung permeability. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12088413&form=6&db=m Stimulation of T-Cell activation by CXCL12/stromal cell derived factor-1 involves a G-protein mediated signaling pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12088864&form=6&db=m Mechanisms of bradykinin-induced glucagon release in clonal alpha-cells In-R1-G9: involvement of Ca(2+)-dependent and -independent pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12091343&form=6&db=m C5a stimulates production of plasminogen activator inhibitor-1 in human mast cells and basophils. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12091450&form=6&db=m Lysophosphatidic acid receptor signaling in mammalian retinal pigment epithelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12096069&form=6&db=m Melanin-concentrating hormone depresses L-, N-, and P/Q-type voltage-dependent calcium channels in rat lateral hypothalamic neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12097322&form=6&db=m Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12097326&form=6&db=m The PDZ binding motif of the beta 1 adrenergic receptor modulates receptor trafficking and signaling in cardiac myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12097492&form=6&db=m Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12098668&form=6&db=m Regulation of lysophosphatidic acid receptor-stimulated response by G-protein-coupled receptor kinase-2 and beta-arrestin1 in FRTL-5 rat thyroid cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12099721&form=6&db=m Subtype specific roles of beta-adrenergic receptors in apoptosis of adult rat ventricular myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12100716&form=6&db=m Stimulation of naïve T-cell adhesion and immunological synapse formation by chemokine-dependent and -independent mechanisms. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12101288&form=6&db=m Comparative evaluation of Mycobacterium vaccae as a surrogate cloning host for use in the study of mycobacterial genetics. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12101289&form=6&db=m Changes in the Dutch Bordetella pertussis population in the first 20 years after the introduction of whole-cell vaccines. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12105849&form=6&db=m Lysophosphatidic acid protects and rescues intestinal epithelial cells from radiation- and chemotherapy-induced apoptosis. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12106139&form=6&db=m A G Protein Mediates the Inhibition of the Voltage-Dependent Potassium M Current by Muscarine, LHRH, Substance P and UTP in Bullfrog Sympathetic Neurons. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12106161&form=6&db=m Effects of Pertussis Toxin Suggest a Role for G-Proteins in the Inhibition of Acetylcholine Release from Rat Myenteric Plexus by Opioid and Presynaptic Muscarinic Receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12106163&form=6&db=m Noradrenaline- and Enkephalin-Induced Inhibition of Voltage-Sensitive Calcium Currents in NG108-15 Hybrid Cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12106231&form=6&db=m The Identification and Localization of the Guanine Nucleotide Binding Protein G0 in the Auditory System. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12106302&form=6&db=m Reduction of Potassium Conductances Mediated by Metabotropic Glutamate Receptors in Rat CA3 Pyramidal Cells Does Not Require Protein Kinase C or Protein Kinase A. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12106434&form=6&db=m Endothelin-evoked Release of Arachidonic Acid from Mouse Astrocytes in Primary Culture. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12106606&form=6&db=m Effector coupling of stably transfected human A3 adenosine receptors in CHO cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12107186&form=6&db=m Regulation of angiotensin II-induced G protein signaling by phosducin-like protein. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12108920&form=6&db=m Preconditioning modulates susceptibility to ischemia-induced arrhythmias in the rat heart: the role of alpha-adrenergic stimulation and K(ATP) channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12110374&form=6&db=m Dopamine D(2) receptor-induced COX-2-mediated production of prostaglandin E(2) in D(2)-transfected Chinese hamster ovary cells without simultaneous administration of a Ca(2+)-mobilizing agent. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12110433&form=6&db=m Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12110485&form=6&db=m Evaluation of efficacy in terms of antibody levels and cell-mediated immunity of acellular pertussis vaccines in a murine model of respiratory infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12110510&form=6&db=m LPA is a novel lipid regulator of mesangial cell hexokinase activity and HKII isoform expression. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12111185&form=6&db=m Influence of pertussis toxin on superficial bladder carcinoma in rats. causal interaction,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12111851&form=6&db=m Recovery of deficient cholinergic calcium signaling by adenosine in cultured rat cortical astrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12112372&form=6&db=m RANTES stimulates inflammatory cascades and receptor modulation in murine astrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12114321&form=6&db=m Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during beta2-adrenergic stimulation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12115604&form=6&db=m Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12115614&form=6&db=m A comparative analysis of B cell-mediated myelin oligodendrocyte glycoprotein-experimental autoimmune encephalomyelitis pathogenesis in B cell-deficient mice reveals an effect on demyelination. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12117973&form=6&db=m Quantitative priming with inactivated pertussis toxoid vaccine in the aerosol challenge model. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12121979&form=6&db=m Activation of Go-coupled dopamine D2 receptors inhibits ERK1/ERK2 in pituitary cells. A key step in the transcriptional suppression of the prolactin gene. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12122501&form=6&db=m Pharmacological characterisation of the somatostatin analogue TT-232: effects on neurogenic and non-neurogenic inflammation and neuropathic hyperalgesia. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12123769&form=6&db=m Intracellular beta-blockade: overexpression of Galpha(i2) depresses the beta-adrenergic response in intact myocardium. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12124432&form=6&db=m Activation of nuclear Ca(2+)/calmodulin-dependent protein kinase II and brain-derived neurotrophic factor gene expression by stimulation of dopamine D2 receptor in transfected NG108-15 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126734&form=6&db=m Structure-activity relationship and signal transduction of gamma-MSH peptides in GH3 cells: further evidence for a new melanocortin receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12130504&form=6&db=m Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12130743&form=6&db=m Chronic morphine-induced changes in mu-opioid receptors and G proteins of different subcellular loci in rat brain. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12132038&form=6&db=m Mechanism of retinoic acid induced attenuation of PTH action in UMR 106-01 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12133978&form=6&db=m Leukocyte infiltration, but not neurodegeneration, in the CNS of transgenic mice with astrocyte production of the CXC chemokine ligand 10. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12134231&form=6&db=m Native and genetically inactivated pertussis toxins induce human dendritic cell maturation and synergize with lipopolysaccharide in promoting T helper type 1 responses. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12135597&form=6&db=m Molecular effects of proinsulin C-peptide. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12135674&form=6&db=m Activation of Wiskott-Aldrich syndrome protein and its association with other proteins by stromal cell-derived factor-1alpha is associated with cell migration in a T-lymphocyte line. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12137921&form=6&db=m Role of L-type Ca(2+) channels in pertussis toxin induced antagonism of U50,488H analgesia and hypothermia. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12138095&form=6&db=m Sphingosine 1-phosphate triggers both apoptotic and survival signals for human hepatic myofibroblasts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12142541&form=6&db=m Identification of Bphs, an autoimmune disease locus, as histamine receptor H1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12145108&form=6&db=m Differential coupling of 5-HT(1) receptors to G proteins of the G(i) family. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12145343&form=6&db=m G protein preferences for dopamine D2 inhibition of prolactin secretion and DNA synthesis in GH4 pituitary cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12147609&form=6&db=m Inhibition by brimonidine of forskolin-induced nitrite production in isolated pig ciliary processes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12148697&form=6&db=m 17Beta-estradiol inhibits high-voltage-activated calcium channel currents in rat sensory neurons via a non-genomic mechanism. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12149127&form=6&db=m Involvement of phospholipases D1 and D2 in sphingosine 1-phosphate-induced ERK (extracellular-signal-regulated kinase) activation and interleukin-8 secretion in human bronchial epithelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12150172&form=6&db=m Antibodies to pertussis antigens in pediatric health care workers. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12151186&form=6&db=m Bordetella pertussis PCR: simultaneous targeting of signature sequences. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12151517&form=6&db=m Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12153986&form=6&db=m Lymphocyte trafficking through the blood-brain barrier is dependent on endothelial cell heterotrimeric G-protein signaling. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12160951&form=6&db=m Acetylcholine leads to free radical production dependent on K(ATP) channels, G(i) proteins, phosphatidylinositol 3-kinase and tyrosine kinase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12161029&form=6&db=m Pertussis toxin alters the innate and the adaptive immune responses in a pertussis-dependent model of autoimmunity. causal interaction,ongoing research,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12161432&form=6&db=m G protein-independent activation of an inward Na(+) current by muscarinic receptors in mouse pancreatic beta-cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12163259&form=6&db=m Enhanced sensitisation of mice with diphtheria tetanus acellular pertussis vaccine to local swelling reaction to the booster immunisation. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12165538&form=6&db=m Complement c3a and c5a induce different signal transduction cascades in endothelial cells. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12169651&form=6&db=m Inactivation of enhanced expression of G(i) proteins by pertussis toxin attenuates the development of high blood pressure in spontaneously hypertensive rats. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12172702&form=6&db=m Pertussis toxin converts hyperpolarizations caused by alpha(2)-adrenoceptor agonists containing an imidazoline moiety into depolarizations in MIN 6 cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12175535&form=6&db=m Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase beta. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12175891&form=6&db=m Sympathetic denervation-induced changes in G protein expression in enteric neurons of the guinea pig colon. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12176112&form=6&db=m Modulation of gastric emptying and gastrointestinal transit in rats through intestinal cannabinoid CB(1) receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12181283&form=6&db=m Neuropeptide Y inhibits axonal transport of particles in neurites of cultured adult mouse dorsal root ganglion cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12181434&form=6&db=m Differential activation of Gq/11 and Gi(3) proteins at 5-hydroxytryptamine(2C) receptors revealed by antibody capture assays: influence of receptor reserve and relationship to agonist-directed trafficking. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12181435&form=6&db=m Antibody capture assay reveals bell-shaped concentration-response isotherms for h5-HT(1A) receptor-mediated Galpha(i3) activation: conformational selection by high-efficacy agonists, and relationship to trafficking of receptor signaling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12181436&form=6&db=m Inhibitory effect of fluvastatin on lysophosphatidylcholine-induced nonselective cation current in Guinea pig ventricular myocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12183051&form=6&db=m A rapid, nongenomic action of glucocorticoids in rat B103 neuroblastoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12183648&form=6&db=m The signal transduction of endothelin-1-induced circular smooth muscle cell contraction in cat esophagus. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12186756&form=6&db=m Enhanced GABA(B) receptor in neoplastic rat liver: induction of DNA synthesis by baclofen in hepatocyte cultures. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12188037&form=6&db=m Selective pharmacological inhibitors reveal the role of Syk tyrosine kinase, phospholipase C, phosphatidylinositol-3'-kinase, and p38 mitogen-activated protein kinase in Fc receptor-mediated signaling of chicken heterophil degranulation. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12194965&form=6&db=m Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12198611&form=6&db=m Characterization of a novel chemotactic factor for neutrophils in the bronchial secretions of patients with cystic fibrosis. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12200273&form=6&db=m Purification and immunogenicity of a recombinant Bordetella pertussis S1S3FHA fusion protein expressed by Streptococcus gordonii. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12202519&form=6&db=m Spontaneous induction of immunoregulation by an endogenous retinal antigen. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12204793&form=6&db=m D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12204895&form=6&db=m The role of mitogen-activated protein kinases in eotaxin-induced cytokine production from bronchial epithelial cells. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12205136&form=6&db=m Allopregnanolone activates GABA(A) receptor/Cl(-) channels in a multiphasic manner in embryonic rat hippocampal neurons. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12207323&form=6&db=m Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12209875&form=6&db=m PTH-dependent adenylyl cyclase activation in SaOS-2 cells: passage dependent effects on G protein interactions. causal interaction,diagnostic usage,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12211112&form=6&db=m Diverse chemotactic responses of Dictyostelium discoideum amoebae in the developing (temporal) and stationary (spatial) concentration gradients of folic acid, cAMP, Ca(2+) and Mg(2+). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12213227&form=6&db=m Stimulation of peripheral nociceptor endings by low dose morphine and its signaling mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12213273&form=6&db=m Astrocyte mGlu(2/3)-mediated cAMP potentiation is calcium sensitive: studies in murine neuronal and astrocyte cultures. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12214275&form=6&db=m Inhibition by Wnt-1 or Wnt-3a of nerve growth factor-induced differentiation of PC12 cells is reversed by bisindolylmaleimide-I but not by several other PKC inhibitors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12217410&form=6&db=m Effects of eosinophils on mast cells: a new pathway for the perpetuation of allergic inflammation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12217860&form=6&db=m Localization of IP in rabbit kidney and functional role of the PGI(2)/IP system in cortical collecting duct. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12218055&form=6&db=m Regulation of integrin function by CD47 ligands. Differential effects on alpha vbeta 3 and alpha 4beta1 integrin-mediated adhesion. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12220617&form=6&db=m Substance P-induced activation of p42/44 mitogen-activated protein kinase associated with cell proliferation in human tracheal smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12220620&form=6&db=m Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12220988&form=6&db=m Bordetella pertussis infection of human respiratory epithelial cells up-regulates intercellular adhesion molecule-1 expression: role of filamentous hemagglutinin and pertussis toxin. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12221292&form=6&db=m Gbeta gamma -independent constitutive association of Galpha s with SHP-1 and angiotensin II receptor AT2 is essential in AT2-mediated ITIM-independent activation of SHP-1. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12222964&form=6&db=m Proinsulin C-peptide and its analogues induce intracellular Ca2+ increases in human renal tubular cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12223454&form=6&db=m Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12223528&form=6&db=m Platelet factor 4 induces human natural killer cells to synthesize and release interleukin-8. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12225966&form=6&db=m Duality of G protein-coupled mechanisms for beta-adrenergic activation of NKCC activity in skeletal muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12230122&form=6&db=m Chemokine receptor CXCR2 activates distinct pathways for chemotaxis and calcium mobilization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12231800&form=6&db=m Stomatal Opening Is Induced in Epidermal Peels of Commelina communis L. by GTP Analogs or Pertussis Toxin. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12233813&form=6&db=m Possible involvement of M5 muscarinic receptor in the enhancing actions of the novel gastroprokinetic agent Z-338 on nifedipine-sensitive voltage-dependent Ca2+ currents in guinea pig stomach. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12235216&form=6&db=m Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12235264&form=6&db=m Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12237753&form=6&db=m Stimulation of muscarinic M2 receptors inhibits atrial natriuretic peptide-mediated relaxation in bovine tracheal smooth muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12242272&form=6&db=m Protease-activated receptor-1-mediated DNA synthesis in cardiac fibroblast is via epidermal growth factor receptor transactivation: distinct PAR-1 signaling pathways in cardiac fibroblasts and cardiomyocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12242371&form=6&db=m G Protein Activation Stimulates Phospholipase D Signaling in Plants. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12243776&form=6&db=m Inactivation of Gi proteins induces an antidepressant-like effect in the mouse forced-swimming test. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12244116&form=6&db=m Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12244165&form=6&db=m Endothelial cells stimulate T cell NFAT nuclear translocation in the presence of cyclosporin A: involvement of the wnt/glycogen synthase kinase-3 beta pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12244182&form=6&db=m Mycobacterium avium complex promotes recruitment of monocyte hosts for HIV-1 and bacteria. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12271276&form=6&db=m Serum factors involved in human microvascular endothelial cell morphogenesis. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12297399&form=6&db=m Comparison of the bioactivity of reference preparations for assaying Bordetella pertussis toxin activity in vaccines by the histamine sensitisation and Chinese hamster ovary-cell tests: assessment of validity of expression of activity in terms of protein concentration. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12324626&form=6&db=m Evidence for G-Protein Regulation of Inward K+ Channel Current in Guard Cells of Fava Bean. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12325042&form=6&db=m Endogenous cannabinoid, anandamide, acts as a noncompetitive inhibitor on 5-HT3 receptor-mediated responses in Xenopus oocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12351703&form=6&db=m Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12354227&form=6&db=m Mechanism of association of adenylate cyclase toxin with the surface of Bordetella pertussis: a role for toxin-filamentous haemagglutinin interaction. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12356790&form=6&db=m Priming by grepafloxacin on respiratory burst of human neutrophils: its possible mechanism. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12358781&form=6&db=m GABA is toxic for mouse striatal neurones through a transporter-mediated process. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12358794&form=6&db=m Matrix metalloproteinase-1 activates a pertussis toxin-sensitive signaling pathway that stimulates the release of matrix metalloproteinase-9. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12359224&form=6&db=m Sphingosine kinase-dependent directional migration of leukocytes in response to phorbol ester. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12359633&form=6&db=m Purines and pyrimidines are not involved in NANC relaxant responses in the rabbit vaginal wall. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12361678&form=6&db=m Regulation of phospholipase D in human placental trophoblasts by the P(2) purinergic receptor. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12369781&form=6&db=m Involvement of Rho and p38 MAPK in endothelin-1-induced expression of PGHS-2 mRNA in osteoblast-like cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12370392&form=6&db=m Thrombin induces mast cell adhesion to fibronectin: evidence for involvement of protease-activated receptor-1. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12376532&form=6&db=m P2Y purinoceptors are responsible for oscillatory fluid flow-induced intracellular calcium mobilization in osteoblastic cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12376552&form=6&db=m Growth hormone-induced diacylglycerol and ceramide formation via Galpha i3 and Gbeta gamma in GH4 pituitary cells. Potentiation by dopamine-D2 receptor activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12376566&form=6&db=m Thrombospondin-1 differentially induces chemotaxis and DNA synthesis of human venous smooth muscle cells at the receptor-binding level. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12377392&form=6&db=m Role of Gi proteins in the antidepressant-like effect of amitriptyline and clomipramine. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12377738&form=6&db=m Pulsatile flow-induced angiogenesis: role of G(i) subunits. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12377954&form=6&db=m Rho family small GTPases control migration of hematopoietic progenitor cells into multicellular spheroids of bone marrow stroma cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12379266&form=6&db=m Postsynaptic action mechanism of somatostatin on the membrane excitability in spinal substantia gelatinosa neurons of juvenile rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12379743&form=6&db=m Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12381685&form=6&db=m Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12382069&form=6&db=m Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12384490&form=6&db=m G protein modulates thyroid hormone-induced Na(+) channel activation in ventricular myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12385032&form=6&db=m Bordetella pertussis toxin induces the release of inflammatory cytokines and dendritic cell activation in whole blood: impaired responses in human newborns. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12388113&form=6&db=m Granulocyte colony-stimulating factor promotes adhesion of neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12388115&form=6&db=m Signal transduction of somatostatin in human B lymphoblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12388194&form=6&db=m Activation of group II mGlu receptors inhibits voltage-gated Ca2+ currents in myenteric neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12388631&form=6&db=m P2Y-receptors mediating an inhibition of the evoked entry of calcium through N-type calcium channels at neuronal processes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12389644&form=6&db=m Experimental autoimmune encephalomyelitis in the Wistar rat: dependence of MBP-specific T cell responsiveness on B7 costimulation. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12391196&form=6&db=m Monocyte chemoattractant protein-1 selectively inhibits the acquisition of CD40 ligand-dependent IL-12-producing capacity of monocyte-derived dendritic cells and modulates Th1 immune response. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12391244&form=6&db=m Platelet-activating factor activates two distinct effector pathways in human eosinophils. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12391272&form=6&db=m Beta(2)-adrenergic receptor lacking the cyclic AMP-dependent protein kinase consensus sites fully activates extracellular signal-regulated kinase 1/2 in human embryonic kidney 293 cells: lack of evidence for G(s)/G(i) switching. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12391277&form=6&db=m Signaling pathway from the human adenosine A(3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393053&form=6&db=m Ceramide 1-(2-cyanoethyl) phosphate enhances store-operated Ca2+ entry in thyroid FRTL-5 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393093&form=6&db=m Sepsis causes presynaptic histamine H3 and alpha2-adrenergic dysfunction in canine myocardium. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393391&form=6&db=m Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393568&form=6&db=m The spleen is a major site of megakaryopoiesis following transplantation of murine hematopoietic stem cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393875&form=6&db=m Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393898&form=6&db=m Chemokine-independent preference for T-helper-1 cells in transendothelial migration. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12399623&form=6&db=m Differential expression of MCP-1 and its receptor CCR2 in glucose primed human mesangial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12400874&form=6&db=m Effects and mechanisms of melatonin on inflammatory and immune responses of adjuvant arthritis rat. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12401881&form=6&db=m Class A scavenger receptors mediate cell adhesion via activation of G(i/o) and formation of focal adhesion complexes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12403070&form=6&db=m On technological and immunological benefits of multivalent single-injection microsphere vaccines. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12412634&form=6&db=m Dieldrin induces human neutrophil superoxide production via protein kinases C and tyrosine kinases. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12414810&form=6&db=m Stromal cell-derived factor-1alpha induces tube-like structure formation of endothelial cells through phosphoinositide 3-kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12414904&form=6&db=m Characterization of human chorionic gonadotropin as a novel angiogenic factor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12416995&form=6&db=m Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells: evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12421353&form=6&db=m Identity of adenylyl cyclase isoform determines the G protein mediating chronic opioid-induced adenylyl cyclase supersensitivity. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12421587&form=6&db=m Chinese hamster ovary (CHO) cell clustering does not correlate with in vivo histamine-sensitization when measuring residual activity of aldehyde-treated pertussis toxin (PT). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12423254&form=6&db=m Galanin inhibits tyrosine hydroxylase expression in midbrain dopaminergic neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12424318&form=6&db=m Angiotensin AT(1)-receptors depolarize neonatal spinal motoneurons and other ventral horn neurons via two different conductances. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12426323&form=6&db=m Pertussis toxin-insensitive activation of the heterotrimeric G-proteins Gi/Go by the NG108-15 G-protein activator. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12427829&form=6&db=m Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12429528&form=6&db=m B-oligomer of pertussis toxin inhibits HIV-1 LTR-driven transcription through suppression of NF-kappaB p65 subunit activity. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12429718&form=6&db=m Pertussis toxin and the adenylate cyclase toxin from Bordetella pertussis activate human monocyte-derived dendritic cells and dominantly inhibit cytokine production through a cAMP-dependent pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12431910&form=6&db=m Diacylglycerol and ceramide formation induced by dopamine D2S receptors via Gbeta gamma -subunits in Balb/c-3T3 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12433334&form=6&db=m [Pertussis outbreak in a poorly immunized community] diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12433842&form=6&db=m Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12434015&form=6&db=m Cell surface CCR5 density determines the postentry efficiency of R5 HIV-1 infection. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12435805&form=6&db=m A3 adenosine receptors in human astrocytoma cells: agonist-mediated desensitization, internalization, and down-regulation. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12437585&form=6&db=m Group-I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to extracellular signal-regulated kinase (ERK) activation via distinct, but overlapping, signalling pathways. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12441353&form=6&db=m Pro-collagen I COOH-terminal trimer induces directional migration and metalloproteinases in breast cancer cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12442020&form=6&db=m Immunogenicity after one, two or three doses and impact on the antibody response to coadministered antigens of a nonavalent pneumococcal conjugate vaccine in infants of Soweto, South Africa. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12443661&form=6&db=m Detection of residual pertussis toxin in vaccines using a modified ribosylation assay. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12445973&form=6&db=m Mechanisms involved in morphine-induced activation of synaptosomal Na+,K+-ATPase. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12446603&form=6&db=m The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3 kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12447991&form=6&db=m Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12456817&form=6&db=m Gating properties of GIRK channels activated by Galpha(o)- and Galpha(i)-coupled muscarinic m2 receptors in Xenopus oocytes: the role of receptor precoupling in RGS modulation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12460891&form=6&db=m 5(S)-Hydroxy-6,8,11,14-E,Z,Z,Z-eicosatetraenoate stimulates PC3 cell signaling and growth by a receptor-dependent mechanism. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12465045&form=6&db=m Loss of microglial ramification in microglia-astrocyte cocultures: involvement of adenylate cyclase, calcium, phosphatase, and Gi-protein systems. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12467690&form=6&db=m Pertussis of adults and infants. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12467878&form=6&db=m Role of presynaptic 5-HT1A and 5-HT3 receptors in modulation of synaptic GABA transmission in dissociated rat basolateral amygdala neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12470213&form=6&db=m Spinorphin as an endogenous inhibitor of enkephalin-degrading enzymes: roles in pain and inflammation. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12471263&form=6&db=m Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12471617&form=6&db=m Wnt-5a and G-protein signaling are required for collagen-induced DDR1 receptor activation and normal mammary cell adhesion. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12472883&form=6&db=m Induction of COX-2 and reactive gliosis by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signalling. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12477719&form=6&db=m Cooperation of Gq, Gi, and G12/13 in protein kinase D activation and phosphorylation induced by lysophosphatidic acid. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12480163&form=6&db=m Facilitative interactions between vasoactive intestinal polypeptide and receptor type-selective opioids: implications for sensory afferent regulation of spinal opioid action. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12482885&form=6&db=m Activation of a PTX-insensitive G protein is involved in histamine-induced recombinant M-channel modulation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12485162&form=6&db=m Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12486156&form=6&db=m Pertussis toxin-induced reversible encephalopathy dependent on monocyte chemoattractant protein-1 overexpression in mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12488330&form=6&db=m Regulation of oxytocin receptor expression in cultured human myometrial cells by fetal bovine serum and lysophospholipids. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12488540&form=6&db=m Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12488551&form=6&db=m Specificity of metabotropic glutamate receptor 2 coupling to G proteins. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12489019&form=6&db=m Possible involvement of C-C chemokines in functional augmentation of adhesion molecules in asthmatic patients. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12491795&form=6&db=m [Effects of sphingosine-1-phosphate, a lipid mediator, in cardiovascular tissues] causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12492954&form=6&db=m Muscarinic M2 receptors inhibit Ca2+-activated K+ channels in rat bladder smooth muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12496284&form=6&db=m The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12496427&form=6&db=m Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12499047&form=6&db=m Concentration-dependent dual effect of anandamide on sensory neuropeptide release from isolated rat tracheae. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12500974&form=6&db=m Lipoxin A4 stimulates a cytosolic Ca2+ increase in human bronchial epithelium. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12504804&form=6&db=m Cooperative enhancement of insulinotropic action of GLP-1 by acetylcholine uncovers paradoxical inhibitory effect of beta cell muscarinic receptor activation on adenylate cyclase activity. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12504925&form=6&db=m Acetyl-l-carnitine induces muscarinic antinocieption in mice and rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12505529&form=6&db=m Agonist-specific down-regulation of the human delta-opioid receptor. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12507769&form=6&db=m Autoreactive T cells promote post-traumatic healing in the central nervous system. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12508050&form=6&db=m Dihydropyridine receptors as voltage sensors for a depolarization-evoked, IP3R-mediated, slow calcium signal in skeletal muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12509806&form=6&db=m Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12514186&form=6&db=m Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12514203&form=6&db=m Opposite action of beta1- and beta2-adrenergic receptors on Ca(V)1 L-channel current in rat adrenal chromaffin cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12514329&form=6&db=m SR144528 as inverse agonist of CB2 cannabinoid receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12515326&form=6&db=m Pertussis toxin-sensitive G proteins mediate the inhibition of basal phosphoinositide metabolism caused by adenosine A1 receptors in rat hippocampal slices. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12519884&form=6&db=m CXC chemokine receptor 4 expression and function in human anaplastic thyroid cancer cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12522085&form=6&db=m Demonstration of functional M3-muscarinic receptors in ventricular cardiomyocytes of adult rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12522092&form=6&db=m Pertussis toxin sensitive and insensitive effects of adenosine and carbachol in murine atria overexpressing A(1)-adenosine receptors. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12524145&form=6&db=m Prostanoid EP3 and TP receptors-mediated inhibition of noradrenaline release from the isolated rat stomach. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12524663&form=6&db=m Regulation of leptin release by insulin, glucocorticoids, G(i)-coupled receptor agonists, and pertussis toxin in adipocytes and adipose tissue explants from obese humans in primary culture. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12527340&form=6&db=m Dimethylsphingosine increases cytosolic calcium and intracellular pH in human T lymphocytes. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12531494&form=6&db=m Mechanisms involved in the antinociception caused by compound MV8612 isolated from Mandevilla velutina in mice. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12531543&form=6&db=m Lysophosphatidic acid as a novel cell survival/apoptotic factor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12531644&form=6&db=m B- and T-cell responses to the mycobacterium surface antigen PstS-1 in the respiratory tract and adjacent tissues. Role of adjuvants and routes of immunization. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12535202&form=6&db=m Pertussis toxin-sensitive secretory phospholipase A2 expression and motility in activated primary human keratinocytes. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12535664&form=6&db=m The canine mast cell activation via CRP. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12538398&form=6&db=m Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12538595&form=6&db=m Activation of the mitogen-activated protein kinases Erk1/2 by erythropoietin receptor via a G(i )protein beta gamma-subunit-initiated pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12540532&form=6&db=m Coupling of the nucleotide P2Y4 receptor to neuronal ion channels. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12551992&form=6&db=m Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12552097&form=6&db=m beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12552127&form=6&db=m Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12555662&form=6&db=m Targeting CLA/E-selectin interactions prevents CCR4-mediated recruitment of human Th2 memory cells to human skin in vivo. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12556526&form=6&db=m Mastoparan selectively activates phospholipase D2 in cell membranes. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12557151&form=6&db=m Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12557751&form=6&db=m Acute-phase, but not constitutive serum amyloid A (SAA) is chemotactic for cultured human aortic smooth muscle cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12558330&form=6&db=m Kinetics of the IgG antibody response to pertussis toxin after infection with B. pertussis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12558985&form=6&db=m Recombinant human serotonin 5A receptors stably expressed in C6 glioma cells couple to multiple signal transduction pathways. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12559089&form=6&db=m Rapid inhibitory effects of corticosterone on calcium influx in rat dorsal root ganglion neurons. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12560086&form=6&db=m Sphingosine-1-phosphate stimulates cortisol secretion. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12560106&form=6&db=m D-2-amino-5-phosphonopentanoic acid inhibits intrathecal pertussis toxin-induced thermal hyperalgesia and protein kinase Cgamma up-regulation. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12562507&form=6&db=m Somatostatin receptors (sst2) are coupled to Go and modulate GTPase activity in the rabbit retina. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12562529&form=6&db=m Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12566419&form=6&db=m Integrin-dependence of lymphocyte entry into the splenic white pulp. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12569410&form=6&db=m Nod factors activate both heterotrimeric and monomeric G-proteins in Vigna unguiculata (L.) Walp. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12571279&form=6&db=m Microtubule-disruption-induced and chemotactic-peptide-induced migration of human neutrophils: implications for differential sets of signalling pathways. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12573135&form=6&db=m Angiotensin II induces a rapid and transient increase of reactive oxygen species. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12573468&form=6&db=m Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12573469&form=6&db=m Toosendanin induces outgrowth of neuronal processes and apoptosis in PC12 cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12573726&form=6&db=m Intrathecal pertussis toxin induces thermal hyperalgesia: involvement of excitatory and inhibitory amino acids. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12574336&form=6&db=m Pertussis toxin enhances Th1 responses by stimulation of dendritic cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12574419&form=6&db=m Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12574519&form=6&db=m Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12576222&form=6&db=m Signalling pathways involved in the chemotactic activity of CXCL12 in cultured rat cerebellar neurons and CHP100 neuroepithelioma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12576295&form=6&db=m Urokinase potentiates PDGF-induced chemotaxis of human airway smooth muscle cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12576304&form=6&db=m Erk1/2- and p38 MAP kinase-dependent phosphorylation and activation of cPLA2 by m3 and m2 receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12578116&form=6&db=m Impairment of beta-adrenergic signaling in healthy peripheral blood mononuclear cells exposed to serum from patients with septic shock: involvement of the inhibitory pathway of adenylyl cyclase stimulation. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12579890&form=6&db=m [Effects of praeruptorin C on cell hypertrophy, intracellular [Ca2+]i, nitric oxide and signal transduction in isolated hypertrophied rat smooth muscle cells induced by angiotensin II] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12581882&form=6&db=m A Galphas protein-coupled membrane receptor, distinct from the classical oestrogen receptor, transduces rapid effects of oestradiol on [Ca2+]i in female rat distal colon. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12586615&form=6&db=m Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12588763&form=6&db=m Lysophosphatidic acid induction of tissue factor expression in aortic smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12588974&form=6&db=m Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12591009&form=6&db=m Effects of sphingosine-1-phosphate and lysophosphatidic acid on human osteoblastic cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12591092&form=6&db=m Activation of muscarinic m5 receptors inhibits recombinant KCNQ2/KCNQ3 K+ channels expressed in HEK293T cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12591125&form=6&db=m Intra-accumbens pertussis toxin sensitizes rats to the locomotor activating effects of a single cocaine challenge. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12591162&form=6&db=m The mu opioid agonist DAMGO stimulates cAMP production in SK-N-SH cells through a PLC-PKC-Ca++ pathway. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12591945&form=6&db=m An agonist-induced switch in G protein coupling of the gonadotropin-releasing hormone receptor regulates pulsatile neuropeptide secretion. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12595282&form=6&db=m Mechanism of thrombin-induced vasodilation in human coronary arterioles. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12595315&form=6&db=m The role of G-protein signaling in hematopoietic stem/progenitor cell mobilization. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12595443&form=6&db=m Analysis of the role of Bphs/Hrh1 in the genetic control of responsiveness to pertussis toxin. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12595447&form=6&db=m Reduced glutathione is required for pertussis toxin secretion by Bordetella pertussis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12595502&form=6&db=m Activation of the G(i) heterotrimeric G protein by ANCA IgG F(ab')2 fragments is necessary but not sufficient to stimulate the recruitment of those downstream mediators used by intact ANCA IgG. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12595757&form=6&db=m Bradykinin B2 receptor-mediated proliferation via activation of the Ras/Raf/MEK/MAPK pathway in rat vascular smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12598941&form=6&db=m [Effect of interleukin-2 on the activity of Ca(2+)ATPase and Na(+)/K(+)ATPase of sarcoplasmic reticulum and sarcolemma] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12604091&form=6&db=m GABAB receptor-mediated presynaptic potentiation of ATP ionotropic receptors in rat midbrain synaptosomes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12604350&form=6&db=m Regulation of leukotriene-dependent induction of cyclooxygenase-2 and Bcl-2. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12604641&form=6&db=m Zona pellucida induces activation of phospholipase A2 during acrosomal exocytosis in guinea pig spermatozoa. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12606407&form=6&db=m Evidence suggesting that the mouse sperm acrosome reaction initiated by the zona pellucida involves an alpha7 nicotinic acetylcholine receptor. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12606648&form=6&db=m alpha 2-Adrenoceptors potentiate angiotensin II- and vasopressin-induced renal vasoconstriction in spontaneously hypertensive rats. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12606753&form=6&db=m Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12606754&form=6&db=m Differential requirement of G alpha12, G alpha13, G alphaq, and G beta gamma for endothelin-1-induced c-Jun NH2-terminal kinase and extracellular signal-regulated kinase activation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12606780&form=6&db=m Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12607128&form=6&db=m Impact of hypercholesterolemia on acidosis-induced coronary microvascular dilation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12609846&form=6&db=m L-selectin stimulation enhances functional expression of surface CXCR4 in lymphocytes: implications for cellular activation during adhesion and migration. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12614848&form=6&db=m Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12616493&form=6&db=m Human fractalkine mediates leukocyte adhesion but not capture under physiological shear conditions; a mechanism for selective monocyte recruitment. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12616990&form=6&db=m Protein kinase C isoforms and A1 adenosine receptors in porcine coronary smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12616995&form=6&db=m Pharmacological characterization of a UTP-sensitive P2Y nucleotide receptor in organ cultured coronary arteries. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12618211&form=6&db=m Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12618218&form=6&db=m Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12623057&form=6&db=m Collaborative study for the establishment of a European Phamacopoeia Biological reference preparation for Bordetella pertussis mouse antiserum for serological potency testing of acellular pertussis vaccines. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12623301&form=6&db=m Modulation of myocardial contractility by lysophosphatidic acid (LPA). therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12624527&form=6&db=m The stimulatory effect of cannabinoids on calcium uptake is mediated by Gs GTP-binding proteins and cAMP formation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12626332&form=6&db=m Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12626562&form=6&db=m Proline-rich tyrosine kinase 2 and Rac activation by chemokine and integrin receptors controls NK cell transendothelial migration. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12626656&form=6&db=m Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12629172&form=6&db=m Metabotropic glutamate receptor activation enhances the activities of two types of Ca2+-activated k+ channels in rat hippocampal astrocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12637339&form=6&db=m High density lipoprotein-induced angiogenesis requires the activation of Ras/MAP kinase in human coronary artery endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12637351&form=6&db=m Altered sinus nodal and atrioventricular nodal function in freely moving mice overexpressing the A1 adenosine receptor. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12637559&form=6&db=m High density lipoprotein-induced signaling of the MAPK pathway involves scavenger receptor type BI-mediated activation of Ras. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12637575&form=6&db=m Induction of adherent activity in mastocytoma P-815 cells by the cooperation of two prostaglandin E2 receptor subtypes, EP3 and EP4. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12639714&form=6&db=m Interleukin-8 production induced by the endozepine triakontatetraneuropeptide in human neutrophils: role of calcium and pharmacological investigation of signal transduction pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12642388&form=6&db=m Protease-activated receptor (PAR)-independent growth and pro-inflammatory actions of thrombin on human cultured airway smooth muscle. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12642399&form=6&db=m Dopamine D2-like receptor-mediated opening of K+ channels in opossum kidney cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12645948&form=6&db=m CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12646160&form=6&db=m Active transducin alpha subunit carries PDE6 to detergent-resistant membranes in rod photoreceptor outer segments. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12646285&form=6&db=m Mu-opioid receptor activation prevents apoptosis following serum withdrawal in differentiated SH-SY5Y cells and cortical neurons via phosphatidylinositol 3-kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12646312&form=6&db=m Melatonin inhibition of nicotine-stimulated dopamine release in PC12 cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12646616&form=6&db=m The mechanism of CD47-dependent killing of T cells: heterotrimeric Gi-dependent inhibition of protein kinase A. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12648236&form=6&db=m Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12649078&form=6&db=m Modulation of protein phosphatase 2a by adenosine A1 receptors in cardiomyocytes: role for p38 MAPK. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12649322&form=6&db=m Calpain regulates neutrophil chemotaxis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12650862&form=6&db=m Nongenomic mechanism of glucocorticoid inhibition of bradykinin-induced calcium influx in PC12 cells: possible involvement of protein kinase C. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12651916&form=6&db=m Chick RGS2L demonstrates concentration-dependent selectivity for pertussis toxin-sensitive and -insensitive pathways that inhibit L-type Ca2+ channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12654855&form=6&db=m Mucosal immunization with a genetically engineered pertussis toxin S1 fragment-cholera toxin subunit B chimeric protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12655167&form=6&db=m TNF-alpha rapidly antagonizes the beta-adrenergic responses of the chloride current in guinea-pig ventricular myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12655177&form=6&db=m A novel G protein alpha subunit in embryo of the ascidian, Halocynthia roretzi. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12657848&form=6&db=m Dual effects of hexanol and halothane on the regulation of calcium sensitivity in airway smooth muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12659167&form=6&db=m Neuropeptide Y secretion from bovine chromaffin cells inhibits cyclic AMP accumulation. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12663756&form=6&db=m Constitutive inositol phosphate formation in cytomegalovirus-infected human fibroblasts is due to expression of the chemokine receptor homologue pUS28. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12665520&form=6&db=m Inhibitory role of the somatostatin receptor SST2 on the intracrine-regulated cell proliferation induced by the 210-amino acid fibroblast growth factor-2 isoform: implication of JAK2. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12665541&form=6&db=m Nocistatin and prepro-nociceptin/orphanin FQ 160-187 cause nociception through activation of Gi/o in capsaicin-sensitive and of Gs in capsaicin-insensitive nociceptors, respectively. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12665564&form=6&db=m Permeabilization in a cerebral endothelial barrier model by pertussis toxin involves the PKC effector pathway and is abolished by elevated levels of cAMP. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12668209&form=6&db=m Hypothalamic administration of cAMP agonist/PKA activator inhibits both schedule feeding and NPY-induced feeding in rats. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12668867&form=6&db=m Dependence of prolactin release on coupling between Ca(2+) mobilization and voltage-gated Ca(2+) influx pathways in rat lactotrophs. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12672049&form=6&db=m The neutrophil-activating protein of Helicobacter pylori (HP-NAP) activates the MAPK pathway in human neutrophils. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12675152&form=6&db=m Modulatory role of adenosine receptors in insect motor nerve terminals. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12675921&form=6&db=m Further evidence that the CCK2 receptor is coupled to two transduction pathways using site-directed mutagenesis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12676354&form=6&db=m Expression of adenylyl cyclase isoforms in neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12676735&form=6&db=m Mechanism of activation of ERK and H-K-ATPase by isoproterenol in rat cortical collecting duct. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12678225&form=6&db=m Developments in reduction and replacement of in vivo toxicity and potency tests for pertussis vaccines. diagnostic usage,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12684213&form=6&db=m LPA protects intestinal epithelial cells from apoptosis by inhibiting the mitochondrial pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12684222&form=6&db=m Protein acylation in the inhibition of insulin secretion by norepinephrine, somatostatin, galanin, and PGE2. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12684524&form=6&db=m The M2 muscarinic G-protein-coupled receptor is voltage-sensitive. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12686728&form=6&db=m Endothelin ET A- and ET B-receptor-mediated inhibition of noradrenaline release from isolated rat stomach. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12689946&form=6&db=m Eotaxin-3 is a natural antagonist for CCR2 and exerts a repulsive effect on human monocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12690115&form=6&db=m Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12694392&form=6&db=m Secretoneurin promotes pertussis toxin-sensitive neurite outgrowth in cerebellar granule cells. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12694864&form=6&db=m Comparison of the pharmacological antagonism of M2 and M3 muscarinic receptors expressed in isolation and in combination. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12695302&form=6&db=m Low-density lipoprotein in hypercholesterolemic human plasma induces vascular endothelial cell apoptosis by inhibiting fibroblast growth factor 2 transcription. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12695532&form=6&db=m Identification of a compound that directly stimulates phospholipase C activity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12695561&form=6&db=m Role of macrophage inflammatory protein-3alpha and its ligand CCR6 in rheumatoid arthritis. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12701623&form=6&db=m Implication of Galpha i proteins and Src tyrosine kinases in endotoxin-induced signal transduction events and mediator production. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12702572&form=6&db=m G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12702704&form=6&db=m Effects of orexin (hypocretin) on GIRK channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12706231&form=6&db=m Protein kinase C activation generates superoxide and contributes to impairment of cerebrovasodilation induced by G protein activation after brain injury. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12706678&form=6&db=m Analogous IgG subclass response to pertussis toxin in vaccinated children, healthy or affected by whooping cough. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12708090&form=6&db=m Bordetella pertussis and Bordetella parapertussis infection in an Austrian pediatric outpatient clinic. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12710970&form=6&db=m The beta2-adrenergic receptor specifically sequesters Gs but signals through both Gs and Gi/o in rat sympathetic neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12711605&form=6&db=m 2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12711624&form=6&db=m Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12711626&form=6&db=m Pharmacological discrimination between muscarinic receptor signal transduction cascades with bethanechol chloride. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12711635&form=6&db=m Evidence for cross-talk between M2 and M3 muscarinic acetylcholine receptors in the regulation of second messenger and extracellular signal-regulated kinase signalling pathways in Chinese hamster ovary cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12711637&form=6&db=m Cardiac-specific overexpression of human beta2 adrenoceptors in mice exposes coupling to both Gs and Gi proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12713644&form=6&db=m Alpha2-adrenoreceptor activation inhibits LTP and LTD in the basolateral amygdala: involvement of Gi/o-protein-mediated modulation of Ca2+-channels and inwardly rectifying K+-channels in LTD. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12714438&form=6&db=m Rapid activation of Ras by fluid flow is mediated by Galpha(q) and Gbetagamma subunits of heterotrimeric G proteins in human endothelial cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12716436&form=6&db=m Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12717674&form=6&db=m [Kainate receptors. Their function in the regulation of GABAergic synaptic transmission in the hippocampus] therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12719761&form=6&db=m [Ca2+]i oscillations induced by high [K+]o in acetylcholine-stimulated rat submandibular acinar cells: regulation by depolarization, cAMP and pertussis toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12721327&form=6&db=m Expression and molecular pharmacology of the mouse CRTH2 receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12724327&form=6&db=m GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12726892&form=6&db=m Internalization and recycling of human mu opioid receptors expressed in Sf9 insect cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12727981&form=6&db=m Absence of exon 10 of the human luteinizing hormone (LH) receptor impairs LH, but not human chorionic gonadotropin action. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12728086&form=6&db=m Immunogenicity of a three-component acellular pertussis vaccine administered at birth. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12729461&form=6&db=m Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12729560&form=6&db=m Activation of Gbetagamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12730102&form=6&db=m Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID mice. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12730147&form=6&db=m TNF-[alpha] modulates murine tracheal rings responsiveness to G-protein-coupled receptor agonists and KCl. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12730329&form=6&db=m Lysophosphatidic acid signals through mitogen-activated protein kinase-extracellular signal regulated kinase in ovarian theca cells expressing the LPA1/edg2-receptor: involvement of a nonclassical pathway? therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12732355&form=6&db=m Molecular mechanisms for the activation of Ca2+-permeable nonselective cation channels by endothelin-1 in C6 glioma cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12733823&form=6&db=m Bradykinin induced a positive chronotropic effect via stimulation of T- and L-type calcium currents in heart cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12733988&form=6&db=m Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12736905&form=6&db=m Experimental researches on the role of phosphoinositide-specific phospholipase C in 4-hydroxynonenal induced exocytosis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12738812&form=6&db=m Interleukin-8 secreted by endothelial cells induces chemotaxis of melanoma cells through the chemokine receptor CXCR1. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12742067&form=6&db=m Evidence that the appressorial development in barley powdery mildew is controlled by MAP kinase activity in conjunction with the cAMP pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12742228&form=6&db=m Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12742515&form=6&db=m Effects of ginsenoside on G protein-coupled inwardly rectifying K(+) channel activity expressed in Xenopus oocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12742827&form=6&db=m Sphingosine 1-phosphate and control of vascular tone. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12744863&form=6&db=m Modifications of the catalytic and binding subunits of pertussis toxin by formaldehyde: effects on toxicity and immunogenicity. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12744872&form=6&db=m Seroprevalence of Bordetella pertussis antibodies in Flanders (Belgium). diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12744905&form=6&db=m Novel configurations of high molecular weight species of the pertussis toxin vaccine component. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12746258&form=6&db=m Angiotensin blocks substance P release from renal sensory nerves by inhibiting PGE2-mediated activation of cAMP. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12748744&form=6&db=m Mechanisms of opioid delta (delta) and kappa ( kappa) receptors' cardioprotection in ischaemic preconditioning in a rat model of myocardial infarction. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12750173&form=6&db=m CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12750877&form=6&db=m Role of beta 1- and beta 2-adrenoceptors in hypertrophic and apoptotic effects of noradrenaline and adrenaline in adult rat ventricular cardiomyocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12752108&form=6&db=m Human bone marrow endothelial cells elaborate non-stromal-cell-derived factor-1 (SDF-1)-dependent chemoattraction and SDF-1-dependent transmigration of haematopoietic progenitors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12753074&form=6&db=m Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12759139&form=6&db=m Leukotactin-1-induced ERK activation is mediated via Gi/Go protein/PLC/PKC delta/Ras cascades in HOS cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12759218&form=6&db=m Angiotensin II phosphorylation of extracellular signal-regulated kinases in rat anterior pituitary cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12761344&form=6&db=m Developmental changes in beta2-adrenergic receptor signaling in ventricular myocytes: the role of Gi proteins and caveolae microdomains. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12761346&form=6&db=m Characterization of a Ca2+ response to both UTP and ATP at human P2Y11 receptors: evidence for agonist-specific signaling. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12763599&form=6&db=m Endogenous somatostatin receptors mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12763637&form=6&db=m Catestatin (CgA344-364) stimulates rat mast cell release of histamine in a manner comparable to mastoparan and other cationic charged neuropeptides. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12766252&form=6&db=m The endogenous cannabinoid anandamide inhibits alpha7 nicotinic acetylcholine receptor-mediated responses in Xenopus oocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12766833&form=6&db=m Molecular typing of Bordetella pertussis isolates recovered from Belgian children and their household members. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12768775&form=6&db=m [Thiol reagent thimerosal-induced Ca2+ mobilization in isolated guinea pig cochlear outer hair cells] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12773483&form=6&db=m Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12775579&form=6&db=m High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12782184&form=6&db=m Cannabinoid CB1 receptor-mediated inhibition of glutamate release from rat hippocampal synaptosomes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12782194&form=6&db=m S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12784121&form=6&db=m The human D2 dopamine receptor synergizes with the A2A adenosine receptor to stimulate adenylyl cyclase in PC12 cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12785724&form=6&db=m Sphingosine 1-phosphate antagonizes human neutrophil apoptosis via p38 mitogen-activated protein kinase. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12787833&form=6&db=m Effects of 8-iso-prostaglandin E2 and 8-iso-prostaglandin F2 alpha on the release of noradrenaline from the isolated rat stomach. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12795614&form=6&db=m Mitogen-induced activation of Na+/H+ exchange in vascular smooth muscle cells involves janus kinase 2 and Ca2+/calmodulin. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12798493&form=6&db=m 1alpha,25(OH)2D3 causes a rapid increase in phosphatidylinositol-specific PLC-beta activity via phospholipase A2-dependent production of lysophospholipid. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12803616&form=6&db=m An apoplastic mechanism for short-term effects of rare earth elements at lower concentrations. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12805072&form=6&db=m Oxidized phospholipid-induced endothelial cell/monocyte interaction is mediated by a cAMP-dependent R-Ras/PI3-kinase pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12805086&form=6&db=m Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12805480&form=6&db=m Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12810550&form=6&db=m Extracellular signal-regulated kinase 1/2 activation by myometrial oxytocin receptor involves Galpha(q)Gbetagamma and epidermal growth factor receptor tyrosine kinase activation. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12810818&form=6&db=m OxLDL induces mitogen-activated protein kinase activation mediated via PI3-kinase/Akt in vascular smooth muscle cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12811846&form=6&db=m Cell-surface bound pertussis toxin induces polyclonal T cell responses with high levels of interferon-gamma in the absence of interleukin-12. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12812995&form=6&db=m A role of protein kinase C mu in signalling from the human adenosine A1 receptor to the nucleus. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12816871&form=6&db=m CC chemokine ligand 20 partially controls adhesion of naive B cells to activated endothelial cells under shear stress. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12819231&form=6&db=m Bimodal acute effects of A1 adenosine receptor activation on Na+/H+ exchanger 3 in opossum kidney cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12819273&form=6&db=m Angiotensin II-induced inotropism requires an endocardial endothelium-nitric oxide mechanism in the in-vitro heart of Anguilla anguilla. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12819297&form=6&db=m Regulation of cyclic adenosine 3',5'-monophosphate signaling and pulsatile neurosecretion by Gi-coupled plasma membrane estrogen receptors in immortalized gonadotropin-releasing hormone neurons. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12821130&form=6&db=m Ras/Raf1-dependent signal in sphingosine-1-phosphate-induced tube formation in human coronary artery endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12821136&form=6&db=m Constitutive precoupling to G(i) and increased agonist potency in the alpha(2B)-adrenoceptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824249&form=6&db=m Neutralizing tumor necrosis factor-alpha activity suppresses activation of infiltrating macrophages in experimental autoimmune uveoretinitis. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12827359&form=6&db=m Functional coupling between heterologously expressed dopamine D(2) receptors and KCNQ channels. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12829723&form=6&db=m The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12832096&form=6&db=m Cardiac role of frog ANF: negative inotropism and binding sites in Rana esculenta. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12836168&form=6&db=m Beta-amyloid peptide binding protein does not couple to G protein in a heterologous Xenopus expression system. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839835&form=6&db=m Some sweet and bitter tastants stimulate inhibitory pathway of adenylyl cyclase via melatonin and alpha 2-adrenergic receptors in Xenopus laevis melanophores. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839981&form=6&db=m The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12842760&form=6&db=m Involvement of G(i) proteins and Src tyrosine kinase in TNFalpha production induced by lipopolysaccharide, group B Streptococci and Staphylococcus aureus. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12842891&form=6&db=m Morphine negatively regulates interferon-gamma promoter activity in activated murine T cells through two distinct cyclic AMP-dependent pathways. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12844349&form=6&db=m Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12847111&form=6&db=m Modulation of pro-inflammatory gene expression by nuclear lysophosphatidic acid receptor type-1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12850365&form=6&db=m Pertussis: an important target for maternal immunization. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12852842&form=6&db=m Effects and mechanisms of melatonin on immune responses in mice of different months. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12853397&form=6&db=m T-cell immune response assessment as a complement to serology and intranasal protection assays in determining the protective immunity induced by acellular pertussis vaccines in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12855582&form=6&db=m Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12861851&form=6&db=m Matrix metalloproteinase-9 release from human leukocytes. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12865341&form=6&db=m Testosterone stimulates intracellular calcium release and mitogen-activated protein kinases via a G protein-coupled receptor in skeletal muscle cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12869590&form=6&db=m Melatonin receptor signaling in pregnant and nonpregnant rat uterine myocytes as probed by large conductance Ca2+-activated K+ channel activity. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12869629&form=6&db=m Prostacylin receptor activation inhibits proliferation of aortic smooth muscle cells by regulating cAMP response element-binding protein- and pocket protein-dependent cyclin a gene expression. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12869650&form=6&db=m Requirement of Gbetagamma and c-Src in D2 dopamine receptor-mediated nuclear factor-kappaB activation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12878040&form=6&db=m Involvement of the extracellular signal regulated kinase pathway in hydrocarbon-induced reactive oxygen species formation in human neutrophil granulocytes. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12881481&form=6&db=m Angiotensin II type 2 receptor inhibits vascular endothelial growth factor-induced migration and in vitro tube formation of human endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12882914&form=6&db=m Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883412&form=6&db=m G-protein activation decreases isoflurane inhibition of N-type Ba2+ currents. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883997&form=6&db=m ATP-evoked increase in intracellular calcium via the P2Y receptor in proliferating bovine trophoblast cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12884281&form=6&db=m Lysophosphatidic acid induces human natural killer cell chemotaxis and intracellular calcium mobilization. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12888188&form=6&db=m Effects of spinally and supraspinally injected 3-isobutyl-1-methylxanthine, cholera toxin, and pertussis toxin on immobilization stress-induced antinociception in the mouse. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12890682&form=6&db=m Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12890700&form=6&db=m Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12890786&form=6&db=m DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12890891&form=6&db=m A novel action of palmitoyl-L-carnitine in human vascular endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12890892&form=6&db=m Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12892827&form=6&db=m The beta6/alpha5 regions of Galphai2 and GalphaoA increase the promiscuity of Galpha16 but are insufficient for pertussis toxin-catalyzed ADP-ribosylation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12893538&form=6&db=m Pharmacological analysis of the contractile role of M2 and M3 muscarinic receptors in smooth muscle. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12895426&form=6&db=m Noncanonical signaling by ionotropic kainate receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12899695&form=6&db=m Glucose sensing in the intestinal epithelium. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12899713&form=6&db=m CXCR4 chemokine receptors (CD184) and alpha4beta1 integrins mediate spontaneous migration of human CD34+ progenitors and acute myeloid leukaemia cells beneath marrow stromal cells (pseudoemperipolesis). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902325&form=6&db=m Anti-migratory and anti-invasive effect of somatostatin in human neuroblastoma cells: involvement of Rac and MAP kinase activity. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12903471&form=6&db=m [Mechanisms of opioid receptor-induced elevation in intracellular calcium by confocal laser scanning microscopy] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12904379&form=6&db=m Comparison of the Bordetella pertussis and Bordetella parapertussis isolates circulating in Saint Petersburg between 1998 and 2000 with Russian vaccine strains. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12911336&form=6&db=m The use of microcalorimetry to characterize tetanus neurotoxin, pertussis toxin and filamentous haemagglutinin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12915235&form=6&db=m Reduced G(i) and G(o) protein function in the rat nucleus accumbens attenuates sensorimotor gating deficits. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12916739&form=6&db=m Biphasic modulation of voltage-dependent currents of retinal cones by cannabinoid CB1 receptor agonist WIN 55212-2. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12921856&form=6&db=m Thromboxane prostanoid receptor in human airway smooth muscle cells: a relevant role in proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12921861&form=6&db=m Arachidonylcyclopropylamide increases microglial cell migration through cannabinoid CB2 and abnormal-cannabidiol-sensitive receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12922081&form=6&db=m Low levels of antipertussis antibodies plus lack of history of pertussis correlate with susceptibility after household exposure to Bordetella pertussis. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12924949&form=6&db=m An amyloid-like C-terminal domain of thrombospondin-1 displays CD47 agonist activity requiring both VVM motifs. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12925096&form=6&db=m Determination of pertactin IgG antibodies for the diagnosis of pertussis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12925212&form=6&db=m The proteinase-activated receptor-2 mediates phagocytosis in a Rho-dependent manner in human keratinocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12926327&form=6&db=m [Genetic variability of Bordetella pertussis strains. Part I. Current knowledge] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12926328&form=6&db=m [Genetic variability of Bordetella pertussis strains. Part II. Perspectives] causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12928376&form=6&db=m Dissociating the enhancing and inhibitory effects of pertussis toxin on autoimmune disease. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12929130&form=6&db=m Characterization of the toxic mechanism triggered by Alzheimer's amyloid-beta peptides via p75 neurotrophin receptor in neuronal hybrid cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12937167&form=6&db=m Functional annotation of the putative orphan Caenorhabditis elegans G-protein-coupled receptor C10C6.2 as a FLP15 peptide receptor. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12940889&form=6&db=m Combined pharmacological preconditioning with a G-protein-coupled receptor agonist, a mitochondrial KATP channel opener and a nitric oxide donor mimics ischaemic preconditioning. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941430&form=6&db=m The human formyl peptide receptor as model system for constitutively active G-protein-coupled receptors. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12943808&form=6&db=m Sphingosine-1-phosphate stimulates smooth muscle cell migration through galpha(i)- and pi3-kinase-dependent p38(MAPK) activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12945229&form=6&db=m [Impairment of atypical beta-adrenergic-mediated relaxation in spontaneously hypertensive rats before and during the development of arterial hypertension] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12946329&form=6&db=m Role of nuclear factor-kappa B in the regulation of intercellular adhesion molecule 1 after infection of human bronchial epithelial cells by Bordetella pertussis. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12949228&form=6&db=m GABA mediates autoreceptor feedback inhibition in the rat carotid body via presynaptic GABAB receptors and TASK-1. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12949933&form=6&db=m Adrenergic regulation of the intracellular [Ca2+] and voltage-operated Ca2+ channel currents in the rat prostate neuroendocrine cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12950721&form=6&db=m Ca(2+)-inactivated K+ current is modulated by endothelin-1 in B-16 murine melanoma cells. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12951641&form=6&db=m C-peptide makes a comeback. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12952924&form=6&db=m A role for surface lymphotoxin in experimental autoimmune encephalomyelitis independent of LIGHT. causal interaction,ongoing research,therapeutic application,unassigned 1,1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12952947&form=6&db=m G protein-coupled endothelial receptor for atypical cannabinoid ligands modulates a Ca2+-dependent K+ current. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12954603&form=6&db=m The Ca2+-sensing receptor couples to Galpha12/13 to activate phospholipase D in Madin-Darby canine kidney cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12954648&form=6&db=m Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12956724&form=6&db=m Distinct receptors and different transduction mechanisms for ATP and adenosine at the frog motor nerve endings. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12965249&form=6&db=m Comparing the pathogenesis of experimental autoimmune encephalomyelitis in CD4-/- and CD8-/- DBA/1 mice defines qualitative roles of different T cell subsets. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12969973&form=6&db=m Novel role of the membrane-bound chemokine fractalkine in platelet activation and adhesion. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12970392&form=6&db=m Neuropeptide Y receptor-mediated sensitization of ATP-stimulated inositol phosphate formation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12972295&form=6&db=m Coupling to Gs and G(q/11) of histamine H2 receptors heterologously expressed in adult rat atrial myocytes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12972327&form=6&db=m Agonist function of the neurokinin receptor antagonist, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, in monocytes. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12972572&form=6&db=m The GTP-binding protein RhoA mediates Na,K-ATPase exocytosis in alveolar epithelial cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12975249&form=6&db=m Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13679572&form=6&db=m Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13680090&form=6&db=m The imidazoline NNC77-0020 affects glucose-dependent insulin, glucagon and somatostatin secretion in mouse pancreatic islets. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13755302&form=6&db=m [Studies of the reaction of the living body to pertussis vaccine, with special reference to electromyographic experiments with the intercostal muscles. II. Electromyogram of the intercostal muscles by inoculation with Hemophilus pertussis type I and Hemophilus pertussis toxin after Hemophilus pertussis vaccination.] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13860868&form=6&db=m [Studies on the toxins of Bordetella pertussis. 7. Investigation by sedimentation analysis of some methods of detoxication of pertussis toxin.] ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13861571&form=6&db=m [Effect of pertussis toxin on cells cultivated in vitro.] ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14060999&form=6&db=m STUDIES ON PERTUSSIS TOXIN. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14238941&form=6&db=m THE NEUTRALIZATION OF B. PERTUSSIS TOXIN IN A TISSUE CULTURE. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14460789&form=6&db=m [Studies on the toxins of Bordetella pertussis. 8. Pathohistologic studies on all organs of mice inoculated with pertussis toxin.] ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14500742&form=6&db=m A presynaptic action of the neurosteroid pregnenolone sulfate on GABAergic synaptic transmission. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14507352&form=6&db=m Signalling mechanism coupled to 5-hydroxytryptamine4 receptor-mediated facilitation of fast synaptic transmission in the guinea-pig ileum myenteric plexus. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14511654&form=6&db=m High density lipoprotein-associated lysosphingolipids reduce E-selectin expression in human endothelial cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14514723&form=6&db=m Adenosine induces vasoconstriction through Gi-dependent activation of phospholipase C in isolated perfused afferent arterioles of mice. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14517212&form=6&db=m A predominant role for inhibition of the adenylate cyclase/protein kinase A pathway in ERK activation by cannabinoid receptor 1 in N1E-115 neuroblastoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14518564&form=6&db=m Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14519448&form=6&db=m Direct and biochemical interaction between dopamine D3 receptor and elongation factor-1Bbetagamma. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14521590&form=6&db=m Thrombin induces neoangiogenesis in the chick chorioallantoic membrane. causal interaction,ongoing research,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14521627&form=6&db=m Melatonin prevents apoptosis and enhances HSP27 mRNA expression induced by heat shock in HL-60 cells: possible involvement of the MT2 receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14522843&form=6&db=m Tetrahydrocannabinol-induced neurotoxicity depends on CB1 receptor-mediated c-Jun N-terminal kinase activation in cultured cortical neurons. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14523027&form=6&db=m Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14527175&form=6&db=m Differential activation of signal transduction pathways mediating oxidative burst by chicken heterophils in response to stimulation with lipopolysaccharide and lipoteichoic acid. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14530216&form=6&db=m Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14530218&form=6&db=m Identification and characterisation of GPR100 as a novel human G-protein-coupled bradykinin receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14532091&form=6&db=m Identification of peptides that mimic the pertussis toxin binding site on bovine fetuin. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14555292&form=6&db=m Pharmacological analysis of signal transduction pathways required for oxidative burst in chicken heterophils stimulated by a Toll-like receptor 2 agonist. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14555721&form=6&db=m Activation of M1 muscarinic receptors triggers transmitter release from rat sympathetic neurons through an inhibition of M-type K+ channels. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14555820&form=6&db=m Production of stromal cell-derived factor-1 (SDF-1)and expression of CXCR4 in human bone marrow endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14556974&form=6&db=m Human chymase stimulates Ca2+ signaling in human polymorphonuclear cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14561589&form=6&db=m Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblasts. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14561865&form=6&db=m Biphasic effects of cannabinoids on acetylcholine release in the hippocampus: site and mechanism of action. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14563173&form=6&db=m G-protein modulators alter the swimming behavior and calcium influx of Paramecium tetraurelia. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14563692&form=6&db=m Complement C3a receptors in the pituitary gland: a novel pathway by which an innate immune molecule releases hormones involved in the control of inflammation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566001&form=6&db=m Hyperosmolar solution effects in guinea pig airways. III. Studies on the identity of epithelium-derived relaxing factor in isolated perfused trachea using pharmacological agents. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566008&form=6&db=m Sensitization of neuronal A2A adenosine receptors after persistent D2 dopamine receptor activation. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14567755&form=6&db=m Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14568343&form=6&db=m Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14572803&form=6&db=m Formyl-Met-Leu-Phe induces calcium-dependent tyrosine phosphorylation of Rel-1 in neutrophils. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14573656&form=6&db=m Pertussis toxin plays an early role in respiratory tract colonization by Bordetella pertussis. causal interaction,ongoing research,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14573753&form=6&db=m The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14573761&form=6&db=m beta2-Adrenergic signaling in human heart: shift from the cyclic AMP to the arachidonic acid pathway. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14573770&form=6&db=m Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14575775&form=6&db=m DNA vaccine encoding pertussis toxin S1 subunit induces protection against Bordetella pertussis in mice. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14575866&form=6&db=m Sensitization of adenylate cyclase by short-term activation of 5-HT1A receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14575876&form=6&db=m N-acetylaspartylglutamate and beta-NAAG protect against injury induced by NMDA and hypoxia in primary spinal cord cultures. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14576057&form=6&db=m Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14576516&form=6&db=m Age increases expression and receptor-mediated activation of G alpha i in human atria. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14576545&form=6&db=m Lidocaine enhances Galphai protein function. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14576941&form=6&db=m Masked excitatory action of noradrenaline on rat islet beta-cells via activation of phospholipase C. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14578115&form=6&db=m Impaired substance P release from renal sensory nerves in SHR involves a pertussis toxin-sensitive mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14580235&form=6&db=m Ras activation in response to lysophosphatidic acid requires a permissive input from the epidermal growth factor receptor. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14581400&form=6&db=m Smooth muscle cells in human atherosclerotic plaques express the fractalkine receptor CX3CR1 and undergo chemotaxis to the CX3C chemokine fractalkine (CX3CL1). ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14581469&form=6&db=m A region of the third intracellular loop of the short form of the D2 dopamine receptor dictates Gi coupling specificity. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14583135&form=6&db=m CNP-induced changes in pHi, cGMP/cAMP and mRNA expression of natriuretic peptide receptors in human trabecular meshwork cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14592418&form=6&db=m Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14594552&form=6&db=m Attenuation of changes in G(i)-proteins and adenylyl cyclase in heart failure by an ACE inhibitor, imidapril. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14596794&form=6&db=m Lysophosphatidylcholine regulates human microvascular endothelial cell expression of chemokines. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14596931&form=6&db=m Pertussis toxin-sensitive Galphai protein and ERK-dependent pathways mediate ultrasound promotion of osteogenic transcription in human osteoblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14602719&form=6&db=m Signaling cross-talk from Gbeta4 subunit to Elk-1 in the rapid action of androgens. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14603250&form=6&db=m Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14603464&form=6&db=m Manipulation of olfactory ensheathing cell signaling mechanisms: effects on their support for neurite regrowth from adult CNS neurons in coculture. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14604578&form=6&db=m European Sero-Epidemiology Network: standardisation of the assay results for pertussis. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14607279&form=6&db=m Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14607283&form=6&db=m Nerve growth factor signaling involves interaction between the Trk A receptor and lysophosphatidate receptor 1 systems: nuclear translocation of the lysophosphatidate receptor 1 and Trk A receptors in pheochromocytoma 12 cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14607408&form=6&db=m The new strategy for allele identification of the genes coding for pertussis toxin subunit S1 (ptx S1) and pertactin (prn) in Bordetella pertussis. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14607959&form=6&db=m CiC3-1a-mediated chemotaxis in the deuterostome invertebrate Ciona intestinalis (Urochordata). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14607966&form=6&db=m Unopposed matrix metalloproteinase-9 expression in human tuberculous granuloma and the role of TNF-alpha-dependent monocyte networks. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14608042&form=6&db=m Sphingosine-1-phosphate inhibition of apoptosis requires mitogen-activated protein kinase phosphatase-1 in mouse fibroblast C3H10T 1/2 cells. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14609552&form=6&db=m Delta-opioid agonist-stimulated inositol phosphate formation in isolated, rabbit iris-ciliary bodies: role of G(i/o) proteins and Gbetagamma-subunits. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14612574&form=6&db=m Cardioprotection specific for the G protein Gi2 in chronic adrenergic signaling through beta 2-adrenoceptors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14613890&form=6&db=m Molecular mechanism of nucleotide-induced primary granule release in human neutrophils: role for the P2Y2 receptor. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14613926&form=6&db=m Epinephrine-induced hyperpolarization of islet cells without KATP channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14614308&form=6&db=m Experimental autoimmune encephalomyelitis in cynomolgus monkeys. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14615280&form=6&db=m Heterotrimeric G protein Gi is involved in a signal transduction pathway for ATP release from erythrocytes. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14615286&form=6&db=m Signaling mechanisms that mediate nitric oxide production induced by acetylcholine exposure and withdrawal in cat atrial myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14617682&form=6&db=m Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14622107&form=6&db=m Cyclic phosphatidic acid elicits neurotrophin-like actions in embryonic hippocampal neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14622172&form=6&db=m Contribution of Kir3.1, Kir3.2A and Kir3.2C subunits to native G protein-gated inwardly rectifying potassium currents in cultured hippocampal neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623768&form=6&db=m ET-1-associated vasomotion and vasospasm in lymphatic vessels of the guinea-pig mesentery. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14625285&form=6&db=m CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14627441&form=6&db=m Identification of a potent serum factor that causes desensitization of the receptor for C-Type natriuretic peptide. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14634050&form=6&db=m D2 dopamine receptors modulate Galpha-subunit coupling of the CB1 cannabinoid receptor. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14634054&form=6&db=m Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14644161&form=6&db=m Swimming behavior regulation by GABAB receptors in Paramecium. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14644424&form=6&db=m Role of secretory and cytosolic phospholipase A(2) enzymes in lysophosphatidylcholine-stimulated monocyte arachidonic acid release. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14645666&form=6&db=m Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14646356&form=6&db=m Pertussis toxin-sensitive G protein but not NO/cGMP pathway mediates the negative inotropic effect of carbachol in adult rat cardiomyocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14648542&form=6&db=m Characterization of lysophosphatidic acid and sphingosine-1-phosphate-mediated signal transduction in rat cortical oligodendrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14648557&form=6&db=m PLA2 and secondary metabolites of arachidonic acid control filopodial behavior in neuronal growth cones. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14651255&form=6&db=m Degranulation and cytokine expression in human cord blood-derived mast cells cultured in serum-free medium with recombinant human stem cell factor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14651259&form=6&db=m Signaling via histamine receptors in cat duodenal smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14652000&form=6&db=m TIMP-1 inhibits apoptosis in breast carcinoma cells via a pathway involving pertussis toxin-sensitive G protein and c-Src. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14656287&form=6&db=m 5-HT inhibits N-type but not L-type Ca(2+) channels via 5-HT1A receptors in lamprey spinal neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14656772&form=6&db=m Interleukin-6 and interleukin-15 are selectively regulated by lipopolysaccharide and interferon-gamma in primary pig adipocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14660553&form=6&db=m Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14660630&form=6&db=m Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14662730&form=6&db=m A truncated form of CKbeta8-1 is a potent agonist for human formyl peptide-receptor-like 1 receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14662731&form=6&db=m Adenine nucleotides inhibit recombinant N-type calcium channels via G protein-coupled mechanisms in HEK 293 cells; involvement of the P2Y13 receptor-type. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14664705&form=6&db=m The effects of GH-releasing hormone/somatostatin on the 5'-promoter activity of the GH gene in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14667935&form=6&db=m Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via phosphatidylinositol-3'-kinase. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14668348&form=6&db=m 11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14669971&form=6&db=m Lack of stereospecificity in lysophosphatidic acid enantiomer-induced calcium mobilization in human erythroleukemia cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14670995&form=6&db=m Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2beta by the CRF/urocortin family of peptides. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14672352&form=6&db=m Shock wave application enhances pertussis toxin protein-sensitive bone formation of segmental femoral defect in rats. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14672813&form=6&db=m Dopamine-induced synaptic depression in the parabrachial nucleus is independent of CTX- and PTX-sensitive G-proteins, PKA and PLC signalling pathways. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14679223&form=6&db=m Temporal expression of pertussis toxin and Ptl secretion proteins by Bordetella pertussis. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14680004&form=6&db=m Regulation of cyclic adenosine 3',5'- monophosphate signaling and pulsatile neurosecretion by Gi-coupled plasma membrane estrogen receptors in immortalized gonadotrophin-releasing hormone neurons. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14684377&form=6&db=m SDF-1/CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14685704&form=6&db=m Delayed cardioprotection is mediated via a non-peptide delta opioid agonist, SNC-121, independent of opioid receptor stimulation. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14687713&form=6&db=m Involvement of MAP kinase signal transduction pathway in UVB-induced activation of macrophages in vitro. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14688147&form=6&db=m Antibody-mediated neutralization of pertussis toxin-induced mitogenicity of human peripheral blood mononuclear cells. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14688202&form=6&db=m Protein kinase C regulates functional coupling of beta1-adrenergic receptors to Gi/o-mediated responses in cardiac myocytes. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14688343&form=6&db=m A functional C5a anaphylatoxin receptor in a teleost species. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14691048&form=6&db=m Platelet-activating factor increases pH(i) in bovine neutrophils through the PI3K-ERK1/2 pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14691050&form=6&db=m Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14691297&form=6&db=m Induction of intercellular adhesion molecule-1 on human brain endothelial cells by HIV-1 gp120: role of CD4 and chemokine coreceptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14692828&form=6&db=m Characterization of human melanoma cell lines according to their migratory properties in vitro. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14695118&form=6&db=m Pertussis toxin activates L-arginine uptake in pulmonary endothelial cells through downregulation of PKC-alpha activity. causal interaction,ongoing research,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14695200&form=6&db=m Activation of p21-activated kinase 1-nuclear factor kappaB signaling by Kaposi's sarcoma-associated herpes virus G protein-coupled receptor during cellular transformation. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14699136&form=6&db=m A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14701866&form=6&db=m Calcium-sensing receptor-mediated ERK1/2 activation requires Galphai2 coupling and dynamin-independent receptor internalization. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14702348&form=6&db=m Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14704229&form=6&db=m Inflammation- and ischemia-induced shedding of venular glycocalyx. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14706780&form=6&db=m Lysophosphatidic acid stimulates calcium transients in enteric glia. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14707029&form=6&db=m Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14707040&form=6&db=m C-peptide colocalizes with macrophages in early arteriosclerotic lesions of diabetic subjects and induces monocyte chemotaxis in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14707114&form=6&db=m Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14711826&form=6&db=m Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14711858&form=6&db=m Acellular pertussis vaccine given by accelerated schedule: response of preterm infants. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14712229&form=6&db=m G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14718601&form=6&db=m Metabotropic signal transduction for bradykinin in submucosal neurons of guinea pig small intestine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14718842&form=6&db=m Domain-dependent action of urokinase on smooth muscle cell responses. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14722328&form=6&db=m Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14723877&form=6&db=m Characterization of melatonin binding sites in the brain and retina of the frog Rana perezi. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14726441&form=6&db=m An Intrinsic gamma-aminobutyric acid (GABA)ergic system in the adrenal cortex: findings from human and rat adrenal glands and the NCI-H295R cell line. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14729379&form=6&db=m Celecoxib simulates respiratory burst through pertussis toxin-sensitive G-protein, a possible signal for beta 2-integrin expression on human neutrophils. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14730131&form=6&db=m Neurite outgrowth-stimulating activities of beta-casomorphins in Neuro-2a mouse neuroblastoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14734046&form=6&db=m Loss of beta-adrenoceptor response in myocytes overexpressing the Na+/Ca(2+)-exchanger. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14741403&form=6&db=m The involvement of VEGF receptors and MAPK in the cannabinoid potentiation of Ca2+ flux into N18TG2 neuroblastoma cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14741707&form=6&db=m Existence of GPR40 functioning in a human breast cancer cell line, MCF-7. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14741774&form=6&db=m Reversal of ongoing thermal hyperalgesia in mice by a recombinant herpesvirus that encodes human preproenkephalin. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14741844&form=6&db=m Endothelial NADPH oxidase: mechanism of activation by low-density lipoprotein. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14742268&form=6&db=m CXCR3 is involved in tubulointerstitial injury in human glomerulonephritis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14742736&form=6&db=m Pharmacological and signaling properties of endogenous P2Y1 receptors in cystic fibrosis transmembrane conductance regulator-expressing Chinese hamster ovary cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14744631&form=6&db=m Low-affinity receptor-mediated induction of superoxide by N-formyl-methionyl-leucyl-phenylalanine and WKYMVm in IMR90 human fibroblasts. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14745117&form=6&db=m The action mode of lysophosphatidylcholine in human monocytes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14746826&form=6&db=m Mechanisms of diethylstilbestrol-induced relaxation in rat aorta smooth muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14751238&form=6&db=m Insulin-like growth factor binding protein-3 stimulates phosphatidylinositol 3-kinase in MCF-7 breast carcinoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14751252&form=6&db=m Magnetic bead isolation of neutrophil plasma membranes and quantification of membrane-associated guanine nucleotide binding proteins. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14751540&form=6&db=m Bradykinin-stimulated p42/p44 MAPK activation associated with cell proliferation in corneal keratocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14751870&form=6&db=m Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14755544&form=6&db=m Recruitment and proliferation of T lymphocytes is supported by IFNgamma- and TNFalpha-activated human osteoblasts: Involvement of CD54 (ICAM-1) and CD106 (VCAM-1) adhesion molecules and CXCR3 chemokine receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14757365&form=6&db=m Lysophosphatidylcholine is a regulator of tyrosine kinase activity and intracellular Ca(2+) level in Jurkat T cell line. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14760501&form=6&db=m Natriuretic peptides inhibit adenylyl cyclase activity in dispersed eel gill cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14760749&form=6&db=m Induction of tryptase and histamine release from human colon mast cells by IgE dependent or independent mechanisms. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14760750&form=6&db=m Modulation of tryptase secretion from human colon mast cells by histamine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14760751&form=6&db=m Activation of human colon mast cells through proteinase activated receptor-2. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14765356&form=6&db=m Serologic response and antibody-titer decay in adults with pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14768058&form=6&db=m Inhibition of intra- and extra-cellular Tat function and HIV expression by pertussis toxin B-oligomer. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14768516&form=6&db=m Implications of intrathecal pertussis toxin animal model on the cellular mechanisms of neuropathic pain syndrome. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14871035&form=6&db=m Role of alpha2-adrenergic receptors and cyclic adenosine monophosphate-dependent protein kinase in the regulation of norepinephrine release in the central nervous system of spontaneously hypertensive rats. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14871834&form=6&db=m CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14975356&form=6&db=m Suramin has adjuvant properties and promotes expansion of antigen-specific Th1 and Th2 cells in vivo. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14975703&form=6&db=m Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14977950&form=6&db=m Bordetella pertussis infection of primary human monocytes alters HLA-DR expression. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14978183&form=6&db=m Activation of Syk in neutrophils by antineutrophil cytoplasm antibodies occurs via Fcgamma receptors and CD18. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14978203&form=6&db=m P2Y purinergic receptor regulation of CFTR chloride channels in mouse cardiac myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14978245&form=6&db=m Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14978744&form=6&db=m Inosine stimulates chemotaxis, Ca2+-transients and actin polymerization in immature human dendritic cells via a pertussis toxin-sensitive mechanism independent of adenosine receptors. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14982725&form=6&db=m Human immunodeficiency virus type 1 Tat and methamphetamine affect the release and activation of matrix-degrading proteinases. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14982842&form=6&db=m Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14982925&form=6&db=m Characterization of Na+-permeable cation channels in LLC-PK1 renal epithelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14990582&form=6&db=m Enhanced adhesive capacities of the naturally occurring Ile249-Met280 variant of the chemokine receptor CX3CR1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14993103&form=6&db=m Differential modulation of ATP-induced calcium signalling by A1 and A2 adenosine receptors in cultured cortical astrocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14996947&form=6&db=m Critical role of L-selectin and histamine H4 receptor in zymosan-induced neutrophil recruitment from the bone marrow: comparison with carrageenan. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14996950&form=6&db=m Novel regulatory properties of human type 9 adenylate cyclase. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14996951&form=6&db=m Dual effects of DAMGO [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin and CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2) on adenylyl cyclase activity: implications for mu-opioid receptor Gs coupling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14999808&form=6&db=m Novel metabotropic glutamate receptor negatively coupled to adenylyl cyclase in cultured rat cerebellar astrocytes. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15003661&form=6&db=m Sero-epidemiology of Bordetella pertussis in England and Wales. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15004729&form=6&db=m Phospholipid metabolism is required for M1 muscarinic inhibition of N-type calcium current in sympathetic neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15008743&form=6&db=m Involvement of signal transducing GTP-binding proteins in renal artery alpha 1-adrenoceptor mediated smooth muscle contraction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15009427&form=6&db=m Human beta-defensin-2 functions as a chemotactic agent for tumour necrosis factor-alpha-treated human neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15014136&form=6&db=m Endogenous regulator of G protein signaling proteins suppress Galphao-dependent, mu-opioid agonist-mediated adenylyl cyclase supersensitization. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15016615&form=6&db=m In vitro activation of murine DRG neurons by CGRP-mediated mucosal mast cell degranulation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15018614&form=6&db=m Ceramide 1-phosphate enhances calcium entry through voltage-operated calcium channels by a protein kinase C-dependent mechanism in GH4C1 rat pituitary cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15019559&form=6&db=m Functional coupling of the nociceptin/orphanin FQ receptor in dog brain membranes. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15020077&form=6&db=m The neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) modulate several biochemical pathways in human leukemic myeloid cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15020218&form=6&db=m Dexras1 inhibits adenylyl cyclase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15020650&form=6&db=m MCP-1-dependent signaling in CCR2(-/-) aortic smooth muscle cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15020696&form=6&db=m Characterization of a hyperpolarization-activated time-dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15023857&form=6&db=m Multiple actions of anandamide on neonatal rat cultured sensory neurones. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15025562&form=6&db=m Ligand-dependent autophosphorylation of the insulin receptor is positively regulated by Gi-proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15031261&form=6&db=m G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15034064&form=6&db=m Lysophosphatidic acid induces chemotaxis, oxygen radical production, CD11b up-regulation, Ca2+ mobilization, and actin reorganization in human eosinophils via pertussis toxin-sensitive G proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15034221&form=6&db=m Multiple signal transduction pathways mediated by 5-HT receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15036623&form=6&db=m Blockade of Gi/o proteins modifies electrical activity of S-myenteric neurons from guinea-pig ileum. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15037513&form=6&db=m Comparison of functional profiles at human recombinant somatostatin sst2 receptor: simultaneous determination of intracellular Ca2+ and luciferase expression in CHO-K1 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15039327&form=6&db=m Analysis of relative levels of production of pertussis toxin subunits and Ptl proteins in Bordetella pertussis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15041474&form=6&db=m CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15041999&form=6&db=m Evidence for tight coupling of Gi protein-mediated lysophosphatidic acid receptor to stimulated cytokine production in ovarian cancer cell. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15044044&form=6&db=m In vivo pertussis toxin treatment reduces contraction of rat resistance arteries but not that of mouse trachea. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15044621&form=6&db=m Atrial natriuretic peptide-C receptor-induced attenuation of adenylyl cyclase signaling activates phosphatidylinositol turnover in A10 vascular smooth muscle cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15047615&form=6&db=m Metabotropic glutamate receptor type 4 is involved in autoinhibitory cascade for glucagon secretion by alpha-cells of islet of Langerhans. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15048016&form=6&db=m Nonselective cation channels activated by the stimulation of muscarinic receptors in mammalian gastric smooth muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15048928&form=6&db=m Stromal cell-derived factor 1-mediated CXCR4 signaling in rat and human cortical neural progenitor cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15051153&form=6&db=m Activation of muscarinic receptors inhibits spinal dorsal horn projection neurons: role of GABAB receptors. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15051158&form=6&db=m Mechanisms underlying the riluzole inhibition of glutamate release from rat cerebral cortex nerve terminals (synaptosomes). ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15056287&form=6&db=m P2Y12 receptor stimulation inhibits beta-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase B. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15060220&form=6&db=m Antibody response to diphtheria-tetanus-pertussis immunization in preterm infants who receive dexamethasone for chronic lung disease. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15061492&form=6&db=m Temporal trends in circulating Bordetella pertussis strains in Australia. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15063151&form=6&db=m Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15063583&form=6&db=m Rapid purification of pertussis toxin (PT) and filamentous hemagglutinin (FHA) by cation-exchange chromatography. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15064239&form=6&db=m Lipoteichoic acid-stimulated p42/p44 MAPK activation via Toll-like receptor 2 in tracheal smooth muscle cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15066141&form=6&db=m PACAP inhibits delayed rectifier potassium current via a cAMP/PKA transduction pathway: evidence for the involvement of I k in the anti-apoptotic action of PACAP. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15066149&form=6&db=m Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15066181&form=6&db=m Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15067015&form=6&db=m Conjugated linoleic acid induces human adipocyte delipidation: autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15069188&form=6&db=m Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15070661&form=6&db=m Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15070679&form=6&db=m Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15070904&form=6&db=m kappa Opioid receptor interacts with Na(+)/H(+)-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na(+)/H(+) exchange independent of G(i)/G(o) proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15071014&form=6&db=m Simple Algorithm for Identification of Bordetella pertussis Pertactin Gene Variants. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15072850&form=6&db=m In vitro activation of murine peritoneal macrophages by ultraviolet B radiation: upregulation of CD18, production of NO, proinflammatory cytokines and a signal transduction pathway. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075212&form=6&db=m Distinctive G protein-dependent signaling in smooth muscle by sphingosine 1-phosphate receptors S1P1 and S1P2. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15081308&form=6&db=m Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15084650&form=6&db=m P2X receptor activation elicits transporter-mediated noradrenaline release from rat hippocampal slices. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15087236&form=6&db=m Receptors for bitter, sweet and umami taste couple to inhibitory G protein signaling pathways. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15093616&form=6&db=m Role of an aprotinin-sensitive protease in protein kinase Calpha-mediated activation of cytosolic phospholipase A2 by calcium ionophore (A23187) in pulmonary endothelium. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15093686&form=6&db=m Human angiotensin II type-2 receptor inhibition of insulin-mediated ERK-2 activity via a G-protein coupled signaling pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15094059&form=6&db=m G protein-activated K+ channels: a reporter for rapid activation of G proteins by lysophosphatidic acid in Xenopus oocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15095366&form=6&db=m The antiapoptotic effect of guanosine is mediated by the activation of the PI 3-kinase/AKT/PKB pathway in cultured rat astrocytes. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15096537&form=6&db=m CXCL12 mediates CCR7-independent homing of central memory cells, but not naive T cells, in peripheral lymph nodes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15096543&form=6&db=m Sequence variation and conservation in virulence-related genes of Bordetella pertussis isolates from the UK. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15099699&form=6&db=m Receptor mechanisms mediating cyanide generation in PC12 cells and rat brain. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15102938&form=6&db=m Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15102960&form=6&db=m Epinephrine activates both Gs and Gi pathways, but norepinephrine activates only the Gs pathway through human beta2-adrenoceptors overexpressed in mouse heart. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15103688&form=6&db=m Sero epidemiology of Bordetella pertussis immune responses in a healthy population in northern Greece. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15107293&form=6&db=m Mechanism of cicaprost-induced desensitization in rat pulmonary artery smooth muscle cells involves a PKA-mediated inhibition of adenylyl cyclase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15107593&form=6&db=m Regulation of mitogen-activated protein kinase cascades by low density lipoprotein and lysophosphatidic acid. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15110769&form=6&db=m Targets for TNF-alpha-induced lipolysis in human adipocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15113900&form=6&db=m Migration of antigen-specific T cells away from CXCR4-binding human immunodeficiency virus type 1 gp120. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15118214&form=6&db=m Seroepidemiologic study on pertussis, diphtheria, and tetanus in the Fukuoka area of southern Japan: seroprevalence among persons 0-80 years old and vaccination program. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15123672&form=6&db=m Gbetagamma-activated inwardly rectifying K(+) (GIRK) channel activation kinetics via Galphai and Galphao-coupled receptors are determined by Galpha-specific interdomain interactions that affect GDP release rates. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15124761&form=6&db=m Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15125661&form=6&db=m Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15126921&form=6&db=m Abnormal regulation of G protein alpha(i2) subunit in skin fibroblasts from insulin-resistant hypertensive individuals. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15136060&form=6&db=m Simvastatin potenciates PGI(2) release induced by HDL in human VSMC: effect on Cox-2 up-regulation and MAPK signalling pathways activated by HDL. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15137065&form=6&db=m Response to lysophosphatidic acid in Xenopus oocytes and its rapid desensitization: the role of Gq and Go G-protein families. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15137583&form=6&db=m Inhibitory interaction of cannabinoid CB1 receptor and dopamine D2 receptor agonists on voltage-gated currents of goldfish cones. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15140874&form=6&db=m The M3 receptor-mediated K(+) current (IKM3), a G(q) protein-coupled K(+) channel. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15145074&form=6&db=m Expression of protease-activated receptors (PARs) in OLN-93 oligodendroglial cells and mechanism of PAR-1-induced calcium signaling. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15145516&form=6&db=m Differential inhibition of fatty acid transport in tissue-isolated steroid receptor negative human breast cancer xenografts perfused in situ with isomers of conjugated linoleic acid. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15145758&form=6&db=m Cadmium inhibits GABA-activated ion currents by increasing intracellular calcium level in snail neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15145975&form=6&db=m Phosphatidylinositol transfer protein alpha regulates growth and apoptosis of NIH3T3 cells: involvement of a cannabinoid 1-like receptor. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15148262&form=6&db=m Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission in the rat isolated mesenteric arterial bed via a non-CB1/CB2 G(i/o) linked receptor. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15149035&form=6&db=m Bordetella pertussis from functional genomics to intranasal vaccination. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15149768&form=6&db=m Sequence variation in pertussis S1 subunit toxin and pertussis genes in Bordetella pertussis strains used for the whole-cell pertussis vaccine produced in Poland since 1960: efficiency of the DTwP vaccine-induced immunity against currently circulating B. pertussis isolates. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15150332&form=6&db=m Laboratory diagnosis of pertussis infections: the role of PCR and serology. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15151902&form=6&db=m Involvement of G protein betagamma-subunits in diverse signaling induced by G(i/o)-coupled receptors: study using the Xenopus oocyte expression system. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15152027&form=6&db=m Regulation of rat hepatocyte function by P2Y receptors: focus on control of glycogen phosphorylase and cyclic AMP by 2-methylthioadenosine 5'-diphosphate. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15153516&form=6&db=m C3a enhances nerve growth factor-induced NFAT activation and chemokine production in a human mast cell line, HMC-1. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15154669&form=6&db=m 5-Hydroxytryptamine 1B receptors mediate presynaptic inhibition of monosynaptic IPSC in the rat dorsolateral septal nucleus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15155564&form=6&db=m Reoxygenation after severe hypoxia induces cardiomyocyte hypertrophy in vitro: activation of CREB downstream of GSK3beta. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15155640&form=6&db=m Suppression of serum antibody responses by pertussis toxin after respiratory tract colonization by Bordetella pertussis and identification of an immunodominant lipoprotein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15157285&form=6&db=m Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15159403&form=6&db=m Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15159548&form=6&db=m Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15160555&form=6&db=m [Health Council of the Netherlands advisory report 'Vaccination against pertussis'--time for a new vaccine] diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15163697&form=6&db=m Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15164168&form=6&db=m Potent activation of multiple signalling pathways by C-peptide in opossum kidney proximal tubular cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15165669&form=6&db=m An evaluation of serious neurological disorders following immunization: a comparison of whole-cell pertussis and acellular pertussis vaccines. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15166482&form=6&db=m Dual signaling and effector pathways mediate human eosinophil activation by platelet-activating factor. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15167983&form=6&db=m ATP priming of macrophage-derived chemokine responses in CHO cells expressing the CCR4 receptor. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15172963&form=6&db=m Epidermal growth factor differentially augments G(i)-mediated stimulation of c-Jun N-terminal kinase activity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15175025&form=6&db=m Signaling events during induction of plasminogen activator inhibitor-1 expression by sphingosylphosphorylcholine in cultured human dermal fibroblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15180992&form=6&db=m Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15183123&form=6&db=m Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptor. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15183694&form=6&db=m Dehydroepiandrosterone stimulates nitric oxide release in vascular endothelial cells: evidence for a cell surface receptor. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15189775&form=6&db=m Pertussis toxin-induced histamine sensitisation: an aspecific phenomenon independent from the nitric oxide system? diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15191917&form=6&db=m Src kinase mediates angiotensin II-dependent increase in pulmonary endothelial nitric oxide synthase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15192102&form=6&db=m Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15194005&form=6&db=m Stimulation of early gene induction and cell proliferation by lysophosphatidic acid in human amnion-derived WISH cells: role of phospholipase D-mediated pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15194436&form=6&db=m Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 are involved in both excitotoxin-induced neurodegeneration and regeneration. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15194451&form=6&db=m Cannabinoid agonists induce contractile responses through Gi/o-dependent activation of phospholipase C in the bovine ciliary muscle. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15194868&form=6&db=m Regulation of STAT3 by mu-opioid receptors in human neuroblastoma SH-SY5Y cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15196671&form=6&db=m Histamine H3 receptor activation inhibits dopamine D1 receptor-induced cAMP accumulation in rat striatal slices. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15197738&form=6&db=m Characterization of V642I-AbetaPP-induced cytotoxicity in primary neurons. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15201703&form=6&db=m Toll-like receptor 4 coupled GI protein signaling pathways regulate extracellular signal-regulated kinase phosphorylation and AP-1 activation independent of NFkappaB activation. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15205333&form=6&db=m Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15207317&form=6&db=m M2 muscarinic receptors in pontine reticular formation of C57BL/6J mouse contribute to rapid eye movement sleep generation. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15207363&form=6&db=m Alpha-2 agonists induce amnesia through activation of the Gi-protein signalling pathway. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15210763&form=6&db=m The third signal in T cell-mediated autoimmune disease? therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15212760&form=6&db=m Lysophospholipids and chemokines activate distinct signal transduction pathways in T helper 1 and T helper 2 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15212962&form=6&db=m Cloning and pharmacological characterisation of the guinea pig 5-ht5A receptor. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15213178&form=6&db=m Expression of a C terminally truncated form of pertussis toxin S1 subunit effectively induces protection against pertussis toxin following DNA-based immunization. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15216470&form=6&db=m Prevalence of pertussis antibodies in maternal delivery, cord, and infant serum. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15217839&form=6&db=m PTX-sensitive signals in bone marrow homing of fetal and adult hematopoietic progenitor cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15226304&form=6&db=m Real-time analysis of very late antigen-4 affinity modulation by shear. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15231488&form=6&db=m Nucleotide-mediated mucin secretion from differentiated human bronchial epithelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15231724&form=6&db=m The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15231967&form=6&db=m A controlled study of the relationship between Bordetella pertussis infections and sudden unexpected deaths among German infants. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15231980&form=6&db=m Azithromycin is as effective as and better tolerated than erythromycin estolate for the treatment of pertussis. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15235087&form=6&db=m GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15236747&form=6&db=m Regulation of experimental autoimmune encephalomyelitis by CD4+, CD25+ and CD8+ T cells: analysis using depleting antibodies. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15240669&form=6&db=m IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15240747&form=6&db=m Involvement of multiple P2Y receptors and signaling pathways in the action of adenine nucleotides diphosphates on human monocyte-derived dendritic cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15242419&form=6&db=m The antibodies against Bordetella pertussis in sera of patients with Parkinson's disease and other non-neurological diseases. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15242760&form=6&db=m Prosaposin: a new player in cell death prevention of U937 monocytic cells. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15243929&form=6&db=m Immune responses and antibody decay after immunization of adolescents and adults with an acellular pertussis vaccine: the APERT Study. diagnostic usage,ongoing research,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15245434&form=6&db=m Human leukocyte elastase induces keratinocyte proliferation by epidermal growth factor receptor activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15251437&form=6&db=m Angiogenic activity of human CC chemokine CCL15 in vitro and in vivo. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252011&form=6&db=m Regulation of the coupling to different G proteins of rat corticotropin-releasing factor receptor type 1 in human embryonic kidney 293 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252286&form=6&db=m Dose-dependent activation of Ca2+-activated K+ channels by ethanol contributes to improved endothelial cell functions. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15254969&form=6&db=m High glucose inhibits fructose uptake in renal proximal tubule cells: involvement of cAMP, PLC/PKC, p44/42 MAPK, and cPLA2. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15256866&form=6&db=m IgE-Independent Activation of Human Mast Cells Indicates their Role in the Late Phase Reaction of Allergic Inflammation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15264228&form=6&db=m Cytotoxic mechanisms by M239V presenilin 2, a little-analyzed Alzheimer's disease-causative mutant. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15265705&form=6&db=m Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15265766&form=6&db=m Gialpha3 protein-coupled dopamine D3 receptor-mediated inhibition of renal NHE3 activity in SHR proximal tubular cells is a PLC-PKC-mediated event. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15265811&form=6&db=m Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15265930&form=6&db=m Bordetella pertussis lipopolysaccharide resists the bactericidal effects of pulmonary surfactant protein A. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15269229&form=6&db=m Orexin (hypocretin) effects on constitutively active inward rectifier K+ channels in cultured nucleus basalis neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15272018&form=6&db=m Gi2 signaling enhances proliferation of neural progenitor cells in the developing brain. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15272061&form=6&db=m Comparison of culture and PCR for detection of Bordetella pertussis and Bordetella parapertussis under routine laboratory conditions. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15276478&form=6&db=m Atrial natriuretic peptide modulates the hyperpolarization-activated current (If) in human atrial myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15279887&form=6&db=m Interleukin-1 inhibits voltage-dependent P/Q-type Ca2+ channel associated with the inhibition of the rise of intracellular free Ca2+ concentration and catecholamine release in adrenal chromaffin cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15282218&form=6&db=m Clinicopathological study of a myelin oligodendrocyte glycoprotein-induced demyelinating disease in LEW.1AV1 rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15283694&form=6&db=m IGF-I and insulin induce different intracellular calcium signals in skeletal muscle cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15284388&form=6&db=m Conjugated linoleic acid isomers and trans fatty acids inhibit fatty acid transport in hepatoma 7288CTC and inguinal fat pads in Buffalo rats. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15286801&form=6&db=m Central and peripheral actions of somatostatin on the growth hormone-IGF-I axis. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15288572&form=6&db=m Anandamide transport inhibitor AM404 and structurally related compounds inhibit synaptic transmission between rat hippocampal neurons in culture independent of cannabinoid CB1 receptors. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15288774&form=6&db=m Rapid effects of androgens in macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15291751&form=6&db=m Requirement for G proteins in insulin-like growth factor-I-induced growth of prostate cells. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15293276&form=6&db=m PGE2 receptors rescue motor neurons in a model of amyotrophic lateral sclerosis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15294026&form=6&db=m A study comparing the actions of gabapentin and pregabalin on the electrophysiological properties of cultured DRG neurones from neonatal rats. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15294853&form=6&db=m Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15294948&form=6&db=m Initiation of immune responses in brain is promoted by local dendritic cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15299478&form=6&db=m Isomorphous binding of mercury-substituted thiosaccharides to pertussis toxin crystals yields crystallographic phases. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15302686&form=6&db=m Coupling of the human A1 adenosine receptor to different heterotrimeric G proteins: evidence for agonist-specific G protein activation. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15306218&form=6&db=m Cyclic strain-mediated regulation of endothelial matrix metalloproteinase-2 expression and activity. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15306634&form=6&db=m Histamine H3-receptor-induced attenuation of norepinephrine exocytosis: a decreased protein kinase a activity mediates a reduction in intracellular calcium. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15308619&form=6&db=m Participation of G proteins in natriuretic peptide hormone secretion from heart atria. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15308651&form=6&db=m Coexpression of Y1, Y2, and Y4 receptors in smooth muscle coupled to distinct signaling pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15308762&form=6&db=m A novel nonpeptide ligand for formyl peptide receptor-like 1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313015&form=6&db=m Investigation of G protein-initiated, Ca2+-dependent release of ATP from endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313431&form=6&db=m C5a differentially stimulates the ERK1/2 and p38 MAPK phosphorylation through independent signaling pathways to induced chemotactic migration in RAW264.7 macrophages. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313525&form=6&db=m Polymorphisms in the pertussis toxin promoter in Bordetella bronchiseptica veterinary isolates from Argentina. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313565&form=6&db=m Assays for G-protein-coupled receptor signaling using RGS-insensitive Galpha subunits. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313566&form=6&db=m Use of RGS-insensitive Galpha subunits to study endogenous RGS protein action on G-protein modulation of N-type calcium channels in sympathetic neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15316028&form=6&db=m 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces the migration of EoL-1 human eosinophilic leukemia cells and human peripheral blood eosinophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15316030&form=6&db=m Scavenger receptor A mediates H2O2 production and suppression of IL-12 release in murine macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15317908&form=6&db=m Opioids as modulators of cell death and survival--unraveling mechanisms and revealing new indications. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15319282&form=6&db=m Lysophosphatidic acid accelerates the development of human mast cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15322034&form=6&db=m Analysis of subassemblies of pertussis toxin subunits in vivo and their interaction with the ptl transport apparatus. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15322238&form=6&db=m Activation and inhibition of neuronal G protein-gated inwardly rectifying K(+) channels by P2Y nucleotide receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15322240&form=6&db=m 3-Morpholinylsydnonimine inhibits glutamatergic transmission in rat rostral ventrolateral medulla via peroxynitrite formation and adenosine release. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15326560&form=6&db=m Testosterone modulates K(+)ATP channels in sertoli cell membrane via the PLC-PIP2 pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15334663&form=6&db=m Characterization of the biological activities of uridine diphosphate in human dendritic cells: Influence on chemotaxis and CXCL8 release. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15337342&form=6&db=m Incidence of pertussis in persons < or =15 years of age in Valencia, Spain: seroprevalence of antibodies to pertussis toxin (PT) in children, adolescents and adults. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15339859&form=6&db=m Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15345909&form=6&db=m Food allergens are protected from degradation during CD23-mediated transepithelial transport. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15358239&form=6&db=m Ligand-induced alpha2-adrenoceptor endocytosis: relationship to Gi protein activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15358596&form=6&db=m CXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cell migration and promotion of intestinal barrier integrity. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15359086&form=6&db=m Carbachol-induced secretion and homologous desensitization in rat basophilic leukemia (RBL-2H3) cells transfected with human m2 muscarinic acetylcholine receptors. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15362046&form=6&db=m Role of phosphatidylinositol 3-kinase in the development of hepatocyte preconditioning. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15364021&form=6&db=m Noradrenaline-induced cation currents in isolated rat paratracheal ganglion neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15365299&form=6&db=m Acute ethanol-induced adenosine diphosphate ribosylation regulates the functional activity of rat striatal pertussis toxin-sensitive g proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15374752&form=6&db=m PGE2 increases the tetrodotoxin-resistant Nav1.9 sodium current in mouse DRG neurons via G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15375153&form=6&db=m Ligand-independent activation of peroxisome proliferator-activated receptor-gamma by insulin and C-peptide in kidney proximal tubular cells: dependent on phosphatidylinositol 3-kinase activity. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15381255&form=6&db=m PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15383304&form=6&db=m Entamoeba invadens contains the components of a classical adrenergic signaling system. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15383633&form=6&db=m Endogenous regulator of g protein signaling proteins reduce {mu}-opioid receptor desensitization and down-regulation and adenylyl cyclase tolerance in C6 cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15385434&form=6&db=m Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15388288&form=6&db=m Disruption of G(i/o) protein signaling in the nucleus accumbens results in a D1 dopamine receptor-mediated hyperactivity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15389590&form=6&db=m Upregulation of TNF-alpha-induced ICAM-1 surface expression by adenylate cyclase-dependent pathway in human endothelial cells. causal interaction,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15390118&form=6&db=m Tumor necrosis factor reduces cAMP production in rat microglia. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15447683&form=6&db=m Rho-mediated cytoskeletal rearrangement in response to LPA is functionally antagonized by Rac1 and PIP2. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15450086&form=6&db=m The beta-amyloid precursor protein controls a store-operated Ca2+ entry in cortical neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15450921&form=6&db=m Signalling pathways regulating human neutrophil migration induced by secretory phospholipases A2. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15451772&form=6&db=m G protein activation and cyclic AMP modulation by naloxone benzoylhydrazone in distinct layers of rat olfactory bulb. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15455260&form=6&db=m Pasteurella multocida toxin as a tool for studying Gq signal transduction. diagnostic usage,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15456404&form=6&db=m 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15465041&form=6&db=m Lysophosphatidic acid is a mediator of Trp-Lys-Tyr-Met-Val-d-Met-induced calcium influx. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15465923&form=6&db=m H3 autoreceptors modulate histamine synthesis through calcium/calmodulin- and cAMP-dependent protein kinase pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466624&form=6&db=m CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15467404&form=6&db=m Superoxide production from human polymorphonuclear leukocytes by human mannan-binding protein (MBP). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15470021&form=6&db=m Localization of marginal zone macrophages is regulated by C-C chemokine ligands 21/19. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15471896&form=6&db=m Up-regulation of interleukin-6 in human ovarian cancer cell via a Gi/PI3K-Akt/NF-kappaB pathway by lysophosphatidic acid, an ovarian cancer-activating factor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15471943&form=6&db=m The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15474718&form=6&db=m Adjuvanticity of native and detoxified adenylate cyclase toxin of Bordetella pertussis towards co-administered antigens. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15483227&form=6&db=m Chemokine receptor CCR6 transduces signals that activate p130Cas and alter cAMP-stimulated ion transport in human intestinal epithelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15484303&form=6&db=m Mechanisms mediating cholinergic antral circular smooth muscle contraction in rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15488383&form=6&db=m Differential detection of B. pertussis from B. parapertussis using a polymerase chain reaction (PCR) in presence of SYBR green1 and amplicon melting analysis. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15488596&form=6&db=m Pertussis toxin-sensitive pathway inhibits glucose-stimulated Ca2+ signals of rat islet beta-cells by affecting L-type Ca2+ channels and voltage-dependent K+ channels. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15500962&form=6&db=m D3 dopamine receptor activates phospholipase D through a pertussis toxin-insensitive pathway. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15505056&form=6&db=m Myelin/oligodendrocyte glycoprotein-specific T-cells induce severe optic neuritis in the C57BL/6 mouse. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15505760&form=6&db=m Insulin secretion is stimulated by ethanol extract of Anemarrhena asphodeloides in isolated islet of healthy Wistar and diabetic Goto-Kakizaki Rats. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15513978&form=6&db=m Cathine and norephedrine, both phenylpropanolamines, accelerate capacitation and then inhibit spontaneous acrosome loss. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15520494&form=6&db=m Pertussis toxin-sensitive G protein modulates the ability of histamine to stimulate cAMP production in the chick pineal gland. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15522276&form=6&db=m Activation of protein kinase B by adenosine A1 and A3 receptors in newborn rat cardiomyocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15522918&form=6&db=m Lysophosphatidic acid triggers calcium entry through a non-store-operated pathway in human neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15530428&form=6&db=m Glucagon release is regulated by tyrosine phosphatase and PI3-kinase activity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15530684&form=6&db=m High levels of antibody in adults three years after vaccination with a reduced antigen content diphtheria-tetanus-acellular pertussis vaccine. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15530863&form=6&db=m High extracellular calcium attenuates adipogenesis in 3T3-L1 preadipocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15539504&form=6&db=m Establishment of diagnostic cutoff points for levels of serum antibodies to pertussis toxin, filamentous hemagglutinin, and fimbriae in adolescents and adults in the United States. causal interaction,diagnostic usage,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15539555&form=6&db=m Bovine serum albumin-estrogen compounds differentially alter gonadotropin-releasing hormone-1 neuronal activity. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15539636&form=6&db=m Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15548655&form=6&db=m Presynaptic Cav2.1 and Cav2.2 differentially influence release dynamics at hippocampal excitatory synapses. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15557205&form=6&db=m TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease. diagnostic usage,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15569254&form=6&db=m Tyramine receptor (SER-2) isoforms are involved in the regulation of pharyngeal pumping and foraging behavior in Caenorhabditis elegans. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15571668&form=6&db=m Evidence for paracrine modulation of voltage-dependent calcium channels by amperometric analysis in cultured porcine adrenal chromaffin cells. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15572171&form=6&db=m The formation of skeletal muscle myotubes requires functional membrane receptors activated by extracellular ATP. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15572654&form=6&db=m Melatonin enhances leptin expression by rat adipocytes in the presence of insulin. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15574684&form=6&db=m Evidence for pleiotropic signaling at the mouse beta3-adrenoceptor revealed by SR59230A [3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate]. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15576391&form=6&db=m Tryptase inhibits motility of human spermatozoa mainly by activation of the mitogen-activated protein kinase pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15578376&form=6&db=m Prevalence of antibody to Bordetella pertussis antigens in serum specimens obtained from 1793 adolescents and adults. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15579146&form=6&db=m Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y receptor-mediated inhibition of voltage-gated Ca2+ channels. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15583264&form=6&db=m Antigenic divergence suggested by correlation between antigenic variation and pulsed-field gel electrophoresis profiles of Bordetella pertussis isolates in Japan. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15583746&form=6&db=m alpha-Adrenergic-mediated activation of human reconstituted fibrinogen receptor (integrin alphaIIbbeta3) in Chinese hamster ovary cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15589042&form=6&db=m Human H9 cells proliferation is differently controlled by vasoactive intestinal peptide or peptide histidine methionine: implication of a GTP-insensitive form of VPAC1 receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15593007&form=6&db=m The diphtheria and pertussis components of diphtheria-tetanus toxoids-pertussis vaccine should be genetically inactivated mutant toxins. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15596837&form=6&db=m The Epstein-Barr virus BILF1 gene encodes a G protein-coupled receptor that inhibits phosphorylation of RNA-dependent protein kinase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15598015&form=6&db=m [Reorganization of microtubule system in pulmonary endothelial cells in response to thrombin treatment] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15599940&form=6&db=m Functional differences and interactions between phenotypic subpopulations of olfactory ensheathing cells in promoting CNS axonal regeneration. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15605373&form=6&db=m Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15610155&form=6&db=m Fractalkine reduces N-methyl-d-aspartate-induced calcium flux and apoptosis in human neurons through extracellular signal-regulated kinase activation. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15611118&form=6&db=m OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15613498&form=6&db=m Visible light exposure induces VEGF gene expression through activation of retinoic acid receptor-alpha in retinoblastoma Y79 cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15621008&form=6&db=m Melatonin modulates intercellular communication among cultured chick astrocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15623786&form=6&db=m Interaction between mGluR8 and calcium channels in photoreceptors is sensitive to pertussis toxin and occurs via G protein betagamma subunit signaling. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15624099&form=6&db=m C-peptide stimulates ERK1/2 and JNK MAP kinases via activation of protein kinase C in human renal tubular cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15625079&form=6&db=m Sphingosine 1-phosphate regulates myogenic differentiation: a major role for S1P2 receptor. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15625281&form=6&db=m Sphingosine 1-phosphate receptors mediate the lipid-induced cAMP accumulation through cyclooxygenase-2/prostaglandin I2 pathway in human coronary artery smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15625782&form=6&db=m Pertussis toxin relaxes small arteries with no vascular lesions or vascular smooth muscle cell injury. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15626718&form=6&db=m Involvement of protein kinase A in cannabinoid receptor-mediated protection from oxidative neuronal injury. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15626752&form=6&db=m Involvement of G i/o proteins in nerve growth factor-stimulated phosphorylation and degradation of tuberin in PC-12 cells and cortical neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15626772&form=6&db=m Thromboxane prostanoid receptor signals through Gi protein to rapidly activate extracellular signal-regulated kinase in human airways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15629029&form=6&db=m Integration of G-protein coupled receptor signaling pathways for activation of a transcription factor (EGR-3). therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15632122&form=6&db=m Long lasting inhibition of adenylyl cyclase selectively mediated by inositol 1,4,5-trisphosphate-evoked calcium release. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15635042&form=6&db=m Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15640398&form=6&db=m M2, M3, and M4 receptor subtypes contribute to muscarinic potentiation of GABAergic inputs to spinal dorsal horn neurons. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15647401&form=6&db=m Activation of BK channels in GH3 cells by a c-PLA2-dependent G-protein signaling pathway. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15647486&form=6&db=m Morphine-induced chemotaxis and brain-derived neurotrophic factor expression in microglia. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15653093&form=6&db=m bFGF activates endothelial Ca2+-activated K+ channels involving G-proteins and tyrosine kinases. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15653554&form=6&db=m Elastin peptides activate extracellular signal-regulated kinase 1/2 via a Ras-independent mechanism requiring both p110gamma/Raf-1 and protein kinase A/B-Raf signaling in human skin fibroblasts. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15655507&form=6&db=m An investigation of whether agonist-selective receptor conformations occur with respect to M2 and M4 muscarinic acetylcholine receptor signalling via Gi/o and Gs proteins. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15657030&form=6&db=m Heterodimerization of mu- and delta-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15657046&form=6&db=m Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15657295&form=6&db=m Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15659118&form=6&db=m Ca2+ participates in alpha1B-adrenoceptor-mediated cAMP response in HEK293 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15659149&form=6&db=m Fish somatostatin sst3 receptor: comparison of radioligand and GTPgammaS binding, adenylate cyclase and phospholipase C activities reveals different agonist-dependent pharmacological signatures. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15659311&form=6&db=m Vascular effects of delta 9-tetrahydrocannabinol (THC), anandamide and N-arachidonoyldopamine (NADA) in the rat isolated aorta. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15659806&form=6&db=m The phosphotyrosine phosphatase eta mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15661400&form=6&db=m Human platelets exhibit chemotaxis using functional N-formyl peptide receptors. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15661818&form=6&db=m G protein {beta}{gamma} subunits mediate presynaptic inhibition of transmitter release from rat superior cervical ganglion neurones in culture. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15664559&form=6&db=m Dynamics of fast synaptic excitation during trains of stimulation in myenteric neurons of guinea-pig ileum. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15672410&form=6&db=m Effect of tumor necrosis factor-alpha on the reciprocal G-protein-induced regulation of norepinephrine release by the alpha2-adrenergic receptor. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15674632&form=6&db=m The receptor mechanism mediating the contractile response to adenosine on lung parenchymal strips from actively sensitised, allergen-challenged Brown Norway rats. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15678497&form=6&db=m Trypsin stimulates the phosphorylation of p42,44 mitogen-activated protein kinases via the proteinase-activated receptor-2 and protein kinase C epsilon in human cultured prostate stromal cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15683735&form=6&db=m G protein threshold behavior in the human neutrophil oxidant response: measurement of G proteins available for signaling in responding and nonresponding subpopulations. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15683740&form=6&db=m Regulation of the extracellular signal-regulated kinase pathway in adult myocardium: differential roles of G(q/11), Gi and G(12/13) proteins in signalling by alpha1-adrenergic, endothelin-1 and thrombin-sensitive protease-activated receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15684815&form=6&db=m The influence of hypotonicity on large-conductance calcium-activated potassium channels in human retinal pigment epithelial cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15685211&form=6&db=m An electrophysiological study of excitatory purinergic neuromuscular transmission in longitudinal smooth muscle of chicken anterior mesenteric artery. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15687374&form=6&db=m Endothelin (ET)-1-induced inhibition of ATP release from PC-12 cells is mediated by the ETB receptor: differential response to ET-1 on ATP, neuropeptide Y, and dopamine levels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15689381&form=6&db=m Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15689414&form=6&db=m beta-Adrenergic-responsive activation of extracellular signal-regulated protein kinases in salivary cells: role of epidermal growth factor receptor and cAMP. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15690317&form=6&db=m Insulin enhances vascular endothelial growth factor, interleukin-8, and plasminogen activator inhibitor 1 but not interleukin-6 release by human adipocytes. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15691377&form=6&db=m Proteolytic cleavage of pertussis toxin S1 subunit is not essential for its activity in mammalian cells. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15695395&form=6&db=m Activation of the {beta}-catenin/T-cell-specific transcription factor/lymphoid enhancer factor-1 pathway by plasminogen activators in ECV304 carcinoma cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15695615&form=6&db=m Mechanisms of action of angiotensin II on mammalian sperm function. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15698508&form=6&db=m MAPK activation via 5-hydroxytryptamine 1A receptor is involved in the neuroprotective effects of xaliproden. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15700028&form=6&db=m Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15705742&form=6&db=m Alpha 2-adrenergic agonist enrichment of spinophilin at the cell surface involves beta gamma subunits of Gi proteins and is preferentially induced by the alpha 2A-subtype. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15710251&form=6&db=m Sphingosine-1-phosphate induces early response gene expression in C6 glioma cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15710469&form=6&db=m Blood-brain barrier disruption and lesion localisation in experimental autoimmune encephalomyelitis with predominant cerebellar and brainstem involvement. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15710746&form=6&db=m Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk? causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15715086&form=6&db=m P0(106-125) is a neuritogenic epitope of the peripheral myelin protein P0 and induces autoimmune neuritis in C57BL/6 mice. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15719365&form=6&db=m T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15723813&form=6&db=m Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15724722&form=6&db=m Correlation of IgA, IgM and IgG antibody-detecting assays based on filamentous haemagglutinin, pertussis toxin and Bordetella pertussis sonicate in a strictly adult population. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15724723&form=6&db=m The seroepidemiology of Bordetella pertussis infection in Western Europe. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15728518&form=6&db=m Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15728708&form=6&db=m LPA2 receptor mediates mitogenic signals in human colon cancer cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15733090&form=6&db=m Coupling of 5-HT1A autoreceptors to inhibition of mitogen-activated protein kinase activation via G beta gamma subunit signaling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15733905&form=6&db=m Pharmacological modulation of the hyperpolarization-activated current (I f) in human atrial myocytes: focus on G protein-coupled receptors. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15734918&form=6&db=m Auxin-dependent cell division and cell elongation. 1-Naphthaleneacetic acid and 2,4-dichlorophenoxyacetic acid activate different pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15737330&form=6&db=m Pertussis toxin-sensitive modulation of glutamate transport by endothelin-1 type A receptors in glioma cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15737624&form=6&db=m Cyclic strain-mediated regulation of vascular endothelial cell migration and tube formation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15739119&form=6&db=m A role for heterotrimeric GTP-binding proteins and ERK1/2 in insulin-mediated, nitric-oxide-dependent, cyclic GMP production in human umbilical vein endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15739163&form=6&db=m Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinositol-3-kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15746245&form=6&db=m Pertussis toxin B-oligomer inhibits HIV infection and replication in hu-PBL-SCID mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15750457&form=6&db=m Immunogenicity and reactogenicity of a combined adsorbed tetanus toxoid, low dose diphtheria toxoid, five component acellular pertussis and inactivated polio vaccine in six-year-old children. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15753953&form=6&db=m Prolactin stimulates integrin-mediated adhesion of circulating mononuclear cells to endothelial cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15755905&form=6&db=m Coupling of metabotropic glutamate receptor 8 to N-type Ca2+ channels in rat sympathetic neurons. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15762197&form=6&db=m C-peptide increases the expression of vasopressin-activated calcium-mobilizing receptor gene through a G protein-dependent pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15763111&form=6&db=m A synthetic decapeptide from a conserved ZP3 protein domain induces the G protein-regulated acrosome reaction in bovine spermatozoa. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15763430&form=6&db=m Pertussis toxin-sensitive Gi/o proteins are involved in nerve growth factor-induced pro-survival Akt signaling cascade in PC12 cells. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15764707&form=6&db=m A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15773914&form=6&db=m Multiple pathways of apolipoprotein E signaling in primary neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15774519&form=6&db=m Reactive oxygen species contribute to the presynaptic action of extracellular ATP at the frog neuromuscular junction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15778280&form=6&db=m Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15778390&form=6&db=m Structure-function relationships among human cathelicidin peptides: dissociation of antimicrobial properties from host immunostimulatory activities. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15778904&form=6&db=m The receptor mechanism mediating the contractile response to adenosine on lung parenchymal strips from actively sensitised, allergen-challenged Brown Norway rats. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15792779&form=6&db=m Estrogen mediated inhibition of dopamine transport in the striatum: regulation by G alpha i/o. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15794661&form=6&db=m Proteolytic activation of protein kinase Calpha by peroxynitrite in stimulating cytosolic phospholipase A2 in pulmonary endothelium: involvement of a pertussis toxin sensitive protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15795178&form=6&db=m Beta-adrenoceptor-mediated vascular relaxation in spontaneously hypertensive rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15797812&form=6&db=m A pore-forming toxin produced by Aeromonas sobria activates Ca2+ dependent Cl- secretion. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15799022&form=6&db=m Go G-proteins mediate rapid heterologous desensitization of G-protein coupled receptors in Xenopus oocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15802488&form=6&db=m The role of beta-adrenergic receptor signaling in cardioprotection. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15804764&form=6&db=m The immunomodulator vasoactive intestinal peptide (VIP) does not affect experimental autoimmune uveitis (EAU) in B10.RIII mice. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15805145&form=6&db=m Baculovirus-expressed recombinant human zona pellucida glycoprotein-B induces acrosomal exocytosis in capacitated spermatozoa in addition to zona pellucida glycoprotein-C. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15805541&form=6&db=m Role of ceramide in Ca2+-sensing receptor-induced apoptosis. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15806113&form=6&db=m Artocarpol A stimulation of superoxide anion generation in neutrophils involved the activation of PLC, PKC and p38 mitogen-activated PK signaling pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15813899&form=6&db=m Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15814099&form=6&db=m Opioids inhibit purinergic nociceptors in the sensory neurons and fibres of rat via a G protein-dependent mechanism. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15816147&form=6&db=m A boarding school outbreak of pertussis in adolescents: value of laboratory diagnostic methods. diagnostic usage,ongoing research,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15816868&form=6&db=m Functional SDF1 alpha/CXCR4 signaling in the developing spinal cord. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15817160&form=6&db=m Macaque trophoblast migration is regulated by RANTES. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15817447&form=6&db=m Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15817833&form=6&db=m Nongenomic effect of thyroid hormone on free-radical production in human polymorphonuclear leukocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15821110&form=6&db=m Atrial natriuretic peptide inhibits the actions of FSH and forskolin in meiotic maturation of pig oocytes via different signalling pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15821751&form=6&db=m The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15829433&form=6&db=m Pharmacological effects mediated by UDP-glucose that are independent of P2Y14 receptor expression. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15831818&form=6&db=m Novel mitogenic effect of adenosine on coronary artery smooth muscle cells: role for the A1 adenosine receptor. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15838097&form=6&db=m Future vaccine development at NICHD. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15838308&form=6&db=m Cytodifferentiation Enhances Erk Activation Induced by Endothelin-1 in Primary Cultured Astrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15840650&form=6&db=m Cyclic AMP mediates keratinocyte directional migration in an electric field. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15840934&form=6&db=m [The effect of G protein regulator on pollen germination and [Ca2+]i variation in Pyrus serotina Rehd. pollen.] ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15842741&form=6&db=m Reciprocal inhibition of voltage-gated potassium currents (I K(V)) by activation of cannabinoid CB1 and dopamine D1 receptors in ON bipolar cells of goldfish retina. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15842775&form=6&db=m Activation of human tonsil and skin mast cells by agonists of proteinase activated receptor-2. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15843520&form=6&db=m Granulysin, a cytolytic molecule, is also a chemoattractant and proinflammatory activator. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15845471&form=6&db=m Pertussis toxin and adenylate cyclase toxin provide a one-two punch for establishment of Bordetella pertussis infection of the respiratory tract. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15845487&form=6&db=m Identification and characterization of human surfactant protein A binding protein of Mycoplasma pneumoniae. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15857394&form=6&db=m 5-HT receptors couple to activation of Akt, but not extracellular-regulated kinase (ERK), in cultured hippocampal neurons. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15857395&form=6&db=m STAT5A interacts with and is phosphorylated upon activation of the mu-opioid receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15857399&form=6&db=m Stromal cell-derived factor-1alpha directly modulates voltage-dependent currents of the action potential in mammalian neuronal cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15857684&form=6&db=m Biochemical demonstration of mu-opioid receptor association with Gsalpha: enhancement following morphine exposure. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15862793&form=6&db=m Effects of pertussis toxin on electroacupuncture-produced anti-hyperalgesia in inflamed rats. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15869514&form=6&db=m G-protein coupled activation of potassium channels by endogenous neuropeptides in snail neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15869763&form=6&db=m Plasmin induces smooth muscle cell proliferation. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15874933&form=6&db=m Urokinase-induced smooth muscle cell responses require distinct signaling pathways: a role for the epidermal growth factor receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878715&form=6&db=m Evidence for two atypical conformations of beta-adrenoceptors and their interaction with Gi proteins. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878870&form=6&db=m Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15879004&form=6&db=m Effects of beta-phenylethylamine on dopaminergic neurons of the ventral tegmental area in the rat: a combined electrophysiological and microdialysis study. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15879099&form=6&db=m Pertussis toxin (PTX) B subunit and the nontoxic PTX mutant PT9K/129G inhibit Tat-induced TGF-beta production by NK cells and TGF-beta-mediated NK cell apoptosis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15880429&form=6&db=m Novel CD47-dependent intercellular adhesion modulates cell migration. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15888246&form=6&db=m Xaliproden (SR57746A) induces 5-HT1A receptor-mediated MAP kinase activation in PC12 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15888256&form=6&db=m IL-10 enhances CCL2 release and chemotaxis induced by CCL16 in human monocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15901601&form=6&db=m Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15901805&form=6&db=m The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15902435&form=6&db=m Mice lacking the IFN-gamma receptor or fyn develop severe experimental autoimmune uveoretinitis characterized by different immune responses. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15907808&form=6&db=m Involvement of p38 MAP kinase-mediated cytochrome c release on sphingosine-1-phosphate (S1P)- and N-monomethyl-S1P-induced cell death of PC12 cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15908120&form=6&db=m Cocaine- and amphetamine-regulated transcript (CART) peptide activates the extracellular signal-regulated kinase (ERK) pathway in AtT20 cells via putative G-protein coupled receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15908393&form=6&db=m Infection of newborn piglets with Bordetella pertussis: a new model for pertussis. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911063&form=6&db=m Determinants of natriuretic peptide gene expression. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911093&form=6&db=m Long-term functional impairment of hemopoietic progenitor cells engineered to express the S1 catalytic subunit of pertussis toxin. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15914605&form=6&db=m LPA and S1P increase corneal epithelial and endothelial cell transcellular resistance. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15919053&form=6&db=m Eosinophil migration induced by mast cell chymase is mediated by extracellular signal-regulated kinase pathway. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15922942&form=6&db=m PTX cruiser: driving autoimmunity via TLR4. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15923116&form=6&db=m Exploring cargo transport mechanics in the type IV secretion systems. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15925428&form=6&db=m Serotonin receptor activation leads to neurite outgrowth and neuronal survival. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15925485&form=6&db=m Adenylyl cyclase type-VIII activity is regulated by G(betagamma) subunits. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15927208&form=6&db=m CCR2 expression by brain microvascular endothelial cells is critical for macrophage transendothelial migration in response to CCL2. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15927850&form=6&db=m Human CC chemokine CCL23, a ligand for CCR1, induces endothelial cell migration and promotes angiogenesis. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15928320&form=6&db=m The macrophage-derived lectin, MNCF, activates neutrophil migration through a pertussis toxin-sensitive pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15934932&form=6&db=m Presynaptic inhibition of transmitter release from rat sympathetic neurons by bradykinin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15935492&form=6&db=m Somatostatin, misoprostol and galanin inhibit gastrin- and PACAP-stimulated secretion of histamine and pancreastatin from ECL cells by blocking specific Ca2+ channels. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15936740&form=6&db=m Disruption of inhibitory G-proteins mediates a reduction in atrial beta-adrenergic signaling by enhancing eNOS expression. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15937148&form=6&db=m Modulation of Ca2+ channels by opioid receptor-like 1 receptors natively expressed in rat stellate ganglion neurons innervating cardiac muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15944022&form=6&db=m Regulation of limbic status epilepticus by hippocampal galanin type 1 and type 2 receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15946646&form=6&db=m Lysophosphatidylserine stimulates leukemic cells but not normal leukocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15946966&form=6&db=m Phenylephrine acts via IP3-dependent intracellular NO release to stimulate L-type Ca2+ current in cat atrial myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15948714&form=6&db=m Purkinje cell protein-2 (Pcp2) stimulates differentiation in PC12 cells by Gbetagamma-mediated activation of Ras and p38 MAPK. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15950201&form=6&db=m Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15950987&form=6&db=m Differential functional effects of two 5-HT4 receptor isoforms in adult cardiomyocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15951336&form=6&db=m Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15956406&form=6&db=m Analysis of Bordetella pertussis populations in European countries with different vaccination policies. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15958831&form=6&db=m Pertussis toxin B-oligomer dissociates T cell activation and HIV replication in CD4 T cells released from infected lymphoid tissue. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15964603&form=6&db=m Differential ion current activation by human 5-HT(1A) receptors in Xenopus oocytes: evidence for agonist-directed trafficking of receptor signalling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15965495&form=6&db=m M(2) and M(3) muscarinic receptor-mediated contractions in longitudinal smooth muscle of the ileum studied with receptor knockout mice. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15965949&form=6&db=m Progesterone primes zona pellucida-induced activation of phospholipase A2 during acrosomal exocytosis in guinea pig spermatozoa. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15972522&form=6&db=m Production of nontypeable Haemophilus influenzae HtrA by recombinant Bordetella pertussis with the use of filamentous hemagglutinin as a carrier. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15974446&form=6&db=m Differential modulatory effects of cholera toxin and pertussis toxin on pain behavior induced by TNF-alpha, interleukin-1beta and interferon-gamma injected intrathecally. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15979279&form=6&db=m Activation of muscarinic M(4) receptor augments NGF-induced pro-survival Akt signaling in PC12 cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15979846&form=6&db=m Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: A mechanism requiring PTX-insensitive G proteins, ERK and JNK. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15995175&form=6&db=m Sphingosine-1-phosphate inhibition of placental trophoblast differentiation through a G(i)-coupled receptor response. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15995354&form=6&db=m Phospholipase C-beta3 mediates the thrombin-induced Ca2+ response in glial cells. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15996654&form=6&db=m Pregnenolone sulfate acts through a G-protein-coupled sigma1-like receptor to enhance short term facilitation in adult hippocampal neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15997228&form=6&db=m Functional expression of the P2Y14 receptor in murine T-lymphocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16002578&form=6&db=m Heterotrimeric G proteins and the platelet-derived growth factor receptor-beta contribute to hypoxic proliferation of smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16005025&form=6&db=m Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16006019&form=6&db=m A CpG-containing oligodeoxynucleotide as an efficient adjuvant counterbalancing the Th1/Th2 immune response in diphtheria-tetanus-pertussis vaccine. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16007180&form=6&db=m Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16014705&form=6&db=m ATP stimulates Na+-glucose cotransporter activity via cAMP and p38 MAPK in renal proximal tubule cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16024262&form=6&db=m FMS*Calciumfluor specifically increases mRNA levels and induces signaling via MAPK 42,44 and not FAK in differentiating rat osteoblasts. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16025138&form=6&db=m Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16025745&form=6&db=m Effects of angiotensin II on the action potential durations of atrial myocytes in hypertensive rats. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16033468&form=6&db=m Secretion of heterologous proteins in Bacillus subtilis can be improved by engineering cell components affecting post-translocational protein folding and degradation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16034127&form=6&db=m Involvement of the Rho-kinase/myosin light chain kinase pathway on human monocyte chemotaxis induced by ATL-1, an aspirin-triggered lipoxin A4 synthetic analog. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16038799&form=6&db=m Beta-arrestin2 enhances beta2-adrenergic receptor-mediated nuclear translocation of ERK. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16039985&form=6&db=m TG1019/OXE, a Galpha(i/o)-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16043658&form=6&db=m Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16045757&form=6&db=m An antimicrobial peptide tachyplesin acts as a secondary secretagogue and amplifies lipopolysaccharide-induced hemocyte exocytosis. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16046880&form=6&db=m Ethanol triggers neural crest apoptosis through the selective activation of a pertussis toxin-sensitive G protein and a phospholipase Cbeta-dependent Ca2+ transient. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16047340&form=6&db=m IL-15 induces mast cell migration via a pertussis toxin-sensitive receptor. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16047385&form=6&db=m CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16050521&form=6&db=m Age-specific long-term course of IgG antibodies to pertussis toxin after symptomatic infection with Bordetella pertussis. diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16052566&form=6&db=m Cross-talk among epidermal growth factor, Ap(5)A, and nucleotide receptors causing enhanced ATP Ca(2+) signaling involves extracellular kinase activation in cerebellar astrocytes. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16053916&form=6&db=m Activation of delta-, kappa-, and mu-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16054273&form=6&db=m Comparison of acellular pertussis vaccines-induced immunity against infection due to Bordetella pertussis variant isolates in a mouse model. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16055946&form=6&db=m Second-generation antipsychotic drugs, olanzapine, quetiapine, and clozapine enhance neurite outgrowth in PC12 cells via PI3K/AKT, ERK, and pertussis toxin-sensitive pathways. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16079065&form=6&db=m Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic alpha-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16079279&form=6&db=m G-protein-coupled glucocorticoid receptors on the pituitary cell membrane. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16081051&form=6&db=m Isoflurane preconditioning decreases glutamate receptor overactivation-induced Purkinje neuronal injury in rat cerebellar slices. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16081896&form=6&db=m Strain variation among Bordetella pertussis isolates in finland, where the whole-cell pertussis vaccine has been used for 50 years. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16085656&form=6&db=m Characterization of phosphatidylinositol-specific phospholipase C (PI-PLC) from Lilium daviddi pollen. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16095736&form=6&db=m Comparison of real-time PCR and pyrosequencing for typing Bordetella pertussis toxin subunit 1 variants. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16096282&form=6&db=m Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16098594&form=6&db=m A G protein-associated ERK pathway is involved in LPS-induced proliferation and a PTK-associated p38 MAPK pathway is involved in LPS-induced differentiation in resting B cells. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16099448&form=6&db=m Activation of a pertussis toxin-sensitive, inhibitory G-protein is necessary for steroid-mediated oocyte maturation in spotted seatrout. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16100051&form=6&db=m Cell-signaling evidence for adenosine stimulation of coronary smooth muscle proliferation via the A1 adenosine receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16101445&form=6&db=m Bacterial toxins: potential weapons against HIV infection. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16103237&form=6&db=m Vascular smooth muscle overexpression of G protein-coupled receptor kinase 5 elevates blood pressure, which segregates with sex and is dependent on Gi-mediated signaling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16105834&form=6&db=m The synthetic cannabinoid R(+)WIN 55,212-2 inhibits the interleukin-1 signaling pathway in human astrocytes in a cannabinoid receptor-independent manner. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16109507&form=6&db=m Leukotriene D4 potentiates fibronectin-induced migration of human lung fibroblasts. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16109883&form=6&db=m The P2Y14 receptor of airway epithelial cells: coupling to intracellular Ca2+ and IL-8 secretion. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16111867&form=6&db=m Sphingosine 1-phosphate receptors mediate stimulatory and inhibitory signalings for expression of adhesion molecules in endothelial cells. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16116468&form=6&db=m Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16123167&form=6&db=m Rapid estrogenic regulation of extracellular signal- regulated kinase 1/2 signaling in cerebellar granule cells involves a G protein- and protein kinase A-dependent mechanism and intracellular activation of protein phosphatase 2A. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16127206&form=6&db=m Duality in the mastoparan action on glucose transport in rat adipocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16135702&form=6&db=m Enhanced inhibition of L-type Ca2+ current by beta3-adrenergic stimulation in failing rat heart. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16140887&form=6&db=m Eicosapentaenoic acid suppresses cell proliferation in MCF-7 human breast cancer xenografts in nude rats via a pertussis toxin-sensitive signal transduction pathway. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16143328&form=6&db=m Genetic deficiency of C3 as well as CNS-targeted expression of the complement inhibitor sCrry ameliorates experimental autoimmune uveoretinitis. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16144970&form=6&db=m Functional domains of the mouse beta3-adrenoceptor associated with differential G protein coupling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16148159&form=6&db=m Differential calcium regulation of proinflammatory activities in human neutrophils exposed to the neuropeptide pituitary adenylate cyclase-activating protein. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16162176&form=6&db=m The signaling pathway in photoresponses that may be mediated by visual pigments in erythrophores of Nile tilapia. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16164753&form=6&db=m Metallothionein mediates leukocyte chemotaxis. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16166080&form=6&db=m Rhythmic expression of adenylyl cyclase VI contributes to the differential regulation of serotonin N-acetyltransferase by bradykinin in rat pineal glands. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16171811&form=6&db=m Both alpha(1A)- and alpha(1B)-adrenergic receptors crosstalk to down regulate beta(1)-ARs in mouse heart: coupling to differential PTX-sensitive pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16172105&form=6&db=m Serotonin and melatonin, neurohormones for homeostasis, as novel inhibitors of infections by the intracellular parasite chlamydia. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16172123&form=6&db=m Transactivation of CXCR4 by the insulin-like growth factor-1 receptor (IGF-1R) in human MDA-MB-231 breast cancer epithelial cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16172164&form=6&db=m Calcitonin gene-related peptide activates different signaling pathways in mesenteric lymphatics of guinea pigs. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16181623&form=6&db=m Metabotropic P2Y1 receptors inhibit P2X3 receptor-channels in rat dorsal root ganglion neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16183044&form=6&db=m Evidence that inward rectifier K+ channels mediate relaxation by the PGI2 receptor agonist cicaprost via a cyclic AMP-independent mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16183075&form=6&db=m Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16186116&form=6&db=m The P2Y2 nucleotide receptor interacts with alphav integrins to activate Go and induce cell migration. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16186630&form=6&db=m Inhibition and superactivation of the calcium-stimulated isoforms of adenylyl cyclase: role of Gbetagamma dimers. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16189696&form=6&db=m Involvement of the betagamma subunits of G proteins in the cAMP response induced by stimulation of the histamine H1 receptor. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16199532&form=6&db=m Identification of a novel extracellular cation-sensing G-protein-coupled receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16199931&form=6&db=m Sphingosine 1-phosphate induces alpha-smooth muscle actin expression in lung fibroblasts via Rho-kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16204059&form=6&db=m Oncogenes and Angiogenesis: down-regulation of thrombospondin-1 in normal fibroblasts exposed to factors from cancer cells harboring mutant ras. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16204467&form=6&db=m EP(4) prostanoid receptor coupling to a pertussis toxin-sensitive inhibitory G protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16210594&form=6&db=m Modulation of CD4 Th cell differentiation by ganglioside GD1a in vitro. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16210647&form=6&db=m The chemokines CXCL9, CXCL10, and CXCL11 differentially stimulate G alpha i-independent signaling and actin responses in human intestinal myofibroblasts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16210651&form=6&db=m Nonpathogenic, environmental fungi induce activation and degranulation of human eosinophils. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16211245&form=6&db=m G protein-coupled APJ receptor signaling induces focal adhesion formation and cell motility. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16219804&form=6&db=m CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid beta 1-42 peptide by up-regulating the expression of the G-protein- coupled receptor mFPR2. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16221874&form=6&db=m Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16226254&form=6&db=m Differential CCR1-mediated chemotaxis signaling induced by human CC chemokine HCC-4/CCL16 in HOS cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16227319&form=6&db=m Expression and muscarinic receptor coupling of Lyn kinase in cultured human airway smooth muscle cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16233741&form=6&db=m Cell cycle analysis of Chinese hamster ovary cells stimulated by phosphatidic acid in serum-free culture. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16234484&form=6&db=m Identification of a potent inverse agonist at a constitutively active mutant of human P2Y12 receptor. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16237757&form=6&db=m Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16239529&form=6&db=m Influence of CR3 (CD11b/CD18) expression on phagocytosis of Bordetella pertussis by human neutrophils. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16242307&form=6&db=m G protein betagamma11 complex translocation is induced by Gi, Gq and Gs coupling receptors and is regulated by the alpha subunit type. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16242672&form=6&db=m Lysophosphatidic acid stimulates cell proliferation in rat chondrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16249373&form=6&db=m {delta} Opioid Receptors Stimulate Akt-Dependent Phosphorylation of c-jun in T Cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16249929&form=6&db=m Diphtheria, tetanus and pertussis antibodies in 10-year-old children before and after a booster dose of three toxoids: implications for the timing of a booster dose. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16251475&form=6&db=m Regulation of homocysteine-induced MMP-9 by ERK1/2 pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16260092&form=6&db=m Neutrophil activation induced by the lectin KM+ involves binding to CXCR2. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16267108&form=6&db=m Sphingosine-1-phosphate activates BKCa channels independently of G protein-coupled receptor in human endothelial cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16271370&form=6&db=m Protein kinase C inhibitor chelerythrine attenuates the morphine-induced excitatory amino acid release and reduction of the antinociceptive effect of morphine in rats injected intrathecally with pertussis toxin. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16272470&form=6&db=m Antigenic divergence of Bordetella pertussis isolates in Taiwan. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16278291&form=6&db=m Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16280323&form=6&db=m beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16283845&form=6&db=m Third prize: Prostaglandin E(2)-3 receptor is involved in ureteral contractility in obstruction. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16284629&form=6&db=m Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16289487&form=6&db=m Antinociception following application of DAMGO to the basolateral amygdala results from a direct interaction of DAMGO with Mu opioid receptors in the amygdala. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16291515&form=6&db=m Oxidant-mediated activation of cytosolic phospholipase a(2) in pulmonary endothelium: role of protein kinase C alpha and a pertussis toxin-sensitive protein. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16294220&form=6&db=m Pertussis toxin inhibits neutrophil recruitment to delay antibody-mediated clearance of Bordetella pertussis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16297200&form=6&db=m Mouse lymphoid tissue contains distinct subsets of langerin/CD207 dendritic cells, only one of which represents epidermal-derived Langerhans cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16298647&form=6&db=m Role of chemokine signaling pathways in pancreatic islet rejection during allo- and xenotransplantation. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16299067&form=6&db=m Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16299553&form=6&db=m The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16300797&form=6&db=m Characteristics of acid extrusion from Chinese hamster ovary cells expressing different prostaglandin EP receptors. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16301620&form=6&db=m An hour after immunization peritoneal B-1 cells are activated to migrate to lymphoid organs where within 1 day they produce IgM antibodies that initiate elicitation of contact sensitivity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16301839&form=6&db=m Calcium signals activated by arachidonic acid in embryonic chick ciliary ganglion neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16301993&form=6&db=m The G12/13-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16310401&form=6&db=m Potent histamine-releasing activity of atrahagin, a novel snake venom metalloproteinase. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16311911&form=6&db=m Role of MMP-2 in PKCdelta-mediated inhibition of Na+ dependent Ca2+ uptake in microsomes of pulmonary smooth muscle: involvement of a pertussis toxin sensitive protein. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16315741&form=6&db=m The reemergence of pertussis in immunized populations: a case study. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16317352&form=6&db=m Halothane inhibits spontaneous calcium oscillations via adenosine A1 receptors. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16317705&form=6&db=m Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16318846&form=6&db=m Caveolae modulate excitation-contraction coupling and beta(2)-adrenergic signalling in adult rat ventricular myocytes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16322354&form=6&db=m Induction of adenosine A1 receptor expression by pertussis toxin via an adenosine 5'-diphosphate ribosylation-independent pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16327020&form=6&db=m Gs and Gi coupling of adrenomedullin in adult rat ventricular myocytes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16332987&form=6&db=m Chemokine-directed trafficking of receptor stimulus to different g proteins: selective inducible and constitutive signaling by human herpesvirus 6-encoded chemokine receptor u51. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16333349&form=6&db=m Genetic and antigenic analysis of Bordetella pertussis isolates recovered from clinical cases in Ontario, Canada, before and after the introduction of the acellular pertussis vaccine. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16334221&form=6&db=m [Molecular genetic characteristics of the B. pertussis strains isolated in different periods of the pertussis epidemic process] causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16336222&form=6&db=m An aplysia dopamine1-like receptor: molecular and functional characterization. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16339111&form=6&db=m Sphingosylphosphorylcholine induces proliferation of human adipose tissue-derived mesenchymal stem cells via activation of JNK. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16339199&form=6&db=m Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16343781&form=6&db=m GABA(B) heterodimeric receptors promote Ca(2+) influx via store-operated channels in rat cortical neurons and transfected chinese hamster ovary cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16345022&form=6&db=m Mixture model analysis for establishing a diagnostic cut-off point for pertussis antibody levels. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16345030&form=6&db=m cAMP cascade (PKA, Epac, adenylyl cyclase, Gi, and phosphodiesterases) regulates myelin phagocytosis mediated by complement receptor-3 and scavenger receptor-AI/II in microglia and macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16352191&form=6&db=m Different regulation of ERK1/2 activation by beta-adrenergic receptor subtypes in adult mouse cardiomyocytes. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16352342&form=6&db=m The incidence of Bordetella pertussis infections estimated in the population from a combination of serological surveys. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16352704&form=6&db=m Hypocretin (orexin) receptor subtypes differentially enhance acetylcholine release and activate g protein subtypes in rat pontine reticular formation. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16355273&form=6&db=m CCR1 acts downstream of NFAT2 in osteoclastogenesis and enhances cell migration. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16365188&form=6&db=m Pancreatic polypeptide-fold peptide receptors and angiotensin II-induced renal vasoconstriction. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16365309&form=6&db=m The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16368894&form=6&db=m Lysophosphatidylserine Stimulates L2071 Mouse Fibroblast Chemotactic Migration via a Process Involving Pertussis Toxin-Sensitive Trimeric G-Proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16371866&form=6&db=m A modified vaccine reduces the rate of large injection site reactions to the preschool booster dose of diphtheria-tetanus-acellular pertussis vaccine: results of a randomized, controlled trial. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16376326&form=6&db=m Alterations of the preproenkephalin system in cardiac hypertrophy and its role in atrioventricular conduction. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16381660&form=6&db=m Endocrine disrupting chemical atrazine causes degranulation through Gq/11 protein-coupled neurosteroid receptor in mast cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16386710&form=6&db=m Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16389067&form=6&db=m Triglyceride modulation by acifran analogs: activity towards the niacin high and low affinity G protein-coupled receptors HM74A and HM74. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16389302&form=6&db=m Bordetella pertussis, the Causative Agent of Whooping Cough, Evolved from a Distinct, Human-Associated Lineage of B. bronchiseptica. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16389646&form=6&db=m Influence of C-peptide on early glomerular changes in diabetic mice. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16390330&form=6&db=m The allosteric enhancer PD81,723 increases chimaeric A1/A2A adenosine receptor coupling with Gs. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16390332&form=6&db=m Involvement of the Gi/o/cGMP/PKG pathway in the AT2-mediated inhibition of outer cortex proximal tubule Na+-ATPase by Ang-(1-7). therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16390708&form=6&db=m Gi protein-mediated translocation of serine/threonine phosphatase to the plasma membrane and apoptosis of ovarian cancer cell in response to gonadotropin-releasing hormone antagonist cetrorelix. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16393968&form=6&db=m Dopamine selectively induces migration and homing of naive CD8+ T cells via dopamine receptor D3. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16393986&form=6&db=m Pertussis toxin B-oligomer suppresses IL-6 induced HIV-1 and chemokine expression in chronically infected U1 cells via inhibition of activator protein 1. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16404130&form=6&db=m Lysophosphatidic acid (LPA) induces plasma exudation and histamine release in mice via LPA receptors. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16405927&form=6&db=m Presence of delta opioid receptors on a subset of hypothalamic gonadotropin releasing hormone (GnRH) neurons. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16407456&form=6&db=m G protein-associated, specific membrane binding sites mediate the neuroprotective effect of dehydroepiandrosterone. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16407557&form=6&db=m Single transmembrane domain insulin-like growth factor-II/mannose-6-phosphate receptor regulates central cholinergic function by activating a G-protein-sensitive, protein kinase C-dependent pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16410279&form=6&db=m Dynamic regulation of glycinergic input to spinal dorsal horn neurones by muscarinic receptor subtypes in rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16410672&form=6&db=m Mechanism of D(2) agonist-induced inhibition of GH secretion from human GH-secreting adenoma cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16410887&form=6&db=m Immunogenicity of a combined DTPa-HB vaccine co-administered with Haemophilus influenzae type B conjugate vaccine (PRP-T) for primary and booster vaccinations. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16415087&form=6&db=m Regulation of volume-sensitive osmolyte efflux from human SH-SY5Y neuroblastoma cells following activation of lysophospholipid receptors. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16415102&form=6&db=m Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16415907&form=6&db=m Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16417588&form=6&db=m Differential negative coupling of type 3 metabotropic glutamate receptor to cyclic GMP levels in neurons and astrocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16427077&form=6&db=m Functional remodeling in post-myocardial infarcted rats: focus on beta-adrenoceptor subtypes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16436499&form=6&db=m Comparison of the relative efficacy and potency of mu-opioid agonists to activate Galpha(i/o) proteins containing a pertussis toxin-insensitive mutation. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16440124&form=6&db=m Survey of pertussis in patients with prolonged cough. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16441432&form=6&db=m Neutrophil chemotaxis by pathogen-associated molecular patterns--formylated peptides are crucial but not the sole neutrophil attractants produced by Staphylococcus aureus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16441556&form=6&db=m Parallel signaling pathways of melatonin in the pancreatic beta-cell. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16442093&form=6&db=m Potentiation of nicotinic currents by bradykinin in the paratracheal ganglia neurons of rats. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16443217&form=6&db=m Role of cannabinoid receptors in Delta-9-tetrahydrocannabinol suppression of IL-12p40 in mouse bone marrow-derived dendritic cells infected with Legionella pneumophila. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16446505&form=6&db=m Mini-dystrophin Expression Down-regulates Overactivation of G Protein-mediated IP3 Signaling Pathway in Dystrophin-deficient Muscle Cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16452215&form=6&db=m Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16452723&form=6&db=m Rapid effects of pesticides on human granulosa-lutein cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16455058&form=6&db=m Functional expression of metabotropic GABA(B) receptors in primary cultures of astrocytes from rat cerebral cortex. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16456099&form=6&db=m Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16456531&form=6&db=m Engagement of CD47 inhibits the contact hypersensitivity response via the suppression of motility and B7 expression by Langerhans cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16458323&form=6&db=m Differential cardiotoxic/cardioprotective effects of beta-adrenergic receptor subtypes in myocytes and fibroblasts in doxorubicin cardiomyopathy. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16459350&form=6&db=m Effects of estrogenic xenobiotics on human and mouse spermatozoa. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16462859&form=6&db=m Induction of humoral immunity in response to immunization with recombinant Mycobacterium bovis BCG expressing the S1 subunit of Bordetella pertussis toxin. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16467336&form=6&db=m Evaluation of a tetraplex microsphere assay for Bordetella pertussis antibodies. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16467404&form=6&db=m CXCR3 chemokine receptor-induced chemotaxis in human airway epithelial cells: role of p38 MAPK and PI3K signaling pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16469439&form=6&db=m SDF1alpha/CXCR4 signaling stimulates beta-catenin transcriptional activity in rat neural progenitors. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16470810&form=6&db=m Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through G(i)-protein-coupled receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16474418&form=6&db=m Agonist-specific activation of the beta2-adrenoceptor/Gs-protein and beta2-adrenoceptor/Gi-protein pathway in adult rat ventricular cardiomyocytes. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16479542&form=6&db=m Pertussis toxin as an adjuvant suppresses the number and function of CD4(+)CD25(+) T regulatory cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16480614&form=6&db=m [The role of different subtypes of G protein in the secretory function of macrophages stimulated by activated complement following severe burn injury] unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16480852&form=6&db=m Structure-function analysis of Frizzleds. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16482570&form=6&db=m Vascular endothelial growth factor production in human prostate cancer cells is stimulated by overexpression of platelet 12-lipoxygenase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16483540&form=6&db=m Involvement of G(i/o) in the PAR-4-induced NO production in endothelial cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16487264&form=6&db=m HIGH GLUCOSE-INDUCED INHIBITION OF 2-DEOXYGLUCOSE UPTAKE IS MEDIATED BY cAMP, PROTEIN KINASE C, OXIDATIVE STRESS AND MITOGEN-ACTIVATED PROTEIN KINASES IN MOUSE EMBRYONIC STEM CELLS. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16487757&form=6&db=m Lysophosphatidic acid induces chemotaxis in MC3T3-E1 osteoblastic cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16487961&form=6&db=m Activation of P2Y1 receptor triggers two calcium signaling pathways in bone marrow erythroblasts. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16490345&form=6&db=m Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16492384&form=6&db=m The signaling pathways linking to lysophosphatidic acid-promoted meiotic maturation in mice. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16497513&form=6&db=m Effect of relevant culture parameters on Pertussis Toxin expression by Bordetella pertussis. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16500113&form=6&db=m Fed-batch cultivation of Bordetella pertussis: metabolism and Pertussis Toxin production. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16504475&form=6&db=m Vascular smooth muscle migration and proliferation in response to lysophosphatidic acid (LPA) is mediated by LPA receptors coupling to Gq. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507880&form=6&db=m International Union of Pharmacology LVII: Recommendations for the Nomenclature of Receptors for Relaxin Family Peptides. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16508938&form=6&db=m Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: Regulation of synovial proliferation and inflammatory gene expression. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16510724&form=6&db=m Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16510765&form=6&db=m C-peptide signals via Galpha i to protect against TNF-alpha-mediated apoptosis of opossum kidney proximal tubular cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16511346&form=6&db=m Sphingosine 1-phosphate-induced signal transduction in cat esophagus smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16513646&form=6&db=m Membrane electrical activity elicits inositol 1,4,5-trisphosphate-dependent slow Ca2+ signals through a Gbetagamma/phosphatidylinositol 3-kinase gamma pathway in skeletal myotubes. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16516161&form=6&db=m High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16516270&form=6&db=m Lysophosphatidic acid-induced changes in cAMP profiles in young and senescent human fibroblasts as a clue to the ageing process. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16516357&form=6&db=m Interchangeability of two diphtheria and tetanus toxoids, acellular pertussis, inactivated poliovirus, Haemophilus influenzae type b conjugate vaccines as a fourth dose in 15-20-month-old toddlers. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16521006&form=6&db=m Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16521184&form=6&db=m IL-1beta activates p44/42 and p38 mitogen-activated protein kinases via different pathways in cat esophageal smooth muscle cells. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16522775&form=6&db=m Characterization of serological responses to pertussis. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16524757&form=6&db=m Characterization of a neuronal cell line expressing native human melanin-concentrating hormone receptor 1 (MCHR1). therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16525132&form=6&db=m Short- and long-term regulation of adenylyl cyclase activity by delta-opioid receptor are mediated by Galphai2 in neuroblastoma N2A cells. ongoing research,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16527273&form=6&db=m Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16532655&form=6&db=m [Prophylaxis of pertussis: development and use of acellular pertussis vaccine] diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16537795&form=6&db=m Role of renal sympathetic nerves in regulating renovascular responses to angiotensin II in spontaneously hypertensive rats. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16538027&form=6&db=m Characterization of muscarinic receptor-mediated cationic currents in longitudinal smooth muscle cells of mouse small intestine. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16542440&form=6&db=m Analysis of Bordetella pertussis pertactin and pertussis toxin types from Queensland, Australia, 1999-2003. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16543720&form=6&db=m Endothelin-1 regulates proliferative responses, both alone and synergistically with PDGF, in rat tracheal smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16545401&form=6&db=m Adenylyl cyclase type II activity is regulated by two different mechanisms: implications for acute and chronic opioid exposure. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16549032&form=6&db=m Antimigraine drug, zolmitriptan, inhibits high-voltage activated calcium currents in a population of acutely dissociated rat trigeminal sensory neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16553950&form=6&db=m CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16554657&form=6&db=m Sphingosine 1-phosphate: a novel stimulator of aldosterone secretion. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16556317&form=6&db=m Evaluation of real-time PCR for diagnosis of Bordetella pertussis infection. diagnostic usage,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16556853&form=6&db=m Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16567419&form=6&db=m 5-Oxo-Eicosatetraenoic Acid-Induced Chemotaxis: Identification of a Responsible Receptor hGPCR48 and Negative Regulation by G Protein G12/13. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16567978&form=6&db=m Safety and immunogenicity of a measles, mumps, rubella and varicella vaccine given with combined Haemophilus influenzae type b conjugate/hepatitis B vaccines and combined diphtheria-tetanus-acellular pertussis vaccines. causal interaction,diagnostic usage,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16569347&form=6&db=m Soluble CD30 and lymphocyte activation gene-3 (CD223), as potential serological markers of T helper-type cytokine response induced by acellular pertussis vaccine. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16572239&form=6&db=m Immunogenicity and reactogenicity of a reduced-antigen-content diphtheria-tetanus-acellular pertussis vaccine as a single-dose booster in Singaporean adults. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16574906&form=6&db=m Endostatin, the proteolytic fragment of collagen XVIII, induces vasorelaxation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16594997&form=6&db=m Interleukin 1b and anaphylatoxins exert a synergistic effect on NGF expression by astrocytes. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16595906&form=6&db=m Different pathways for activation of extracellular signal-regulated kinase through thromboxane A2 receptor isoforms. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16598657&form=6&db=m Influence of pertussis toxin on CD1a isoform expression in human dendritic cells. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16600218&form=6&db=m Trichinella spiralis: histamine secretion induced by TSL-1 antigens from unsensitized mast cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16601090&form=6&db=m Mast cell migration to Th2 stimulated airway smooth muscle from asthmatics. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16602827&form=6&db=m Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16607854&form=6&db=m [Functional characteristics of nucleotide-receptors in human neutrophils] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16614393&form=6&db=m Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAPK. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16615994&form=6&db=m Tumor necrosis factor-alpha inhibits the cardiac delayed rectifier K current via the asphingomyelin pathway. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16616768&form=6&db=m Lysophospholipids elevate [Ca2+]i and trigger exocytosis in bovine chromaffin cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16617115&form=6&db=m ADP-ribosylating and vacuolating cytotoxin of Mycoplasma pneumoniae represents unique virulence determinant among bacterial pathogens. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16617351&form=6&db=m [Chemotactic and mitogenic effect of rat chemokine-like factor 1 on aortic smooth muscle cells.] ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16622017&form=6&db=m Loss of dendritic cell migration and impaired resistance to Leishmania donovani infection in mice deficient in CCL19 and CCL21. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16622226&form=6&db=m Signal transduction mechanism involved in Clostridium perfringens alpha-toxin-induced superoxide anion generation in rabbit neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16630612&form=6&db=m Phospholipase D from photoreceptor rod outer segments is a downstream effector of RhoA: evidence of a light-dependent mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16631594&form=6&db=m Stimulation of cyclic AMP production by the Caenorhabditis elegans muscarinic acetylcholine receptor GAR-3 in Chinese hamster ovary cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16631628&form=6&db=m Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16632463&form=6&db=m Expression of melatoninergic receptors in human placental choriocarcinoma cell lines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16635021&form=6&db=m Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16636104&form=6&db=m Granzyme B mediates neurotoxicity through a G-protein-coupled receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16638808&form=6&db=m Toxoplasma gondii triggers Gi-dependent PI 3-kinase signaling required for inhibition of host cell apoptosis. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16641381&form=6&db=m Dopamine presynaptically depresses fast inhibitory synaptic transmission via D4 receptor-protein kinase A pathway in the rat dorsolateral septal nucleus. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16644903&form=6&db=m Pharmacological and molecular characterization of the mechanisms involved in prostaglandin E2-induced mouse paw edema. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16647694&form=6&db=m Regulation of expression of early growth response transcription factors in rat primary cortical neurons by extracellular ATP. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16650405&form=6&db=m Histamine release, an undesired effect of thrombin inhibitors with basic character, is mediated through direct activation of G(i) proteins. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16652167&form=6&db=m Purinergic receptors activating rapid intracellular Ca increases in microglia. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16652423&form=6&db=m Characterization of an activation factor released from human neutrophils after stimulation by triclinic monosodium urate crystals. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16670126&form=6&db=m Induction of human neutrophil chemotaxis by Candida albicans-derived beta-1,6-long glycoside side-chain-branched beta-glucan. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16672224&form=6&db=m Casein kinase 2 Is activated and essential for Wnt/beta-catenin signaling. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16674917&form=6&db=m Sphingosine-1-phosphate stimulates rat primary chondrocyte proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16686682&form=6&db=m Molecular control of cardiac sodium homeostasis in health and disease. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16688466&form=6&db=m Dinucleoside polyphosphates and their interaction with other nucleotide signaling pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16688761&form=6&db=m Dopamine regulates cell cycle regulatory proteins via cAMP, Ca(2+)/PKC, MAPKs, and NF-kappaB in mouse embryonic stem cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16689799&form=6&db=m Genetic exchange of the S2 and S3 subunits in pertussis toxin. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16690000&form=6&db=m The seroepidemiology of pertussis in Australia during an epidemic period. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16690053&form=6&db=m Mast cell chymase induces expression of chemokines for neutrophils in eosinophilic EoL-1 cells and mouse peritonitis eosinophils. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16699066&form=6&db=m Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: The effects of subtype-selective agonists and the role of G-protein-mediated signaling. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16699568&form=6&db=m Expression of a pertussis toxin S1 fragment by inducible promoters in oral Streptococcus and the induction of immune responses during oral colonization in mice. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16707501&form=6&db=m A novel role for protein phosphatase 2A in receptor-mediated regulation of the cardiac sarcolemmal Na+/H+ exchanger NHE1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16709961&form=6&db=m Adenosine A1 receptors mediate mobilization of calcium in human bronchial smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16712979&form=6&db=m Role of NPR-C natriuretic receptor in nitric oxide system activation induced by atrial natriuretic peptide. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16713658&form=6&db=m The CART receptors: background and recent advances. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16714209&form=6&db=m Modulation of neutrophil apoptosis by beta-amyloid proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16716807&form=6&db=m Differences in CXCR4-mediated signaling in B cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16720313&form=6&db=m Gi proteins regulate lipopolysaccharide and Staphylococcus aureus induced cytokine production but not (1--> 3)-beta-D-glucan induced cytokine suppression. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16723377&form=6&db=m Cooperative mitogenic signaling by G protein-coupled receptors and growth factors is dependent on G(q/11). therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16725167&form=6&db=m Dehydroepiandrosterone inhibits intracellular calcium release in beta-cells by a plasma membrane-dependent mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16725215&form=6&db=m The chromogranin A peptide vasostatin-I inhibits gap formation and signal transduction mediated by inflammatory agents in cultured bovine pulmonary and coronary arterial endothelial cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16731654&form=6&db=m Cardioprotective effects of acute and chronic opioid treatment are mediated via different signaling pathways. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16733230&form=6&db=m Insulin-stimulated NADH/NAD+ redox state increases NAD(P)H oxidase activity in cultured rat vascular smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16740995&form=6&db=m Endothelin 1 stimulates beta1Pix-dependent activation of Cdc42 through the G(salpha) pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16750574&form=6&db=m Altered subcellular signaling in murine peritoneal macrophages upon chronic morphine exposure. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16751412&form=6&db=m TLR2 transmodulates monocyte adhesion and transmigration via Rac1- and PI3K-mediated inside-out signaling in response to Porphyromonas gingivalis fimbriae. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16754668&form=6&db=m Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16755471&form=6&db=m Measures to control an outbreak of pertussis in a neonatal intermediate care nursery after exposure to a healthcare worker. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16757729&form=6&db=m Aldosterone inhibits apical NHE3 and HCO3- absorption via a nongenomic ERK-dependent pathway in medullary thick ascending limb. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16759914&form=6&db=m Pseudopterosin A inhibits phagocytosis and alters intracellular calcium turnover in a pertussis toxin sensitive site in Tetrahymena thermophila. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16760261&form=6&db=m Lysophosphatidic acid as a mediator for proinflammatory agonists in a human corneal epithelial cell line. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16760337&form=6&db=m Adrenomedullin inhibits insulin exocytosis via pertussis toxin-sensitive G protein-coupled mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16769764&form=6&db=m IL-6 and IL-8 release is mediated via multiple signaling pathways after stimulating dendritic cells with lysophospholipids. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16777973&form=6&db=m The endocrine-disrupting compound, nonylphenol, inhibits neurotrophin-dependent neurite outgrowth. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778131&form=6&db=m Selective activation of nuclear phospholipase D-1 by g protein-coupled receptor agonists in vascular smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16779740&form=6&db=m Bordetella Pertussis infections in vaccinated and unvaccinated adolescents and adults, as assessed in a national prospective randomized Acellular Pertussis Vaccine Trial (APERT). causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16782039&form=6&db=m Development of a carbohydrate binding assay for the B-oligomer of pertussis toxin and toxoid. causal interaction,diagnostic usage,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16783847&form=6&db=m Pertussis toxin activates adult and neonatal naive human CD4+ T lymphocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16791011&form=6&db=m The efficiency of R5 HIV-1 infection is determined by CD4 T-cell surface CCR5 density through G alpha i-protein signalling. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16793752&form=6&db=m Expression of GTP-binding proteins and protein kinase C isozymes in platelet-like particles derived from megakaryoblastic leukemia cells (MEG-01). ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16794003&form=6&db=m Sphingosine 1-phosphate affects cytokine-induced apoptosis in rat pancreatic islet beta-cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16802354&form=6&db=m Effects of interleukin-1 on calcium signaling and the increase of filamentous actin in isolated and in situ articular chondrocytes. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16803866&form=6&db=m Insulin-like growth factor-I induces alpha(1B)-adrenergic receptor phosphorylation through G beta gamma and epidermal growth factor receptor transactivation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16804322&form=6&db=m A neuroactive steroid inhibits guinea pig airway sensory nerves via Maxi-K channel activation. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16805920&form=6&db=m Nongenomic oestrogen signalling in oestrogen receptor negative breast cancer cells: a role for the angiotensin II receptor AT1. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16820147&form=6&db=m Functional expression of the P2Y14 receptor in human neutrophils. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16823926&form=6&db=m Attenuated Bordetella pertussis: new live vaccines for intranasal immunisation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16824805&form=6&db=m Loss of vascular adenosine A1 receptors with age in the rat heart. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16825187&form=6&db=m Essential role of G protein-gated inwardly rectifying potassium channels in gonadotropin-induced regulation of GnRH neuronal firing and pulsatile neurosecretion. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16828169&form=6&db=m Retinal ganglion cell damage induced by spontaneous autoimmune optic neuritis in MOG-specific TCR transgenic mice. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16828564&form=6&db=m Inhibition of T cell homing by down-regulation of CD62L and the induction of a Th-2 response as a method to prevent acute allograft rejection in mice. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16829628&form=6&db=m Functional expression of the GABAB receptor in human airway smooth muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16830591&form=6&db=m [Humoral imunity to pertussis in children with diabetes of type 1] diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16836650&form=6&db=m Essential role of neutrophils in anti-type II collagen antibody and lipopolysaccharide-induced arthritis. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16839714&form=6&db=m Characterization of Bordetella bronchiseptica strains using phenotypic and genotypic markers. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16840783&form=6&db=m The isoflavone Equol mediates rapid vascular relaxation: Ca2+-independent activation of endothelial nitric-oxide synthase/Hsp90 involving ERK1/2 and Akt phosphorylation in human endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16843602&form=6&db=m Presynaptic inhibition of spontaneous acetylcholine release mediated by P2Y receptors at the mouse neuromuscular junction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16845387&form=6&db=m G(o) signaling is required for Drosophila associative learning. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16846786&form=6&db=m Lysophosphatidic acid cooperates with 1alpha,25(OH)2D3 in stimulating human MG63 osteoblast maturation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16849427&form=6&db=m The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16849462&form=6&db=m Pertussis toxin reduces the number of splenic Foxp3+ regulatory T cells. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16849470&form=6&db=m Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16850528&form=6&db=m Crosstalk of sterol-dependent and non-sterol-dependent signaling in human monocytes after in vitro addition of LDL. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16855922&form=6&db=m Seroprevalence of IgG antibodies to pertussis toxin in the Slovene population. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16863917&form=6&db=m The chemokine CXCL14 (BRAK) stimulates activated NK cell migration: implications for the downregulation of CXCL14 in malignancy. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16863919&form=6&db=m Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16876782&form=6&db=m Estrogen modulates in vitro atrial bradycardia induced by Indian red scorpion venom via G-protein coupled mechanisms. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16877527&form=6&db=m Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16877565&form=6&db=m Fractalkine stimulates angiogenesis by activating the Raf-1/MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16879222&form=6&db=m The complement component C5a induces the expression of plasminogen activator inhibitor-1 in human macrophages via NF-kappaB activation. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16879804&form=6&db=m Desensitization of somatostatin-induced inhibition of low extracellular magnesium concentration-induced calcium spikes in cultured rat hippocampal neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16885213&form=6&db=m Activation of heterotrimeric G proteins by Smoothened. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16887331&form=6&db=m Short-chain fatty acids induce acute phosphorylation of the p38 mitogen-activated protein kinase/heat shock protein 27 pathway via GPR43 in the MCF-7 human breast cancer cell line. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16888186&form=6&db=m Mechanisms and modulation of pituitary adenylate cyclase-activating protein-induced calcium mobilization in human neutrophils. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16889750&form=6&db=m Leukotriene B4 stimulates human monocyte-derived dendritic cell chemotaxis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16893572&form=6&db=m Diversified serum IgG response involving non-myelin CNS proteins during experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16899559&form=6&db=m Cell-surface expression, progestin binding, and rapid nongenomic signaling of zebrafish membrane progestin receptors alpha and beta in transfected cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16899767&form=6&db=m Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16901923&form=6&db=m Characterization of ghrelin receptor activity in a rat pituitary cell line RC-4B/C. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16902194&form=6&db=m Muscarinic receptors mediate stimulation of human lung fibroblast proliferation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16904145&form=6&db=m Depression of cardiac L-type calcium current by a scorpion venom fraction M1 following muscarinic receptors interaction involving adenylate cyclase pathway. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16914291&form=6&db=m The neuropeptide pituitary adenylate cyclase activating protein stimulates human monocytes by transactivation of the Trk/NGF pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16914652&form=6&db=m Detection of anti-pertussis toxin IgG in oral fluids for use in diagnosis and surveillance of Bordetella pertussis infection in children and young adults. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16914897&form=6&db=m P2Y receptors activate MAPK/ERK through a pathway involving PI3K/PDK1/PKC-zeta in human vein endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16917518&form=6&db=m Molecular characterization of a G protein alpha-subunit-encoding gene from Mucor circinelloides. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16920709&form=6&db=m Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16920908&form=6&db=m Cutting edge: Interleukin 4-dependent mast cell proliferation requires autocrine/intracrine cysteinyl leukotriene-induced signaling. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16926156&form=6&db=m Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16930443&form=6&db=m Peripheral antinociceptive effect of pertussis toxin: activation of the arginine/NO/cGMP/PKG/ ATP-sensitive K channel pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16931866&form=6&db=m S100A8 Triggers Oxidation-sensitive Repulsion of Neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16934753&form=6&db=m Mechanism of isoproterenol-induced RGS2 up-regulation in astrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16935853&form=6&db=m Identification of a protein hydrolysate responsive G protein-coupled receptor in enterocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16940740&form=6&db=m Prostaglandin D(2) Induces IL-8 and GM-CSF by Bronchial Epithelial Cells in a CRTH2-Independent Pathway. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16942596&form=6&db=m Biochemical and functional characterization of high-affinity urotensin II receptors in rat cortical astrocytes. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16946718&form=6&db=m Extracellular ATP has stimulatory effects on the expression and release of IL-6 via purinergic receptors in normal human epidermal keratinocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16949564&form=6&db=m Meiotic resumption in response to luteinizing hormone is independent of a Gi family G protein or calcium in the mouse oocyte. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16950635&form=6&db=m Expression and purification of a trivalent pertussis toxin-diphtheria toxin-tetanus toxin fusion protein in Escherichia coli. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16953191&form=6&db=m An M2-like muscarinic receptor enhances a delayed rectifier K+ current in rat sympathetic neurones. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16956604&form=6&db=m Activation of adenosine A(1) receptor modulates dopamine D(1) receptor activity in stably cotransfected human embryonic kidney 293 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16960020&form=6&db=m Effect of age on vascular beta2-adrenergic receptor desensitization is not mediated by the receptor coupling to Galphai proteins. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16962210&form=6&db=m Involvement of G-protein betagamma subunits on the influence of inhibitory alpha2-autoreceptors on the angiotensin AT1-receptor modulation of noradrenaline release in the rat vas deferens. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16967873&form=6&db=m [Mechanism of carbachol and adenosine action on spontaneous quantal mediator release at frog neuromuscular junction] therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16970675&form=6&db=m Experimental Autoimmune Encephalomyelitis Develops in CC Chemokine Receptor 7-deficient Mice with Altered T-cell Responses. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16972265&form=6&db=m Signaling networks from Gbeta1 subunit to transcription factors and actin remodeling via a membrane-located ERbeta-related protein in the rapid action of daidzein in osteoblasts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16973728&form=6&db=m Sphingosine-1-phosphate modulates both lipolysis and leptin production in differentiated rat white adipocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16973919&form=6&db=m Atrial natriuretic factor negatively modulates secretin intracellular signaling in the exocrine pancreas. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16978909&form=6&db=m G protein beta2 subunit interacts directly with neuropathy target esterase and regulates its activity. diagnostic usage,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16982748&form=6&db=m Extracellular calcium as a candidate mediator of prostate cancer skeletal metastasis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16982873&form=6&db=m Induction of Autoimmunity by Expansion of Autoreactive CD4+CD62Llow Cells In Vivo. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16984416&form=6&db=m Induction of dendritic cell migration upon Toxoplasma gondii infection potentiates parasite dissemination. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16990586&form=6&db=m Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16997880&form=6&db=m Oxygen alters caveolin-1 and nitric oxide synthase-3 functions in ovine fetal and neonatal lung microvascular endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16997967&form=6&db=m YtxR, a conserved LysR-like regulator that induces expression of genes encoding a putative ADP-ribosyltransferase toxin homologue in Yersinia enterocolitica. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17002784&form=6&db=m Pertussis toxin transiently affects barrier integrity, organelle organization and transmigration of monocytes in a human brain microvascular endothelial cell barrier model. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17003950&form=6&db=m Bradykinin-induced chloride conductance in murine proximal tubule epithelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17007821&form=6&db=m R-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)-pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphtalenylmethanone (WIN-2) ameliorates experimental autoimmune encephalomyelitis and induces encephalitogenic T cell apoptosis: partial involvement of the CB(2) receptor. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17008551&form=6&db=m The extracellular nucleotide UTP is a potent inducer of hematopoietic stem cell migration. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17011156&form=6&db=m Inverse regulation of leptin mRNA expression by short- and long-chain fatty acids in cultured bovine adipocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17014689&form=6&db=m Modulation of melatonin receptors and G-protein function by microtubules. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17015637&form=6&db=m Mechanisms linking adenosine A1 receptors and extracellular signal-regulated kinase 1/2 activation in human trabecular meshwork cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17016846&form=6&db=m Latrophilin-2 is a novel component of the epithelial-mesenchymal transition within the atrioventricular canal of the embryonic chicken heart. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17018691&form=6&db=m A comparison of the antagonist affinities for the Gi- and Gs-coupled states of the human adenosine A1-receptor. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17023430&form=6&db=m Lysophospholipids control integrin-dependent adhesion in splenic B cells through G(i) and G(12)/G(13) family G-proteins but not through G(q)/G(11). causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17023506&form=6&db=m Muscarinic acetylcholine receptor knockout mice show distinct synaptic plasticity impairments in the visual cortex. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17027043&form=6&db=m Pre-synaptic histamine H3 receptors regulate glutamate, but not GABA release in rat thalamus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17030495&form=6&db=m Population dynamics of Bordetella pertussis in Finland and Sweden, neighbouring countries with different vaccination histories. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17030663&form=6&db=m Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17031069&form=6&db=m Pharmacological profiles of the novel analgesic M58996 in rat models of persistent and neuropathic pain. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17035041&form=6&db=m NANC inhibitory neuromuscular transmission in the hamster distal colon. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17035533&form=6&db=m Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17038637&form=6&db=m Apolipoprotein CIII-induced THP-1 cell adhesion to endothelial cells involves pertussis toxin-sensitive G protein- and protein kinase C alpha-mediated nuclear factor-kappaB activation. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17038640&form=6&db=m Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17044040&form=6&db=m Prosaposin upregulates AR and PSA expression and activity in prostate cancer cells (LNCaP). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17046831&form=6&db=m Role of scavenger receptor class B type I and sphingosine 1-phosphate receptors in high density lipoprotein-induced inhibition of adhesion molecule expression in endothelial cells. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17047412&form=6&db=m The effects of phorbol 12-myristate 13-acetate, cholera toxin, prostaglandin E2 and norepinephrine on inducible nitric oxide synthase activation induced by lipopolysaccharide in C6 cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17049126&form=6&db=m Granulocyte-macrophage colony-stimulating factor DNA prime-protein boost strategy to enhance efficacy of a recombinant pertussis DNA vaccine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17050047&form=6&db=m Development of safer pertussis DNA vaccine expressing non-toxic C180 polypeptide of pertussis toxin S1 subunit. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17050831&form=6&db=m Regulation of glutamate release from primary afferents and interneurons in the spinal cord by muscarinic receptor subtypes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17056154&form=6&db=m Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-G(i/o) pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17056574&form=6&db=m 5-hydroxytryptamine induces mast cell adhesion and migration. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17056591&form=6&db=m The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17065365&form=6&db=m Comparison of signaling pathways activated by the relaxin family peptide receptors, RXFP1 and RXFP2, using reporter genes. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17067316&form=6&db=m Distinct roles of Ca2+ mobilization and G protein usage on regulation of Toll-like receptor function in human and murine mast cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17068477&form=6&db=m Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17073145&form=6&db=m Molecular mechanisms for the effect of mastoparan on G proteins in tissues of vertebrates and invertebrates. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17080352&form=6&db=m [Can the determination of IgG antibodies to the pertussis toxin help the diagnosis of the disease?] diagnostic usage,ongoing research,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17082604&form=6&db=m Pertussis toxin is superior to TLR ligands in enhancing pathogenic autoimmunity, targeted at a neo-self antigen, by triggering robust expansion of Th1 cells and their cytokine production. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17082642&form=6&db=m Metalloproteinases control brain inflammation induced by pertussis toxin in mice overexpressing the chemokine CCL2 in the central nervous system. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17083039&form=6&db=m Pertussis toxin and its binding unit inhibit HIV-1 infection of human cervical tissue and macrophages involving a CD14 pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17093123&form=6&db=m Adenosine inhibits activity of hypocretin/orexin neurons by the A1 receptor in the lateral hypothalamus: a possible sleep-promoting effect. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17099717&form=6&db=m Roles of M2 and M3 muscarinic receptors in cholinergic nerve-induced contractions in mouse ileum studied with receptor knockout mice. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17101228&form=6&db=m Critical role of methionine-722 in the stimulation of human brain G-proteins and neurotoxicity induced by London familial Alzheimer's disease (FAD) mutated V717G-APP(714-723). causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17105192&form=6&db=m The pertussis toxin S1 subunit is a thermally unstable protein susceptible to degradation by the 20S proteasome. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17105765&form=6&db=m Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-beta-dependent mechanism. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17105828&form=6&db=m Sphingosine 1-phosphate causes airway hyper-reactivity by rho-mediated myosin phosphatase inactivation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17107942&form=6&db=m Extracellular signal-regulated kinase activation by parathyroid hormone in distal tubule cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17108089&form=6&db=m Increased nociceptive input rapidly modulates spinal GABAergic transmission through endogenously released glutamate. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17110384&form=6&db=m Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17111362&form=6&db=m PECAM-1 modulates thrombin-induced tissue factor expression on endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17114429&form=6&db=m The chemokine CX3CL1 reduces migration and increases adhesion of neurons with mechanisms dependent on the beta1 integrin subunit. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17114809&form=6&db=m Tumor necrosis factor-alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent Akt activation and cyclin D expression. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17116347&form=6&db=m Modulation of the infant immune responses by the first pertussis vaccine administrations. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17118010&form=6&db=m Activator of G-protein signaling in asymmetric cell divisions of the sea urchin embryo. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17119919&form=6&db=m Beta(2)-Adrenergic activation increases glycogen synthesis in L6 skeletal muscle cells through a signalling pathway independent of cyclic AMP. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17124637&form=6&db=m Human epidermoid A431 cells express functional nicotinic acid receptor HM74a. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17126295&form=6&db=m Selenazoles (selenium compounds) facilitate survival of cultured rat pheochromocytoma PC12 cells after serum-deprivation and stimulate their neuronal differentiation via activation of Akt and mitogen-activated protein kinase, respectively. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17126321&form=6&db=m kappa-opioid receptor stimulation inhibits cardiac hypertrophy induced by beta1-adrenoceptor stimulation in the rat. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17127411&form=6&db=m Aberrant Gi protein coupled receptor-mediated cell survival signaling in rheumatoid arthritis B cell lines. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17130674&form=6&db=m Contribution of extracellular signal-regulated kinase to UTP-induced interleukin-6 biosynthesis in HaCaT keratinocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17135293&form=6&db=m A chemoattractant-mediated Gi-coupled pathway activates adenylyl cyclase in human neutrophils. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17138670&form=6&db=m GABA and Gi/o differentially control circadian rhythms and synchrony in clock neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17142685&form=6&db=m Beta3-adrenoceptor in the eel (Anguilla anguilla) heart: negative inotropy and NO-cGMP-dependent mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17146562&form=6&db=m Adenosine A1 receptor-mediated inhibition of in vitro prolactin secretion from the rat anterior pituitary. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17151210&form=6&db=m Multitarget PCR for diagnosis of pertussis and its clinical implications. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17151221&form=6&db=m Modulation of Ca2+ channels by heterologously expressed wild-type and mutant human micro-opioid receptors (hMORs) containing the A118G single-nucleotide polymorphism. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17154364&form=6&db=m Chemotactic peptide fMetLeuPhe induces translocation of the TRPV2 channel in macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17157326&form=6&db=m Characteristics of lysophosphatidylcholine-induced Ca2+ response in human neuroblastoma SH-SY5Y cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17161826&form=6&db=m Effect of lysophosphatidylglycerol on several signaling molecules in OVCAR-3 human ovarian cancer cells: involvement of pertussis toxin-sensitive G-protein coupled receptor. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17162379&form=6&db=m HIV-1 Tat triggers TGF-beta production and NK cell apoptosis that is prevented by pertussis toxin B. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17167784&form=6&db=m Dopamine stimulates 45Ca2+ uptake through cAMP, PLC/PKC, and MAPKs in renal proximal tubule cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17169446&form=6&db=m Cross-regulation of VPAC2 receptor internalization by m2 receptors via c-Src-mediated phosphorylation of GRK2. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17175038&form=6&db=m Parallel inactivation of Y2 receptor and G-proteins in CHO cells by pertussis toxin. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17175059&form=6&db=m Interleukin-8 stimulates cell proliferation in non-small cell lung cancer through epidermal growth factor receptor transactivation. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17176262&form=6&db=m Molecular cloning of prostaglandin EP3 receptors from canine sensory ganglia and their facilitatory action on bradykinin-induced mobilization of intracellular calcium. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17179660&form=6&db=m Protective immunity against Bordetella pertussis by a recombinant DNA vaccine and the effect of coinjection with a granulocyte-macrophage colony stimulating factor gene. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17179741&form=6&db=m Activation of serum response element by D2 dopamine receptor is governed by Gbetagamma-mediated MAPK and Rho pathways and regulated by RGS proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17184585&form=6&db=m Serum amyloid A induces WISH cell apoptosis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17186496&form=6&db=m Obestatin-mediated proliferation of human retinal pigment epithelial cells: regulatory mechanisms. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17188372&form=6&db=m Melanocortin-3 receptor activates MAP kinase via PI3 kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17192598&form=6&db=m Acrosome reaction induced by recombinant human zona pellucida 3 peptides rhuZP3a22 approximately 176 and rhuZP3b177 approximately 348 and their mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17200418&form=6&db=m Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17201734&form=6&db=m Effect of alpha-adrenoceptor subtype-selective inverse agonists on non-pregnant and late-pregnant cervical resistance in vitro in the rat. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17204501&form=6&db=m C-type natriuretic peptide activates a non-selective cation current in acutely isolated rat cardiac fibroblasts via natriuretic peptide C receptor-mediated signalling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17229082&form=6&db=m Urinary pheromones promote ERK/Akt phosphorylation, regeneration and survival of vomeronasal (V2R) neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17229869&form=6&db=m High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl peptide receptor agonists. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17230440&form=6&db=m Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17230639&form=6&db=m Mediation of adenylyl cyclase sensitization by PTX-insensitive GalphaoA, Galphai1, Galphai2 or Galphai3. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17234990&form=6&db=m Functional expression of N-formyl peptide receptors in human bone marrow-derived mesenchymal stem cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17237247&form=6&db=m Role of lipoprotein-associated lysophospholipids in migratory activity of coronary artery smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17242062&form=6&db=m Pertussis toxin targets airway macrophages to promote Bordetella pertussis infection of the respiratory tract. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17244681&form=6&db=m Antiendothelial cell antibodies mediate enhanced leukocyte adhesion to cytokine-activated endothelial cells through a novel mechanism requiring cooperation between Fc{gamma}RIIa and CXCR1/2. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17255471&form=6&db=m Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17257496&form=6&db=m Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17266783&form=6&db=m G protein coupling profile of mGluR6 and expression of G alpha proteins in retinal ON bipolar cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17267583&form=6&db=m Effects of cannabinoids on synaptic transmission in the frog neuromuscular junction. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17267589&form=6&db=m Cellular immunity in adolescents and adults following acellular pertussis vaccine administration. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17267663&form=6&db=m Real-time analysis of agonist-induced activation of protease-activated receptor 1/Galphai1 protein complex measured by bioluminescence resonance energy transfer in living cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17277048&form=6&db=m Raf-1 kinase mediates adenylyl cyclase sensitization by TNF-alpha in human airway smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17279313&form=6&db=m Cellular internalization of proinsulin C-peptide. causal interaction,diagnostic usage,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17280478&form=6&db=m Acellular pertussis vaccines and the role of pertactin and fimbriae. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17283075&form=6&db=m Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17283239&form=6&db=m The possible mechanisms by which phanoside stimulates insulin secretion from rat islets. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17284532&form=6&db=m Adoptive transfer of tumor-primed, in vitro-activated, CD4+ T effector cells (TEs) combined with CD8+ TEs provides intratumoral TE proliferation and synergistic antitumor response. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17287049&form=6&db=m ADP-ribosylation activity in pertussis vaccines and its relationship to the in vivo histamine-sensitisation test. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17287216&form=6&db=m Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17287434&form=6&db=m Signaling mechanisms of angiotensin II-induced attenuation of GABAergic input to hypothalamic presympathetic neurons. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17289675&form=6&db=m Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17291636&form=6&db=m The rise in pertussis cases urges replacement of chemically-inactivated with genetically-inactivated toxoid for DTP. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17292352&form=6&db=m 2-Arachidonylglyceryl ether and abnormal cannabidiol-induced vascular smooth muscle relaxation in rabbit pulmonary arteries via receptor-pertussis toxin sensitive G proteins-ERK1/2 signaling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17293559&form=6&db=m Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17300916&form=6&db=m Regulator of G-protein signalling 3 redirects prototypical Gi-coupled receptors from Rac1 to RhoA activation. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17301432&form=6&db=m Induction of Experimental Allergic Encephalomyelitis in C57/BL6 Mice: An Animal Model for Multiple Sclerosis, Hossein Mostafavi, and Bahman Zeynali. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17306234&form=6&db=m Abeta peptides can enter the brain through a defective blood-brain barrier and bind selectively to neurons. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17310098&form=6&db=m Stimulatory pathways of the Calcium-sensing receptor on acid secretion in freshly isolated human gastric glands. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17314286&form=6&db=m Dominant role of betagamma subunits of G-proteins in oxytocin-evoked burst firing. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17320845&form=6&db=m Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17329257&form=6&db=m Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17331965&form=6&db=m Idiopathic pulmonary fibrosis fibroblasts migrate and proliferate to CC chemokine ligand 21. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17332478&form=6&db=m Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17332693&form=6&db=m Mechanism of Na+/Ca2+ exchanger activation by hydrogen peroxide in guinea-pig ventricular myocytes. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17339350&form=6&db=m Requirements for assembly of PtlH with the pertussis toxin transporter apparatus of Bordetella pertussis. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17345793&form=6&db=m Inhibition of inward rectifier K+ currents by angiotensin II in rat atrial myocytes: lack of effects in cells from spontaneously hypertensive rats. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17349972&form=6&db=m S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17360805&form=6&db=m Differential effects of G protein coupled receptors on hematopoietic progenitor cell growth depend on their signaling capacities. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17363269&form=6&db=m Highly sensitive histamine-sensitization test for residual activity of pertussis toxin in acellular pertussis vaccine. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17366007&form=6&db=m Pertussis seroprevalence in different age groups in Greece. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17368618&form=6&db=m The enhancement of dopamine D1 receptor desensitization by adenosine A1 receptor activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369456&form=6&db=m A novel signaling pathway for beta-adrenergic receptor-mediated activation of phosphoinositide 3-kinase in H9c2 cardiomyocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17374154&form=6&db=m Sphingosine-1-phosphate attenuates proteoglycan aggrecan expression via production of prostaglandin E2 from human articular chondrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17379261&form=6&db=m Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17379772&form=6&db=m Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17382352&form=6&db=m Sphingosine 1-phosphate induces cyclooxygenase-2 via Ca2+-dependent, but MAPK-independent mechanism in rat vascular smooth muscle cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17384686&form=6&db=m Galanin and galanin receptor type 1 suppress proliferation in squamous carcinoma cells: activation of the extracellular signal regulated kinase pathway and induction of cyclin-dependent kinase inhibitors. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17389374&form=6&db=m Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17392404&form=6&db=m Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17392688&form=6&db=m Control of PDGF-induced reactive oxygen species (ROS) generation and signal transduction in human lens epithelial cells. diagnostic usage,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17395174&form=6&db=m The role of Gi proteins in reduced vasorelaxation response to beta-adrenoceptor agonists in rat aorta during maturation. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17395704&form=6&db=m Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Galphai protein-dependent activation of phosphatidylinositol 3-kinase/Akt and regulation of antiapoptotic Bcl-2 expression. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17395890&form=6&db=m Alpha1-antitrypsin suppresses TNF-alpha and MMP-12 production by cigarette smoke-stimulated macrophages. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17400722&form=6&db=m Possible roles of neuropeptide Y Y3-receptor subtype in rat aortic endothelial cell proliferation under hypoxia, and its specific signal transduction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17416598&form=6&db=m Human recombinant chromogranin A-derived vasostatin-1 mimics preconditioning via an adenosine/nitric oxide signaling mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17418103&form=6&db=m Lysophosphatidic acid induces osteocyte dendrite outgrowth. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17419758&form=6&db=m Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17420233&form=6&db=m Evading the proteasome: absence of lysine residues contributes to pertussis toxin activity by evasion of proteasome degradation. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17420241&form=6&db=m Role of D-alanylation of Streptococcus gordonii lipoteichoic acid in innate and adaptive immunity. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17437547&form=6&db=m Involvement of KCNQ2 subunits in [3H]dopamine release triggered by depolarization and pre-synaptic muscarinic receptor activation from rat striatal synaptosomes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17438360&form=6&db=m The anti-apoptotic activity of albumin for endothelium is mediated by a partially cryptic protein domain and reduced by inhibitors of G-coupled protein and PI-3 kinase, but is independent of radical scavenging or bound lipid. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17439946&form=6&db=m A novel regulatory role for stromal-derived factor-1 signaling in bone morphogenic protein-2 osteogenic differentiation of mesenchymal C2C12 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17441793&form=6&db=m Codeine induces human mast cell chemokine and cytokine production: involvement of G-protein activation. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17442310&form=6&db=m Expression and functional role of formyl peptide receptor in human bone marrow-derived mesenchymal stem cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17443462&form=6&db=m Immunity to pertussis 5 years after booster immunization during adolescence. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17447474&form=6&db=m [The risk of pertussis and diphtheria infections among pediatric healthcare workers in Japan] causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17449940&form=6&db=m Sphingosine 1-phosphate triggers apoptotic signal for B16 melanoma cells via ERK and caspase activation. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17454165&form=6&db=m Non-genomic effects of 17beta-estradiol in activation of the ERK1/ERK2 pathway induces cell proliferation through upregulation of cyclin D1 expression in bovine artery endothelial cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17464180&form=6&db=m Phytosphingosine-1-phosphate stimulates chemotactic migration of L2071 mouse fibroblasts via pertussis toxin-sensitive G-proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17464763&form=6&db=m Formyl peptide receptor expression in birds. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17467689&form=6&db=m Antinociceptive action of myricitrin: involvement of the K+ and Ca2+ channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17474866&form=6&db=m Dietary fish oil deactivates a growth-promoting signaling pathway in hepatoma 7288CTC in Buffalo rats. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17475445&form=6&db=m Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P1 receptor. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17475838&form=6&db=m Pertussis toxin by inducing IL-6 promotes the generation of IL-17-producing CD4 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17475884&form=6&db=m Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17485513&form=6&db=m CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase-independent manner. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17493917&form=6&db=m Modulation of a delayed-rectifier K+ current by angiotensin II in rat sympathetic neurons. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17494865&form=6&db=m Distinct Ca2+ requirement for NO production between proteinase-activated receptor 1 and 4 (PAR1 and PAR4) in vascular endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17499746&form=6&db=m Dioleoyl phosphatidic acid increases intracellular Ca2+ through endogenous LPA receptors in C6 glioma and L2071 fibroblasts. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17504296&form=6&db=m Changes of the Swedish Bordetella pertussis population in incidence peaks during an acellular pertussis vaccine period between 1997 and 2004. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17507542&form=6&db=m Opsonophagocytic activity and other serological indications of Bordetella pertussis infection in military recruits in Norway. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17521884&form=6&db=m Pertussis toxin promotes macrophage survival through inhibition of acid sphingomyelinase and activation of the phosphoinositide 3-kinase/protein kinase B pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17525234&form=6&db=m Chemotaxis and differentiation of human adipose tissue CD34+/CD31- progenitor cells: role of stromal derived factor-1 released by adipose tissue capillary endothelial cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17535904&form=6&db=m Receptor-mediated activation of nitric oxide synthesis by arginine in endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17543300&form=6&db=m Involvement of chemical mediators in nasal allergic responses of HDC-KO mice. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17543554&form=6&db=m Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17546512&form=6&db=m The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17548612&form=6&db=m Requirements for T lymphocyte migration in explanted lymph nodes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17548656&form=6&db=m IFN-gamma-induced chemokines synergize with pertussis toxin to promote T cell entry to the central nervous system. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17558435&form=6&db=m Virodhamine and CP55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17559171&form=6&db=m House dust mite allergen activates human eosinophils via formyl peptide receptor and formyl peptide receptor-like 1. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17562543&form=6&db=m The receptor attributable to C-type natriuretic peptide-induced differentiation of osteoblasts is switched from type B- to type C-natriuretic peptide receptor with aging. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17562776&form=6&db=m Pertussis toxin utilizes proximal components of the T-cell receptor complex to initiate signal transduction events in T cells. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17566274&form=6&db=m Structural and functional attributes of zona pellucida glycoproteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17566285&form=6&db=m Novel gamete receptors that facilitate sperm adhesion to the egg coat. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17567799&form=6&db=m Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17574041&form=6&db=m Mechanisms of kringle fragment of urokinase-induced vascular smooth muscle cell migration. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17575083&form=6&db=m Ghrelin uses Galphai2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet beta-cells: novel signal transduction of ghrelin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581194&form=6&db=m PAR-2 activation regulates IL-8 and GRO-alpha synthesis by NF-kappaB, but not RANTES, IL-6, eotaxin or TARC expression in nasal epithelium. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581202&form=6&db=m Leukotriene B(4) enhances tumour necrosis factor-alpha-induced CCL27 production in human keratinocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581302&form=6&db=m D2 dopamine receptor-mediated antiproliferation in a small cell lung cancer cell line, NCI-H69. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581818&form=6&db=m Heme induces neutrophil migration and reactive oxygen species generation through signaling pathways characteristic of chemotactic receptors. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17585904&form=6&db=m Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma beta-cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17593019&form=6&db=m Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17594911&form=6&db=m The role of beta-arrestins in the formyl peptide receptor-like 1 internalization and signaling. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17598476&form=6&db=m [G(i) proteins in regulation of water permeability of the rat kidney collecting tube epithelium cell membrane] causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17601518&form=6&db=m Pertussis toxin-induced cytokine differentiation and clonal expansion of T cells is mediated predominantly via costimulation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17603153&form=6&db=m 2-Arachidonoylglycerol enhances the phagocytosis of opsonized zymosan by HL-60 cells differentiated into macrophage-like cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17606321&form=6&db=m Antiproliferative effect of sphingosylphosphorylcholine in thyroid FRO cancer cells mediated by cell cycle arrest in the G2/M phase. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17609435&form=6&db=m Selective regulation of somatostatin receptor subtype signaling: evidence for constitutive receptor activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17609523&form=6&db=m Sphingosine-1-phosphate stimulates aldosterone secretion through a mechanism involving the PI3K/PKB and MEK/ERK 1/2 pathways. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17618307&form=6&db=m Nocistatin inhibits 5-hydroxytryptamine release in the mouse neocortex via presynaptic G(i/o) protein linked pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17620336&form=6&db=m The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17623667&form=6&db=m Translocation of activated heterotrimeric G protein Galpha(o) to ganglioside-enriched detergent-resistant membrane rafts in developing cerebellum. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17627999&form=6&db=m Nesfatin-1: distribution and interaction with a g protein-coupled receptor in the rat brain. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17629454&form=6&db=m Endothelial beta2 adrenergic signaling to AKT: role of Gi and SRC. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17630193&form=6&db=m Enzymatic digestion of the milk protein beta-casein releases potent chemotactic peptide(s) for monocytes and macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17635935&form=6&db=m Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17644088&form=6&db=m Role of cannabinoid CB1 receptors and Gi/o protein activation in the modulation of synaptosomal Na+,K+-ATPase activity by WIN55,212-2 and triangle up9-THC. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17645873&form=6&db=m Analysis of second messenger pathways stimulated by different chemokines acting at the chemokine receptor CCR5. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17646583&form=6&db=m Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17650109&form=6&db=m mGluR7 inhibits glutamate release through a PKC-independent decrease in the activity of P/Q-type Ca2+ channels and by diminishing cAMP in hippocampal nerve terminals. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17651798&form=6&db=m The neuropeptide pituitary adenylate cyclase activating polypeptide modulates Ca2+ and pro-inflammatory functions in human monocytes through the G protein-coupled receptors VPAC-1 and formyl peptide receptor-like 1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17651824&form=6&db=m Oligomerization of neuropeptide Y (NPY) Y2 receptors in CHO cells depends on functional pertussis toxin-sensitive G-proteins. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17652619&form=6&db=m Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17654493&form=6&db=m Prostaglandin E2 upregulates EGF-stimulated signaling in mitogenic pathways involving Akt and ERK in hepatocytes. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17682128&form=6&db=m The endogenous cannabinoid anandamide inhibits cromakalim-activated k+ currents in follicle-enclosed Xenopus oocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17682703&form=6&db=m [A field survey carried out on the confirmation of a pertussis case in a village of Kirikkale Province, Turkey] diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17684012&form=6&db=m Mitogen-activated protein kinase p38 regulates the Wnt/cyclic GMP/Ca2+ non-canonical pathway. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17689924&form=6&db=m Lysophosphatidic acid modulates c-Met redistribution and hepatocyte growth factor/c-Met signaling in human bronchial epithelial cells through PKC delta and E-cadherin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17692506&form=6&db=m Mastoparan inhibits beta-adrenoceptor-G(s) signaling by changing the localization of Galpha(s) in lipid rafts. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17692824&form=6&db=m A mastoparan analog without lytic effects and its stimulatory mechanisms in mast cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17698952&form=6&db=m Involvement of the 90-kDa Heat Shock Protein (Hsp-90) in CB2 Cannabinoid Receptor-Mediated Cell Migration: A New Role of Hsp-90 in Migration Signaling of a G Protein-Coupled Receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17699837&form=6&db=m Pulsed-field gel electrophoresis, pertactin, pertussis toxin S1 subunit polymorphisms, and surfaceome analysis of vaccine and clinical Bordetella pertussis strains. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17702953&form=6&db=m C-type natriuretic peptide enhances amylase release through NPR-C receptors in the exocrine pancreas. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17703360&form=6&db=m Activation of the human FPRL-1 receptor promotes Ca2+ mobilization in U87 astrocytoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17704825&form=6&db=m GPR55 and the vascular receptors for cannabinoids. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17704831&form=6&db=m Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17707868&form=6&db=m Cannabinoid receptor-mediated translocation of NO-sensitive guanylyl cyclase and production of cyclic GMP in neuronal cells. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17707940&form=6&db=m Involvement of Gq/11 in both integrin signal-dependent and -independent pathways regulating endothelin-induced neural progenitor proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17719584&form=6&db=m Lysophosphatidylethanolamine stimulates chemotactic migration and cellular invasion in SK-OV3 human ovarian cancer cells: involvement of pertussis toxin-sensitive G-protein coupled receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17719864&form=6&db=m DNA microarray analysis reveals a role for lysophosphatidic acid in the regulation of anti-inflammatory genes in MC3T3-E1 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17720743&form=6&db=m Heart/Cardiac Muscle: Cocaine- and amphetamine-regulated transcript (CART) peptide as an in vivo regulator of cardiac function in Rana ridibunda frog. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17721375&form=6&db=m Impact of a pertussis booster vaccination program in adolescents and adults on the epidemiology of pertussis in Austria. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17724201&form=6&db=m Characterization of IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in experimental autoimmune uveitis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17727628&form=6&db=m Formyl peptide-receptor like-1 requires lipid raft and extracellular signal-regulated protein kinase to activate inhibitor-kappaB kinase in human U87 astrocytoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17728215&form=6&db=m Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17766478&form=6&db=m Lysozyme, a mediator of sepsis, impairs the cardiac neural adrenergic response by nonendothelial release of NO and inhibitory G protein signaling. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17766482&form=6&db=m The effect of adrenomedullin on the L-type calcium current in myocytes from septic shock rats: signaling pathway. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17803052&form=6&db=m Inhibition of fatty acid transport and proliferative activity in tissue-isolated human squamous cell cancer xenografts perfused in situ with melatonin or eicosapentaenoic or conjugated linoleic acids. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17804686&form=6&db=m Plasmacytoid dendritic cells employ multiple cell adhesion molecules sequentially to interact with high endothelial venule cells molecular basis of their trafficking to lymph nodes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17854387&form=6&db=m Identification of NCAM-binding peptides promoting neurite outgrowth via a heterotrimeric G-protein-coupled pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17855138&form=6&db=m Purification and characterization of transducin from capybara Hydrochoerus hydrochaeris. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17881243&form=6&db=m The PLPp-specific T-cell population promoted by pertussis toxin is characterized by high frequencies of IL-17-producing cells. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17883436&form=6&db=m Alpha2-adrenoceptors couple to inhibition of R-type calcium currents in myenteric neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17884923&form=6&db=m Generation of a constitutive Na+-dependent inward-rectifier current in rat adult atrial myocytes by overexpression of Kir3.4. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17885920&form=6&db=m Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal bovine serum. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17886371&form=6&db=m [Modern strains of Bordetella pertussis: immunobiological properties and vaccine improvement] diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17888871&form=6&db=m Differential regulation of cyclic AMP synthesis by estrogen in MCF7 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17888875&form=6&db=m Lysophosphatidylglycerol stimulates chemotactic migration and tube formation in human umbilical vein endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17891920&form=6&db=m Monoclonal antibody that neutralizes pertussis toxin activities. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17892855&form=6&db=m Adenine-induced inhibition of Na(+)-ATPase activity: Evidence for involvement of the Gi protein-coupled receptor in the cAMP signaling pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17897634&form=6&db=m Chronic morphine treatment up-regulates mu opioid receptor binding in cells lacking filamin A. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17909096&form=6&db=m Stromal cell-derived factor-1/CXCL12 stimulates chemorepulsion of NOD/LtJ T-cell adhesion to islet microvascular endothelium. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17911632&form=6&db=m Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17915215&form=6&db=m Phosphorylation, desensitization and internalization of human alpha1B-adrenoceptors induced by insulin-like growth factor-I. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17918745&form=6&db=m Ebselen, a redox regulator containing a selenium atom, induces neurofilament M expression in cultured rat pheochromocytoma PC12 cells via activation of mitogen-activated protein kinase. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17921818&form=6&db=m Identification of the vasodilatory endothelial cannabinoid receptor in the human pulmonary artery. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17922024&form=6&db=m Agonist-dependent cannabinoid receptor signalling in human trabecular meshwork cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17924084&form=6&db=m Lysophosphatidic acid regulates blood glucose by stimulating myotube and adipocyte glucose uptake. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17928414&form=6&db=m Acute and delayed renal protection against renal ischemia and reperfusion injury with A1 adenosine receptors. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17929410&form=6&db=m [Evaluation of whole-cell and acellular pertussis vaccines effectiveness in clearance of experimental B. pertussis infection in mice] ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17932499&form=6&db=m Neutrophil apoptosis mediated by nicotinic acid receptors (GPR109A). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17934983&form=6&db=m Frequency of pertussis in children with prolongued cough. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17938165&form=6&db=m Pertussis Booster Vaccination in HIV-Infected Children Receiving Highly Active Antiretroviral Therapy. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17940199&form=6&db=m Inhibition of N-type calcium channels by activation of GPR35, an orphan receptor, heterologously expressed in rat sympathetic neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17951099&form=6&db=m Prothrombin fragments containing kringle domains induce migration and activation of human neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17951222&form=6&db=m Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17955442&form=6&db=m Delayed role of tumor necrosis factor- alpha in overcoming the effects of pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17958326&form=6&db=m Lysophosphatidylserine increases membrane potentials in rat C6 glioma cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17960042&form=6&db=m [Effects of G-Protein Regulators and Stylar S-RNase on the Growth and Ca(2+) Concentration of Pyrus pyrifolia Pollen Tube.] ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17964272&form=6&db=m Characterization of pertussis toxin by LC-MS/MS. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17967449&form=6&db=m Pertussis toxin induces parallel loss of neuropeptide Y Y1 receptor dimers and Gi alpha subunit function in CHO cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17968294&form=6&db=m Pertussis is under diagnosed in infants hospitalized with lower respiratory tract infection in the pediatric intensive care unit. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17973599&form=6&db=m Nifedipine-sensitive vascular reactivity of femoral arteries in WKY: the effects of pertussis toxin pretreatment and endothelium removal. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17975009&form=6&db=m Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17982695&form=6&db=m Galanin stimulates cortisol secretion from human adrenocortical cells through the activation of galanin receptor subtype 1 coupled to the adenylate cyclase-dependent signaling cascade. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17984291&form=6&db=m Serum amyloid A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl peptide receptor like-1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17986231&form=6&db=m Gi-coupled P2Y-ADP receptor mediates GSK-3 phosphorylation and beta-catenin nuclear translocation in granule neurons. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17989283&form=6&db=m Somatostatin peptides produce multiple effects on gating properties of native cone photoreceptor cGMP-gated channels that depend on circadian phase and previous illumination. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17992256&form=6&db=m Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17996730&form=6&db=m GPR35 is a functional receptor in rat dorsal root ganglion neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18027882&form=6&db=m Lysophosphatidic acid in malignant ascites stimulates migration of human mesenchymal stem cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18028998&form=6&db=m Leukotriene D(4) induces gene expression in human monocytes through cysteinyl leukotriene type I receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18032544&form=6&db=m CaR activation increases TNF production by mTAL cells via a Gi-dependent mechanism. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18038548&form=6&db=m [Pertussis toxin and cross-reactive antigens in dynamics of Bordetella pertussis cultivation] diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18039775&form=6&db=m Estrogens promote human testicular germ cell cancer through a membrane-mediated activation of extracellular regulated kinase and protein kinase A. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18042549&form=6&db=m Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18045877&form=6&db=m Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18045900&form=6&db=m Bradykinin-induced microglial migration mediated by B1-bradykinin receptors depends on Ca2+ influx via reverse-mode activity of the Na+/Ca2+ exchanger. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18046543&form=6&db=m Sphingosine-1-phosphate and endothelin-1 induce the expression of rgs16 protein in cardiac myocytes by transcriptional activation of the rgs16 gene. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18054784&form=6&db=m Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18065664&form=6&db=m Parenteral immunization of mice with a genetically inactivated pertussis toxin DNA vaccine induces cell-mediated immunity and protection. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18069042&form=6&db=m Two C-terminal peptides of human CKLF1 interact with the chemokine receptor CCR4. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18071676&form=6&db=m Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscle. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18073555&form=6&db=m Adenosine A1 but not A2a receptor agonist reduces hyperalgesia caused by a surgical incision in rats: a pertussis toxin-sensitive G protein-dependent process. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18079198&form=6&db=m Dehydroepiandrosterone stimulates endothelial proliferation and angiogenesis through extracellular signal-regulated kinase 1/2-mediated mechanisms. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18083345&form=6&db=m Endogenous RGS proteins attenuate Galpha(i)-mediated lysophosphatidic acid signaling pathways in ovarian cancer cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18087711&form=6&db=m Anti-inflammatory effect of angiotensin type 1 receptor antagonist on endotoxin-induced uveitis in rats. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18087810&form=6&db=m Effect of hydrogen peroxide on VIP-induced relaxation of the cat lower esophageal sphincter. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18093742&form=6&db=m Pertussis toxin B-oligomer suppresses human immunodeficiency virus-1 Tat-induced neuronal apoptosis through feedback inhibition of phospholipase C-beta by protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18096663&form=6&db=m Dopamine Inhibits Basal Prolactin Release in Pituitary Lactotrophs through Pertussis Toxin-Sensitive and -Insensitive Signaling Pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18096829&form=6&db=m Galectin-3 is an amplifier of inflammation in atherosclerotic plaque progression through macrophage activation and monocyte chemoattraction. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18097066&form=6&db=m Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18155002&form=6&db=m Sphingosine-1-phosphate-induced oxygen free radical generation in smooth muscle cell migration requires Galpha12/13 protein-mediated phospholipase C activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18157949&form=6&db=m A lysophosphatidic acid receptor lacking the PDZ-binding domain is constitutively active and stimulates cell proliferation. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18162186&form=6&db=m Activation of natriuretic peptide receptor-C attenuates the enhanced oxidative stress in vascular smooth muscle cells from spontaneously hypertensive rats: implication of Gialpha protein. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18162464&form=6&db=m Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18164221&form=6&db=m S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18171908&form=6&db=m Sphingosine 1-phosphate inhibits nitric oxide production induced by interleukin-1beta in rat vascular smooth muscle cells. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18171948&form=6&db=m p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18173920&form=6&db=m Tryptase enhances release of vascular endothelial growth factor from human osteoarthritic chondrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18174362&form=6&db=m CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18178251&form=6&db=m Adenosine, through the A(1) receptor, inhibits vesicular MHC class I cross-presentation by resting DC. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18178833&form=6&db=m Tax-inducible production of CC chemokine ligand 22 by human T cell leukemia virus type 1 (HTLV-1)-infected T cells promotes preferential transmission of HTLV-1 to CCR4-expressing CD4+ T cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18180373&form=6&db=m Inhibitory phosphorylation of soluble guanylyl cyclase by muscarinic m2 receptors via Gbetagamma-dependent activation of c-Src kinase. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18182056&form=6&db=m Co-expression of mu and delta opioid receptors as receptor-G protein fusions enhances both mu and delta signalling via distinct mechanisms. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18187234&form=6&db=m Amyloid-beta precursor protein mediates neuronal toxicity of amyloid beta through Go protein activation. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18187666&form=6&db=m In human macrophages the complement component C5a induces the expression of oncostatin M via AP-1 activation. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18190581&form=6&db=m Seroprevalence of IgG antibodies against Bordetella pertussis in healthy individuals aged 4-24 years in Turkey. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18191792&form=6&db=m Delivery of a Salmonella Typhi exotoxin from a host intracellular compartment. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18194436&form=6&db=m Endogenous cannabinoid anandamide inhibits nicotinic acetylcholine receptor function in mouse thalamic synaptosomes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18201245&form=6&db=m Retrograde transport of pertussis toxin in the mammalian cell. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202135&form=6&db=m Beta1-adrenoceptors in rat anterior pituitary may be constitutively active. Inverse agonism of CGP 20712A on basal 3',5'-cyclic adenosine 5'-monophosphate levels. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202153&form=6&db=m Gbetagamma dimers released in response to thyrotropin activate phosphoinositide 3-kinase and regulate gene expression in thyroid cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18204471&form=6&db=m Thrombin-promoted release of UDP-glucose from human astrocytoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18208547&form=6&db=m Type 1 angiotensin receptor (AT1-R)-mediated decrease in type 2 angiotensin receptor mRNA level is dependent on Gq and extracellular signal-regulated kinase 1//2 in AT1-R-transfected PC12 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18208582&form=6&db=m Beta3-adrenoceptors modulate left ventricular relaxation in the rat heart via the NO-cGMP-PKG pathway. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18209090&form=6&db=m Role of sphingosine 1-phosphate in the pathogenesis of Sjögren's syndrome. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18211822&form=6&db=m Activation of PKCbeta(II) and PKCtheta is essential for LDL-induced cell proliferation of human aortic smooth muscle cells via Gi-mediated Erk1/2 activation and Egr-1 upregulation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18216775&form=6&db=m Ultra-low-dose naloxone restores the antinociceptive effect of morphine and suppresses spinal neuroinflammation in PTX-treated rats. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18247041&form=6&db=m Rho GTPases mediated integrin alpha v beta 3 activation in sphingosine-1-phosphate stimulated chemotaxis of endothelial cells. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18248225&form=6&db=m Zebrafish Mir antagonizes Frizzled 7-induced gastrulation defects. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18248757&form=6&db=m Neonatal immunization with a single dose of recombinant BCG expressing subunit S1 from pertussis toxin induces complete protection against Bordetella pertussis intracerebral challenge. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18248957&form=6&db=m A novel collagen-binding peptide promotes osteogenic differentiation via Ca(2+)/calmodulin-dependent protein kinase II/ERK/AP-1 signaling pathway in human bone marrow-derived mesenchymal stem cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18249480&form=6&db=m Delta(9)-Tetrahydrocannabinol enhances MCF-7 cell proliferation via cannabinoid receptor-independent signaling. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18254249&form=6&db=m The signaling mechanism of the sphingosylphosphorylcholine-induced contraction in cat esophageal smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18256518&form=6&db=m Experimental autoimmune encephalomyelitis (EAE) induced by antigen pulsed dendritic cells in the C57BL/6 mouse: influence of injection route. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18263851&form=6&db=m The relationship between the metabolism of sphingomyelin species and the hemolysis of sheep erythrocytes induced by Clostridium perfringens {alpha}-toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18277540&form=6&db=m [Contents of antibodies to Bordetella pertussis antigens in patients with rheumatic diseases] diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18285510&form=6&db=m Endogenous regulators of G protein signaling differentially modulate full and partial mu-opioid agonists at adenylyl cyclase as predicted by a collision coupling model. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18288973&form=6&db=m Human immunodeficiency virus-induced apoptosis of human breast cancer cells via CXCR4 is mediated by the viral envelope protein but does not require CD4. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18294454&form=6&db=m The anti-infective peptide, innate defense-regulator peptide, stimulates neutrophil chemotaxis via a formyl peptide receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18296444&form=6&db=m Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18296501&form=6&db=m Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18309089&form=6&db=m Lysophosphatidic acid induces rapid and sustained decreases in epidermal growth factor receptor binding via different signaling pathways in BEAS-2B airway epithelial cells. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18309099&form=6&db=m Homocysteine inhibits arterial endothelial cell growth through transcriptional downregulation of fibroblast growth factor-2 involving G protein and DNA methylation. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18310443&form=6&db=m Mitogenic functions of endocrine gland-derived vascular endothelial growth factor and Bombina variegata 8 on steroidogenic adrenocortical cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18311185&form=6&db=m Signalling pathways for transactivation by dexmedetomidine of epidermal growth factor receptors in astrocytes and its paracrine effect on neurons. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18315950&form=6&db=m Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18321880&form=6&db=m Measuring immunoglobulin g antibodies to tetanus toxin, diphtheria toxin, and pertussis toxin with single-antigen enzyme-linked immunosorbent assays and a bead-based multiplex assay. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18326001&form=6&db=m Angiotensin II type 2 receptor stimulation increases the rate of NG108-15 cell migration via actin depolymerization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18326630&form=6&db=m Molecular mechanisms that control initiation and termination of physiological depolarization-evoked transmitter release. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18335579&form=6&db=m Inhibition of glucagon-signaling and downstream actions by interleukin 1beta and tumor necrosis factor alpha in cultured primary rat hepatocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18336961&form=6&db=m Kinetics of asthma- and allergy-associated immune response gene expression in peripheral blood mononuclear cells from vaccinated infants after in vitro re-stimulation with vaccine antigen. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18339308&form=6&db=m A new EAE model of brain demyelination induced by intracerebroventricular pertussis toxin. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18347022&form=6&db=m Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18365868&form=6&db=m Stimulation of extracellular signal-regulated kinases and proliferation in the human gastric cancer cells KATO-III by obestatin. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18367565&form=6&db=m Comparison of serological and real-time PCR assays to diagnose Bordetella pertussis infection in 2007. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18367611&form=6&db=m Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18368535&form=6&db=m The inflammatory effects of UDP-glucose in N9 microglia are not mediated by P2Y14 receptor activation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18368750&form=6&db=m [Domestic acellular pertussis vaccine] diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18371938&form=6&db=m Dopamine D4 receptors regulate intracellular calcium concentration in cultured chicken cone photoreceptor cells: relationship to dopamine receptor-mediated inhibition of cAMP formation. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18376419&form=6&db=m Modulation of sensory neuron potassium conductances by anandamide indicates roles for metabolites. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18384820&form=6&db=m Supersensitivity to mu-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Galpha protein subunits. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18397265&form=6&db=m Human B cells express the orphan chemokine receptor CRAM-A/B in a maturation-stage-dependent and CCL5-modulated manner. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18404453&form=6&db=m MPP(+)-induced cytotoxicity in neuroblastoma cells: Antagonism and reversal by guanosine. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18404463&form=6&db=m Different patterns of Ca(2+) signals are induced by low compared to high concentrations of P2Y agonists in microglia. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18404491&form=6&db=m Signaling pathways downstream of P2 receptors in human neutrophils. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18406577&form=6&db=m Differential involvement of Galpha16 in CC chemokine-induced stimulation of phospholipase Cbeta, ERK, and chemotaxis. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18407287&form=6&db=m Development and validation of a multiplex immunoassay for the simultaneous determination of serum antibodies to Bordetella pertussis, diphtheria and tetanus. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18407464&form=6&db=m Betagamma subunits of G(i/o) suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18408217&form=6&db=m Lysophosphatidic acid protects cancer cells from histone deacetylase (HDAC) inhibitor-induced apoptosis through activation of HDAC. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18409043&form=6&db=m Lysophosphatidylserine induces calcium signaling through Ki16425/VPC32183-sensitive GPCR in bone marrow-derived mast cells and in C6 glioma and colon cancer cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18410228&form=6&db=m Vitamin D receptor-dependent 1 alpha,25(OH)2 vitamin D3-induced anti-apoptotic PI3K/AKT signaling in osteoblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18412515&form=6&db=m The effects of pertussis toxin-treatment on integrated vasoactive response of vascular system in spontaneously hypertensive rats. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18416824&form=6&db=m Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18421238&form=6&db=m Microbial products trigger autoimmune ocular inflammation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18423379&form=6&db=m Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18424071&form=6&db=m G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFkappaB serine 536 phosphorylation in human keratinocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18424551&form=6&db=m N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18424662&form=6&db=m Mannosylated self-peptide inhibits the development of experimental autoimmune encephalomyelitis via expansion of nonencephalitogenic T cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18425627&form=6&db=m Effects of G protein and cGMP on phytochrome-mediated amaranthin synthesis inAmaranthus caudatus seedlings. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18432901&form=6&db=m Experimental autoimmune uveoretinitis in the rat and mouse. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18440175&form=6&db=m Development and evaluation of dual-target real-time polymerase chain reaction assays to detect Bordetella spp. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18443189&form=6&db=m Calpain-mediated regulation of the distinct signaling pathways and cell migration in human neutrophils. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18448594&form=6&db=m Acute inhibition of the betaine transporter by ATP and adenosine in renal MDCK cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18455250&form=6&db=m Atrial natriuretic factor intracellular signaling in the rat submandibular gland. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18455705&form=6&db=m Adenosine A1 receptor activation mediates NMDA receptor activity in a pertussis toxin-sensitive manner during normoxia but not anoxia in turtle cortical neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18458091&form=6&db=m beta-Adrenergic receptor activation induces internalization of cardiac Cav1.2 channel complexes through a beta-Arrestin 1-mediated pathway. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18461129&form=6&db=m Anti-inflammatory preconditioning by agonists of adenosine A1 receptor. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18467629&form=6&db=m Interaction of alpha1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18468510&form=6&db=m Lysophosphatidylglycerol stimulates chemotactic migration in human natural killer cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18472750&form=6&db=m Stimulation of Phospholipase A(2) by Toxic Main Group Heavy Metals: Partly Dependent on G-proteins? ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18472923&form=6&db=m Involvement of A pertussis Toxin Sensitive G-Protein in the Inhibition of Inwardly Rectifying K Currents by Platelet-Activating Factor in Guinea-Pig Atrial Cardiomyocytes. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18474367&form=6&db=m Glucagon increases contractility in ventricle but not in atrium of the rat heart. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18475453&form=6&db=m Mechanisms in bradykinin stimulated arachidonate release and synthesis of prostaglandin and platelet activating factor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18475595&form=6&db=m Cholinoceptor activation subserving the effects of interferon gamma on the contractility of rat ileum. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18480105&form=6&db=m Muscarinic receptors mediate stimulation of collagen synthesis in human lung fibroblasts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18480127&form=6&db=m G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18481020&form=6&db=m Dioleoyl phosphatidic acid induces morphological changes through an endogenous LPA receptor in C6 glioma cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18483566&form=6&db=m C-peptide and its C-terminal fragments improve erythrocyte deformability in type 1 diabetes patients. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18487315&form=6&db=m Voluntary exercise-induced changes in beta2-adrenoceptor signalling in rat ventricular myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18494935&form=6&db=m Mechanisms of the lysophosphatidic acid-induced increase in [Ca(2+)](i) in skeletal muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18495877&form=6&db=m Agouti-related peptide and MC3/4 receptor agonists both inhibit excitatory hypothalamic ventromedial nucleus neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18498620&form=6&db=m The role of Toll-like receptor-4 in pertussis vaccine-induced immunity. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18500752&form=6&db=m Pertussis toxin induces angiogenesis in brain microvascular endothelial cells. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18501427&form=6&db=m Requirement of Galphai in thymic homing and early T cell development. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18501717&form=6&db=m The anti-apoptotic activity associated with phosphatidylinositol transfer protein alpha activates the MAPK and Akt/PKB pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18508053&form=6&db=m Intracellular signal transduction by the extracellular calcium-sensing receptor of Xenopus melanotrope cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18508236&form=6&db=m Nerve growth factor-induced stimulation of p38 mitogen-activated protein kinase in PC12 cells is partially mediated via G(i/o) proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18509199&form=6&db=m The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18512331&form=6&db=m Bradycardia induced by Mesobuthus tamulus scorpion venom involves muscarinic receptor-G-protein-coupled cell signaling pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18513786&form=6&db=m S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment are mediated by Gi and Rac. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18515972&form=6&db=m Increased cAMP Signaling Can Ameliorate the Hypertensive Condition in Spontaneously Hypertensive Rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18524769&form=6&db=m M2 muscarinic receptors induce airway smooth muscle activation via a dual, Gbetagamma-mediated inhibition of large conductance Ca2+-activated K+ channel activity. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18525017&form=6&db=m Central G-alpha subunit protein-mediated control of cardiovascular function, urine output, and vasopressin secretion in conscious Sprague-Dawley rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18534242&form=6&db=m Poor immune responses to a birth dose of diphtheria, tetanus, and acellular pertussis vaccine. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18539914&form=6&db=m Mechanistic investigation of N,N-diethyl-4-(phenyl-piperidin-4-ylidenemethyl)-benzamide-induced insulin depletion in the rat and RINm5F cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18541717&form=6&db=m Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18551116&form=6&db=m The CB1 endocannabinoid system modulates adipocyte insulin sensitivity. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18559516&form=6&db=m The chemokine receptor CXCR6 and its ligand CXCL16 are expressed in carcinomas and inhibit proliferation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18562551&form=6&db=m Coupling specificity of NOP opioid receptors to pertussis-toxin-sensitive Galpha proteins in adult rat stellate ganglion neurons using small interference RNA. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18566004&form=6&db=m CC family chemokines directly regulate myoblast responses to skeletal muscle injury. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18566386&form=6&db=m Lipopolysaccharides from Bordetella pertussis and Bordetella parapertussis differently modulate human dendritic cell functions resulting in divergent prevalence of Th17-polarized responses. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18566521&form=6&db=m Activation of endothelial nitric oxide synthase by proanthocyanidin-rich fraction from Croton celtidifolius (Euphorbiaceae): involvement of extracellular calcium influx in rat thoracic aorta. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18570536&form=6&db=m Inactivation of G(i) proteins by pertussis toxin diminishes the effectiveness of adrenergic stimuli in conduit arteries from spontaneously hypertensive rats. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18571589&form=6&db=m The role of G proteins in thromospondin-1-induced vascular smooth muscle cell migration. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18573334&form=6&db=m CCR5 internalisation and signalling have different dependence on membrane lipid raft integrity. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18577183&form=6&db=m Ghrelin signalling in guinea-pig femoral artery smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18583341&form=6&db=m Activation of Galpha (i) and subsequent uncoupling of receptor-Galpha(i) signaling by Pasteurella multocida toxin. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18585471&form=6&db=m Lysophosphatidic acid-induced oxidized low-density lipoprotein uptake is class A scavenger receptor-dependent in macrophages. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18589786&form=6&db=m [Protection and its mechanism of catechin morphon on hypoxia-reoxynation induced injury in myocardial cells] therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18590534&form=6&db=m Comparative genomic profiling of Dutch clinical Bordetella pertussis isolates using DNA microarrays: identification of genes absent from epidemic strains. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18602434&form=6&db=m European Sero-Epidemiology Network 2: standardisation of immunoassay results for pertussis requires homogeneity in the antigenic preparations. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18606817&form=6&db=m High density lipoprotein-associated sphingosine 1-phosphate promotes endothelial barrier function. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18616930&form=6&db=m Lysophosphatidylserine stimulates chemotactic migration in U87 human glioma cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18622738&form=6&db=m Antilipolytic effect of calcium-sensing receptor in human adipocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18628659&form=6&db=m Characterization of umami receptor and coupling G protein in mouse taste cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18629502&form=6&db=m Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: synergism with 5-fluorouracil. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18632732&form=6&db=m LPA modulates monocyte migration directly and via LPA-stimulated endothelial cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18640169&form=6&db=m Outer membrane vesicles as acellular vaccine against pertussis. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18641693&form=6&db=m Interactions of multiple signaling pathways in neuropeptide Y-mediated bimodal vascular smooth muscle cell growth. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18657517&form=6&db=m Cryptide signaling: Amphiphilic peptide-induced exocytotic mechanisms in mast cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18657552&form=6&db=m Opioid receptor agonists enhance the phosphorylation state of Fas-associated death domain (FADD) protein in the rat brain: Functional interactions with casein kinase Ialpha, Galpha(i) proteins, and ERK1/2 signaling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18664376&form=6&db=m Melatonin receptor agonist ramelteon activates the extracellular signal-regulated kinase 1/2 in mouse cerebellar granule cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18670215&form=6&db=m Galphai protein-dependant extracellular signal-regulated kinase-1/2 activation is required for HIV-1 reverse transcription. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18680225&form=6&db=m Lysophosphatidic acid induced nuclear translocation of nuclear factor-kappaB in Panc-1 cells by mobilizing cytosolic free calcium. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18680554&form=6&db=m Lysophosphatidic acid-induced membrane ruffling and brain-derived neurotrophic factor gene expression are mediated by ATP release in primary microglia. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18680732&form=6&db=m Amitriptyline pretreatment preserves the antinociceptive effect of morphine in pertussis toxin-treated rats by lowering CSF excitatory amino acid concentrations and reversing the downregulation of glutamate transporters. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18684840&form=6&db=m The beta3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4-[2-[[3-[3-(acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human beta3-adrenoceptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18684973&form=6&db=m Annexin-1 mediates TNF-alpha-stimulated matrix metalloproteinase secretion from rheumatoid arthritis synovial fibroblasts. causal interaction,ongoing research,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18719394&form=6&db=m D2 dopamine receptors interact directly with N-type calcium channels and regulate channel surface expression levels. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18723610&form=6&db=m Stabilization of the pertussis toxin secretion apparatus by the C terminus of PtlD. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758243&form=6&db=m Transferability of dermal temperature histamine sensitisation test for estimation of pertussis toxin activity in vaccines. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758503&form=6&db=m Nonpeptidic antagonists of ETA and ETB receptors reverse the ET-1-induced sustained increase of cytosolic and nuclear calcium in human aortic vascular smooth muscle cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18760639&form=6&db=m Bacterial entry to the splenic white pulp initiates antigen presentation to CD8+ T cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18762220&form=6&db=m Genetic stability of the live attenuated Bordetella pertussis vaccine candidate BPZE1. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18765723&form=6&db=m Pertussis toxin inhibits early chemokine production to delay neutrophil recruitment in response to Bordetella pertussis respiratory tract infection in mice. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18769037&form=6&db=m Inhibition of the magnesium-sensitive TRPM7-like channel in cardiac myocytes by nonhydrolysable GTP analogs: involvement of phosphoinositide metabolism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18775853&form=6&db=m Effects of clenbuterol on contractility and Ca2+ homeostasis of isolated rat ventricular myocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18777088&form=6&db=m Homocysteine effects classical pathway of GPCR down regulation: Galpha(q/11), Galpha (12/13), G (i/o). therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18782261&form=6&db=m Effect of HLA genotype or CTLA-4 polymorphism on cytokine response in healthy children. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18784290&form=6&db=m Regulation of synaptic efficacy in hypocretin/orexin-containing neurons by melanin concentrating hormone in the lateral hypothalamus. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18787303&form=6&db=m Thrombin-stimulated proliferation of cultured human synovial fibroblasts through proteolytic activation of proteinase-activated receptor-1. ongoing research,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18793614&form=6&db=m cAMP imaging of cells treated with pertussis toxin, cholera toxin, and anthrax edema toxin. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18797942&form=6&db=m Antibody decay after immunisation of health-care workers with an acellular pertussis vaccine. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18801415&form=6&db=m Involvement of glutamate neurotransmission and N-methyl-d-aspartate receptor in the activation of midbrain dopamine neurons by 5-HT1A receptor agonists: an electrophysiological study in the rat. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18801904&form=6&db=m Progestin signaling through an olfactory G protein and membrane progestin receptor-alpha in Atlantic croaker sperm: potential role in induction of sperm hypermotility. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18802115&form=6&db=m Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18804464&form=6&db=m Collagen-binding motif peptide, a cleavage product of osteopontin, stimulates human neutrophil chemotaxis via pertussis toxin-sensitive G protein-mediated signaling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18810761&form=6&db=m Lanthanum enhances in vitro osteoblast differentiation via pertussis toxin-sensitive gi protein and ERK signaling pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18812167&form=6&db=m The macrophage-derived neutrophil chemotactic factor, MNCF: A lectin with TNF-alpha-like activities on neutrophils. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18813863&form=6&db=m Evaluation of novel cyclic analogues of apelin. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18814177&form=6&db=m CB1 cannabinoid receptor-dependent and -independent inhibition of depolarization-induced calcium influx in oligodendrocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18815223&form=6&db=m The monomeric G proteins AGS1 and Rhes selectively influence Galphai-dependent signaling to modulate N-type (CaV2.2) calcium channels. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18815228&form=6&db=m Essential role of EP3 subtype in prostaglandin E2-induced adhesion of mouse cultured and peritoneal mast cells to the Arg-Gly-Asp-enriched matrix. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18816412&form=6&db=m Bordetella pertussis isolates in Finland: serotype and fimbrial expression. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18816892&form=6&db=m Inhibition of adenylate cyclase activity in the goldfish melanophore is mediated by alpha2-adrenoceptors and a pertussis toxin-sensitive GTP-binding protein. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18822881&form=6&db=m [Pertussis seroprevalence and vaccination status in three selected province of Turkey] diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18830732&form=6&db=m LysoPtdOH Enhances CXCL16 Production Stimulated by LPS from Macrophages and Regulates T cell Migration. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18834877&form=6&db=m Monocyte migration: a novel effect and signaling pathways of catestatin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18837409&form=6&db=m [Effect of solution environment on the purification of pertussis toxin] diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18838247&form=6&db=m Analysis of retinal cellular infiltrate in experimental autoimmune uveoretinitis reveals multiple regulatory cell populations. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18838481&form=6&db=m Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18845176&form=6&db=m Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18845633&form=6&db=m N-type Ca(2+) -channels in murine pancreatic beta-cells are inhibited by an exclusive coupling with somatostatin receptor subtype 1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18852002&form=6&db=m Differences of humoral and cellular immune response to an acellular pertussis booster in adolescents with a whole cell or acellular primary vaccination. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18852255&form=6&db=m Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18854172&form=6&db=m The specific activation of TRPC4 by Gi protein subtype. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18923445&form=6&db=m Collagen Synthesis Is Suppressed in Dermal Fibroblasts by the Human Antimicrobial Peptide LL-37. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18931305&form=6&db=m Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18945902&form=6&db=m Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18952326&form=6&db=m Parenteral medium-chain triglyceride-induced neutrophil activation is not mediated by a Pertussis Toxin sensitive receptor. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18955903&form=6&db=m Functional coupling of mu-receptor-Galphai-tethered proteins in AtT20 cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18958425&form=6&db=m Regulation of lysophosphatidic acid-induced COX-2 expression by ERK1/2 activation in cultured feline esophageal epithelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18984584&form=6&db=m Reciprocal modulation of function between the D1 and D2 dopamine receptors and the Na+,K+-ATPase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18987746&form=6&db=m Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18992291&form=6&db=m Identification of novel synthetic peptide showing angiogenic activity in human endothelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18992715&form=6&db=m Concomitant activation of adenylyl cyclase suppresses the opposite influences of CB(1) cannabinoid receptor agonists on tyrosine hydroxylase expression. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18996352&form=6&db=m FPRL1-mediated induction of superoxide in LL-37-stimulated IMR90 human fibroblast. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19002711&form=6&db=m CFTR is activated through stimulation of purinergic P2Y(2) receptors. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19008645&form=6&db=m mu-Opioid receptor forms a functional heterodimer with cannabinoid CB1 receptor: electrophysiological and FRET assay analysis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19009346&form=6&db=m Multiple Gi proteins participate in nerve growth factor-induced activation of c-Jun N-terminal kinases in PC12 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19010327&form=6&db=m Liver myofibroblasts regulate infiltration and positioning of lymphocytes in human liver. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19014393&form=6&db=m The human antimicrobial peptide dermcidin activates normal human keratinocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19021033&form=6&db=m Prolactin induced production of cytokines in macrophages involves Ca++ and p42/44 MAP kinase signaling pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19026160&form=6&db=m Endothelium-derived hyperpolarizing factor mediated relaxations in pig coronary arteries do not involve Gi/o proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19027716&form=6&db=m Lipopolysaccharide induces autotaxin expression in human monocytic THP-1 cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19036707&form=6&db=m beta-Arrestin recruitment assay for the identification of agonists of the sphingosine 1-phosphate receptor EDG1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19037712&form=6&db=m The beta1-adrenergic receptor mediates extracellular signal-regulated kinase activation via Galphas. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19040745&form=6&db=m Immunomodulatory effects of recombinant BCG expressing pertussis toxin on TNF-alpha and IL-10 in a bladder cancer model. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19070673&form=6&db=m Regulation of mTOR and p70 S6 kinase by the muscarinic M4 receptor in PC12 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19071123&form=6&db=m Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctions. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19071179&form=6&db=m International Bordetella pertussis assay standardization and harmonization meeting report. Centers for Disease Control and Prevention, Atlanta, Georgia, United States, 19-20 July 2007. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19091788&form=6&db=m C-peptide reverses TGF-beta1-induced changes in renal proximal tubular cells: implications for treatment of diabetic nephropathy. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19098121&form=6&db=m Molecular mechanisms of corticotropin-releasing factor receptor-induced calcium signaling. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19098126&form=6&db=m In vitro hypoxia impairs beta2-adrenergic receptor signaling in primary rat alveolar epithelial cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19099223&form=6&db=m Inhibitory effect of hypochlorous acid on lower esophageal sphincter tone relaxation by vasoactive intestinal peptide. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19099561&form=6&db=m Role of cAMP in the promotion of colorectal cancer cell growth by prostaglandin E2. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19101595&form=6&db=m Short-chain fatty acid signaling pathways in bovine mammary epithelial cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19103765&form=6&db=m Role of neutrophils in response to Bordetella pertussis infection in mice. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19106171&form=6&db=m Cannabinoid agonists stimulate [3H]GABA release in the globus pallidus of the rat when G(i) protein-receptor coupling is restricted: role of dopamine D2 receptors. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19109185&form=6&db=m Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19109194&form=6&db=m Crosstalk between CXCR4/stromal derived factor-1 and VLA-4/VCAM-1 pathways regulates neutrophil retention in the bone marrow. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19109448&form=6&db=m Characterization of reference materials for human antiserum to pertussis antigens by an international collaborative study. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19129242&form=6&db=m LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19131507&form=6&db=m Constitutive somatostatin receptor activity determines tonic pituitary cell response. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19131510&form=6&db=m Involvement of G protein-coupled receptor 30 (GPR30) in rapid action of estrogen in primate LHRH neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19133990&form=6&db=m Targeting V1A-vasopressin receptors with [Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19141678&form=6&db=m Niacin stimulates adiponectin secretion through the GPR109A receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19151257&form=6&db=m Endothelin downregulates SERCA2 gene and protein expression in adult rat ventricular myocytes: regulation by pertussis toxin-sensitive Gi protein and cAMP. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19158267&form=6&db=m Changes in genetic diversity of the Bordetella pertussis population in the United Kingdom between 1920 and 2006 reflect vaccination coverage and emergence of a single dominant clonal type. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19159405&form=6&db=m Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19161388&form=6&db=m Multiple roles of Gi/o protein-coupled receptors in control of action potential secretion coupling in pituitary lactotrophs. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19165133&form=6&db=m Pertussis vaccine: a critique. causal interaction,diagnostic usage,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19166874&form=6&db=m An fMLP receptor is involved in activation of phagocytosis by hemocytes from specific insect species. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19168957&form=6&db=m Mucosal vaccination approach against mosquito-borne Japanese encephalitis virus. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19186097&form=6&db=m Virulence factor secretion and translocation by Bordetella species. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19186178&form=6&db=m Activation of PI3K/Akt signaling has a dominant negative effect on IL-12 production by macrophages infected with Leishmania amazonensis promastigotes. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19186540&form=6&db=m [Diagnostic value of IgG, IgA, and IgM to Bordetella pertussis antigens in patients with pertussis] diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19188909&form=6&db=m Anaphylaxis to a self-peptide in the absence of mast cells or histamine. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19191907&form=6&db=m Calpain inhibition induces activation of the distinct signalling pathways and cell migration in human monocytes. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19195857&form=6&db=m Pinoresinol-4,4'-di-O-beta-D-glucoside from Valeriana officinalis root stimulates calcium mobilization and chemotactic migration of mouse embryo fibroblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19204147&form=6&db=m The role of the GPR91 ligand succinate in hematopoiesis. causal interaction,ongoing research,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19205621&form=6&db=m Activation of CD47 receptors causes histamine secretion from mast cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19207808&form=6&db=m Rapid action of oestrogen in luteinising hormone-releasing hormone neurones: the role of GPR30. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19210476&form=6&db=m Regulation of Basal and stimulated prolactin release in prolactin-secreting rat pituitary tumors*. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19215387&form=6&db=m Expression of Histamine HReceptors in Xenopus Oocytes Injected with Messenger Ribonucleic Acid from Bovine Adrenal Medulla: Pertussis Toxin Insensitive Activation of Membrane Chloride Currents. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19215417&form=6&db=m Both pertussis toxin-sensitive and insensitive g-proteins link melatonin receptor to inhibition of adenylate cyclase in the ovine pars tuberalis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19215442&form=6&db=m Differential mechanisms of dopamine and somatostatin inhibition of prolactin secretion from anterior pituitary cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19215501&form=6&db=m Phospholipase A and Somatostatin Release are Activated in Response to N-Methyl-D-Aspartate Receptor Stimulation in Hypothalamic Neurons in Primary Culture. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19220977&form=6&db=m Evaluation of two serological methods for potency testing of whole cell pertussis vaccines. diagnostic usage,ongoing research,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19225179&form=6&db=m Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19228106&form=6&db=m SPHINGOSINE 1-PHOSPHATE REGULATION OF EXTRACELLULAR SIGNAL REGULATED KINASE-1/2 IN EMBYRONIC STEM CELLS. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19237584&form=6&db=m Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19239906&form=6&db=m Phosphodiesterases inhibition unmask a positive inotropic effect mediated by beta2-adrenoceptors in rat ventricular myocardium. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19249174&form=6&db=m Problem solved: a modified enzyme-linked immunosorbent assay for detection of human antibodies to pertussis toxin eliminates false-positive results occurring at analysis of heat-treated sera. diagnostic usage,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19250659&form=6&db=m Coagulation Factor Xa inhibits cancer cell migration via Protease-activated receptor-1 activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19262138&form=6&db=m P-selectin cross-links PSGL-1 and enhances neutrophil adhesion to fibrinogen and ICAM-1 in a Src kinase-dependent, but GPCR-independent mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19264905&form=6&db=m Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19265162&form=6&db=m C3a and C5a are chemotactic factors for human mesenchymal stem cells, which cause prolonged ERK1/2 phosphorylation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19275929&form=6&db=m Activation of G(i) induces mechanical hyperalgesia poststress or inflammation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19278729&form=6&db=m Synergistic BM-DC activation and immune induction by the oral vaccine vector Streptococcus gordonii and exogenous tumor necrosis factor. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19285060&form=6&db=m Time-dependent vascular actions of cannabidiol in the rat aorta. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19285497&form=6&db=m Sphingosine-1-phosphate increases human alveolar epithelial IL-8 secretion, proliferation and neutrophil chemotaxis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19295255&form=6&db=m Segment-dependent activation of muscarinic acetylcholine receptor-mediated [35S]Guanosine-5'-O-(gamma-thiotriphosphate) binding in airway tissue membranes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19309359&form=6&db=m Inhibition of transmitter release from rat sympathetic neurons via presynaptic M(1) muscarinic acetylcholine receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19309361&form=6&db=m Different response patterns of several ligands at the sphingosine-1-phosphate receptor subtype 3 (S1P(3)). therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19319020&form=6&db=m Maternally derived antibodies against Bordetella pertussis antigens pertussis toxin and filamentous hemagglutinin in preterm and full term newborns. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19320820&form=6&db=m Mutagenesis studies toward understanding the intracellular signaling mechanism of antithrombin. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19330217&form=6&db=m Mechanical hypernociception in experimental autoimmune encephalomyelitis. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19336886&form=6&db=m CXCL12-mediated induction of plasminogen activator inhibitor-1 expression in human CXCR4 positive astroglioma cells. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19339617&form=6&db=m 17beta-estradiol-mediated neuroprotection and ERK activation require a pertussis toxin-sensitive mechanism involving GRK2 and beta-arrestin-1. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19339661&form=6&db=m Gi-dependent cell signaling responses of the human P2Y14-receptor in model cell systems. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19339694&form=6&db=m Activin A induces dendritic cell migration through the polarized release of CXCL12 and CXCL14. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19342687&form=6&db=m Mitocryptide-2: purification, identification, and characterization of a novel cryptide that activates neutrophils. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19344370&form=6&db=m G Protein independent phosphorylation and internalization of the delta-opioid receptor. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19345424&form=6&db=m alpha4 Integrin/FN-CS1 mediated leukocyte adhesion to brain microvascular endothelial cells under flow conditions. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19346259&form=6&db=m Murine bone marrow-derived mast cells express chemoattractant receptor-homologous molecule expressed on T-helper class 2 cells (CRTh2). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19349368&form=6&db=m Arsenic requires sphingosine-1-phosphate type 1 receptors to induce angiogenic genes and endothelial cell remodeling. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19362548&form=6&db=m delta-Opioid receptor-stimulated Akt signaling in neuroblastomaxglioma (NG108-15) hybrid cells involves receptor tyrosine kinase-mediated PI3K activation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19362805&form=6&db=m Steroid treatments in mice do not alter the number and function of regulatory T cells, but amplify cyclophosphamide-induced autoimmune disease. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19363218&form=6&db=m Pertussis toxin-sensitive G-proteins regulate lymphoid lineage specification in multipotent hematopoietic progenitors. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19368557&form=6&db=m Interactions between the amyloid precursor protein C-terminal domain and G proteins mediate calcium dysregulation and amyloid beta toxicity in Alzheimer's disease. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19374869&form=6&db=m Sphingosine-1-phosphate regulates RGS2 and RGS16 mRNA expression in vascular smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19377620&form=6&db=m [Chemoattractive effects of chemokine-like factor 1 on human arterial smooth muscle cells.] diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19380418&form=6&db=m Parstatin: a cryptic peptide involved in cardioprotection after ischemia and reperfusion injury. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19380820&form=6&db=m Pertussis toxin signals through the TCR to initiate cross-desensitization of the chemokine receptor CXCR4. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19392771&form=6&db=m Elevated Ca(2+) influx-inducing activity toward mast cells in pretransfusion sera from patients who developed transfusion-related adverse reactions. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19397943&form=6&db=m Molecular cloning and expression of two melanin-concentrating hormone receptors in goldfish. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19400930&form=6&db=m Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A2. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19403525&form=6&db=m Thromboxane A2 receptor activates a rock/LKB1/Pten pathway to attenuate endothelium insulin signaling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19409222&form=6&db=m Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats and prevents glutamate transporter downregulation by suppressing the p38 mitogen-activated protein kinase signaling pathway. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19409890&form=6&db=m Emodin augments calcium activated chloride channel in colonic smooth muscle cells by Gi/Go protein. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19416170&form=6&db=m Relaxin family peptide receptor 1 activation stimulates peroxisome proliferator-activated receptor gamma. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19422377&form=6&db=m Characterization of P2Y receptor subtypes functionally expressed on neonatal rat cardiac myofibroblasts. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19422392&form=6&db=m Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19423765&form=6&db=m PROGESTERONE RECEPTOR A (PRA) and PRB -INDEPENDENT EFFECTS OF PROGESTERONE ON GNRH RELEASE. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19426546&form=6&db=m Seroprevalence of Immunoglobulin G antibodies against pertussis toxin among asymptomatic medical students in the west of Iran: a cross sectional study. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19428552&form=6&db=m Immunoglobulin A with protease activity secreted in human milk activates PAR-2 receptors, of intestinal epithelial cells HT-29, and promotes beta-defensin-2 expression. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19429774&form=6&db=m Hypoxia-induced Mitogenic Factor/FIZZ1 Induces Intracellular Calcium Release Through the PLC-IP3 Pathway. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19433984&form=6&db=m Cardiomyocyte S1P1 Receptor-mediated Extracellular Signal-related Kinase Signaling and Desensitization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19439178&form=6&db=m Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC eposilon pathway. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19445974&form=6&db=m Cannabinoid CB1 receptor elevation of intracellular calcium in neuroblastoma SH-SY5Y cells: interactions with muscarinic and delta-opioid receptors. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19447154&form=6&db=m The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19448142&form=6&db=m CB1 receptor-independent actions of SR141716 on G-protein signaling: coapplication with the mu-opioid agonist Tyr-D-Ala-Gly-(NMe)Phe-Gly-ol unmasks novel, pertussis toxin-insensitive opioid signaling in mu-opioid receptor-Chinese hamster ovary cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19450576&form=6&db=m The roles of alpha2-adrenoceptor subtypes in the control of cervical resistance in the late-pregnant rat. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19452232&form=6&db=m Involvement of signaling pathways in bovine sperm motility, and effect of ergot alkaloids. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19457067&form=6&db=m P2X7 and P2Y13 purinergic receptors mediate intracellular calcium responses to BzATP in rat cerebellar astrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19457093&form=6&db=m Inhibition of EGF-induced ERK/MAP kinase-mediated astrocyte proliferation by mu opioids: integration of G protein and beta-arrestin 2-dependent pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19463918&form=6&db=m N-Methyl-d-aspartate receptor antagonist d-AP5 prevents pertussis toxin-induced alterations in rat spinal cords by inhibiting increase in concentrations of spinal CSF excitatory amino acids and downregulation of glutamate transporters. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19464556&form=6&db=m Generation of plant-derived recombinant DTP subunit vaccine. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19473985&form=6&db=m Kynurenic acid triggers firm arrest of leukocytes to vascular endothelium under flow conditions. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19478075&form=6&db=m GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19480581&form=6&db=m Seroprevalence and placental transportation of maternal antibodies specific for Neisseria meningitidis serogroup C, Haemophilus influenzae type B, diphtheria, tetanus, and pertussis. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19486272&form=6&db=m Antineoplastic effects of melatonin on a rare malignancy of mesenchymal origin: melatonin receptor-mediated inhibition of signal transduction, linoleic acid metabolism and growth in tissue-isolated human leiomyosarcoma xenografts. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19494301&form=6&db=m A single nucleotide polymorphism in Tyk2 controls susceptibility to experimental allergic encephalomyelitis. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19494508&form=6&db=m PI3Kgamma differentially regulates FcepsilonRI-mediated degranulation and migration of mast cells by and toward antigen. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19505377&form=6&db=m Amyloid beta peptides trigger CD47-dependent mast cell secretory and phagocytic responses. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19506935&form=6&db=m Effects of cannabinoids on caffeine contractures in slow and fast skeletal muscle fibers of the frog. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19522735&form=6&db=m The D(3) dopamine receptor inhibits dopamine release in PC-12/hD3 cells by autoreceptor signaling via PP-2B, CK1, and Cdk-5. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19523456&form=6&db=m Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19528165&form=6&db=m Role of PCR in the diagnosis of pertussis infection in infants: 5 years' experience of provision of a same-day real-time PCR service in England and Wales from 2002 to 2007. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19536741&form=6&db=m Incidence of seropositivity to bordetella pertussis and mycoplasma pneumoniae infection in patients with chronic laryngotracheitis. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19542482&form=6&db=m Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh). ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19551286&form=6&db=m Acellular and "low" pertussis vaccines: adverse events and the role of mutations. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19561030&form=6&db=m Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a Pertussis toxin sensitive pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19563736&form=6&db=m Signaling pathways involved in DNA synthesis and migration in response to lysophosphatidic acid and low-density lipoprotein in coronary artery smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19573542&form=6&db=m Corticotropin releasing factor-induced ERK phosphorylation in AtT20 cells occurs via a cAMP-dependent mechanism requiring EPAC2. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19574994&form=6&db=m Adenosine A(1) receptor-mediated transactivation of the EGF receptor produces a neuroprotective effect on cortical neurons in vitro. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19574999&form=6&db=m Regulation of gap-junction protein connexin 43 by beta-adrenergic receptor stimulation in rat cardiomyocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19577594&form=6&db=m Analysis of Swedish Bordetella pertussis isolates with three typing methods: characterization of an epidemic lineage. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19584307&form=6&db=m Rescue of functional F508del cystic fibrosis transmembrane conductance regulator by vasoactive intestinal peptide in the human nasal epithelial cell line JME/CF15. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19596995&form=6&db=m Genetically detoxified pertussis toxin induces Th1/Th17 immune response through MAPKs and IL-10-dependent mechanisms. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19603543&form=6&db=m Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19625643&form=6&db=m CCR7 ligands are required for development of experimental autoimmune encephalomyelitis through generating IL-23-dependent Th17 cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19628000&form=6&db=m Salvinorin A exerts opposite presynaptic controls on neurotransmitter exocytosis from mouse brain nerve terminals. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19632319&form=6&db=m FcepsilonRI-mediated mast cell migration: signaling pathways and dependence on cytosolic free Ca2+ concentration. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19636412&form=6&db=m CD47 regulates collagen I-induced cyclooxygenase-2 expression and intestinal epithelial cell migration. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19640558&form=6&db=m Kaposi sarcoma-associated herpes virus (KSHV) G protein-coupled receptor (vGPCR) activates the ORF50 lytic switch promoter: a potential positive feedback loop for sustained ORF50 gene expression. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19640932&form=6&db=m The chromogranin A-derived peptides vasostatin-I and catestatin as regulatory peptides for cardiovascular functions. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19642196&form=6&db=m Down-modulation of programmed death 1 alters regulatory T cells and promotes experimental autoimmune encephalomyelitis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19646975&form=6&db=m Evidence of TRPV1 receptor and PKC signaling pathway in the antinociceptive effect of amyrin octanoate. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19651868&form=6&db=m Characterization of a unique ADP-ribosyltransferase of Mycoplasma penetrans. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19654912&form=6&db=m Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19657033&form=6&db=m GABAergic transmission to gonadotropin-releasing hormone (GnRH) neurons is regulated by GnRH in a concentration-dependent manner engaging multiple signaling pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19661323&form=6&db=m Possible mechanism of CCL2-induced Akt activation in prostate cancer cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19666155&form=6&db=m First report and detailed characterization of B. pertussis isolates not expressing Pertussis Toxin or Pertactin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19669929&form=6&db=m Leukotactin-1/CCL15 induces cell migration and differentiation of human eosinophilic leukemia EoL-1 cells through PKCdelta activation. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19679818&form=6&db=m P2Y5 is a G{alpha}i, G{alpha}12/13 G Protein Coupled Receptor Activated by Lysophosphatidic Acid that Reduces Intestinal Cell Adhesion. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19680683&form=6&db=m Lysophosphatidylcholine- and MCP-1-induced chemotaxis of monocytes requires potassium channel activity. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19682558&form=6&db=m Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats by reversing the coupling of mu-opioid receptors from Gs-protein to coupling to Gi-protein. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19696103&form=6&db=m Overcoming Codon-Usage Bias in Heterologous Protein Expression in Streptococcus gordonii. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19696112&form=6&db=m Salmonella enterica serotype Typhimurium DT104 ArtA-dependent modification of pertussis toxin-sensitive G proteins in the presence of [32P]NAD. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19703720&form=6&db=m Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19703961&form=6&db=m Laminin enhances beta(2)-adrenergic receptor stimulation of L-type Ca(2+) current via cytosolic phospholipase A(2) signalling in cat atrial myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19706594&form=6&db=m Agonist dose-dependent PKA and GRK phosphorylation regulate {beta}2 adrenoceptor coupling to Gi proteins in cardiomyocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19709567&form=6&db=m Inhibition of renal Na+-ATPase activity by inosine is mediated by A1 receptor-induced inhibition of the cAMP signaling pathway. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19716891&form=6&db=m Activation of choline kinase by extracellular Ca2+ is Ca(2+)-sensing receptor, Galpha12 and Rho-dependent in breast cancer cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19719902&form=6&db=m The utility of seroepidemiology for tracking trends in pertussis infection. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19724056&form=6&db=m On the adaptation of endosteal stem cell niche function in response to stress. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19725100&form=6&db=m Fulminant pertussis: a multi-center study with new insights into the clinico-pathological mechanisms. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19725791&form=6&db=m Seroprevalence of Bordetella pertussis infection during pregnancy measured by IgG antibodies against pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19729085&form=6&db=m IgG responses after booster vaccination with different pertussis vaccines in Dutch children 4 years of age: Effect of vaccine antigen content. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19742132&form=6&db=m Receptor-Mediated Vascular Smooth Muscle Migration Induced by LPA Involves p38 Mitogen-Activated Protein Kinase Pathway Activation. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19748526&form=6&db=m The role of G-proteins in the dimerisation of human somatostatin receptor types 2 and 5. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19751581&form=6&db=m Bordetella pertussis strains with increased toxin production associated with pertussis resurgence. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19752150&form=6&db=m Melanin-concentrating hormone reduces somatolactin release from cultured goldfish pituitary cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19756945&form=6&db=m The central analgesia induced by antimigraine drugs is independent from Gi proteins: superiority of a fixed combination of indomethacin, prochlorperazine and caffeine, compared to sumatriptan, in an in vivo model. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19757175&form=6&db=m The role of lysophosphatidic acid receptors in phenotypic modulation of vascular smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19759900&form=6&db=m Pertussis toxin stimulates IL-17 production in response to Bordetella pertussis infection in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19766167&form=6&db=m Antibody binding to cell surface amyloid precursor protein induces neuronal injury by deregulating the phosphorylation of focal adhesion signaling related proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19769944&form=6&db=m Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca2+ pathway in a lipid raft-dependent manner. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19777447&form=6&db=m Lanthanum suppresses osteoblastic differentiation via pertussis toxin-sensitive G protein signaling in rat vascular smooth muscle cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19778812&form=6&db=m [Role of sphingosine 1-phosphate receptor signaling in hematopoietic stem/progenitor cell transmigration.] ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19781563&form=6&db=m Ginsenoside Rb1 protects against 6-hydroxydopamine-induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/Akt/Nrf2-dependent pathway in human dopaminergic cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19781706&form=6&db=m Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19782111&form=6&db=m Construction of an unmarked recombinant BCG expressing a pertussis antigen by auxotrophic complementation: Protection against Bordetella pertussis challenge in neonates. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19804820&form=6&db=m Endothelin-1 induces p66Shc activation through EGF receptor transactivation: Role of beta(1)Pix/Galpha(i3) interaction. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19805481&form=6&db=m Enhancement of Th1 Lung Immunity Induced by Recombinant Mycobacterium bovis BCG Attenuates Airway Allergic Disease. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19808657&form=6&db=m Insulin-like Growth Factor Binding Protein-5 Stimulates Growth of Human Intestinal Muscle Cells by Activation of G{alpha}i3. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19810093&form=6&db=m Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with patient survival. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19812588&form=6&db=m Pertussis antibodies in postpartum women and their newborns. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19843937&form=6&db=m Functional expression of formyl peptide receptor family in human NK cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19851834&form=6&db=m Histamine stimulates human lung fibroblast migration. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19861419&form=6&db=m GRIN1 regulates mu-opioid receptor activities by tethering the receptor and G protein in the lipid raft. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19861585&form=6&db=m Apelin is necessary for the maintenance of insulin sensitivity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19864325&form=6&db=m EPIDERMAL GROWTH FACTOR INCREASES LYSOPHOSPHATIDIC ACID PRODUCTION IN HUMAN OVARIAN CANCER CELLS: ROLES FOR PHOSPHOLIPASE D2 AND RECEPTOR TRANSACTIVATION. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19879871&form=6&db=m C-terminal deletion of metabotropic glutamate receptor 1 selectively abolishes coupling to Galphaq. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19879977&form=6&db=m Bordetella pertussis and vaccination: the persistence of a genetically monomorphic pathogen. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19885020&form=6&db=m P2 Receptor-mediated Inhibition of Vasopressin-stimulated Fluid Transport and cAMP Responses in AQP2-transfected MDCK Cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19887885&form=6&db=m Regulators involved in the electrically stimulated response of feline esophageal smooth muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19896471&form=6&db=m UDP-glucose acting at P2Y14 receptors is a mediator of mast cell degranulation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19899804&form=6&db=m Characterization of a key neutralizing epitope on pertussis toxin recognized by monoclonal antibody 1B7. causal interaction,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19903011&form=6&db=m Glucagon receptor mediates calcium signaling by coupling to G alpha q/11 and G alpha i/o in HEK293 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19904746&form=6&db=m Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19906118&form=6&db=m Genetic disruption of G proteins, G(i2)alpha or G(o)alpha, does not abolish inotropic and chronotropic effects of stimulating muscarinic cholinoceptors in atrium. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19910453&form=6&db=m Agonist-biased signaling at the sst2A receptor: the multi-somatostatin analogs KE108 and SOM230 activate and antagonize distinct signaling pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19912760&form=6&db=m Guanine nucleotides and pertussis toxin alter agonist binding to rat septal V(1)-vasopressin receptors. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19912780&form=6&db=m Bradykinin modulates the electrophysiology of cultured rat sensory neurons through a pertussis toxin-insensitive G protein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19912822&form=6&db=m Differential sensitivity of phosphoinositide metabolism to sodium fluoride and carbachol treatments in PC12 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19912854&form=6&db=m PKC modulation of inhibitory coupling of angiotensin II receptors with adenylate cyclase in lactotroph cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19912929&form=6&db=m Ligand Binding and Functional Properties of the Rat Somatostatin Receptor SSTR4 Stably Expressed in Chinese Hamster Ovary Cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19912931&form=6&db=m Characterization and functional expression of a somatostatin receptor coupled to adenylyl cyclase. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19913582&form=6&db=m Alteration of lymphocyte opioid receptors in methadone maintenance subjects. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19915703&form=6&db=m The influences of g proteins, ca, and k channels on electrical field stimulation in cat esophageal smooth muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19925780&form=6&db=m Prostaglandin D2 induces the production of human beta-defensin-3 in human keratinocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19936228&form=6&db=m G(i)-coupled GPCR signaling controls the formation and organization of human pluripotent colonies. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19938193&form=6&db=m Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E(2) and cytokines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19940980&form=6&db=m Involvement of Gi/o proteins and GIRK channels in the potentiation of morphine-induced spinal analgesia in acutely inflamed mice. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19941995&form=6&db=m The cAMP assay: a functional in vitro alternative to the in vivo Histamine Sensitization test. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19943954&form=6&db=m Go contributes to olfactory reception in Drosophila melanogaster. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19945417&form=6&db=m Bordetella pertussis vaccine strains and circulating isolates in Serbia. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19950836&form=6&db=m Comparison of nasopharyngeal culture, polymerase chain reaction (PCR) and serological test for diagnosis of pertussis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19961262&form=6&db=m Influence of pertussis toxin pretreatment on the development of L-NAME-induced hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19970690&form=6&db=m In Vivo Neutralization of Pertussis Toxin with Pertussis Antitoxin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20004081&form=6&db=m Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20015194&form=6&db=m A novel pathway for receptor-mediated post-translational activation of inducible nitric oxide synthase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20019358&form=6&db=m Evaluation of experimental autoimmune uveitis in mice treated with FTY720. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20021566&form=6&db=m D3 dopamine receptor signals to activation of phospholipase D through a complex with Rho. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20023216&form=6&db=m CCR6 ligands inhibit HIV by inducing APOBEC3G. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20025817&form=6&db=m The role of glial cells in influencing neurite extension by dorsal root ganglion cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20026661&form=6&db=m Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20036273&form=6&db=m Induction of microvascular leakage and histamine release by promutoxin, an Arg49 phospholipase A2. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20038462&form=6&db=m G-protein-coupled receptor independent, immunomodulatory properties of chemokine CXCL9. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20042073&form=6&db=m The chemokine CXCL13 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute Lyme neuroborreliosis. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20050185&form=6&db=m Multiple muscarinic pathways mediate the suppression of voltage-gated Ca2+ channels in mouse intestinal smooth muscle cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20050977&form=6&db=m The endogenous cannabinoid, anandamide, inhibits dopamine transporter function by a receptor-independent mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20061542&form=6&db=m High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20074556&form=6&db=m Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20078557&form=6&db=m Seroprevalence of pertussis antitoxin (anti-PT) in Sweden before and 10 years after the introduction of a universal childhood pertussis vaccination program. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20080636&form=6&db=m Resolvin D1 binds human phagocytes with evidence for proresolving receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20095429&form=6&db=m [Antigenic composition and serologic characteristics of domestic acellular pertussis vaccine] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20095432&form=6&db=m [Engineering of attenuated Bordetella pertussis bacteria producing immunogenic non-toxic form of pertussis toxin] ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20097289&form=6&db=m Two-pore potassium ion channels are inhibited by both G(q/11)- and G(i)-coupled P2Y receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20110378&form=6&db=m Gbetagamma signaling promotes breast cancer cell migration and invasion. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20120949&form=6&db=m [The frequency of detection of IgA, IgG and IgM antibodies to pertussis toxin in patients with respiratory tract infections in Poland] causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20123053&form=6&db=m Modified binding assay for improved sensitivity and specificity in the detection of residual pertussis toxin in vaccine preparations. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20130184&form=6&db=m In the developing rat hippocampus, endogenous activation of presynaptic kainate receptors reduces GABA release from mossy fiber terminals. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20130777&form=6&db=m Determinants Present in the Receptor Carboxy Tail Are Responsible for Differences in Subtype-Specific Coupling of beta-Adrenergic Receptors to Phosphoinositide 3-Kinase. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20136843&form=6&db=m N-arachidonoyl glycine, an endogenous lipid that acts as a vasorelaxant via nitric oxide and large conductance calcium-activated potassium channels. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20144450&form=6&db=m Collaborative study on a Guinea pig serological method for the assay of acellular pertussis vaccines. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20149859&form=6&db=m Membrane-impermeable estrogen is involved in regulation of calbindin-D9k expression via non-genomic pathways in a rat pituitary cell line, GH3 cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20159949&form=6&db=m Modulation of silent and constitutively active nociceptin/orphanin FQ receptors by potent receptor antagonists and Na+ ions in rat sympathetic neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20160007&form=6&db=m The nonpsychoactive cannabinoid cannabidiol inhibits 5-hydroxytryptamine3A receptor-mediated currents in Xenopus laevis oocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20177146&form=6&db=m A pertussis toxin sensitive G-protein-independent pathway is involved in serum amyloid A-induced formyl peptide receptor 2-mediated CCL2 production. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20180883&form=6&db=m Nuclear factor-kappaB activation regulates cyclooxygenase-2 induction in human astrocytes in response to CXCL12: role in neuronal toxicity. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20186548&form=6&db=m HL-1 cells express an inwardly rectifying K(+) current activated via muscarinic receptors comparable to that in mouse atrial myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20189994&form=6&db=m Morphine-like opiates selectively antagonize receptor-arrestin interactions. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20190140&form=6&db=m Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20193059&form=6&db=m Maternal allergen immunisation to prevent sensitisation in offspring: Th2-polarising adjuvants are more efficient than a Th1-polarising adjuvant in mice. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20197280&form=6&db=m Agonist-selective dynamic compartmentalization of human Mu opioid receptor as revealed by resolutive FRAP analysis. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20206117&form=6&db=m Characterization of pertussis toxoid by two-dimensional liquid chromatography-tandem mass spectrometry. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20206685&form=6&db=m The M3-muscarinic acetylcholine receptor stimulates glucose uptake in L6 skeletal muscle cells by a CaMKK-AMPK-dependent mechanism. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20209633&form=6&db=m Regulation of spontaneous Ca(2+) spikes by metabotropic glutamate receptors in primary cultures of rat cortical neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20210554&form=6&db=m Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20213245&form=6&db=m Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20214877&form=6&db=m Hemolysis induced by Bacillus cereus sphingomyelinase. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20215560&form=6&db=m PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20221277&form=6&db=m MLCK and PKC Involvements via Gi and Rho A Protein in Contraction by the Electrical Field Stimulation in Feline Esophageal Smooth Muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20223190&form=6&db=m Collaborative Study for the Standardisation of the Histamine Sensitizing Test in Mice and the CHO Cell-based Assay for the Residual Toxicity Testing of Acellular Pertussis Vaccines. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20223192&form=6&db=m Letter to the Editor: An Alternative Temperature-based Histamine-sensitisation Test for Absence of Residual Pertussis Toxin in Acellular Pertussis Vaccines. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20224433&form=6&db=m Role of nifedipine-sensitive sympathetic vasoconstriction in maintenance of high blood pressure in spontaneously hypertensive rats: effect of Gi-protein inactivation by pertussis toxin. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20226250&form=6&db=m The seroepidemiology of Bordetella pertussis in Israel--Estimate of incidence of infection. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20231290&form=6&db=m Pertussis toxin upregulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20233106&form=6&db=m Therapeutic effect of EDTA in experimental model of multiple sclerosis. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20233107&form=6&db=m Therapeutic approach by Aloe vera in experimental model of multiple sclerosis. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20237332&form=6&db=m Nociceptin Inhibits Uterine Contractions in Term-Pregnant Rats by Signaling Through Multiple Pathways. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20266385&form=6&db=m The failure of whooping-cough and adult sera to neutralise pertussis toxin. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20305288&form=6&db=m Bile acids regulate hepatic gluconeogenic genes and FXR via G-alpha-i protein coupled receptor(s) and the AKT pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20305784&form=6&db=m Homer1a-dependent crosstalk between NMDA and metabotropic glutamate receptors in mouse neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20307594&form=6&db=m An in vitro assay system as a potential replacement for the histamine sensitisation test for acellular pertussis based combination vaccines. diagnostic usage,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20331475&form=6&db=m Characterization of the migration of lung and blood T cells in response CXCL12 in a three-dimensional matrix. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20332211&form=6&db=m Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20335389&form=6&db=m EP1 Prostanoid Receptor Coupling to Gi/o Upregulates the Expression of Hypoxia-Inducible Factor-1{alpha} Through Activation of a Phosphoinositide-3 Kinase Signaling Pathway. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20335431&form=6&db=m Antibody response patterns to Bordetella pertussis antigens in vaccinated (primed) and unvaccinated (unprimed) young children with pertussis. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20348518&form=6&db=m Antibody response from whole-cell pertussis vaccine immunized Brazilian children against different strains of Bordetella pertussis. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20351316&form=6&db=m Neuropeptide Y Directly Inhibits Neuronal Activity in a Subpopulation of Gonadotropin-Releasing Hormone-1 Neurons via Y1 Receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20357056&form=6&db=m Synergic effect of genotype changes in pertussis toxin and pertactin on adaptation to an acellular pertussis vaccine in the murine intranasal challenge model. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20373111&form=6&db=m Evidence of Bordetella pertussis infection in vaccinated 1-year-old Danish children. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20375012&form=6&db=m The metabotropic glutamate receptor MGLU7, activates PLC, translocates MUNC-13-1 protein and potentiates glutamate release at cerebrocortical nerve terminals. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20375616&form=6&db=m Eosinophils utilize multiple chemokine receptors for chemotaxis to the parasitic nematode Strongyloides stercoralis. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20398738&form=6&db=m Kinetics of IL-17- and interferon-gamma-producing PLPp-specific CD4 T cells in EAE induced by coinjection of PLPp/IFA with pertussis toxin in SJL mice. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20399779&form=6&db=m Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20400686&form=6&db=m Evidence for a Role of Opioids in Epoxyeicosatrienoic Acid (EET)-induced Cardioprotection in Rat Hearts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20400782&form=6&db=m The role of calcium in modulating the reactivity of the smooth muscle cells during ischemia/reperfusion. Part 1. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20409940&form=6&db=m Role of potassium channels in stretch-promoted atrial natriuretic factor secretion. causal interaction,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20413718&form=6&db=m {beta}-adrenergic activation of electrogenic K+ and Cl- secretion in guinea pig distal colonic epithelium proceeds via separate cAMP signaling pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20414743&form=6&db=m Expression of Astrocytic Type 2 Angiotensin Receptor in Central Nervous System Inflammation Correlates With Blood-Brain Barrier Breakdown. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20421642&form=6&db=m Mouse and Human Eosinophils Degranulate in Response to Platelet-Activating Factor (PAF) and LysoPAF via a PAF-Receptor-Independent Mechanism: Evidence for a Novel Receptor. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20428440&form=6&db=m Mechanical stress and human aortic smooth muscle cell proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20435598&form=6&db=m Cellular Basis for Bimatoprost Effects on Human Conventional Outflow. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20435926&form=6&db=m Monocyte Trafficking to Hepatic Sites of Bacterial Infection Is Chemokine Independent and Directed by Focal Intercellular Adhesion Molecule-1 Expression. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20445128&form=6&db=m Expression and Signaling of G Protein-Coupled Estrogen Receptor (GPER) in Rat Sertoli Cells. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20447456&form=6&db=m The purinergic P2Y(13) receptor activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20452976&form=6&db=m Receptor-regulated interaction of activator of G-protein signaling-4 and Galphai. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20459460&form=6&db=m Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20460384&form=6&db=m Internalization of the human nicotinic acid receptor GPR109A is regulated by G(i), GRK2, and arrestin3. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20479129&form=6&db=m Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20487197&form=6&db=m Sphingosylphosphorylcholine inhibits melanin synthesis via pertussis toxin-sensitive MITF degradation. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20500551&form=6&db=m Selective expression and cellular localization of pro-inflammatory chemokine ligand/receptor pairs in the sciatic nerves of a severe murine experimental autoimmune neuritis model of Guillain-Barré syndrome. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20501312&form=6&db=m Evidence for the presence of cholinergic muscarinic receptors negatively linked to adenylate cyclase in the iris-ciliary body. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20501673&form=6&db=m S1P1 and VEGFR-2 form a signaling complex with extracellularly regulated kinase 1/2 and protein kinase C-alpha regulating ML-1 thyroid carcinoma cell migration. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20504402&form=6&db=m Effects of histamine on polyphosphoinositide metabolism in NG108-15 cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20504404&form=6&db=m Functional coupling of cerebral ?-aminobutyric acid (GABA)(B) receptor with adenylate cyclase system: effect of phaclofen. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20508003&form=6&db=m Antibody responses to pertussis toxin display different kinetics after clinical Bordetella pertussis infection than after vaccination with an acellular pertussis vaccine. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20508854&form=6&db=m Mass spectrometric analysis of multiple pertussis toxins and toxoids. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20513179&form=6&db=m Evaluation of activation of G proteins in response to thyroid stimulating hormone in thyroid gland cells from euthyroid and hyperthyroid cats. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20515023&form=6&db=m Identification and characterization of the carbohydrate ligands recognized by pertussis toxin via a glycan microarray and surface plasmon resonance. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20519319&form=6&db=m Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20530654&form=6&db=m Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20532047&form=6&db=m Naïve T cells re-distribute to the lungs of selectin ligand deficient mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20546729&form=6&db=m Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20551326&form=6&db=m Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20577889&form=6&db=m Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20580365&form=6&db=m Leukotriene B4 mediates vascular smooth muscle cell migration through ?v?3 integrin transactivation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20585374&form=6&db=m Incidence and reproduction numbers of pertussis: estimates from serological and social contact data in five European countries. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20590571&form=6&db=m The plant cannabinoid Delta9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20590577&form=6&db=m Neuroprotective potential of CB1 receptor agonists in an in vitro model of Huntington's disease. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20590584&form=6&db=m Microsomal prostaglandin E synthase-1 contributes to ischaemic excitotoxicity through prostaglandin E2 EP3 receptors. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20590644&form=6&db=m Beta(2)-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20597817&form=6&db=m An analysis of the occurrence of convulsions and death after childhood vaccination. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20599609&form=6&db=m Activation of neuromedin U type 1 receptor inhibits L-type Ca2+ channel currents via phosphatidylinositol 3-kinase-dependent protein kinase C epsilon pathway in mouse hippocampal neurons. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20599711&form=6&db=m Expression of functional GPR35 in human iNKT cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20605053&form=6&db=m Importance of CCL2-CCR2A/2B signaling for monocyte migration into spheroids of breast cancer-derived fibroblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20619695&form=6&db=m Development and migration of plasma cells in the mouse lymph node. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20621081&form=6&db=m Purinergic receptor-mediated morphological changes in microglia are transient and independent from inflammatory cytokine release. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20622165&form=6&db=m G?o represses insulin secretion by reducing vesicular docking in pancreatic beta-cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20627397&form=6&db=m Evidence for PI3K-dependent CXCR3 agonist-induced degranulation of human cord blood-derived mast cells. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20637762&form=6&db=m Impaired long-term maintenance and function of Bordetella pertussis specific B cell memory. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20653955&form=6&db=m Transformation by a nucleotide-activated P2Y receptor is mediated by activation of Galphai, Galphaq and Rho-dependent signaling pathways. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20654444&form=6&db=m Mechanisms Underlying the Inhibition of Soman on NMDA-stimulated [(3)H]Norepinephrine Release from Rat Cortical Slices, Role of Phospholipase C and Protein Kinase C. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20659530&form=6&db=m Leu27 insulin-like growth factor-II, an insulin-like growth factor-II analog, attenuates depolarization-evoked GABA release from adult rat hippocampal and cortical slices. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20663047&form=6&db=m Melatonin increases proliferation of cultured neural stem cells obtained from adult mouse subventricular zone. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20663860&form=6&db=m Oxytocin induces the migration of prostate cancer cells: involvement of the Gi-coupled signaling pathway. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20685741&form=6&db=m Prosurvival activity for airway neutrophils in severe asthma. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20691233&form=6&db=m Ghrelin and obestatin promote the allergic action in rat peritoneal mast cells as basic secretagogues. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20696781&form=6&db=m Modulation of N-type calcium currents by presynaptic imidazoline receptor activation in rat superior cervical ganglion neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20697956&form=6&db=m Thymoquinone-induced Neu4 sialidase activates NF?B in macrophage cells and pro-inflammatory cytokines in vivo. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20700542&form=6&db=m Paradoxical effect of pertussis toxin on the delayed hypersensitivity response to autoantigens in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20705094&form=6&db=m Sf9 cells: A versatile model system to investigate the pharmacological properties of G protein-coupled receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20705779&form=6&db=m ?2-adrenergic receptor-coupled phosphoinositide 3-kinase constrains cAMP-dependent increases in cardiac inotropy through phosphodiesterase 4 activation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20705903&form=6&db=m Role of cholinergic neurons in the motor effects of glucagon-like peptide-2 in mouse colon. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20709064&form=6&db=m Physiological evidence for ?3-adrenoceptor in frog (Rana esculenta) heart. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20713914&form=6&db=m Impaired 3',5'-cyclic adenosine monophosphate-mediated signaling in immediate early responsive gene X-1-deficient vascular smooth muscle cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20716524&form=6&db=m Regulation of the AGS3·G{alpha}i signaling complex by a seven-transmembrane span receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20718721&form=6&db=m Triplex real-time PCR assay for detection and differentiation of Bordetella pertussis and Bordetella parapertussis. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20720202&form=6&db=m Chemerin contributes to inflammation by promoting macrophage adhesion to VCAM-1 and fibronectin through clustering of VLA-4 and VLA-5. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20732256&form=6&db=m Toxicity of the specific antimuscarinic agent methoctramine and other non-specific anticholinergic drugs in human neuroblastoma cell lines in vitro. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20732875&form=6&db=m Testicular expression of Adora3i2 in Adora3 knockout mice reveals a role of mouse A3Ri2 and human A3Ri3 adenosine receptors in sperm. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20732992&form=6&db=m Rainbow trout somatostatin receptor subtypes SSTR1A, SSTR1B, and SSTR2 differentially activate the extracellular signal-regulated kinase and phosphatidylinositol 3-kinase signaling pathways in transfected cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20735427&form=6&db=m Advanced glycation end products (AGEs) activate mast cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20795791&form=6&db=m Prokineticin-1/endocrine gland-derived vascular endothelial growth factor is a survival factor for human multiple myeloma cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20797420&form=6&db=m Human RFamide-related peptide-1 diminishes cellular and integrated cardiac contractile performance. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20803555&form=6&db=m CB2 cannabinoid receptor targets mitogenic Gi protein - cyclin D1 axis in osteoblasts. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20804753&form=6&db=m Activation of human monocytes by a formyl peptide receptor 2-derived pepducin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20810258&form=6&db=m Expression and activation of matrix metalloproteinase-9 and NADPH oxidase in tissues and plasma of experimental autoimmune encephalomyelitis in mice. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20811645&form=6&db=m Centrally administered pertussis toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an EAE mouse model. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20813187&form=6&db=m P2Y(13) receptor is responsible for ADP-mediated degranulation in RBL-2H3 rat mast cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20814065&form=6&db=m Ghrelin signaling in human mesenteric arteries. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20816810&form=6&db=m Activation of phosphatidylinositol 3-kinase/Akt signaling pathway and endogenous nitric oxide are needed for the antiarrhythmic effect of centrally administered rilmenidine. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20833836&form=6&db=m Chemoattractant receptors and lymphocyte egress from extralymphoid tissue: changing requirements during the course of inflammation. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20837990&form=6&db=m Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20848601&form=6&db=m GluK1 inhibits calcium dependent and independent transmitter release at associational/commissural synapses in area CA3 of the hippocampus. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20852838&form=6&db=m PI3 kinase-dependent stimulation of platelet migration by stromal cell-derived factor 1 (SDF-1). therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20861350&form=6&db=m Lysophosphatidic acid inhibits CC chemokine ligand 5/RANTES production by blocking IRF-1-mediated gene transcription in human bronchial epithelial cells. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20864810&form=6&db=m Humoral immunity of dTap-IPV vaccine (REPEVAX(®)) administered one month after dT-IPV vaccine (REVAXIS(®)) in adults with unknown vaccination history. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20873483&form=6&db=m [Comparison of routine serological investigations performed in three different laboratories in Poland for the diagnosis of pertussis] diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20877573&form=6&db=m CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through bim-mediated intrinsic apoptosis. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20878241&form=6&db=m Fusion expression and immunogenicity of Bordetella pertussis PTS1-FHA protein: implications for the vaccine development. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20886687&form=6&db=m [Construction of the genetically attenuated bacteria Aordetella pertussis devoid of dermonecrotic toxin activity and producing modified nontoxic pertussis toxin form] ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20926668&form=6&db=m Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20939063&form=6&db=m Blockade of receptor-activated G(i) signaling in osteoblasts in vivo leads to site-specific increases in cortical and cancellous bone formation. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20943873&form=6&db=m Performance of commercial enzyme-linked immunosorbent assays for the detection of antibodies to Bordetella pertussis. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20952497&form=6&db=m Signaling pathways leading to phosphorylation of Akt and GSK-3{beta} by activation of cloned human and cerebral rat D2 and D3 receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20962269&form=6&db=m P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20974829&form=6&db=m IL-1R signaling is required to overcome the effects of pertussis toxin and for efficient infection or vaccination induced immunity against Bordetella pertussis. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20975313&form=6&db=m Endocytosis of Microperoxidase in Marginal Cells Is Mainly Regulated by RhoA Signaling Cascade, but Not by Rho-Associated Protein Kinase, Myosin Light-Chain Kinase and Myosin Phosphatase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20979115&form=6&db=m HDL and sphingosine-1-phosphate activate stat3 in prostate cancer DU145 cells via ERK1/2 and S1P receptors, and promote cell migration and invasion. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20980681&form=6&db=m Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20980685&form=6&db=m Follicular Fluid High-Density Lipoprotein (FF-HDL)-Associated Sphingosine 1-Phosphate (S1P) Promotes Human Granulosa Lutein Cell Migration via S1P Receptor Type 3 (S1PR3) and Small G Protein RAC1. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21029526&form=6&db=m Effect of vaccination on Bordetella pertussis strains, China. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21037077&form=6&db=m Commensal-Epithelial Signaling Mediated via Formyl Peptide Receptors. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21039419&form=6&db=m Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i) -dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21042851&form=6&db=m Expression and Signaling of Formyl-Peptide Receptors in the Brain. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21043546&form=6&db=m Tdap(5) vaccine (covaxis®): a review of its use as a single-booster immunization for the prevention of tetanus, diphtheria, and pertussis in children (aged ?4 years), adolescents, and adults. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21047945&form=6&db=m Apelin Decreases Lipolysis via Gq, Gi, and AMPK-Dependent Mechanisms. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21051874&form=6&db=m Inhibition of Rho-Kinase Abrogates Migration of Human Transitional Cell Carcinoma Cells: Results of an in vitro Study. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21069406&form=6&db=m What to do and what not to do in serological diagnosis of pertussis: recommendations from EU reference laboratories. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21070624&form=6&db=m Comparative genomics of prevaccination and modern Bordetella pertussis strains. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21070854&form=6&db=m WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21088225&form=6&db=m Different effects of the different natural CC chemokine receptor 2b ligands on beta-arrestin recruitment, G?i signaling, and receptor internalization. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21091778&form=6&db=m Pertussis serology: assessment of IgG anti-PT ELISA for replacement of the CHO cell assay. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21106238&form=6&db=m Neuromedin U inhibits T-type Ca2+ channel currents and decreases membrane excitability in small dorsal root ganglia neurons in mice. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21106540&form=6&db=m C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21106854&form=6&db=m Dendritic cells distinguish individual chemokine signals through CCR7 and CXCR4. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21115396&form=6&db=m Pertussis toxin permeabilization enhances the traversal of Escherichia coli K1, macrophages, and monocytes in a cerebral endothelial barrier model in vitro. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21118968&form=6&db=m Sphingosine-1-phosphate activates the AKT pathway to protect small intestines from radiation-induced endothelial apoptosis. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21126059&form=6&db=m Bombyx adipokinetic hormone receptor activates extracellular signal-regulated kinase 1 and 2 via G protein-dependent PKA and PKC but ?-arrestin-independent pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21128903&form=6&db=m Wnt3a stimulation elicits G-protein-coupled receptor properties of mammalian Frizzled proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21130421&form=6&db=m Induction of polyclonal CD8+ T cell activation and effector function by Pertussis toxin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21131397&form=6&db=m Paradoxical attenuation of {beta}2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase. causal interaction,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21143597&form=6&db=m Non-additive potentiation of glutamate release by phorbol esters and metabotropic mGlu7 receptor in cerebrocortical nerve terminals. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21144840&form=6&db=m Mitocryptide-2, a neutrophil-activating cryptide, is a specific endogenous agonist for formyl-peptide receptor-like 1. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21147284&form=6&db=m Phosphate-dependent stimulation of MGP and OPN expression in osteoblasts via the ERK1/2 pathway is modulated by calcium. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21152071&form=6&db=m Seroprevalence of pertussis in The Netherlands: evidence for increased circulation of Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21154445&form=6&db=m Metabotropic ?-aminobutyric acid (GABA(B)) receptors modulate feeding behavior in the calcisponge Leucandra aspera. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21156170&form=6&db=m Further analyses of mechanisms underlying the antinociceptive effect of the triterpene 3?, 6?, 16?-trihydroxylup-20(29)-ene in mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21167293&form=6&db=m Anti-proliferative effect of a putative endocannabinoid, 2-arachidonylglyceryl ether in prostate carcinoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21167820&form=6&db=m DIgLONs inhibit initiation of neurite outgrowth from forebrain neurons via an IgLON-containing receptor complex. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21168503&form=6&db=m Berberine possesses muscarinic agonist-like properties in cultured rodent cardiomyocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21185823&form=6&db=m Role of prostanoid IP and EP receptors in mediating vasorelaxant responses to PGI2 analogues in rat tail artery: Evidence for Gi/o modulation via EP3 receptors. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21187178&form=6&db=m Identifying long-term memory B-cells in vaccinated children despite waning antibody levels specific for Bordetella pertussis proteins. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21193663&form=6&db=m Role of the cell wall microenvironment in expression of a heterologous SpaP-S1 fusion protein by Streptococcus gordonii. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21198551&form=6&db=m Antagonist interaction with the human 5-HT(7) receptor mediates the rapid and potent inhibition of non-G-protein-stimulated adenylate cyclase activity: a novel GPCR effect. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21209077&form=6&db=m Opioid-induced Down-Regulation of RGS4: ROLE OF UBIQUITINATION AND IMPLICATIONS FOR RECEPTOR CROSS-TALK. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21209857&form=6&db=m Repetitive pertussis toxin promotes development of regulatory T cells and prevents central nervous system autoimmune disease. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21211579&form=6&db=m Outer membrane vesicles obtained from Bordetella pertussis Tohama expressing the lipid A deacylase PagL as a novel acellular vaccine candidate. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21214543&form=6&db=m Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21220323&form=6&db=m Augmented glucose-induced insulin release in mice lacking G(o2), but not G(o1) or G(i) proteins. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21228337&form=6&db=m Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21244430&form=6&db=m Unmasking of LPA(1) receptor-mediated migration response to lysophosphatidic acid by interleukin-1?-induced attenuation of Rho signaling pathways in rat astrocytes. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21244897&form=6&db=m G-protein control of cardiac potassium channels. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21248122&form=6&db=m Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21255008&form=6&db=m Expression and agonist responsiveness of CXCR3 variants in human T lymphocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21255617&form=6&db=m Heterotrimeric G?(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21258176&form=6&db=m Involvement of protein kinase C and RhoA in protease-activated receptor 1-mediated F-actin reorganization and cell growth in rat cardiomyocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21270409&form=6&db=m Anaphylaxis and mortality induced by treatment of mice with anti-VLA-4 antibody and pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21279210&form=6&db=m Simulation of generation-collection experiments with homogeneous kinetics: application to electrochemical investigation of superoxide radical anion generation by osteoclasts on bone. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21292998&form=6&db=m TNF-{alpha} potentiates lysophosphatidic acid-induced COX-2 expression via PKD in human colonic myofibroblasts. causal interaction,therapeutic application,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21300668&form=6&db=m Equol-Stimulated Mitochondrial Reactive Oxygen Species Activate Endothelial Nitric Oxide Synthase and Redox Signaling in Endothelial Cells: Roles for F-Actin and GPR30. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21302283&form=6&db=m LPA(1) -induced migration requires nonmuscle myosin II light chain phosphorylation in breast cancer cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21323580&form=6&db=m Dynamic Mass Redistribution as a Means to Measure and Differentiate Signaling via Opioid and Cannabinoid Receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21325488&form=6&db=m Fast, antigen-saving multiplex immunoassay to determine levels and avidity of mouse serum antibodies to pertussis, diphtheria, and tetanus antigens. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21329754&form=6&db=m Activation of M3 muscarinic receptors inhibits T-type Ca(2+) channel currents via pertussis toxin-sensitive novel protein kinase C pathway in small dorsal root ganglion neurons. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21351814&form=6&db=m Spotlight on Tdap? vaccine (Covaxis®) as a single-booster immunization for the prevention of tetanus, diphtheria, and pertussis: in children (aged ?4 years), adolescents, and adults. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21366505&form=6&db=m High dose combination pertussis toxin induces autoimmune inner ear disease in Sprague-Dawley rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21366548&form=6&db=m A(2B) adenosine receptors inhibit superoxide production from mitochondrial complex I in rabbit cardiomyocytes via a mechanism sensitive to Pertussis toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21370481&form=6&db=m Metabotropic ?-aminobutyric acid (GABA(B) ) receptors modulate feeding behavior in the calcisponge Leucandra aspera. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21374700&form=6&db=m Rhes and AGS1/Dexras1 affect signaling by dopamine D1 receptors through adenylyl cyclase. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21396900&form=6&db=m Appearance of Fim3 and ptxP3-Bordetella pertussis strains, in two regions of Sweden with different vaccination programs. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21406184&form=6&db=m A farnesylated G-protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets: Regulation by pertussis toxin and PGE(2). causal interaction,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21412239&form=6&db=m Non-activated APJ suppresses the angiotensin II type 1 receptor, whereas apelin-activated APJ acts conversely. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21418369&form=6&db=m Crawling phagocytes recruited in the brain vasculature after pertussis toxin exposure through IL6, ICAM1, and ITG?M. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21419195&form=6&db=m Opposite modulation of astroglial proliferation by adenosine 5'-O-(2-thio)-diphosphate tetralithium and 2-methylthioadenosine-5'-diphosphate trisodium: mechanisms involved. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21422963&form=6&db=m Seroprevalence of Bordetella pertussis Antibody in Children and Adolescents in China. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21423378&form=6&db=m Pertussis Toxin Nullifies the Depolarization of the Membrane Potential and the Stimulation of the Rapid Phase of Ca Entry Through L-type Calcium Channels that are Produced by Follicle Stimulating Hormone in 10- to 12-Day-Old Rat Sertoli Cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21425331&form=6&db=m GPRC6A Mediates Responses to Osteocalcin in ?-Cells In Vitro and Pancreas In Vivo. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21426744&form=6&db=m [Effects of matrix metalloproteinase-9 inhibitor in Lewis rats with experimental autoimmune myocarditis.] causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21429300&form=6&db=m cAMP antagonizes ERK-dependent antiapoptotic action of insulin. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21430219&form=6&db=m Attenuated Bordetella pertussis Vaccine Candidate BPZE1 Promotes Human Dendritic Cell CCL21-Induced Migration and Drives a Th1/Th17 Response. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21435724&form=6&db=m The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21437670&form=6&db=m Disparity in Fc?RI-Induced Degranulation of Primary Human Lung and Skin Mast Cells Exposed to Adenosine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21438119&form=6&db=m The occupancy of endothelial protein C receptor by its ligand modulates the par-1 dependent signaling specificity of coagulation proteases. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21441844&form=6&db=m Nicotinic Acid Inhibits Glucose-Stimulated Insulin Secretion Via the G Protein-Coupled Receptor PUMA-G in Murine Islet ? Cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21447002&form=6&db=m ?(2) -Adrenoceptors activate noradrenaline-mediated glycogen turnover in chick astrocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21447485&form=6&db=m Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21449079&form=6&db=m [Production of pertussis toxin by Bordetella pertussis strains isolated from patients with whooping cough]. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21457229&form=6&db=m NATRIURETIC PEPTIDE RECEPTOR-C UNDERPINS THE DISPARATE REGULATION OF ENDOTHELIAL AND VASCULAR SMOOTH MUSCLE CELL PROLIFERATION BY C-TYPE NATRIURETIC PEPTIDE. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21458443&form=6&db=m N-acetylated Proline-Glycine-Proline induced G-protein dependent chemotaxis of neutrophils is independent of CXCL8 release. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21461565&form=6&db=m Fibronectin increases RhoA activity through inhibition of PKA in the human gastric cancer cell line SGC-7901. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21464955&form=6&db=m Studies on prn variation in the mouse model and comparison with epidemiological data. causal interaction,diagnostic usage,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21478254&form=6&db=m Photolysis of Caged Sphingosine-1-phosphate Induces Barrier Enhancement and Intracellular Activation of Lung Endothelial Cell Signaling Pathways. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21480213&form=6&db=m Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21480366&form=6&db=m ER-resident G(i2) protein controls Sar1 translocation onto the ER during budding of transport vesicles. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21488197&form=6&db=m Effect of pertussis toxin and herbimycin A on proteinase-activated receptor 2-mediated cyclooxygenase 2 expression in Helicobacter pylori-infected gastric epithelial AGS cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21508166&form=6&db=m Antibodies recognizing protective pertussis toxin epitopes are preferentially elicited by natural infection versus acellular immunization. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21515255&form=6&db=m Regulation of PI3K/Akt signaling by N-desmethylclozapine through activation of ?-opioid receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21515378&form=6&db=m ET-1 induced Elevation of intracellular calcium in clonal neuronal and embryonic kidney cells involves endogenous endothelin-A receptors linked to phospholipase C through G?(q/11). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21519925&form=6&db=m Non-phosphorylated FTY720 Induces Apoptosis of Human Microglia by Activating SREBP2. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21533103&form=6&db=m Bordetella pertussis infection exacerbates influenza virus infection through pertussis toxin-mediated suppression of innate immunity. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21539863&form=6&db=m Signalling pathway of goldfish melanin-concentrating hormone receptors 1 and 2. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21547533&form=6&db=m Orexins/Hypocretins Acting at G(i) Protein-Coupled OX (2) Receptors Inhibit Cyclic AMP Synthesis in the Primary Neuronal Cultures. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21554577&form=6&db=m Inhibition of prolactin release by gonadotropin-releasing hormone-associated Peptide in benign, dopamine-sensitive and in malignant, dopamine-resistant pituitary tumors. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21556017&form=6&db=m Most B cells in non-lymphoid tissues are naïve. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21557728&form=6&db=m Facilitation of transmitter release from rat sympathetic neurons via presynaptic P2Y(1) receptors. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21558316&form=6&db=m Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21562303&form=6&db=m Calcium-sensing receptor modulates extracellular Ca2+ entry via TRPC-encoded receptor-operated channels in human aortic smooth muscle cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21566946&form=6&db=m Muscarinic acetylcholine and histamine-receptor mediated calcium mobilization and cell-growth in human ovarian-cancer cells. causal interaction,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21571006&form=6&db=m Accelerated maternal responding following intra-VTA pertussis toxin treatment. ongoing research,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21585522&form=6&db=m Melatonin inhibits insulin secretion in rat insulinoma ?-cells (INS-1) heterologously expressing the human melatonin receptor isoform MT2. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21605080&form=6&db=m Gadolinium inhibits prostate cancer PC3 cell migration and suppresses osteoclast differentiation in vitro. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21618533&form=6&db=m Hyposmotic stress causes ATP release and stimulates Na, K-ATPase activity in porcine lens. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21620797&form=6&db=m Modulation of N-type Ca²? currents by moxonidine via imidazoline I? receptor activation in rat superior cervical ganglion neurons. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21627585&form=6&db=m Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21632882&form=6&db=m p2y5/LPA6 attenuates LPA1-mediated VE-cadherin translocation and cell-cell dissociation through G12/13 protein-Src-Rap1. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21647370&form=6&db=m SNP-based typing: a useful tool to study Bordetella pertussis populations. causal interaction,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21669247&form=6&db=m Impact of infant and preschool pertussis vaccinations on memory B-cell responses in children at 4 years of age. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21677109&form=6&db=m Immunization of Teenagers with a Fifth Dose of Reduced DTaP-IPV Induces High Levels of Pertussis Antibodies with a Significant Increase in Opsonophagocytic Activity. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21688304&form=6&db=m Thymoquinone-induced platelet apoptosis. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21691079&form=6&db=m Activation of growth hormone secretagogue type 1a receptor inhibits T-type Ca2+ channel currents through pertussis toxin-sensitive novel protein kinase C pathway in mouse spermatogenic cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21698257&form=6&db=m SCFAs induce mouse neutrophil chemotaxis through the GPR43 receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21702922&form=6&db=m Lymph node-derived donor encephalitogenic CD4+ T cells in C57BL/6 mice adoptive transfer experimental autoimmune encephalomyelitis highly express GM-CSF and T-bet. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21703282&form=6&db=m Rapid signaling responses in Sertoli cell membranes induced by follicle stimulating hormone and testosterone: Calcium inflow and electrophysiological changes. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21703864&form=6&db=m Myeloid cells migrate in response to IL-24. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21705677&form=6&db=m Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21708014&form=6&db=m Potential role and mechanism of IFN-gamma inducible protein-10 on receptor activator of nuclear factor kappa-B ligand (RANKL) expression in rheumatoid arthritis. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21708247&form=6&db=m NADPH-oxidase-dependent reactive oxygen species mediate EGFR transactivation by FPRL1 in WKYMVm-stimulated human lung cancer cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21713663&form=6&db=m In the developing hippocampus kainate receptors control the release of GABA from mossy fiber terminals via a metabotropic type of action. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21718754&form=6&db=m Inhibitors of diacylglycerol metabolism reduce time to the onset of glutamate release potentation by mGlu7 receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21719794&form=6&db=m Gi-coupled GABAB Receptors Cross-Regulate Phospholipase C and Calcium in Airway Smooth Muscle. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21723247&form=6&db=m Calpain inhibitors stimulate phagocyte functions via activation of human formyl peptide receptors. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21734188&form=6&db=m Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21740523&form=6&db=m The ins and outs of pertussis toxin. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21768093&form=6&db=m Distinct kinetic and spatial patterns of PKC- and EGFR-dependent activation of extracellular signal-regulated kinases 1 and 2 by humane nicotinic acid receptor GPR109A. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21769916&form=6&db=m Sphingosine Kinase 1/S1P Pathway Involvement in the GDNF-Induced GAP43 Transcription. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21781791&form=6&db=m Chronic ethanol promotes the neuronal differentiation of NG108-15 cells independently of toxin-sensitive G-proteins. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21782823&form=6&db=m EUVAC.NET collaborative study: Evaluation and standardisation of serology for diagnosis of pertussis. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21784058&form=6&db=m Guanine-induced inhibition of renal Na(+)-ATPase activity: Evidence for the involvement of the Gi protein-coupled receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21803088&form=6&db=m Different IgG-subclass distributions after whole-cell and acellular pertussis infant primary vaccinations in healthy and pertussis infected children. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21803969&form=6&db=m Rimonabant, a CB1 Inverse Agonist, Inhibits Hepatocyte Lipogenesis by Activating LKB1 and AMPK Axis Downstream of G{alpha}i/o Inhibition. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21807058&form=6&db=m Investigation of effects of different commercial source of bovine serum albumin on the binding of pertussis toxin to the glycoprotein fetuin. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21832245&form=6&db=m Aldosterone stimulates vacuolar H+-ATPase activity in renal acid-secretory intercalated cells mainly via a protein kinase C dependent pathway. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21850025&form=6&db=m Autocrine Regulation of Re-Epithelialization After Wounding by Chemokine Receptors CCR1, CCR10, CXCR1, CXCR2, and CXCR3. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21851339&form=6&db=m 5'-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21855138&form=6&db=m CART peptide stimulation of G protein-mediated signaling in differentiated PC12 Cells: Identification of PACAP 6-38 as a CART receptor antagonist. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21864502&form=6&db=m Fluorescence spectroscopy studies of HEK293 cells expressing DOR-G(i)1? fusion protein; the effect of cholesterol depletion. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21864554&form=6&db=m Hydrogen peroxide signaling mediates DHEA-induced vascular endothelial cell proliferation. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21864569&form=6&db=m Seroprevalence of antibodies to pertussis and diphtheria among healthy adults in China. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21871564&form=6&db=m Lysophosphatidic acid increases soluble ST2 expression in mouse lung and human bronchial epithelial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21872447&form=6&db=m Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21878527&form=6&db=m Xamoterol impairs hippocampus-dependent emotional memory retrieval via Gi/o-coupled ?2-adrenergic signaling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21903117&form=6&db=m Chronic treatment with the opioid antagonist naltrexone favours the coupling of spinal cord ?-opioid receptors to G?z protein subunits. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21918105&form=6&db=m Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21932398&form=6&db=m Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21936770&form=6&db=m The G Protein-coupled Receptor CysLT1 Mediates Chemokine-like Effects and Prolongs Survival in Chronic Lymphocytic Leukemia. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21936876&form=6&db=m Neurotensin inhibits background K+ channels and facilitates glutamatergic transmission in rat spinal cord dorsal horn. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21940464&form=6&db=m Novel multitarget real-time PCR assay for rapid detection of Bordetella species in clinical specimens. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21945754&form=6&db=m [Development of a time-resolved fluoroimmunoassay for detecting S1 subunit of pertussis toxin and its application]. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21945811&form=6&db=m Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21947268&form=6&db=m Adjuvant immunotherapy of C6 glioma in rats with pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21949112&form=6&db=m Heterotrimeric Gi/Go proteins modulate endothelial TLR signaling independent of the MyD88-dependent pathway. causal interaction,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21949652&form=6&db=m Analysis of behavior and trafficking of dendritic cells within the brain during toxoplasmic encephalitis. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21953499&form=6&db=m Enhanced immune response against pertussis toxoid by IgA-loaded chitosan-dextran sulfate nanoparticles. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21961942&form=6&db=m Functional analysis of guinea pig ?1-adrenoceptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21964035&form=6&db=m Differences in the genomic content of Bordetella pertussis isolates before and after introduction of pertussis vaccines in four European countries. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21966394&form=6&db=m G?i)- and G?i3-specific regulation of voltage-dependent L-type calcium channels in cardiomyocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21976502&form=6&db=m Stress and glucocorticoids impair memory retrieval via ?2-adrenergic, Gi/o-coupled suppression of cAMP signaling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22000164&form=6&db=m Specificity and detection limit of a dermal temperature histamine sensitization test for absence of residual pertussis toxin in vaccines. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22010988&form=6&db=m Identification of Novel Competing ?(2)AR Phospho-Extracellular Signal Regulated Kinase 1/2 Signaling Pathways in Human Trabecular Meshwork Cells. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22016541&form=6&db=m Resolving TRPV1- and TNF-?-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22023408&form=6&db=m GABAB receptors-associated proteins: potential drug targets in neurological disorders? therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22031472&form=6&db=m ?-Opioid receptors stimulate the metabolic sensor AMP-activated protein kinase through coincident signaling with G(q/11)-coupled receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22038817&form=6&db=m Unbinding forces of single pertussis toxin-antibody complexes measured by atomic force spectroscopy correlate with their dissociation rates determined by surface plasmon resonance. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22069594&form=6&db=m Toxins-useful biochemical tools for leukocyte research. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22069745&form=6&db=m G(i/o) Protein-Dependent and -Independent Actions of Pertussis Toxin (PTX). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22074645&form=6&db=m Alpha-cobratoxin inhibits T-type calcium currents through muscarinic M4 receptor and G?-protein ?? subunits-dependent protein kinase A pathway in dorsal root ganglion neurons. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22076776&form=6&db=m The mechanism of MAP kinase activation under acidic condition in feline esophageal smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22083878&form=6&db=m The presumed atypical chemokine receptor CXCR7 signals through G(i/o) proteins in primary rodent astrocytes and human glioma cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22087741&form=6&db=m Ionizing Radiation Increases Adhesiveness of Human Aortic Endothelial Cells via a Chemokine-Dependent Mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22090294&form=6&db=m [Development and optimization of an in-house PCR method for molecular diagnosis of pertussis]. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22093381&form=6&db=m Pro-inflammatory effector Th cells transmigrate through anti-inflammatory environments into the murine fetus. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22116688&form=6&db=m Comparative study of different sources of pertussis toxin (PT) as coating antigens in IgG anti-PT enzyme-linked immunosorbent assays. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22125314&form=6&db=m Virus stimulation of human mast cells results in the recruitment of CD56+ T cells by a mechanism dependent on CCR5 ligands. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22131356&form=6&db=m Prospective evaluation of an Australian pertussis toxin IgG and IgA enzyme immunoassay. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22140501&form=6&db=m A knockout mutation of a constitutive GPCR in Tetrahymena decreases both G-protein activity and chemoattraction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22155625&form=6&db=m Inhibitory effects of C4a on chemoattractant and secretagogue functions of the other anaphylatoxins via Gi protein-adenylyl cyclase inhibition pathway in mast cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22169298&form=6&db=m [Biological behavior of SDF-1/CXCR4 in patients with myelodysplastic syndrome]. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22171040&form=6&db=m The chemokine CCL2 increases Nav1.8 sodium channel activity in primary sensory neurons through a G??-dependent mechanism. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22190729&form=6&db=m G(o) activation is required for both appetitive and aversive memory acquisition in Drosophila. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22207084&form=6&db=m Rapid membrane responses to dihydrotestosterone are sex dependent in growth plate chondrocytes. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22239975&form=6&db=m LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and Gi? dependent PI-3kinase signalling. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22243639&form=6&db=m The seroepidemiology of pertussis in NSW: fluctuating immunity profiles related to changes in vaccination schedules. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22245502&form=6&db=m Naloxone in ultralow concentration restores endomorphin-1-evoked Ca(2+) signaling in lipopolysaccharide pretreated astrocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22247602&form=6&db=m Butyrate enhancement of inteleukin-1? production via activation of oxidative stress pathways in lipopolysaccharide-stimulated THP-1 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22266325&form=6&db=m N-arachidonoyl glycine induces macrophage apoptosis via GPR18. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22282525&form=6&db=m Differential Signalling by Splice Variants of the Human Free Fatty Acid Receptor, GPR120. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22286231&form=6&db=m Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22293463&form=6&db=m Selection and emergence of pertussis toxin promoter ptxP3 allele in the evolution of Bordetella pertussis. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22307674&form=6&db=m Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca2+ channel activity through phosphatases in heart failure. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22313629&form=6&db=m Prevalence of Bordetella pertussis and Bordetella parapertussis infections in Tunisian hospitalized infants: results of a 4-year prospective study. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22337890&form=6&db=m Inhibition of chemokine (C-X-C motif) ligand 12/chemokine (C-X-C motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22339216&form=6&db=m Bacteria and their toxins tamed for immunotherapy. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22342543&form=6&db=m A diet enriched with cocoa prevents IgE synthesis in a rat allergy model. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22349504&form=6&db=m Label-free impedance responses of endogenous and synthetic chemokine receptor CXCR3 agonists correlate with G(i)-protein pathway activation. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22354966&form=6&db=m Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22357646&form=6&db=m Age-related differences in patterns of increased Bordetella pertussis antibodies. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22361510&form=6&db=m Possible Involvement of Sphingosine-1-Phosphate/G(i)/RhoA Pathways in Adherence of Eosinophils to Pulmonary Endothelium. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22362083&form=6&db=m Regulatory mechanisms underlying the modulation of GIRK1/GIRK4 heteromeric channels by P2Y receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22375000&form=6&db=m GRK2-mediated trans-phosphorylation contributes to the loss of function of mu opioid receptors induced by neuropeptide FF (NPFF2) receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22383676&form=6&db=m Gene Polymorphism in Toll-like Receptor 4: Effect on Antibody Production and Persistence After Acellular Pertussis Vaccination During Adolescence. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22394609&form=6&db=m Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22411356&form=6&db=m G?(i2) signaling: friend or foe in cardiac injury and heart failure? causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22419424&form=6&db=m The regulatory effect of liuwei dihuang pills on cytokines in mice with experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22422617&form=6&db=m Low-Density Lipoprotein Induced Expression of Connective Tissue Growth Factor via Transactivation of Sphingosine 1-Phosphate Receptors in Mesangial Cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22429572&form=6&db=m Involvement of the peroxisome proliferator-activated receptor (PPAR) alpha in vascular response of endocannabinoids in the bovine ophthalmic artery. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22438472&form=6&db=m Contribution of the extracellular cAMP-adenosine pathway to dual coupling of ?2-adrenoceptors to Gs and Gi proteins in mouse skeletal muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22449718&form=6&db=m The non-genomic rapid acidification in peripheral T cells by progesterone depends on intracellular calcium increase and not on Na+/H+-exchange inhibition. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22484643&form=6&db=m Sar1 translocation onto the ER-membrane for vesicle budding has different pathways for promotion and suppression of ER-to-Golgi transport mediated through H89-sensitive kinase and ER-resident G protein. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22492651&form=6&db=m Evolving insights regarding mechanisms for the inhibition of insulin release by norepinephrine and heterotrimeric G proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22504059&form=6&db=m Moderate hypothermia attenuates ?(1)-adrenoceptor-mediated contraction in isolated rat aorta: the role of the endothelium. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22524455&form=6&db=m Construction of Bordetella pertussis strains with enhanced production of genetically-inactivated Pertussis Toxin and Pertactin by unmarked allelic exchange. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22525519&form=6&db=m Blockade of endothelial Gi protein enhances early engraftment in intraportal cell transplant to mouse liver. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22527330&form=6&db=m Bordetella Pertussis Toxin does not induce the release of pro-inflammatory cytokines in human whole blood. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22535965&form=6&db=m Interaction with caveolin-1 modulates G protein coupling of mouse ?3-adrenoceptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22551306&form=6&db=m Mechanistic insight into pertussis toxin and lectin signaling using T cells engineered to express a CD8?/CD3? chimeric receptor. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22558249&form=6&db=m Increased population prevalence of low pertussis toxin antibody levels in young children preceding a record pertussis epidemic in Australia. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22570732&form=6&db=m Co-stimulation of PAFR and CD36 is required for oxLDL-induced human macrophages activation. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22573829&form=6&db=m Estrogen inhibits D2S receptor-regulated Gi3 and Gs protein interactions to stimulate prolactin production and cell proliferation in lactotropic cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22609106&form=6&db=m Workshop on Animal free Detection of Pertussis Toxin in Vaccines--Alternatives to the Histamine Sensitisation Test. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22652417&form=6&db=m CXCL10 contributes to p38-mediated apoptosis in primary T lymphocytes in vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22672634&form=6&db=m Evidence of the receptor-mediated influence of melatonin on pancreatic glucagon secretion via the G?q protein-coupled and PI3K signaling pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22673325&form=6&db=m Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22706104&form=6&db=m [The discovery of neuromedin U and its pivotal role in the central regulation of energy homeostasis]. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22708658&form=6&db=m Modulation of Central Control of Hypotensive Effects by Neuropeptide Y is Mediated through RSK Induced Activation of Endothelial Nitric Oxide Synthase. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22722599&form=6&db=m The Major Leukocyte Chemotactic and Activating Factors in the Mouse Gut Lumen Are Not N-Formylpeptide Receptor 1 Agonists. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22754560&form=6&db=m mADP-RTs: versatile virulence factors from bacterial pathogens of plants and mammals. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22772360&form=6&db=m Riboflavin: Inhibitory Effects on Receptors, G-Proteins, and Adenylate Cyclase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22774996&form=6&db=m Urocortin 3 elevates cytosolic calcium in nucleus ambiguus neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22776956&form=6&db=m Cannabinoid Receptor Activation Correlates with the Proapoptotic Action of the ?2-Adrenergic Agonist (R,R')-4-Methoxy-1-Naphthylfenoterol in HepG2 Hepatocarcinoma Cells. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22787194&form=6&db=m Two-Component Cluster Analysis of a Large Serodiagnostic Database for Specificity of Increases of IgG Antibodies against Pertussis Toxin in Paired Serum Samples and of Absolute Values in Single Serum Samples. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22790215&form=6&db=m Glycochenodeoxycholic acid promotes proliferation of intestinal epithelia via reduction of cyclic AMP and increase in H2AX phosphorylation after exposure to ?-rays. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22806273&form=6&db=m Role of pertussis toxin-sensitive G-protein, K(+) channels, and voltage-gated Ca (2+) channels in the antinociceptive effect of inosine. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22815286&form=6&db=m Endothelial CD47 Promotes Vascular Endothelial-Cadherin Tyrosine Phosphorylation and Participates in T Cell Recruitment at Sites of Inflammation In Vivo. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22820166&form=6&db=m Ultra-low dose naloxone restores the antinocicepitve effect of morphine in PTX-treated rats: Association of IL-10 upregulation in the spinal cord. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22820196&form=6&db=m Inhibition of lipid phosphate phosphatase activity by VPC32183 suppresses the ability of diacylglycerol pyrophosphate to activate ERK(1/2) MAP kinases. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22822456&form=6&db=m Monoclonal antibodies and toxins--a perspective on function and isotype. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22823236&form=6&db=m Multiple recurrences in melanin-protein-induced uveitis in the rat. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22825617&form=6&db=m The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22863658&form=6&db=m A fully liquid DTaP-IPV-Hep B-PRP-T hexavalent vaccine for primary and booster vaccination of healthy Mexican children. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22869731&form=6&db=m Strategies to alleviate original antigenic sin responses to influenza viruses. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22869906&form=6&db=m NK Cells Regulate CD8+ T Cell Priming and Dendritic Cell Migration during Influenza A Infection by IFN-? and Perforin-Dependent Mechanisms. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22870296&form=6&db=m Identification and Characterization of ZEL-H16 as a Novel Agonist of the Histamine H(3) Receptor. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22870943&form=6&db=m Active induction of experimental autoimmune encephalomyelitis by MOG35-55 peptide immunization is associated with differential responses in separate compartments of the choroid plexus. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22872320&form=6&db=m Secretion of Matrix Metalloproteinase-9 from Astrocytes by Inhibition of Tonic P2Y(14)-Receptor-Mediated Signal(s). causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22892100&form=6&db=m The seroepidemiology of Immunoglobulin G antibodies against pertussis toxin in China: a cross sectional study. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22900098&form=6&db=m Pertussis Toxin, an Inhibitor of G(?i) PCR, Inhibits Bile Acid- and Cytokine-Induced Apoptosis in Primary Rat Hepatocytes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22909320&form=6&db=m Rapid detection of the recently emerged Bordetella pertussis strains with the ptxP3 pertussis toxin promoter allele by real-time PCR. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22915988&form=6&db=m A Novel Carbamoyloxy Arylalkanoyl Arylpiperazine Compound (SKL-NP) Inhibits Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Currents in Rat Dorsal Root Ganglion Neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22918864&form=6&db=m Direct molecular typing of Bordetella pertussis from clinical specimens submitted for diagnostic quantitative (real-time) PCR. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22921807&form=6&db=m RGS2 overexpression or G(i) inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22931522&form=6&db=m Reduced-antigen, combined diphtheria, tetanus and acellular pertussis vaccine, adsorbed (boostrix®): a review of its properties and use as a single-dose booster immunization. diagnostic usage,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22933780&form=6&db=m The C-Type Natriuretic Peptide Induces Thermal Hyperalgesia through a Noncanonical G??-dependent Modulation of TRPV1 Channel. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22935082&form=6&db=m Pro-fibrotic processes in human lung fibroblasts are driven by an autocrine/paracrine endothelinergic system. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22936789&form=6&db=m The Essential Role of Gi?2 in Prostate Cancer Cell Migration. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22956654&form=6&db=m Antibody responses to individual Bordetella pertussis fimbrial antigens Fim2 or Fim3 following immunisation with five component acellular pertussis vaccine or disease. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22966424&form=6&db=m The Role of M. leprae Hsp65 Protein and Peptides in the Pathogenesis of Uveitis. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22981763&form=6&db=m Differences in avidity of IgG antibodies to pertussis toxin after acellular pertussis booster vaccination and natural infection. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22982338&form=6&db=m A Novel Nutrient Sensing Mechanism Underlies Substrate-induced Regulation of Monocarboxylate Transporter 1. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22993071&form=6&db=m Connective tissue and its growth factor CTGF distinguish the morphometric and molecular remodeling of the bladder in a model of neurogenic bladder. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22994538&form=6&db=m Preliminary studies on the development of IgA-loaded chitosan-dextran sulphate nanoparticles as a potential nasal delivery system for protein antigens. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23015017&form=6&db=m A continuous, fluorescence-based assay of ?-opioid receptor activation in AtT-20 cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23022630&form=6&db=m Assessment of IgG avidity against pertussis toxin and filamentous hemagglutinin via an adapted enzyme-linked immunosorbent assay (ELISA) using ammonium thiocyanate. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23026169&form=6&db=m Ultra-low-dose naloxone enhances the antinociceptive effect of morphine in PTX-treated rats: regulation on global histone methylation. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23027529&form=6&db=m Pertussis toxin exacerbates and prolongs airway inflammatory responses during Bordetella pertussis infection. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23029123&form=6&db=m Roles of dopamine 2 receptor isoforms and g proteins in ethanol regulated prolactin synthesis and lactotropic cell proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23029513&form=6&db=m Small mutations in Bordetella pertussis are associated with selective sweeps. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23041148&form=6&db=m Contrary effects of sphingosine-1-phosphate on expression of ?-smooth muscle actin in transforming growth factor ?1-stimulated lung fibroblasts. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23058160&form=6&db=m Seroprevalence of Bordetella pertussis antibodies to pertussis toxin among healthy children. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23061054&form=6&db=m Bacterial toxin modulation of the eukaryotic cell cycle: are all cytolethal distending toxins created equally? causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23071106&form=6&db=m Potentiation of Sulfonylurea Action by an EPAC-selective cAMP Analog in INS-1 cells: comparison of Tolbutamide and Gliclazide and a potential role for EPAC activation of a 2-APB-sensitive Ca2+ influx. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23073075&form=6&db=m Fingolimod protects cultured cortical neurons against excitotoxic death. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23075100&form=6&db=m Pertussis toxin enhances colony organization of enzymatic-dissociated single human embryonic stem cells. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23076769&form=6&db=m External quality assessment of pertussis serology in Germany. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23084771&form=6&db=m Improved protocols for histamine sensitization testing of acellular pertussis vaccines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23086480&form=6&db=m Inflammatory effects of resistin on human smooth muscle cells: up-regulation of fractalkine and its receptor, CX3CR1 expression by TLR4 and Gi-protein pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23136934&form=6&db=m Heterotrimeric guanosine triphosphate-binding protein-coupled modulatory actions of motilin on K+ channels and postsynaptic ?-aminobutyric acid receptors in mouse medial vestibular nuclear neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23142606&form=6&db=m Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23149017&form=6&db=m Analyzing titers of antibodies against bacterial and viral antigens, and bacterial toxoids in the intravenous immunoglobulins utilized in Taiwan. causal interaction,diagnostic usage,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23152186&form=6&db=m Arsenic activates endothelin-1 Gi protein-coupled receptor signaling to inhibit stem cell differentiation in adipogenesis. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23159577&form=6&db=m Role of PKC?-p38 MAPK-Gi? axis in peroxynitrite-mediated inhibition of ?-adrenergic response in pulmonary artery smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23162530&form=6&db=m Plasma Norepinephrine in Hypertensive Rats Reflects ?(2)-Adrenoceptor Release Control Only When Re-Uptake is Inhibited. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23171706&form=6&db=m Inhibition of insulin secretion from rat pancreatic islets by dexmedetomidine and medetomidine, two sedatives frequently used in clinical settings. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23175253&form=6&db=m Pulsed-field gel electrophoresis analysis of Bordetella pertussis isolates circulating in Europe from 1998 to 2009. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23175530&form=6&db=m Conformational dynamics of Kir3.1/Kir3.2 channel activation via ?-opioid receptors. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23178946&form=6&db=m Specific roles of Gi protein family members revealed by dissecting somatostatin receptor 5 (SST5) coupling in human pituitary cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23179589&form=6&db=m Rapid elevation of calcium concentration in cultured dorsal spinal cord astrocytes by corticosterone. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23186989&form=6&db=m 1?,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-? phagocytosis and inflammation in Alzheimer's disease patients. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23197645&form=6&db=m Modulation of ?-opioid receptor signaling by RGS19 in SH-SY5Y cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23200035&form=6&db=m Oxidized lipids and lysophosphatidylcholine induce the chemotaxis and intracellular calcium influx in natural killer cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23207763&form=6&db=m The inhibitory G protein G(i) identified as pertussis toxin-catalyzed ADP-ribosylation. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23212907&form=6&db=m Regulation of the G-protein regulatory-G?i signaling complex by nonreceptor guanine nucleotide exchange factors. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23220156&form=6&db=m The functional activity of inhibitory G protein (G(i)) is not increased in failing heart ventricle. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23220722&form=6&db=m Juxtaglomerular cell CaSR stimulation decreases renin release via activation of the PLC/IP(3) pathway and the ryanodine receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23237870&form=6&db=m Inhibitory effect of ?-hydroxybutyric acid on L-type Ca(2+) current under ?-adrenergic stimulation in guinea pig cardiac ventricular myocytes. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23246833&form=6&db=m 27-hydroxycholesterol induces production of tumor necrosis factor-alpha from macrophages. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23250951&form=6&db=m The B subunit of an AB5 toxin produced by Salmonella enterica serovar Typhi up-regulates chemokines, cytokines, and adhesion molecules in human macrophage, colonic epithelial, and brain microvascular endothelial cell lines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23266471&form=6&db=m Pertussis toxin-sensitive heterotrimeric G?i/o proteins mediate WNT/?-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23282387&form=6&db=m GRO is Chemotactic for Human Intestinal Intraepithelial Lymphocytes. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23291938&form=6&db=m Confocal microscopy study of pertussis toxin and toxoids on CHO-cells. causal interaction,ongoing research,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23319636&form=6&db=m Analysis of naïve lung CD4 T cells provides evidence of functional lung to lymph node migration. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23328083&form=6&db=m Sphingosine kinase 1 expression is downregulated during differentiation of Friend cells due to decreased c-MYB. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23329401&form=6&db=m Reduced-antigen, combined diphtheria, tetanus, and acellular pertussis vaccine, adsorbed (boostrix(®)): a guide to its use as a single-dose booster immunization against pertussis. diagnostic usage,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23333242&form=6&db=m Ceramide 1-phosphate stimulates glucose uptake in macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23335001&form=6&db=m Dibutyryl Cyclic AMP Inhibits the Progression of Experimental Autoimmune Encephalomyelitis and Potentiates Recruitment of Endogenous Neural Stem Cells. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23336397&form=6&db=m Real-time detection of G protein activation using monomolecular G? FRET sensors. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23338277&form=6&db=m Prostaglandin E2 promotes liver cancer cell growth by the upregulation of FUSE-binding protein 1 expression. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23340219&form=6&db=m Mechanisms of vasorelaxation induced by oleoylethanolamide in the rat small mesenteric artery. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23341447&form=6&db=m ?-Arrestin Recruitment and G Protein Signaling by the Atypical Human Chemokine Decoy Receptor CCX-CKR. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23352492&form=6&db=m Genetic analysis of Bordetella pertussis in Ontario, Canada reveals one predominant clone. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23357406&form=6&db=m Mechanical regulation of native and the recombinant calcium channel. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23376159&form=6&db=m Purinergic P2Y1 receptor signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23388886&form=6&db=m Coupling factor 6 enhances the spontaneous microaggregation of platelets by decreasing cytosolic cAMP irrespective of antiplatelet therapy. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23388888&form=6&db=m Biphasic Erk1/2 activation sequentially involving Gs and Gi signaling is required in beta3-adrenergic receptor-induced primary smooth muscle cell proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23396229&form=6&db=m Signaling cross-talk between cannabinoid and muscarinic systems actives Rho-kinase and increases the contractile responses of the bovine ciliary muscle. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23396230&form=6&db=m A role for M2 and M3 muscarinic receptors in the contraction of rat and human small airways. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23404499&form=6&db=m Leucine Facilitates Insulin Signaling through a G?i Protein-dependent Signaling Pathway in Hepatocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23406868&form=6&db=m Pertussis resurgence: waning immunity and pathogen adaptation - two sides of the same coin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23407437&form=6&db=m Cloning and Expression of S1 Subunit of Pertussis Toxin in Escherichia coli. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23427281&form=6&db=m Estrogen Receptor Activation Protects Against TNF-?-Induced Endothelial Dysfunction. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23446189&form=6&db=m Evidence for m2 and m3 muscarinic receptor involvement in cholinergic excitatory junction potentials through synergistic activation of cation channels in the longitudinal muscle of mouse ileum. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23447594&form=6&db=m Cytotoxicity of intracellular a?42 amyloid oligomers involves Ca2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23447620&form=6&db=m Increased Agonist Affinity at the ?-Opioid Receptor Induced by Prolonged Agonist Exposure. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23449734&form=6&db=m Cross-talk between TGF-?1 and Muscarinic M2 Receptors Augments Airway Smooth Muscle Proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23452348&form=6&db=m Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23458724&form=6&db=m A proteoliposome formulation derived from Bordetella pertussis induces protection in two murine challenge models. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23468486&form=6&db=m Use of G-protein coupled and uncoupled CCR5 receptors by CCR5 inhibitor-resistant and -sensitive human immunodeficiency virus type 1 variants. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23470566&form=6&db=m Butyrate Attenuates Inflammation and Lipolysis Generated by the Interaction of Adipocytes and Macrophages. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23472053&form=6&db=m The cellular and molecular basis of bitter tastant-induced bronchodilation. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23508311&form=6&db=m Effect of GABA Receptor Agonists or Antagonists Injected Spinally on the Blood Glucose Level in Mice. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23516549&form=6&db=m A Real Time Chemotaxis Assay Unveils Unique Migratory Profiles amongst Different Primary Murine Macrophages. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23527161&form=6&db=m Insulin-like growth factor binding proteins increase intracellular calcium levels in two different cell lines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23536294&form=6&db=m Eosinophil adoptive transfer system to directly evaluate pulmonary eosinophil trafficking in vivo. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23544495&form=6&db=m [Influence of pertussis toxin on GPER-mediated activation of phosphatidylinositol 3-kinase/protein kinase B signaling induced by 17?-estradiol in endometrial carcinoma cells]. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23548612&form=6&db=m Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23556457&form=6&db=m Postsynaptic kainate receptor recycling and surface expression are regulated by metabotropic autoreceptor signalling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23564017&form=6&db=m ?2-adrenoceptor agonists can both stimulate and inhibit glucose uptake in mouse soleus muscle through ligand-directed signalling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23578140&form=6&db=m Phylogenetic approach for inferring the origin and functional evolution of bacterial ADP-ribosylation superfamily. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23615710&form=6&db=m Alpha-fetoprotein contributes to THP-1 cell invasion and chemotaxis via protein kinase and Gi-protein-dependent pathways. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23626476&form=6&db=m Signaling pathway of lysophosphatidic Acid-induced contraction in feline esophageal smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23631878&form=6&db=m Dopamine D2-like receptor signaling suppresses human osteoclastogenesis. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23650128&form=6&db=m Arsenic-stimulated lipolysis and adipose remodeling is mediated by G-protein-coupled receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23660634&form=6&db=m Pertussis toxin attenuates experimental autoimmune encephalomyelitis by upregulating neuronal vascular endothelial growth factor. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23664992&form=6&db=m Characterization of the carbohydrate binding and ADP-ribosyltransferase activities of chemically detoxified pertussis toxins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23698121&form=6&db=m Human kidney-2 cells harbor functional dopamine D1 receptors that require Gi? for Gq/11? signaling. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23698732&form=6&db=m Afamin stimulates osteoclastogenesis and bone resorption via Gi-coupled receptor and Ca2+/calmodulin-dependent protein kinase (CaMK) pathways. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23698749&form=6&db=m ?-Defensins activate human mast cells via Mas-related gene X2. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23756578&form=6&db=m Agonist-induced desensitization of human ?3-adrenoceptors expressed in human embryonic kidney cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23762421&form=6&db=m Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23770096&form=6&db=m Succinate receptor GPR91, a G?(i) coupled receptor that increases intracellular calcium concentrations through PLC?. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23770668&form=6&db=m Translocation of Activator of G-protein Signaling 3 to the Golgi Apparatus in Response to Receptor Activation and Its Effect on the trans-Golgi Network. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23776625&form=6&db=m Genome-wide gene expression analysis of Bordetella pertussis isolates associated with a resurgence in pertussis: elucidation of factors involved in the increased fitness of epidemic strains. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23789396&form=6&db=m [Regulation of adenylyl cyclase signaling system by insulin, biogenic amines, and glucagon at their separate and combined action in the muscle membranes of the mollusc Anodonta cygnea]. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23825105&form=6&db=m Distinctive G Protein-Dependent Signaling by Protease-Activated Receptor 2 (PAR2) in Smooth Muscle: Feedback Inhibition of RhoA by cAMP-Independent PKA. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23825195&form=6&db=m Differential T- and B-Cell Responses to Pertussis in Acellular Vaccine-Primed versus Whole-Cell Vaccine-Primed Children 2 Years after Preschool Acellular Booster Vaccination. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23835699&form=6&db=m Complex chemoattractive and chemorepellent Kit signals revealed by direct imaging of murine mast cells in microfluidic gradient chambers. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23838008&form=6&db=m Lysophosphatidylethanolamine utilizes LPA1 and CD97 in MDA-MB-231 breast cancer cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23839065&form=6&db=m Pleurocidin, a novel antimicrobial peptide, induces human mast cell activation through the FPRL1 receptor. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23892039&form=6&db=m Molecular and pharmacological characterization of zebrafish 'contractile' and 'inhibitory' prostanoid receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23906478&form=6&db=m ?-opioid receptor activation leads to neurite outgrowth and neuronal differentiation via a STAT5B-G?i/o pathway. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23911590&form=6&db=m Gz- and not Gi-proteins are coupled to pre-junctional ?-opioid receptors in bovine airways. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23913708&form=6&db=m Endogenous ACh tonically stimulates ANP secretion in rat atria. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23917535&form=6&db=m Contribution of membrane progesterone receptor ? to the induction of progesterone-mediated apoptosis associated with mitochondrial membrane disruption and caspase cascade activation in Jurkat cell lines. diagnostic usage,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23940034&form=6&db=m Identification of the C3a Receptor (C3AR1) as the Target of the VGF-derived Peptide TLQP-21 in Rodent Cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23949302&form=6&db=m Valproic Acid Attenuates Disease Symptoms and Increases Endogenous Myelin Repair by Recruiting Neural Stem Cells and Oligodendrocyte Progenitors in Experimental Autoimmune Encephalomyelitis. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23951229&form=6&db=m Lactate Modulates the Activity of Primary Cortical Neurons through a Receptor-Mediated Pathway. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23955529&form=6&db=m The Virulence Factors of Bordetella pertussis: Talented Modulators of Host Immune Response. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23959874&form=6&db=m Protein kinase C? as a therapeutic target stabilizing blood-brain barrier disruption in experimental autoimmune encephalomyelitis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23965380&form=6&db=m MENTHOL INHIBITS 5-HT3 RECEPTOR-MEDIATED CURRENTS. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23970813&form=6&db=m Persistent Inflammation in the CNS during Chronic EAE Despite Local Absence of IL-17 Production. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23971928&form=6&db=m [Seroepidemiology of pertussis in 10-15 years old healthy children in Isparta province, Turkey]. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23980112&form=6&db=m The RNA Chaperone Hfq is Required for Virulence of Bordetella pertussis. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23989451&form=6&db=m A Real-Time, Fluorescence-Based Assay for Measuring ?-Opioid Receptor Modulation of Adenylyl Cyclase Activity in Chinese Hamster Ovary Cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23994021&form=6&db=m Experience with monocomponent acellular pertussis combination vaccines for infants, children, adolescents and adults-A review of safety, immunogenicity, efficacy and effectiveness studies and 15 years of field experience. diagnostic usage,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23994446&form=6&db=m Agmatine induced NO dependent rat mesenteric artery relaxation and its impairment in salt-sensitive hypertension. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24018405&form=6&db=m Seroprevalence of pertussis in China: Need to improve vaccination strategies. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24019885&form=6&db=m Pertussis toxin B-pentamer mediates intercellular transfer of membrane proteins and lipids. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24043889&form=6&db=m Inflammatory Responses Induced by Lipopolysaccharide Are Amplified in Primary Human Monocytes but Suppressed in Macrophages by Complement Protein C5a. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24052258&form=6&db=m Neutrophil elastase and proteinase-3 trigger G-protein biased signaling through proteinase activated receptor-1 (PAR1). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24055089&form=6&db=m Identification of biomarkers to detect residual pertussis toxin using microarray analysis of dendritic cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24055502&form=6&db=m The actions of Pasteurella multocida toxin on neuronal cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24062570&form=6&db=m EP3 Receptor Isoforms are Differentially Expressed in Subpopulations of Primate Granulosa Cells and Couple to Unique G-Proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24069221&form=6&db=m Violet Light Down-Regulates the Expression of Specific Differentiation Markers through Rhodopsin in Normal Human Epidermal Keratinocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24083391&form=6&db=m Optical neuritis induced by different concentrations of myelin oligodendrocyte glycoprotein presents different profiles of the inflammatory process. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24103353&form=6&db=m Seroepidemiology of pertussis in a cross-sectional study of an adult general population in Denmark. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24106065&form=6&db=m Effect of Linker Length and Composition on Heterobivalent Ligand-Mediated Receptor Cross-Talk between the A1 Adenosine and ?2 Adrenergic Receptors. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24108779&form=6&db=m Immunogenicity and safety after booster vaccination of diphtheria, tetanus, and acellular pertussis in young adults: an open randomized controlled trial in Japan. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24116698&form=6&db=m [Diagnosis of whooping cough by serology and real-time PCR]. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24120989&form=6&db=m Effect of atrial natriuretic peptide on reactive oxygen species-induced by hydrogen peroxide in THP-1 monocytes: role in cell growth, migration and cytokine release. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24131698&form=6&db=m Evaluation of a multitarget real-time PCR assay for detection of Bordetella species during a pertussis outbreak in New Hampshire in 2011. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24140434&form=6&db=m Effects of cannabidiol on the function of ?7-nicotinic acetylcholine receptors. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24145616&form=6&db=m Lysophosphatidic acid activates ?-catenin/T cell factor signaling, which contributes to the suppression of apoptosis in H19-7 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24155894&form=6&db=m Natriuretic peptide receptor-C agonist attenuates the expression of cell cycle proteins and proliferation of vascular smooth muscle cells from spontaneously hypertensive rats: role of Gi proteins and MAPkinase/PI3kinase signaling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24176499&form=6&db=m Different T cell memory in preadolescents after whole-cell or acellular pertussis vaccination. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24184446&form=6&db=m Role of PKC-? in NADPH oxidase-PKC?-Gi? axis dependent inhibition of ?-adrenergic response by U46619 in pulmonary artery smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24184660&form=6&db=m ?-Tetrahydrocannabinol induces cytotoxicity in macrophage J774-1 cells: involvement of cannabinoid receptor 2 and p38 MAPK. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24188195&form=6&db=m Anti-myelin antibodies play an important role in the susceptibility to develop proteolipid protein-induced experimental autoimmune encephalomyelitis. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24218022&form=6&db=m Effects of cannabinoids on tension induced by acetylcholine and choline in slow skeletal muscle fibers of the frog. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24239776&form=6&db=m Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24243530&form=6&db=m Role of heterotrimeric G protein and calcium in cardiomyocyte hypertrophy induced by IGF-1. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24262995&form=6&db=m 2-methoxyestradiol binding of GPR30 down-regulates angiotensin AT(1) receptor. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24265450&form=6&db=m EP2 receptor activates dual G protein signaling pathways that mediate contrasting proinflammatory and relaxatory responses in term pregnant human myometrium. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24291093&form=6&db=m Presynaptic inhibition of gamma lobe neurons is required for olfactory learning in Drosophila. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24308586&form=6&db=m Clustered cases of Bordetella pertussis infection cause high levels of IgG antibodies against pertussis toxin in adolescents in Gaobeidian city, China. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24312373&form=6&db=m Normal autophagic activity in macrophages from mice lacking G?i3, AGS3, or RGS19. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24327954&form=6&db=m Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24337403&form=6&db=m Concomitant treatment with pertussis toxin plus temozolomide increases the survival of rats bearing intracerebral RG2 glioma. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24342806&form=6&db=m Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24353297&form=6&db=m The Drosophila neuropeptides PDF and sNPF have opposing electrophysiological and molecular effects on central neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24371118&form=6&db=m Histamine H2 receptor signaling x environment interactions determine susceptibility to experimental allergic encephalomyelitis. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24373940&form=6&db=m CXC chemokine receptor 4 signaling upon co-activation with stromal cell-derived factor-1? and ubiquitin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24375908&form=6&db=m Type 2 lysophosphatidic acid receptor in gastric surface mucous cells: Possible implication of prostaglandin E2 production. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24385109&form=6&db=m High-density lipoprotein induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through sphingosine kinase-2. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24385949&form=6&db=m Influence of the Adjuvants and Genetic Background on the Asthma Model Using Recombinant Der f 2 in Mice. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24387009&form=6&db=m Complement selectively elicits glutamate release from nerve endings in different regions of mammal central nervous system. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24388289&form=6&db=m An international collaborative study of the effect of active pertussis toxin on the modified Kendrick test for acellular pertussis vaccines. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24389135&form=6&db=m ?(2)-Adrenergic and M(2)-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24391789&form=6&db=m Loss of multi-epitope specificity in memory CD4(+) T cell responses to B. Pertussis with age. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24394373&form=6&db=m Report on the international workshop on alternatives to the murine histamine sensitization test (HIST) for acellular pertussis vaccines: State of the science and the path forward. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24397896&form=6&db=m Acellular pertussis vaccine based on outer membrane vesicles capable of conferring both long-lasting immunity and protection against different strain genotypes. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24407588&form=6&db=m Inhibitory signaling by CB1 receptors in smooth muscle mediated by GRK5/?-arrestin activation of ERK1/2 and Src kinase. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24416242&form=6&db=m Differentially expressed genes in Bordetella pertussis strains belonging to a lineage which recently spread globally. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24443946&form=6&db=m Role of Go/i subgroup of G proteins in olfactory signaling of Drosophila melanogaster. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24454823&form=6&db=m Age related differences in dynamics of specific memory B cell populations after clinical pertussis infection. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24469725&form=6&db=m Spheroid formation and invasion capacity are differentially influenced by co-cultures of fibroblast and macrophage cells in breast cancer. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24472666&form=6&db=m Effects of endogenous cannabinoid anandamide on excitation-contraction coupling in rat ventricular myocytes. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24478091&form=6&db=m G proteins G?i1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24486709&form=6&db=m Pertussis toxin modulates microglia and T cell profile to protect experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24496948&form=6&db=m Differential IL-10 production by DCs determines the distinct adjuvant effects of LPS and PTX in EAE induction. diagnostic usage,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24520353&form=6&db=m Endothelial differentiation gene-1, a new downstream gene is involved in RTEF-1 induced angiogenesis in endothelial cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24526726&form=6&db=m A new potassium ion current induced by stimulation of M2-cholinoreceptors in fish atrial myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24530743&form=6&db=m Substantial gaps in knowledge of Bordetella pertussis antibody and T cell epitopes relevant for natural immunity and vaccine efficacy. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24552423&form=6&db=m Bitter tastants induce relaxation of rat thoracic aorta precontracted with high K(+). ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24553455&form=6&db=m Toward a mechanism-based in vitro safety test for pertussis toxin. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24554758&form=6&db=m Antibody-mediated inhibition of Bordetella pertussis adenylate-cyclase hemolysin-induced macrophage cytotoxicity is influenced by variations in the bacterial population. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24557583&form=6&db=m Trans-cinnamic acid increases adiponectin and the phosphorylation of AMP-activated protein kinase through G-protein-coupled receptor signaling in 3T3-L1 adipocytes. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24569077&form=6&db=m Clusterin stimulates the chemotactic migration of macrophages through a pertussis toxin sensitive G-protein-coupled receptor and G??-dependent pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24586057&form=6&db=m Differential Effects of the G?5-RGS7 Complex on Muscarinic M3 Receptor-Induced Ca2+ Influx and Release. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24649065&form=6&db=m Direct regulation of vascular smooth muscle contraction by mastoparan-7. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24651459&form=6&db=m Dimers of G-protein coupled receptors as versatile storage and response units. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24662390&form=6&db=m Molecular cloning, expression, and signaling pathway of four melanin-concentrating hormone receptors from Xenopus tropicalis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24671202&form=6&db=m Distinct Pathways of ERK1/2 Activation by Hydroxy-Carboxylic Acid Receptor-1. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24674601&form=6&db=m Effects of endogenous cannabinoid anandamide on cardiac Na(+)/Ca(2+) exchanger. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24682435&form=6&db=m GABAB receptors are expressed in human aortic smooth muscle cells and regulate the intracellular Ca(2+) concentration. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24688019&form=6&db=m Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and ?-conotoxin Vc1.1 via GABAB receptor activation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24724723&form=6&db=m Melatonin Receptor MT1 Signals to Extracellular Signal-Regulated Kinase 1 and 2 via Gi and Gs Dually Coupled Pathways in HEK-293 Cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24730215&form=6&db=m [Serum immunoglobulin IgG subclass distribution of antibody responses to pertussis toxin and filamentous hemagglutinin of Bordetella pertussis in patients with whooping cough]. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24733850&form=6&db=m A biased non-G?i OXE-R antagonist demonstrates that G?i protein subunit is not directly involved in neutrophil, eosinophil, and monocyte activation by 5-oxo-ETE. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24734002&form=6&db=m Activation of ?-opioid receptors inhibits calcium-currents in the vestibular afferent neurons of the rat through a cAMP dependent mechanism. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24751713&form=6&db=m Emodin accentuates atrial natriuretic peptide secretion in cardiac atria. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24756212&form=6&db=m Decline of IgG pertussis toxin measured in umbilical cord blood, and neonatal and early infant serum. diagnostic usage,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24757216&form=6&db=m Global population structure and evolution of Bordetella pertussis and their relationship with vaccination. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24768867&form=6&db=m Modeling rates of infection with transient maternal antibodies and waning active immunity: application to Bordetella pertussis in Sweden. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24777913&form=6&db=m Basophil activation through ASGM1 stimulation triggers PAF release and anaphylaxis-like shock in mice. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24784882&form=6&db=m Investigation in a murine model of possible mechanisms of enhanced local reactions to post-primary diphtheria-tetanus toxoid boosters in recipients of acellular pertussis-diphtheria-tetanus vaccine. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24785532&form=6&db=m Relationship of immunogenicity to protective potency in acellular pertussis vaccines. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24793938&form=6&db=m B-cell responses after intranasal vaccination with the novel attenuated Bordetella pertussis vaccine strain BPZE1 in a randomized phase I clinical trial. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24797125&form=6&db=m Myelin oligodendrocyte glycoprotein (MOG35-55) induced experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24801497&form=6&db=m Human dendritic cell maturation and cytokine secretion upon stimulation with Bordetella pertussis filamentous haemagglutinin. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24804767&form=6&db=m Response of human thalamic neurons to high-frequency stimulation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24807055&form=6&db=m Pertussis toxin improves immune responses to a combined pneumococcal antigen and leads to enhanced protection against Streptococcus pneumoniae. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24819773&form=6&db=m Efficient neutrophil extracellular trap induction requires mobilization of both intracellular and extracellular calcium pools and is modulated by cyclosporine A. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24831005&form=6&db=m Tyrosine 308 is necessary for ligand-directed Gs protein-biased signaling of ?2-adrenoceptor. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24873871&form=6&db=m Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24875775&form=6&db=m The inflammasome pyrin contributes to pertussis toxin-induced IL-1? synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24879414&form=6&db=m Lysophosphatidic acid enhanced the angiogenic capability of human chondrocytes by regulating Gi/NF-kB-dependent angiogenic factor expression. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24911208&form=6&db=m Characterization of the contractile P2Y14 receptor in mouse coronary and cerebral arteries. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24922661&form=6&db=m The steroidal Na+/K+ ATPase inhibitor 3-[(R)-3-pyrrolidinyl]oxime derivative (3-R-POD) induces potent pro-apoptotic responses in colonic tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24923108&form=6&db=m Seroprevalence of antibodies to diphtheria, tetanus and pertussis among healthy adolescents and adults in Iran. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24925261&form=6&db=m ?-1 Receptor Inhibition of ASIC1a Channels is Dependent on a Pertussis Toxin-Sensitive G-Protein and an AKAP150/Calcineurin Complex. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24925807&form=6&db=m A rapid ELISA-based method for screening Bordetella pertussis strain production of antigens included in current acellular pertussis vaccines. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24926240&form=6&db=m Acute morphine alters GABAergic transmission in the central amygdala during naloxone-precipitated morphine withdrawal: role of cyclic AMP. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24937426&form=6&db=m Purinergic P2Y?? receptor modulates stress-induced hematopoietic stem/progenitor cell senescence. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24944813&form=6&db=m Effect of pertussis toxin on calcium influx in three contraction models. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24992986&form=6&db=m Pathogenesis and histopathology of pertussis: implications for immunization. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25017118&form=6&db=m Galanin receptor 2 utilizes distinct signaling pathways to suppress cell proliferation and induce apoptosis in HNSCC. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25023120&form=6&db=m Novel bacterial ADP-ribosylating toxins: structure and function. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25038866&form=6&db=m Estradiol increases cAMP in the oviductal secretory cells through a nongenomic mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25046840&form=6&db=m Neuropeptide FF receptors exhibit direct and anti-opioid effects on mice dorsal raphe nucleus neurons. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25049077&form=6&db=m Ghrelin suppresses Purkinje neuron P-type Ca(2+) channels via growth hormone secretagogue type 1a receptor, the ?? subunits of Go-protein, and protein kinase a pathway. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25069981&form=6&db=m Epithelial anion transporter pendrin contributes to inflammatory lung pathology in mouse models of Bordetella pertussis infection. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25073723&form=6&db=m Endothelial atypical cannabinoid receptor: do we have enough evidence? unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25093282&form=6&db=m Seroprevalence of IgG antibodies to pertussis toxin in children and adolescents in Estonia. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25096058&form=6&db=m Review of the laboratory approaches to the detection of antibody and cell-mediated immunity to pertussis disease and vaccine. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25108019&form=6&db=m Helminth-conditioned dendritic cells prime CD4+ T cells to IL-4 production in vivo. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25108158&form=6&db=m cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25138637&form=6&db=m G-protein-coupled receptor cell signaling pathways mediating embryonic chick retinal growth cone collapse induced by lysophosphatidic acid and sphingosine-1-phosphate. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25148774&form=6&db=m The induction of breast milk pertussis specific antibodies following gestational tetanus-diphtheria-acellular pertussis vaccination. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25161767&form=6&db=m The injury-induced myokine insulin-like 6 is protective in experimental autoimmune myositis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25165877&form=6&db=m Holo-APP and G-protein-mediated signaling are required for sAPP?-induced activation of the Akt survival pathway. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25171426&form=6&db=m Pertussis toxin administered spinally induces a hypoglycemic effect on normal and diabetic mice. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25173476&form=6&db=m The effect of timing of maternal tetanus, diphtheria, and acellular pertussis (Tdap) immunization during pregnancy on newborn pertussis antibody levels - a prospective study. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25179570&form=6&db=m Activation of spinal ?2 adrenergic receptors induces hyperglycemia in mouse though activating sympathetic outflow. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25183193&form=6&db=m Genetically detoxified pertussis toxin (PT-9K/129G): implications for immunization and vaccines. diagnostic usage,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25184503&form=6&db=m Seroprevalence study of B. pertussis infection in health care workers in Catalonia, Spain. diagnostic usage,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25188469&form=6&db=m High density lipoprotein stimulated migration of macrophages depends on the scavenger receptor class B, type I, PDZK1 and Akt1 and is blocked by sphingosine 1 phosphate receptor antagonists. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25193666&form=6&db=m Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25194146&form=6&db=m In vivo anti-LAP mAb enhances IL-17/IFN-? responses and abrogates anti-CD3-induced oral tolerance. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25198997&form=6&db=m Thioaryl naphthylmethanone oxime ether analogs as novel anticancer agents. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25203113&form=6&db=m Gi proteins regulate adenylyl cyclase activity independent of receptor activation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25205295&form=6&db=m Inhibition of a TREK-like K+ channel current by noradrenaline requires both ?1- and ?2-adrenoceptors in rat atrial myocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25205820&form=6&db=m Insulin secretion stimulated by L-arginine and its metabolite L-ornithine depends on G?(i2). diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25206651&form=6&db=m PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25216690&form=6&db=m Non-classical regulation of ?1- and ? 2-adrenoceptor-mediated inotropic responses in rat heart ventricle by the G protein Gi. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25218299&form=6&db=m Anti-pertussis antibody kinetics following DTaP-IPV booster vaccination in Norwegian children 7-8 years of age. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25218563&form=6&db=m Effect of pertussis and cholera toxins administered supraspinally on CA3 hippocampal neuronal cell death and the blood glucose level induced by kainic acid in mice. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25223977&form=6&db=m Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25240753&form=6&db=m Characterization of the key antigenic components of pertussis vaccine based on outer membrane vesicles. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25241062&form=6&db=m GABAB1 and GABAB2 receptor subunits co-expressed in cultured human RPE cells regulate intracellular Ca2+ via Gi/o-protein and phospholipase C pathways. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25243776&form=6&db=m Distinct signalling pathways of murine histamine H1- and H4-receptors expressed at comparable levels in HEK293 cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25244999&form=6&db=m Pertactin-negative Bordetella pertussis strains in Canada: characterization of a dozen isolates based on a survey of 224 samples collected in different parts of the country over the last 20 years. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25249503&form=6&db=m Physiological effects and therapeutic potential of proinsulin C-peptide. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25253303&form=6&db=m Platelet-derived sphingosine 1-phosphate induces migration of Jurkat T cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25268140&form=6&db=m Expression of DP2 (CRTh2), a prostaglandin D? receptor, in human mast cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25269092&form=6&db=m Low pertussis toxin antibody levels in two regional cohorts of Canadian pregnant women. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25283507&form=6&db=m Selective ?1B- and ?1D-adrenoceptor antagonists suppress noradrenaline-induced activation, proliferation and ECM secretion of rat hepatic stellate cells in vitro. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25286523&form=6&db=m [Immunogenicity and safety of vaccine preparations based on circulating Bordetella pertussis strains]. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25292213&form=6&db=m Peripheral pain is enhanced by insulin-like growth factor 1 through a G protein-mediated stimulation of T-type calcium channels. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25305315&form=6&db=m Alarmin function of cathelicidin antimicrobial peptide LL37 through IL-36? induction in human epidermal keratinocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25313102&form=6&db=m The Burden of Pertussis in Patients with and without Recurrent Ischaemic Vascular Events. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25346041&form=6&db=m The contribution of Gi/o protein to opioid antinociception in an oxaliplatin-induced neuropathy rat model. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25375133&form=6&db=m Niacin activates the PI3K/Akt cascade via PKC- and EGFR-transactivation-dependent pathways through hydroxyl-carboxylic acid receptor 2. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25403444&form=6&db=m CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25407356&form=6&db=m Inhibition of metabotropic glutamate receptor 5 induces cellular stress through pertussis toxin-sensitive G i -proteins in murine BV-2 microglia cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25411802&form=6&db=m Nicotinic acid increases adiponectin secretion from differentiated bovine preadipocytes through G-protein coupled receptor signaling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25424429&form=6&db=m Convergent regulation of neuronal differentiation and Erk and Akt kinases in human neural progenitor cells by lysophosphatidic acid, sphingosine 1-phosphate, and LIF: specific roles for the LPA1 receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25424662&form=6&db=m Pertussis serosurveillance study in izmir, Turkey. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25424817&form=6&db=m Relationship of immunogenicity to protective potency in acellular pertussis vaccines. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25424818&form=6&db=m Investigation in a murine model of possible mechanisms of enhanced local reactions to post-primary diphtheria-tetanus toxoid boosters in recipients of acellular pertussis-diphtheria-tetanus vaccine. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25432510&form=6&db=m Vaccines, emerging viruses, and how to avoid disaster. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25450673&form=6&db=m Phosphatidic acid inhibits ceramide 1-phosphate-stimulated macrophage migration. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25480129&form=6&db=m A two-phase within-host model for immune response and its application to serological profiles of pertussis. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25483286&form=6&db=m Somatostatin receptor subtype 4 modulates L-type calcium channels via G?? and PKC signaling in rat retinal ganglion cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25483549&form=6&db=m Seroprevalence study of B. pertussis infection in health care workers in Catalonia, Spain. diagnostic usage,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25483640&form=6&db=m Immunological persistence in 5 y olds previously vaccinated with hexavalent DTPa-HBV-IPV/Hib at 3, 5, and 11 months of age. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25501958&form=6&db=m Spp24 derivatives stimulate a gi -protein coupled receptor-erk1/2 signaling pathway and modulate gene expressions in w-20-17 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25505610&form=6&db=m Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25510388&form=6&db=m Interchangeability of meningococcal group C conjugate vaccines with different carrier proteins in the United Kingdom infant immunisation schedule. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25525298&form=6&db=m Osteopontin expression in the brain triggers localized inflammation and cell death when immune cells are activated by pertussis toxin. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25527446&form=6&db=m Analysis of Bordetella pertussis clinical isolates circulating in European countries during the period 1998-2012. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25545473&form=6&db=m Cannabinoid receptor 1 but not 2 mediates macrophage phagocytosis by G(?)i/o /RhoA/ROCK signaling pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25573035&form=6&db=m Combined tetanus-diphtheria and pertussis vaccine during pregnancy: transfer of maternal pertussis antibodies to the newborn. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25580562&form=6&db=m ?-Hydroxybutyric Acid Inhibits Growth Hormone-Releasing Hormone Synthesis and Secretion Through the GPR109A/Extracellular Signal-Regulated 1/2 Signalling Pathway in the Hypothalamus. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25592684&form=6&db=m Molecular mechanism for opioid dichotomy: bidirectional effect of ?-opioid receptors on P2X3 receptor currents in rat sensory neurones. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25601519&form=6&db=m Transforming growth factor ?2 (TGF-?2)-induced connective tissue growth factor (CTGF) expression requires sphingosine 1-phosphate receptor 5 (S1P5) in human mesangial cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25610957&form=6&db=m Characterization of co-purified acellular pertussis vaccines. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25617691&form=6&db=m Identification of amino acids that are selectively involved in Gi/o activation by rat melanin-concentrating hormone receptor 1. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25656479&form=6&db=m Orexin-A differentially modulates AMPA-preferring responses of ganglion cells and amacrine cells in rat retina. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25659150&form=6&db=m Tungstate-targeting of BK??1 channels tunes ERK phosphorylation and cell proliferation in human vascular smooth muscle. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25678708&form=6&db=m Urotensin-II receptor stimulation of cardiac L-type Ca2+ channels requires the ?? subunits of Gi/o-protein and phosphatidylinositol 3-kinase-dependent protein kinase C beta 1 isoform. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25689536&form=6&db=m Investigating pertussis toxin and its impact on vaccination. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25690038&form=6&db=m ?-Hydroxybutyric Sodium Salt Inhibition of Growth Hormone and Prolactin Secretion via the cAMP/PKA/CREB and AMPK Signaling Pathways in Dairy Cow Anterior Pituitary Cells. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25694144&form=6&db=m Label-free detection and identification of protein ligands captured by receptors in a polymerized planar lipid bilayer using MALDI-TOF MS. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25707622&form=6&db=m Melatonin-mediated inhibition of Purkinje neuron P-type Ca(2+) channels in vitro induces neuronal hyperexcitability through the phosphatidylinositol 3-kinase-dependent protein kinase C delta pathway. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25711465&form=6&db=m Melatonin-mediated Bim up-regulation and cyclooxygenase-2 (COX-2) down-regulation enhances tunicamycin-induced apoptosis in MDA-MB-231 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25741585&form=6&db=m Nuclear membrane R-type calcium channels mediate cytosolic ET-1-induced increase of nuclear calcium in human vascular smooth muscle cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25742911&form=6&db=m Testing implications of varying targets for Bordetella pertussis: comparison of the FilmArray Respiratory Panel and the Focus B. pertussis PCR assay. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25773760&form=6&db=m Effects of blockade of endogenous Gi signaling in Tie2-expressing cells on bone formation in a mouse model of heterotopic ossification. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25777964&form=6&db=m Synthetic Lethal Screens Identify Vulnerabilities in GPCR Signaling and Cytoskeletal Organization in E-Cadherin-Deficient Cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25780928&form=6&db=m Analysis of neurogenesis during experimental autoimmune encephalomyelitis reveals pitfalls of bioluminescence imaging. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25782002&form=6&db=m Apelin-13 enhances arcuate POMC neuron activity via inhibiting M-current. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25787136&form=6&db=m Identification of pertussis-specific effector memory T cells in preschool children. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25804072&form=6&db=m [Evaluation of Bordetella pertussis strains toxicity in vitro using CHO cell lines]. diagnostic usage,ongoing research,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25815340&form=6&db=m The differential effects of a selective kappa-opioid receptor agonist, U50488, in guinea pig heart tissues. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25817573&form=6&db=m Neuropeptide Y receptor mediates activation of ERK1/2 via transactivation of the IGF receptor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25823220&form=6&db=m Regulation of cardiac ?3-adrenergic receptors in hyperglycemia. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25835294&form=6&db=m Ratiometric analysis of fura red by flow cytometry: a technique for monitoring intracellular calcium flux in primary cell subsets. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25848782&form=6&db=m Usefulness of laboratory methods in diagnosis of pertussis in adult with paroxysmal cough. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25859982&form=6&db=m Hesperidin, a Citrus Flavonoid, Has the Ameliorative Effects Against Experimental Autoimmune Encephalomyelitis (EAE) in a C57BL/J6 Mouse Model. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25861926&form=6&db=m Molecular epidemiology of Bordetella pertussis in the Philippines in 2012-2014. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25863040&form=6&db=m Mycophenolate mofetil and cyclophosphamide treatments suppress inflammation intensity in an experimental model of autoimmune uveitis. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25869129&form=6&db=m Tricyclic Antidepressant Amitriptyline-induced Glial Cell Line-derived Neurotrophic Factor Production Involves Pertussis Toxin-sensitive G?i/o Activation in Astroglial Cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25874559&form=6&db=m Pertussis in infants less than 6 months of age and household contacts, Italy, April 2014. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25888927&form=6&db=m Antidepressants activate the lysophosphatidic acid receptor LPA(1) to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25899939&form=6&db=m Muscarinic modulation of TREK currents in mouse sympathetic superior cervical ganglion neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25904189&form=6&db=m Experimental and clinical aspects of melatonin and clock genes in diabetes. causal interaction,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25911435&form=6&db=m Cell-based assay of nongenomic actions of progestins revealed inhibitory G protein coupling to membrane progestin receptor ? (mPR?). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25913647&form=6&db=m Bordetella pertussis infection in paediatric healthcare workers. diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25917236&form=6&db=m Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25965341&form=6&db=m Treatment with Vitamin D/MOG Association Suppresses Experimental Autoimmune Encephalomyelitis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25972449&form=6&db=m Direct Coupling of a Seven-Transmembrane-Span Receptor to a G?i G-Protein Regulatory Motif Complex. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25997563&form=6&db=m Nesfatin-1 Suppresses Cardiac L-type Ca²? Channels Through Melanocortin Type 4 Receptor and the Novel Protein Kinase C Theta Isoform Pathway. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26007235&form=6&db=m G?s proteins activate p72(Syk) and p60-c-Src tyrosine kinases to mediate sickle red blood cell adhesion to endothelium via LW-?v?3 and CD44-CD44 interactions. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26009767&form=6&db=m Muscarinic inhibition of nicotinic transmission in rat sympathetic neurons and adrenal chromaffin cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26014907&form=6&db=m A versatile, non genetically modified organism (GMO)-based strategy for controlling low-producer mutants in Bordetella pertussis cultures using antigenic modulation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26022362&form=6&db=m The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26027517&form=6&db=m The autotaxin-LPA2 GPCR axis is modulated by ?-irradiation and facilitates DNA damage repair. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26033291&form=6&db=m Primary Macrophage Chemotaxis Induced by Cannabinoid Receptor 2 Agonists Occurs Independently of the CB2 Receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26045691&form=6&db=m Inhibition of L-type Ca(2+) current by ginsenoside Rd in rat ventricular myocytes. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26067183&form=6&db=m Needle-free and adjuvant-free epicutaneous boosting of pertussis immunity: Preclinical proof of concept. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26086964&form=6&db=m Calcium flux-independent NMDA receptor activity is required for A? oligomer-induced synaptic loss. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26097205&form=6&db=m Stimulatory effects of histamine on migration of nasal fibroblasts. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26101138&form=6&db=m Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26134278&form=6&db=m Detection of antibodies against fimbria type 3 (Fim3) is useful diagnostic assay for pertussis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26149936&form=6&db=m The potential of adjuvants to improve immune responses against TdaP vaccines: A preclinical evaluation of MF59 and monophosphoryl lipid A. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26160743&form=6&db=m The Decline of Pertussis-Specific Antibodies After Tetanus, Diphtheria, and Acellular Pertussis Immunization in Late Pregnancy. causal interaction,diagnostic usage,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26168033&form=6&db=m Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26174421&form=6&db=m KATP channels in the nodose ganglia mediate the orexigenic actions of ghrelin. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26177302&form=6&db=m Seroepidemiology of diphtheria and pertussis in Beijing, China: A cross-sectional study. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26182210&form=6&db=m Genetic Variation of Bordetella pertussis in Austria. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26194831&form=6&db=m Characterization of two Achromobacter xylosoxidans isolates from patients with pertussis-like symptoms. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26199630&form=6&db=m Evaluation of Antidiabetic Effects of the Traditional Medicinal Plant Gynostemma pentaphyllum and the Possible Mechanisms of Insulin Release. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26208712&form=6&db=m L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26211974&form=6&db=m Cross-talk between metabotropic glutamate receptor 7 and beta adrenergic receptor signaling at cerebrocortical nerve terminals. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26212359&form=6&db=m Proinflammatory receptor switch from G?s to G?i signaling by ?-arrestin-mediated PDE4 recruitment in mixed RA synovial cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26239659&form=6&db=m GABAB receptors inhibit low-voltage activated and high-voltage activated Ca(2+) channels in sensory neurons via distinct mechanisms. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26276085&form=6&db=m Cardiac effects of long-term active immunization with the second extracellular loop of human ?1- and/or ?3-adrenoceptors in Lewis rats. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26277068&form=6&db=m Estimated and reported incidence of pertussis in Estonian adults: A seroepidemiological study. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26296891&form=6&db=m Rapid fine conformational epitope mapping using comprehensive mutagenesis and deep sequencing. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26303466&form=6&db=m Selective mu and kappa Opioid Agonists Inhibit Voltage-Gated Ca2+ Entry in Isolated Neonatal Rat Carotid Body Type I Cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26308112&form=6&db=m Concomitant use of VAQTA® with PedvaxHIB® and Infanrix® in 12 to 17 month old children. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26308522&form=6&db=m Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26324705&form=6&db=m Pertussis Toxin Exploits Specific Host Cell Signaling Pathways for Promoting Invasion and Translocation of Escherichia coli K1 RS218 in Human Brain-derived Microvascular Endothelial Cells. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26346517&form=6&db=m Immobilization Stress With ?2-Adrenergic Stimulation Induces Regional and Transient Reduction of Cardiac Contraction Through Gi Coupling in Rats. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26365274&form=6&db=m Pertussis toxin reduces calcium influx to protect ischemic stroke in a middle cerebral artery occlusion model. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26373672&form=6&db=m An essential role for G?(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26375454&form=6&db=m Single Amino Acid Polymorphisms of Pertussis Toxin Subunit S2 (PtxB) Affect Protein Function. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26375619&form=6&db=m Helicobacter pylori neutrophil-activating protein induces release of histamine and interleukin-6 through G protein-mediated MAPKs and PI3K/Akt pathways in HMC-1 cells. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26377185&form=6&db=m Dopamine agonist inhibits vascular endothelial growth factor protein production and secretion in granulosa cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26377915&form=6&db=m Interleukin-36? is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26389958&form=6&db=m New Data on Vaccine Antigen Deficient Bordetella pertussis Isolates. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26394801&form=6&db=m Contribution of pertussis toxin to the pathogenesis of pertussis disease. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26398720&form=6&db=m Identification of N-arachidonoyl dopamine as a highly biased ligand at cannabinoid CB1 receptors. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26400888&form=6&db=m [Bordetella pertussis lipooligosaccharide-derived neoglycoconjugates - new components of pertussis vaccine]. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26401953&form=6&db=m Rescheduling Behavioral Subunits of a Fixed Action Pattern by Genetic Manipulation of Peptidergic Signaling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26409140&form=6&db=m Genetic diversity and population dynamics of Bordetella pertussis in China between 1950-2007. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26412843&form=6&db=m Prevalence, diagnosis, and disease course of pertussis in adults with acute cough: a prospective, observational study in primary care. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26432818&form=6&db=m Review of the neutrophil response to Bordetella pertussis infection. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26441085&form=6&db=m AKT-independent Reelin signaling requires interactions of heterotrimeric Go and Src. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26448300&form=6&db=m [Antigenic variability of Bordetella pertussis strains isolated in 1967-2010 in the Czech Republic--possible explanation for the rise in cases of pertussis?]. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26469136&form=6&db=m Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26472731&form=6&db=m Somatostatin activates Ras and ERK1/2 via a G protein ??-subunit-initiated pathway in thyroid cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26490245&form=6&db=m Voltage-Gated R-Type Calcium Channel Inhibition via Human ?-, ?-, and ?-opioid Receptors Is Voltage-Independently Mediated by G?? Protein Subunits. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26497105&form=6&db=m Ligand-biased activation of extracellular signal-regulated kinase 1/2 leads to differences in opioid induced antinociception and tolerance. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26518989&form=6&db=m Disulfanyl peptide decreases melanin synthesis via receptor-mediated ERK activation and the subsequent downregulation of MITF and tyrosinase. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26522434&form=6&db=m Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26523641&form=6&db=m Detection of Bordetella pertussis using a PCR test in infants younger than one year old hospitalized with whooping cough in five Peruvian hospitals. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26524499&form=6&db=m Enhanced expression of Gi? proteins contributes to the hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats via MAP kinase- and PI3 kinase-independent pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26529073&form=6&db=m Pertussis vaccination during pregnancy in Vietnam: Results of a randomized controlled trial Pertussis vaccination during pregnancy. diagnostic usage,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26546817&form=6&db=m Apelin-13 upregulates Egr-1 expression in rat vascular smooth muscle cells through the PI3K/Akt and PKC signaling pathways. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26550168&form=6&db=m Protective effects of remote ischemic preconditioning in isolated rat hearts. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26552301&form=6&db=m [ROLE PHOSPHOINOSITID SIGNALING PATHWAY IN OPIOIDS CONTROL OF P2X3 RECEPTORS IN THE PRIMARY SENSORY NEURONS]. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26557022&form=6&db=m Multiple Signaling Pathways Contribute to the Thrombin-induced Secretory Phenotype in Vascular Smooth Muscle Cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26558361&form=6&db=m The critical points in induction of experimental autoimmune uveitis. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26560437&form=6&db=m Guanosine triphosphate can directly regulate cortisol production by activating Ca(2+)-messenger systems in bovine adrenal fasciculata cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26564962&form=6&db=m Myelin oligodendrocyte glycoprotein (MOG35-55)-induced experimental autoimmune encephalomyelitis is ameliorated in interleukin-32 alpha transgenic mice. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26565897&form=6&db=m High rate of vaccine failure after administration of acellular pertussis vaccine pre- and post-liver transplantation in children at a children's hospital in Japan. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26592142&form=6&db=m Pertussis vaccination during pregnancy in Belgium: Results of a prospective controlled cohort study. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26593425&form=6&db=m The effects of female sexual hormones on the expression and function of ?1A- and ?1D-adrenoceptor subtypes in the late-pregnant rat myometrium. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26607401&form=6&db=m Adenylate cyclase toxin-mediated delivery of the S1 subunit of pertussis toxin into mammalian cells. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26616879&form=6&db=m Pertussis toxin promotes relapsing-remitting experimental autoimmune encephalomyelitis in Lewis rats. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26623626&form=6&db=m Bordetella pertussis diagnosis in children under five years of age in the Regional Hospital of Cajamarca, Northern Peru. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26626910&form=6&db=m High prevalence of Bordetella pertussis in children under 5 years old hospitalized with acute respiratory infections in Lima, Peru. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26631634&form=6&db=m A cocktail of humanized anti-pertussis toxin antibodies limits disease in murine and baboon models of whooping cough. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26643932&form=6&db=m Pertussis specific cell-mediated immune responses ten years after acellular pertussis booster vaccination in young adults. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26658454&form=6&db=m The experimental power of FR900359 to study Gq-regulated biological processes. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26663017&form=6&db=m An antimicrobial peptide with angiogenic properties, AG-30/5C, activates human mast cells through the MAPK and NF-?B pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26675318&form=6&db=m The relationship between Bordetella pertussis genotype and clinical severity in Australian children with pertussis. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26703472&form=6&db=m Serum Amyloid A3 Secreted by Preosteoclasts Inhibits Parathyroid Hormone-stimulated cAMP Signaling in Murine Osteoblasts. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26707801&form=6&db=m Ceramide 1-phosphate regulates cell migration and invasion of human pancreatic cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26724970&form=6&db=m The potential role of subclinical Bordetella Pertussis colonization in the etiology of multiple sclerosis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26740622&form=6&db=m Rapid Remodeling of Invadosomes by Gi-coupled Receptors: DISSECTING THE ROLE OF Rho GTPases. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26755534&form=6&db=m The chromosomal nature of LT-II enterotoxins solved: a lambdoid prophage encodes both LT-II and one of two novel pertussis-toxin-like toxin family members in type II enterotoxigenic Escherichia coli. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26763395&form=6&db=m Cigarette smoke extract-induced interleukin-6 expression is regulated by phospholipase D1 in human bronchial epithelial cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26797213&form=6&db=m Maternal Immunization Earlier in Pregnancy Maximizes Antibody Transfer and Expected Infant Seropositivity Against Pertussis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26799488&form=6&db=m A New Generation of FRET Sensors for Robust Measurement of G?i1, G?i2 and G?i3 Activation Kinetics in Single Cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26807027&form=6&db=m Effect of D-glucose feeding on mortality induced by sepsis. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26809648&form=6&db=m Adult pertussis is unrecognized public health problem in Thailand. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26812174&form=6&db=m Bordetella pertussis Strain Lacking Pertactin and Pertussis Toxin. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26822306&form=6&db=m Immunomodulation By Subchronic Low Dose 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26823763&form=6&db=m Development of an improved animal model of experimental autoimmune myositis. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26826518&form=6&db=m Genomic dissection of Australian Bordetella pertussis isolates from the 2008-2012 epidemic. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26826667&form=6&db=m Agonist-Induced Activation of Histamine H3 Receptor Signals to Extracellular Signal-Regulated Kinases 1 and 2 through PKC-, PLD- and EGFR-dependent Mechanisms. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26834156&form=6&db=m IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26835606&form=6&db=m Rapid high mass resolution mass spectrometry using matrix-assisted ionization. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26837004&form=6&db=m Seroprevalence of Antibodies to Pertussis Toxin among Different Age Groups in Thailand after 37 Years of Universal Whole-Cell Pertussis Vaccination. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26843606&form=6&db=m G?14 subunit-mediated inhibition of voltage-gated Ca2+ and K+ channels via neurokinin-1 receptors in rat celiac-superior mesenteric ganglion neurons. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26854275&form=6&db=m Neural FFA3 activation inversely regulates anion secretion evoked by nicotinic ACh receptor activation in rat proximal colon. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26883463&form=6&db=m Chemokine release from human rhinovirus-infected airway epithelial cells promotes fibroblast migration. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26904725&form=6&db=m Detection of Bordetella pertussis from Clinical Samples by Culture and End-Point PCR in Malaysian Patients. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26906206&form=6&db=m Bordetella pertussis: new concepts in pathogenesis and treatment. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26911613&form=6&db=m Early IFN-? production together with decreased expression of TLR3 and TLR9 characterizes EAE development conditional on the presence of myelin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26922984&form=6&db=m Persistence of T-cell immune response induced by two acellular pertussis vaccines in children five years after primary vaccination. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26928315&form=6&db=m A leading role for NADPH oxidase in an in-vitro study of experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26950201&form=6&db=m Multiple Transduction Pathways Mediate Thyrotropin Receptor Signaling in Preosteoblast-Like Cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26954502&form=6&db=m On the selectivity of the G?q inhibitor UBO-QIC: A comparison with the G?i inhibitor pertussis toxin. ongoing research,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26968625&form=6&db=m The optimal gestation for pertussis vaccination during pregnancy: a prospective cohort study. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26969240&form=6&db=m Signalling mechanism for somatostatin receptor 5-mediated suppression of AMPA responses in rat retinal ganglion cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26973066&form=6&db=m Effect of different detoxification procedures on the residual pertussis toxin activities in vaccines. causal interaction,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26975784&form=6&db=m Nesfatin-1 increases intracellular calcium concentration by protein kinase C activation in cultured rat dorsal root ganglion neurons. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26985768&form=6&db=m CCR5 knockout suppresses experimental autoimmune encephalomyelitis in C57BL/6 mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26988163&form=6&db=m CL316243 induces phosphatidylinositol 3,4,5-triphosphate production in rat adipocytes in an adenosine deaminase-, pertussis toxin-, or wortmannin-sensitive manner. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26996108&form=6&db=m Increase in mRNA Level of Orexin1 and 2 Receptors Following Induction of Experimental Autoimmune Encephalomyelitis in Mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27004692&form=6&db=m Oestrogen exerts anti-inflammation via p38 MAPK/NF-?B cascade in adipocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27025291&form=6&db=m Go is required for the release of IL-8 and TNF-?, but not degranulation in human mast cells. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27030626&form=6&db=m Rat white adipocytes activate p85/p110 PI3K and induce PM GLUT4 in response to adrenoceptor agonists or aluminum fluoride. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27038234&form=6&db=m Intrathecal administration of low-dose nociceptin/orphanin FQ induces allodynia via c-Jun N-terminal kinase and monocyte chemoattractant protein-1. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27038931&form=6&db=m Stromal Cell-Derived Factor 1 Increases Tetrodotoxin-Resistant Sodium Currents Nav1.8 and Nav1.9 in Rat Dorsal Root Ganglion Neurons via Different Mechanisms. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27041283&form=6&db=m [The Clinical Signs of Experimental Autoimmune Uveitis]. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27048097&form=6&db=m Bacterial type AB? enterotoxins--structure, function and mechanism of action. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27049571&form=6&db=m Systemic ocular antigen immunization leads only to a minor secondary immune response. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27065246&form=6&db=m Ionomycin induces prostaglandin E2 formation in murine osteoblastic MC3T3-E1 cells via mechanisms independent of its ionophoric nature. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27068148&form=6&db=m WAY208466 inhibits glutamate release at hippocampal nerve terminals. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27071343&form=6&db=m The impact of RGS and other G-protein regulatory proteins on G?i-mediated signaling in immunity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27075428&form=6&db=m Gi-protein-coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27075481&form=6&db=m Evidence of increased circulation of Bordetella pertussis in the Italian adult population from seroprevalence data (2012-2013). diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27084102&form=6&db=m Cytokine-like 1 Chemoattracts Monocytes/Macrophages via CCR2. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27089415&form=6&db=m CB1 cannabinoid receptor-mediated increases in cyclic AMP accumulation are correlated with reduced Gi/o function. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27113277&form=6&db=m Corrigendum to "Accelerated maternal responding following intra-VTA pertussis toxin treatment" [Behav. Brain Res. 223 (October (2)) (2011) 322-328; Epub 2011 May 6]. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27131737&form=6&db=m Moesin regulates neutrophil rolling velocity in vivo. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27142328&form=6&db=m Pertussis vaccination during pregnancy in Belgium: Follow-up of infants until 1 month after the fourth infant pertussis vaccination at 15 months of age. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27156838&form=6&db=m Serotonin type-1D receptor stimulation of A-type K(+) channel decreases membrane excitability through the protein kinase A- and B-Raf-dependent p38 MAPK pathways in mouse trigeminal ganglion neurons. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27164414&form=6&db=m Implication of matrix metalloproteinases 2 and 9 in ceramide 1-phosphate-stimulated macrophage migration. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27170493&form=6&db=m Cholesterol regulates contractility and inotropic response to ?2-adrenoceptor agonist in the mouse atria: Involvement of Gi-protein-Akt-NO-pathway. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27171114&form=6&db=m A Belgian Serosurveillance/Seroprevalence Study of Diphtheria, Tetanus and Pertussis Using a Luminex xMAP Technology-Based Pentaplex. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27189410&form=6&db=m Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1? production by myeloid cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27237973&form=6&db=m G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27243554&form=6&db=m Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27255149&form=6&db=m Pertussis Antibody Concentrations in Infants Born Prematurely to Mothers Vaccinated in Pregnancy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27269634&form=6&db=m Simulated Microgravity Disrupts Cytoskeleton Organization and Increases Apoptosis of Rat Neural Crest Stem Cells Via Upregulating CXCR4 Expression and RhoA-ROCK1-p38 MAPK-p53 Signaling. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27282930&form=6&db=m Polymorphism of IL-10 gene promoter region: association with T cell proliferative responses after acellular pertussis vaccination in adults. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27302339&form=6&db=m Purification design and practice for pertactin, the third component of acellular pertussis vaccine, from Bordetella pertussis. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27343802&form=6&db=m Peripheral and central neuronal ATF3 precedes CD4+ T-cell infiltration in EAE. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27369899&form=6&db=m Intracellular disassembly and activity of pertussis toxin require interaction with ATP. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27465637&form=6&db=m Bordetella pertussis modulates human macrophage defense gene expression. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27467322&form=6&db=m [Novel approaches to control the rise in pertussis cases]. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27480930&form=6&db=m A label-free impedance-based whole cell assay revealed a new G protein-coupled receptor ligand for mouse microglial cell migration. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27506252&form=6&db=m Transferability study of CHO cell clustering assays for monitoring of pertussis toxin activity in acellular pertussis vaccines. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27506997&form=6&db=m Cannabinoid-induced depression of synaptic transmission is switched to stimulation when dopaminergic tone is increased in the globus pallidus of the rodent. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27510906&form=6&db=m Angiotensin II counteracts the effects of cAMP/PKA on NHE3 activity and phosphorylation in proximal tubule cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27570060&form=6&db=m Niacin receptor GPR109A inhibits insulin secretion and is down-regulated in type 2 diabetic islet beta-cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27581436&form=6&db=m Synergistic neutralization of pertussis toxin by a bispecific antibody in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27600870&form=6&db=m Biased ?-opioid receptor agonists diversely regulate lateral mobility and functional coupling of the receptor to its cognate G proteins. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27605627&form=6&db=m LPA1 mediates antidepressant-induced ERK1/2 signalling and protection from oxidative stress in glial cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27609461&form=6&db=m Pertussis Leukocytosis: Mechanisms, Clinical Relevance and Treatment. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27610007&form=6&db=m Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27610033&form=6&db=m Effect of pertussis toxin pretreated centrally on blood glucose level induced by stress. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27613866&form=6&db=m Positive Allosteric Modulation of the Calcium-sensing Receptor by Physiological Concentrations of Glucose. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27614887&form=6&db=m Parents as source of pertussis transmission in hospitalized young infants. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27647866&form=6&db=m Thermal Unfolding of the Pertussis Toxin S1 Subunit Facilitates Toxin Translocation to the Cytosol by the Mechanism of Endoplasmic Reticulum-Associated Degradation. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27666464&form=6&db=m Prior exposure to Bordetella species as an exclusion criterion in the baboon model of pertussis. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27686182&form=6&db=m Randomized clinical trial of the safety and immunogenicity of the Tdap vaccine in pregnant Mexican women. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27686283&form=6&db=m Safety and immunogenicity of a combined Tetanus, Diphtheria, recombinant acellular Pertussis vaccine (TdaP) in healthy Thai adults. ongoing research,therapeutic application,unassigned 4,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27689011&form=6&db=m The regulator of G-protein signaling RGS16 promotes insulin secretion and ?-cell proliferation in rodent and human islets. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27748951&form=6&db=m 1-Fluoro-2,4-dinitrobenzene and its derivatives act as secretagogues on rodent mast cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27751876&form=6&db=m Label-free versus conventional cellular assays: Functional investigations on the human histamine H1 receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27753797&form=6&db=m A Randomized, Controlled Study of DTaP-IPV-HB-PRP-T, a Fully Liquid Hexavalent Vaccine, Administered in a 3-, 5- and 11- to 12-month Schedule. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27754355&form=6&db=m Pertussis Toxin Exploits Host Cell Signaling Pathways Induced by Meningitis-Causing E. coli K1-RS218 and Enhances Adherence of Monocytic THP-1 Cells to Human Cerebral Endothelial Cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27815382&form=6&db=m Reduction of Pertussis Inflammatory Pathology by Therapeutic Treatment With Sphingosine-1-Phosphate Receptor Ligands by a Pertussis Toxin-Insensitive Mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27827809&form=6&db=m IL-1 signaling is critical for expansion but not generation of autoreactive GM-CSF+ Th17 cells. causal interaction,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27833142&form=6&db=m Murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27838673&form=6&db=m The Effect of Maternal Pertussis Immunization on Infant Vaccine Responses to a Booster Pertussis-Containing Vaccine in Vietnam. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27849178&form=6&db=m Modulation of Pertussis and Adenylate Cyclase Toxins by Sigma Factor RpoE in Bordetella pertussis. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27853066&form=6&db=m Concentrations of Immunoglobulin G Antibodies Against Pertussis Toxin Does Not Decrease Over a Long Period of Time in Japan. diagnostic usage,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27870812&form=6&db=m Does Breastfeeding Protect Young Infants From Pertussis? Case-control Study and Immunologic Evaluation. diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27890480&form=6&db=m Chemerin-induced arterial contraction is Gi- and calcium-dependent. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27905894&form=6&db=m Seroprevalence of Bordetella pertussis specific Immunoglobulin G antibody levels among asymptomatic individuals aged 4 to 24 years: a descriptive cross sectional study from Sri Lanka. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27912212&form=6&db=m Knockdown of Inhibitory Guanine Nucleotide Binding Protein Gi?-2 by Antisense Oligodeoxynucleotides Attenuates the Development of Hypertension and Tachycardia in Spontaneously Hypertensive Rats. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27974227&form=6&db=m Evaluation of a commercial loop-mediated isothermal amplification assay for diagnosis of Bordetella pertussis infection. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27977780&form=6&db=m Pertussis Toxin Is a Robust and Selective Inhibitor of High Grade Glioma Cell Migration and Invasion. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27986909&form=6&db=m SOS1, ARHGEF1, and DOCK2 rho-GEFs Mediate JAK-Dependent LFA-1 Activation by Chemokines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28008531&form=6&db=m G-Protein coupled progesterone receptors in the plasma membrane of fungus Rhizopus nigricans. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28011915&form=6&db=m Genome-Wide Association Mapping of the Antibody Response to Diphtheria, Tetanus and Acellular Pertussis Vaccine in Mice. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28017639&form=6&db=m Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28039663&form=6&db=m Whooping Cough in Adults: A Series of Severe Cases. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28040688&form=6&db=m Prevalence of Pertussis Antibodies in Maternal Blood, Cord Serum, and Infants From Mothers With and Those Without Tdap Booster Vaccination During Pregnancy in Argentina. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28069828&form=6&db=m LPA1 receptor-mediated thromboxane A2 release is responsible for lysophosphatidic acid-induced vascular smooth muscle contraction. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28082199&form=6&db=m Ric-8A-mediated stabilization of the trimeric G protein subunit G?i is inhibited by pertussis toxin-catalyzed ADP-ribosylation. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28082327&form=6&db=m A Functional and Neuropathological Testing Paradigm Reveals New Disability-Based Parameters and Histological Features for P0180-190-Induced Experimental Autoimmune Neuritis in C57BL/6 Mice. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28089363&form=6&db=m Pertussis toxin targets the innate immunity through DAP12, FcR?, and MyD88 adaptor proteins. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28095239&form=6&db=m Evidence for a cyclic AMP-dependent pathway in angiotensin AT1-receptor activation of human omental arteries. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28100502&form=6&db=m RACK1 regulates angiotensin II-induced contractions of SHR preglomerular vascular smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28119127&form=6&db=m Antagonizing the different stages of kappa opioid receptor activation selectively and independently attenuates acquisition and consolidation of associative memories. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28122730&form=6&db=m Distinct Physiological Effects of ?1- and ?2-Adrenoceptors in Mouse Ventricular Myocytes: Insights from a Compartmentalized Mathematical Model. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28125291&form=6&db=m Epstein-Barr Virus Induced Gene 2 (EBI2) Mediates Allergen-induced, Leukocyte Migration into Airways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28129894&form=6&db=m Reporter cell lines for detection of pertussis toxin in acellular pertussis vaccines as a functional animal-free alternative to the in vivo histamine sensitization test. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28132918&form=6&db=m Ciproxifan, a histamine H3 receptor antagonist and inverse agonist, presynaptically inhibits glutamate release in rat hippocampus. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28144998&form=6&db=m P2Y12 receptors in primary microglia activate nuclear factor of activated T-cell signaling to induce C-C chemokine 3 expression. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28145731&form=6&db=m Coupling of Airway Smooth Muscle TAS2Rs to Intracellular Signaling and Relaxation is via G?i1,2,3. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28158456&form=6&db=m The proline residue at position 319 of BvgS is essential for BvgAS activation in Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28178298&form=6&db=m The impact of prenatal exposure to parasitic infections and to anthelminthic treatment on antibody responses to routine immunisations given in infancy: Secondary analysis of a randomised controlled trial. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28181561&form=6&db=m Peripheral sensory neuron injury contributes to neuropathic pain in experimental autoimmune encephalomyelitis. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28197070&form=6&db=m Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28219737&form=6&db=m Membrane androgen receptor characteristics of human ZIP9 (SLC39A) zinc transporter in prostate cancer cells: Androgen-specific activation and involvement of an inhibitory G protein in zinc and MAP kinase signaling. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28223151&form=6&db=m Testosterone rapidly increases Ca(2+)-activated K(+) currents causing hyperpolarization in human coronary artery endothelial cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28233625&form=6&db=m Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28257236&form=6&db=m Human Rhinovirus Infection of Epithelial Cells Modulates Airway Smooth Muscle Migration. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28265351&form=6&db=m Elevated axonal membrane permeability and its correlation with motor deficits in an animal model of multiple sclerosis. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28267649&form=6&db=m Intravitreal injection of anti-Interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28277139&form=6&db=m Sphingosine-1-phosphate activates the AKT pathway to inhibit chemotherapy induced human granulosa cell apoptosis. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28277900&form=6&db=m Influence of maternal vaccination against diphtheria, tetanus, and pertussis on the avidity of infant antibody responses to a pertussis containing vaccine in Belgium. diagnostic usage,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28335677&form=6&db=m Comparison of anti-pertussis toxin ELISA and agglutination assays to assess immune responses to pertussis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28341345&form=6&db=m The signaling signature of the neurotensin type 1 receptor with endogenous ligands. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28348459&form=6&db=m Lysophosphatidic Acid Triggers Apoptosis in HeLa Cells through the Upregulation of Tumor Necrosis Factor Receptor Superfamily Member 21. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28394915&form=6&db=m Development of a qualitative assay for screening of Bordetella pertussis isolates for pertussis toxin production. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28396177&form=6&db=m Consistent induction of chronic experimental autoimmune encephalomyelitis in C57BL/6 mice for the longitudinal study of pathology and repair. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28407060&form=6&db=m Role of Osteoblast Gi Signaling in Age-Related Bone Loss in Female Mice. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28446585&form=6&db=m Activation mechanism of a neuromodulator-gated pacemaker ionic current. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28450397&form=6&db=m G protein-coupled estrogen receptor 1 (GPER1)/GPR30 increases ERK1/2 activity through PDZ motif-dependent and -independent mechanisms. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28455789&form=6&db=m Functional and structural consequences of chemokine (C-X-C motif) receptor 4 activation with cognate and non-cognate agonists. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28513461&form=6&db=m The importance of Bordetella pertussis strains which do not produce virulence factors in the epidemiology of pertussis. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28516479&form=6&db=m G?s signalling of the CB1 receptor and the influence of receptor number. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28533468&form=6&db=m Vacuolation Activity and Intracellular Trafficking of ArtB, the Binding Subunit of an AB5 Toxin Produced by Salmonella enterica Serovar Typhi. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28559440&form=6&db=m Bitter taste receptors as targets for tocolytics in preterm labor therapy. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28572615&form=6&db=m Characterization of pertussis-like toxin from Salmonella spp. that catalyzes ADP-ribosylation of G proteins. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28587283&form=6&db=m Influence of Hesperidin on the Systemic and Intestinal Rat Immune Response. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28599792&form=6&db=m A cross sectional survey measuring sero-incidence of pertussis infection among Japanese junior and senior high school students in 2013 and 2014. diagnostic usage,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28632823&form=6&db=m [Features of Bordetella pertussis, Bordetella spp. infection and whopping cough in Córdoba province, Argentina]. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28646697&form=6&db=m Seroepidemiology of whooping cough in the Czech Republic: estimates of incidence of infection in adults. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28648739&form=6&db=m G protein-coupled receptor 35 contributes to mucosal repair in mice via migration of colonic epithelial cells. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28653285&form=6&db=m Innate defense regulator IDR-1018 activates human mast cells through G protein-, phospholipase C-, MAPK- and NF-?B-sensitive pathways. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28660254&form=6&db=m CB1 allosteric modulator Org27569 is an antagonist/inverse agonist of ERK1/2 signaling. causal interaction,therapeutic application,unassigned 2,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28663369&form=6&db=m Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28668079&form=6&db=m Effects of Bu Shen Yi sui capsule on NogoA/NgR and its signaling pathways RhoA/ROCK in mice with experimental autoimmune encephalomyelitis. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28700751&form=6&db=m A high seroprevalence of antibodies to pertussis toxin among Japanese adults: Qualitative and quantitative analyses. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28707065&form=6&db=m Nasopharyngeal pertussis toxin IgA antibodies in the diagnosis of pertussis in Australian community patients. causal interaction,diagnostic usage,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28714277&form=6&db=m Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28720318&form=6&db=m Immunogenicity and protective efficacy of a newly developed tri-component diphtheria, tetanus, and acellular pertussis vaccine in a murine model. causal interaction,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28737857&form=6&db=m Seroprevalence of Bordetella pertussis among vaccinated and unvaccinated pregnant women and newborn infants in a university hospital of Buenos Aires. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28751008&form=6&db=m Molecular epidemiology of Bordetella pertussis in Cambodia determined by direct genotyping of clinical specimens. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28766743&form=6&db=m Mouse retinal ganglion cell signalling is dynamically modulated through parallel anterograde activation of cannabinoid and vanilloid pathways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28784932&form=6&db=m Fatal pertussis in the neonatal mouse model is associated with pertussis toxin-mediated pathology beyond the airways. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28836399&form=6&db=m Multiple Sclerosis Gene Therapy with Recombinant Viral Vectors: Overexpression of IL-4, Leukemia Inhibitory Factor, and IL-10 in Wharton's Jelly Stem Cells Used in EAE Mice Model. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28842544&form=6&db=m Probing the genome-scale metabolic landscape of Bordetella pertussis, the causative agent of whooping cough. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28848192&form=6&db=m Behavioral Conditioning of Immune Responses with Cyclosporine A in a Murine Model of Experimental Autoimmune Uveitis. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28857652&form=6&db=m Safety testing of acellular pertussis vaccines: use of animals and 3Rs alternatives. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28863468&form=6&db=m Effect of Prepregnancy Pertussis Vaccination in Young Infants. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28883754&form=6&db=m The activation of ?2-adrenergic receptor in the spinal cord lowers sepsis-induced mortality. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28888984&form=6&db=m Cannabidiol, a novel inverse agonist for GPR12. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28904864&form=6&db=m A G protein-coupled ?7 nicotinic receptor regulates signaling and TNF-? release in microglia. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28912160&form=6&db=m Dopamine D2 receptors modulate pyramidal neurons in mouse medial prefrontal cortex through a stimulatory G protein pathway. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28938449&form=6&db=m TSH/IGF-1 Receptor Cross-talk Rapidly Activates Extracellular Signal-regulated Kinases in Multiple Cell Types. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28940591&form=6&db=m Preliminary studies on the use of pertussis toxin for the modulation of intravaginal SIV transmission in rhesus macaques. causal interaction,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28962850&form=6&db=m Expression of membrane progesterone receptors (mPRs) in rat peripheral glial cell membranes and their potential role in the modulation of cell migration and protein expression. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28966248&form=6&db=m Pharmacological Activation Gi/o Protein Increases Glial Cell Line-Derived Neurotrophic Factor Production through Fibroblast Growth Factor Receptor and Extracellular Signal-Regulated Kinase Pathway in Primary Cultured Rat Cortical Astrocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28974234&form=6&db=m Agonists for G-protein-coupled receptor 84 (GPR84) alter cellular morphology and motility but do not induce pro-inflammatory responses in microglia. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28980823&form=6&db=m Physiopathological roles of spontaneously released outer membrane vesicles of Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29028968&form=6&db=m "Cleaved Lymphocytes" Could Be Induced by Pertussis Toxin Injection in Mice, and Are Actually Not Lymphocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29037576&form=6&db=m Pertussis seroepidemiology in women and their infants in Sarlahi District, Nepal. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29044528&form=6&db=m Endomorphins potentiate acid-sensing ion channel currents and enhance the lactic acid-mediated increase in arterial blood pressure: effects amplified in hindlimb ischaemia. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29046226&form=6&db=m Pertussis toxin IgA testing over-diagnoses recent pertussis infection. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29066131&form=6&db=m A genetically inactivated two-component acellular pertussis vaccine, alone or combined with tetanus and reduced-dose diphtheria vaccines, in adolescents: a phase 2/3, randomised controlled non-inferiority trial. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29068389&form=6&db=m Clinical Effect of IRT-5 Probiotics on Immune Modulation of Autoimmunity or Alloimmunity in the Eye. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29090869&form=6&db=m Low pertussis antibody levels in maternal and umbilical cord blood samples in Turkey. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29108883&form=6&db=m An ELISA method to estimate the mono ADP-ribosyltransferase activities: e.g in pertussis toxin and vaccines. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29122386&form=6&db=m Towards replacement of the acellular pertussis vaccine safety test: Comparison of in vitro cytotoxic activity and in vivo activity in mice. diagnostic usage,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29123207&form=6&db=m Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29141529&form=6&db=m Experimental Autoimmune Encephalomyelitis (EAE) Model of Cynomolgus Macaques Induced by Recombinant Human MOG1-125 (rhMOG1-125) Protein and MOG34-56 Peptide. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29155769&form=6&db=m A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29164393&form=6&db=m Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29172945&form=6&db=m A phase I, randomized, controlled, dose-ranging study of investigational acellular pertussis (aP) and reduced tetanus-diphtheria-acellular pertussis (TdaP) booster vaccines in adults. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29181277&form=6&db=m Antibodies to diagnostic usage,ongoing research,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29183555&form=6&db=m Enhanced diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29203889&form=6&db=m Single-molecule imaging reveals dimerization/oligomerization of CXCR4 on plasma membrane closely related to its function. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29221733&form=6&db=m Diagnostic performance of commercial serological assays measuring Bordetella pertussis IgG antibodies. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29222794&form=6&db=m Active Induction of Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29300622&form=6&db=m Differential Susceptibility of Guanine Nucleotide-binding Proteins to Pertussis Toxin-catalyzed ADP-ribosylation in Brain Membranes of Two Congeneric Marine Fishes. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29304162&form=6&db=m Adrenergic receptors inhibit TRPV1 activity in the dorsal root ganglion neurons of rats. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29314978&form=6&db=m A1 Adenosine Receptor Modulation of Adenylyl Cyclase of a Deep-living Teleost Fish, Antimora rostrata. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29324612&form=6&db=m Third-Trimester Maternal Vaccination Against Pertussis and Pertussis Antibody Concentrations. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29388727&form=6&db=m Special AT-rich sequence binding protein 1 is required for maintenance of T cell receptor responsiveness and development of experimental autoimmune encephalomyelitis. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29406469&form=6&db=m A General Lack of IgG Against Pertussis Toxin in Chinese Pregnant Women and Newborns. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29408190&form=6&db=m Seroepidemiology of diphtheria and pertussis in Chongqing, China: serology-based evidence of Bordetella pertussis infection. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29414681&form=6&db=m Metabolite-Induced Protein Expression Guided by Metabolomics and Systems Biology. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29426663&form=6&db=m Assessing the reactogenicity of Tdap vaccine administered during pregnancy and antibodies to Bordetella pertussis antigens in maternal and cord sera of Thai women. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29428395&form=6&db=m Progesterone induces relaxation of human umbilical cord vascular smooth muscle cells through mPR? (PAQR7). unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29537197&form=6&db=m EFFECT OF PEPTIDOGLYCANE OF STAPHYLOCOCCUS AUREUS CELL WALL ON THE MECHANISM OF REGULATION OF CONTRACTILE ACTIVITY OF RAT MYOMETRIUM BY ADENYLATE CYCLASE SYSTEM. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29574692&form=6&db=m P2Y therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29581192&form=6&db=m Characterization of individual human antibodies binding pertussis toxin stimulated by acellular immunization. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29592985&form=6&db=m Caffeine to prevent respiratory failure and improve outcome in infant pertussis. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29638208&form=6&db=m Investigation of the Cellular Immune Response to Recombinant Fragments of Filamentous Hemagglutinin and Pertactin of Bordetella pertussis in BALB/c Mice. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29649418&form=6&db=m Roles of progesterone receptor membrane component 1 and membrane progestin receptor alpha in regulation of zebrafish oocyte maturation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29685293&form=6&db=m Anti-IL-6 receptor antibody improves pain symptoms in mice with experimental autoimmune encephalomyelitis. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29685688&form=6&db=m Critical role of the chymase/angiotensin-(1-12) axis in modulating cardiomyocyte contractility. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29704292&form=6&db=m Modulation of hippocampal excitability via the hydroxycarboxylic acid receptor 1. causal interaction,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29723951&form=6&db=m Pharmacological Cyclophilin Inhibitors Prevent Intoxication of Mammalian Cells with Bordetella pertussis Toxin. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29738814&form=6&db=m Mucosal and systemic immune responses elicited by recombinant Lactococcus lactis expressing a fusion protein composed of pertussis toxin and filamentous hemagglutinin from Bordetella pertussis. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29749388&form=6&db=m Retraction: Murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29776413&form=6&db=m The CXCR4 antagonist plerixafor (AMD3100) promotes proliferation of Ewing sarcoma cell lines in vitro and activates receptor tyrosine kinase signaling. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29803926&form=6&db=m 5-HT1B receptor agonist CGS12066 presynaptically inhibits glutamate release in rat hippocampus. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29852172&form=6&db=m Activation of galanin receptor 1 inhibits locus coeruleus neurons via GIRK channels. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29856680&form=6&db=m Prevention of pertussis: An unresolved problem. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29869822&form=6&db=m Participation of membrane progesterone receptor ? in the inhibitory effect of progesterone on prolactin secretion. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29883692&form=6&db=m 17?-estradiol potentiates TREK1 channel activity through G protein-coupled estrogen receptor. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29898459&form=6&db=m 5-Oxo-ETE from Nasal Epithelial Cells Upregulates Eosinophil Cation Protein by Eosinophils in Nasal Polyps in vitro. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29915165&form=6&db=m Effect of Sphingosine-1-Phosphate on Intracellular Free Ca2+ in Cat Esophageal Smooth Muscle Cells. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29933735&form=6&db=m [Seroprevalence of pertussis toxin antibody in Manisa province of Turkey, after six years implementation of acellular pertussis vaccine]. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29957391&form=6&db=m Pioglitazone is superior to quetiapine, clozapine and tamoxifen at alleviating experimental autoimmune encephalomyelitis in mice. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29986044&form=6&db=m The Beta-Arrestin-Biased Dopamine D2 Receptor Ligand, UNC9994, Is a Partial Agonist at G-Protein-Mediated Potassium Channel Activation. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29986784&form=6&db=m Pertussis surveillance by small serosurveys of blood donors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30001610&form=6&db=m Neuroprotective Effects of 6-Shogaol and Its Metabolite, 6-Paradol, in a Mouse Model of Multiple Sclerosis. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30006713&form=6&db=m Active Induction of Experimental Autoimmune Encephalomyelitis (EAE) with MOG35-55 in the Mouse. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30006715&form=6&db=m Myelin Protein Zero180-199 Peptide Induced Experimental Autoimmune Neuritis in C57BL/6 Mice. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30032313&form=6&db=m N-Ethylmaleimide differentiates between the M2- and M4-autoreceptor-mediated inhibition of acetylcholine release in the mouse brain. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30037028&form=6&db=m Lupinus mutabilis Extract Exerts an Anti-Diabetic Effect by Improving Insulin Release in Type 2 Diabetic Goto-Kakizaki Rats. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30039351&form=6&db=m Mechanisms of the antilipolytic response of human adipocytes to tyramine, a trace amine present in food. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30052483&form=6&db=m The beneficial effects of 18?-glycyrrhetinic acid on the experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mouse model. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30064908&form=6&db=m The atherogenic actions of LPC on vascular smooth muscle cells and its LPA receptor mediated mechanism. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30078221&form=6&db=m Novel role of Gi?2 in cell migration: Downstream of PI3-kinase-AKT and Rac1 in prostate cancer cells. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087050&form=6&db=m Immune response to a Tdap booster in vertically HIV-infected adolescents. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30099133&form=6&db=m Probiotics and the immunological response to infant vaccinations; a double-blind randomized controlled trial. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30136189&form=6&db=m Optimization of rPDT fusion protein expression by Escherichia coli in pilot scale fermentation: a statistical experimental design approach. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30140416&form=6&db=m Subcutaneous administration of a fusion protein composed of pertussis toxin and filamentous hemagglutinin from Bordetella pertussis induces mucosal and systemic immune responses. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30148701&form=6&db=m Ginsenoside Rb1 Enhances Keratinocyte Migration by a Sphingosine-1-Phosphate-Dependent Mechanism. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30148884&form=6&db=m Activation of the Gi protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30152075&form=6&db=m Humanised monoclonal antibodies neutralise pertussis toxin by receptor blockade and reduced retrograde trafficking. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30153996&form=6&db=m Safety and efficacy of DTaP-IPV vaccine use in healthcare workers for prevention of pertussis. diagnostic usage,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30161182&form=6&db=m NOP receptor pharmacological profile - A dynamic mass redistribution study. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30208475&form=6&db=m Immunogenicity and Safety of Monovalent Acellular Pertussis Vaccine at Birth: A Randomized Clinical Trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,2 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30212033&form=6&db=m [Seroepidemiological Studies on Pertussis, Diphtheria and Tetanus among Nursing Students Enrolled between 1994 and 2011 in the Kitakyushu District]. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30219367&form=6&db=m Reactogenicity and immunogenicity of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant and nonpregnant women. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30220328&form=6&db=m The pertussis hypothesis: Bordetella pertussis colonization in the etiology of asthma and diseases of allergic sensitization. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30233409&form=6&db=m RXFP1 Receptor Activation by Relaxin-2 Induces Vascular Relaxation in Mice via a G?i2-Protein/PI3Kß/?/Nitric Oxide-Coupled Pathway. ongoing research,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30243065&form=6&db=m Anandamide inhibits Fc?RI-dependent degranulation and cytokine synthesis in mast cells through CB2 and GPR55 receptor activation. Possible involvement of CB2-GPR55 heteromers. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30261438&form=6&db=m The anaphylatoxin C3a primes model colonic epithelial cells for expression of inflammatory mediators through G?i. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30266328&form=6&db=m Genetically modified pertussis toxin: a quantum leap? unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30266329&form=6&db=m Antibody persistence after vaccination of adolescents with monovalent and combined acellular pertussis vaccines containing genetically inactivated pertussis toxin: a phase 2/3 randomised, controlled, non-inferiority trial. ongoing research,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30267661&form=6&db=m Regulation of adipogenesis by ceramide 1-phosphate. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30272557&form=6&db=m Calibration of pertussis toxin BRP batch 1 in a standardised CHO cell-based clustering assay. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30280189&form=6&db=m MrgX2?mediated internalization of LL?37 and degranulation of human LAD2 mast cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30297122&form=6&db=m Impact of maternally derived pertussis antibody titers on infant whole-cell pertussis vaccine response in a low income setting. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30298073&form=6&db=m Leptin Elicits LTC4 Synthesis by Eosinophils Mediated by Sequential Two-Step Autocrine Activation of CCR3 and PGD2 Receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30304426&form=6&db=m Association Between Third-Trimester Tdap Immunization and Neonatal Pertussis Antibody Concentration. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30381690&form=6&db=m Persistence of Antibodies against Diphtheria, Tetanus, Pertussis, and Poliovirus Types I, II, and III Following Immunization with DTaP Combined with Inactivated Wild-Type Polio Vaccine (DTaP-wIPV). ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30429789&form=6&db=m Pien Tze Huang Alleviates Relapsing-Remitting Experimental Autoimmune Encephalomyelitis Mice by Regulating Th1 and Th17 Cells. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30443943&form=6&db=m Agomelatine modulates calcium signaling through protein kinase C and phospholipase C-mediated mechanisms in rat sensory neurons. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30448334&form=6&db=m A cross-sectional study of Bordetella pertussis seroprevalence and estimated duration of vaccine protection against pertussis in St. Petersburg, Russia. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30458978&form=6&db=m Development and validation of a robust multiplex serological assay to quantify antibodies specific to pertussis antigens. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30459070&form=6&db=m Seroprevalence of pertussis among healthcare workers: A cross-sectional study from Tunisia. diagnostic usage,ongoing research,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30460079&form=6&db=m Spinal ?-adrenergic receptors' activation increases the blood glucose level in mice. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30489658&form=6&db=m Regulator of G Protein Signaling Protein 12 (Rgs12) Controls Mouse Osteoblast Differentiation via Calcium Channel/Oscillation and G?i-ERK Signaling. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30524271&form=6&db=m Cannabinoid Receptor 2 Signalling Bias Elicited by 2,4,6-Trisubstituted 1,3,5-Triazines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30534379&form=6&db=m Pharmacological profile of the neuropeptide S receptor: Dynamic mass redistribution studies. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30559337&form=6&db=m Interleukin-37 (IL-37) Suppresses Pertussis Toxin-Induced Inflammatory Myopathy in a Rat Model. causal interaction,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30591146&form=6&db=m Lysophosphatidic acid triggers cathepsin B-mediated invasiveness of human endometriotic cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30642317&form=6&db=m Acute exacerbation of idiopathic pulmonary fibrosis induced by pertussis: the first case report. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30647949&form=6&db=m Clinical and Histopathological Assessment on an Animal Model with Experimental Autoimmune Encephalomyelitis. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30651343&form=6&db=m Angiogenic Host Defense Peptide AG-30/5C and Bradykinin B2 Receptor Antagonist Icatibant Are G Protein Biased Agonists for MRGPRX2 in Mast Cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30668383&form=6&db=m Ethanol extract of Glycyrrhizae Radix modulates the responses of antigen-specific splenocytes in experimental autoimmune encephalomyelitis. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30689515&form=6&db=m Genetically detoxified pertussis toxin induces superior antigen specific CD4 T cell responses compared to chemically detoxified pertussis toxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30690077&form=6&db=m Development and Validation of Magnetic Bead Pentaplex Immunoassay for Simultaneous Quantification of murine serum IgG antibodies to Acellular Pertussis, Diphtheria and Tetanus Antigens used in combination vaccines. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30693723&form=6&db=m [Determination of tracheal cytotoxin in pertussis and diphtheria tetanus acellular pertussis vaccines using liquid chromatography-tandem mass spectrometry]. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30736722&form=6&db=m The prevention of severe pertussis and pertussis deaths in young infants. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30738084&form=6&db=m Epidermal micro-perforation potentiates the efficacy of epicutaneous vaccination. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30739093&form=6&db=m A comparison of the ability of Leu8- and Pro8-oxytocin to regulate intracellular Ca2+ and Ca2+-activated K+ channels at human and marmoset oxytocin receptors. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30739815&form=6&db=m Endocytosis of CF in marginal cells of stria vascularis regulated by ROCK and MLCK signaling cascade, but not G-proteins. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30745360&form=6&db=m Melanocortin type 4 receptor-mediated inhibition of A-type K+ current enhances sensory neuronal excitability and mechanical pain sensitivity in rats. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30758857&form=6&db=m Antibody responses to Bordetella pertussis and other childhood vaccines in infants born to mothers who received pertussis vaccine in pregnancy- a prospective, observational cohort study from the UK. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30759183&form=6&db=m Boosting Teenagers With Acellular Pertussis Vaccines Containing Recombinant or Chemically Inactivated Pertussis Toxin: A Randomized Clinical Trial. ongoing research,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30775349&form=6&db=m Development and implementation of standardized method for detecting immunogenicity of acellular pertussis vaccines in Korea. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30775352&form=6&db=m Enzyme-linked immunosorbent assay for detecting anti-pertussis toxin antibody in mouse. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30776373&form=6&db=m Signaling characteristics and functional regulation of delta opioid-kappa opioid receptor (DOP-KOP) heteromers in peripheral sensory neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30782265&form=6&db=m Pertactin-deficient Bordetella pertussis isolates: evidence of increased circulation in Europe, 1998 to 2015. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30791143&form=6&db=m The immunomodulatory effects of measles-mumps-rubella (MMR) vaccination on persistence of heterologous vaccine responses. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30793754&form=6&db=m The 112-Year Odyssey of Pertussis and Pertussis Vaccines-Mistakes Made and Implications for the Future. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30795859&form=6&db=m Dispensable role of chemokine receptors in migration of mycobacterial antigen-specific CD4+ T cells into Mycobacterium-infected lung. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30805400&form=6&db=m Subcutaneous Immunization with Recombinant Lactococcus lactis Expressing F1S1 Fusion Protein Induces Systemic and Mucosal Immune Responses in BALB/C Mice. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30808671&form=6&db=m Opioid-Mediated Modulation of Acid-Sensing Ion Channel Currents in Adult Rat Sensory Neurons. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30831450&form=6&db=m Quantitative determination of bioactive proteins in diphtheria tetanus acellular pertussis (DTaP) vaccine by liquid chromatography tandem mass spectrometry. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30863056&form=6&db=m Systemic exposure to a single dose of ferucarbotran aggravates neuroinflammation in a murine model of experimental autoimmune encephalomyelitis. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30873823&form=6&db=m A Novel Role for Somatostatin in the Survival of Mouse Pancreatic Beta Cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930008&form=6&db=m Age-related differences in antibody avidities to pertussis toxin and filamentous hemagglutinin in a healthy Japanese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30933370&form=6&db=m Nitric oxide modulates ?-opioid receptor function in vitro. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30938299&form=6&db=m Maternal pertussis vaccination and its effects on the immune response of infants aged up to 12 months in the Netherlands: an open-label, parallel, randomised controlled trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30941374&form=6&db=m A Bivalent Recombinant Mycobacterium bovis BCG Expressing the S1 Subunit of the Pertussis Toxin Induces a Polyfunctional CD4+ T Cell Immune Response. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30946562&form=6&db=m 5-HT1B Receptor-Mediated Activation of ERK1/2 Requires Both G?i/o and ?-Arrestin Proteins. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30955978&form=6&db=m Acquisition of specific antibodies and their influence on cell-mediated immune response in neonatal cord blood after maternal pertussis vaccination during pregnancy. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30962399&form=6&db=m The Rate of CD4 T Cell Entry into the Lungs during Mycobacterium tuberculosis Infection Is Determined by Partial and Opposing Effects of Multiple Chemokine Receptors. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30975754&form=6&db=m Intrinsic planar polarity mechanisms influence the position-dependent regulation of synapse properties in inner hair cells. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30995764&form=6&db=m Role of Evolutionary Selection Acting on Vaccine Antigens in the Re-Emergence of Bordetella Pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30996109&form=6&db=m Analysis of the In Vivo Transcriptome of Bordetella pertussis during Infection of Mice. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31009605&form=6&db=m Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the ?1-adrenoceptor-mediated inotropic response. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31013007&form=6&db=m Evaluation of Pertussis Toxin Expression in B2 and THIJS Media. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31024434&form=6&db=m Anti-IL-6 Receptor Antibody Inhibits Spontaneous Pain at the Pre-onset of Experimental Autoimmune Encephalomyelitis in Mice. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31036565&form=6&db=m Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31053536&form=6&db=m Vaccine acquired pertussis immunity was weakened at 4 years of age and asymptomatic pertussis infection was suspected based on serological surveillance. causal interaction,diagnostic usage,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31092580&form=6&db=m Murine Cytomegalovirus Spread Depends on the Infected Myeloid Cell Type. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31102582&form=6&db=m PARPs and PAR as novel pharmacological targets for the treatment of stress granule-associated disorders. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31173603&form=6&db=m Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31185502&form=6&db=m Higenamine, a Dual Agonist for ? 1- and ? 2-Adrenergic Receptors Identified by Screening a Traditional Chinese Medicine Library. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31189572&form=6&db=m Angiogenic and Arthritogenic Properties of the Soluble Form of CD13. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31191552&form=6&db=m Novel Targeting to XCR1+ Dendritic Cells Using Allogeneic T Cells for Polytopical Antibody Responses in the Lymph Nodes. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31215470&form=6&db=m Cholecystokinin type B receptor-mediated inhibition of A-type K+ channels enhances sensory neuronal excitability through the phosphatidylinositol 3-kinase and c-Src-dependent JNK pathway. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31228686&form=6&db=m Experimental autoimmune encephalomyelitis accelerates remyelination after lysophosphatidylcholine-induced demyelination in the corpus callosum. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31231933&form=6&db=m A binding motif for Hsp90 in the A chains of ADP-ribosylating toxins that move from the endoplasmic reticulum to the cytosol. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31233841&form=6&db=m Orexin-A protects against oxygen-glucose deprivation/reoxygenation-induced cell damage by inhibiting endoplasmic reticulum stress-mediated apoptosis via the Gi and PI3K signaling pathways. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31235524&form=6&db=m WNT-3A-induced ?-catenin signaling does not require signaling through heterotrimeric G proteins. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31252532&form=6&db=m Association of Pertussis Toxin with Severe Pertussis Disease. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31295416&form=6&db=m The evolving nature of Bordetella pertussis in Ontario, Canada, 2009-2017: strains with shifting genotypes and pertactin deficiency. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31297119&form=6&db=m In vitro Evidence of Human Immune Responsiveness Shows the Improved Potential of a Recombinant BCG Strain for Bladder Cancer Treatment. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31300611&form=6&db=m Activation of HIF-1? by ?-Opioid Receptors Induces COX-2 Expression in Breast Cancer Cells and Leads to Paracrine Activation of Vascular Endothelial Cells. causal interaction,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31319496&form=6&db=m Assays for Determining Pertussis Toxin Activity in Acellular Pertussis Vaccines. causal interaction,diagnostic usage,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31333640&form=6&db=m Pertussis Prevention: Reasons for Resurgence, and Differences in the Current Acellular Pertussis Vaccines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31333656&form=6&db=m Reactivating Immunity Primed by Acellular Pertussis Vaccines in the Absence of Circulating Antibodies: Enhanced Bacterial Control by TLR9 Rather Than TLR4 Agonist-Including Formulation. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31339586&form=6&db=m Alternative splicing event modifying ADGRL1/latrophilin-1 cytoplasmic tail promotes both opposing and dual cAMP signaling pathways. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31342459&form=6&db=m Molecular Epidemiology of Bordetella pertussis. diagnostic usage,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31349590&form=6&db=m Intracellular Trafficking and Translocation of Pertussis Toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31364527&form=6&db=m Seroprevalence of Bordetella pertussis toxin antibodies in children and adolescents in Tunis, Tunisia. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31368508&form=6&db=m Cannabichromene is a cannabinoid CB2 receptor agonist. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31376138&form=6&db=m Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis. causal interaction,therapeutic application,unassigned 3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31416049&form=6&db=m Role of mPR? (PAQR7) in progesterone-induced Ca2+ decrease in human vascular smooth muscle cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31418814&form=6&db=m Quantity and quality of antibodies after acellular versus whole cell pertussis vaccines in infants born to mothers who received Tdap during pregnancy: a randomised trial. diagnostic usage,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31450867&form=6&db=m Kainate Receptor-Mediated Depression of Glutamate Release Involves Protein Kinase A in the Cerebellum. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31451581&form=6&db=m Promiscuous G-protein coupled receptor inhibition of transient receptor potential melastatin 3 ion channels by G?? subunits. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31454418&form=6&db=m CR4056, a powerful analgesic imidazoline-2 receptor ligand, inhibits the inflammation-induced PKC? phosphorylation and membrane translocation in sensory neurons. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31454809&form=6&db=m Neuroinflammation and B-Cell Phenotypes in Cervical and Lumbosacral Regions of the Spinal Cord in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31493522&form=6&db=m Pertussis Seronegativity in Pregnant Women in the City of Al Ain, United Arab Emirates. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31494202&form=6&db=m Identification of novel phytocannabinoids from Ganoderma by label-free dynamic mass redistribution assay. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31506300&form=6&db=m Sonic hedgehog enhances calcium oscillations in hippocampal astrocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31522437&form=6&db=m Evaluation of IL-17 Serum Level, Brain Inflammation and Demyelination in Experimental Autoimmune Encephalomyelitis C57BL/6 Mice Model with Different Doses of Myelin Oligodendrocyte Glycoprotein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31526657&form=6&db=m Collaborative study for the calibration of the replacement International Standard for pertussis toxin for use in histamine sensitisation and CHO cell clustering assays. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31537990&form=6&db=m Schizophrenia Plasma Autoantibodies Promote 'Biased Agonism' at the 5-Hydroxytryptamine 2A Receptor: Neurotoxicity is Positively Modulated by Metabotropic Glutamate 2/3 Receptor Agonism. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31546599&form=6&db=m Pertussis Toxin: A Key Component in Pertussis Vaccines? ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31547158&form=6&db=m Genetic Variation in the Magnitude and Longevity of the IgG Subclass Response to a Diphtheria-Tetanus-Acellular Pertussis (DTaP) Vaccine in Mice. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31610300&form=6&db=m Assessment of IgA anti-PT and IgG anti-ACT reflex testing to improve Bordetella pertussis serodiagnosis in recently vaccinated subjects. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31627764&form=6&db=m Seroprevalence of an antibody against diphtheria, tetanus, and pertussis among the elderly in Khon Kaen, Thailand. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31638216&form=6&db=m C?type natriuretic peptide prevents angiotensin II?induced atrial connexin 40 and 43 dysregulation by activating AMP?activated kinase signaling. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31653054&form=6&db=m Suppression of the Peripheral Immune System Limits the Central Immune Response Following Cuprizone-Feeding: Relevance to Modelling Multiple Sclerosis. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31681214&form=6&db=m AhR Activation by TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin) Attenuates Pertussis Toxin-Induced Inflammatory Responses by Differential Regulation of Tregs and Th17 Cells Through Specific Targeting by microRNA. causal interaction,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31704717&form=6&db=m Thyrotropin Causes Dose-dependent Biphasic Regulation of cAMP Production Mediated by Gs and Gi/o Proteins. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31715185&form=6&db=m Mechanistic insights into ?-opioid-induced cardioprotection: Involvement of caveolin translocation to the mitochondria. ongoing research,therapeutic application,unassigned 4,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31721379&form=6&db=m Expression and function of umami receptors T1R1/T1R3 in gastric smooth muscle. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31731820&form=6&db=m Trends in Hospital Admissions for Pertussis Infection: A Nationwide Retrospective Observational Study in Italy, 2002-2016. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31769735&form=6&db=m Population dynamics and antigenic drift of Bordetella pertussis following whole cell vaccine replacement, Barcelona, Spain, 1986-2015. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31775826&form=6&db=m Differential regulation of Cav2.2 channel exon 37 variants by alternatively spliced ?-opioid receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31778110&form=6&db=m Engineering of an Iranian Bordetella pertussis strain producing inactive pertussis toxin. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31780940&form=6&db=m Ghrelin Attenuates Neuroinflammation and Demyelination in Experimental Autoimmune Encephalomyelitis Involving NLRP3 Inflammasome Signaling Pathway and Pyroptosis. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31811326&form=6&db=m Selective protection of murine cerebral Gi/o-proteins from inactivation by parenterally injected pertussis toxin. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31830622&form=6&db=m HIV-1 Tat protein attenuates the clinical course of experimental autoimmune encephalomyelitis (EAE). ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31831431&form=6&db=m Designing a new multi-epitope pertussis vaccine with highly population coverage based on a novel sequence and structural filtration algorithm. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31863923&form=6&db=m Beneficial role of simvastatin in experimental autoimmune myositis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31899865&form=6&db=m Discovery of Compounds Inhibiting the ADP-Ribosyltransferase Activity of Pertussis Toxin. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31907536&form=6&db=m Functionally Selective Inhibition of the Oxytocin Receptor by Retosiban in Human Myometrial Smooth Muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31920979&form=6&db=m CRF1 Receptor Signaling via the ERK1/2-MAP and Akt Kinase Cascades: Roles of Src, EGF Receptor, and PI3-Kinase Mechanisms. causal interaction,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31937256&form=6&db=m Pertussis in infants, in their mothers and other contacts in Casablanca, Morocco. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31941716&form=6&db=m Leukotriene B4 Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31945121&form=6&db=m Evaluation of inactivated Bordetella pertussis as a delivery system for the immunization of mice with Pneumococcal Surface Antigen A. causal interaction,therapeutic application,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31958947&form=6&db=m Temporally Coarse-Grained All-Atom Molecular Dynamics Achieved via Stochastic Padé Approximants. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31960801&form=6&db=m Protective effects of pharmacological therapies in animal models of multiple sclerosis: a review of studies 2014-2019. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31965656&form=6&db=m Role of PKC?-NADPH oxidase signaling axis in PKC?-mediated Gi?2 phosphorylation for inhibition of adenylate cyclase activity by angiotensin II in pulmonary artery smooth muscle cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32007501&form=6&db=m Antidepressants induce profibrotic responses via the lysophosphatidic acid receptor LPA1. ongoing research,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32007705&form=6&db=m Maraviroc attenuates the pathogenesis of experimental autoimmune encephalitis. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32009055&form=6&db=m An investigation of Japanese neonatal and maternal antibody status against pertussis. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32053508&form=6&db=m Seroprevalence of antibodies for pertussis and diphtheria among people leaving or entering China: a cross-sectional study. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32067048&form=6&db=m Waning vaccine immunity and vaccination responses in children treated for acute lymphoblastic leukemia: A Canadian Immunization Research Network Study. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32076653&form=6&db=m Neutralization of pertussis toxin by a single antibody prevents clinical pertussis in neonatal baboons. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32088264&form=6&db=m Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32108565&form=6&db=m Optimization of sample preparation for culture-independent sequencing of Bordetella pertussis. causal interaction,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32152757&form=6&db=m D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32171577&form=6&db=m Dynamics of pertussis toxin IgG after symptomatic pertussis in children and adults. diagnostic usage,therapeutic application,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32172302&form=6&db=m Bitter taste receptors stimulate phagocytosis in human macrophages through calcium, nitric oxide, and cyclic-GMP signaling. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32186151&form=6&db=m Protective effects of catalpol and rhein in murine experimental autoimmune encephalomyelitis via regulation of T helper (Th) 1, Th2, Th17, and regulatory T cell responses. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32190153&form=6&db=m Differential effect of adenosine on rhabdomyosarcoma migration and proliferation. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32209026&form=6&db=m The short-chain free fatty acid receptor FFAR3 is expressed and potentiates contraction in human airway smooth muscle. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32209694&form=6&db=m Bordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses CaV3.1 as the Cell Surface Receptor. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32210765&form=6&db=m CD8 T-cell Recruitment Into the Central Nervous System of Cuprizone-Fed Mice: Relevance to Modeling the Etiology of Multiple Sclerosis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32219433&form=6&db=m Per- and Polyfluoroalkyl Substances Differentially Inhibit Placental Trophoblast Migration and Invasion In Vitro. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32230963&form=6&db=m Multiplex Point-of-Care Tests for the Determination of Antibodies after Acellular Pertussis Vaccination. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32272531&form=6&db=m Involvement of Protein Kinase C and RhoA in Protease-Activated Receptor 1-Mediated F-Actin Reorganization and Cell Growth in Rat Cardiomyocytes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32301060&form=6&db=m Lysophosphatidic acid receptor-2 (LPA2)-mediated signaling enhances chemoresistance in melanoma cells treated with anticancer drugs. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32322373&form=6&db=m Genome diversity and evolutionary characteristics of clinical isolates of Bordetella pertussis circulating in Iran. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32322378&form=6&db=m A novel method for the extraction of outer membrane vesicles (OMVs) from Bordetella pertussis Tohama strain. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32334951&form=6&db=m Allele frequencies of Bordetella pertussis virulence-associated genes identified from pediatric patients with severe respiratory infections. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32362310&form=6&db=m Metronidazole Attenuates the Intensity of Inflammation in Experimental Autoimmune Uveitis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32387447&form=6&db=m Seroprevalence of antibodies against diphtheria, tetanus, and pertussis among healthy Thai adolescents. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32399401&form=6&db=m Sensitized heat shock protein 27 induces retinal ganglion cells apoptosis in rat glaucoma model. ongoing research,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32401811&form=6&db=m Multiple weak interactions between BvgA~P and ptx promoter DNA strongly activate transcription of pertussis toxin genes in Bordetella pertussis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32425890&form=6&db=m TSH Receptor Homodimerization in Regulation of cAMP Production in Human Thyrocytes in vitro. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32481675&form=6&db=m Development and Characterization of an Allergic Asthma Rat Model for Interventional Studies. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32500188&form=6&db=m Involvement of Gi protein-dependent BKCa channel activation in ?2-adrenoceptor-mediated dilation of retinal arterioles in rats. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32599609&form=6&db=m Impact of pertussis-specific IgA, IgM, and IgG antibodies in mother's own breast milk and donor breast milk during preterm infant digestion. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32602465&form=6&db=m Toward an Alum Free Mono-Component Monovalent Pertussis Vaccine: A Cytokine Response Assay. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32627115&form=6&db=m The role of spinally located dopamine D2 receptors in the regulation of the blood glucose level in mice. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32676009&form=6&db=m Pertussis Toxin Ameliorates Microglial Activation Associated With Ischemic Stroke. causal interaction,ongoing research,unassigned 4,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32688029&form=6&db=m Chronic mechanical hypersensitivity in experimental autoimmune encephalomyelitis is regulated by disease severity and neuroinflammation. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32691700&form=6&db=m Computational evaluation of a fusion protein consisted of pertussis toxin and filamentous hemagglutinin from Bordetella pertussis to target Claudin-4 using C-terminal fragment of Clostridium perfringens enterotoxin. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32709433&form=6&db=m Kinetics of maternal pertussis-specific antibodies in infants of mothers vaccinated with tetanus, diphtheria and acellular pertussis (Tdap) during pregnancy. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32717772&form=6&db=m Serum-borne lipids amplify TLR-activated inflammatory responses. causal interaction,therapeutic application,unassigned 1,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32719460&form=6&db=m ?-hydroxybutyrate and hydroxycarboxylic acid receptor 2 agonists activate the AKT, ERK and AMPK pathways, which are involved in bovine neutrophil chemotaxis. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32759959&form=6&db=m Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibits robust immunogenicity. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32765879&form=6&db=m Differences in epitope-specific antibodies to pertussis toxin after infection and acellular vaccinations. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32793765&form=6&db=m Low Detection Rate of Bordetella pertussis Using the BioFire FilmArray Respiratory Panel 2plus. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32803840&form=6&db=m Histone H4 directly stimulates neutrophil activation through membrane permeabilization. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32812134&form=6&db=m Kombucha ameliorates experimental autoimmune encephalomyelitis through activation of Treg and Th2 cells. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32817719&form=6&db=m T cell and chemokine receptors differentially control CD8 T cell motility behavior in the infected airways immediately before and after virus clearance in a primary infection. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32825350&form=6&db=m Melatonin Suppresses the Kainate Receptor-Mediated Excitation on Gonadotropin-Releasing Hormone Neurons in Female and Male Prepubertal Mice. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32831029&form=6&db=m Establishment and application of a multiple cross displacement amplification combined with nanoparticles-based biosensor method for the detection of Bordetella pertussis. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32855863&form=6&db=m Systemic Mesenchymal Stem Cell Treatment Mitigates Structural and Functional Retinal Ganglion Cell Degeneration in a Mouse Model of Multiple Sclerosis. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32858414&form=6&db=m The effects of manufacture processes on post-translational modifications of bioactive proteins in pertussis vaccine. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32871475&form=6&db=m A new lipophilic amino alcohol, chemically similar to compound FTY720, attenuates the pathogenesis of experimental autoimmune encephalomyelitis by PI3K/Akt pathway inhibition. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32872778&form=6&db=m Single-Peptide TR-FRET Detection Platform for Cysteine-Specific Post-Translational Modifications. ongoing research,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32883524&form=6&db=m Cooperation of G12/13 and Gi proteins via lysophosphatidic acid receptor-2 (LPA2) signaling enhances cancer cell survival to cisplatin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32896653&form=6&db=m Safety and immunogenicity of the epicutaneous reactivation of pertussis toxin immunity in healthy adults: a phase I, randomized, double-blind, placebo-controlled trial. ongoing research,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32908412&form=6&db=m Egg Envelope Glycoproteins ZP1 and ZP3 Mediate Sperm-Egg Interaction in the Japanese Quail. diagnostic usage,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32930758&form=6&db=m Association of Routine Infant Vaccinations With Antibody Levels Among Preterm Infants. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32948812&form=6&db=m Ascorbate-induced oxidative stress mediates TRP channel activation and cytotoxicity in human etoposide-sensitive and -resistant retinoblastoma cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32961171&form=6&db=m Neferine, a bisbenzylisoquinoline alkaloid of Nelumbo nucifera, inhibits glutamate release in rat cerebrocortical nerve terminals through 5-HT1A receptors. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32966754&form=6&db=m Nociceptin/Orphanin FQ peptide receptor (NOP) mediates inhibition of N-type calcium currents in vestibular afferent neurons of the rat. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33020504&form=6&db=m FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33023902&form=6&db=m Effect of resolvins on sensitisation of TRPV1 and visceral hypersensitivity in IBS. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33049367&form=6&db=m Cannabinoid receptor subtype influence on neuritogenesis in human SH-SY5Y cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33059000&form=6&db=m The quantitative analysis of the mechanism involved in pertussis toxin-mediated cell clustering and its implications in the in vitro quality control of diphtheria tetanus and whole cell pertussis vaccines. ongoing research,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33088168&form=6&db=m Tofacitinib inhibits the development of experimental autoimmune uveitis and reduces the proportions of Th1 but not of Th17 cells. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33117177&form=6&db=m Voltage-Dependent Dopamine Potency at D1-Like Dopamine Receptors. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33118159&form=6&db=m Lysophosphatidic acid induces thrombospondin-1 production in primary cultured rat cortical astrocytes. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33129237&form=6&db=m Recombinant Production of a Novel Fusion Protein: Listeriolysin O Fragment Fused to S1 Subunit of Pertussis Toxin. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33147407&form=6&db=m iGIST-A Kinetic Bioassay for Pertussis Toxin Based on Its Effect on Inhibitory GPCR Signaling. ongoing research,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33152337&form=6&db=m Functional evidence for biased inhibition of G protein signaling by YM-254890 in human coronary artery endothelial cells. diagnostic usage,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33172018&form=6&db=m AGS3 and G?i3 Are Concomitantly Upregulated as Part of the Spindle Orientation Complex during Differentiation of Human Neural Progenitor Cells. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33176935&form=6&db=m Enhanced post-licensure safety surveillance of a new recombinant acellular pertussis vaccine licensed as a monovalent (aP, Pertagen®) and tetanus, reduced-dose diphtheria combination (TdaP, Boostagen®) vaccine for immunization of adolescents and adults in Thailand. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33178692&form=6&db=m ?2-Adrenergic Disruption of ? Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33182064&form=6&db=m Amifostine ameliorates induction of experimental autoimmune encephalomyelitis: Effect on reactive oxygen species/NLRP3 pathway. ongoing research,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33189793&form=6&db=m Titration of myelin oligodendrocyte glycoprotein (MOG) - Induced experimental autoimmune encephalomyelitis (EAE) model. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33190849&form=6&db=m Sex differences in EAE reveal common and distinct cellular and molecular components. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33195147&form=6&db=m Human Salivary Histatin-1 Promotes Osteogenic Cell Spreading on Both Bio-Inert Substrates and Titanium SLA Surfaces. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33195366&form=6&db=m Short Chain Fatty Acids Enhance Expression and Activity of the Umami Taste Receptor in Enteroendocrine Cells via a G?i/o Pathway. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33197362&form=6&db=m Adequate tetanus but poor diphtheria and pertussis response to a Tdap booster in adolescents with juvenile systemic lupus erythematosus. diagnostic usage,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33230972&form=6&db=m Sphingosylphosphorylcholine blocks ovariectomy-induced bone loss by suppressing Ca2+ /calmodulin-mediated osteoclast differentiation. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33259004&form=6&db=m Prenatal Stress Impairs Spinal Cord Oligodendrocyte Maturation via BDNF Signaling in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33295881&form=6&db=m FSH directly regulates chondrocyte dedifferentiation and cartilage development. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33298313&form=6&db=m Structurally different lysophosphatidylethanolamine species stimulate neurite outgrowth in cultured cortical neurons via distinct G-protein-coupled receptors and signaling cascades. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33363467&form=6&db=m Anti-Inflammatory Effect of Geniposide on Regulating the Functions of Rheumatoid Arthritis Synovial Fibroblasts via Inhibiting Sphingosine-1-Phosphate Receptors1/3 Coupling G?i/G?s Conversion. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33403844&form=6&db=m Anti-inflammatory Activity of Caspian Cobra (Naja naja oxiana) Snake Venom on the Serum Level of Interleukin-27 and Histopathological Changes in Myelin Oligodendrocyte Glycoprotein-experimental Autoimmune Encephalomyelitisinduced Mice. causal interaction,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33428887&form=6&db=m Fingolimod inhibits glutamate release through activation of S1P1 receptors and the G protein ?? subunit-dependent pathway in rat cerebrocortical nerve terminals. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33442562&form=6&db=m MrgprX1 Mediates Neuronal Excitability and Itch Through Tetrodotoxin-Resistant Sodium Channels. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33470435&form=6&db=m Does Bordetella pertussis vaccine offer any cross-protection against Bordetella bronchiseptica? Implications for pet owners with cystic fibrosis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33478788&form=6&db=m Tdap booster to adolescents with juvenile idiopathic arthritis on and off anti-TNF agents is safe and immunogenic. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33482358&form=6&db=m Autoimmune experimental orchitis and chronic glomerulonephritis with end stage renal disease are controlled by Cgnz1 for susceptibility to end organ damage. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33484949&form=6&db=m Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33489011&form=6&db=m Structure and compositional analysis of aluminum oxyhydroxide adsorbed pertussis vaccine. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33494474&form=6&db=m Extra Virgin Olive Oil Phenols Vasodilate Rat MesentericResistance Artery via Phospholipase C (PLC)-CalciumMicrodomains-Potassium Channels (BKCa) Signals. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33513780&form=6&db=m Simultaneous Determination of Antibodies to Pertussis Toxin and Adenylate Cyclase Toxin Improves Serological Diagnosis of Pertussis. diagnostic usage,therapeutic application,unassigned 4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33517831&form=6&db=m Decline of serologic immunity to diphtheria, tetanus and pertussis with age suggested a full life vaccination in mainland China. diagnostic usage,ongoing research,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33535610&form=6&db=m Phosphatidic Acid Stimulates Myoblast Proliferation through Interaction with LPA1 and LPA2 Receptors. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33589299&form=6&db=m An observational study of antibody responses to a primary or subsequent pertussis booster vaccination in Australian healthcare workers. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33635165&form=6&db=m G?i-biased apelin analog protects against isoproterenol-induced myocardial dysfunction in rats. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33642160&form=6&db=m Seroepidemiology of pertussis in China: A population-based, cross-sectional study. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33647770&form=6&db=m Responses to an acellular pertussis booster vaccination in children, adolescents, and young and older adults: A collaborative study in Finland, the Netherlands, and the United Kingdom. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33653842&form=6&db=m Angioedema as a predominant symptom of Bordetella pertussis infection. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33678454&form=6&db=m Determination of serum neutralizing antibodies reveals important difference in quality of antibodies against pertussis toxin in children after infection. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33686161&form=6&db=m Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo. ongoing research,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33708809&form=6&db=m Endothelin-1 Upregulates Activin Receptor-Like Kinase-1 Expression via Gi/RhoA/Sp-1/Rho Kinase Pathways in Human Pulmonary Arterial Endothelial Cells. ongoing research,therapeutic application,unassigned 1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33720984&form=6&db=m Application of xCELLigence real-time cell analysis to the microplate assay for pertussis toxin induced clustering in CHO cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33768674&form=6&db=m Isovaleric acid ameliorates ovariectomy-induced osteoporosis by inhibiting osteoclast differentiation. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33769247&form=6&db=m Investigation of a pertussis outbreak and comparison of two acellular booster pertussis vaccines in a junior school in South East England, 2019. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33805762&form=6&db=m Pertussis Toxin Inhibits Encephalitogenic T-Cell Infiltration and Promotes a B-Cell-Driven Disease during Th17-EAE. therapeutic application,unassigned 4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33806201&form=6&db=m Oxytocin Downregulates the CaV1.2 L-Type Ca2+ Channel via Gi/cAMP/PKA/CREB Signaling Pathway in Cardiomyocytes. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33811988&form=6&db=m Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to ?-arrestin 2. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33812087&form=6&db=m Meibomian gland dysfunction is suppressed via selective inhibition of immune responses by topical LFA-1/ICAM antagonism with lifitegrast in the allergic eye disease (AED) model. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33815369&form=6&db=m Göttingen Minipigs as a Model to Evaluate Longevity, Functionality, and Memory of Immune Response Induced by Pertussis Vaccines. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33815654&form=6&db=m Bu Shen Yi Sui Capsule Alleviates Neuroinflammation and Demyelination by Promoting Microglia toward M2 Polarization, Which Correlates with Changes in miR-124 and miR-155 in Experimental Autoimmune Encephalomyelitis. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33851697&form=6&db=m TSH Activates Macrophage Inflammation by G13- and G15-dependent Pathways. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33857254&form=6&db=m Neuromedin U uses G?i2 and G?o to suppress glucose-stimulated Ca2+ signaling and insulin secretion in pancreatic ? cells. ongoing research,therapeutic application,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33910203&form=6&db=m Characterization of a Rat Model of Myeloperoxidase-Anti-Neutrophil Cytoplasmic Antibody-Associated Crescentic Glomerulonephritis. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33928900&form=6&db=m Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019. diagnostic usage,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33931696&form=6&db=m Four single-basepair mutations in the ptx promoter of Bordetella bronchiseptica are sufficient to activate the expression of pertussis toxin. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33934749&form=6&db=m Establishment of Pertussis toxin BRP batch 2 for CHO clustering assay. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34001895&form=6&db=m Circulation of pertussis and poor protection against diphtheria among middle-aged adults in 18 European countries. causal interaction,diagnostic usage,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34045505&form=6&db=m GRK2 contributes to glucose mediated calcium responses and insulin secretion in pancreatic islet cells. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34064136&form=6&db=m Expression of Bordetella pertussis Antigens Fused to Different Vectors and Their Effectiveness as Vaccines. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34108881&form=6&db=m Dexmedetomidine Inhibits ASIC Activity via Activation of ?2A Adrenergic Receptors in Rat Dorsal Root Ganglion Neurons. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34120372&form=6&db=m Pertussis seroprevalence among adults of reproductive age (20-39 years) in fourteen European countries. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34145457&form=6&db=m Pertussis toxin promotes pulmonary hypertension in an infant mouse model of Bordetella pertussis infection. causal interaction,therapeutic application,unassigned 3,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34167200&form=6&db=m Dual Transmembrane Signalling Mechanisms in Eosinophils: Evidence for Two Functionally Distinct Receptors for Platelet-Activating Factor. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34167220&form=6&db=m IL-3 Primes and Evokes Histamine Release from Human Basophils but not Mast Cells. causal interaction,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34230558&form=6&db=m Untangling the genetic link between type 1 and type 2 diabetes using functional genomics. causal interaction,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34237428&form=6&db=m FSH mediated cAMP signalling upregulates the expression of G? subunits in pubertal rat Sertoli cells. causal interaction,therapeutic application,unassigned 3,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34276113&form=6&db=m Antibodies induced by oral immunization of mice with a recombinant protein produced in tobacco plants harboring Bordetella pertussis epitopes. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34293825&form=6&db=m Kainate receptor modulation of glutamatergic synaptic transmission in the CA2 region of the hippocampus. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34305922&form=6&db=m The Effect of Tetanus-Diphtheria-Acellular-Pertussis Immunization During Pregnancy on Infant Antibody Responses: Individual-Participant Data Meta-Analysis. therapeutic application,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34310708&form=6&db=m Vascular and immunopathological role of Asymmetric Dimethylarginine (ADMA) in Experimental Autoimmune Encephalomyelitis. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34341068&form=6&db=m Pertussis toxin-induced inflammatory response exacerbates intracerebral haemorrhage and ischaemic stroke in mice. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34342984&form=6&db=m In Vivo Dissection of Two Intracellular Pathways Involved in the Spinal Oxytocin-Induced Antinociception in the Rat. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34343132&form=6&db=m Targeting Gi/o protein-coupled receptor signaling blocks HER2-induced breast cancer development and enhances HER2-targeted therapy. ongoing research,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34357952&form=6&db=m Human Peptides ?-Defensin-1 and -5 Inhibit Pertussis Toxin. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34386749&form=6&db=m Antibody persistence 2 and 3 years after booster vaccination of adolescents with recombinant acellular pertussis monovalent aPgen or combined TdaPgen vaccines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34407803&form=6&db=m Molecular epidemiology of Bordetella pertussis and analysis of vaccine antigen genes from clinical isolates from Shenzhen, China. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34437379&form=6&db=m Evaluation of Anti-PT Antibody Response after Pertussis Vaccination and Infection: The Importance of Both Quantity and Quality. causal interaction,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34437436&form=6&db=m In Vivo Models and In Vitro Assays for the Assessment of Pertussis Toxin Activity. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34437445&form=6&db=m Secretion of Pertussis Toxin from Bordetella pertussis. causal interaction,ongoing research,unassigned 2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34465476&form=6&db=m Estimating Bordetella pertussis seroprevalence in adolescents and young adults in Mexico using the 2012 National Health and Nutrition Survey (ENSANUT). diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34476771&form=6&db=m A New Electrochemiluminescence-Based Multiplex Assay for the Assessment of Human Antibody Responses to Bordetella pertussis Vaccines. diagnostic usage,therapeutic application,unassigned 2,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34479491&form=6&db=m Study protocol of the PIMPI-project, a cohort study on acceptance, tolerability and immunogenicity of second trimester maternal pertussis immunization in relation to term and preterm infants. diagnostic usage,unassigned 1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34493192&form=6&db=m Outer Membrane Vesicles of Bordetella pertussis encapsulated into sodium alginate nanoparticles as novel vaccine delivery system. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34494943&form=6&db=m Microbiota metabolite butyrate constrains neutrophil functions and ameliorates mucosal inflammation in inflammatory bowel disease. therapeutic application,unassigned 2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34511302&form=6&db=m Duration of protection against Bordetella pertussis infection elicited by whole-cell and acellular vaccine priming in Polish children and adolescents. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34533118&form=6&db=m Evolution of Bordetella pertussis over a 23-year period in France, 1996 to 2018. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34534737&form=6&db=m Pertussis antibody levels in infants and their mothers receiving combined tetanus-diphtheria toxoid and acellular pertussis vaccine during pregnancy in Turkey. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34536591&form=6&db=m Inhibitory G protein-mediated modulation of slow delayed rectifier potassium channels contributes to increased susceptibility to arrhythmogenesis in aging heart. therapeutic application,unassigned 3,0 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34536757&form=6&db=m Quantification of kappa opioid receptor ligand potency, efficacy and desensitization using a real-time membrane potential assay. unassigned - 2.4.2.30 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100108581&form=6&db=m Involvement of G-proteins in chitosan-induced Anthraquinone synthesis in Rubia tinctorum diagnostic usage,unassigned 1,0 2.4.2.30 Wound Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8656619&form=6&db=m Production of extracellular virulence factors by Pseudomonas aeruginosa isolates obtained from tracheal, urinary tract, and wound infections. causal interaction,unassigned 3,0 2.4.2.30 Wound Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10582188&form=6&db=m Pseudomonas aeruginosa strains obtained from patients with tracheal, urinary tract and wound infection: variations in virulence factors and virulence genes. causal interaction,therapeutic application,unassigned 1,2,0 2.4.2.30 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9607915&form=6&db=m Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice. unassigned - 2.4.2.30 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23038248&form=6&db=m Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repair. unassigned - 2.4.2.30 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23319653&form=6&db=m Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair. unassigned - 2.4.2.30 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26880244&form=6&db=m Xeroderma Pigmentosum Group A Promotes Autophagy to Facilitate Cisplatin Resistance in Melanoma Cells through the Activation of PARP1. causal interaction,therapeutic application,unassigned 3,4,0 2.4.2.30 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27521476&form=6&db=m Kinetics and thermodynamics of zinc(II) and arsenic(III) binding to XPA and PARP-1 zinc finger peptides. unassigned - 2.4.2.30 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27624574&form=6&db=m PARP10 deficiency manifests by severe developmental delay and DNA repair defect. causal interaction,unassigned 4,0 2.4.2.30 Zika Virus Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31539774&form=6&db=m PARP-1 mediated cell death is directly activated by ZIKV infection. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.4.2.30 Zika Virus Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34187568&form=6&db=m ADP-ribosyltransferase PARP11 suppresses Zika virus in synergy with PARP12. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0