2.4.1.223 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11382776&form=6&db=m A novel endo-beta-galactosidase from Clostridium perfringens that liberates the disaccharide GlcNAcalpha 1-->Gal from glycans specifically expressed in the gastric gland mucous cell-type mucin. ongoing research,unassigned 1,0 2.4.1.223 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32347583&form=6&db=m Aberrant glycosaminoglycan biosynthesis by tumor suppressor EXTL2 deficiency promotes liver inflammation and tumorigenesis through Toll-like 4 receptor signaling. causal interaction,ongoing research,unassigned 4,1,0 2.4.1.223 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32703234&form=6&db=m The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination. unassigned - 2.4.1.223 Exostoses, Multiple Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11121397&form=6&db=m rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate. causal interaction,unassigned 1,0 2.4.1.223 Exostoses, Multiple Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17237233&form=6&db=m Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis. causal interaction,ongoing research,unassigned 1,1,0 2.4.1.223 glucuronosyl-galactosyl-proteoglycan 4-alpha-n-acetylglucosaminyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32347583&form=6&db=m Aberrant glycosaminoglycan biosynthesis by tumor suppressor EXTL2 deficiency promotes liver inflammation and tumorigenesis through Toll-like 4 receptor signaling. causal interaction,ongoing research,unassigned 4,1,0 2.4.1.223 Kashin-Beck Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32517548&form=6&db=m Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease. causal interaction,diagnostic usage,unassigned 2,1,0 2.4.1.223 Mucopolysaccharidoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19690583&form=6&db=m Gene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses. therapeutic application,unassigned 4,0 2.4.1.223 Mucopolysaccharidosis III http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19690583&form=6&db=m Gene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses. therapeutic application,unassigned 4,0 2.4.1.223 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10318803&form=6&db=m The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate. causal interaction,unassigned 1,0 2.4.1.223 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11121397&form=6&db=m rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate. causal interaction,unassigned 1,0 2.4.1.223 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17237233&form=6&db=m Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis. causal interaction,ongoing research,unassigned 1,1,0 2.4.1.223 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23395820&form=6&db=m EXTL2, a Member of the EXT Family of Tumor Suppressors, Controls Glycosaminoglycan Biosynthesis in a Xylose Kinase-dependent Manner. unassigned - 2.4.1.223 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23734945&form=6&db=m Roles of EXTL2, a member of the EXT family of tumour suppressors, in liver injury and regeneration processes. unassigned - 2.4.1.223 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32347583&form=6&db=m Aberrant glycosaminoglycan biosynthesis by tumor suppressor EXTL2 deficiency promotes liver inflammation and tumorigenesis through Toll-like 4 receptor signaling. causal interaction,ongoing research,unassigned 4,1,0 2.4.1.223 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32703234&form=6&db=m The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination. unassigned - 2.4.1.223 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32517548&form=6&db=m Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease. causal interaction,diagnostic usage,unassigned 2,1,0 2.4.1.223 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16441422&form=6&db=m Clinical utility of quantitative RT-PCR targeted to alpha1,4-N-acetylglucosaminyltransferase mRNA for detection of pancreatic cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0 2.4.1.223 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12594234&form=6&db=m Usefulness of the real-time reverse transcription-polymerase chain reaction assay targeted to alpha1,4-N-acetylglucosaminyltransferase for the detection of gastric cancer. diagnostic usage,unassigned 4,0