2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25607838&form=6&db=m Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury. unassigned - 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25668000&form=6&db=m Acute kidney injury: Sirtuin 3-a master regulator of mitochondrial integrity in AKI. unassigned - 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27599451&form=6&db=m Melatonin prevents acute kidney injury in severely burned rats via the activation of SIRT1. unassigned - 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28852469&form=6&db=m Ginkgetin aglycone ameliorates LPS-induced acute kidney injury by activating SIRT1 via inhibiting the NF-?B signaling pathway. unassigned - 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31400413&form=6&db=m Porous Se@SiO2 nanospheres attenuate cisplatin-induced acute kidney injury via activation of Sirt1. unassigned - 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31402864&form=6&db=m Resveratrol Protects Against Post-Contrast Acute Kidney Injury in Rabbits With Diabetic Nephropathy. unassigned - 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33307898&form=6&db=m MicroRNA-499-5p targets SIRT1 to aggravate lipopolysaccharide-induced acute lung injury. unassigned - 2.3.1.286 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33489803&form=6&db=m Hsa_circ_0006571 promotes spinal metastasis through sponging microRNA-138 to regulate sirtuin 1 expression in lung adenocarcinoma. unassigned - 2.3.1.286 Adenoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23299244&form=6&db=m SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain. unassigned - 2.3.1.286 Adrenoleukodystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26073123&form=6&db=m Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: A paradigm for axonal degeneration. unassigned - 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19104446&form=6&db=m Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. unassigned - 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26045440&form=6&db=m Mitochondrial Sirt3 Expression is Decreased in APP/PS1 Double Transgenic Mouse Model of Alzheimer's Disease. unassigned - 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26275347&form=6&db=m Peripheral leukocyte expression of the potential biomarker proteins Bdnf, Sirt1, and Psen1 is not regulated by promoter methylation in Alzheimer's disease patients. unassigned - 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29865070&form=6&db=m Honokiol Alleviates Cognitive Deficits of Alzheimer's Disease (PS1V97L) Transgenic Mice by Activating Mitochondrial SIRT3. unassigned - 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31818974&form=6&db=m SIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer's Disease Model. unassigned - 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32967533&form=6&db=m Mitophagy in degenerative joint diseases. unassigned - 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34407393&form=6&db=m Icariin ameliorate Alzheimer's disease by influencing SIRT1 and inhibiting A? cascade pathogenesis. unassigned - 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25167838&form=6&db=m SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system. unassigned - 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28239025&form=6&db=m The role of single-nucleotide variants of the energy metabolism-linked genes SIRT3, PPARGC1A and APOE in amyotrophic lateral sclerosis risk. unassigned - 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30295421&form=6&db=m SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis. unassigned - 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32459877&form=6&db=m Identification and verification of key genes in varicocele rats through high-throughput sequencing and bioinformatics analysis. unassigned - 2.3.1.286 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29524861&form=6&db=m Abnormal acetylation of FOXP3 regulated by SIRT-1 induces Treg functional deficiency in patients with abdominal aortic aneurysms. unassigned - 2.3.1.286 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25739523&form=6&db=m Antiasthmatic Effects of Resveratrol in Ovalbumin-Induced Asthma Model Mice Involved in the Upregulation of PTEN. unassigned - 2.3.1.286 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26854234&form=6&db=m ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA. unassigned - 2.3.1.286 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18215521&form=6&db=m AsSIRTing the DNA damage response. unassigned - 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20606253&form=6&db=m SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice. unassigned - 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23238746&form=6&db=m SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells. unassigned - 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27045039&form=6&db=m Cholesterol Metabolism: A Review of How Ageing Disrupts the Biological Mechanisms Responsible for its Regulation. unassigned - 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28467723&form=6&db=m Does Metformin Protect Diabetic Patients from Oxidative Stress and Leukocyte-Endothelium Interactions? unassigned - 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33614337&form=6&db=m A Paradigm Shift in the Management of Atherosclerosis: Protective Role of Sirtuins in Atherosclerosis. unassigned - 2.3.1.286 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18687325&form=6&db=m sirt1-null mice develop an autoimmune-like condition. unassigned - 2.3.1.286 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33330467&form=6&db=m The Versatility of Sirtuin-1 in Endocrinology and Immunology. unassigned - 2.3.1.286 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29129747&form=6&db=m Mitochondrial SIRT3 and neurodegenerative brain disorders. unassigned - 2.3.1.286 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25281876&form=6&db=m Alpha-lipoic acid upregulates SIRT1-dependent PGC-1? expression and protects mouse brain against focal ischemia. unassigned - 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26373435&form=6&db=m Radiation-Induced Alteration of the Brain Proteome: Understanding the Role of the Sirtuin 2 Deacetylase in a Murine Model. unassigned - 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32876840&form=6&db=m Fucoxanthin Mitigates Subarachnoid Hemorrhage-Induced Oxidative Damage via Sirtuin 1-Dependent Pathway. unassigned - 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33081556&form=6&db=m Honokiol ameliorates radiation-induced brain injury via the activation of SIRT3. unassigned - 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21565925&form=6&db=m Recent progress in carcinogenesis, progression and therapy of breast cancer: the 20th Hiroshima Cancer Seminar--the 4th Three Universities' Consortium International Symposium, October 2010: 31 October 2010, International Conference Center Hiroshima. unassigned - 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23032974&form=6&db=m Targeted expression of miR-34a using the T-VISA system suppresses breast cancer cell growth and invasion. unassigned - 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23365133&form=6&db=m Defining the Role of Histone Deacetylases in the Inhibition of Mammary Carcinogenesis by Dietary Energy Restriction (DER): Effects of Suberoylanilide Hydroxamic Acid (SAHA) and DER in a Rat Model. unassigned - 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25128872&form=6&db=m Sirtuin 3 interacts with Lon protease and regulates its acetylation status. unassigned - 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26622943&form=6&db=m A novel MeCP2 acetylation site regulates interaction with ATRX and HDAC1. unassigned - 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28025657&form=6&db=m miR-200a controls hepatic stellate cell activation and fibrosis via SIRT1/Notch1 signal pathway. unassigned - 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29752474&form=6&db=m Checkpoint suppressor 1 suppresses transcriptional activity of ER? and breast cancer cell proliferation via deacetylase SIRT1. unassigned - 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30697969&form=6&db=m Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial-mesenchymal transition and modulating SIRT1/?-catenin signaling pathway in breast cancer. unassigned - 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31591441&form=6&db=m A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo. unassigned - 2.3.1.286 Bronchopulmonary Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31858575&form=6&db=m Budesonide and Poractant Alfa prevent bronchopulmonary dysplasia via triggering SIRT1 signaling pathway. unassigned - 2.3.1.286 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29407771&form=6&db=m Triptolide induces mitochondria-mediated apoptosis of Burkitt's lymphoma cell via deacetylation of GSK-3? by increased SIRT3 expression. unassigned - 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19680552&form=6&db=m CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. unassigned - 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20025641&form=6&db=m Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer. unassigned - 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20943487&form=6&db=m [Mechanism of regulating deacetylase SIRT1 expression and activity.]. unassigned - 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23886445&form=6&db=m Regulation of MnSOD Enzymatic Activity by Sirt3 Connects the Mitochondrial Acetylome Signaling Networks to Aging and Carcinogenesis. unassigned - 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23900402&form=6&db=m Discovery of a potent small molecule SIRT1/2 inhibitor with anticancer effects. unassigned - 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24064057&form=6&db=m Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer. unassigned - 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27613566&form=6&db=m hnRNP A1 antagonizes cellular senescence and senescence-associated secretory phenotype via regulation of SIRT1 mRNA stability. unassigned - 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28427145&form=6&db=m Uncoupling genotoxic stress responses from circadian control increases susceptibility to mammary carcinogenesis. unassigned - 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29207098&form=6&db=m FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain. unassigned - 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29286123&form=6&db=m [Retracted] FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain. unassigned - 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30755608&form=6&db=m Publisher Correction: Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis. unassigned - 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28717923&form=6&db=m MiRNA-200a induce cell apoptosis in renal cell carcinoma by directly targeting SIRT1. unassigned - 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31809227&form=6&db=m MiR-199a-5p represses the stemness of cutaneous squamous cell carcinoma stem cells by targeting Sirt1 and CD44ICD cleavage signaling. unassigned - 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22479397&form=6&db=m Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1? protein under hypoxic conditions. unassigned - 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29344126&form=6&db=m microRNA-34a overexpression inhibits cell migration and invasion via regulating SIRT1 in hepatocellular carcinoma. unassigned - 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30909652&form=6&db=m Engagement with tNOX (ENOX2) to Inhibit SIRT1 and Activate p53-Dependent and -Independent Apoptotic Pathways by Novel 4,11-Diaminoanthra[2,3-b]furan-5,10-diones in Hepatocellular Carcinoma Cells. unassigned - 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31807195&form=6&db=m Erratum: microRNA-34a overexpression inhibits cell migration and invasion via regulating SIRT1 in hepatocellular carcinoma. unassigned - 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32894639&form=6&db=m Modulation of antioxidant enzymes, SIRT1 and NF-?B by resveratrol and nicotinamide in alcohol-aflatoxin B1-induced hepatocellular carcinoma. unassigned - 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28292429&form=6&db=m Corrigendum to "SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth" [Biochem. Biophys. Res. Commun. 483 (2017) 880-884]. unassigned - 2.3.1.286 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28717923&form=6&db=m MiRNA-200a induce cell apoptosis in renal cell carcinoma by directly targeting SIRT1. unassigned - 2.3.1.286 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31809227&form=6&db=m MiR-199a-5p represses the stemness of cutaneous squamous cell carcinoma stem cells by targeting Sirt1 and CD44ICD cleavage signaling. unassigned - 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18192211&form=6&db=m Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the {alpha}-myosin heavy chain expression. unassigned - 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25524917&form=6&db=m Lowering Body Weight in Obese Mice With Diastolic Heart Failure Improves Cardiac Insulin Sensitivity and Function: Implications for the Obesity Paradox. unassigned - 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32135248&form=6&db=m A machine learning-driven study indicates emodin improves cardiac hypertrophy by modulation of mitochondrial SIRT3 signaling. unassigned - 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32882218&form=6&db=m CSN6 aggravates Ang II-induced cardiomyocyte hypertrophy via inhibiting SIRT2. unassigned - 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33324687&form=6&db=m Hispidulin Attenuates Cardiac Hypertrophy by Improving Mitochondrial Dysfunction. unassigned - 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33611744&form=6&db=m PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2. unassigned - 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27889531&form=6&db=m SIRT1 protects cardiac cells against apoptosis induced by zearalenone or its metabolites ?- and ?-zearalenol through an autophagy-dependent pathway. unassigned - 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28760703&form=6&db=m Berberine-induced Cardioprotection and Sirt3 Modulation in Doxorubicin-treated H9c2 Cardiomyoblasts. unassigned - 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29304479&form=6&db=m MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2. unassigned - 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31858651&form=6&db=m Calycosin ameliorates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1-NOD-like receptor protein 3 pathway. unassigned - 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33469262&form=6&db=m Roflumilast Attenuates Doxorubicin-Induced Cardiotoxicity by Targeting Inflammation and Cellular Senescence in Cardiomyocytes Mediated by SIRT1. unassigned - 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34028595&form=6&db=m Sirtuins as molecular targets, mediators, and protective agents in metal-induced toxicity. unassigned - 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21102633&form=6&db=m SIRT1: recent lessons from mouse models. unassigned - 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26138757&form=6&db=m SIRT3 regulates progression and development of diseases of aging. unassigned - 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28804544&form=6&db=m SIRT3 attenuates AngII-induced cardiac fibrosis by inhibiting myofibroblasts transdifferentiation via STAT3-NFATc2 pathway. unassigned - 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30393491&form=6&db=m Association of common polymorphisms in the VEGFA and SIRT1 genes with type 2 diabetes-related traits in Mexicans. unassigned - 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30864731&form=6&db=m Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress. unassigned - 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32425973&form=6&db=m Post-translational Modification Crosstalk and Hotspots in Sirtuin Interactors Implicated in Cardiovascular Diseases. unassigned - 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32939234&form=6&db=m Stem cell-derived extracellular vesicles mitigate ageing-associated arterial stiffness and hypertension. unassigned - 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33485900&form=6&db=m NAD+ and cardiovascular diseases. unassigned - 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33802566&form=6&db=m Regulation of miRNAs by Natural Antioxidants in Cardiovascular Diseases: Focus on SIRT1 and eNOS. unassigned - 2.3.1.286 Chemical and Drug Induced Liver Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31354914&form=6&db=m The Beneficial Roles of SIRT1 in Drug-Induced Liver Injury. unassigned - 2.3.1.286 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27639250&form=6&db=m Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid fed mouse model of cholestasis. unassigned - 2.3.1.286 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25440052&form=6&db=m Linking DNA damage, NAD(+)/SIRT1, and aging. unassigned - 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18326939&form=6&db=m HDACs and HDAC inhibitors in colon cancer. unassigned - 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21067862&form=6&db=m Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells. unassigned - 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29552311&form=6&db=m MiR-29b reverses oxaliplatin-resistance in colorectal cancer by targeting SIRT1. unassigned - 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30864709&form=6&db=m Butyrate inhibits the proliferation and induces the apoptosis of colorectal cancer HCT116 cells via the deactivation of mTOR/S6K1 signaling mediated partly by SIRT1 downregulation. unassigned - 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33450304&form=6&db=m Regulation of SIRT2 by Wnt/?-catenin signaling pathway in colorectal cancer cells. unassigned - 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30684534&form=6&db=m Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease. unassigned - 2.3.1.286 Depression, Postpartum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34265417&form=6&db=m Ameliorative effect of SIRT1 in postpartum depression mediated by upregulation of the glucocorticoid receptor. unassigned - 2.3.1.286 Dermatitis, Phototoxic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30710171&form=6&db=m The photocytotoxicity effect of cationic sulfonated corrole towards lung cancer cells: in vitro and in vivo study. unassigned - 2.3.1.286 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27181414&form=6&db=m Diabetic complications within the context of aging: Nicotinamide adenine dinucleotide redox, insulin C-peptide, sirtuin 1-liver kinase B1-adenosine monophosphate-activated protein kinase positive feedback and forkhead box O3. unassigned - 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26337692&form=6&db=m Circulating SIRT1 Increases After Intragastric Balloon Fat Loss in Obese Patients. unassigned - 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34161185&form=6&db=m Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective. unassigned - 2.3.1.286 Diabetes Mellitus, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30381241&form=6&db=m Experimental diabetes mellitus exacerbates ischemia/reperfusion-induced myocardial injury by promoting mitochondrial fission: Role of down-regulation of myocardial Sirt1 and subsequent Akt/Drp1 interaction. unassigned - 2.3.1.286 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32564762&form=6&db=m Can Functionally Mature Islet ?-Cells Be Derived from Pluripotent Stem Cells? - A Step Towards Ready-To-Use ?-Cells in Type 1 Diabetes. unassigned - 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22761194&form=6&db=m The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes. unassigned - 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25563725&form=6&db=m SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes. unassigned - 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27101740&form=6&db=m Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6. unassigned - 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30367115&form=6&db=m The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 diabetes. unassigned - 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31799723&form=6&db=m Type 2 diabetes-associated polymorphisms correlate with SIRT1 and TGF-?1 gene expression. unassigned - 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32835596&form=6&db=m The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1? signalling pathway. unassigned - 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34161185&form=6&db=m Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective. unassigned - 2.3.1.286 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26629991&form=6&db=m Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway. unassigned - 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28883902&form=6&db=m SIRT1 Activation by Resveratrol Alleviates Cardiac Dysfunction via Mitochondrial Regulation in Diabetic Cardiomyopathy Mice. unassigned - 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28965951&form=6&db=m Polydatin ameliorates diabetic cardiomyopathy via Sirt3 activation. unassigned - 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30125566&form=6&db=m miR-133b and miR-199b knockdown attenuate TGF-?1-induced epithelial to mesenchymal transition and renal fibrosis by targeting SIRT1 in diabetic nephropathy. unassigned - 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30668374&form=6&db=m Salidroside stimulates the Sirt1/PGC-1? axis and ameliorates diabetic nephropathy in mice. unassigned - 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32660255&form=6&db=m Cdk5-Mediated Phosphorylation of Sirt1 Contributes to Podocyte Mitochondrial Dysfunction in Diabetic Nephropathy. unassigned - 2.3.1.286 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29296613&form=6&db=m mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy. unassigned - 2.3.1.286 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32683581&form=6&db=m SIRT1 Activation by Polydatin Alleviates Oxidative Damage and Elevates Mitochondrial Biogenesis in Experimental Diabetic Neuropathy. unassigned - 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25201925&form=6&db=m Sirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy. unassigned - 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28774737&form=6&db=m The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor. unassigned - 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34498499&form=6&db=m LncRNA XIST restrains the activation of Müller cells and inflammation in diabetic retinopathy via stabilizing SIRT1. unassigned - 2.3.1.286 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26426055&form=6&db=m Intracellular Mono-ADP-Ribosylation in Signaling and Disease. unassigned - 2.3.1.286 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25031331&form=6&db=m Carob pod insoluble fiber exerts anti-atherosclerotic effects in rabbits through sirtuin-1 and peroxisome proliferator-activated receptor-? coactivator-1?. unassigned - 2.3.1.286 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29274033&form=6&db=m Supplementation with an insoluble fiber obtained from carob pod (Ceratonia siliqua L.) rich in polyphenols prevents dyslipidemia in rabbits through SIRT1/PGC-1? pathway. unassigned - 2.3.1.286 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25725784&form=6&db=m Overexpression of SIRT1 Induced by Resveratrol and Inhibitor of miR-204 Suppresses Activation and Proliferation of Microglia. unassigned - 2.3.1.286 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32401642&form=6&db=m Autophagy in the physiological endometrium and cancer. unassigned - 2.3.1.286 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34161185&form=6&db=m Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective. unassigned - 2.3.1.286 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32401642&form=6&db=m Autophagy in the physiological endometrium and cancer. unassigned - 2.3.1.286 Enterocolitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32950974&form=6&db=m Lipopolysaccharide upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1). unassigned - 2.3.1.286 Enterocolitis, Necrotizing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32657204&form=6&db=m SIRT1 relieves Necrotizing Enterocolitis through inactivation of Hypoxia-inducible factor (HIF)-1a. unassigned - 2.3.1.286 Eye Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31119774&form=6&db=m Prediction of potential drugs and targets based on meibomian gland dysfunction module classification to guide individualized treatment. unassigned - 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21102633&form=6&db=m SIRT1: recent lessons from mouse models. unassigned - 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21708146&form=6&db=m Betaine feeding prevents the blood alcohol cycle in rats fed alcohol continuously for 1month using the rat intragastric tube feeding model. unassigned - 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23867312&form=6&db=m Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation. unassigned - 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25916635&form=6&db=m Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway. unassigned - 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26337692&form=6&db=m Circulating SIRT1 Increases After Intragastric Balloon Fat Loss in Obese Patients. unassigned - 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26525891&form=6&db=m Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease. unassigned - 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27107702&form=6&db=m MicroRNA-421 induces hepatic mitochondrial dysfunction in non-alcoholic fatty liver disease mice by inhibiting sirtuin 3. unassigned - 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27246221&form=6&db=m Molecular, Cellular, and Physiological Characterization of Sirtuin 7 (SIRT7). unassigned - 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28923496&form=6&db=m Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced hepatic steatosis in mice. unassigned - 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31390551&form=6&db=m Generation of Human Fatty Livers Using Custom-Engineered Induced Pluripotent Stem Cells with Modifiable SIRT1 Metabolism. unassigned - 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33548473&form=6&db=m Tomatidine ameliorates obesity-induced nonalcoholic fatty liver disease in mice. unassigned - 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33578292&form=6&db=m Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1. unassigned - 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34436591&form=6&db=m Sirtuin 1 is involved in oleic acid-induced calf hepatocyte steatosis via alterations in lipid metabolism-related proteins. unassigned - 2.3.1.286 Fatty Liver, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18755807&form=6&db=m Resveratrol alleviates alcoholic fatty liver in mice. unassigned - 2.3.1.286 Fatty Liver, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22308024&form=6&db=m MiR-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1. unassigned - 2.3.1.286 Fatty Liver, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33971886&form=6&db=m Combined intake of blueberry juice and probiotics ameliorate mitochondrial dysfunction by activating SIRT1 in alcoholic fatty liver disease. unassigned - 2.3.1.286 Fetal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655546&form=6&db=m Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy. unassigned - 2.3.1.286 Fetal Growth Retardation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28292463&form=6&db=m Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction. unassigned - 2.3.1.286 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29207098&form=6&db=m FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain. unassigned - 2.3.1.286 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29286123&form=6&db=m [Retracted] FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain. unassigned - 2.3.1.286 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33675893&form=6&db=m Cyproheptadine causes apoptosis and decreases inflammation by disrupting thiol/disulfide balance and enhancing the levels of SIRT1 in C6 glioblastoma cells. unassigned - 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17457050&form=6&db=m The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation. unassigned - 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24631135&form=6&db=m Cinnamon polyphenols attenuate the hydrogen peroxide-induced down regulation of S100? secretion by regulating sirtuin 1 in C6 rat glioma cells. unassigned - 2.3.1.286 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33027895&form=6&db=m Parental SIRT1 Overexpression Attenuate Metabolic Disorders Due to Maternal High-Fat Feeding. unassigned - 2.3.1.286 Glycosuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25563725&form=6&db=m SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes. unassigned - 2.3.1.286 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26472659&form=6&db=m Localization of sirtuins (SIRT1-7) in the aged mouse inner ear. unassigned - 2.3.1.286 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34530105&form=6&db=m Environmental enrichment modulates silent information regulator 1 (SIRT1) activity to attenuate central presbycusis in a rat model of normal aging. unassigned - 2.3.1.286 Hearing Loss, Noise-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25470550&form=6&db=m Activation of SIRT3 by the NAD? precursor nicotinamide riboside protects from noise-induced hearing loss. unassigned - 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26707577&form=6&db=m Nicotinamide adenine dinucleotide homeostasis and signalling in heart disease: Pathophysiological implications and therapeutic potential. unassigned - 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32572936&form=6&db=m Kallistatin alleviates heart failure in rats by inhibiting myocardial inflammation and apoptosis via regulating sirt1. unassigned - 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34363948&form=6&db=m Mitochondrial proteins in heart failure: The role of deacetylation by SIRT3. unassigned - 2.3.1.286 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33068864&form=6&db=m Hesperetin, a SIRT1 activator, inhibits hepatic inflammation via AMPK/CREB pathway. unassigned - 2.3.1.286 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24297698&form=6&db=m The metabolic sensors FXR?, PGC-1?, and SIRT1 cooperatively regulate hepatitis B virus transcription. unassigned - 2.3.1.286 Hepatoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29956732&form=6&db=m Single-walled carbon nanohorn aggregates promotes mitochondrial dysfunction-induced apoptosis in hepatoblastoma cells by targeting SIRT3. unassigned - 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22227661&form=6&db=m Finding a sirtuin truth in Huntington's disease. unassigned - 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23342163&form=6&db=m High glucose induced alteration of SIRTs in endothelial cells causes rapid aging in a p300 and FOXO regulated pathway. unassigned - 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23358244&form=6&db=m Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation. unassigned - 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32380741&form=6&db=m Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication-Potential Implication of Sirtuins. unassigned - 2.3.1.286 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34370653&form=6&db=m Antihyperlipidemic and Hepatoprotective Properties of Vitamin B6 Supplementation in Rats with High-Fat Diet-Induced Hyperlipidemia. unassigned - 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32078456&form=6&db=m Hypertension and Mitochondrial Oxidative Stress Revisited: Sirtuin 3, the Improved "Antioxidant". unassigned - 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33012204&form=6&db=m Mitochondrial Isolevuglandins Contribute to Vascular Oxidative Stress and Mitochondria-Targeted Scavenger of Isolevuglandins Reduces Mitochondrial Dysfunction and Hypertension. unassigned - 2.3.1.286 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30230565&form=6&db=m Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-?1/Smad2 and nuclear factor-?B signaling pathways in human fetal lung fibroblasts. unassigned - 2.3.1.286 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31569558&form=6&db=m N-Palmitoylethanolamide-Oxazoline Protects against Middle Cerebral Artery Occlusion Injury in Diabetic Rats by Regulating the SIRT1 Pathway. unassigned - 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25098820&form=6&db=m Plant defence suppression is mediated by a fungal sirtuin during rice infection by Magnaporthe oryzae. unassigned - 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28429797&form=6&db=m Sirtuins in the phylum Basidiomycota: A role in virulence in Cryptococcus neoformans. unassigned - 2.3.1.286 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32497285&form=6&db=m Absence of Sirtuin 1 impairs the testicular development in cattleyak by inactivating SF-1. unassigned - 2.3.1.286 Infertility, Male http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18987333&form=6&db=m The histone deacetylase SIRT1 controls male fertility in mice through regulation of hypothalamic-pituitary gonadotropin signaling. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18393104&form=6&db=m Sirtuins: novel targets for metabolic disease. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20190133&form=6&db=m SIRT1 takes a backseat to AMPK in the regulation of insulin sensitivity by resveratrol. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20375183&form=6&db=m Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via Agouti-Related Peptide. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21113404&form=6&db=m Peroxisome Proliferator-Activated Receptor -?/?, -? Agonists and Resveratrol Modulate Hypoxia Induced Changes in Nuclear Receptor Activators of Muscle Oxidative Metabolism. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21149440&form=6&db=m FoxO1 mediates an autofeedback loop regulating SIRT1 expression. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22908267&form=6&db=m Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24093677&form=6&db=m Resveratrol Improves Adipose Insulin Signaling and Reduces the Inflammatory Response in Adipose Tissue of Rhesus Monkeys on High-Fat, High-Sugar Diet. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25612477&form=6&db=m Modulation of SIRT1-Foxo1 Signaling axis by Resveratrol: Implications in Skeletal Muscle Aging and Insulin Resistance. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26574954&form=6&db=m Obesity Is Associated With Low NAD(+)/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28678523&form=6&db=m Nutritional biomarkers: Current view and future perspectives. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30559718&form=6&db=m Distinctive Roles of Sirtuins on Diabetes, Protective or Detrimental? unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30721374&form=6&db=m Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes (L-serine activates SIRT1 in C2C12 myotubes). unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31111276&form=6&db=m Correction to: Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31125554&form=6&db=m TRB3 stimulates SIRT1 degradation and induces insulin resistance by lipotoxicity via COP1. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32380741&form=6&db=m Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication-Potential Implication of Sirtuins. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32777783&form=6&db=m Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32848804&form=6&db=m SIRT1 Activation by Natural Phytochemicals: An Overview. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33004402&form=6&db=m Metabolic and energetic benefits of microRNA-22 inhibition. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33009367&form=6&db=m SIRT1 deacetylates mitochondrial trifunctional enzyme ? subunit to inhibit ubiquitylation and decrease insulin resistance. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33251210&form=6&db=m New Amphiphilic Squalene Derivative Improves Metabolism of Adipocytes Differentiated From Diabetic Adipose-Derived Stem Cells and Prevents Excessive Lipogenesis. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33271386&form=6&db=m Resistin mitigates stemness and metabolic profile of human adipose-derived mesenchymal stem cells via insulin resistance. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33907035&form=6&db=m Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34161185&form=6&db=m Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective. unassigned - 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34252390&form=6&db=m Involvement of nitric oxide synthase/nitric oxide pathway in the regulation of SIRT1-AMPK crosstalk in podocytes: Impact on glucose uptake. unassigned - 2.3.1.286 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22584570&form=6&db=m Neurodegeneration-associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells. unassigned - 2.3.1.286 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26752489&form=6&db=m SIRT1 Inhibits the Catabolic Effect of IL-1? Through TLR2/SIRT1/NF-?B Pathway in Human Degenerative Nucleus Pulposus Cells. unassigned - 2.3.1.286 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30216853&form=6&db=m Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration. unassigned - 2.3.1.286 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32967533&form=6&db=m Mitophagy in degenerative joint diseases. unassigned - 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33027757&form=6&db=m Liraglutide protects against high-fat diet-induced kidney injury by ameliorating apoptosis. unassigned - 2.3.1.286 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31032918&form=6&db=m Critical role of mitochondrial dysfunction and impaired mitophagy in diabetic nephropathy. unassigned - 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31476975&form=6&db=m The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress. unassigned - 2.3.1.286 Leukemia-Lymphoma, Adult T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26398583&form=6&db=m SIRT1 downregulation enhances chemosensitivity and survival of adult T-cell leukemia-lymphoma cells by reducing DNA double-strand repair. unassigned - 2.3.1.286 Lipid Metabolism Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28817690&form=6&db=m Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat diet-fed rats. unassigned - 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30502394&form=6&db=m ?-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis. unassigned - 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22308024&form=6&db=m MiR-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1. unassigned - 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25916635&form=6&db=m Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway. unassigned - 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26525891&form=6&db=m Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease. unassigned - 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27107702&form=6&db=m MicroRNA-421 induces hepatic mitochondrial dysfunction in non-alcoholic fatty liver disease mice by inhibiting sirtuin 3. unassigned - 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27246221&form=6&db=m Molecular, Cellular, and Physiological Characterization of Sirtuin 7 (SIRT7). unassigned - 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28923496&form=6&db=m Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced hepatic steatosis in mice. unassigned - 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32365537&form=6&db=m EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats. unassigned - 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33578292&form=6&db=m Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1. unassigned - 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33971886&form=6&db=m Combined intake of blueberry juice and probiotics ameliorate mitochondrial dysfunction by activating SIRT1 in alcoholic fatty liver disease. unassigned - 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34161185&form=6&db=m Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective. unassigned - 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27774669&form=6&db=m Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis. unassigned - 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28292429&form=6&db=m Corrigendum to "SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth" [Biochem. Biophys. Res. Commun. 483 (2017) 880-884]. unassigned - 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31410153&form=6&db=m miR-448 promotes progression of non-small-cell lung cancer via targeting SIRT1. unassigned - 2.3.1.286 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28336124&form=6&db=m Ultraviolet B inhibition of DNMT1 activity via AhR activation dependent SIRT1 suppression in CD4+ T cells from systemic lupus erythematosus patients. unassigned - 2.3.1.286 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28197079&form=6&db=m SIRT3 in Neural Stem Cells Attenuates Microglia Activation-Induced Oxidative Stress Injury Through Mitochondrial Pathway. unassigned - 2.3.1.286 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33204711&form=6&db=m Mir-141-3p Regulates Apoptosis and Mitochondrial Membrane Potential via Targeting Sirtuin1 in a 1-Methyl-4-Phenylpyridinium in vitro Model of Parkinson's Disease. unassigned - 2.3.1.286 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33937961&form=6&db=m Expression of miR-34a and miR-15b during the progression of cervical cancer in a murine model expressing the HPV16 E7 oncoprotein. unassigned - 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23299244&form=6&db=m SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain. unassigned - 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28693188&form=6&db=m Consecutive stimulation of HBsAg promotes the viability of the human B lymphoblastoid cell line IM-9 through regulating the SIRT1-NF-?B pathway. unassigned - 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32905193&form=6&db=m Alogliptin: a novel approach against cyclophosphamide-induced hepatic injury via modulating SIRT1/FoxO1 pathway. unassigned - 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33204711&form=6&db=m Mir-141-3p Regulates Apoptosis and Mitochondrial Membrane Potential via Targeting Sirtuin1 in a 1-Methyl-4-Phenylpyridinium in vitro Model of Parkinson's Disease. unassigned - 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33937961&form=6&db=m Expression of miR-34a and miR-15b during the progression of cervical cancer in a murine model expressing the HPV16 E7 oncoprotein. unassigned - 2.3.1.286 Machado-Joseph Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34416891&form=6&db=m Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo. unassigned - 2.3.1.286 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21890195&form=6&db=m Delivery of Oct4 and SirT1 with cationic polyurethanes-short branch PEI to aged retinal pigment epithelium. unassigned - 2.3.1.286 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30399423&form=6&db=m SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, LIPC rs10468017, rs493258 and LPL rs12678919 genotypes and haplotype evaluation in patients with age-related macular degeneration. unassigned - 2.3.1.286 Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26111566&form=6&db=m Catch-Up Growth: Basic Mechanisms. unassigned - 2.3.1.286 Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30305620&form=6&db=m SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression. unassigned - 2.3.1.286 Malocclusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20412791&form=6&db=m Disruption of Igfbp1 fails to rescue the phenotype of Sirt1-/- mice. unassigned - 2.3.1.286 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28706491&form=6&db=m Early-Life Exposure to Lead Induces Cognitive Impairment in Elder Mice Targeting SIRT1 Phosphorylation and Oxidative Alterations. unassigned - 2.3.1.286 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31280254&form=6&db=m Ketones improves Apolipoprotein E4-related memory deficiency via sirtuin 3. unassigned - 2.3.1.286 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33907035&form=6&db=m Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction. unassigned - 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17099246&form=6&db=m SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. unassigned - 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24347837&form=6&db=m E. coli endotoxin modulates the expression of Sirtuin proteins in PBMC in humans. unassigned - 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25871950&form=6&db=m Lipopolysaccharides-Induced Inflammatory Response in White Blood Cells Is Associated with Alterations in Senescence Mediators: Modulation by Metformin. unassigned - 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31587111&form=6&db=m Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide. unassigned - 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22562958&form=6&db=m SIRT3 Weighs Heavily in the Metabolic Balance: A New Role for SIRT3 in Metabolic Syndrome. unassigned - 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24041461&form=6&db=m Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation. unassigned - 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24430182&form=6&db=m Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation. unassigned - 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26138757&form=6&db=m SIRT3 regulates progression and development of diseases of aging. unassigned - 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29017895&form=6&db=m Short-term fructose ingestion affects the brain independently from establishment of metabolic syndrome. unassigned - 2.3.1.286 Mitochondrial Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22834844&form=6&db=m Extranuclear localization of SIRT1 and PGC-1?: an insight into possible roles in diseases associated with mitochondrial dysfunction. unassigned - 2.3.1.286 Mitral Valve Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32350389&form=6&db=m Regulation of left atrial fibrosis induced by mitral regurgitation by SIRT1. unassigned - 2.3.1.286 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24064732&form=6&db=m Isoflavones Derived from Soy Beans Prevent MuRF1-Mediated Muscle Atrophy in C2C12 Myotubes through SIRT1 Activation. unassigned - 2.3.1.286 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29512306&form=6&db=m Preventing muscle wasting by osteoporosis drug alendronate in vitro and in myopathy models via sirtuin-3 down-regulation. unassigned - 2.3.1.286 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33935745&form=6&db=m The Treatment of Rhodiola Mimics Exercise to Resist High-Fat Diet-Induced Muscle Dysfunction via Sirtuin1-Dependent Mechanisms. unassigned - 2.3.1.286 Muscular Disorders, Atrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33233350&form=6&db=m PGC-1?-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging. unassigned - 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26762065&form=6&db=m [Cardioprotective Effect and Its Mechanism of Total Saponins of Panacis Majoris Rhizoma in Myocardial Infarction Rats]. unassigned - 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31486508&form=6&db=m MiR-34a promotes myocardial infarction in rats by inhibiting the activity of SIRT1. unassigned - 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32228121&form=6&db=m SIRT3 Transfection of Aged Human Bone Marrow-Derived Mesenchymal Stem Cells Improves Cell Therapy-Mediated Myocardial Repair. unassigned - 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33325044&form=6&db=m Hydrogen sulfide restores sevoflurane postconditioning mediated cardioprotection in diabetic rats: Role of SIRT1/Nrf2 signaling-modulated mitochondrial dysfunction and oxidative stress. unassigned - 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33594087&form=6&db=m The miRNA199a/SIRT1/P300/Yy1/sST2 signaling axis regulates adverse cardiac remodeling following MI. unassigned - 2.3.1.286 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32434515&form=6&db=m Rno-microRNA-30c-5p promotes myocardial ischemia reperfusion injury in rats through activating NF-?B pathway and targeting SIRT1. unassigned - 2.3.1.286 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34080028&form=6&db=m Critical role of SIRT1 upregulation on the protective effect of lncRNA ANRIL against hypoxia/reoxygenation injury in H9c2 cardiomyocytes. unassigned - 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21565925&form=6&db=m Recent progress in carcinogenesis, progression and therapy of breast cancer: the 20th Hiroshima Cancer Seminar--the 4th Three Universities' Consortium International Symposium, October 2010: 31 October 2010, International Conference Center Hiroshima. unassigned - 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29421536&form=6&db=m SIRT3 inhibits prostate cancer metastasis through regulation of FOXO3A by suppressing Wnt/?-catenin pathway. unassigned - 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31131636&form=6&db=m Upregulation of long non-coding RNA OGFRP1 facilitates endometrial cancer by regulating miR-124-3p/SIRT1 axis and by activating PI3K/AKT/GSK-3? pathway. unassigned - 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33489803&form=6&db=m Hsa_circ_0006571 promotes spinal metastasis through sponging microRNA-138 to regulate sirtuin 1 expression in lung adenocarcinoma. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12220851&form=6&db=m Human Sir2 and the 'silencing' of p53 activity. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14980222&form=6&db=m Mammalian SIRT1 represses forkhead transcription factors. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18704159&form=6&db=m Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18723829&form=6&db=m SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18805010&form=6&db=m The ups and downs of SIRT1. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19680552&form=6&db=m CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19680556&form=6&db=m Genetic variation in healthy oldest-old. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19879981&form=6&db=m SIRT1-dependent regulation of chromatin and transcription: Linking NAD(+) metabolism and signaling to the control of cellular functions. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20025641&form=6&db=m Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21102633&form=6&db=m SIRT1: recent lessons from mouse models. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21397853&form=6&db=m SIRT3 Controls Cancer Metabolic Reprogramming by Regulating ROS and HIF. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21497775&form=6&db=m Sirt1's systemic protective roles and its promise as a target in antiaging medicine. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21566644&form=6&db=m Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21807603&form=6&db=m The human sirtuin family: Evolutionary divergences and functions. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21841822&form=6&db=m Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22124156&form=6&db=m A deacetylase-deficient SIRT1 variant opposes full-length SIRT1 in regulating tumor suppressor p53 and governs expression of cancer-related genes. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22337808&form=6&db=m c-MYC and SIRT1 locked in a vicious cycle. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22378745&form=6&db=m A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose exposed HepG2 cells. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22479397&form=6&db=m Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1? protein under hypoxic conditions. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22536923&form=6&db=m Epigenetic mechanisms in anti-cancer actions of bioactive food components - the implications in cancer prevention. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23230084&form=6&db=m Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23311358&form=6&db=m The 2.5 Ċ crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23468428&form=6&db=m The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23519122&form=6&db=m Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23603572&form=6&db=m PPAR? agonist fenofibrate attenuates TNF-?-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24064057&form=6&db=m Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24337047&form=6&db=m Selenium?enriched exopolysaccharides produced by Enterobacter cloacae Z0206 alleviate adipose inflammation in diabetic KKAy mice through the AMPK/SirT1 pathway. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24347837&form=6&db=m E. coli endotoxin modulates the expression of Sirtuin proteins in PBMC in humans. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24471483&form=6&db=m Calorie restriction upregulated sirtuin 1 by attenuating its ubiquitin degradation in cancer cells. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24536059&form=6&db=m Molecular Pathways: Emerging Roles of Mammalian Sirtuin SIRT7 in Cancer. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24666314&form=6&db=m Effects of inhalational anaesthetics in experimental allergic asthma. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25871950&form=6&db=m Lipopolysaccharides-Induced Inflammatory Response in White Blood Cells Is Associated with Alterations in Senescence Mediators: Modulation by Metformin. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26138757&form=6&db=m SIRT3 regulates progression and development of diseases of aging. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26696402&form=6&db=m Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28162896&form=6&db=m Haploinsufficiency of SIRT1 Enhances Glutamine Metabolism and Promotes Cancer Development. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28465145&form=6&db=m Energy sensing pathways: Bridging type 2 diabetes and colorectal cancer? unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28754771&form=6&db=m Correction for Shah et al., "A Deacetylase-Deficient SIRT1 Variant Opposes Full-Length SIRT1 in Regulating Tumor Suppressor p53 and Governs Expression of Cancer-Related Genes". unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28929578&form=6&db=m Horizontal transfer of miR-23a from hypoxic tumor cell colonies can induce angiogenesis. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29367758&form=6&db=m The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29429051&form=6&db=m Cilostazol Mediated Nurr1 and Autophagy Enhancement: Neuroprotective Activity in Rat Rotenone PD Model. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29920283&form=6&db=m Rutin, a quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up-regulation of antioxidants and SIRT1. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30451820&form=6&db=m Long non-coding RNA H19 confers 5-Fu resistance in colorectal cancer by promoting SIRT1-mediated autophagy. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30683653&form=6&db=m Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30901181&form=6&db=m [Sirtuins and their role in metabolism regulation]. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30905812&form=6&db=m UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31020545&form=6&db=m Camptothecin activates SIRT1 to promote lipid catabolism through AMPK/FoxO1/ATGL pathway in C2C12 myogenic cells. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31082419&form=6&db=m JNK activation-mediated nuclear SIRT1 protein suppression contributes to silica nanoparticle-induced pulmonary damage via p53 acetylation and cytoplasmic localisation. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31131636&form=6&db=m Upregulation of long non-coding RNA OGFRP1 facilitates endometrial cancer by regulating miR-124-3p/SIRT1 axis and by activating PI3K/AKT/GSK-3? pathway. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31167142&form=6&db=m Yeast Sirtuin Family Members Maintain Transcription Homeostasis to Ensure Genome Stability. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31262199&form=6&db=m Thymoquinone ameliorates obesity-induced metabolic dysfunction, improves reproductive efficiency exhibiting a dose-organ relationship. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31366866&form=6&db=m The Function of PPAR?/AMPK/SIRT-1 Pathway in Inflammatory Response of Human Articular Chondrocytes Stimulated by Advanced Glycation End Products. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31932306&form=6&db=m Sirtuin 1 reduces hyaluronan synthase 2 expression by inhibiting nuclear translocation of NF-?B and expression of the long-noncoding RNA HAS2-AS1. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31977642&form=6&db=m High-Intensity Training and Saffron: Effects on Breast Cancer-related Gene Expression. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32072679&form=6&db=m Exendin-4 exhibits a tumour suppressor effect in SKOVR-3 and OVACR-3 ovarian cancer cells lines by the activation of SIRT1 and inhibition of NF-?B. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32100506&form=6&db=m [Effect of electroacupuncture on SIRT1/NF-?B signaling pathway in adipose tissue of obese rats]. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32286137&form=6&db=m Metformin activates AMPK/SIRT1/NF-?B pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32401642&form=6&db=m Autophagy in the physiological endometrium and cancer. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32967533&form=6&db=m Mitophagy in degenerative joint diseases. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33204711&form=6&db=m Mir-141-3p Regulates Apoptosis and Mitochondrial Membrane Potential via Targeting Sirtuin1 in a 1-Methyl-4-Phenylpyridinium in vitro Model of Parkinson's Disease. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33438557&form=6&db=m Discovery of Potent Natural-Product-Derived SIRT2 Inhibitors Using Structure-Based Exploration of SIRT2 Pharmacophoric Space Coupled With QSAR Analyses. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33492448&form=6&db=m miR-34a induces immunosuppression in colorectal carcinoma through modulating a SIRT1/NF-?B/B7-H3/TNF-? axis. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33608631&form=6&db=m Quercetin 3,5,7,3',4'-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1. unassigned - 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34100500&form=6&db=m Docosahexaenoic acid-enriched phospholipids and eicosapentaenoic acid-enriched phospholipids inhibit tumor necrosis factor-alpha-induced lipolysis in 3T3-L1 adipocytes by activating sirtuin 1 pathways. unassigned - 2.3.1.286 Nephrocalcinosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33867828&form=6&db=m Theaflavin protects against oxalate calcium-induced kidney oxidative stress injury via upregulation of SIRT1. unassigned - 2.3.1.286 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34506725&form=6&db=m Oligodendrocytes enhance axonal energy metabolism by deacetylation of mitochondrial proteins through transcellular delivery of SIRT2. unassigned - 2.3.1.286 Neural Tube Defects http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25131500&form=6&db=m Sirtuin inhibitor Ex-527 causes neural tube defects, ventral edema formations, and gastrointestinal malformations in Xenopus laevis embryos. unassigned - 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31296380&form=6&db=m Spinal miR-34a regulates inflammatory pain by targeting SIRT1 in complete Freund's adjuvant mice. unassigned - 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33762927&form=6&db=m Combination of Botulinum Toxin and minocycline Ameliorates Neuropathic Pain Through Antioxidant Stress and Anti-Inflammation via Promoting SIRT1 Pathway. unassigned - 2.3.1.286 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19558452&form=6&db=m The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide. unassigned - 2.3.1.286 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26915812&form=6&db=m Treatment with the neurotoxic A? (25-35) peptide modulates the expression of neuroprotective factors Pin1, Sirtuin 1, and brain-derived neurotrophic factor in SH-SY5Y human neuroblastoma cells. unassigned - 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25331946&form=6&db=m JAZ (Znf346), a SIRT1-interacting protein, protects neurons by stimulating p21 (WAF/CIP1) protein expression. unassigned - 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26138757&form=6&db=m SIRT3 regulates progression and development of diseases of aging. unassigned - 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29514133&form=6&db=m SIRT2 in age-related neurodegenerative disorders. unassigned - 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30889315&form=6&db=m Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure. unassigned - 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30973934&form=6&db=m Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1. unassigned - 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32447338&form=6&db=m Inhibition of the Peroxisome Proliferator-Activated Receptor gamma Coactivator 1-alpha (PGC-1?)/Sirtuin 3 (SIRT3) Pathway Aggravates Oxidative Stress After Experimental Subarachnoid Hemorrhage. unassigned - 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32865663&form=6&db=m Antioxidant Modulation of mTOR and Sirtuin Pathways in Age-Related Neurodegenerative Diseases. unassigned - 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29508282&form=6&db=m Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside. unassigned - 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31472247&form=6&db=m Berberine enhances survival and axonal regeneration of motoneurons following spinal root avulsion and re-implantation in rats. unassigned - 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32987101&form=6&db=m Treadmill exercise mitigates neuroinflammation and increases BDNF via activation of SIRT1 signaling in a mouse model of T2DM. unassigned - 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33411248&form=6&db=m Increasing Nrf2 Activity as a Treatment Approach in Neuropsychiatry. unassigned - 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34506597&form=6&db=m Saffron extract attenuates neuroinflammation in rmTBI mouse model by suppressing NLRP3 inflammasome activation via SIRT1. unassigned - 2.3.1.286 Nijmegen Breakage Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18215521&form=6&db=m AsSIRTing the DNA damage response. unassigned - 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22827449&form=6&db=m Cardiovascular disease is associated with high-fat-diet-induced liver damage and up-regulation of the hepatic expression of hypoxia-inducible factor 1? in a rat model. unassigned - 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25916635&form=6&db=m Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway. unassigned - 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26404765&form=6&db=m Eliciting the mitochondrial unfolded protein response via NAD(+) repletion reverses fatty liver disease. unassigned - 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26525891&form=6&db=m Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease. unassigned - 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27107702&form=6&db=m MicroRNA-421 induces hepatic mitochondrial dysfunction in non-alcoholic fatty liver disease mice by inhibiting sirtuin 3. unassigned - 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28042486&form=6&db=m A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice. unassigned - 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28536120&form=6&db=m Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up-regulation of Bach1, an Nrf2 repressor. unassigned - 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28923496&form=6&db=m Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced hepatic steatosis in mice. unassigned - 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31311301&form=6&db=m Long noncoding RNA FLRL2 alleviated nonalcoholic fatty liver disease through Arntl-Sirt1 pathway. unassigned - 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32365537&form=6&db=m EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats. unassigned - 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33234364&form=6&db=m Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe-/-mice: role of SIRT1. unassigned - 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33578292&form=6&db=m Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1. unassigned - 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33580500&form=6&db=m Major royal jelly proteins prevents NAFLD by improving mitochondrial function and lipid accumulation through activating the AMPK / SIRT3 pathway in vitro. unassigned - 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34161185&form=6&db=m Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17099246&form=6&db=m SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18829956&form=6&db=m Brain SIRT1: anatomical distribution and regulation by energy availability. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20548306&form=6&db=m Spontaneous caloric restriction associated with increased leptin levels in obesity-resistant alphaMUPA mice. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21738790&form=6&db=m Overexpression of SIRT1 in mouse forebrain impairs lipid/glucose metabolism and motor function. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23374890&form=6&db=m Obesity and kidney disease: potential mechanisms. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23990359&form=6&db=m PPAR? and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25182532&form=6&db=m MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25404345&form=6&db=m Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26337692&form=6&db=m Circulating SIRT1 Increases After Intragastric Balloon Fat Loss in Obese Patients. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26655722&form=6&db=m SIRT1 Limits Adipocyte Hyperplasia through c-Myc Inhibition. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27125385&form=6&db=m Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27480132&form=6&db=m SIRT1 and SIRT7 expression in adipose tissues of obese and normal-weight individuals is regulated by microRNAs but not by methylation status. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28249157&form=6&db=m Non-enzymatic N-acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S-acetylated Thiol Intermediate Sensitive to Glyoxalase II. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29042127&form=6&db=m Pinitol alleviates systemic inflammatory cytokines in human obesity by a mechanism involving unfolded protein response and sirtuin 1. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29786646&form=6&db=m Metabolic Reprogramming by 3-Iodothyronamine (T1AM): A New Perspective to Reverse Obesity through Co-Regulation of Sirtuin 4 and 6 Expression. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30178808&form=6&db=m Anti-obesity effects of Spirulina maxima in high fat diet induced obese rats via the activation of AMPK pathway and SIRT1. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30425749&form=6&db=m Electroacupuncture: A Feasible Sirt1 Promoter Which Modulates Metainflammation in Diet-Induced Obesity Rats. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30525192&form=6&db=m Breaking the intergenerational cycle of obesity with SIRT1. unassigned - 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32380741&form=6&db=m Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication-Potential Implication of Sirtuins. unassigned - 2.3.1.286 Obesity, Maternal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33027895&form=6&db=m Parental SIRT1 Overexpression Attenuate Metabolic Disorders Due to Maternal High-Fat Feeding. unassigned - 2.3.1.286 Obesity, Maternal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33185172&form=6&db=m Dyslipidemia, insulin resistance, and impairment of placental metabolism in the offspring of obese mothers. unassigned - 2.3.1.286 Obesity, Morbid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23928404&form=6&db=m Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity. unassigned - 2.3.1.286 Obesity, Morbid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24675148&form=6&db=m The FTO gene polymorphism (rs9939609) is associated with metabolic syndrome in morbidly obese subjects from southern Italy. unassigned - 2.3.1.286 Optic Neuritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31199170&form=6&db=m Does CETP rs5882, rs708272, SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, VEGFA rs833068, IL6 rs1800795 polymorphisms play a role in optic neuritis development? unassigned - 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28389425&form=6&db=m LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes. unassigned - 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32967533&form=6&db=m Mitophagy in degenerative joint diseases. unassigned - 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24949665&form=6&db=m The Sirtuin1 activator SRT3025 down-regulates sclerostin and rescues ovariectomy-induced bone loss and biomechanical deterioration in female mice. unassigned - 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31634777&form=6&db=m Ferulic acid, a natural polyphenol, protects against osteoporosis by activating SIRT1 and NF-?B in neonatal rats with glucocorticoid-induced osteoporosis. unassigned - 2.3.1.286 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34089817&form=6&db=m Modulation of NAD+ biosynthesis activates SIRT1 and resists cisplatin-induced ototoxicity. unassigned - 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30094960&form=6&db=m Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells. unassigned - 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32072679&form=6&db=m Exendin-4 exhibits a tumour suppressor effect in SKOVR-3 and OVACR-3 ovarian cancer cells lines by the activation of SIRT1 and inhibition of NF-?B. unassigned - 2.3.1.286 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22230810&form=6&db=m Three single nucleotide variants of the SIRT1 gene are associated with overweight in a Chinese population: a case control study. unassigned - 2.3.1.286 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30684534&form=6&db=m Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease. unassigned - 2.3.1.286 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33781829&form=6&db=m Activation of AMPK restored impaired autophagy and inhibited inflammation reaction by up-regulating SIRT1 in acute pancreatitis. unassigned - 2.3.1.286 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23644469&form=6&db=m Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain. unassigned - 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25991017&form=6&db=m Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells. unassigned - 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28656548&form=6&db=m Treadmill Exercise Attenuates ?-Synuclein Levels by Promoting Mitochondrial Function and Autophagy Possibly via SIRT1 in the Chronic MPTP/P-Induced Mouse Model of Parkinson's Disease. unassigned - 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28741160&form=6&db=m Erratum to: Treadmill Exercise Attenuates ?-Synuclein Levels by Promoting Mitochondrial Function and Autophagy Possibly via SIRT1 in the Chronic MPTP/P-Induced Mouse Model of Parkinson's Disease. unassigned - 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31244600&form=6&db=m Elevated Serum SIRT 2 May Differentiate Parkinson's Disease From Atypical Parkinsonian Syndromes. unassigned - 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32967533&form=6&db=m Mitophagy in degenerative joint diseases. unassigned - 2.3.1.286 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28673739&form=6&db=m Sirtuin 3 rescues neurons through the stabilisation of mitochondrial biogenetics in the virally-expressing mutant ?-synuclein rat model of parkinsonism. unassigned - 2.3.1.286 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23796896&form=6&db=m MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration. unassigned - 2.3.1.286 Peroxisomal Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31257461&form=6&db=m SIRT1 activation alleviates brain microvascular endothelial dysfunction in peroxisomal disorders. unassigned - 2.3.1.286 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27317260&form=6&db=m Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4(+) T Cells. unassigned - 2.3.1.286 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34161185&form=6&db=m Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective. unassigned - 2.3.1.286 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28292463&form=6&db=m Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction. unassigned - 2.3.1.286 Progeria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19680556&form=6&db=m Genetic variation in healthy oldest-old. unassigned - 2.3.1.286 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34411320&form=6&db=m SIRT3 affects mitochondrial metabolic reprogramming via the AMPK-PGC-1? axis in the development of benign prostatic hyperplasia. unassigned - 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29421536&form=6&db=m SIRT3 inhibits prostate cancer metastasis through regulation of FOXO3A by suppressing Wnt/?-catenin pathway. unassigned - 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20966168&form=6&db=m SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse. unassigned - 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26667039&form=6&db=m SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3?. unassigned - 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27071400&form=6&db=m Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-?-dependent feedback regulation of SOD2. unassigned - 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28862956&form=6&db=m Sirtuin 3 Deficiency Accelerates Hypertensive Cardiac Remodeling by Impairing Angiogenesis. unassigned - 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31242212&form=6&db=m SIRT1 deficiency interferes with membrane resealing after cell membrane injury. unassigned - 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31408587&form=6&db=m Maternal Eicosapentaenoic Acid Feeding Decreases Placental Lipid Deposition and Improves the Homeostasis of Oxidative Stress Through a Sirtuin-1 (SIRT1) Independent Manner. unassigned - 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32342656&form=6&db=m The effect of Sirt1 deficiency on Ca2+ and Na+ regulation in mouse ventricular myocytes. unassigned - 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32950974&form=6&db=m Lipopolysaccharide upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1). unassigned - 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33045622&form=6&db=m Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway. unassigned - 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33706382&form=6&db=m SIRT3 consolidates heterochromatin and counteracts senescence. unassigned - 2.3.1.286 Protein Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29076061&form=6&db=m Decreased Neuron Number and Synaptic Plasticity in SIRT3-Knockout Mice with Poor Remote Memory. unassigned - 2.3.1.286 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34335904&form=6&db=m The effects of compound centella formula on OxInflammation and silent information regulator 1 in a high-fat diet/streptozotocin-induced diabetic kidney disease rat model. unassigned - 2.3.1.286 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27453822&form=6&db=m Induction of differentiation in psoriatic keratinocytes by propylthiouracil and fructose. unassigned - 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32164488&form=6&db=m Function of hesperidin alleviating inflammation and oxidative stress responses in COPD mice might be related to SIRT1/PGC-1?/NF-?B signaling axis. unassigned - 2.3.1.286 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33609723&form=6&db=m Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis. unassigned - 2.3.1.286 Pulpitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31877121&form=6&db=m MicroRNA-506 Is Involved in Regulation of the Occurrence of Lipopolysaccharides (LPS)-Induced Pulpitis by Sirtuin 1 (SIRT1). unassigned - 2.3.1.286 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23374890&form=6&db=m Obesity and kidney disease: potential mechanisms. unassigned - 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30538800&form=6&db=m SIRT3 a Major Player in Attenuation of Hepatic Ischemia-Reperfusion Injury by Reducing ROS via Its Downstream Mediators: SOD2, CYP-D, and HIF-1?. unassigned - 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32434515&form=6&db=m Rno-microRNA-30c-5p promotes myocardial ischemia reperfusion injury in rats through activating NF-?B pathway and targeting SIRT1. unassigned - 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33241954&form=6&db=m CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia-reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation. unassigned - 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33664991&form=6&db=m SIRT1 alleviates hepatic ischemia-reperfusion injury via the miR-182-mediated XBP1/NLRP3 pathway. unassigned - 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34102281&form=6&db=m The H3K9 histone methyltransferase G9a modulates renal ischemia reperfusion injury by targeting Sirt1. unassigned - 2.3.1.286 Respiratory Distress Syndrome, Newborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31858575&form=6&db=m Budesonide and Poractant Alfa prevent bronchopulmonary dysplasia via triggering SIRT1 signaling pathway. unassigned - 2.3.1.286 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26522222&form=6&db=m Sirtuin 1 participates in the process of age-related retinal degeneration. unassigned - 2.3.1.286 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31884654&form=6&db=m The Resveratrol Prodrug JC19 Delays Retinal Degeneration in rd10 Mice. unassigned - 2.3.1.286 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32125276&form=6&db=m p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle. unassigned - 2.3.1.286 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25707573&form=6&db=m Histone deacetylase SIRT1 is reduced in systemic sclerosis and abrogates fibrotic responses by targeting TGF-ß signaling. unassigned - 2.3.1.286 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28532580&form=6&db=m Sirt1 ameliorates systemic sclerosis by targeting the mTOR pathway. unassigned - 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25088223&form=6&db=m Epigenetic coordination of acute systemic inflammation: potential therapeutic targets. unassigned - 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26868537&form=6&db=m LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2?/Notch3 pathways. unassigned - 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29680657&form=6&db=m Sirt1 S-nitrosylation induces acetylation of HMGB1 in LPS-activated RAW264.7 cells and endotoxemic mice. unassigned - 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31534623&form=6&db=m Antioxidant and Cardioprotective Effects of EPA on Early Low-Severity Sepsis through UCP3 and SIRT3 Upholding of the Mitochondrial Redox Potential. unassigned - 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31632409&form=6&db=m Impact of the Dual Deletion of the Mitochondrial Sirtuins SIRT3 and SIRT5 on Anti-microbial Host Defenses. unassigned - 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33452667&form=6&db=m Melatonin Alleviates Cardiac Dysfunction Via Increasing Sirt1-Mediated Beclin-1 Deacetylation and Autophagy During Sepsis. unassigned - 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34412757&form=6&db=m [Activation of NOD-like receptor protein 3 inflammasome mediates inflammatory response and apoptosis in septic intestinal injury model]. unassigned - 2.3.1.286 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32319664&form=6&db=m MicroRNA?138?5p regulates the development of spinal cord injury by targeting SIRT1. unassigned - 2.3.1.286 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23475622&form=6&db=m Altered expression of SIRT gene family in head and neck squamous cell carcinoma. unassigned - 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18638538&form=6&db=m Linking sirtuins, IGF-I signaling, and starvation. unassigned - 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19267881&form=6&db=m Serum withdrawal up-regulates human SIRT1 gene expression in a p53-dependent manner. unassigned - 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20547755&form=6&db=m Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells. unassigned - 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26515065&form=6&db=m Muscle Wasting in Fasting Requires Activation of NF-?B and Inhibition of AKT/Mechanistic Target of Rapamycin (mTOR) by the Protein Acetylase, GCN5. unassigned - 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26626483&form=6&db=m AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation. unassigned - 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28525743&form=6&db=m Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. unassigned - 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28756945&form=6&db=m SIRT1 Functions as a Negative Regulator of Eukaryotic Poly(A)RNA Transport. unassigned - 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32213867&form=6&db=m SIRT2 Affects Primary Cilia Formation by Regulating mTOR Signaling in Retinal Pigmented Epithelial Cells. unassigned - 2.3.1.286 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25806020&form=6&db=m Transcriptional Response of Polycomb Group Genes to Status Epilepticus in Mice is Modified by Prior Exposure to Epileptic Preconditioning. unassigned - 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29108235&form=6&db=m Regulation of SIRT3 signal related metabolic reprogramming in gastric cancer by unassigned - 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29925042&form=6&db=m SIRT2 Promotes the Migration and Invasion of Gastric Cancer through RAS/ERK/JNK/MMP-9 Pathway by Increasing PEPCK1-Related Metabolism. unassigned - 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33987098&form=6&db=m miR-1301-3p Promotes Cell Proliferation and Facilitates Cell Cycle Progression via Targeting SIRT1 in Gastric Cancer. unassigned - 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25186738&form=6&db=m A critical role for interferon regulatory factor 9 in cerebral ischemic stroke. unassigned - 2.3.1.286 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32447338&form=6&db=m Inhibition of the Peroxisome Proliferator-Activated Receptor gamma Coactivator 1-alpha (PGC-1?)/Sirtuin 3 (SIRT3) Pathway Aggravates Oxidative Stress After Experimental Subarachnoid Hemorrhage. unassigned - 2.3.1.286 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33261652&form=6&db=m Tauroursodeoxycholic acid attenuates neuronal apoptosis via the TGR5/ SIRT3 pathway after subarachnoid hemorrhage in rats. unassigned - 2.3.1.286 Tongue Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34432226&form=6&db=m Retraction Note: Sirtuin 3 inhibition induces mitochondrial stress in tongue cancer by targeting mitochondrial fission and the JNK-Fis1 biological axis. unassigned - 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22773105&form=6&db=m Cyclic AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis. unassigned - 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28935371&form=6&db=m A Sir2 family protein Rv1151c deacetylates HU to alter its DNA binding mode in Mycobacterium tuberculosis. unassigned - 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29345920&form=6&db=m Acetylation by Eis and Deacetylation by Rv1151c of Mycobacterium tuberculosis HupB: Biochemical and Structural Insight. unassigned - 2.3.1.286 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31599935&form=6&db=m Cartilage Ablation of Sirt1 Causes Inhibition of Growth Plate Chondrogenesis by Hyperactivation of mTORC1 Signaling. unassigned - 2.3.1.286 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28275188&form=6&db=m The deacetylase SIRT1 regulates the replication properties of human papillomavirus 16 E1 and E2. unassigned - 2.3.1.286 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30695683&form=6&db=m Metformin combined with nelfinavir induces SIRT3/mROS-dependent autophagy in human cervical cancer cells and xenograft in nude mice. unassigned - 2.3.1.286 Vascular Calcification http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30619890&form=6&db=m The Interplay of SIRT1 and Wnt Signaling in Vascular Calcification. unassigned - 2.3.1.286 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27897112&form=6&db=m Harnessing the Power of SIRT1 and Non-coding RNAs in Vascular Disease. unassigned - 2.3.1.286 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32679077&form=6&db=m Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity. unassigned - 2.3.1.286 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17996922&form=6&db=m Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML. unassigned - 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27536685&form=6&db=m SIRT1 and Kidney Function. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27620507&form=6&db=m Protective effects of sirtuin 3 in a murine model of sepsis-induced acute kidney injury. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30487750&form=6&db=m SIRT3 Protects Against Acute Kidney Injury via AMPK/mTOR-Regulated Autophagy. therapeutic application,unassigned 1,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31974604&form=6&db=m Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats. causal interaction,unassigned 1,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32428599&form=6&db=m Protective function of exosomes from adipose tissue-derived mesenchymal stem cells in acute kidney injury through SIRT1 pathway. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33458788&form=6&db=m Renoprotective effects of estrogen on acute kidney injury: the role of SIRT1. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34122726&form=6&db=m Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34187277&form=6&db=m Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway. therapeutic application,unassigned 1,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23056314&form=6&db=m Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25727991&form=6&db=m Silencing angiopoietin-like protein 4 (ANGPTL4) protects against lipopolysaccharide-induced acute lung injury via regulating SIRT1 /NF-kB pathway. therapeutic application,unassigned 1,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25972997&form=6&db=m Changed profile of microRNAs in acute lung injury induced by cardio-pulmonary bypass and its mechanism involved with SIRT1. causal interaction,unassigned 1,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28429673&form=6&db=m Hydroxytyrosol Attenuates LPS-Induced Acute Lung Injury in Mice by Regulating Autophagy and Sirtuin Expression. therapeutic application,unassigned 1,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28675985&form=6&db=m Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1. causal interaction,unassigned 1,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28931916&form=6&db=m Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-?B and HMGB1 pathways through the upregulation of SIRT1. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29621765&form=6&db=m Nrf2 Activation Induced by Sirt1 Ameliorates Acute Lung Injury After Intestinal Ischemia/Reperfusion Through NOX4-Mediated Gene Regulation. therapeutic application,unassigned 1,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32228886&form=6&db=m GDF-15 prevents lipopolysaccharide-mediated acute lung injury via upregulating SIRT1. therapeutic application,unassigned 1,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32419528&form=6&db=m Aloin suppresses lipopolysaccharide-induced acute lung injury by inhibiting NLRP3/NF-?B via activation of SIRT1 in mice. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33185125&form=6&db=m Depleting microRNA-146a-3p attenuates lipopolysaccharide-induced acute lung injury via up-regulating SIRT1 and mediating NF-?B pathway. therapeutic application,unassigned 1,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33260147&form=6&db=m Propofol reduces renal ischemia/reperfusion-induced acute lung injury by stimulating sirtuin 1 and inhibiting pyroptosis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22552606&form=6&db=m Hypermethylation of HIC1 Promoter and Aberrant Expression of HIC1/SIRT1 Might Contribute to the Carcinogenesis of Pancreatic Cancer. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23323102&form=6&db=m Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25367367&form=6&db=m Immunohistochemical Characterization of Large Intestinal Adenocarcinoma in the Rhesus Macaque (Macaca mulatta). causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28390310&form=6&db=m Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30683474&form=6&db=m MiR-708-5p inhibits the progression of pancreatic ductal adenocarcinoma by targeting Sirt3. therapeutic application,unassigned 1,0 2.3.1.286 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31572510&form=6&db=m Expression and role of lncRNAs in the regeneration of skeletal muscle following contusion injury. ongoing research,unassigned 1,0 2.3.1.286 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26931474&form=6&db=m Communication from Tubular Epithelial Cells to Podocytes through Sirt1 and Nicotinic Acid Metabolism. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27536685&form=6&db=m SIRT1 and Kidney Function. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28444663&form=6&db=m Transcriptional Coactivator p300 and Silent Information Regulator 1 (SIRT1) Gene Polymorphism Associated with Diabetic Kidney Disease in a Chinese Cohort. ongoing research,unassigned 1,0 2.3.1.286 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30959066&form=6&db=m P53/NRF2 mediates SIRT1's protective effect on diabetic nephropathy. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16766037&form=6&db=m Resveratrol--a boon for treating Alzheimer's disease? therapeutic application,unassigned 1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581637&form=6&db=m SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18254804&form=6&db=m Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22327552&form=6&db=m Sirtuins in cognitive ageing and Alzheimer's disease. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23417962&form=6&db=m SIRT1 and SIRT2: emerging targets in neurodegeneration. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23613875&form=6&db=m Sirtuin1: a promising serum protein marker for early detection of Alzheimer's disease. causal interaction,unassigned 1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24464653&form=6&db=m Distinct Patterns of Sirtuin Expression During Progression of Alzheimer's Disease. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27836195&form=6&db=m Design, synthesis of allosteric peptide activator for human SIRT1 and its biological evaluation in cellular model of Alzheimer's disease. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29293440&form=6&db=m Biophysical interaction of resveratrol with sirtuin pathway: Significance in Alzheimer's disease. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29883958&form=6&db=m A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1. causal interaction,unassigned 1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30208700&form=6&db=m Eriodictyol Attenuates LPS-Induced Neuroinflammation, Amyloidogenesis, and Cognitive Impairments via the Inhibition of NF-?B in Male C57BL/6J Mice and BV2 Microglial Cells. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30510627&form=6&db=m Neuroprotective Mechanisms of Resveratrol in Alzheimer's Disease: Role of SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31217784&form=6&db=m Rational design of novel sirtuin 1 activators via structure-activity insights from application of QSAR modeling. causal interaction,unassigned 1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32124252&form=6&db=m Correlation Between SIRT2 3'UTR Gene Polymorphism and the Susceptibility to Alzheimer's Disease. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32145065&form=6&db=m Impact of neural stem cell-derived extracellular vesicles on mitochondrial dysfunction, sirtuin 1 level, and synaptic deficits in Alzheimer's disease. causal interaction,unassigned 1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32441492&form=6&db=m Bisdemethoxycurcumin inhibits oxidative stress and antagonizes Alzheimer's disease by up-regulating SIRT1. therapeutic application,unassigned 1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32700357&form=6&db=m RTN4B-mediated suppression of Sirtuin 2 activity ameliorates ?-amyloid pathology and cognitive impairment in Alzheimer's disease mouse model. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32926246&form=6&db=m Positive association of a Sirt1 variant and parameters of oxidative stress on Alzheimer's disease. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33098511&form=6&db=m Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33164543&form=6&db=m The probable role of insulin resistance and SIRT1 proteins in the Alzheimer's disease. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581637&form=6&db=m SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21896316&form=6&db=m Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30479062&form=6&db=m Reduced sirtuin 1/adenosine monophosphate-activated protein kinase in amyotrophic lateral sclerosis patient-derived mesenchymal stem cells can be restored by resveratrol. therapeutic application,unassigned 1,0 2.3.1.286 Aneurysm, Dissecting http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32072402&form=6&db=m SIRT1 protects against aortic dissection by regulating AP-1/decorin signaling-mediated PDCD4 activation. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Anhedonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30705425&form=6&db=m SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Anhedonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34355499&form=6&db=m The role of SIRT1 in the basolateral amygdala in depression-like behaviors in mice. therapeutic application,unassigned 1,0 2.3.1.286 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27650558&form=6&db=m Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm. causal interaction,unassigned 1,0 2.3.1.286 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29396144&form=6&db=m Mouse macrophage specific knockout of SIRT1 influences macrophage polarization and promotes angiotensin II-induced abdominal aortic aneurysm formation. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Aortic Valve Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22493735&form=6&db=m Sirt1 inhibits resistin expression in aortic stenosis. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21305531&form=6&db=m Switching gears to an arthritis gene expression network by SirT1 cleavage. ongoing research,unassigned 1,0 2.3.1.286 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24498364&form=6&db=m Myeloid deletion of SIRT1 aggravates serum transfer arthritis in mice via nuclear factor-?B activation. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28329314&form=6&db=m SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32381568&form=6&db=m Implication of the deacetylase sirtuin-1 on synovial angiogenesis and persistence of experimental arthritis. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32615849&form=6&db=m Impact of glucocorticoids on systemic sirtuin 1 expression and activity in rats with adjuvant-induced arthritis. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26987484&form=6&db=m Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20697895&form=6&db=m Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24498364&form=6&db=m Myeloid deletion of SIRT1 aggravates serum transfer arthritis in mice via nuclear factor-?B activation. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33530998&form=6&db=m MiR-140-3p inhibits the cell viability and promotes apoptosis of synovial fibroblasts in rheumatoid arthritis through targeting sirtuin 3. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34309725&form=6&db=m Emerging epigenetic targets in rheumatoid arthritis. causal interaction,unassigned 1,0 2.3.1.286 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23897750&form=6&db=m Dysfunction of endothelial progenitor cells from smokers and COPD patients due to increased DNA damage and senescence. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19763917&form=6&db=m Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-X(L) and survivin. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23852118&form=6&db=m SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons. causal interaction,unassigned 1,0 2.3.1.286 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26405826&form=6&db=m The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes. causal interaction,unassigned 1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21118843&form=6&db=m SIRT1 inhibits angiotensin II-induced vascular smooth muscle cell hypertrophy. causal interaction,unassigned 1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23224247&form=6&db=m Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23878368&form=6&db=m Resveratrol Blunts the Positive Effects of Exercise Training on Cardiovascular Health in Aged Men. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25063737&form=6&db=m SIRT1 in cardiovascular aging. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27573670&form=6&db=m SIRT1 mediates the actions of PPAR? on the oxLDL-triggered migration and proliferation of vascular smooth muscle cells. causal interaction,unassigned 1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28029409&form=6&db=m Serum concentrations and gene expression of sirtuin 1 in healthy and slightly overweight subjects after caloric restriction or resveratrol supplementation: A randomized trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28765952&form=6&db=m mTOR signaling promotes foam cell formation and inhibits foam cell egress through suppressing the SIRT1 signaling pathway. diagnostic usage,unassigned 1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28870631&form=6&db=m The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis. ongoing research,unassigned 1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29299128&form=6&db=m Estrogen modulates vascular smooth muscle cell function through downregulation of SIRT1. therapeutic application,unassigned 1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29787963&form=6&db=m SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31059091&form=6&db=m SIRT4 suppresses the PI3K/Akt/NF??B signaling pathway and attenuates HUVEC injury induced by oxLDL. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31738037&form=6&db=m MiR-132 relieves vascular endothelial inflammation and improve endothelial function in atherosclerosis rats by regulating SIRT1. ongoing research,unassigned 1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31901246&form=6&db=m Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial. causal interaction,unassigned 1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32758058&form=6&db=m Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32796661&form=6&db=m Impact of Short-Term Hypoxia on Sirtuins as Regulatory Elements in HUVECs. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33519472&form=6&db=m Acacetin Protects Against High Glucose-Induced Endothelial Cells Injury by Preserving Mitochondrial Function via Activating Sirt1/Sirt3/AMPK Signals. therapeutic application,unassigned 1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33562658&form=6&db=m The Endothelium as a Target for Anti-Atherogenic Therapy: A Focus on the Epigenetic Enzymes EZH2 and SIRT1. ongoing research,unassigned 1,0 2.3.1.286 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25770475&form=6&db=m TNF? Regulates SIRT1 Cleavage during Ocular Autoimmune Disease. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Azoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34355990&form=6&db=m microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials. ongoing research,unassigned 1,0 2.3.1.286 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23908241&form=6&db=m A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31357491&form=6&db=m Discovery of (5-Phenylfuran-2-yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Bone Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31270711&form=6&db=m SIRT1 Activation Attenuates Bone Cancer Pain by Inhibiting mGluR1/5. therapeutic application,unassigned 1,0 2.3.1.286 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26287518&form=6&db=m Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs. therapeutic application,unassigned 1,0 2.3.1.286 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30456702&form=6&db=m Sirtuin 1 inhibits TNF-?-mediated osteoclastogenesis of bone marrow-derived macrophages through both ROS generation and TRPV1 activation. therapeutic application,unassigned 1,0 2.3.1.286 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30738214&form=6&db=m Sirtuins and FoxOs in osteoporosis and osteoarthritis. diagnostic usage,therapeutic application,unassigned 1,2,0 2.3.1.286 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33867853&form=6&db=m Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33421349&form=6&db=m The AMPAR antagonist perampanel protects the neurovascular unit against traumatic injury via regulating Sirt3. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Brain Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29862442&form=6&db=m Sirt3 inhibits cerebral ischemia-reperfusion injury through normalizing Wnt/?-catenin pathway and blocking mitochondrial fission. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29375306&form=6&db=m SIRT1/PGC-1? Signaling Promotes Mitochondrial Functional Recovery and Reduces Apoptosis after Intracerebral Hemorrhage in Rats. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30090498&form=6&db=m SIRT1 attenuated oxidative stress induced by methyl tert-butyl ether in HT22 cells. causal interaction,unassigned 1,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31089056&form=6&db=m Polydatin prevents the induction of secondary brain injury after traumatic brain injury by protecting neuronal mitochondria. causal interaction,diagnostic usage,unassigned 1,1,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31527356&form=6&db=m The molecular mechanism of Sirt1 signaling pathway in brain injury of newborn rats exposed to hyperoxia. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32357375&form=6&db=m Resveratrol Relieves Hyperoxia-Induced Brain Injury in Neonatal Rats by Activating Sirt1. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34395427&form=6&db=m Exosomes Derived From Adipose-Derived Mesenchymal Stem Cells Ameliorate Radiation-Induced Brain Injury by Activating the SIRT1 Pathway. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22828134&form=6&db=m Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo. therapeutic application,unassigned 1,0 2.3.1.286 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26743530&form=6&db=m Low-Molecular-Weight Fucoidan Attenuates Mitochondrial Dysfunction and Improves Neurological Outcome After Traumatic Brain Injury in Aged Mice: Involvement of Sirt3. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28017962&form=6&db=m SIRT1 plays a neuroprotective role in traumatic brain injury in rats via inhibiting the p38 MAPK pathway. causal interaction,unassigned 1,0 2.3.1.286 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29257276&form=6&db=m Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16395277&form=6&db=m Resveratrol mimics ischemic preconditioning in the brain. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19288225&form=6&db=m Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22971966&form=6&db=m Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24058702&form=6&db=m Epsilon PKC Increases Brain Mitochondrial SIRT1 Protein Levels via Heat Shock Protein 90 following Ischemic Preconditioning in Rats. causal interaction,unassigned 1,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28888980&form=6&db=m Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30532738&form=6&db=m Brain SIRT1 Mediates Metabolic Homeostasis and Neuroprotection. ongoing research,unassigned 1,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33924243&form=6&db=m Role of SIRT1 in Isoflurane Conditioning-Induced Neurovascular Protection against Delayed Cerebral Ischemia Secondary to Subarachnoid Hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23612572&form=6&db=m Germline copy number variation of genes involved in chromatin remodelling in families suggestive of Li-Fraumeni syndrome with brain tumours. diagnostic usage,therapeutic application,unassigned 1,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19750026&form=6&db=m Can Sir(2) regulate cancer? ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19754813&form=6&db=m Expression and sequence of canine SIRT2 and p53 genes in canine mammary tumour cells - effects on downstream targets Wip1 and p21/Cip1. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22465953&form=6&db=m Regulation of SIRT1 activity by genotoxic stress. therapeutic application,unassigned 1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22623155&form=6&db=m MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23323102&form=6&db=m Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23474493&form=6&db=m CBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23598413&form=6&db=m Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24126058&form=6&db=m hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1. therapeutic application,unassigned 1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24897117&form=6&db=m Frizzled 7 expression is positively regulated by SIRT1 and ?-catenin in breast cancer cells. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25417701&form=6&db=m A positive role of DBC1 in PEA3-mediated progression of estrogen receptor-negative breast cancer. therapeutic application,unassigned 1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25562154&form=6&db=m The SIRT 3 expression profile is associated with pathological and clinical outcomes in human breast cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25610865&form=6&db=m DBC1/CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor. therapeutic application,unassigned 1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26459286&form=6&db=m Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent ?-H2AX and telomerase regulation in triple-negative breast cancer. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27165221&form=6&db=m New Gene Profiling in Determination of Breast Cancer Recurrence and Prognosis in Iranian Women. causal interaction,diagnostic usage,unassigned 1,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27270321&form=6&db=m Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28944911&form=6&db=m MicroRNA?3666 inhibits breast cancer cell proliferation by targeting sirtuin 7. therapeutic application,unassigned 1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29679549&form=6&db=m CHM-1, a novel microtubule-destabilizing agent exhibits antitumor activity via inducing the expression of SIRT2 in human breast cancer cells. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30365149&form=6&db=m I157172, a novel inhibitor of cystathionine ?-lyase, inhibits growth and migration of breast cancer cells via SIRT1-mediated deacetylation of STAT3. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30982660&form=6&db=m Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31063745&form=6&db=m SIRT1 Regulates Lysosome Function and Exosome Secretion. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31077613&form=6&db=m Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer. causal interaction,unassigned 1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32442721&form=6&db=m Emerging role of sirtuins in breast cancer metastasis and multidrug resistance: Implication for novel therapeutic strategies targeting sirtuins. causal interaction,unassigned 1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32659678&form=6&db=m Material basis, effect, and mechanism of ethanol extract of Pinellia ternata tubers on oxidative stress-induced cell senescence. therapeutic application,unassigned 1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33545830&form=6&db=m pH sensitive liposomes assisted specific and improved breast cancer therapy using co-delivery of SIRT1 shRNA and Docetaxel. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33789098&form=6&db=m SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation. therapeutic application,unassigned 1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34338986&form=6&db=m SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Bronchopulmonary Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22272724&form=6&db=m Sirtuin1 in tracheal aspirate leukocytes: possible role in the development of bronchopulmonary dysplasia in premature infants. causal interaction,unassigned 1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16269335&form=6&db=m Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18235501&form=6&db=m DBC1 is a negative regulator of SIRT1. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18414679&form=6&db=m The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19017485&form=6&db=m SIRT1: roles in aging and cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20097625&form=6&db=m Role of SIRT1 in homologous recombination. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21807113&form=6&db=m Sirt1 deacetylates c-Myc and promotes c-Myc/Max association. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21912480&form=6&db=m Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22749020&form=6&db=m Metabolic regulation by SIRT3: implications for tumorigenesis. causal interaction,unassigned 1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23050959&form=6&db=m Janus-faced role of SIRT1 in tumorigenesis. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23561972&form=6&db=m Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23800187&form=6&db=m Role of SIRT3 in the regulation of redox balance during oral carcinogenesis. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24959379&form=6&db=m SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation. causal interaction,unassigned 1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25119660&form=6&db=m MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25815111&form=6&db=m SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27637077&form=6&db=m SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status. therapeutic application,unassigned 1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28786706&form=6&db=m Low Rap1-interacting factor 1 and sirtuin 6 expression predict poor outcome in radiotherapy-treated Hodgkin lymphoma patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28841456&form=6&db=m Resveratrol improves smooth muscle carcinogenesis in the progression of chronic prostatitis via the downregulation of c-kit/SCF by activating Sirt1. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30662803&form=6&db=m Vimentin acetylation is involved in SIRT5-mediated hepatocellular carcinoma migration. causal interaction,unassigned 1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30881341&form=6&db=m Insulin/IGF-1R, SIRT1, and FOXOs Pathways-An Intriguing Interaction Platform for Bone and Osteosarcoma. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31394122&form=6&db=m Deacetylation of ?-catenin by SIRT1 regulates self-renewal and oncogenesis of liver cancer stem cells. ongoing research,unassigned 1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31442917&form=6&db=m Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32114521&form=6&db=m 3-Iodothyronamine and 3,5,3'-triiodo-L-thyronine reduce SIRT1 protein expression in the HepG2 cell line. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33390835&form=6&db=m The Regulatory Effect of SIRT1 on Extracellular Microenvironment Remodeling. ongoing research,unassigned 1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33438275&form=6&db=m Sirtuin 1 promotes autophagy and proliferation of endometrial cancer cells by reducing acetylation level of LC3. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34184746&form=6&db=m USP31 acetylation at Lys1264 is essential for its activity and cervical cancer cell growth. therapeutic application,unassigned 1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34500051&form=6&db=m Mitochondrial sirtuins genetic variations and gastric cancer risk: Evidence from retrospective observational study. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25227106&form=6&db=m Effects of downregulation of SIRT3 expression on proliferation and apoptosis in esophageal squamous cell carcinoma EC9706 cells and its molecular mechanisms. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25424420&form=6&db=m Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28904318&form=6&db=m CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28943922&form=6&db=m Obesity accelerates murine gastric cancer growth by modulating the Sirt1/YAP pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29467843&form=6&db=m Sirtuin 7 promotes colorectal carcinoma proliferation and invasion through the inhibition of E-cadherin. therapeutic application,unassigned 1,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31442917&form=6&db=m Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22277911&form=6&db=m Correction: Sirtuin 1 Is Upregulated in a Subset of Hepatocellular Carcinomas where It Is Essential for Telomere Maintenance and Tumor Cell Growth. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23224434&form=6&db=m The tumor suppressor protein menin inhibits NF-?B-mediated transactivation through recruitment of Sirt1 in hepatocellular carcinoma. therapeutic application,unassigned 1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25119660&form=6&db=m MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25404446&form=6&db=m Prognostic role of SIRT1 in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25652855&form=6&db=m [Growth inhibition of human hepatocellular carcinoma by miRNA-204 via down-regulation of Bcl-2 and Sirt1 expression]. therapeutic application,unassigned 1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25736100&form=6&db=m Suppression of SIRT1 activity in noncancerous tissues of HCC: possible association with non-B non-C hepatitis pathogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25772107&form=6&db=m SirT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26042459&form=6&db=m Increased SIRT3 Expression and Antioxidant Defense under Hyperglycemic Conditions in HepG2 Cells. ongoing research,unassigned 1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26824501&form=6&db=m SIRT1 increases YAP- and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26922015&form=6&db=m [Role of SIRT3 in regulating proliferation of hepatocellular carcinoma cells in vitro]. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27090017&form=6&db=m MicroRNA-133b inhibits hepatocellular carcinoma cell progression by targeting Sirt1. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,2 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27428722&form=6&db=m Bioinformatics Prediction and Experimental Validation of MicroRNAs Involved in Cross-Kingdom Interaction. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27748572&form=6&db=m miR-204-5p targeting SIRT1 regulates hepatocellular carcinoma progression. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,2,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28242208&form=6&db=m Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription. causal interaction,diagnostic usage,unassigned 1,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28338198&form=6&db=m The expression of SIRT3 in primary hepatocellular carcinoma and the mechanism of its tumor suppressing effects. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28720061&form=6&db=m The long non-coding RNA MALAT1 promotes the migration and invasion of hepatocellular carcinoma by sponging miR-204 and releasing SIRT1. causal interaction,unassigned 1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28881735&form=6&db=m Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28964787&form=6&db=m Negative regulation of Sirtuin 1 by AMP-activated protein kinase promotes metformin-induced senescence in hepatocellular carcinoma xenografts. diagnostic usage,ongoing research,unassigned 1,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29630527&form=6&db=m MiR-29a suppresses cell proliferation by targeting SIRT1 in hepatocellular carcinoma. causal interaction,unassigned 1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30552782&form=6&db=m SIRT4 Depletion Promotes HCC Tumorigenesis through Regulating AMPK?/mTOR Axis. therapeutic application,unassigned 1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30664838&form=6&db=m ?-hydroxybutyrate protects hepatocytes against endoplasmic reticulum stress in a sirtuin 1-independent manner. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31430957&form=6&db=m Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Is Reversed by SIRT1. therapeutic application,unassigned 1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31778683&form=6&db=m Molecular docking and mechanisms of fusaric acid induced mitochondrial sirtuin aberrations in glycolytically and oxidatively poised human hepatocellular carcinoma (HepG2) cells. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32017171&form=6&db=m Downregulation of circular RNA circPVT1 restricts cell growth of hepatocellular carcinoma through downregulation of Sirtuin 7 via microRNA-3666. ongoing research,unassigned 1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32114521&form=6&db=m 3-Iodothyronamine and 3,5,3'-triiodo-L-thyronine reduce SIRT1 protein expression in the HepG2 cell line. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29552768&form=6&db=m The expression and mechanism of Sirt1 and AMPK in nonsmall cell lung cancer. ongoing research,unassigned 1,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32319822&form=6&db=m Long Noncoding RNA SNHG10 Sponges miR-543 to Upregulate Tumor Suppressive SIRT1 in Nonsmall Cell Lung Cancer. causal interaction,unassigned 1,0 2.3.1.286 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25624750&form=6&db=m Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells. therapeutic application,unassigned 1,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20685942&form=6&db=m Mitochondrial SIRT3 and heart disease. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21212461&form=6&db=m Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21414296&form=6&db=m Upregulation of SIRT1 deacetylase in phenylephrine-treated cardiomyoblasts. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22055503&form=6&db=m PPAR?-Sirt1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway. therapeutic application,unassigned 1,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22119802&form=6&db=m The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24786827&form=6&db=m ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25871545&form=6&db=m Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26298192&form=6&db=m Resveratrol ameliorates cardiac oxidative stress in diabetes through deacetylation of NFkB-p65 and histone 3. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29774488&form=6&db=m The effect of oxygen in Sirt3-mediated myocardial protection: a proof-of-concept study in cultured cardiomyoblasts. therapeutic application,unassigned 1,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30414383&form=6&db=m Sirtuin 1 represses PKC-? activity through regulating interplay of acetylation and phosphorylation in cardiac hypertrophy. therapeutic application,unassigned 1,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30647820&form=6&db=m Exogenous Hydrogen Sulfide Supplement Attenuates Isoproterenol-Induced Myocardial Hypertrophy in a Sirtuin 3-Dependent Manner. diagnostic usage,unassigned 1,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30856082&form=6&db=m 1.25 Dihydroxyvitamin D3 Attenuates Hypertrophy Markers in Cardiomyoblast H9c2 Cells: Evaluation of Sirtuin3 mRNA and Protein Level. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32468895&form=6&db=m Endothelial Sirtuin 3 Dictates Glucose Transport to Cardiomyocyte and Sensitizes Pressure Overload-Induced Heart Failure. ongoing research,unassigned 1,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33886061&form=6&db=m miR-145-5p targets paxillin to attenuate angiotensin II-induced pathological cardiac hypertrophy via downregulation of Rac 1, pJNK, p-c-Jun, NFATc3, ANP and by Sirt-1 upregulation. therapeutic application,unassigned 1,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31776436&form=6&db=m Correction to: ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation. therapeutic application,unassigned 1,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32164457&form=6&db=m Role of Deranged Energy Deprivation Signaling in the Pathogenesis of Cardiac and Renal Disease in States of Perceived Nutrient Overabundance. causal interaction,unassigned 1,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33869205&form=6&db=m Inhibiting miR-22 Alleviates Cardiac Dysfunction by Regulating Sirt1 in Septic Cardiomyopathy. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19303434&form=6&db=m Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway. therapeutic application,unassigned 1,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25665036&form=6&db=m Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25766524&form=6&db=m SIRT1 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the Oxidative Stress and p38MAPK Pathways. therapeutic application,unassigned 1,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27446329&form=6&db=m Resveratrol inhibits doxorubicin-induced cardiotoxicity via sirtuin 1 activation in H9c2 cardiomyocytes. therapeutic application,unassigned 1,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28456571&form=6&db=m Erythropoietin activates SIRT1 to protect human cardiomyocytes against doxorubicin-induced mitochondrial dysfunction and toxicity. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28928469&form=6&db=m Activation of miR-34a-5p/Sirt1/p66shc pathway contributes to doxorubicin-induced cardiotoxicity. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29966675&form=6&db=m Melatonin improves cardiac and mitochondrial function during doxorubicin-induced cardiotoxicity: A possible role for peroxisome proliferator-activated receptor gamma coactivator 1-alpha and sirtuin activity? causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31266854&form=6&db=m Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity. therapeutic application,unassigned 1,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31303273&form=6&db=m Dosing depending on SIRT3 activity attenuates doxorubicin-induced cardiotoxicity via elevated tolerance against mitochondrial dysfunction and oxidative stress. causal interaction,unassigned 1,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31733141&form=6&db=m PGC1? activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades. therapeutic application,unassigned 1,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32112883&form=6&db=m Dihydromyricetin alleviates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1. therapeutic application,unassigned 1,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34422218&form=6&db=m Protection against Doxorubicin-Related Cardiotoxicity by Jaceosidin Involves the Sirt1 Signaling Pathway. therapeutic application,unassigned 1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22939883&form=6&db=m SIRT1 in metabolic syndrome: Where to target matters. therapeutic application,unassigned 1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24587358&form=6&db=m SIRT1 gene polymorphisms affect the protein expression in cardiovascular diseases. ongoing research,unassigned 1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25233986&form=6&db=m SIRT1 gene variants are related to risk of childhood obesity. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,1 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25252293&form=6&db=m The effect of the SIRT1 2827 A>G polymorphism, resveratrol, exercise, age and occupation in Turkish population with cardiovascular disease. ongoing research,unassigned 1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25323555&form=6&db=m Age-dependent tissue expression patterns of Sirt1 in senescence-accelerated mice. therapeutic application,unassigned 1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25815111&form=6&db=m SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27078640&form=6&db=m Genetic and Functional Sequence Variants of the SIRT3 Gene Promoter in Myocardial Infarction. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27536685&form=6&db=m SIRT1 and Kidney Function. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28579512&form=6&db=m Homocysteine up-regulates endothelin type A receptor in vascular smooth muscle cells through Sirt1/ERK1/2 signaling pathway. therapeutic application,unassigned 1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30030618&form=6&db=m Effect of oral appliance on circulating leukocyte telomere length and SIRT1 in obstructive sleep apnea. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31106631&form=6&db=m Resveratrol inhibits parathyroid hormone-induced apoptosis in human aortic smooth muscle cells by upregulating sirtuin 1. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31666438&form=6&db=m SIRT1 and Gender Differences in Atherosclerotic Cardiovascular Disease. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31752013&form=6&db=m Tumor Necrosis Factor-alpha (TNF-?) Enhances miR-155-Mediated Endothelial Senescence by Targeting Sirtuin1 (SIRT1). ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32472237&form=6&db=m CD38: A Potential Therapeutic Target in Cardiovascular Disease. causal interaction,unassigned 1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33079829&form=6&db=m Improvement of Cardiac Function in Rats With Myocardial Infarction by Low-Intensity to Moderate-Intensity Endurance Exercise Is Associated With Normalization of Klotho and SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21501079&form=6&db=m Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans. causal interaction,unassigned 1,0 2.3.1.286 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25660075&form=6&db=m Acetylated 8-oxoguanine DNA glycosylase 1 and its relationship with p300 and SIRT1 in lens epithelium cells from age-related cataract. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27990356&form=6&db=m MicroRNA-34a promoting apoptosis of human lens epithelial cells through down-regulation of B-cell lymphoma-2 and silent information regulator. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28679650&form=6&db=m Effects of microRNA-211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.3.1.286 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31338869&form=6&db=m miR-23b-3p regulates apoptosis and autophagy via suppressing SIRT1 in lens epithelial cells. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29375306&form=6&db=m SIRT1/PGC-1? Signaling Promotes Mitochondrial Functional Recovery and Reduces Apoptosis after Intracerebral Hemorrhage in Rats. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29970985&form=6&db=m Sirt3 Ameliorates Oxidative Stress and Mitochondrial Dysfunction After Intracerebral Hemorrhage in Diabetic Rats. causal interaction,unassigned 1,0 2.3.1.286 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34149393&form=6&db=m Krüppel-Like Factor 6 Silencing Prevents Oxidative Stress and Neurological Dysfunction Following Intracerebral Hemorrhage via Sirtuin 5/Nrf2/HO-1 Axis. therapeutic application,unassigned 1,0 2.3.1.286 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34053242&form=6&db=m The Role of NLRP3 Inflammasome in Cerebrovascular Diseases Pathology and Possible Therapeutic Targets. therapeutic application,unassigned 1,0 2.3.1.286 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34178728&form=6&db=m Sirtuin Control of Mitochondrial Dysfunction, Oxidative Stress, and Inflammation in Chagas Disease Models. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Cholangitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32193100&form=6&db=m Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-?B signaling pathway. causal interaction,diagnostic usage,unassigned 1,2,0 2.3.1.286 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27816442&form=6&db=m Metformin impairs systemic bile acid homeostasis through regulating SIRT1 protein levels. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30061734&form=6&db=m 18?-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway. therapeutic application,unassigned 1,0 2.3.1.286 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30928103&form=6&db=m Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPAR?. causal interaction,unassigned 1,0 2.3.1.286 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32116682&form=6&db=m Baicalin Protects Against 17?-Ethinylestradiol-Induced Cholestasis via the Sirtuin 1/Hepatic Nuclear Receptor-1?/Farnesoid X Receptor Pathway. therapeutic application,unassigned 1,0 2.3.1.286 Choroidal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26174951&form=6&db=m SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Choroidal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28886036&form=6&db=m Potential role of sirtuin 1 in Müller glial cells in mice choroidal neovascularization. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24850427&form=6&db=m Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut. ongoing research,unassigned 1,0 2.3.1.286 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27085036&form=6&db=m Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29375382&form=6&db=m Bergenin, Acting as an Agonist of PPAR?, Ameliorates Experimental Colitis in Mice through Improving Expression of SIRT1, and Therefore Inhibiting NF-?B-Mediated Macrophage Activation. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30147698&form=6&db=m Reciprocal Regulation Between Smad7 and Sirt1 in the Gut. causal interaction,unassigned 1,0 2.3.1.286 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34162146&form=6&db=m Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/ROR?/NF-?B signaling pathways. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18414679&form=6&db=m The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,4 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24118446&form=6&db=m Amurensin G enhances the susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity of cancer stem-like cells of HCT-15 cells. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29374515&form=6&db=m Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29556386&form=6&db=m Role of microRNAs in the resistance of colorectal cancer to chemoradiotherapy. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30282801&form=6&db=m Sirtuin 7-mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32151067&form=6&db=m Ginsenoside Rp1, A Ginsenoside Derivative, Augments Anti-Cancer Effects of Actinomycin D via Downregulation of an AKT-SIRT1 Pathway. ongoing research,unassigned 1,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32636443&form=6&db=m Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for ?-catenin or MITF in colon cancer and melanoma cells. therapeutic application,unassigned 1,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28390310&form=6&db=m Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28923398&form=6&db=m SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,2,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29363918&form=6&db=m Intratumoral heterogeneity for inactivating frameshift mutation of CUX1 and SIRT1 genes in gastric and colorectal cancers. diagnostic usage,unassigned 1,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29373899&form=6&db=m Mitochondrial Effects of Teucrium Polium and Prosopis Farcta Extracts in Colorectal Cancer Cells causal interaction,diagnostic usage,unassigned 1,1,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29467843&form=6&db=m Sirtuin 7 promotes colorectal carcinoma proliferation and invasion through the inhibition of E-cadherin. therapeutic application,unassigned 1,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29584552&form=6&db=m SIRT1 in Colorectal Cancer: A Friend or Foe? diagnostic usage,unassigned 1,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32312920&form=6&db=m Sirt3 regulates the level of mitochondrial DNA repair activity through deacetylation of NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 in colorectal cancer. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32323786&form=6&db=m Catalpol?mediated microRNA?34a suppresses autophagy and malignancy by regulating SIRT1 in colorectal cancer. therapeutic application,unassigned 1,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34360883&form=6&db=m Colorectal Cancer Apoptosis Induced by Dietary ?-Valerobetaine Involves PINK1/Parkin Dependent-Mitophagy and SIRT3. therapeutic application,unassigned 1,0 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22364258&form=6&db=m MicroRNA-34a regulates the longevity-associated protein, SIRT1, in coronary artery disease: Effect of statins on SIRT1 and microRNA-34a expression. ongoing research,unassigned 1,0 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25045415&form=6&db=m Circulating levels of sirtuin 4, a potential marker of oxidative metabolism, related to coronary artery disease in obese patients suffering from NAFLD, with normal or slightly increased liver enzymes. diagnostic usage,ongoing research,unassigned 1,1,0 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25233986&form=6&db=m SIRT1 gene variants are related to risk of childhood obesity. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,1 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27033026&form=6&db=m Beneficial effects of omega-3 and vitamin E coadministration on gene expression of SIRT1 and PGC1? and serum antioxidant enzymes in patients with coronary artery disease. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30186546&form=6&db=m Corrigendum to "Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes". diagnostic usage,unassigned 1,0 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31797473&form=6&db=m Effects of crocin and saffron aqueous extract on gene expression of SIRT1, AMPK, LOX1, NF-?B, and MCP-1 in patients with coronary artery disease: A randomized placebo-controlled clinical trial. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32106619&form=6&db=m Ticagrelor Increases SIRT1 and HES1 mRNA Levels in Peripheral Blood Cells from Patients with Stable Coronary Artery Disease and Chronic Obstructive Pulmonary Disease. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.3.1.286 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32758884&form=6&db=m COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23778143&form=6&db=m Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27536685&form=6&db=m SIRT1 and Kidney Function. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Deafness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28329314&form=6&db=m SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Dementia, Vascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31602904&form=6&db=m [Effect of triptolide on cognitive dysfunction in vascular dementia rats through SIRT1/NF-?B signaling pathway]. diagnostic usage,unassigned 1,0 2.3.1.286 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33920458&form=6&db=m Melatonin Inhibits Dengue Virus Infection via the Sirtuin 1-Mediated Interferon Pathway. therapeutic application,unassigned 1,0 2.3.1.286 Dermatitis, Atopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33256152&form=6&db=m Siraitia grosvenorii Residual Extract Attenuates Atopic Dermatitis by Regulating Immune Dysfunction and Skin Barrier Abnormality. causal interaction,unassigned 1,0 2.3.1.286 Dermatitis, Atopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33571899&form=6&db=m A combination of Olea europaea leaf extract and Spirodela polyrhiza extract alleviates atopic dermatitis by modulating immune balance and skin barrier function in a 1-chloro-2,4-dinitrobenzene-induced murine model. causal interaction,unassigned 1,0 2.3.1.286 Dermatitis, Atopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33911634&form=6&db=m The Expression of Epidermal Stem Cell Marker and SIRT1 in Atopic Dermatitis: A Discussion of Regenerative Potential. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 2.3.1.286 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29072367&form=6&db=m Reappraisal of metallothionein: Clinical implications for patients with diabetes mellitus. causal interaction,unassigned 1,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23918588&form=6&db=m Effects of Resveratrol in Patients With Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24073959&form=6&db=m Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet. therapeutic application,unassigned 1,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28444663&form=6&db=m Transcriptional Coactivator p300 and Silent Information Regulator 1 (SIRT1) Gene Polymorphism Associated with Diabetic Kidney Disease in a Chinese Cohort. ongoing research,unassigned 1,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29387206&form=6&db=m Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1. ongoing research,unassigned 1,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30649099&form=6&db=m SIRT1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30701554&form=6&db=m Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double-blind placebo controlled clinical trial. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33901999&form=6&db=m Ellagic acid protects against diabetic cardiomyopathy in rats by stimulating cardiac silent information regulator 1 signaling. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34045876&form=6&db=m Roux-en-Y Gastric Bypass Improves Hepatic Glucose Metabolism Involving Upregulation of Sirt1 in Type 2 Diabetes Mellitus. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34313929&form=6&db=m MicroRNA-93-5p participates in type 2 diabetic retinopathy through targeting Sirt1. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29027826&form=6&db=m Dietary advanced glycated end-products and medicines influence the expression of SIRT1 and DDOST in peripheral mononuclear cells from long-term type 1 diabetes patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1 2.3.1.286 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30846716&form=6&db=m Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21873205&form=6&db=m Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21949662&form=6&db=m Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty (fa/fa) rats: a model of type 2 diabetes. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22064865&form=6&db=m Interferon gamma (IFN-?) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22562959&form=6&db=m Roles and Tissue Source of Adiponectin Involved in Lifestyle Modifications. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23918588&form=6&db=m Effects of Resveratrol in Patients With Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24073959&form=6&db=m Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet. therapeutic application,unassigned 1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26463981&form=6&db=m The sirtuins: Markers of metabolic health. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27058248&form=6&db=m Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28444663&form=6&db=m Transcriptional Coactivator p300 and Silent Information Regulator 1 (SIRT1) Gene Polymorphism Associated with Diabetic Kidney Disease in a Chinese Cohort. ongoing research,unassigned 1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29387206&form=6&db=m Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1. ongoing research,unassigned 1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29957104&form=6&db=m Pomegranate Juice Increases Sirtuin1 Protein in Peripheral Blood Mononuclear Cell from Patients with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trial. diagnostic usage,therapeutic application,unassigned 1,2,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30442237&form=6&db=m MiR-138-5p affects insulin resistance to regulate type 2 diabetes progression through inducing autophagy in HepG2 cells by regulating SIRT1. therapeutic application,unassigned 1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30532738&form=6&db=m Brain SIRT1 Mediates Metabolic Homeostasis and Neuroprotection. ongoing research,unassigned 1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30572719&form=6&db=m Differential expressions of SIRT1, SIRT3, and SIRT4 in peripheral blood mononuclear cells from patients with type 2 diabetic retinopathy. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30649099&form=6&db=m SIRT1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30701554&form=6&db=m Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double-blind placebo controlled clinical trial. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31333735&form=6&db=m Serum sirtuin 1 protein as a potential biomarker for type 2 diabetes: Increased expression of sirtuin 1 and the correlation with microRNAs. causal interaction,diagnostic usage,unassigned 1,2,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31901246&form=6&db=m Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial. causal interaction,unassigned 1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34045876&form=6&db=m Roux-en-Y Gastric Bypass Improves Hepatic Glucose Metabolism Involving Upregulation of Sirt1 in Type 2 Diabetes Mellitus. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34313929&form=6&db=m MicroRNA-93-5p participates in type 2 diabetic retinopathy through targeting Sirt1. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33304318&form=6&db=m SIRT1 Antagonizes Oxidative Stress in Diabetic Vascular Complication. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26209361&form=6&db=m SIRT2 regulates microtubule stabilization in diabetic cardiomyopathy. therapeutic application,unassigned 1,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29674007&form=6&db=m Mst1 inhibits Sirt3 expression and contributes to diabetic cardiomyopathy through inhibiting Parkin-dependent mitophagy. therapeutic application,unassigned 1,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30216438&form=6&db=m LncRNA HOTAIR functions as a competing endogenous RNA to upregulate SIRT1 by sponging miR-34a in diabetic cardiomyopathy. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31100876&form=6&db=m The Role of Heme Oxygenase 1 in the Protective Effect of Caloric Restriction against Diabetic Cardiomyopathy. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31210844&form=6&db=m Tetrahydrocurcumin Ameliorates Diabetic Cardiomyopathy by Attenuating High Glucose-Induced Oxidative Stress and Fibrosis via Activating the SIRT1 Pathway. causal interaction,unassigned 1,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31318577&form=6&db=m The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34056772&form=6&db=m Salidroside protects cardiac function in mice with diabetic cardiomyopathy via activation of mitochondrial biogenesis and SIRT3. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21949662&form=6&db=m Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty (fa/fa) rats: a model of type 2 diabetes. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25192797&form=6&db=m Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-?1 in rat glomerular messangial cells. therapeutic application,unassigned 1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25301743&form=6&db=m Selenium nanoparticles involve HSP-70 and SIRT1 in preventing the progression of type 1 diabetic nephropathy. therapeutic application,unassigned 1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25375034&form=6&db=m AGEs-RAGE system down-regulates Sirt1 through the ubiquitin-proteasome pathway to promote FN and TGF-?1 expression in male rat glomerular mesangial cells. therapeutic application,unassigned 1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27773814&form=6&db=m Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells. causal interaction,unassigned 1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28986066&form=6&db=m The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-?1 expressions in rat glomerular mesangial cells. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30859351&form=6&db=m Novel tubular-glomerular interplay in diabetic kidney disease mediated by sirtuin 1, nicotinamide mononucleotide, and nicotinamide adenine dinucleotide Oshima Award Address 2017. therapeutic application,unassigned 1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31631065&form=6&db=m Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating SIRT1 expression. causal interaction,unassigned 1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31680596&form=6&db=m Sirt3 overexpression alleviates hyperglycemia-induced vascular inflammation through regulating redox balance, cell survival, and AMPK-mediated mitochondrial homeostasis. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32705273&form=6&db=m Inhibition of miRNA?135a?5p ameliorates TGF??1?induced human renal fibrosis by targeting SIRT1 in diabetic nephropathy. ongoing research,unassigned 1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33047279&form=6&db=m The effect of tropisetron on oxidative stress, SIRT1, FOXO3a, and claudin-1 in the renal tissue of STZ-induced diabetic rats. causal interaction,unassigned 1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33279869&form=6&db=m Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-?B and STAT3. therapeutic application,unassigned 1,0 2.3.1.286 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28528294&form=6&db=m Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31754701&form=6&db=m Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33186087&form=6&db=m Biomarkers in diabetic neuropathy. diagnostic usage,therapeutic application,unassigned 1,1,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26583059&form=6&db=m PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners. therapeutic application,unassigned 1,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30572719&form=6&db=m Differential expressions of SIRT1, SIRT3, and SIRT4 in peripheral blood mononuclear cells from patients with type 2 diabetic retinopathy. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31136205&form=6&db=m Cross-Talk between Sirtuin 1 and the Proinflammatory Mediator High-Mobility Group Box-1 in the Regulation of Blood-Retinal Barrier Breakdown in Diabetic Retinopathy. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32415512&form=6&db=m CircRNA cPWWP2A: an emerging player in diabetes mellitus. therapeutic application,unassigned 1,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32633335&form=6&db=m MiR-204 inhibits inflammation and cell apoptosis in retinopathy rats with diabetic retinopathy by regulating Bcl-2 and SIRT1 expressions. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32776826&form=6&db=m Overexpression of histone deacetylase SIRT1 exerts an anti-angiogenic role in diabetic retinopathy via miR-20a elevation and YAP/HIF1?/VEGFA depletion. therapeutic application,unassigned 1,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34313929&form=6&db=m MicroRNA-93-5p participates in type 2 diabetic retinopathy through targeting Sirt1. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Dry Eye Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26261685&form=6&db=m Expression of SIRT1 and oxidative stress in diabetic dry eye. ongoing research,unassigned 1,0 2.3.1.286 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28939414&form=6&db=m Role of the epigenetic factor Sirt7 in neuroinflammation and neurogenesis. causal interaction,unassigned 1,0 2.3.1.286 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29153609&form=6&db=m Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients. causal interaction,diagnostic usage,unassigned 1,4,0 2.3.1.286 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32802267&form=6&db=m Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29153609&form=6&db=m Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients. causal interaction,diagnostic usage,unassigned 1,4,0 2.3.1.286 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32802267&form=6&db=m Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 End Stage Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32334029&form=6&db=m SIRT1 activation by resveratrol reverses atrophy of apical dendrites of hippocampal CA1 pyramidal neurons and neurobehavioral impairments in moderate grade hepatic encephalopathy rats. ongoing research,unassigned 1,0 2.3.1.286 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22780949&form=6&db=m Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33438275&form=6&db=m Sirtuin 1 promotes autophagy and proliferation of endometrial cancer cells by reducing acetylation level of LC3. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24320086&form=6&db=m Resveratrol suppresses inflammatory responses in endometrial stromal cells derived from endometriosis: A possible role of the sirtuin 1 pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.3.1.286 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31906251&form=6&db=m Granulosa-Lutein Cell Sirtuin Gene Expression Profiles Differ between Normal Donors and Infertile Women. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32782715&form=6&db=m miR-9-5p promotes the invasion and migration of endometrial stromal cells in endometriosis patients through the SIRT1/NF-?B pathway. causal interaction,diagnostic usage,unassigned 1,2,0 2.3.1.286 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26522327&form=6&db=m Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31849939&form=6&db=m Dual Deletion of the Sirtuins SIRT2 and SIRT3 Impacts on Metabolism and Inflammatory Responses of Macrophages and Protects From Endotoxemia. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33049408&form=6&db=m Moderate SIRT1 overexpression protects against brown adipose tissue inflammation. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Enterocolitis, Necrotizing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34162151&form=6&db=m Melatonin-induced lncRNA LINC01512 prevents Treg/Th17 imbalance by promoting SIRT1 expression in necrotizing enterocolitis. therapeutic application,unassigned 1,0 2.3.1.286 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28197553&form=6&db=m The Role of Sirt1 in Epileptogenesis. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Epiretinal Membrane http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31136205&form=6&db=m Cross-Talk between Sirtuin 1 and the Proinflammatory Mediator High-Mobility Group Box-1 in the Regulation of Blood-Retinal Barrier Breakdown in Diabetic Retinopathy. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34475980&form=6&db=m Rapamycin suppresses the PI3K/AKT/mTOR signaling pathway by targeting SIRT1 in esophageal cancer. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25227106&form=6&db=m Effects of downregulation of SIRT3 expression on proliferation and apoptosis in esophageal squamous cell carcinoma EC9706 cells and its molecular mechanisms. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32213137&form=6&db=m Letter by Zhou et al Regarding Article, "Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress". causal interaction,unassigned 1,0 2.3.1.286 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26046330&form=6&db=m The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20595232&form=6&db=m Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20817729&form=6&db=m SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,3,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21386135&form=6&db=m Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24073959&form=6&db=m Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet. therapeutic application,unassigned 1,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25798066&form=6&db=m Stem cell transplantation upregulates Sirt1 and antioxidant expression, ameliorating fatty liver in type 2 diabetic mice. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26539534&form=6&db=m PPAR? Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury. ongoing research,unassigned 1,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28592311&form=6&db=m The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28667519&form=6&db=m Retinoic acid ameliorates high-fat diet-induced liver steatosis through sirt1. therapeutic application,unassigned 1,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28808418&form=6&db=m Emerging roles of SIRT1 in fatty liver diseases. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29595075&form=6&db=m Epigallocatechin-3-Gallate-Rich Green Tea Extract Ameliorates Fatty Liver and Weight Gain in Mice Fed a High Fat Diet by Activating the Sirtuin 1 and AMP Activating Protein Kinase Pathway. therapeutic application,unassigned 1,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29681936&form=6&db=m Metformin Regulating miR-34a Pathway to Inhibit Egr1 in Rat Mesangial Cells Cultured with High Glucose. causal interaction,unassigned 1,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29696666&form=6&db=m Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease. therapeutic application,unassigned 1,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29845302&form=6&db=m SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF??B pathway in mouse kupffer cells. diagnostic usage,ongoing research,unassigned 1,1,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30381838&form=6&db=m SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30868489&form=6&db=m Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31195981&form=6&db=m miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32520409&form=6&db=m Sirtuin 3-mediated deacetylation of acyl-CoA synthetase family member 3 by protocatechuic acid attenuates non-alcoholic fatty liver disease. therapeutic application,unassigned 1,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33202604&form=6&db=m Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,1 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33636024&form=6&db=m Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4?. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34483906&form=6&db=m Metformin Alleviates Steatohepatitis in Diet-Induced Obese Mice in a SIRT1-Dependent Way. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Fatty Liver, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18287356&form=6&db=m Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice. therapeutic application,unassigned 1,0 2.3.1.286 Fetal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26896748&form=6&db=m High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Fibromatosis, Aggressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32655835&form=6&db=m The role of miRNA-133b and its target gene SIRT1 in FAP-derived desmoid tumor. ongoing research,unassigned 1,0 2.3.1.286 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21238464&form=6&db=m Resveratrol with antioxidant activity inhibits matrix metalloproteinase via modulation of SIRT1 in human fibrosarcoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22968147&form=6&db=m Activation of SIRT1 protects pancreatic ?-cells against palmitate-induced dysfunction. therapeutic application,unassigned 1,0 2.3.1.286 Fragile X Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18369442&form=6&db=m SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome. therapeutic application,unassigned 1,0 2.3.1.286 Fragile X Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19750026&form=6&db=m Can Sir(2) regulate cancer? ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Gallbladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33872694&form=6&db=m SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28977971&form=6&db=m Meta-analysis of SIRT1 expression as a prognostic marker for overall survival in gastrointestinal cancer. causal interaction,diagnostic usage,unassigned 1,4,0 2.3.1.286 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28197299&form=6&db=m Sirtuins Expression and Their Role in Retinal Diseases. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24939540&form=6&db=m [SIRT2, a multi-talented deacetylase]. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25250818&form=6&db=m Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31207928&form=6&db=m Melatonin Modulates the Microenvironment of Glioblastoma Multiforme by Targeting Sirtuin 1. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19282667&form=6&db=m SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,3,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23522375&form=6&db=m Ultrasound-sensitive siRNA-loaded nanobubbles formed by hetero-assembly of polymeric micelles and liposomes and their therapeutic effect in gliomas. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25216517&form=6&db=m CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression. ongoing research,unassigned 1,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27270321&form=6&db=m Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27698888&form=6&db=m miRNA regulation of Sirtuin-1 expression in human astrocytoma. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28554130&form=6&db=m Betulinic acid derivative B10 inhibits glioma cell proliferation through suppression of SIRT1, acetylation of FOXO3a and upregulation of Bim/PUMA. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29756546&form=6&db=m Sinomenine Induces G1-Phase Cell Cycle Arrest and Apoptosis in Malignant Glioma Cells Via Downregulation of Sirtuin 1 and Induction of p53 Acetylation. causal interaction,unassigned 1,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31207928&form=6&db=m Melatonin Modulates the Microenvironment of Glioblastoma Multiforme by Targeting Sirtuin 1. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31319814&form=6&db=m Sirtuin1 activator SRT2183 suppresses glioma cell growth involving activation of endoplasmic reticulum stress pathway. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32896523&form=6&db=m Knockdown of circ0082374 inhibits cell viability, migration, invasion and glycolysis in glioma cells by miR-326/SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29782856&form=6&db=m Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25159328&form=6&db=m High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.3.1.286 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25190816&form=6&db=m Up-regulation of the Sirtuin 1 (Sirt1) and peroxisome proliferator-activated receptor ? coactivator-1? (PGC-1?) genes in white adipose tissue of Id1 protein-deficient mice: implications in the protection against diet and age-induced glucose intolerance. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.3.1.286 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27058248&form=6&db=m Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29296001&form=6&db=m Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30381838&form=6&db=m SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.286 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32853529&form=6&db=m Short-term effects induced by nicotinamide in ovariectomized females. therapeutic application,unassigned 1,0 2.3.1.286 Glucose Metabolism Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26201784&form=6&db=m Inhibition of silent information regulator 1 induces glucose metabolism disorders of hepatocytes and enhances hepatitis C virus replication. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 2.3.1.286 Graft vs Host Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30124203&form=6&db=m [SIRT1 deficiency in CD4+T cells induces acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation]. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 2.3.1.286 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21111225&form=6&db=m SIRT3 in calorie restriction: can you hear me now? ongoing research,unassigned 1,0 2.3.1.286 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21879450&form=6&db=m Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation. therapeutic application,unassigned 1,0 2.3.1.286 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33900547&form=6&db=m Roles of Bak and Sirt3 in Paraquat-Induced Cochlear Hair Cell Damage. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20685942&form=6&db=m Mitochondrial SIRT3 and heart disease. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22498017&form=6&db=m Protection of the heart against ischemia/reperfusion by silent information regulator 1. causal interaction,unassigned 1,0 2.3.1.286 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24073959&form=6&db=m Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet. therapeutic application,unassigned 1,0 2.3.1.286 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25815111&form=6&db=m SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.3.1.286 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30091830&form=6&db=m Sirtuin3 protects aged human mesenchymal stem cells against oxidative stress and enhances efficacy of cell therapy for ischaemic heart diseases. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.3.1.286 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30131726&form=6&db=m Acetylation of Mitochondrial Proteins in the Heart: The Role of SIRT3. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24889822&form=6&db=m Resveratrol-enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24913149&form=6&db=m Downregulation of Sirt1 as aging change in advanced heart failure. causal interaction,diagnostic usage,unassigned 1,4,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27157055&form=6&db=m Sirtuin1 Regulates the Stem Cell Therapeutic Effects on Regenerative Capability for Treating Severe Heart Failure in a Juvenile Animal Model. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31170043&form=6&db=m Correction to: Role of SIRT1 in Modulating Acetylation of the Sarco- Endoplasmic Reticulum Ca2+-ATPase in Heart Failure. causal interaction,unassigned 1,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32468895&form=6&db=m Endothelial Sirtuin 3 Dictates Glucose Transport to Cardiomyocyte and Sensitizes Pressure Overload-Induced Heart Failure. ongoing research,unassigned 1,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33576462&form=6&db=m MicroRNA?138?5p drives the progression of heart failure via inhibiting sirtuin 1 signaling. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34130840&form=6&db=m Application of a real-ambient fine particulate matter exposure system on different animal models. causal interaction,unassigned 1,0 2.3.1.286 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27232755&form=6&db=m Autophagy maintains ubiquitination-proteasomal degradation of Sirt3 to limit oxidative stress in K562 leukemia cells. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Hepatic Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32334029&form=6&db=m SIRT1 activation by resveratrol reverses atrophy of apical dendrites of hippocampal CA1 pyramidal neurons and neurobehavioral impairments in moderate grade hepatic encephalopathy rats. ongoing research,unassigned 1,0 2.3.1.286 Hepatic Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33522075&form=6&db=m Sirtuin-3 activation by honokiol restores mitochondrial dysfunction in the hippocampus of the hepatic encephalopathy rat model of ammonia neurotoxicity. ongoing research,unassigned 1,0 2.3.1.286 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25736100&form=6&db=m Suppression of SIRT1 activity in noncancerous tissues of HCC: possible association with non-B non-C hepatitis pathogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.3.1.286 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26660162&form=6&db=m The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,4 2.3.1.286 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32446392&form=6&db=m SIRT1 enhances hepatitis virus B transcription independent of hepatic autophagy. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32535108&form=6&db=m Aryl hydrocarbon receptor (AHR) functions: Balancing opposing processes including inflammatory reactions. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26660162&form=6&db=m The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,4 2.3.1.286 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28242208&form=6&db=m Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription. causal interaction,diagnostic usage,unassigned 1,1,0 2.3.1.286 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28881735&form=6&db=m Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 2.3.1.286 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29624717&form=6&db=m SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3-9 homolog 1 and SET domain containing 1A histone methyltransferases. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Hepatitis, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27669435&form=6&db=m The interaction between acetylation and serine-574 phosphorylation regulates the apoptotic function of FOXO3. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24390595&form=6&db=m Resveratrol Improves the Mitochondrial Function and Fertilization Outcome of Bovine Oocytes. ongoing research,unassigned 1,0 2.3.1.286 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32039484&form=6&db=m A novel role of SIRT2 in regulating gap junction communications via connexin-43 in bovine cumulus-oocyte complexes. causal interaction,unassigned 1,0 2.3.1.286 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18329615&form=6&db=m Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. therapeutic application,unassigned 1,0 2.3.1.286 HIV-Associated Lipodystrophy Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32106282&form=6&db=m Investigation of SIRT1 gene variants in HIV-associated lipodystrophy and metabolic syndrome. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16766037&form=6&db=m Resveratrol--a boon for treating Alzheimer's disease? therapeutic application,unassigned 1,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21370928&form=6&db=m A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22511966&form=6&db=m SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo. therapeutic application,unassigned 1,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23200855&form=6&db=m The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23417962&form=6&db=m SIRT1 and SIRT2: emerging targets in neurodegeneration. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25574479&form=6&db=m Sirtuin 1 activator SRT2104 protects Huntington's disease mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26919088&form=6&db=m Correction: SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice. causal interaction,unassigned 1,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27163642&form=6&db=m SIRT2 regulates insulin sensitivity in insulin resistant neuronal cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29742127&form=6&db=m Amelioration of Huntington's disease phenotypes by Beta-Lapachone is associated with increases in Sirt1 expression, CREB phosphorylation and PGC-1? deacetylation. causal interaction,unassigned 1,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33765019&form=6&db=m Correction: SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo. therapeutic application,unassigned 1,0 2.3.1.286 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31270711&form=6&db=m SIRT1 Activation Attenuates Bone Cancer Pain by Inhibiting mGluR1/5. therapeutic application,unassigned 1,0 2.3.1.286 Hyperandrogenism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32334629&form=6&db=m Decreased brain and muscle ARNT-like protein 1 expression mediated the contribution of hyperandrogenism to insulin resistance in polycystic ovary syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19549853&form=6&db=m SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25610880&form=6&db=m Sodium meta-arsenite ameliorates hyperglycemia in obese diabetic db/db mice by inhibition of hepatic gluconeogenesis. therapeutic application,unassigned 1,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25798922&form=6&db=m Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27058248&form=6&db=m Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28765962&form=6&db=m SIRT1 activation inhibits hyperglycemia-induced apoptosis by reducing oxidative stress and mitochondrial dysfunction in human endothelial cells. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29970985&form=6&db=m Sirt3 Ameliorates Oxidative Stress and Mitochondrial Dysfunction After Intracerebral Hemorrhage in Diabetic Rats. causal interaction,unassigned 1,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30144531&form=6&db=m Baicalin regulates SirT1/STAT3 pathway and restrains excessive hepatic glucose production. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30458128&form=6&db=m SIRT1 activation promotes angiogenesis in diabetic wounds by protecting endothelial cells against oxidative stress. ongoing research,unassigned 1,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30846716&form=6&db=m Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34073604&form=6&db=m Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6. therapeutic application,unassigned 1,0 2.3.1.286 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32715748&form=6&db=m Adipose depot-specific upregulation of Ucp1 or mitochondrial oxidative complex proteins are early consequences of genetic insulin reduction in mice. diagnostic usage,unassigned 1,0 2.3.1.286 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32943552&form=6&db=m Low dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia. causal interaction,unassigned 1,0 2.3.1.286 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30868489&form=6&db=m Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32462510&form=6&db=m Negative Regulation of SIRT1 by IRF9 Involved in Hyperlipidemia Acute Pancreatitis Associated with Kidney Injury. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Hyperphosphatemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32111067&form=6&db=m Sirtuin-1 and Its Relevance in Vascular Calcification. therapeutic application,unassigned 1,0 2.3.1.286 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21948987&form=6&db=m Sirtuin 1 promotes Th2 responses and airway allergy by repressing peroxisome proliferator-activated receptor-? activity in dendritic cells. ongoing research,unassigned 1,0 2.3.1.286 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33127810&form=6&db=m SIRT3 alleviates neuropathic pain by deacetylating FoxO3a in the spinal dorsal horn of diabetic model rats. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33973707&form=6&db=m Protective effect of miR-138-5p inhibition modified human mesenchymal stem cell on ovalbumin-induced allergic rhinitis and asthma syndrome. causal interaction,unassigned 1,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21514307&form=6&db=m Food restriction improves glucose and lipid metabolism through Sirt1 expression: a study using a new rat model with obesity and severe hypertension. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24352856&form=6&db=m Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25108014&form=6&db=m The TRPA1 channel is a cardiac target of mIGF-1/SIRT1 signaling. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25773007&form=6&db=m The influence of ethnicity in the association of WC, WHR, hypertension and PGC-1? (Gly482Ser), UCP2 -866 G/A and SIRT1 -1400 T/C polymorphisms with T2D in the population of Punjab. causal interaction,unassigned 1,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31189433&form=6&db=m Inhibition of Mitochondrial Oxidative Damage Improves Reendothelialization Capacity of Endothelial Progenitor Cells via SIRT3 (Sirtuin 3)-Enhanced SOD2 (Superoxide Dismutase 2) Deacetylation in Hypertension. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31749139&form=6&db=m Targeting histone acetylation in pulmonary hypertension and right ventricular hypertrophy. ongoing research,unassigned 1,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32213137&form=6&db=m Letter by Zhou et al Regarding Article, "Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress". causal interaction,unassigned 1,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32446297&form=6&db=m Anomalous AMPK-regulated angiotensin AT1R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32509148&form=6&db=m FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34239697&form=6&db=m Resveratrol Prevents Right Ventricle Dysfunction, Calcium Mishandling, and Energetic Failure via SIRT3 Stimulation in Pulmonary Arterial Hypertension. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32791849&form=6&db=m Endothelin-1 in portal hypertension: The intricate role of hepatic stellate cells. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29311941&form=6&db=m Sirt3 Mediates the Inhibitory Effect of Adjudin on Astrocyte Activation and Glial Scar Formation following Ischemic Stroke. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.3.1.286 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31297748&form=6&db=m Post-Stroke Microglia Induce Sirtuin2 Expression to Suppress the Anti-inflammatory Function of Infiltrating Regulatory T Cells. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32212827&form=6&db=m Neuroprotective Effects of Trilobatin, a Novel Naturally Occurring Sirt3 Agonist from Lithocarpus polystachyus Rehd., Mitigate Cerebral Ischemia/Reperfusion Injury: Involvement of TLR4/NF-?B and Nrf2/Keap-1 Signaling. therapeutic application,unassigned 1,0 2.3.1.286 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34119577&form=6&db=m Ischemia Injury induces mPTP opening by reducing Sirt3. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18800364&form=6&db=m SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation? therapeutic application,unassigned 1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19930041&form=6&db=m The contribution of Toll-like receptor 2 to the innate recognition of a Leishmania infantum silent information regulator 2 protein. therapeutic application,unassigned 1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23760629&form=6&db=m MiR-199a-5p promotes migration and tube formation of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and eNOS. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23908241&form=6&db=m A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24950067&form=6&db=m Celecoxib sensitizes Staphylococcus aureus to antibiotics in macrophages by modulating SIRT1. ongoing research,unassigned 1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25391763&form=6&db=m Scrapie Infection in Experimental Rodents and SMB-S15 Cells Decreased the Brain Endogenous Levels and Activities of Sirt1. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26522327&form=6&db=m Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28881735&form=6&db=m Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29280055&form=6&db=m Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29624717&form=6&db=m SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3-9 homolog 1 and SET domain containing 1A histone methyltransferases. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30069485&form=6&db=m Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,1,3,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31434611&form=6&db=m microRNA-579 upregulation mediates death of human macrophages with mycobacterium tuberculosis infection. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32697192&form=6&db=m Host sirtuin 2 as an immunotherapeutic target against tuberculosis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32974218&form=6&db=m Legionella pneumophila Infection Rewires the Acanthamoeba castellanii Transcriptome, Highlighting a Class of Sirtuin Genes. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34010594&form=6&db=m Involvement of SIRT1 in amelioration of schistosomiasis-induced hepatic fibrosis by genistein. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33823364&form=6&db=m Melatonin regulates the cross-talk between autophagy and apoptosis by SIRT3 in testicular Leydig cells. therapeutic application,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17908551&form=6&db=m Silencing insulin resistance through SIRT1. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18577374&form=6&db=m Sirtuins: novel targets for metabolic disease in drug development. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18840364&form=6&db=m SirT1 gain of function increases energy efficiency and prevents diabetes in mice. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19303289&form=6&db=m Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators. causal interaction,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19549853&form=6&db=m SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20439735&form=6&db=m SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21241768&form=6&db=m Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21321189&form=6&db=m Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21873205&form=6&db=m Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21982712&form=6&db=m Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21985785&form=6&db=m Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22027215&form=6&db=m Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. causal interaction,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22562959&form=6&db=m Roles and Tissue Source of Adiponectin Involved in Lifestyle Modifications. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22780949&form=6&db=m Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23604553&form=6&db=m Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23624181&form=6&db=m Resveratrol vs. calorie restriction: Data from rodents to humans. therapeutic application,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23950036&form=6&db=m The Brain: A New Organ for the Metabolic Actions of SIRT1. ongoing research,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24003918&form=6&db=m The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing. causal interaction,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24442997&form=6&db=m CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity via SIRT1. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24612843&form=6&db=m [Rosuvastatin improves insulin sensitivity in overweight rats induced by high fat diet. Role of SIRT1 in adipose tissue.] causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24762600&form=6&db=m Metformin ameliorates insulin resistance in L6 rat skeletal muscle cells through upregulation of SIRT3. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25159328&form=6&db=m High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25233986&form=6&db=m SIRT1 gene variants are related to risk of childhood obesity. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,1 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25352008&form=6&db=m Resveratrol attenuates intermittent hypoxia-induced insulin resistance in rats: involvement of Sirtuin 1 and the phosphatidylinositol-4,5-bisphosphate 3-kinase/AKT pathway. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25798922&form=6&db=m Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25850408&form=6&db=m Resveratrol inhibits inflammation and ameliorates insulin resistant endothelial dysfunction via regulation of AMP-activated protein kinase and sirtuin 1 activities. therapeutic application,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25858853&form=6&db=m Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice. causal interaction,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25921843&form=6&db=m Metformin improves putative longevity effectors in peripheral mononuclear cells from subjects with prediabetes. A randomized controlled trial. causal interaction,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25941821&form=6&db=m Application of resveratrol in diabetes: rationale, strategies and challenges. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26236282&form=6&db=m Age-Associated Weight Gain, Leptin, and SIRT1: A Possible Role for Hypothalamic SIRT1 in the Prevention of Weight Gain and Aging through Modulation of Leptin Sensitivity. therapeutic application,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26750093&form=6&db=m Docosahexaenoic acid attenuates adipose tissue angiogenesis and insulin resistance in high fat diet-fed middle-aged mice via a sirt1-dependent mechanism. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27058248&form=6&db=m Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27163642&form=6&db=m SIRT2 regulates insulin sensitivity in insulin resistant neuronal cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27836811&form=6&db=m SIRT1-AMPK crosstalk is involved in high glucose-dependent impairment of insulin responsiveness in primary rat podocytes. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28528294&form=6&db=m Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28544355&form=6&db=m Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28592311&form=6&db=m The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29796217&form=6&db=m Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30232872&form=6&db=m [Progress of Research on Mechanism of Acupuncture for Diabetes Mellitus]. therapeutic application,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30254249&form=6&db=m Publisher Correction: Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30381838&form=6&db=m SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30442237&form=6&db=m MiR-138-5p affects insulin resistance to regulate type 2 diabetes progression through inducing autophagy in HepG2 cells by regulating SIRT1. therapeutic application,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30533032&form=6&db=m SIRT2 knockout exacerbates insulin resistance in high fat-fed mice. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30715852&form=6&db=m Bone Marrow Mesenchymal Stem Cells-Derived Exosomal MiR-29b-3p Regulates Aging-Associated Insulin Resistance. therapeutic application,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31151180&form=6&db=m Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Type 2 Diabetes Show Reduced "Stemness" through an Altered Secretome Profile, Impaired Anti-Oxidative Protection, and Mitochondrial Dynamics Deterioration. causal interaction,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31778683&form=6&db=m Molecular docking and mechanisms of fusaric acid induced mitochondrial sirtuin aberrations in glycolytically and oxidatively poised human hepatocellular carcinoma (HepG2) cells. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31935731&form=6&db=m Acupuncture Targeting SIRT1 in the Hypothalamic Arcuate Nucleus Can Improve Obesity in High-Fat-Diet-Induced Rats with Insulin Resistance via an Anorectic Effect. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32032542&form=6&db=m An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance. therapeutic application,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32253917&form=6&db=m Vitamin K2 Alleviates Insulin Resistance in Skeletal Muscle by Improving Mitochondrial Function Via SIRT1 Signaling. causal interaction,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32280711&form=6&db=m N1-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32334629&form=6&db=m Decreased brain and muscle ARNT-like protein 1 expression mediated the contribution of hyperandrogenism to insulin resistance in polycystic ovary syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32758058&form=6&db=m Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32888948&form=6&db=m The effect of aerobic, resistance, and combined training on PPAR-?, SIRT1 gene expression, and insulin resistance in high-fat diet-induced NAFLD male rats. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32943552&form=6&db=m Low dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia. causal interaction,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33049408&form=6&db=m Moderate SIRT1 overexpression protects against brown adipose tissue inflammation. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33164543&form=6&db=m The probable role of insulin resistance and SIRT1 proteins in the Alzheimer's disease. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33363647&form=6&db=m ELECTROACUPUNCTURE IMPROVES INSULIN SENSITIVITY IN HIGH-FAT DIET-INDUCED INSULIN RESISTANT RATS BY ACTIVATING SIRT1 AND GLUT4 IN QUADRICEPS FEMORIS. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33636024&form=6&db=m Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4?. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33639916&form=6&db=m Relationship between insulin sensitivity and gene expression in human skeletal muscle. causal interaction,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33668369&form=6&db=m Sirt1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34063079&form=6&db=m Skeletal Muscle Gene Expression Profile in Response to Caloric Restriction and Aging: A Role for SirT1. therapeutic application,unassigned 1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34073604&form=6&db=m Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6. therapeutic application,unassigned 1,0 2.3.1.286 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18369442&form=6&db=m SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome. therapeutic application,unassigned 1,0 2.3.1.286 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19750026&form=6&db=m Can Sir(2) regulate cancer? ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27207584&form=6&db=m MiR-138-5p promotes TNF-?-induced apoptosis in human intervertebral disc degeneration by targeting SIRT1 through PTEN/PI3K/Akt signaling. ongoing research,unassigned 1,0 2.3.1.286 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32572902&form=6&db=m Sirt1 suppresses MCP-1 production during the intervertebral disc degeneration by inactivating AP-1 subunits c-Fos/c-Jun. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33565085&form=6&db=m SIRT3 mitigates intervertebral disc degeneration by delaying oxidative stress-induced senescence of nucleus pulposus cells. ongoing research,unassigned 1,0 2.3.1.286 Iron Overload http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34287090&form=6&db=m PPAR? agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and ?-catenin signaling. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19288225&form=6&db=m Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23723308&form=6&db=m Silent information regulator 1 protects the brain against cerebral ischemic damage. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28888980&form=6&db=m Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29311941&form=6&db=m Sirt3 Mediates the Inhibitory Effect of Adjudin on Astrocyte Activation and Glial Scar Formation following Ischemic Stroke. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31729962&form=6&db=m PPAR-? promotes p38 MAP kinase-mediated endothelial cell permeability through activating Sirt3. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32212827&form=6&db=m Neuroprotective Effects of Trilobatin, a Novel Naturally Occurring Sirt3 Agonist from Lithocarpus polystachyus Rehd., Mitigate Cerebral Ischemia/Reperfusion Injury: Involvement of TLR4/NF-?B and Nrf2/Keap-1 Signaling. therapeutic application,unassigned 1,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32676579&form=6&db=m Muscle-specific sirtuin1 gain-of-function ameliorates skeletal muscle atrophy in a pre-clinical mouse model of cerebral ischemic stroke. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33603645&form=6&db=m The Anti-apoptosis Effect of Single Electroacupuncture Treatment via Suppressing Neuronal Autophagy in the Acute Stage of Ischemic Stroke Without Infarct Alleviation. diagnostic usage,unassigned 1,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34119577&form=6&db=m Ischemia Injury induces mPTP opening by reducing Sirt3. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Kidney Calculi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30925129&form=6&db=m Re: SIRT3 Inhibited the Formation of Calcium Oxalate-Induced Kidney Stones through Regulating NRF2/HO-1 Signaling Pathway. therapeutic application,unassigned 1,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21664458&form=6&db=m SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27255945&form=6&db=m Up-Regulation of SIRT1 Reduces Endoplasmic Reticulum Stress and Renal Fibrosis. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27536685&form=6&db=m SIRT1 and Kidney Function. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Legionnaires' Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32974218&form=6&db=m Legionella pneumophila Infection Rewires the Acanthamoeba castellanii Transcriptome, Highlighting a Class of Sirtuin Genes. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12006491&form=6&db=m Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21807113&form=6&db=m Sirt1 deacetylates c-Myc and promotes c-Myc/Max association. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23460888&form=6&db=m Inhibition of the NAD-Dependent Protein Deacetylase SIRT2 Induces Granulocytic Differentiation in Human Leukemia Cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24223102&form=6&db=m Correction: Inhibition of the NAD-Dependent Protein Deacetylase SIRT2 Induces Granulocytic Differentiation in Human Leukemia Cells. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25822366&form=6&db=m DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,3 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26794150&form=6&db=m Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-Cell Chronic Lymphocytic Leukemia (CLL). causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27232755&form=6&db=m Autophagy maintains ubiquitination-proteasomal degradation of Sirt3 to limit oxidative stress in K562 leukemia cells. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32895473&form=6&db=m Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28043832&form=6&db=m Exosomal miR-486 regulates hypoxia-induced erythroid differentiation of erythroleukemia cells through targeting Sirt1. therapeutic application,unassigned 1,0 2.3.1.286 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26794150&form=6&db=m Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-Cell Chronic Lymphocytic Leukemia (CLL). causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.3.1.286 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24579733&form=6&db=m Sirtuins in hematological aging and malignancy. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25449787&form=6&db=m Divalproex sodium enhances the anti-leukemic effects of imatinib in chronic myeloid leukemia cells partly through SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.3.1.286 Leukemia, Promyelocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23460888&form=6&db=m Inhibition of the NAD-Dependent Protein Deacetylase SIRT2 Induces Granulocytic Differentiation in Human Leukemia Cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.3.1.286 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26063426&form=6&db=m SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 Transcription. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Leukemia-Lymphoma, Adult T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30273928&form=6&db=m KU70 Inhibition Impairs Both Non-Homologous End Joining and Homologous Recombination DNA Damage Repair Through SHP-1 Induced Dephosphorylation of SIRT1 in Adult T-Cell Leukemia-Lymphoma Cells. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Lipid Metabolism Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23480676&form=6&db=m Silent information regulator 1 inhibition induces lipid metabolism disorders of hepatocytes and enhances hepatitis C virus replication. causal interaction,diagnostic usage,unassigned 1,3,0 2.3.1.286 Lipodystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32106282&form=6&db=m Investigation of SIRT1 gene variants in HIV-associated lipodystrophy and metabolic syndrome. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27323886&form=6&db=m Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27387128&form=6&db=m Activation of the miR-34a/SIRT1/p53 Signaling Pathway Contributes to the Progress of Liver Fibrosis via Inducing Apoptosis in Hepatocytes but Not in HSCs. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27461716&form=6&db=m Corrigendum: Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29106960&form=6&db=m Carnosol-mediated Sirtuin 1 activation inhibits Enhancer of Zeste Homolog 2 to attenuate liver fibrosis. therapeutic application,unassigned 1,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30928408&form=6&db=m Nicotinamide riboside protects against liver fibrosis induced by CCl4 via regulating the acetylation of Smads signaling pathway. ongoing research,unassigned 1,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31533364&form=6&db=m PKC? Mediates NF-?B Inflammatory Response and Downregulates SIRT1 Expression in Liver Fibrosis. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31677501&form=6&db=m Ampelopsin attenuates carbon tetrachloride-induced mouse liver fibrosis and hepatic stellate cell activation associated with the SIRT1/TGF-?1/Smad3 and autophagy pathway. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31742890&form=6&db=m Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling. therapeutic application,unassigned 1,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32044992&form=6&db=m Downregulated long non-coding RNA LINC01093 in liver fibrosis promotes hepatocyte apoptosis via increasing ubiquitination of SIRT1. causal interaction,unassigned 1,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32905600&form=6&db=m Downregulated long non-coding RNA LINC01093 in liver fibrosis promotes hepatocyte apoptosis via increasing ubiquitination of SIRT1. causal interaction,unassigned 1,0 2.3.1.286 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32193100&form=6&db=m Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-?B signaling pathway. causal interaction,diagnostic usage,unassigned 1,2,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18793633&form=6&db=m Sirt1 is involved in energy metabolism: the role of chronic ethanol feeding and resveratrol. therapeutic application,unassigned 1,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21638299&form=6&db=m The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22628222&form=6&db=m Hepatoprotection of Berberine Against Hydrogen Peroxide-induced Apoptosis by Upregulation of Sirtuin 1. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27387128&form=6&db=m Activation of the miR-34a/SIRT1/p53 Signaling Pathway Contributes to the Progress of Liver Fibrosis via Inducing Apoptosis in Hepatocytes but Not in HSCs. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28534819&form=6&db=m Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK. therapeutic application,unassigned 1,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28808418&form=6&db=m Emerging roles of SIRT1 in fatty liver diseases. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29696666&form=6&db=m Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease. therapeutic application,unassigned 1,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29845302&form=6&db=m SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF??B pathway in mouse kupffer cells. diagnostic usage,ongoing research,unassigned 1,1,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30381838&form=6&db=m SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30580553&form=6&db=m n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review. ongoing research,unassigned 1,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30868489&form=6&db=m Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31160717&form=6&db=m SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31195981&form=6&db=m miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31216096&form=6&db=m Protective effect of autologous transplantation of resveratrol preconditioned adipose-derived stem cells in the treatment of diabetic liver dysfunction in rat model. causal interaction,unassigned 1,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32158242&form=6&db=m DHA Protects Against Hepatic Steatosis by Activating Sirt1 in a High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mouse Model. therapeutic application,unassigned 1,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32520409&form=6&db=m Sirtuin 3-mediated deacetylation of acyl-CoA synthetase family member 3 by protocatechuic acid attenuates non-alcoholic fatty liver disease. therapeutic application,unassigned 1,0 2.3.1.286 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30580553&form=6&db=m n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review. ongoing research,unassigned 1,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22728651&form=6&db=m AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25736100&form=6&db=m Suppression of SIRT1 activity in noncancerous tissues of HCC: possible association with non-B non-C hepatitis pathogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30569158&form=6&db=m MicroRNA?486?5p functions as a tumor suppressor of proliferation and cancer stem?like cell properties by targeting Sirt1 in liver cancer. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30579120&form=6&db=m The photodynamic activity and toxicity evaluation of 5,10,15-tris(ethoxylcarbonyl)corrole phosphorus(V) in vivo and in vitro. ongoing research,unassigned 1,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31394122&form=6&db=m Deacetylation of ?-catenin by SIRT1 regulates self-renewal and oncogenesis of liver cancer stem cells. ongoing research,unassigned 1,0 2.3.1.286 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31299012&form=6&db=m Ambient particulate matter attenuates Sirtuin1 and augments SREBP1-PIR axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25909427&form=6&db=m SIRT1 mediates a primed response to immune challenge after traumatic lung injury. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25940282&form=6&db=m [Resveratrol inhibits hyperxia-induced cell apoptosis through up-regulating SIRT1 expression in HPAECs]. therapeutic application,unassigned 1,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30901738&form=6&db=m The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-?B acetylation. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32020692&form=6&db=m Resveratrol protects the integrity of alveolar epithelial barrier via SIRT1/PTEN/p-Akt pathway in methamphetamine-induced chronic lung injury. diagnostic usage,ongoing research,unassigned 1,1,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33207945&form=6&db=m MicroRNA-217 modulates inflammation, oxidative stress, and lung injury in septic mice via SIRT1. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33260147&form=6&db=m Propofol reduces renal ischemia/reperfusion-induced acute lung injury by stimulating sirtuin 1 and inhibiting pyroptosis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33362546&form=6&db=m Melatonin Attenuates Sepsis-Induced Acute Lung Injury Through Improvement of Epithelial Sodium Channel-Mediated Alveolar Fluid Clearance Via Activation of SIRT1/SGK1/Nedd4-2 Signaling Pathway. causal interaction,unassigned 1,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33481000&form=6&db=m Silent information regulator type-1 mediates amelioration of inflammatory response and oxidative stress in lipopolysaccharide-induced acute respiratory distress syndrome. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29552768&form=6&db=m The expression and mechanism of Sirt1 and AMPK in nonsmall cell lung cancer. ongoing research,unassigned 1,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31377334&form=6&db=m miRNAs deregulation in serum of mice is associated with lung cancer related pathway deregulation induced by PM2.5. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32151067&form=6&db=m Ginsenoside Rp1, A Ginsenoside Derivative, Augments Anti-Cancer Effects of Actinomycin D via Downregulation of an AKT-SIRT1 Pathway. ongoing research,unassigned 1,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32229158&form=6&db=m SIRT3 increases cisplatin sensitivity of small-cell lung cancer through apoptosis. therapeutic application,unassigned 1,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32319822&form=6&db=m Long Noncoding RNA SNHG10 Sponges miR-543 to Upregulate Tumor Suppressive SIRT1 in Nonsmall Cell Lung Cancer. causal interaction,unassigned 1,0 2.3.1.286 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28324774&form=6&db=m Methylation changes of SIRT1, KLF4, DAPK1 and SPG20 in B-lymphocytes derived from follicular and diffuse large B-cell lymphoma. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25323330&form=6&db=m Protective effects of icariin-mediated SIRT1/FOXO3 signaling pathway on intestinal ischemia/reperfusion-induced acute lung injury. therapeutic application,unassigned 1,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28324774&form=6&db=m Methylation changes of SIRT1, KLF4, DAPK1 and SPG20 in B-lymphocytes derived from follicular and diffuse large B-cell lymphoma. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29805682&form=6&db=m Tremella polysaccharides inhibit cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide in A549 cells through sirtuin 1 activation. causal interaction,unassigned 1,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30029514&form=6&db=m Comparison of the Effect of Melatonin Treatment before and after Brain Ischemic Injury in the Inflammatory and Apoptotic Response in Aged Rats. therapeutic application,unassigned 1,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32633335&form=6&db=m MiR-204 inhibits inflammation and cell apoptosis in retinopathy rats with diabetic retinopathy by regulating Bcl-2 and SIRT1 expressions. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33373933&form=6&db=m Fibronectin protected bovine preantral follicles from the deleterious effects of kisspeptin. causal interaction,diagnostic usage,unassigned 1,2,0 2.3.1.286 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28324774&form=6&db=m Methylation changes of SIRT1, KLF4, DAPK1 and SPG20 in B-lymphocytes derived from follicular and diffuse large B-cell lymphoma. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Lymphoma, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33273692&form=6&db=m A C21-steroidal derivative suppresses T-cell lymphoma in mice by inhibiting SIRT3 via SAP18-SIN3. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26174951&form=6&db=m SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26656366&form=6&db=m Single Nucleotide Polymorphisms of the Sirtuin 1 (SIRT1) Gene are Associated With age-Related Macular Degeneration in Chinese Han Individuals: A Case-Control Pilot Study. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28197299&form=6&db=m Sirtuins Expression and Their Role in Retinal Diseases. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17935109&form=6&db=m Next issue (November 2007): Singapore Biotech Crossroads. therapeutic application,unassigned 1,0 2.3.1.286 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23443558&form=6&db=m Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22228742&form=6&db=m Variants in the SIRT1 gene may affect diabetes risk in interaction with prenatal exposure to famine. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24363451&form=6&db=m Determinants of GH resistance in malnutrition. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 2.3.1.286 Massive Hepatic Necrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33678756&form=6&db=m The sirtuin 1 activator SRT1720 alleviated endotoxin-induced fulminant hepatitis in mice. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25250818&form=6&db=m Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25912555&form=6&db=m AC-93253 triggers the downregulation of melanoma progression markers and the inhibition of melanoma cell proliferation. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29374154&form=6&db=m SIRT1 induces epithelial-mesenchymal transition by promoting autophagic degradation of E-cadherin in melanoma cells. ongoing research,unassigned 1,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29383100&form=6&db=m SIRT1 regulates Mxd1 during malignant melanoma progression. therapeutic application,unassigned 1,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31091806&form=6&db=m SIRT2 Contributes to the Resistance of Melanoma Cells to the Multikinase Inhibitor Dasatinib. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32636443&form=6&db=m Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for ?-catenin or MITF in colon cancer and melanoma cells. therapeutic application,unassigned 1,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33028392&form=6&db=m Nicotinamide inhibits melanoma in vitro and in vivo. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33274232&form=6&db=m MicroRNA-148b Inhibits the Malignant Biological Behavior of Melanoma by Reducing Sirtuin 7 Expression Levels. diagnostic usage,therapeutic application,unassigned 1,1,0 2.3.1.286 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29319388&form=6&db=m Woohwangcheongsimwon Prevents High-Fat Diet-Induced Memory Deficits and Induces SIRT1 in Mice. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32353801&form=6&db=m Kaempferol protects against cadmium chloride-induced hippocampal damage and memory deficits by activation of silent information regulator 1 and inhibition of poly (ADP-Ribose) polymerase-1. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23301673&form=6&db=m PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1. causal interaction,unassigned 1,0 2.3.1.286 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26885609&form=6&db=m SIRT1 at the crossroads of AKT1 and ER? in malignant pleural mesothelioma cells. ongoing research,unassigned 1,0 2.3.1.286 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26885609&form=6&db=m SIRT1 at the crossroads of AKT1 and ER? in malignant pleural mesothelioma cells. ongoing research,unassigned 1,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17112576&form=6&db=m Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19075764&form=6&db=m Sirtuin modulators: targets for metabolic diseases and beyond. therapeutic application,unassigned 1,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20872319&form=6&db=m Sirtuin-targeting drugs: Mechanisms of action and potential therapeutic applications. therapeutic application,unassigned 1,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21345154&form=6&db=m Sirtuin 1 in lipid metabolism and obesity. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22682224&form=6&db=m The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. ongoing research,unassigned 1,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22704089&form=6&db=m Continuous multiparametric monitoring of cell metabolism in response to transient overexpression of the sirtuin deacetylase SIRT3. diagnostic usage,unassigned 1,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23185430&form=6&db=m A molecular mechanism for direct sirtuin activation by resveratrol. therapeutic application,unassigned 1,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24073959&form=6&db=m Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet. therapeutic application,unassigned 1,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26463981&form=6&db=m The sirtuins: Markers of metabolic health. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26583059&form=6&db=m PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners. therapeutic application,unassigned 1,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28123512&form=6&db=m SIRT4 overexpression protects against diabetic nephropathy by inhibiting podocyte apoptosis. causal interaction,unassigned 1,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28707980&form=6&db=m Extranuclear Sirtuins and Metabolic Stress. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21040402&form=6&db=m At the Crossroads of Longevity and Metabolism: The Metabolic Syndrome and Life-Span Determinant Pathways. therapeutic application,unassigned 1,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21514307&form=6&db=m Food restriction improves glucose and lipid metabolism through Sirt1 expression: a study using a new rat model with obesity and severe hypertension. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22533670&form=6&db=m SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22939883&form=6&db=m SIRT1 in metabolic syndrome: Where to target matters. therapeutic application,unassigned 1,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25720087&form=6&db=m Natural mineral-rich water ingestion improves hepatic and fat glucocorticoid-signaling and increases sirtuin 1 in an animal model of metabolic syndrome. ongoing research,unassigned 1,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32106282&form=6&db=m Investigation of SIRT1 gene variants in HIV-associated lipodystrophy and metabolic syndrome. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32796716&form=6&db=m Sirt1-PPARS Cross-Talk in Complex Metabolic Diseases and Inherited Disorders of the One Carbon Metabolism. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34348619&form=6&db=m Metabolomic connections between schizophrenia, antipsychotic drugs and metabolic syndrome: A variety of players. causal interaction,unassigned 1,0 2.3.1.286 Mitochondrial Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23046812&form=6&db=m Regulation of mitochondrial F(o)F(1)ATPase activity by Sirt3-catalyzed deacetylation and its deficiency in human cells harboring 4977bp deletion of mitochondrial DNA. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.3.1.286 Mitochondrial Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24797412&form=6&db=m Roles of sirtuins in the regulation of antioxidant defense and bioenergetic function of mitochondria under oxidative stress. causal interaction,unassigned 1,0 2.3.1.286 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25424420&form=6&db=m Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 MPTP Poisoning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26167274&form=6&db=m Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced parkinsonism. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.286 Mucositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31497199&form=6&db=m Inhibition of SIRT1 promotes taste bud stem cell survival and mitigates radiation-induced oral mucositis in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.3.1.286 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31576013&form=6&db=m Proteasome inhibitor induced SIRT1 deacetylates GLI2 to enhance hedgehog signaling activity and drug resistance in multiple myeloma. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33861984&form=6&db=m SIRT2 and SIRT3 expression correlates with redox imbalance and advanced clinical stage in patients with multiple myeloma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 2.3.1.286 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34476507&form=6&db=m Sirtuin 2 knockdown inhibits cell proliferation and RAS/ERK signaling, and promotes cell apoptosis and cell cycle arrest in multiple myeloma. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29153609&form=6&db=m Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients. causal interaction,diagnostic usage,unassigned 1,4,0 2.3.1.286 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30028960&form=6&db=m Phosphorylated SIRT1 as a biomarker of relapse and response to treatment with glatiramer acetate in multiple sclerosis. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31610192&form=6&db=m Ellagic acid improves muscle dysfunction in cuprizone-induced demyelinated mice via mitochondrial Sirt3 regulation. ongoing research,unassigned 1,0 2.3.1.286 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32328069&form=6&db=m Histone Deacetylase SIRT1 Mediates C5b-9-Induced Cell Cycle in Oligodendrocytes. causal interaction,unassigned 1,0 2.3.1.286 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33687904&form=6&db=m Dysregulation of SIRT-1 Signaling in Multiple Sclerosis and Neuroimmune Disorders: A Systematic Review on SIRTUIN Activators as Potential Immunomodulators and Influences on other Dysfunctions. therapeutic application,unassigned 1,0 2.3.1.286 Multiple Sclerosis, Relapsing-Remitting http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30028960&form=6&db=m Phosphorylated SIRT1 as a biomarker of relapse and response to treatment with glatiramer acetate in multiple sclerosis. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Multiple System Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20849899&form=6&db=m Role of TPPP/p25 on ?-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24003218&form=6&db=m SIRT1 by blocking the activities of FoxO1 and 3 inhibits muscle atrophy and promotes muscle growth. causal interaction,unassigned 1,0 2.3.1.286 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28124088&form=6&db=m Carboxyamidotriazole alleviates muscle atrophy in tumor-bearing mice by inhibiting NF-?B and activating SIRT1. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30793539&form=6&db=m Myricanol rescues dexamethasone-induced muscle dysfunction via a sirtuin 1-dependent mechanism. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,4 2.3.1.286 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32676579&form=6&db=m Muscle-specific sirtuin1 gain-of-function ameliorates skeletal muscle atrophy in a pre-clinical mouse model of cerebral ischemic stroke. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34066110&form=6&db=m Tart Cherry (Fruit of Prunus cerasus) Concentrated Powder (TCcp) Ameliorates Glucocorticoid-Induced Muscular Atrophy in Mice. therapeutic application,unassigned 1,0 2.3.1.286 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18397876&form=6&db=m Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1. therapeutic application,unassigned 1,0 2.3.1.286 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34205021&form=6&db=m A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23024374&form=6&db=m Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress. therapeutic application,unassigned 1,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27078640&form=6&db=m Genetic and Functional Sequence Variants of the SIRT3 Gene Promoter in Myocardial Infarction. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28329314&form=6&db=m SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28445509&form=6&db=m Functional genetic variants within the SIRT2 gene promoter in acute myocardial infarction. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30050588&form=6&db=m Flavonoid Extract from Propolis Inhibits Cardiac Fibrosis Triggered by Myocardial Infarction through Upregulation of SIRT1. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30091830&form=6&db=m Sirtuin3 protects aged human mesenchymal stem cells against oxidative stress and enhances efficacy of cell therapy for ischaemic heart diseases. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30849417&form=6&db=m Cardioprotective effect of a moderate and prolonged exercise training involves sirtuin pathway. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31298401&form=6&db=m Theacrine attenuates myocardial fibrosis after myocardial infarction via the SIRT3/?-catenin/PPAR? pathway in estrogen-deficient mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,4 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31751439&form=6&db=m Euterpe Oleracea Mart. (Açaí) Reduces Oxidative Stress and Improves Energetic Metabolism in Myocardial Ischemia-Reperfusion Injury in Rats. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33079829&form=6&db=m Improvement of Cardiac Function in Rats With Myocardial Infarction by Low-Intensity to Moderate-Intensity Endurance Exercise Is Associated With Normalization of Klotho and SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34374267&form=6&db=m [Effects of aerobic interval training on myocardial oxidative stress and inflammation in rats with myocardial infarction and its mechanism]. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25877446&form=6&db=m Losartan protects the heart against ischemia reperfusion injury: sirtuin3 involvement. causal interaction,unassigned 1,0 2.3.1.286 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33307094&form=6&db=m Ubiquitin-like protein FAT10 suppresses SIRT1-mediated autophagy to protect against ischemic myocardial injury. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Myocardial Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25150882&form=6&db=m Interferon regulatory factor 9 is an essential mediator of heart dysfunction and cell death following myocardial ischemia/reperfusion injury. therapeutic application,unassigned 1,0 2.3.1.286 Myositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18922603&form=6&db=m Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 nadh:ubiquinone reductase (h+-translocating) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31655048&form=6&db=m Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25424420&form=6&db=m Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28368421&form=6&db=m Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPR(mt) to promote metastasis. causal interaction,unassigned 1,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28923398&form=6&db=m SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,2,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30250020&form=6&db=m SIRT1 suppresses the migration and invasion of gastric cancer by regulating ARHGAP5 expression. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31442917&form=6&db=m Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32442721&form=6&db=m Emerging role of sirtuins in breast cancer metastasis and multidrug resistance: Implication for novel therapeutic strategies targeting sirtuins. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12297502&form=6&db=m Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16269335&form=6&db=m Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16563646&form=6&db=m SIRT1: cellular senescence, cancer and organismal aging? therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18235501&form=6&db=m DBC1 is a negative regulator of SIRT1. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18414679&form=6&db=m The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18818524&form=6&db=m SIRT1 protein levels in cancer: tuning SIRT1 to the needs of a cancer cell. diagnostic usage,ongoing research,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19017485&form=6&db=m SIRT1: roles in aging and cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19282667&form=6&db=m SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19364925&form=6&db=m A c-Myc-SIRT1 feedback loop regulates cell growth and transformation. ongoing research,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19750026&form=6&db=m Can Sir(2) regulate cancer? ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19754813&form=6&db=m Expression and sequence of canine SIRT2 and p53 genes in canine mammary tumour cells - effects on downstream targets Wip1 and p21/Cip1. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19763917&form=6&db=m Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-X(L) and survivin. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19839049&form=6&db=m E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20004495&form=6&db=m SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20118981&form=6&db=m Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20528229&form=6&db=m Aging and cancer: are sirtuins the link? causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20577263&form=6&db=m SIRT1 stabilizes PML promoting its sumoylation. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20601279&form=6&db=m Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins). therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20620956&form=6&db=m Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20733005&form=6&db=m Stimulation of Sirt1-regulated FoxO protein function by the ligand-bound vitamin D receptor. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20872319&form=6&db=m Sirtuin-targeting drugs: Mechanisms of action and potential therapeutic applications. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20975665&form=6&db=m Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21277938&form=6&db=m Protected from the inside: endogenous histone deacetylase inhibitors and the road to cancer. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21386086&form=6&db=m The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21386135&form=6&db=m Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21471201&form=6&db=m Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent inhibition of sirtuin 1. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21801305&form=6&db=m Salermide upregulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21879450&form=6&db=m Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21957481&form=6&db=m Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21987377&form=6&db=m 75-kd sirtuin 1 blocks tumor necrosis factor ?-mediated apoptosis in human osteoarthritic chondrocytes. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22064865&form=6&db=m Interferon gamma (IFN-?) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22080944&form=6&db=m SIRT1, metabolism and cancer. diagnostic usage,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22277911&form=6&db=m Correction: Sirtuin 1 Is Upregulated in a Subset of Hepatocellular Carcinomas where It Is Essential for Telomere Maintenance and Tumor Cell Growth. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22331558&form=6&db=m A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22533670&form=6&db=m SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22622047&form=6&db=m Accelerating cancer evolution: a dark side of SIRT1 in genome maintenance. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22694102&form=6&db=m Molecular modeling study for conformational changes of Sirtuin 2 due to substrate and inhibitor binding. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22704089&form=6&db=m Continuous multiparametric monitoring of cell metabolism in response to transient overexpression of the sirtuin deacetylase SIRT3. diagnostic usage,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22704269&form=6&db=m Impact of vitamin D metabolism on clinical epigenetics. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22847743&form=6&db=m The controversial role of Sirtuins in tumorigenesis - SIRT7 joins the debate. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22982396&form=6&db=m Oncogene Ras/Phosphatidylinositol 3-kinase (PI3K) signaling targets histone H3 acetylation at lysine K56. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23050959&form=6&db=m Janus-faced role of SIRT1 in tumorigenesis. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23178529&form=6&db=m Omentin-1, a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells. ongoing research,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23224434&form=6&db=m The tumor suppressor protein menin inhibits NF-?B-mediated transactivation through recruitment of Sirt1 in hepatocellular carcinoma. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23284922&form=6&db=m Global effect of inauhzin on human p53-responsive transcriptome. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23323102&form=6&db=m Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23479127&form=6&db=m SIRT1 inhibits TNF-?-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23561972&form=6&db=m Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24020007&form=6&db=m Sirtuin-3 (SIRT3) and the Hallmarks of Cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24032643&form=6&db=m Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24040102&form=6&db=m Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24107295&form=6&db=m SIRT1 is downregulated in gastric cancer and leads to G1-phase arrest via NF-?B/Cyclin D1 signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24118446&form=6&db=m Amurensin G enhances the susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity of cancer stem-like cells of HCT-15 cells. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24137378&form=6&db=m Nicotinamide-mediated inhibition of SIRT1 deacetylase is associated with the viability of cancer cells exposed to antitumor agents and apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24241058&form=6&db=m Enhanced activation of NAD(P)H: quinone oxidoreductase 1 attenuates spontaneous hypertension by improvement of endothelial nitric oxide synthase coupling via tumor suppressor kinase liver kinase B1/adenosine 5'-monophosphate-activated protein kinase-mediated guanosine 5'-triphosphate cyclohydrolase 1 preservation. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24579733&form=6&db=m Sirtuins in hematological aging and malignancy. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24681097&form=6&db=m AROS has a context-dependent effect on SIRT1. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24819061&form=6&db=m Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24850427&form=6&db=m Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut. ongoing research,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24893986&form=6&db=m Inhibitory effect of baicalin on collagen-induced arthritis in rats through the nuclear factor-?B pathway. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24959379&form=6&db=m SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24970682&form=6&db=m Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1?/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25026276&form=6&db=m Dietary energy balance modulates ovarian cancer progression and metastasis. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25275504&form=6&db=m Further characterization of HDAC and SIRT gene expression patterns in pancreatic cancer and their relation to disease outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25323330&form=6&db=m Protective effects of icariin-mediated SIRT1/FOXO3 signaling pathway on intestinal ischemia/reperfusion-induced acute lung injury. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25341474&form=6&db=m Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain Tumors. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25347121&form=6&db=m The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25526086&form=6&db=m Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells. ongoing research,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25665036&form=6&db=m Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25672491&form=6&db=m Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25815111&form=6&db=m SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25973086&form=6&db=m High expression of Sirt7 served as a predictor of adverse outcome in breast cancer. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26024947&form=6&db=m Discovery of SIRT3 Inhibitors Using SAMDI Mass Spectrometry. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26448816&form=6&db=m Physical Training Regulates Mitochondrial Parameters and Neuroinflammatory Mechanisms in an Experimental Model of Parkinson's Disease. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26522327&form=6&db=m Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26619800&form=6&db=m HDAC4 mediates IFN-? induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26625772&form=6&db=m Down Regulation of miR-34a and miR-143 May Indirectly Inhibit p53 in Oral Squamous Cell Carcinoma: a Pilot Study. diagnostic usage,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26628989&form=6&db=m Emodin inhibits HMGB1-induced tumor angiogenesis in human osteosarcoma by regulating SIRT1. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26633734&form=6&db=m Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD(+)/NADH Ratio and SIRT1. ongoing research,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26977881&form=6&db=m A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity. causal interaction,ongoing research,therapeutic application,unassigned 1,1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27022139&form=6&db=m Role of mitochondrial dysfunction in cancer progression. causal interaction,diagnostic usage,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27072976&form=6&db=m Prognostic and clinical value of Sirt1 expression in gastric cancer: A systematic meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27085036&form=6&db=m Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27197174&form=6&db=m SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27232755&form=6&db=m Autophagy maintains ubiquitination-proteasomal degradation of Sirt3 to limit oxidative stress in K562 leukemia cells. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27270321&form=6&db=m Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27463693&form=6&db=m Macromolecular crowding effect is critical for maintaining SIRT1's nuclear localization in cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27637077&form=6&db=m SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27715462&form=6&db=m Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27748572&form=6&db=m miR-204-5p targeting SIRT1 regulates hepatocellular carcinoma progression. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27791271&form=6&db=m SirT3 and p53 Deacetylation in Aging and Cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27837177&form=6&db=m Protection of resveratrol on acute kidney injury in septic rats. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27878231&form=6&db=m SIRT1 exerts neuroprotective effects by attenuating cerebral ischemia/reperfusion-induced injury via targeting p53/microRNA-22. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27883020&form=6&db=m CHFR negatively regulates SIRT1 activity upon oxidative stress. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27935866&form=6&db=m HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs). therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28273169&form=6&db=m Reversible modulation of SIRT1 activity in a mouse strain. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28338198&form=6&db=m The expression of SIRT3 in primary hepatocellular carcinoma and the mechanism of its tumor suppressing effects. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28386046&form=6&db=m Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28507478&form=6&db=m Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28512002&form=6&db=m Cell-surface G-protein-coupled receptors for tumor-associated metabolites: A direct link to mitochondrial dysfunction in cancer. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28587858&form=6&db=m Rebamipide reduces amyloid-? 1-42 (A?42) production and ameliorates A?43-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells. ongoing research,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28592311&form=6&db=m The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28604662&form=6&db=m Upregulation of mitochondrial NAD(+) levels impairs the clonogenicity of SSEA1(+) glioblastoma tumor-initiating cells. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28765952&form=6&db=m mTOR signaling promotes foam cell formation and inhibits foam cell egress through suppressing the SIRT1 signaling pathway. diagnostic usage,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28881735&form=6&db=m Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28904318&form=6&db=m CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28923398&form=6&db=m SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28943922&form=6&db=m Obesity accelerates murine gastric cancer growth by modulating the Sirt1/YAP pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28979804&form=6&db=m Sirtuin 7 plays an oncogenic role in human osteosarcoma via downregulating CDC4 expression. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29177909&form=6&db=m Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™). therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29180469&form=6&db=m SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29344236&form=6&db=m Alterations in expression levels of genes in p53-related pathways determined using RNA-Seq analysis in patients with breast cancer following CIK therapy. diagnostic usage,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29373899&form=6&db=m Mitochondrial Effects of Teucrium Polium and Prosopis Farcta Extracts in Colorectal Cancer Cells causal interaction,diagnostic usage,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29500491&form=6&db=m Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29597027&form=6&db=m Natural products with anti-aging potential: Affected targets and molecular mechanisms. ongoing research,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29632297&form=6&db=m Baicalin, a Chinese Herbal Medicine, Inhibits the Proliferation and Migration of Human Non-Small Cell Lung Carcinoma (NSCLC) Cells, A549 and H1299, by Activating the SIRT1/AMPK Signaling Pathway. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29789426&form=6&db=m JAK1-mediated Sirt1 phosphorylation functions as a negative feedback of the JAK1-STAT3 pathway. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29845302&form=6&db=m SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF??B pathway in mouse kupffer cells. diagnostic usage,ongoing research,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29966675&form=6&db=m Melatonin improves cardiac and mitochondrial function during doxorubicin-induced cardiotoxicity: A possible role for peroxisome proliferator-activated receptor gamma coactivator 1-alpha and sirtuin activity? causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30029514&form=6&db=m Comparison of the Effect of Melatonin Treatment before and after Brain Ischemic Injury in the Inflammatory and Apoptotic Response in Aged Rats. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30092626&form=6&db=m Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30237545&form=6&db=m CPEB1 mediates hepatocellular carcinoma cancer stemness and chemoresistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30282801&form=6&db=m Sirtuin 7-mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30417353&form=6&db=m Licochalcone A attenuates abdominal aortic aneurysm induced by angiotensin II via regulating the miR-181b/SIRT1/HO-1 signaling. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30445998&form=6&db=m ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30456702&form=6&db=m Sirtuin 1 inhibits TNF-?-mediated osteoclastogenesis of bone marrow-derived macrophages through both ROS generation and TRPV1 activation. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30487699&form=6&db=m Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30496037&form=6&db=m Hypermethylated in cancer 1 (HIC1) mediates high glucose induced ROS accumulation in renal tubular epithelial cells by epigenetically repressing SIRT1 transcription. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30555597&form=6&db=m Layer-by-layer assembled gold nanoshells for the intracellular delivery of miR-34a. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30569158&form=6&db=m MicroRNA?486?5p functions as a tumor suppressor of proliferation and cancer stem?like cell properties by targeting Sirt1 in liver cancer. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30580553&form=6&db=m n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review. ongoing research,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30654820&form=6&db=m Emerging roles of telomeric chromatin alterations in cancer. ongoing research,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655868&form=6&db=m Identification of dysregulated microRNAs in canine malignant melanoma. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30739913&form=6&db=m Inhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30881341&form=6&db=m Insulin/IGF-1R, SIRT1, and FOXOs Pathways-An Intriguing Interaction Platform for Bone and Osteosarcoma. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30890607&form=6&db=m Werner Helicase Control of Human Papillomavirus 16 E1-E2 DNA Replication Is Regulated by SIRT1 Deacetylation. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30982660&form=6&db=m Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31063745&form=6&db=m SIRT1 Regulates Lysosome Function and Exosome Secretion. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31070483&form=6&db=m MiR-217 Inhibits Proliferation, Migration, and Invasion by Targeting SIRT1 in Osteosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31103492&form=6&db=m d-Limonene protects PC12 cells against corticosterone-induced neurotoxicity by activating the AMPK pathway. diagnostic usage,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31142741&form=6&db=m RelB acts as a molecular switch driving chronic inflammation in glioblastoma multiforme. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31271836&form=6&db=m Feeding restriction alleviates high carbohydrate diet-induced oxidative stress and inflammation of Megalobrama amblycephala by activating the AMPK-SIRT1 pathway. diagnostic usage,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31321634&form=6&db=m Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31357491&form=6&db=m Discovery of (5-Phenylfuran-2-yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31442917&form=6&db=m Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31638409&form=6&db=m Resveratrol inhibits high-glucose-induced inflammatory "metabolic memory" in human retinal vascular endothelial cells through SIRT1-dependent signaling. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31651733&form=6&db=m BOS Is Associated With Decreased SIRT1 in Peripheral Blood Proinflammatory T, NK, and NKT-like Lymphocytes. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31778683&form=6&db=m Molecular docking and mechanisms of fusaric acid induced mitochondrial sirtuin aberrations in glycolytically and oxidatively poised human hepatocellular carcinoma (HepG2) cells. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31812668&form=6&db=m Mutant p53 induces SIRT3/MnSOD axis to moderate ROS production in melanoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31888201&form=6&db=m Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31956359&form=6&db=m Nicotinic-nAChR signaling mediates drug resistance in lung cancer. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32051395&form=6&db=m SIRT1 inhibits chemoresistance and cancer stemness of gastric cancer by initiating an AMPK/FOXO3 positive feedback loop. diagnostic usage,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32193100&form=6&db=m Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-?B signaling pathway. causal interaction,diagnostic usage,unassigned 1,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32312920&form=6&db=m Sirt3 regulates the level of mitochondrial DNA repair activity through deacetylation of NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 in colorectal cancer. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32319822&form=6&db=m Long Noncoding RNA SNHG10 Sponges miR-543 to Upregulate Tumor Suppressive SIRT1 in Nonsmall Cell Lung Cancer. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32323786&form=6&db=m Catalpol?mediated microRNA?34a suppresses autophagy and malignancy by regulating SIRT1 in colorectal cancer. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32366480&form=6&db=m Senescent Stromal Cells Promote Cancer Resistance through SIRT1 Loss-Potentiated Overproduction of Small Extracellular Vesicles. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32373350&form=6&db=m Sirtuin 1: A Dilemma in Transplantation. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32412821&form=6&db=m Kaempferol Protects Against Hydrogen Peroxide-Induced Retinal Pigment Epithelium Cell Inflammation and Apoptosis by Activation of SIRT1 and Inhibition of PARP1. diagnostic usage,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32442721&form=6&db=m Emerging role of sirtuins in breast cancer metastasis and multidrug resistance: Implication for novel therapeutic strategies targeting sirtuins. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32586688&form=6&db=m Clinicopathological and molecular analysis of SIRT7 in hepatocellular carcinoma. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32605336&form=6&db=m Surtuin 1 as a potential prognostic biomarker in very elderly patients with colorectal cancer. diagnostic usage,therapeutic application,unassigned 1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32655835&form=6&db=m The role of miRNA-133b and its target gene SIRT1 in FAP-derived desmoid tumor. ongoing research,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32791849&form=6&db=m Endothelin-1 in portal hypertension: The intricate role of hepatic stellate cells. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32847114&form=6&db=m Resveratrol and Resveratrol-Aspirin Hybrid Compounds as Potent Intestinal Anti-Inflammatory and Anti-Tumor Drugs. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32942548&form=6&db=m Dysregulation of Key Proteins Associated with Sperm Motility and Fertility Potential in Cancer Patients. causal interaction,diagnostic usage,unassigned 1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32967053&form=6&db=m SIRT1 Gene SNP rs932658 is Associated with Medication-Related Osteonecrosis of the Jaw. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33016509&form=6&db=m ?2-AR activation promotes cleavage and nuclear translocation of Her2 and metastatic potential of cancer cells. ongoing research,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33195286&form=6&db=m RASSF1A Regulates Spindle Organization by Modulating Tubulin Acetylation via SIRT2 and HDAC6 in Mouse Oocytes. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33207824&form=6&db=m ROS-Induced SIRT2 Upregulation Contributes to Cisplatin Sensitivity in Ovarian Cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33214845&form=6&db=m Simultaneous Inhibition of SIRT2 Deacetylase and Defatty-Acylase Activities via a PROTAC Strategy. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33249095&form=6&db=m MAPK pathway and SIRT1 are involved in the down-regulation of secreted osteopontin expression by genistein in metastatic cancer cells. causal interaction,diagnostic usage,unassigned 1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33273692&form=6&db=m A C21-steroidal derivative suppresses T-cell lymphoma in mice by inhibiting SIRT3 via SAP18-SIN3. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33297189&form=6&db=m Functional benefit and molecular mechanism of vitamin C against perfluorooctanesulfonate-associated leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33316537&form=6&db=m SUMOylation is essential for Sirt2 tumor-suppressor function in neuroblastoma. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33403784&form=6&db=m CCAR1 and CCAR2 as gene chameleons with antagonistic duality: Preclinical, human translational, and mechanistic basis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33438275&form=6&db=m Sirtuin 1 promotes autophagy and proliferation of endometrial cancer cells by reducing acetylation level of LC3. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33678753&form=6&db=m Sirt7 Deficiency Attenuates Neointimal Formation Following Vascular Injury by Modulating Vascular Smooth Muscle Cell Proliferation. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33687167&form=6&db=m Evaluation of The Relationship among The Levels of SIRT1 and SIRT3 with Oxidative Stress and DNA Fragmentation in Asthenoteratozoospermic Men. causal interaction,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33789098&form=6&db=m SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33867853&form=6&db=m Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33872694&form=6&db=m SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34187277&form=6&db=m Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34355990&form=6&db=m microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials. ongoing research,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34374267&form=6&db=m [Effects of aerobic interval training on myocardial oxidative stress and inflammation in rats with myocardial infarction and its mechanism]. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34396428&form=6&db=m Ultrasound?targeted microbubble destruction?mediated overexpression of Sirtuin 3 inhibits the progression of ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34435654&form=6&db=m [Retracted] Function of miR?212 as a tumor suppressor in thyroid cancer by targeting SIRT1. therapeutic application,unassigned 1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34471236&form=6&db=m SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis. diagnostic usage,ongoing research,unassigned 1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34475980&form=6&db=m Rapamycin suppresses the PI3K/AKT/mTOR signaling pathway by targeting SIRT1 in esophageal cancer. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30145851&form=6&db=m Impact of curcumin on sirtuins: A review. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34116043&form=6&db=m SIRT1/PGC-1? signaling activation by mangiferin attenuates cerebral hypoxia/reoxygenation injury in neuroblastoma cells. therapeutic application,unassigned 1,0 2.3.1.286 Neural Tube Defects http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26896748&form=6&db=m High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23337935&form=6&db=m Resveratrol facilitates pain attenuation in a rat model of neuropathic pain through the activation of spinal sirt1. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26221253&form=6&db=m Intrathecal SRT1720, a SIRT1 agonist, exerts anti-hyperalgesic and anti-inflammatory effects on chronic constriction injury-induced neuropathic pain in rats. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29623757&form=6&db=m Icariin, a flavonoid with anti-cancer effects, alleviated paclitaxel-induced neuropathic pain in a SIRT1-dependent manner. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30649099&form=6&db=m SIRT1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32005763&form=6&db=m SIRT1 Decreases Emotional Pain Vulnerability with Associated CaMKII? Deacetylation in Central Amygdala. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33127810&form=6&db=m SIRT3 alleviates neuropathic pain by deacetylating FoxO3a in the spinal dorsal horn of diabetic model rats. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33182469&form=6&db=m Natural Antioxidant Control of Neuropathic Pain-Exploring the Role of Mitochondrial SIRT3 Pathway. causal interaction,unassigned 1,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34245841&form=6&db=m Downregulated SIRT1 in the CeA is involved in chronic pain-depression comorbidity. ongoing research,unassigned 1,0 2.3.1.286 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20972827&form=6&db=m Resveratrol Inhibits Proliferation and Promotes Apoptosis of Neuroblastoma Cells: Role of Sirtuin 1. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26891914&form=6&db=m Resveratrol augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29883958&form=6&db=m A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1. causal interaction,unassigned 1,0 2.3.1.286 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31846093&form=6&db=m Effect of atorvastatin on A?1-42 -induced alteration of SESN2, SIRT1, LC3II and TPP1 protein expressions in neuronal cell cultures. ongoing research,unassigned 1,0 2.3.1.286 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33316537&form=6&db=m SUMOylation is essential for Sirt2 tumor-suppressor function in neuroblastoma. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581637&form=6&db=m SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18373985&form=6&db=m Therapeutic role of sirtuins in neurodegenerative disease. causal interaction,unassigned 1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19441904&form=6&db=m Sirtuin inhibitors. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20004495&form=6&db=m SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22131404&form=6&db=m SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA. therapeutic application,unassigned 1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23417962&form=6&db=m SIRT1 and SIRT2: emerging targets in neurodegeneration. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23511834&form=6&db=m The Role SIRT2 in Programmed Necrosis: Implications for Stroke and Neurodegenerative Disorders. therapeutic application,unassigned 1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24946089&form=6&db=m Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways. therapeutic application,unassigned 1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25323555&form=6&db=m Age-dependent tissue expression patterns of Sirt1 in senescence-accelerated mice. therapeutic application,unassigned 1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25574479&form=6&db=m Sirtuin 1 activator SRT2104 protects Huntington's disease mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25815111&form=6&db=m SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28257421&form=6&db=m The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30532738&form=6&db=m Brain SIRT1 Mediates Metabolic Homeostasis and Neuroprotection. ongoing research,unassigned 1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31110473&form=6&db=m Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Diseases. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31357491&form=6&db=m Discovery of (5-Phenylfuran-2-yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33290206&form=6&db=m Sirtuin3 in Neurological Disorders. causal interaction,unassigned 1,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26448816&form=6&db=m Physical Training Regulates Mitochondrial Parameters and Neuroinflammatory Mechanisms in an Experimental Model of Parkinson's Disease. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28888980&form=6&db=m Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28939414&form=6&db=m Role of the epigenetic factor Sirt7 in neuroinflammation and neurogenesis. causal interaction,unassigned 1,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29311941&form=6&db=m Sirt3 Mediates the Inhibitory Effect of Adjudin on Astrocyte Activation and Glial Scar Formation following Ischemic Stroke. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30208700&form=6&db=m Eriodictyol Attenuates LPS-Induced Neuroinflammation, Amyloidogenesis, and Cognitive Impairments via the Inhibition of NF-?B in Male C57BL/6J Mice and BV2 Microglial Cells. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30456649&form=6&db=m Berberine ameliorates lipopolysaccharide-induced learning and memory deficit in the rat: insights into underlying molecular mechanisms. therapeutic application,unassigned 1,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31011489&form=6&db=m Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31991916&form=6&db=m Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 Levels Improving Cognition in Aged Rats. causal interaction,unassigned 1,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32212827&form=6&db=m Neuroprotective Effects of Trilobatin, a Novel Naturally Occurring Sirt3 Agonist from Lithocarpus polystachyus Rehd., Mitigate Cerebral Ischemia/Reperfusion Injury: Involvement of TLR4/NF-?B and Nrf2/Keap-1 Signaling. therapeutic application,unassigned 1,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32249647&form=6&db=m Laquinimod inhibits MMP+?induced NLRP3 inflammasome activation in human neuronal cells. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32343995&form=6&db=m Targeting sirtuin activity with nicotinamide riboside reduces neuroinflammation in a GWI mouse model. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33289070&form=6&db=m Activation of silent information regulator 1 exerts a neuroprotective effect after intracerebral hemorrhage by deacetylating NF-?B/p65. therapeutic application,unassigned 1,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33381265&form=6&db=m Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. causal interaction,unassigned 1,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33821324&form=6&db=m SIRT1 and SIRT2 modulators reduce LPS-induced inflammation in HAPI microglial cells and protect SH-SY5Y neuronal cells in vitro. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Nijmegen Breakage Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20097625&form=6&db=m Role of SIRT1 in homologous recombination. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22982377&form=6&db=m A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25045415&form=6&db=m Circulating levels of sirtuin 4, a potential marker of oxidative metabolism, related to coronary artery disease in obese patients suffering from NAFLD, with normal or slightly increased liver enzymes. diagnostic usage,ongoing research,unassigned 1,1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25544867&form=6&db=m Dietary blueberry and bifidobacteria attenuate nonalcoholic fatty liver disease in rats by affecting SIRT1-mediated signaling pathway. ongoing research,unassigned 1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27040510&form=6&db=m Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH. diagnostic usage,unassigned 1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28534819&form=6&db=m Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK. therapeutic application,unassigned 1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28592311&form=6&db=m The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28808418&form=6&db=m Emerging roles of SIRT1 in fatty liver diseases. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29266812&form=6&db=m Tomato Powder Inhibits Hepatic Steatosis and Inflammation Potentially Through Restoring SIRT1 Activity and Adiponectin Function Independent of Carotenoid Cleavage Enzymes in Mice. therapeutic application,unassigned 1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29696666&form=6&db=m Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease. therapeutic application,unassigned 1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30186546&form=6&db=m Corrigendum to "Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes". diagnostic usage,unassigned 1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30381838&form=6&db=m SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30580553&form=6&db=m n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review. ongoing research,unassigned 1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30848932&form=6&db=m Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30868489&form=6&db=m Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31160717&form=6&db=m SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31195981&form=6&db=m miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31500354&form=6&db=m Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32158242&form=6&db=m DHA Protects Against Hepatic Steatosis by Activating Sirt1 in a High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mouse Model. therapeutic application,unassigned 1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32351294&form=6&db=m Prevalence, clinical characteristics, risk factors, and indicators for lean Chinese adults with nonalcoholic fatty liver disease. diagnostic usage,unassigned 1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32520409&form=6&db=m Sirtuin 3-mediated deacetylation of acyl-CoA synthetase family member 3 by protocatechuic acid attenuates non-alcoholic fatty liver disease. therapeutic application,unassigned 1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32737656&form=6&db=m Electroacupuncture Attenuates Liver Inflammation in Nonalcoholic Fatty Liver Disease Rats. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32888948&form=6&db=m The effect of aerobic, resistance, and combined training on PPAR-?, SIRT1 gene expression, and insulin resistance in high-fat diet-induced NAFLD male rats. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33636024&form=6&db=m Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4?. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19652658&form=6&db=m Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20817729&form=6&db=m SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21345154&form=6&db=m Sirtuin 1 in lipid metabolism and obesity. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21514307&form=6&db=m Food restriction improves glucose and lipid metabolism through Sirt1 expression: a study using a new rat model with obesity and severe hypertension. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22883230&form=6&db=m High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24374551&form=6&db=m Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25044690&form=6&db=m Sirt1 rescues the obesity induced by insulin-resistant constitutively-nuclear FoxO1 in POMC neurons of male mice. ongoing research,unassigned 1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25050904&form=6&db=m Growth hormone signaling in muscle and adipose tissue of obese human subjects: associations with measures of body composition and interaction with resveratrol treatment. therapeutic application,unassigned 1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25159328&form=6&db=m High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25233986&form=6&db=m SIRT1 gene variants are related to risk of childhood obesity. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,1 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26368128&form=6&db=m ?-Mangostin Regulates Hepatic Steatosis and Obesity through SirT1-AMPK and PPAR? Pathways in High-Fat Diet-Induced Obese Mice. therapeutic application,unassigned 1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26463981&form=6&db=m The sirtuins: Markers of metabolic health. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26629408&form=6&db=m Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27058248&form=6&db=m Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29150224&form=6&db=m Reduced gene expression of sirtuins and active AMPK levels in children and adolescents with obesity and insulin resistance. therapeutic application,unassigned 1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30411173&form=6&db=m Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30532738&form=6&db=m Brain SIRT1 Mediates Metabolic Homeostasis and Neuroprotection. ongoing research,unassigned 1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30636176&form=6&db=m Lactobacillus sakei Alleviates High-Fat-Diet-Induced Obesity and Anxiety in Mice by Inducing AMPK Activation and SIRT1 Expression and Inhibiting Gut Microbiota-Mediated NF-?B Activation. ongoing research,unassigned 1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30868489&form=6&db=m Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31056880&form=6&db=m [Electroacupuncture reduces obesity by improving metabolism and up-regulating expression of hypothalamic Sirtuin 1 and proopiomelanocortin in obese rats]. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31318577&form=6&db=m The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31618980&form=6&db=m Gynostemma Pentaphyllum Extract Ameliorates High-Fat Diet-Induced Obesity in C57BL/6N Mice by Upregulating SIRT1. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31776436&form=6&db=m Correction to: ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation. therapeutic application,unassigned 1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31935731&form=6&db=m Acupuncture Targeting SIRT1 in the Hypothalamic Arcuate Nucleus Can Improve Obesity in High-Fat-Diet-Induced Rats with Insulin Resistance via an Anorectic Effect. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32007662&form=6&db=m Maize extract rich in ferulic acid and anthocyanins prevents high-fat-induced obesity in mice by modulating SIRT1, AMPK and IL-6 associated metabolic and inflammatory pathways. causal interaction,unassigned 1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32144905&form=6&db=m [Effect of electroacupuncture on silent information regulator 1, fork head transcription factor O1 and proopiomelanocortin in the hypothalamus of rats with obesity induced by high-fat diet]. therapeutic application,unassigned 1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32755834&form=6&db=m Decreased levels and activity of Sirt1 are modulated by increased miR-34a expression in adipose tissue mononuclear cells from subjects with overweight and obesity: A pilot study. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33202604&form=6&db=m Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,1 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34017061&form=6&db=m Proto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34103440&form=6&db=m SIRT1 CONTRIBUTES TO POLARIZATION OF PERIPHERAL BLOOD MONOCYTES BY INCREASING STAT6 EXPRESSION IN YOUNG PEOPLE WITH OVERWEIGHT AND LOW-RISK OBESITY. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34259411&form=6&db=m [Mechanism of electroacupuncture for regulation of lipid production and improvement in obesity by mediating Wnt/ ?-catenin pathway through activating SIRT1]. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Obesity, Maternal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21901160&form=6&db=m Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat offspring at weaning. ongoing research,unassigned 1,0 2.3.1.286 Obesity, Maternal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22982377&form=6&db=m A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Obesity, Maternal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31969089&form=6&db=m NAFLD at the interface of the mother-infant dyad. therapeutic application,unassigned 1,0 2.3.1.286 Ophthalmoplegia, Chronic Progressive External http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23046812&form=6&db=m Regulation of mitochondrial F(o)F(1)ATPase activity by Sirt3-catalyzed deacetylation and its deficiency in human cells harboring 4977bp deletion of mitochondrial DNA. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.3.1.286 Optic Atrophy, Autosomal Dominant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31173361&form=6&db=m Sirt3 modulate renal ischemia-reperfusion injury through enhancing mitochondrial fusion and activating the ERK-OPA1 signaling pathway. therapeutic application,unassigned 1,0 2.3.1.286 Optic Nerve Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33589779&form=6&db=m Rescue of retinal ganglion cells in optic nerve injury using cell-selective AAV mediated delivery of SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.3.1.286 Optic Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26329673&form=6&db=m Sirtuin 1 regulates lipid metabolism associated with optic nerve regeneration. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Optic Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33589779&form=6&db=m Rescue of retinal ganglion cells in optic nerve injury using cell-selective AAV mediated delivery of SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.3.1.286 Optic Neuritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28197299&form=6&db=m Sirtuins Expression and Their Role in Retinal Diseases. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24321436&form=6&db=m Sirt1 and osteoarthritis. Comments on the paper by Gabay et al.: "Sirt1-deficient mice exhibit an altered cartilage phenotype", Joint Bone Spine 2013. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28627522&form=6&db=m DOT1L safeguards cartilage homeostasis and protects against osteoarthritis. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29434702&form=6&db=m miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis. therapeutic application,unassigned 1,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30873124&form=6&db=m Sirt1 Promotes a Thermogenic Gene Program in Bone Marrow Adipocytes: From Mice to (Wo)Men. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30996115&form=6&db=m The role of sirtuin 1 and its activator, resveratrol in osteoarthritis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33556400&form=6&db=m SIRT3 ameliorates osteoarthritis via regulating chondrocyte autophagy and apoptosis through the PI3K/Akt/mTOR pathway. therapeutic application,unassigned 1,0 2.3.1.286 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33867853&form=6&db=m Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33987074&form=6&db=m miR-9-5p promotes wear-particle-induced osteoclastogenesis through activation of the SIRT1/NF-?B pathway. ongoing research,unassigned 1,0 2.3.1.286 Osteonecrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32967053&form=6&db=m SIRT1 Gene SNP rs932658 is Associated with Medication-Related Osteonecrosis of the Jaw. causal interaction,unassigned 1,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21713995&form=6&db=m Resveratrol promotes osteogenesis of human mesenchymal stem cells by up-regulating RUNX2 gene expression via SIRT1/FOXO3A axis. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25377437&form=6&db=m Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-?B signaling pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28339869&form=6&db=m Alcohol Induces Cellular Senescence and Impairs Osteogenic Potential in Bone Marrow-Derived Mesenchymal Stem Cells. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Osteoporosis, Postmenopausal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33577975&form=6&db=m Estrogen promotes lncRNA H19 expression to regulate osteogenic differentiation of BMSCs and reduce osteoporosis via miR-532-3p/SIRT1 axis. diagnostic usage,unassigned 1,0 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25998694&form=6&db=m MicroRNA-204 inhibits proliferation, migration, invasion and epithelial-mesenchymal transition in osteosarcoma cells via targeting Sirtuin 1. ongoing research,unassigned 1,0 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26628989&form=6&db=m Emodin inhibits HMGB1-induced tumor angiogenesis in human osteosarcoma by regulating SIRT1. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28810936&form=6&db=m LncRNA C2dat1 Promotes Cell Proliferation, Migration, and Invasion by Targeting MiR-34a-5p in Osteosarcoma Cells. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28979804&form=6&db=m Sirtuin 7 plays an oncogenic role in human osteosarcoma via downregulating CDC4 expression. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30881341&form=6&db=m Insulin/IGF-1R, SIRT1, and FOXOs Pathways-An Intriguing Interaction Platform for Bone and Osteosarcoma. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31070483&form=6&db=m MiR-217 Inhibits Proliferation, Migration, and Invasion by Targeting SIRT1 in Osteosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34080647&form=6&db=m [Retracted] MicroRNA-204 inhibits proliferation, migration, invasion and epithelial-mesenchymal transition in osteosarcoma cells via targeting Sirtuin 1. ongoing research,unassigned 1,0 2.3.1.286 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24922076&form=6&db=m Augmentation of NAD(+) by NQO1 attenuates cisplatin-mediated hearing impairment. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26341473&form=6&db=m Dunnione ameliorates cisplatin ototoxicity through modulation of NAD(+) metabolism. causal interaction,unassigned 1,0 2.3.1.286 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33900547&form=6&db=m Roles of Bak and Sirt3 in Paraquat-Induced Cochlear Hair Cell Damage. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21957481&form=6&db=m Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27114721&form=6&db=m Differential Effects of Estradiol and Bisphenol A on SET8 and SIRT1 Expression in Ovarian Cancer Cells. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27277143&form=6&db=m SIRT3 participates in glucose metabolism interruption and apoptosis induced by BH3 mimetic S1 in ovarian cancer cells. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28214851&form=6&db=m Lysophosphatidic Acid Promotes Epithelial to Mesenchymal Transition in Ovarian Cancer Cells by Repressing SIRT1. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29050034&form=6&db=m Mir-29b Regulates Oxidative Stress by Targeting SIRT1 in Ovarian Cancer Cells. therapeutic application,unassigned 1,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31038546&form=6&db=m Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ovarian cancer via miR-142. therapeutic application,unassigned 1,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32151067&form=6&db=m Ginsenoside Rp1, A Ginsenoside Derivative, Augments Anti-Cancer Effects of Actinomycin D via Downregulation of an AKT-SIRT1 Pathway. ongoing research,unassigned 1,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32349783&form=6&db=m Knockdown of long non-coding RNA HOTAIR reverses cisplatin resistance of ovarian cancer cells through inhibiting miR-138-5p-regulated EZH2 and SIRT1. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32495859&form=6&db=m PKMYT1 aggravates the progression of ovarian cancer by targeting SIRT3. therapeutic application,unassigned 1,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33207824&form=6&db=m ROS-Induced SIRT2 Upregulation Contributes to Cisplatin Sensitivity in Ovarian Cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34335684&form=6&db=m SIRT4 and SIRT6 Serve as Novel Prognostic Biomarkers With Competitive Functions in Serous Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34396428&form=6&db=m Ultrasound?targeted microbubble destruction?mediated overexpression of Sirtuin 3 inhibits the progression of ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 2.3.1.286 Overnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25948680&form=6&db=m Maternal High-Fat Feeding Increases Placental Lipoprotein Lipase Activity by Reducing SIRT1 Expression in Mice. therapeutic application,unassigned 1,0 2.3.1.286 Overnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29972782&form=6&db=m Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or ? Cell Metabolism in the Absence of Overnutrition. ongoing research,unassigned 1,0 2.3.1.286 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24612843&form=6&db=m [Rosuvastatin improves insulin sensitivity in overweight rats induced by high fat diet. Role of SIRT1 in adipose tissue.] causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28029409&form=6&db=m Serum concentrations and gene expression of sirtuin 1 in healthy and slightly overweight subjects after caloric restriction or resveratrol supplementation: A randomized trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.3.1.286 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30246793&form=6&db=m Inflammatory Cytokines and SIRT1 Levels in Subcutaneous Abdominal Fat: Relationship With Cardiac Performance in Overweight Pre-diabetics Patients. diagnostic usage,unassigned 1,0 2.3.1.286 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31011489&form=6&db=m Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32369778&form=6&db=m Resistance training increases muscle NAD+ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals. diagnostic usage,therapeutic application,unassigned 1,1,0 2.3.1.286 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32755834&form=6&db=m Decreased levels and activity of Sirt1 are modulated by increased miR-34a expression in adipose tissue mononuclear cells from subjects with overweight and obesity: A pilot study. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34103440&form=6&db=m SIRT1 CONTRIBUTES TO POLARIZATION OF PERIPHERAL BLOOD MONOCYTES BY INCREASING STAT6 EXPRESSION IN YOUNG PEOPLE WITH OVERWEIGHT AND LOW-RISK OBESITY. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23561972&form=6&db=m Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25275504&form=6&db=m Further characterization of HDAC and SIRT gene expression patterns in pancreatic cancer and their relation to disease outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25632225&form=6&db=m Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30487699&form=6&db=m Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer. therapeutic application,unassigned 1,0 2.3.1.286 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32462510&form=6&db=m Negative Regulation of SIRT1 by IRF9 Involved in Hyperlipidemia Acute Pancreatitis Associated with Kidney Injury. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17708669&form=6&db=m Linking SIRT2 to Parkinson's disease. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19441904&form=6&db=m Sirtuin inhibitors. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23200855&form=6&db=m The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23417962&form=6&db=m SIRT1 and SIRT2: emerging targets in neurodegeneration. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24792244&form=6&db=m Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: implications for Parkinson's disease. causal interaction,unassigned 1,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27163642&form=6&db=m SIRT2 regulates insulin sensitivity in insulin resistant neuronal cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28257421&form=6&db=m The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28379951&form=6&db=m Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. therapeutic application,unassigned 1,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29567426&form=6&db=m miR-494-3p modulates the progression of in vitro and in vivo Parkinson's disease models by targeting SIRT3. therapeutic application,unassigned 1,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29571747&form=6&db=m Cdk5 suppression blocks SIRT1 degradation via the ubiquitin-proteasome pathway in Parkinson's disease models. therapeutic application,unassigned 1,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30826419&form=6&db=m miR-9-5p modulates the progression of Parkinson's disease by targeting SIRT1. therapeutic application,unassigned 1,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32707370&form=6&db=m Theacrine, a purine alkaloid from kucha, protects against Parkinson's disease through SIRT3 activation. therapeutic application,unassigned 1,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32909152&form=6&db=m Reduced serum SIRT1 levels in patients with Parkinson's disease: a cross-sectional study in China. causal interaction,diagnostic usage,unassigned 1,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33253528&form=6&db=m Elucidating the Neuroprotective Role of Formulated Camel ?-Lactalbumin-Oleic Acid Complex by Curating the SIRT1 Pathway in Parkinson's Disease Model. ongoing research,unassigned 1,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33935952&form=6&db=m SIRT1 Deacetylates TET2 and Promotes Its Ubiquitination Degradation to Achieve Neuroprotection Against Parkinson's Disease. therapeutic application,unassigned 1,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34021216&form=6&db=m Gene variants and expression changes of SIRT1 and SIRT6 in peripheral blood are associated with Parkinson's disease. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32979381&form=6&db=m Potential therapeutic role of fibroblast growth factor 21 in neurodegeneration: Evidence for ameliorating parkinsonism via silent information regulator 2 homolog 1 and implication for gene therapy. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Pediatric Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25233986&form=6&db=m SIRT1 gene variants are related to risk of childhood obesity. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,1 2.3.1.286 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32122297&form=6&db=m Sirt2-associated transcriptome modifications in cisplatin-induced neuronal injury. therapeutic application,unassigned 1,0 2.3.1.286 Peritoneal Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33906673&form=6&db=m Ameliorative role of SIRT1 in peritoneal fibrosis: an in vivo and in vitro study. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 2.3.1.286 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30235590&form=6&db=m SIRT1 downregulation mediated Manganese-induced neuronal apoptosis through activation of FOXO3a-Bim/PUMA axis. diagnostic usage,ongoing research,unassigned 1,1,0 2.3.1.286 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31920915&form=6&db=m SIRT1 Protects Against Apoptosis by Promoting Autophagy in the Oxygen Glucose Deprivation/Reperfusion-Induced Injury. causal interaction,unassigned 1,0 2.3.1.286 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34294459&form=6&db=m MiR-155 regulates Th9 differentiation in children with methicillin-resistant Staphylococcus aureus pneumonia by targeting SIRT1. therapeutic application,unassigned 1,0 2.3.1.286 Pneumonia, Staphylococcal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34294459&form=6&db=m MiR-155 regulates Th9 differentiation in children with methicillin-resistant Staphylococcus aureus pneumonia by targeting SIRT1. therapeutic application,unassigned 1,0 2.3.1.286 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23778143&form=6&db=m Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Polycystic Kidney, Autosomal Dominant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23778143&form=6&db=m Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31906251&form=6&db=m Granulosa-Lutein Cell Sirtuin Gene Expression Profiles Differ between Normal Donors and Infertile Women. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32400763&form=6&db=m Role of some MiRNA Affecting Polycystic Ovarian Syndrome and SIRT1 levels. causal interaction,unassigned 1,0 2.3.1.286 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31366618&form=6&db=m LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Primary Ovarian Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34463232&form=6&db=m Ginsenoside Rg1 attenuates premature ovarian failure of D-gal induced POF mice through downregulating p16INK4a and upregulating SIRT1 expression. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Progeria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23217256&form=6&db=m Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. therapeutic application,unassigned 1,0 2.3.1.286 Progeria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34389865&form=6&db=m Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,1,4 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15692560&form=6&db=m Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. therapeutic application,unassigned 1,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22017869&form=6&db=m Peptide switch is essential for Sirt1 deacetylase activity. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22495798&form=6&db=m Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration-dependent modulation of multiple nuclear receptor-mediated pathways in androgen-responsive prostate cancer cell LNCaP. therapeutic application,unassigned 1,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26722316&form=6&db=m miR-34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28667915&form=6&db=m Knockdown of TNF receptor-associated factor 2 (TRAF2) modulates in vitro growth of TRAIL-treated prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29805651&form=6&db=m Nicotinamide N-methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.3.1.286 Prostatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28841456&form=6&db=m Resveratrol improves smooth muscle carcinogenesis in the progression of chronic prostatitis via the downregulation of c-kit/SCF by activating Sirt1. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18823944&form=6&db=m Inhibition of transcriptional activity of c-JUN by SIRT1. diagnostic usage,unassigned 1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20660252&form=6&db=m SIRT1 is essential for normal cognitive function and synaptic plasticity. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30124203&form=6&db=m [SIRT1 deficiency in CD4+T cells induces acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation]. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30216438&form=6&db=m LncRNA HOTAIR functions as a competing endogenous RNA to upregulate SIRT1 by sponging miR-34a in diabetic cardiomyopathy. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31145942&form=6&db=m Sirt1 counteracts decrease in membrane phospholipid unsaturation and diastolic dysfunction during saturated fatty acid overload. ongoing research,unassigned 1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31712596&form=6&db=m Sirtuin 3 deficiency does not impede digit regeneration in mice. therapeutic application,unassigned 1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32217463&form=6&db=m SIRT1 induces the adipogenic differentiation of mouse embryonic stem cells by regulating RA-induced RAR expression via NCOR1 acetylation. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33381265&form=6&db=m Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. causal interaction,unassigned 1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33418031&form=6&db=m Aconitine attenuates mitochondrial dysfunction of cardiomyocytes via promoting deacetylation of cyclophilin-D mediated by sirtuin-3. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24608443&form=6&db=m Role of Transcription Factor Acetylation in Diabetic Kidney Disease. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.3.1.286 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29782856&form=6&db=m Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30523229&form=6&db=m [Alpha-mangostin attenuates focal segmental glomerulosclerosis of mice induced by adriamycin]. therapeutic application,unassigned 1,0 2.3.1.286 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21098725&form=6&db=m STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 2.3.1.286 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34044769&form=6&db=m Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31749139&form=6&db=m Targeting histone acetylation in pulmonary hypertension and right ventricular hypertrophy. ongoing research,unassigned 1,0 2.3.1.286 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34239697&form=6&db=m Resveratrol Prevents Right Ventricle Dysfunction, Calcium Mishandling, and Energetic Failure via SIRT3 Stimulation in Pulmonary Arterial Hypertension. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22546858&form=6&db=m SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23897750&form=6&db=m Dysfunction of endothelial progenitor cells from smokers and COPD patients due to increased DNA damage and senescence. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24025728&form=6&db=m Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30641209&form=6&db=m Associations of the NRF2/KEAP1 pathway and antioxidant defense gene polymorphisms with chronic obstructive pulmonary disease. diagnostic usage,ongoing research,unassigned 1,1,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32106619&form=6&db=m Ticagrelor Increases SIRT1 and HES1 mRNA Levels in Peripheral Blood Cells from Patients with Stable Coronary Artery Disease and Chronic Obstructive Pulmonary Disease. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32897804&form=6&db=m Fengbaisan suppresses endoplasmic reticulum stress by up-regulating SIRT1 expression to protect rats with chronic obstructive pulmonary diseases. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33311978&form=6&db=m LINC00987 Ameliorates COPD by Regulating LPS-Induced Cell Apoptosis, Oxidative Stress, Inflammation and Autophagy Through Let-7b-5p/SIRT1 Axis. therapeutic application,unassigned 1,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33461161&form=6&db=m Inhibition of miR-494-3p alleviates oxidative stress-induced cell senescence and inflammation in the primary epithelial cells of COPD patients. causal interaction,unassigned 1,0 2.3.1.286 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31011489&form=6&db=m Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Radiation Fibrosis Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32222469&form=6&db=m Manganese porphyrin, MnTE-2-PyP, treatment protects the prostate from radiation-induced fibrosis (RIF) by activating the NRF2 signaling pathway and enhancing SOD2 and sirtuin activity. therapeutic application,unassigned 1,0 2.3.1.286 Radiculopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29748539&form=6&db=m SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21276800&form=6&db=m Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25277684&form=6&db=m The function of nicotinamide phosphoribosyltransferase in the heart. therapeutic application,unassigned 1,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25960048&form=6&db=m Caffeic acid attenuates rat liver reperfusion injury through sirtuin 3-dependent regulation of mitochondrial respiratory chain. causal interaction,unassigned 1,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26539534&form=6&db=m PPAR? Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury. ongoing research,unassigned 1,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28455824&form=6&db=m Diallyl trisulfide ameliorates myocardial ischemia-reperfusion injury by reducing oxidative stress and endoplasmic reticulum stress-mediated apoptosis in type 1 diabetic rats: role of SIRT1 activation. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28599575&form=6&db=m Suppression of miR-34a Expression in the Myocardium Protects Against Ischemia-Reperfusion Injury Through SIRT1 Protective Pathway. therapeutic application,unassigned 1,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29187652&form=6&db=m [Cordyceps sinensis protects HK2 cells from ischemia-reperfusion injury through Sirt1 pathway]. ongoing research,unassigned 1,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29862442&form=6&db=m Sirt3 inhibits cerebral ischemia-reperfusion injury through normalizing Wnt/?-catenin pathway and blocking mitochondrial fission. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29962953&form=6&db=m Sirt1 Activation by Post-ischemic Treatment With Lumbrokinase Protects Against Myocardial Ischemia-Reperfusion Injury. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31173361&form=6&db=m Sirt3 modulate renal ischemia-reperfusion injury through enhancing mitochondrial fusion and activating the ERK-OPA1 signaling pathway. therapeutic application,unassigned 1,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31726818&form=6&db=m Anesthetic preconditioning increases sirtuin 2 gene expression in a renal ischemia reperfusion injury model. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32239434&form=6&db=m Exendin-4 Protects Against Myocardial Ischemia-Reperfusion Injury by Upregulation of SIRT1 and SIRT3 and Activation of AMPK. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32373350&form=6&db=m Sirtuin 1: A Dilemma in Transplantation. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32453073&form=6&db=m MiR-7-5p Enhances Cerebral Ischemia-Reperfusion Injury by Degrading sirt1 mRNA. causal interaction,unassigned 1,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32895211&form=6&db=m [Effect of Shexiang Tongxin dripping pills on coronary microcirculation disorder and cardiac dysfunction in a porcine model of myocardial ischemia-reperfusion injury]. therapeutic application,unassigned 1,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33789208&form=6&db=m Sirtuin-3 mediates sex differences in kidney ischemia-reperfusion injury. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34454165&form=6&db=m Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by Sirt1. causal interaction,unassigned 1,0 2.3.1.286 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30205735&form=6&db=m CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18922599&form=6&db=m Sirt1 increases skeletal muscle precursor cell proliferation. causal interaction,unassigned 1,0 2.3.1.286 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31571997&form=6&db=m MicroRNA?506 regulates apoptosis in retinoblastoma cells by targeting sirtuin 1. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34355990&form=6&db=m microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials. ongoing research,unassigned 1,0 2.3.1.286 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28949386&form=6&db=m TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26055805&form=6&db=m Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing's sarcoma cells: resveratrol suppresses and SRT1720 enhances etoposide- and vincristine-induced anticancer activity. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25180292&form=6&db=m Sirt1 regulates canonical TGF-? signalling to control fibroblast activation and tissue fibrosis. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Scrapie http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25391763&form=6&db=m Scrapie Infection in Experimental Rodents and SMB-S15 Cells Decreased the Brain Endogenous Levels and Activities of Sirt1. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Seminoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28459202&form=6&db=m Estradiol via estrogen receptor beta influences ROS levels through the transcriptional regulation of SIRT3 in human seminoma TCam-2 cells. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25404738&form=6&db=m Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis. causal interaction,unassigned 1,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26522327&form=6&db=m Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28931916&form=6&db=m Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-?B and HMGB1 pathways through the upregulation of SIRT1. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30069485&form=6&db=m Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,1,3,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30500551&form=6&db=m Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30770245&form=6&db=m The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock. therapeutic application,unassigned 1,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33362546&form=6&db=m Melatonin Attenuates Sepsis-Induced Acute Lung Injury Through Improvement of Epithelial Sodium Channel-Mediated Alveolar Fluid Clearance Via Activation of SIRT1/SGK1/Nedd4-2 Signaling Pathway. causal interaction,unassigned 1,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33664465&form=6&db=m Tubeimoside I improves endothelial function in sepsis via activation of SIRT3. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33790896&form=6&db=m Melatonin Attenuates Sepsis-Induced Small-Intestine Injury by Upregulating SIRT3-Mediated Oxidative-Stress Inhibition, Mitochondrial Protection, and Autophagy Induction. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33869205&form=6&db=m Inhibiting miR-22 Alleviates Cardiac Dysfunction by Regulating Sirt1 in Septic Cardiomyopathy. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33891698&form=6&db=m Exosomal lncRNA-p21 derived from mesenchymal stem cells protects epithelial cells during LPS-induced acute lung injury by sponging miR-181. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33981237&form=6&db=m Dexmedetomidine Protects Against Septic Liver Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT1 Signaling Pathway. causal interaction,unassigned 1,0 2.3.1.286 Sepsis-Associated Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28236057&form=6&db=m Regulation of Sirtuin 3-Mediated Deacetylation of Cyclophilin D Attenuated Cognitive Dysfunction Induced by Sepsis-Associated Encephalopathy in Mice. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.286 Sertoli Cell-Only Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34355990&form=6&db=m microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials. ongoing research,unassigned 1,0 2.3.1.286 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26299770&form=6&db=m Selective Inhibition of SIRT2 Improves Outcomes in a Lethal Septic Model. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Sleep Apnea, Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30030618&form=6&db=m Effect of oral appliance on circulating leukocyte telomere length and SIRT1 in obstructive sleep apnea. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Sleep Deprivation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19627456&form=6&db=m Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Sleep Deprivation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25009250&form=6&db=m Sirtuin 3: a molecular pathway linking sleep deprivation to neurological diseases. therapeutic application,unassigned 1,0 2.3.1.286 Sleep Deprivation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31169197&form=6&db=m Melatonin modifies SOX2+ cell proliferation in dentate gyrus and modulates SIRT1 and MECP2 in long-term sleep deprivation. ongoing research,unassigned 1,0 2.3.1.286 Sleep Wake Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33038659&form=6&db=m Impact of circadian disruption on health; SIRT1 and Telomeres. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30355933&form=6&db=m Resveratrol Activated Sonic Hedgehog Signaling to Enhance Viability of NIH3T3 Cells in Vitro via Regulation of Sirt1. causal interaction,unassigned 1,0 2.3.1.286 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34051279&form=6&db=m Silencing of miR-324-5p alleviates rat spinal cord injury by Sirt1. ongoing research,unassigned 1,0 2.3.1.286 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25424420&form=6&db=m Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18485866&form=6&db=m A metabolic throttle regulates the epigenetic state of rDNA. therapeutic application,unassigned 1,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19029811&form=6&db=m Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues. causal interaction,unassigned 1,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20160399&form=6&db=m PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1. causal interaction,unassigned 1,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24875183&form=6&db=m SIRT1 mediates FOXA2 breakdown by deacetylation in a nutrient-dependent manner. therapeutic application,unassigned 1,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25601754&form=6&db=m Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation. therapeutic application,unassigned 1,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30131769&form=6&db=m Inverse Association of Circulating SIRT1 and Adiposity: A Study on Underweight, Normal Weight, and Obese Patients. therapeutic application,unassigned 1,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32446392&form=6&db=m SIRT1 enhances hepatitis virus B transcription independent of hepatic autophagy. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32499508&form=6&db=m SIRT1 accelerates the progression of activity-based anorexia. therapeutic application,unassigned 1,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22363646&form=6&db=m Activating Transcription Factor 4 Confers a Multidrug Resistance Phenotype to Gastric Cancer Cells through Transactivation of SIRT1 Expression. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24107295&form=6&db=m SIRT1 is downregulated in gastric cancer and leads to G1-phase arrest via NF-?B/Cyclin D1 signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,2 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27072976&form=6&db=m Prognostic and clinical value of Sirt1 expression in gastric cancer: A systematic meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30250020&form=6&db=m SIRT1 suppresses the migration and invasion of gastric cancer by regulating ARHGAP5 expression. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32051395&form=6&db=m SIRT1 inhibits chemoresistance and cancer stemness of gastric cancer by initiating an AMPK/FOXO3 positive feedback loop. diagnostic usage,therapeutic application,unassigned 1,1,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32508267&form=6&db=m MiRNA-12129 Suppresses Cell Proliferation and Block Cell Cycle Progression by Targeting SIRT1 in GASTRIC Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33894312&form=6&db=m Hsa-miR-34a-5p reverses multidrug resistance in gastric cancer cells by targeting the 3'-UTR of SIRT1 and inhibiting its expression. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31497199&form=6&db=m Inhibition of SIRT1 promotes taste bud stem cell survival and mitigates radiation-induced oral mucositis in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19288225&form=6&db=m Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23511834&form=6&db=m The Role SIRT2 in Programmed Necrosis: Implications for Stroke and Neurodegenerative Disorders. therapeutic application,unassigned 1,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23723308&form=6&db=m Silent information regulator 1 protects the brain against cerebral ischemic damage. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26167274&form=6&db=m Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced parkinsonism. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30145851&form=6&db=m Impact of curcumin on sirtuins: A review. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30422362&form=6&db=m Inhibition of calcium/calmodulin-dependent protein kinase kinase (CaMKK) exacerbates impairment of endothelial cell and blood-brain barrier after stroke. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32212827&form=6&db=m Neuroprotective Effects of Trilobatin, a Novel Naturally Occurring Sirt3 Agonist from Lithocarpus polystachyus Rehd., Mitigate Cerebral Ischemia/Reperfusion Injury: Involvement of TLR4/NF-?B and Nrf2/Keap-1 Signaling. therapeutic application,unassigned 1,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32381096&form=6&db=m Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats. therapeutic application,unassigned 1,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32676579&form=6&db=m Muscle-specific sirtuin1 gain-of-function ameliorates skeletal muscle atrophy in a pre-clinical mouse model of cerebral ischemic stroke. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34119577&form=6&db=m Ischemia Injury induces mPTP opening by reducing Sirt3. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.286 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32754040&form=6&db=m Berberine Ameliorates Subarachnoid Hemorrhage Injury via Induction of Sirtuin 1 and Inhibiting HMGB1/Nf-?B Pathway. causal interaction,unassigned 1,0 2.3.1.286 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33010255&form=6&db=m SIRT1 mediates hypoxic preconditioning induced attenuation of neurovascular dysfunction following subarachnoid hemorrhage. causal interaction,diagnostic usage,unassigned 1,4,0 2.3.1.286 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33924243&form=6&db=m Role of SIRT1 in Isoflurane Conditioning-Induced Neurovascular Protection against Delayed Cerebral Ischemia Secondary to Subarachnoid Hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.3.1.286 Synucleinopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28257421&form=6&db=m The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581637&form=6&db=m SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.3.1.286 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26715164&form=6&db=m Brain-derived neurotrophic factor Val66Met polymorphism in depression and thrombosis: SIRT1 as a possible mediator. diagnostic usage,unassigned 1,0 2.3.1.286 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30616245&form=6&db=m Deep Vein Thrombosis is Modulated by Inflammation Regulated via Sirtuin 1/NF-?B Signalling Pathway in a Rat Model. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 2.3.1.286 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32707369&form=6&db=m Spatholobi Caulis dispensing granule reduces deep vein thrombus burden through antiinflammation via SIRT1 and Nrf2. therapeutic application,unassigned 1,0 2.3.1.286 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34435654&form=6&db=m [Retracted] Function of miR?212 as a tumor suppressor in thyroid cancer by targeting SIRT1. therapeutic application,unassigned 1,0 2.3.1.286 Tics http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28604662&form=6&db=m Upregulation of mitochondrial NAD(+) levels impairs the clonogenicity of SSEA1(+) glioblastoma tumor-initiating cells. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.286 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25340339&form=6&db=m Dynamic partnership between TFIIH, PGC-1? and SIRT1 is impaired in trichothiodystrophy. causal interaction,diagnostic usage,unassigned 1,3,0 2.3.1.286 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26459286&form=6&db=m Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent ?-H2AX and telomerase regulation in triple-negative breast cancer. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30555597&form=6&db=m Layer-by-layer assembled gold nanoshells for the intracellular delivery of miR-34a. therapeutic application,unassigned 1,0 2.3.1.286 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30982660&form=6&db=m Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19747094&form=6&db=m Cloning and characterization of NAD-dependent protein deacetylase (Rv1151c) from Mycobacterium tuberculosis. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21627103&form=6&db=m Reversible acetylation and inactivation of Mycobacterium tuberculosis acetyl-CoA synthetase is dependent on cAMP. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32697192&form=6&db=m Host sirtuin 2 as an immunotherapeutic target against tuberculosis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 2.3.1.286 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29344236&form=6&db=m Alterations in expression levels of genes in p53-related pathways determined using RNA-Seq analysis in patients with breast cancer following CIK therapy. diagnostic usage,unassigned 1,0 2.3.1.286 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26257513&form=6&db=m CTGF siRNA ameliorates tubular cell apoptosis and tubulointerstitial fibrosis in obstructed mouse kidneys in a Sirt1-independent manner. causal interaction,unassigned 1,0 2.3.1.286 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33758176&form=6&db=m SIRT1 attenuates renal fibrosis by repressing HIF-2?. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.286 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27367652&form=6&db=m Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1). causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31285950&form=6&db=m Capsaicin attenuates cell migration via SIRT1 targeting and inhibition to enhance cortactin and ?-catenin acetylation in bladder cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.3.1.286 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32052927&form=6&db=m LncRNA MST1P2/miR-133b axis affects the chemoresistance of bladder cancer to cisplatin-based therapy via Sirt1/p53 signaling. diagnostic usage,therapeutic application,unassigned 1,2,0 2.3.1.286 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34471236&form=6&db=m SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis. diagnostic usage,ongoing research,unassigned 1,1,0 2.3.1.286 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20157519&form=6&db=m Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells. ongoing research,unassigned 1,0 2.3.1.286 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25770475&form=6&db=m TNF? Regulates SIRT1 Cleavage during Ocular Autoimmune Disease. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.286 Vascular Calcification http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32229709&form=6&db=m Intermedin1-53 attenuates aging-associated vascular calcification in rats by upregulating sirtuin 1. therapeutic application,unassigned 1,0 2.3.1.286 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22146233&form=6&db=m Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle. causal interaction,unassigned 1,0 2.3.1.286 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27573670&form=6&db=m SIRT1 mediates the actions of PPAR? on the oxLDL-triggered migration and proliferation of vascular smooth muscle cells. causal interaction,unassigned 1,0 2.3.1.286 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32796661&form=6&db=m Impact of Short-Term Hypoxia on Sirtuins as Regulatory Elements in HUVECs. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33304318&form=6&db=m SIRT1 Antagonizes Oxidative Stress in Diabetic Vascular Complication. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 2.3.1.286 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33010255&form=6&db=m SIRT1 mediates hypoxic preconditioning induced attenuation of neurovascular dysfunction following subarachnoid hemorrhage. causal interaction,diagnostic usage,unassigned 1,4,0 2.3.1.286 Venous Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30616245&form=6&db=m Deep Vein Thrombosis is Modulated by Inflammation Regulated via Sirtuin 1/NF-?B Signalling Pathway in a Rat Model. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 2.3.1.286 Venous Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31528671&form=6&db=m Data for DHK effect on thrombus weight, blood coagulation, blood cell counts and whole blood viscosity in deep vein thrombosis rats. therapeutic application,unassigned 1,0 2.3.1.286 Venous Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33638947&form=6&db=m LncRNA Sirt1-AS upregulates Sirt1 to attenuate aging related deep venous thrombosis. therapeutic application,unassigned 1,0 2.3.1.286 Ventricular Dysfunction, Left http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23024374&form=6&db=m Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress. therapeutic application,unassigned 1,0 2.3.1.286 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20577263&form=6&db=m SIRT1 stabilizes PML promoting its sumoylation. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.286 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19474721&form=6&db=m SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty. therapeutic application,unassigned 1,0 2.3.1.286 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33920458&form=6&db=m Melatonin Inhibits Dengue Virus Infection via the Sirtuin 1-Mediated Interferon Pathway. therapeutic application,unassigned 1,0 2.3.1.286 Vitiligo http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33152110&form=6&db=m The long noncoding RNA MALAT1 suppresses miR-211 to confer protection from ultraviolet-mediated DNA damage in vitiligo epidermis by upregulating sirtuin 1. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25815111&form=6&db=m SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.3.1.286 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32512788&form=6&db=m Cold-Pressed Nigella Sativa Oil Standardized to 3% Thymoquinone Potentiates Omega-3 Protection against Obesity-Induced Oxidative Stress, Inflammation, and Markers of Insulin Resistance Accompanied with Conversion of White to Beige Fat in Mice. causal interaction,unassigned 1,0 2.3.1.286 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23267107&form=6&db=m Sirt1 suppresses RNA synthesis after UV irradiation in combined xeroderma pigmentosum group D/Cockayne syndrome (XP-D/CS) cells. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.286 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22443029&form=6&db=m New clinical findings on the longevity gene in disease, health, & longevity: Sirtuin 1 often decreases with advanced age & serious diseases in most parts of the human body, while relatively high & constant Sirtuin 1 regardless of age was first found in the hippocampus of supercentenarians. causal interaction,diagnostic usage,unassigned 2,2,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20139070&form=6&db=m Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21416250&form=6&db=m Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23302720&form=6&db=m The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31218880&form=6&db=m S-Sulfhydration of SIRT3 by Hydrogen Sulfide Attenuates Mitochondrial Dysfunction in Cisplatin-Induced Acute Kidney Injury. causal interaction,unassigned 2,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32673294&form=6&db=m Calcitonin Gene-Related Peptide Attenuates LPS-Induced Acute Kidney Injury by Regulating Sirt1. therapeutic application,unassigned 2,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33637691&form=6&db=m SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation. causal interaction,unassigned 2,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23625030&form=6&db=m Resveratrol reduces acute lung injury in a LPS?induced sepsis mouse model via activation of Sirt1. ongoing research,therapeutic application,unassigned 4,2,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29351405&form=6&db=m Acute down-regulation of miR-199a attenuates sepsis-induced acute lung injury by targeting SIRT1. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31949845&form=6&db=m Downregulation of miR-155 attenuates sepsis-induced acute lung injury by targeting SIRT1. causal interaction,unassigned 2,0 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30252536&form=6&db=m RAR? acts as both an upstream regulator and downstream effector of miR-22, which epigenetically regulates NUR77 to induce apoptosis of colon cancer cells. causal interaction,diagnostic usage,unassigned 2,2,0 2.3.1.286 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28164517&form=6&db=m Prognostic and Predictive Role of Sirtuin1 Expression in Lung Adenocarcinoma. diagnostic usage,unassigned 2,0 2.3.1.286 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29564694&form=6&db=m Differential gene expression of sirtuins between somatotropinomas and nonfunctioning pituitary adenomas. causal interaction,diagnostic usage,unassigned 2,1,0 2.3.1.286 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30460421&form=6&db=m The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,3 2.3.1.286 Adenoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25961022&form=6&db=m {2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3. ongoing research,unassigned 2,0 2.3.1.286 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24141423&form=6&db=m Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,2 2.3.1.286 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24166142&form=6&db=m Diabetic nephropathy: Sirt1 attenuates diabetic albuminuria. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32657157&form=6&db=m Role of SIRT1 in HIV-associated kidney disease. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16183991&form=6&db=m SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. causal interaction,therapeutic application,unassigned 2,3,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18376059&form=6&db=m Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19749416&form=6&db=m Sirtuins as Novel Targets for Alzheimer's Disease and Other Neurodegenerative Disorders: Experimental and Genetic Evidence. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20061622&form=6&db=m Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21861060&form=6&db=m [Neuroprotective role of silent information regulator 1 in Alzheimer's disease]. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22836009&form=6&db=m SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's Disease. diagnostic usage,ongoing research,unassigned 2,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24046746&form=6&db=m Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. causal interaction,therapeutic application,unassigned 2,3,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24497179&form=6&db=m The SIRT2 Polymorphism rs10410544 and Risk of Alzheimer's Disease: A Meta-analysis. causal interaction,diagnostic usage,unassigned 2,3,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24860504&form=6&db=m Sirtuin modulators control reactive gliosis in an in vitro model of Alzheimer's disease. ongoing research,unassigned 2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27372638&form=6&db=m Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-? Protein Precursor Processing in Two Alzheimer's Disease Mouse Models. therapeutic application,unassigned 2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28703423&form=6&db=m The emerging role of alternative splicing in senescence and aging. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29358553&form=6&db=m miR-200a-3p promotes b-Amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer's disease. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30144538&form=6&db=m The relationship between four GWAS-identified loci in Alzheimer's disease and the risk of Parkinson's disease, amyotrophic lateral sclerosis, and multiple system atrophy. causal interaction,unassigned 2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31812544&form=6&db=m Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32003755&form=6&db=m The neuroprotective effects of SIRT1 in mice carrying the APP/PS1 double-transgenic mutation and in SH-SY5Y cells over-expressing human APP670/671 may involve elevated levels of ?7 nicotinic acetylcholine receptors. ongoing research,unassigned 2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33448178&form=6&db=m [Sirt3 gene knockout protects mice from Alzheimer's disease through activating autophagy]. ongoing research,therapeutic application,unassigned 4,2,0 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22796962&form=6&db=m Differential Sirtuin Expression Patterns in Amyotrophic Lateral Sclerosis (ALS) Postmortem Tissue: Neuroprotective or Neurotoxic Properties of Sirtuins in ALS?. ongoing research,unassigned 2,0 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24046746&form=6&db=m Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. causal interaction,therapeutic application,unassigned 2,3,0 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31812544&form=6&db=m Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Aneurysm, Dissecting http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32324654&form=6&db=m Resveratrol Attenuates Aortic Dissection by Increasing Endothelial Barrier Function Through the SIRT1 Pathway. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Arteriosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19591274&form=6&db=m [Sir2 gene] causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25270204&form=6&db=m [The cytokine homeostasis was regulated by over-expression of Sirt1 in collagen-induced arthritis mice]. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,4,1 2.3.1.286 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34023442&form=6&db=m Quercetin-mediated SIRT1 activation attenuates collagen-induced mice arthritis. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.3.1.286 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25270204&form=6&db=m [The cytokine homeostasis was regulated by over-expression of Sirt1 in collagen-induced arthritis mice]. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,4,1 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20103932&form=6&db=m Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory? therapeutic application,unassigned 2,0 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26956118&form=6&db=m SIRT1 inhibits differentiation of monocytes to macrophages: amelioration of synovial inflammation in rheumatoid arthritis. causal interaction,ongoing research,unassigned 2,1,0 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29105466&form=6&db=m [Effect of Warm Needle Moxibustion Intervention on Knee-joint Swelling and Expression of Synovial SIRT 1 and NF-?B in Rats with Rheumatoid Arthritis]. ongoing research,unassigned 2,0 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29784872&form=6&db=m SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-?B pathway. therapeutic application,unassigned 2,0 2.3.1.286 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32050426&form=6&db=m Sirtuin 1: Endocan and Sestrin 2 in Different Biological Samples in Patients with Asthma. Does Severity Make the Difference? causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28236278&form=6&db=m Tat-Mediated Induction of miRs-34a & -138 Promotes Astrocytic Activation via Downregulation of SIRT1: Implications for Aging in HAND. ongoing research,unassigned 2,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21293192&form=6&db=m Protective roles of SIRT1 in atherosclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,4 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23296669&form=6&db=m Methods to investigate the role of SIRT1 in endothelial senescence. ongoing research,unassigned 2,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26141671&form=6&db=m Metformin ameliorates the proinflammatory state in patients with carotid artery atherosclerosis through sirtuin 1 induction. causal interaction,unassigned 2,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27063143&form=6&db=m Mitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: potential implications in atherosclerosis. causal interaction,ongoing research,unassigned 2,1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27080738&form=6&db=m SIRT1 improves VSMC functions in atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30805760&form=6&db=m Assessing the performance of three resveratrol in binding with SIRT1 by molecular dynamics simulation and MM/GBSA methods: the weakest binding of resveratrol 3 to SIRT1 triggers a possibility of dissociation from its binding site. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33610576&form=6&db=m Role of histone deacetylase Sirt3 in the development and regression of atherosclerosis. causal interaction,ongoing research,unassigned 2,2,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34038763&form=6&db=m Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosis. causal interaction,ongoing research,unassigned 2,2,0 2.3.1.286 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22980663&form=6&db=m [Expression of SIRT1 in right auricle tissues and the relationship with oxidative stress in patients with atrial fibrillation]. causal interaction,ongoing research,unassigned 2,1,0 2.3.1.286 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22312127&form=6&db=m Three novel acetylation sites in the foxp3 transcription factor regulate the suppressive activity of regulatory T cells. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32042025&form=6&db=m Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Bicuspid Aortic Valve Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22370592&form=6&db=m Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease. ongoing research,unassigned 2,0 2.3.1.286 Bone Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32705163&form=6&db=m Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration. ongoing research,unassigned 2,0 2.3.1.286 Bone Diseases, Metabolic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28914882&form=6&db=m SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress. causal interaction,ongoing research,unassigned 2,3,0 2.3.1.286 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29433736&form=6&db=m The Role of FoxOs in Bone Health and Disease. diagnostic usage,therapeutic application,unassigned 2,2,0 2.3.1.286 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29775898&form=6&db=m Particle-induced SIRT1 downregulation promotes osteoclastogenesis and osteolysis through ER stress regulation. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.3.1.286 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25820186&form=6&db=m Heme oxygenase-1 modulates microRNA expression in cultured astroglia: implications for chronic brain disorders. ongoing research,unassigned 2,0 2.3.1.286 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29480757&form=6&db=m PDGFR-? modulates vascular smooth muscle cell phenotype via IRF-9/SIRT-1/NF-?B pathway in subarachnoid hemorrhage rats. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33664650&form=6&db=m Neuroprotective Effects of Exercise Postconditioning After Stroke via SIRT1-Mediated Suppression of Endoplasmic Reticulum (ER) Stress. causal interaction,unassigned 2,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34371139&form=6&db=m c-myc protects mice from ischemia stroke through elevating microRNA-200b-5p-regulated SIRT1 expression. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26523980&form=6&db=m Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19272442&form=6&db=m Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation. therapeutic application,unassigned 2,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29018134&form=6&db=m Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31076789&form=6&db=m SIRT1 Activation: A Potential Strategy for Harnessing Endogenous Protection Against Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18235502&form=6&db=m Negative regulation of the deacetylase SIRT1 by DBC1. ongoing research,therapeutic application,unassigned 4,2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19127863&form=6&db=m [Mechanism of apoptosis induced by SIRT1 deacetylase inhibitors in human breast cancer MCF-7 drug-resistant cells] ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21947282&form=6&db=m SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. causal interaction,ongoing research,unassigned 2,3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22464458&form=6&db=m Novel acridinedione derivatives: design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23583181&form=6&db=m SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis. causal interaction,ongoing research,unassigned 2,3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24183459&form=6&db=m SIRT2: tumour suppressor or tumour promoter in operable breast cancer? causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25826085&form=6&db=m Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25855962&form=6&db=m Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1? destabilization. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27600429&form=6&db=m Isoalantolactone induces apoptosis in human breast cancer cells via ROS-mediated mitochondrial pathway and downregulation of SIRT1. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30460421&form=6&db=m The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,3 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30876970&form=6&db=m Cyanidin-3-glucoside induces mesenchymal to epithelial transition via activating Sirt1 expression in triple negative breast cancer cells. ongoing research,unassigned 2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32165310&form=6&db=m Impact of structurally diverse BET inhibitors on SIRT1. ongoing research,unassigned 2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32244715&form=6&db=m Sirt3 Exerts Its Tumor-Suppressive Role by Increasing p53 and Attenuating Response to Estrogen in MCF-7 Cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34458803&form=6&db=m Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of ?-tubulin acetylation and inhibition of breast cancer cell migration. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Bronchopulmonary Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29115559&form=6&db=m Attenuated SUMOylation of sirtuin 1 in premature neonates with bronchopulmonary dysplasia. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19503100&form=6&db=m SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol. ongoing research,therapeutic application,unassigned 4,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20670893&form=6&db=m SIRT1 regulates UV-induced DNA repair through deacetylating XPA. causal interaction,unassigned 2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21358671&form=6&db=m SirT3 suppresses hypoxia inducible factor 1? and tumor growth by inhibiting mitochondrial ROS production. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21636977&form=6&db=m Human SIRT1 associates with mitotic chromatin and contributes to chromosomal condensation. causal interaction,unassigned 2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21775285&form=6&db=m The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy. ongoing research,unassigned 2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23604120&form=6&db=m Sorting out functions of sirtuins in cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24441046&form=6&db=m Dual role of SIRT1 in UVB-induced skin tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25761483&form=6&db=m Forkhead Transcription Factor FOXO1 Inhibits Angiogenesis in Gastric Cancer in Relation to SIRT1. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26787900&form=6&db=m SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions. causal interaction,diagnostic usage,unassigned 2,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26898440&form=6&db=m MicroRNA-132 cause apoptosis of glioma cells through blockade of the SREBP-1c metabolic pathway related to SIRT1. causal interaction,ongoing research,unassigned 2,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27997115&form=6&db=m SIRT7 Is an RNA-Activated Protein Lysine Deacylase. causal interaction,unassigned 2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29427626&form=6&db=m Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30182136&form=6&db=m Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin. causal interaction,ongoing research,unassigned 2,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30835165&form=6&db=m Sirt2 Regulates Radiation-Induced Injury. causal interaction,ongoing research,unassigned 2,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24240701&form=6&db=m SIRT1 and AMPK mediate hypoxia-induced resistance of non-small cell lung cancers to cisplatin and doxorubicin. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24441046&form=6&db=m Dual role of SIRT1 in UVB-induced skin tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25312940&form=6&db=m AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27022940&form=6&db=m SIRT1 prevents hyperuricemia via the PGC-1?/PPAR?-ABCG2 pathway. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27720890&form=6&db=m SIRT1 overexpression in cervical squamous intraepithelial lesions and invasive squamous cell carcinoma. causal interaction,unassigned 2,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30182136&form=6&db=m Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin. causal interaction,ongoing research,unassigned 2,3,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33627431&form=6&db=m The deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early tumorigenesis. causal interaction,diagnostic usage,unassigned 2,3,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34310804&form=6&db=m Silent information regulator 2 promotes clear cell renal cell carcinoma progression through deacetylation and small ubiquitin-related modifier 1 modification of glucose 6-phosphate dehydrogenase. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,1 2.3.1.286 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30182136&form=6&db=m Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin. causal interaction,ongoing research,unassigned 2,3,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22448750&form=6&db=m SirT1 regulates radiosensitivity of hepatoma cells differently under normoxic and hypoxic conditions. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23162614&form=6&db=m DBC1 does not function as a negative regulator of SIRT1 in liver cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25961022&form=6&db=m {2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3. ongoing research,unassigned 2,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25975503&form=6&db=m HSP90 and SIRT3 expression in hepatocellular carcinoma and their effect on invasive capability of human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33794741&form=6&db=m The ménage à trois of autophagy, lipid droplets and liver disease. ongoing research,unassigned 2,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33955831&form=6&db=m Long noncoding RNA PP7080 promotes hepatocellular carcinoma development by sponging mir-601 and targeting SIRT1. causal interaction,unassigned 2,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24240701&form=6&db=m SIRT1 and AMPK mediate hypoxia-induced resistance of non-small cell lung cancers to cisplatin and doxorubicin. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27501149&form=6&db=m Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer. causal interaction,unassigned 2,0 2.3.1.286 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34310804&form=6&db=m Silent information regulator 2 promotes clear cell renal cell carcinoma progression through deacetylation and small ubiquitin-related modifier 1 modification of glucose 6-phosphate dehydrogenase. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,1 2.3.1.286 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24441046&form=6&db=m Dual role of SIRT1 in UVB-induced skin tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27720890&form=6&db=m SIRT1 overexpression in cervical squamous intraepithelial lesions and invasive squamous cell carcinoma. causal interaction,unassigned 2,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21775285&form=6&db=m The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy. ongoing research,unassigned 2,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25281201&form=6&db=m Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1. therapeutic application,unassigned 2,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25614777&form=6&db=m SIRT1 functions as an important regulator of estrogen-mediated cardiomyocyte protection in angiotensin II-induced heart hypertrophy. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27423420&form=6&db=m NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy. causal interaction,unassigned 2,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27819129&form=6&db=m Roles of SIRT3 in heart failure: from bench to bedside. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29440391&form=6&db=m SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis. causal interaction,ongoing research,unassigned 2,4,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34379994&form=6&db=m SIRT1: a promising therapeutic target in type 2 diabetes mellitus. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25639460&form=6&db=m Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26202177&form=6&db=m Resveratrol prevents doxorubicin-induced cardiotoxicity in H9c2 cells through the inhibition of endoplasmic reticulum stress and the activation of the Sirt1 pathway. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31677784&form=6&db=m MicroRNA-22 inhibition prevents doxorubicin-induced cardiotoxicity via upregulating SIRT1. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33129330&form=6&db=m Exosomal LncRNA-NEAT1 derived from MIF-treated mesenchymal stem cells protected against doxorubicin-induced cardiac senescence through sponging miR-221-3p. therapeutic application,unassigned 2,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33438055&form=6&db=m Molecular mechanisms of doxorubicin-induced cardiotoxicity: novel roles of sirtuin 1-mediated signaling pathways. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33542782&form=6&db=m Protective Effects of Oroxylin A against Doxorubicin-Induced Cardiotoxicity via the Activation of Sirt1 in Mice. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20819950&form=6&db=m Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria? ongoing research,unassigned 2,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28661724&form=6&db=m SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection. causal interaction,unassigned 2,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30165439&form=6&db=m Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase in smooth muscle cells. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30574122&form=6&db=m Sirtuins and Insulin Resistance. causal interaction,unassigned 2,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30805760&form=6&db=m Assessing the performance of three resveratrol in binding with SIRT1 by molecular dynamics simulation and MM/GBSA methods: the weakest binding of resveratrol 3 to SIRT1 triggers a possibility of dissociation from its binding site. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32214805&form=6&db=m The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and ?Klotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis. causal interaction,unassigned 2,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32982786&form=6&db=m The Role of Sirtuin-1 in the Vasculature: Focus on Aortic Aneurysm. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,2,0 2.3.1.286 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26716364&form=6&db=m SIRT1 Protects Human Lens Epithelial Cells Against Oxidative Stress by Inhibiting p53-Dependent Apoptosis. therapeutic application,unassigned 2,0 2.3.1.286 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26929595&form=6&db=m Silent information regulator T1 in aqueous humor of patients with cataract. diagnostic usage,ongoing research,unassigned 2,2,0 2.3.1.286 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31582653&form=6&db=m Potential Therapeutic Agents, Polymethoxylated Flavones Isolated from Kaempferia parviflora for Cataract Prevention through Inhibition of Matrix Metalloproteinase-9 in Lens Epithelial Cells. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32540353&form=6&db=m Honokiol attenuates oxidative stress-dependent heart dysfunction in chronic Chagas disease by targeting AMPK / NFE2L2 / SIRT3 signaling pathway. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30989893&form=6&db=m [Effect of geniposidic acid on hepato-enteric circulation in cholestasis rats through Sirt1-FXR signaling pathway]. ongoing research,unassigned 2,0 2.3.1.286 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25608526&form=6&db=m Methyl-deficient diet promotes colitis and SIRT1-mediated endoplasmic reticulum stress. causal interaction,unassigned 2,0 2.3.1.286 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28655643&form=6&db=m Activation of sirtuin 1 by catalpol-induced down-regulation of microRNA-132 attenuates endoplasmic reticulum stress in colitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30605226&form=6&db=m Sirtuin-1 in immunotherapy: A Janus-headed target. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34380504&form=6&db=m Anti-inflammatory and -apoptotic effects of a long-term herbal extract treatment on DSS-induced colitis in mice fed with high AGEs-fat diet. ongoing research,unassigned 2,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25312940&form=6&db=m AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,4,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30252536&form=6&db=m RAR? acts as both an upstream regulator and downstream effector of miR-22, which epigenetically regulates NUR77 to induce apoptosis of colon cancer cells. causal interaction,diagnostic usage,unassigned 2,2,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31058315&form=6&db=m Long noncoding RNA FOXD3-AS1 promotes colon adenocarcinoma progression and functions as a competing endogenous RNA to regulate SIRT1 by sponging miR-135a-5p. causal interaction,diagnostic usage,unassigned 2,4,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33766523&form=6&db=m IL-1? induces expression of proinflammatory cytokines and migration of human colon cancer cells through upregulation of SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33931868&form=6&db=m Downregulation of SUN2 promotes metastasis of colon cancer by activating BDNF/TrkB signalling by interacting with SIRT1. causal interaction,unassigned 2,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20041875&form=6&db=m Frameshift mutation of SIRT1 gene in gastric and colorectal carcinomas with microsatellite instability. ongoing research,unassigned 2,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30016968&form=6&db=m Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30066578&form=6&db=m Anticancer activities of a benzimidazole compound through sirtuin inhibition in colorectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30312725&form=6&db=m Long non-coding RNA NEAT1 promotes colorectal cancer progression by competitively binding miR-34a with SIRT1 and enhancing the Wnt/?-catenin signaling pathway. causal interaction,unassigned 2,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30460421&form=6&db=m The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,3 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31632470&form=6&db=m BZD9L1 sirtuin inhibitor as a potential adjuvant for sensitization of colorectal cancer cells to 5-fluorouracil. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34171380&form=6&db=m BZD9L1 sirtuin inhibitor: Identification of key molecular targets and their biological functions in HCT 116 colorectal cancer cells. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Congenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32212452&form=6&db=m [Advances in the studies of teratospermia-related genes]. therapeutic application,unassigned 2,0 2.3.1.286 Corneal Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30794763&form=6&db=m Sirt3 regulates mitophagy level to promote diabetic corneal epithelial wound healing. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0 2.3.1.286 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33849089&form=6&db=m MiR-339 is a potential biomarker of coronary heart disease to aggravate oxidative stress through Nrf2/FOXO3 targeting Sirt2. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Cytomegalovirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33857259&form=6&db=m The antiviral sirtuin 3 bridges protein acetylation to mitochondrial integrity and metabolism during human cytomegalovirus infection. ongoing research,unassigned 2,0 2.3.1.286 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19591274&form=6&db=m [Sir2 gene] causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27663717&form=6&db=m Phytosterols and Dementia. causal interaction,unassigned 2,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20103932&form=6&db=m Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory? therapeutic application,unassigned 2,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26637398&form=6&db=m Association of Genetic Variants of SIRT1 With Type 2 Diabetes Mellitus. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27789474&form=6&db=m P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1. therapeutic application,unassigned 2,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28912956&form=6&db=m Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus. ongoing research,therapeutic application,unassigned 4,2,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29675132&form=6&db=m Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway. causal interaction,unassigned 2,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29779969&form=6&db=m Increased malondialdehyde vs. reduced sirtuin 1 in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30257324&form=6&db=m Biochanin A improves insulin sensitivity and controls hyperglycemia in type 2 diabetes. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30574122&form=6&db=m Sirtuins and Insulin Resistance. causal interaction,unassigned 2,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31557786&form=6&db=m Proposed Tandem Effect of Physical Activity and Sirtuin 1 and 3 Activation in Regulating Glucose Homeostasis. therapeutic application,unassigned 2,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31920356&form=6&db=m Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake. ongoing research,unassigned 2,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34379994&form=6&db=m SIRT1: a promising therapeutic target in type 2 diabetes mellitus. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19167483&form=6&db=m SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20105289&form=6&db=m Sirtuin1-p53, forkhead box O3a, p38 and post-infarct cardiac remodeling in the spontaneously diabetic Goto-Kakizaki rat. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23070058&form=6&db=m Poor glycaemic control in type 2 diabetes patients reduces endothelial progenitor cell number by influencing SIRT1 signalling via platelet-activating factor receptor activation. ongoing research,unassigned 2,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24446723&form=6&db=m A Phase II, Randomized, Placebo-Controlled, Double-Blind, Multi-Dose Study of SRT2104, a SIRT1 Activator, in Subjects With Type 2 Diabetes. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24717514&form=6&db=m Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26015978&form=6&db=m AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26637398&form=6&db=m Association of Genetic Variants of SIRT1 With Type 2 Diabetes Mellitus. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27563694&form=6&db=m Understanding Genetic Heterogeneity in Type 2 Diabetes by Delineating Physiological Phenotypes: SIRT1 and its Gene Network in Impaired Insulin Secretion. ongoing research,unassigned 2,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28912956&form=6&db=m Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus. ongoing research,therapeutic application,unassigned 4,2,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29779969&form=6&db=m Increased malondialdehyde vs. reduced sirtuin 1 in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30257324&form=6&db=m Biochanin A improves insulin sensitivity and controls hyperglycemia in type 2 diabetes. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30574122&form=6&db=m Sirtuins and Insulin Resistance. causal interaction,unassigned 2,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31557786&form=6&db=m Proposed Tandem Effect of Physical Activity and Sirtuin 1 and 3 Activation in Regulating Glucose Homeostasis. therapeutic application,unassigned 2,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31920356&form=6&db=m Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake. ongoing research,unassigned 2,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32033527&form=6&db=m Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32187456&form=6&db=m Trifolium pratense (Red Clover) Improve SIRT1 Expression and Glycogen Content in High Fat Diet-Streptozotocin Induced Type 2 Diabetes in Rats. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34379994&form=6&db=m SIRT1: a promising therapeutic target in type 2 diabetes mellitus. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25311234&form=6&db=m Sirt3 is essential for apelin-induced angiogenesis in post-myocardial infarction of diabetes. causal interaction,unassigned 2,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30857947&form=6&db=m Blockage of ROS and MAPKs-mediated inflammation via restoring SIRT1 by a new compound LF10 prevents type 1 diabetic cardiomyopathy. causal interaction,unassigned 2,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33637069&form=6&db=m Taohuajing reduces oxidative stress and inflammation in diabetic cardiomyopathy through the sirtuin 1/nucleotide-binding oligomerization domain-like receptor protein 3 pathway. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24166142&form=6&db=m Diabetic nephropathy: Sirt1 attenuates diabetic albuminuria. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25035926&form=6&db=m Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy. therapeutic application,unassigned 2,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30778838&form=6&db=m Hydrogen sulfide modulates SIRT1 and suppresses oxidative stress in diabetic nephropathy. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31154726&form=6&db=m [The renal protective effect and mechanism of liraglutide in diabetic mice induced by high-fat diet]. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24894401&form=6&db=m Sirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy. causal interaction,ongoing research,unassigned 2,2,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26238659&form=6&db=m Feno?brate suppresses cellular metabolic memory of high glucose in diabetic retinopathy via a sirtuin 1-dependent signalling pathway. causal interaction,unassigned 2,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30333091&form=6&db=m Serum microRNA-211 as a biomarker for diabetic retinopathy via modulating Sirtuin 1. diagnostic usage,unassigned 2,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33064974&form=6&db=m MicroRNA-34a promotes apoptosis of retinal vascular endothelial cells by targeting SIRT1 in rats with diabetic retinopathy. ongoing research,unassigned 2,0 2.3.1.286 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25940287&form=6&db=m [Rhein promotes the expression of SIRT1 in kidney tissues of type 2 diabetic rat]. causal interaction,unassigned 2,0 2.3.1.286 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24214980&form=6&db=m Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27474445&form=6&db=m SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.3.1.286 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24214980&form=6&db=m Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27474445&form=6&db=m SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.3.1.286 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30605226&form=6&db=m Sirtuin-1 in immunotherapy: A Janus-headed target. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Endodermal Sinus Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28249923&form=6&db=m Morphoproteomics Identifies the EZH2 and SIRT1 Pathways as Potential Blocks to Differentiation in Yolk Sac Tumor of the Ovary and Provides Therapeutic Options: a Case Study. causal interaction,therapeutic application,unassigned 2,3,0 2.3.1.286 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26701732&form=6&db=m Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium. causal interaction,unassigned 2,0 2.3.1.286 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30548678&form=6&db=m Suppression of microRNA-141 suppressed p53 to protect against neural apoptosis in epilepsy by SIRT1 expression. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34402260&form=6&db=m Progress on mitochondrial silence information regulator family in epilepsy. causal interaction,therapeutic application,unassigned 2,3,0 2.3.1.286 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32213139&form=6&db=m Response by Dikalova and Dikalov to Letter Regarding Article, "Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress". causal interaction,unassigned 2,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21044047&form=6&db=m Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation. causal interaction,unassigned 2,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22363635&form=6&db=m Exendin-4 Improves Steatohepatitis by Increasing Sirt1 Expression in High-Fat Diet-Induced Obese C57BL/6J Mice. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24486702&form=6&db=m SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis. ongoing research,therapeutic application,unassigned 4,2,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26098879&form=6&db=m Fructose Mediated Non-Alcoholic Fatty Liver Is Attenuated by HO-1-SIRT1 Module in Murine Hepatocytes and Mice Fed a High Fructose Diet. ongoing research,unassigned 2,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27493486&form=6&db=m Effect of Daisaikoto on Expressions of SIRT1 and NF-kappaB of Diabetic Fatty Liver Rats Induced by High-Fat Diet and Streptozotocin. ongoing research,unassigned 2,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28808064&form=6&db=m Obesity and aging diminish SIRT1-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3. ongoing research,unassigned 2,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30263038&form=6&db=m Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind randomized placebo-controlled clinical trial. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30574122&form=6&db=m Sirtuins and Insulin Resistance. causal interaction,unassigned 2,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31321239&form=6&db=m Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33794741&form=6&db=m The ménage à trois of autophagy, lipid droplets and liver disease. ongoing research,unassigned 2,0 2.3.1.286 Fatty Liver, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24262277&form=6&db=m Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver. causal interaction,ongoing research,unassigned 2,4,0 2.3.1.286 Fatty Liver, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26005675&form=6&db=m Sirtuin 1 signaling and alcoholic fatty liver disease. diagnostic usage,unassigned 2,0 2.3.1.286 Fatty Liver, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27274198&form=6&db=m The combination of blueberry juice and probiotics reduces apoptosis of alcoholic fatty liver of mice by affecting SIRT1 pathway. therapeutic application,unassigned 2,0 2.3.1.286 Fatty Liver, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28213273&form=6&db=m 2-Methoxyestradiol protects against ischemia/reperfusion injury in alcoholic fatty liver by enhancing sirtuin 1-mediated autophagy. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21898400&form=6&db=m miR-520c and miR-373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF-?B factor in human fibrosarcoma cells. causal interaction,ongoing research,unassigned 2,2,0 2.3.1.286 Gallstones http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22290433&form=6&db=m Hepatic Deletion of SIRT1 Decreases Hepatocyte Nuclear Factor 1?/Farnesoid X Receptor Signaling and Induces Formation of Cholesterol Gallstones in Mice. ongoing research,unassigned 2,0 2.3.1.286 Ganglion Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32089065&form=6&db=m Activating Sirt1 by resveratrol suppresses Nav1.7 expression in DRG through miR-182 and alleviates neuropathic pain in rats. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.3.1.286 Gastrointestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23226517&form=6&db=m 2, 3, 5, 4'-Tetrahydroxystilbene-2-O-beta-D-glucoside improves gastrointestinal motility disorders in STZ-induced diabetic mice. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33200312&form=6&db=m Evaluation of silent information regulator T (SIRT) 1 and Forkhead Box O (FOXO) transcription factor 1 and 3a genes in glaucoma. ongoing research,unassigned 2,0 2.3.1.286 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23291065&form=6&db=m [Mechanism of temozolomide-induced anti-tumor effects on glioblastoma cells in vitro is via ROS-dependent SIRT1 signaling pathway]. ongoing research,unassigned 2,0 2.3.1.286 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27340387&form=6&db=m Induction of Nuclear Enlargement and Senescence by Sirtuin Inhibitors in Glioblastoma Cells. causal interaction,therapeutic application,unassigned 2,3,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24488909&form=6&db=m FoxM1 regulates Sirt1 expression in glioma cells. causal interaction,ongoing research,unassigned 2,2,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26898440&form=6&db=m MicroRNA-132 cause apoptosis of glioma cells through blockade of the SREBP-1c metabolic pathway related to SIRT1. causal interaction,ongoing research,unassigned 2,4,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31889362&form=6&db=m Long noncoding RNA-GAS5 attenuates progression of glioma by eliminating microRNA-10b and Sirtuin 1 in U251 and A172 cells. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24163589&form=6&db=m SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and ?-cell formation. ongoing research,unassigned 2,0 2.3.1.286 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24184811&form=6&db=m Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. ongoing research,therapeutic application,unassigned 4,2,0 2.3.1.286 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28808064&form=6&db=m Obesity and aging diminish SIRT1-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3. ongoing research,unassigned 2,0 2.3.1.286 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31127273&form=6&db=m SIRT1 in Astrocytes Regulates Glucose Metabolism and Reproductive Function. ongoing research,unassigned 2,0 2.3.1.286 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34405591&form=6&db=m Muscle-specific sirtuin 3 overexpression does not attenuate the pathological effects of high-fat/high-sucrose feeding but does enhance cardiac SERCA2a activity. therapeutic application,unassigned 2,0 2.3.1.286 Glucose Metabolism Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31234024&form=6&db=m Protective effects of melatonin on sepsis-induced liver injury and dysregulation of gluconeogenesis in rats through activating SIRT1/STAT3 pathway. causal interaction,unassigned 2,0 2.3.1.286 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28558013&form=6&db=m Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia. ongoing research,unassigned 2,0 2.3.1.286 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29740774&form=6&db=m Sirtuin signaling controls mitochondrial function in glycogen storage disease type Ia. ongoing research,unassigned 2,0 2.3.1.286 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21094524&form=6&db=m Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31026620&form=6&db=m Modulation of miR-34a/SIRT1 signaling protects cochlear hair cells against oxidative stress and delays age-related hearing loss through coordinated regulation of mitophagy and mitochondrial biogenesis. causal interaction,unassigned 2,0 2.3.1.286 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31170533&form=6&db=m SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33889076&form=6&db=m Protective Effects of N1-Methylnicotinamide Against High-Fat Diet- and Age-Induced Hearing Loss via Moderate Overexpression of Sirtuin 1 Protein. diagnostic usage,therapeutic application,unassigned 2,1,0 2.3.1.286 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34507120&form=6&db=m Thymoquinone ameliorates age-related hearing loss in C57BL/6J mice by modulating Sirt1 activity and Bak1 expression. ongoing research,unassigned 2,0 2.3.1.286 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22370592&form=6&db=m Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease. ongoing research,unassigned 2,0 2.3.1.286 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23135512&form=6&db=m A sirtuin link between metabolism and heart disease. causal interaction,unassigned 2,0 2.3.1.286 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27993241&form=6&db=m Sirtuin 1 Activation Reduces Transforming Growth Factor-?1-Induced Fibrogenesis and Affords Organ Protection in a Model of Progressive, Experimental Kidney and Associated Cardiac Disease. ongoing research,unassigned 2,0 2.3.1.286 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28661724&form=6&db=m SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection. causal interaction,unassigned 2,0 2.3.1.286 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33438055&form=6&db=m Molecular mechanisms of doxorubicin-induced cardiotoxicity: novel roles of sirtuin 1-mediated signaling pathways. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22155497&form=6&db=m Non-histone lysine acetylated proteins in heart failure. causal interaction,unassigned 2,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27819129&form=6&db=m Roles of SIRT3 in heart failure: from bench to bedside. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29063982&form=6&db=m Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress. causal interaction,ongoing research,unassigned 2,2,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30786847&form=6&db=m Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca2+-ATPase in Heart Failure. causal interaction,diagnostic usage,unassigned 2,3,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33206628&form=6&db=m Sirt1 improves heart failure through modulating the NF-?B p65/microRNA-155/BNDF signaling cascade. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33569184&form=6&db=m Elevated plasma Sirtuin2 level predicts heart failure after acute myocardial infarction. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1 2.3.1.286 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31321239&form=6&db=m Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22833338&form=6&db=m Resveratrol-mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation. therapeutic application,unassigned 2,0 2.3.1.286 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26722524&form=6&db=m Expression of Sirt1 and FoxP3 in classical Hodgkin lymphoma and tumor infiltrating lymphocytes: Implications for immune dysregulation, prognosis and potential therapeutic targeting. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,3 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24046746&form=6&db=m Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. causal interaction,therapeutic application,unassigned 2,3,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24602787&form=6&db=m Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25223836&form=6&db=m Safety, pharmacokinetics, pharmacogenomics and QT concentration-effect modelling of the SirT1 inhibitor selisistat in healthy volunteers. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32524313&form=6&db=m Cerebellar Predominant Increase in mRNA Expression Levels of Sirt1 and Sirt3 Isoforms in a Transgenic Mouse Model of Huntington's Disease. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33285261&form=6&db=m Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics. causal interaction,unassigned 2,0 2.3.1.286 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32423865&form=6&db=m Antioxidant modulation of sirtuin 3 during acute inflammatory pain: The ROS control. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24163589&form=6&db=m SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and ?-cell formation. ongoing research,unassigned 2,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24454277&form=6&db=m Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1. therapeutic application,unassigned 2,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26346823&form=6&db=m Differential Telomere Shortening in Blood versus Arteries in an Animal Model of Type 2 Diabetes. causal interaction,unassigned 2,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27789474&form=6&db=m P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1. therapeutic application,unassigned 2,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30102915&form=6&db=m High glucose concentration suppresses a SIRT2 regulated pathway that enhances neurite outgrowth in cultured adult sensory neurons. causal interaction,unassigned 2,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32808479&form=6&db=m Resveratrol improves sperm DNA quality and reproductive capacity in type 1 diabetes. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34509564&form=6&db=m Up-regulation of GLP-1R improved the dysfunction of late EPCs under hyperglycemia by regulating SIRT1 expression. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20819950&form=6&db=m Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria? ongoing research,unassigned 2,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29641494&form=6&db=m Maternal Melatonin Therapy Attenuated Maternal High-Fructose Combined with Post-Weaning High-Salt Diets-Induced Hypertension in Adult Male Rat Offspring. therapeutic application,unassigned 2,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32213139&form=6&db=m Response by Dikalova and Dikalov to Letter Regarding Article, "Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress". causal interaction,unassigned 2,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33143333&form=6&db=m Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies. ongoing research,unassigned 2,0 2.3.1.286 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23151359&form=6&db=m Thyroid hormone regulation of Sirtuin 1 expression and implications to integrated responses in fasted mice. ongoing research,unassigned 2,0 2.3.1.286 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29018134&form=6&db=m Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33246465&form=6&db=m Neuroprotective epi-drugs quench the inflammatory response and microglial/macrophage activation in a mouse model of permanent brain ischemia. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28192515&form=6&db=m Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy. causal interaction,unassigned 2,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28707004&form=6&db=m Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30968966&form=6&db=m microRNA-34a aggravates coxsackievirus B3-induced apoptosis of cardiomyocytes through the SIRT1-p53 pathway. causal interaction,unassigned 2,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31898369&form=6&db=m EV71 infection induces cell apoptosis through ROS generation and SIRT1 activation. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32841684&form=6&db=m Shrimp SIRT1 activates of the WSSV IE1 promoter independently of the NF-?B binding site. ongoing research,unassigned 2,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33459133&form=6&db=m Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy. ongoing research,unassigned 2,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33531400&form=6&db=m Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33641223&form=6&db=m Helicobacter pylori inhibits autophagic flux and promotes its intracellular survival and colonization by down-regulating SIRT1. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33754030&form=6&db=m SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux. causal interaction,diagnostic usage,unassigned 2,3,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33857259&form=6&db=m The antiviral sirtuin 3 bridges protein acetylation to mitochondrial integrity and metabolism during human cytomegalovirus infection. ongoing research,unassigned 2,0 2.3.1.286 Infertility, Male http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30030567&form=6&db=m MicroRNA-34a targets sirtuin 1 and leads to diabetes-induced testicular apoptotic cell death. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28655643&form=6&db=m Activation of sirtuin 1 by catalpol-induced down-regulation of microRNA-132 attenuates endoplasmic reticulum stress in colitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27799874&form=6&db=m Enhanced Viral Replication by Cellular Replicative Senescence. therapeutic application,unassigned 2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15850715&form=6&db=m A defect in the activity of Delta6 and Delta5 desaturases may be a factor predisposing to the development of insulin resistance syndrome. causal interaction,unassigned 2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19756720&form=6&db=m Insulin signaling and life span. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20421294&form=6&db=m Macrophage {alpha}1-AMP-activated protein kinase ({alpha}1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20819950&form=6&db=m Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria? ongoing research,unassigned 2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21907137&form=6&db=m SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22078933&form=6&db=m Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation. therapeutic application,unassigned 2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22357324&form=6&db=m Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23183898&form=6&db=m The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25782776&form=6&db=m SIRT1 overexpression in skeletal muscle in vivo induces increased insulin sensitivity and enhanced complex I but not complex II-V functions in individual subsarcolemmal and intermyofibrillar mitochondria. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25849131&form=6&db=m Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25940287&form=6&db=m [Rhein promotes the expression of SIRT1 in kidney tissues of type 2 diabetic rat]. causal interaction,unassigned 2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26074075&form=6&db=m Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26637398&form=6&db=m Association of Genetic Variants of SIRT1 With Type 2 Diabetes Mellitus. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27456392&form=6&db=m Activation of the AMPK/Sirt1 pathway by a leucine-metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism and increases life span in Caenorhabditis elegans. ongoing research,unassigned 2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28270525&form=6&db=m Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue. causal interaction,ongoing research,unassigned 2,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28726069&form=6&db=m Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds. causal interaction,unassigned 2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29524414&form=6&db=m A novel SIRT1 activator E6155 improves insulin sensitivity in type 2 diabetic KKA therapeutic application,unassigned 2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30574122&form=6&db=m Sirtuins and Insulin Resistance. causal interaction,unassigned 2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30675190&form=6&db=m Probiotic assisted weight management as a main factor for glycemic control in patients with type 2 diabetes: a randomized controlled trial. diagnostic usage,unassigned 2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30809769&form=6&db=m Gastric Bypass Surgery Improves the Skeletal Muscle Ceramide/S1P Ratio and Upregulates the AMPK/ SIRT1/ PGC-1? Pathway in Zucker Diabetic Fatty Rats. causal interaction,unassigned 2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30873501&form=6&db=m The effects of trans-resveratrol on insulin resistance, inflammation, and microbiota in men with the metabolic syndrome: A pilot randomized, placebo-controlled clinical trial. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31127273&form=6&db=m SIRT1 in Astrocytes Regulates Glucose Metabolism and Reproductive Function. ongoing research,unassigned 2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31321239&form=6&db=m Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31915150&form=6&db=m Protection Against Insulin Resistance by Apolipoprotein M/Sphingosine 1-Phosphate. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32033527&form=6&db=m Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32187456&form=6&db=m Trifolium pratense (Red Clover) Improve SIRT1 Expression and Glycogen Content in High Fat Diet-Streptozotocin Induced Type 2 Diabetes in Rats. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32281435&form=6&db=m Zinc, copper, sirtuin 1 concentration, and glucose metabolism parameters in the blood of women with polycystic ovary syndrome. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33167100&form=6&db=m [Expression of Sirtuin 1 in visceral adipose tissue in Tibetan mini-pigs with obesity and insulin resistance induced by high fat/cholesterol diet]. causal interaction,ongoing research,unassigned 2,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33308015&form=6&db=m Peripheral and central regulation of insulin by the intestine and microbiome. ongoing research,unassigned 2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33390968&form=6&db=m Adipose Tissue SIRT1 Regulates Insulin Sensitizing and Anti-Inflammatory Effects of Berberine. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34256387&form=6&db=m Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity? causal interaction,unassigned 2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34379994&form=6&db=m SIRT1: a promising therapeutic target in type 2 diabetes mellitus. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34530111&form=6&db=m Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.3.1.286 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27792110&form=6&db=m Role of Sirt1 Plays in Nucleus Pulposus Cells and Intervertebral Disc Degeneration. ongoing research,unassigned 2,0 2.3.1.286 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32705163&form=6&db=m Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration. ongoing research,unassigned 2,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26058697&form=6&db=m Sirtuin 3 mediates neuroprotection of ketones against ischemic stroke. ongoing research,therapeutic application,unassigned 4,2,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33313940&form=6&db=m Long non?coding RNA H19 inhibition ameliorates oxygen?glucose deprivation?induced cell apoptosis and inflammatory cytokine expression by regulating the microRNA?29b/SIRT1/PGC?1? axis. causal interaction,unassigned 2,0 2.3.1.286 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26306884&form=6&db=m Ketosis may promote brain macroautophagy by activating Sirt1 and hypoxia-inducible factor-1. causal interaction,unassigned 2,0 2.3.1.286 Kidney Calculi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34333021&form=6&db=m Sirt1 inhibits kidney stones formation by attenuating calcium oxalate-induced cell injury. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20595677&form=6&db=m Sirtuins and their relevance to the kidney. ongoing research,unassigned 2,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32657157&form=6&db=m Role of SIRT1 in HIV-associated kidney disease. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 2.3.1.286 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31888250&form=6&db=m Novel Synthetic Approaches for Bisnaphthalimidopropyl (BNIP) Derivatives as Potential Anti-Parasitic Agents for the Treatment of Leishmaniasis. therapeutic application,unassigned 2,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21818379&form=6&db=m Synergistic Interactions between HDAC and Sirtuin Inhibitors in Human Leukemia Cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25687038&form=6&db=m [Construction of SIRT1 Promoter Expression Vector and Its Activity Analysis as well as Influence of AML1-ETO on Transcriptional Regulation of SIRT1 Gene]. diagnostic usage,ongoing research,unassigned 2,4,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28053092&form=6&db=m Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31180336&form=6&db=m SIRT1 regulates metabolism and leukemogenic potential in CML stem cells. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33199987&form=6&db=m Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.3.1.286 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32165863&form=6&db=m Sirtuin 1 inhibits lipopolysaccharide-induced inflammation in chronic myelogenous leukemia k562 cells through interacting with the Toll-like receptor 4-nuclear factor ? B-reactive oxygen species signaling axis. causal interaction,unassigned 2,0 2.3.1.286 Leukemia-Lymphoma, Adult T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33630973&form=6&db=m Deciphering microRNA-mRNA regulatory network in adult T-cell leukemia/lymphoma; the battle between oncogenes and anti-oncogenes. causal interaction,diagnostic usage,unassigned 2,2,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28919365&form=6&db=m Hepatic stellate cell-specific deletion of SIRT1 exacerbates liver fibrosis in mice. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28970250&form=6&db=m SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32324317&form=6&db=m GRHL2 induces liver fibrosis and intestinal mucosal barrier dysfunction in non-alcoholic fatty liver disease via microRNA-200 and the MAPK pathway. diagnostic usage,ongoing research,unassigned 2,3,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34480962&form=6&db=m Targeting Sirtuin1 to treat aging-related tissue fibrosis: From prevention to therapy. causal interaction,ongoing research,unassigned 2,1,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19474719&form=6&db=m Metabolic benefits from Sirt1 and Sirt1 activators. ongoing research,unassigned 2,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26005675&form=6&db=m Sirtuin 1 signaling and alcoholic fatty liver disease. diagnostic usage,unassigned 2,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26015978&form=6&db=m AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28789977&form=6&db=m Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30574122&form=6&db=m Sirtuins and Insulin Resistance. causal interaction,unassigned 2,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31234024&form=6&db=m Protective effects of melatonin on sepsis-induced liver injury and dysregulation of gluconeogenesis in rats through activating SIRT1/STAT3 pathway. causal interaction,unassigned 2,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33794741&form=6&db=m The ménage à trois of autophagy, lipid droplets and liver disease. ongoing research,unassigned 2,0 2.3.1.286 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24262277&form=6&db=m Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver. causal interaction,ongoing research,unassigned 2,4,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23162614&form=6&db=m DBC1 does not function as a negative regulator of SIRT1 in liver cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25975503&form=6&db=m HSP90 and SIRT3 expression in hepatocellular carcinoma and their effect on invasive capability of human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26967560&form=6&db=m MEK1 signaling promotes self-renewal and tumorigenicity of liver cancer stem cells via maintaining SIRT1 protein stabilization. causal interaction,unassigned 2,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28387906&form=6&db=m Facilitation of liver cancer SMCC7721 cell aging by sirtuin 4 via inhibiting JAK2/STAT3 signal pathway. ongoing research,therapeutic application,unassigned 4,2,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28583374&form=6&db=m Sirt1 suppresses Wnt/?Catenin signaling in liver cancer cells by targeting ?Catenin in a PKA?-dependent manner. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32631535&form=6&db=m Exploring the newer oxadiazoles as real inhibitors of human SIRT2 in hepatocellular cancer cells. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25415045&form=6&db=m Sirtuin 1 Activator SRT1720 Protects Against Lung Injury via Reduction of Type II Alveolar Epithelial Cells Apoptosis in Emphysema. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25973008&form=6&db=m Resveratrol attenuates spinal cord injury-induced inflammatory damage in rat lungs. diagnostic usage,unassigned 2,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26704614&form=6&db=m Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26708779&form=6&db=m Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30022154&form=6&db=m Activation of SIRT1 ameliorates LPS-induced lung injury in mice via decreasing endothelial tight junction permeability. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23162614&form=6&db=m DBC1 does not function as a negative regulator of SIRT1 in liver cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24220725&form=6&db=m Extract of Bryophyllum laetivirens reverses etoposide resistance in human lung A549 cancer cells by downregulation of NF-?B. ongoing research,unassigned 2,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24240701&form=6&db=m SIRT1 and AMPK mediate hypoxia-induced resistance of non-small cell lung cancers to cisplatin and doxorubicin. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25738249&form=6&db=m Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27501149&form=6&db=m Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer. causal interaction,unassigned 2,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30464525&form=6&db=m Resveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK. therapeutic application,unassigned 2,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32489467&form=6&db=m Cytoplasm-localized SIRT1 downregulation attenuates apoptosis and cell cycle arrest in cisplatin-resistant lung cancer A549 cells. causal interaction,unassigned 2,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32768387&form=6&db=m Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32930414&form=6&db=m A new series of benzoxazole-based SIRT1 modulators for targeted therapy of non-small-cell lung cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33655712&form=6&db=m SIRT3 promotion reduces resistance to cisplatin in lung cancer by modulating the FOXO3/CDT1 axis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,2 2.3.1.286 Lupus Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27034698&form=6&db=m The Therapeutic Effects of the Chinese Herbal Medicine, Lang Chuang Fang Granule, on Lupus-Prone MRL/lpr Mice. ongoing research,unassigned 2,0 2.3.1.286 Lupus Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32813287&form=6&db=m Accelerated, severe lupus nephritis benefits from treatment with honokiol by immunoregulation and differentially regulating NF-?B/NLRP3 inflammasome and sirtuin 1/autophagy axis. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23913470&form=6&db=m Sirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphoma. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28927798&form=6&db=m Effect of charcoal:dextran stripped fetal bovine serum on in vitro development of bovine embryos. causal interaction,unassigned 2,0 2.3.1.286 Lymphoma, T-Cell, Peripheral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25674239&form=6&db=m Morphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-?B pathways and expressions of IGF-1R, Sirt1, COX-2, and FASN in peripheral T-cell lymphomas: pathogenetic implications and therapeutic options. therapeutic application,unassigned 2,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15821341&form=6&db=m Roles of SIRT1 and phosphoinositide 3-OH kinase/protein kinase C pathways in evodiamine-induced human melanoma A375-S2 cell death. ongoing research,unassigned 2,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24850177&form=6&db=m Expression of proteins involved in epigenetic regulation in human cutaneous melanoma and peritumoral skin. ongoing research,unassigned 2,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25486469&form=6&db=m Sirtuin deacetylases: a new target for melanoma management. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31292999&form=6&db=m 4'-Bromo-resveratrol, a dual Sirtuin-1 and Sirtuin-3 inhibitor, inhibits melanoma cell growth through mitochondrial metabolic reprogramming. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,3 2.3.1.286 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31713761&form=6&db=m Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25738249&form=6&db=m Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25738249&form=6&db=m Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23636469&form=6&db=m Suppression of native defense mechanisms, SIRT1 and PPAR?, by dietary glycoxidants precedes disease in adult humans; relevance to lifestyle-engendered chronic diseases. causal interaction,diagnostic usage,unassigned 2,1,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32181656&form=6&db=m Ginsenoside Rg2 ameliorates high-fat diet-induced metabolic disease through SIRT1. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20103932&form=6&db=m Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory? therapeutic application,unassigned 2,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24702436&form=6&db=m Sirtuin 1 stabilization by HuR represses TNF-? and glucose induced E-Selectin release and endothelial cell adhesiveness in vitro. Relevance to human metabolic syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25312940&form=6&db=m AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,4,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25376184&form=6&db=m Development of a dietary-induced metabolic syndrome model using miniature pigs involvement of AMPK and SIRT1. ongoing research,unassigned 2,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29779969&form=6&db=m Increased malondialdehyde vs. reduced sirtuin 1 in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31901865&form=6&db=m The metabolic footprint during adipocyte commitment highlights ceramide modulation as an adequate approach for obesity treatment. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33924115&form=6&db=m Chronic High Fat Diet Intake Impairs Hepatic Metabolic Parameters in Ovariectomized Sirt3 KO Mice. therapeutic application,unassigned 2,0 2.3.1.286 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33269829&form=6&db=m [Effects of electroacupuncture on miR-34a-5p/SIRT1 signaling in the trigeminal ganglion of rats with migraine]. causal interaction,unassigned 2,0 2.3.1.286 Mitochondrial Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24814483&form=6&db=m NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease. ongoing research,unassigned 2,0 2.3.1.286 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655824&form=6&db=m Sirtuin 1 and oral cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 2.3.1.286 mrna m6a methyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32650237&form=6&db=m METTL3 Induces AAA Development and Progression by Modulating N6-Methyladenosine-Dependent Primary miR34a Processing. causal interaction,unassigned 2,0 2.3.1.286 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21915620&form=6&db=m The time-dependent autophagy protects against apoptosis with possible involvement of Sirt1 protein in multiple myeloma under nutrient depletion. therapeutic application,unassigned 2,0 2.3.1.286 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22783411&form=6&db=m Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33732382&form=6&db=m Targeting SIRT1 to inhibit the proliferation of multiple myeloma cells. ongoing research,unassigned 2,0 2.3.1.286 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27474445&form=6&db=m SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.3.1.286 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31812544&form=6&db=m Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26372908&form=6&db=m Differential expression of HDAC and HAT genes in atrophying skeletal muscle. ongoing research,unassigned 2,0 2.3.1.286 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30146412&form=6&db=m SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function. causal interaction,unassigned 2,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20105289&form=6&db=m Sirtuin1-p53, forkhead box O3a, p38 and post-infarct cardiac remodeling in the spontaneously diabetic Goto-Kakizaki rat. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25154304&form=6&db=m Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-?B, Sirt1 and mitogen-activated protein kinase signalling pathways and inhibition of inflammation. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27613967&form=6&db=m Polydatin protects cardiomyocytes against myocardial infarction injury by activating Sirt3. causal interaction,unassigned 2,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27981013&form=6&db=m PLGA-PNIPAM Microspheres Loaded with the Gastrointestinal Nutrient NaB Ameliorate Cardiac Dysfunction by Activating Sirt3 in Acute Myocardial Infarction. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28361889&form=6&db=m The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction. therapeutic application,unassigned 2,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29664427&form=6&db=m Effect of statins on sirtuin 1 and endothelial nitric oxide synthase expression in young patients with a history of premature myocardial infarction. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,2 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30910451&form=6&db=m Pretreatment with Tilianin improves mitochondrial energy metabolism and oxidative stress in rats with myocardial ischemia/reperfusion injury via AMPK/SIRT1/PGC-1 alpha signaling pathway. causal interaction,unassigned 2,0 2.3.1.286 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27677982&form=6&db=m Sirtinol abrogates late phase of cardiac ischemia preconditioning in rats. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Myocardial Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25871830&form=6&db=m Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D. causal interaction,ongoing research,unassigned 2,2,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23019416&form=6&db=m Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: implications for antineoplastic combination therapies. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23583181&form=6&db=m SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis. causal interaction,ongoing research,unassigned 2,3,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30016968&form=6&db=m Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30546461&form=6&db=m FK866 inhibits the epithelial-mesenchymal transition of hepatocarcinoma MHCC97-H cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31085453&form=6&db=m Resistin induces breast cancer cells epithelial to mesenchymal transition (EMT) and stemness through both adenylyl cyclase-associated protein 1 (CAP1)-dependent and CAP1-independent mechanisms. ongoing research,unassigned 2,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33640782&form=6&db=m Sulforaphane-cisplatin combination inhibits the stemness and metastatic potential of TNBCs via down regulation of sirtuins-mediated EMT signaling axis. diagnostic usage,unassigned 2,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33931868&form=6&db=m Downregulation of SUN2 promotes metastasis of colon cancer by activating BDNF/TrkB signalling by interacting with SIRT1. causal interaction,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12939617&form=6&db=m Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. causal interaction,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16288037&form=6&db=m Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17957139&form=6&db=m SIRT3 is Pro-Apoptotic and Participates in Distinct Basal Apoptotic Pathways. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18235502&form=6&db=m Negative regulation of the deacetylase SIRT1 by DBC1. ongoing research,therapeutic application,unassigned 4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18547592&form=6&db=m Adipose tissue gene expression profiles in ob/ob mice treated with leptin. causal interaction,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19132007&form=6&db=m How does SIRT1 affect metabolism, senescence and cancer? causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19268663&form=6&db=m Red wine triggers cell death and thioredoxin reductase inhibition: effects beyond resveratrol and SIRT1. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19503100&form=6&db=m SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol. ongoing research,therapeutic application,unassigned 4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19559674&form=6&db=m Identification of a small molecule SIRT2 inhibitor with selective tumor cytotoxicity. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19749416&form=6&db=m Sirtuins as Novel Targets for Alzheimer's Disease and Other Neurodegenerative Disorders: Experimental and Genetic Evidence. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20061622&form=6&db=m Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20819950&form=6&db=m Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria? ongoing research,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20975832&form=6&db=m SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53. causal interaction,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21165558&form=6&db=m Genomic organization and localization of the NAD-dependent histone deacetylase gene sirtuin 3 (Sirt3) in the mouse. causal interaction,diagnostic usage,unassigned 2,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21358671&form=6&db=m SirT3 suppresses hypoxia inducible factor 1? and tumor growth by inhibiting mitochondrial ROS production. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21941620&form=6&db=m The dual role of sirtuins in cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21947282&form=6&db=m SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. causal interaction,ongoing research,unassigned 2,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22340585&form=6&db=m aSIRTing Control over Cancer Stem Cells. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22410779&form=6&db=m SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22443029&form=6&db=m New clinical findings on the longevity gene in disease, health, & longevity: Sirtuin 1 often decreases with advanced age & serious diseases in most parts of the human body, while relatively high & constant Sirtuin 1 regardless of age was first found in the hippocampus of supercentenarians. causal interaction,diagnostic usage,unassigned 2,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22464458&form=6&db=m Novel acridinedione derivatives: design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22783411&form=6&db=m Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22833338&form=6&db=m Resveratrol-mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation. therapeutic application,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22895814&form=6&db=m Lentivirus-mediated siRNA targeting VEGF inhibits gastric cancer growth in vivo. causal interaction,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23019416&form=6&db=m Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: implications for antineoplastic combination therapies. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23162614&form=6&db=m DBC1 does not function as a negative regulator of SIRT1 in liver cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23189967&form=6&db=m Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23583181&form=6&db=m SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis. causal interaction,ongoing research,unassigned 2,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23604120&form=6&db=m Sorting out functions of sirtuins in cancer. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23811471&form=6&db=m The protein-protein interaction network of the human Sirtuin family. ongoing research,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24183459&form=6&db=m SIRT2: tumour suppressor or tumour promoter in operable breast cancer? causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24240701&form=6&db=m SIRT1 and AMPK mediate hypoxia-induced resistance of non-small cell lung cancers to cisplatin and doxorubicin. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24441046&form=6&db=m Dual role of SIRT1 in UVB-induced skin tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24681946&form=6&db=m SIRT2 regulates tumour hypoxia response by promoting HIF-1? hydroxylation. therapeutic application,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25154304&form=6&db=m Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-?B, Sirt1 and mitogen-activated protein kinase signalling pathways and inhibition of inflammation. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25312940&form=6&db=m AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25452121&form=6&db=m The role of SIRT1 in cancer: the saga continues. causal interaction,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25486469&form=6&db=m Sirtuin deacetylases: a new target for melanoma management. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25747515&form=6&db=m Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25779952&form=6&db=m SIRT1/PGC1?-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25826085&form=6&db=m Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25855962&form=6&db=m Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1? destabilization. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25898275&form=6&db=m Intersections between mitochondrial sirtuin signaling and tumor cell metabolism. causal interaction,ongoing research,unassigned 2,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25923013&form=6&db=m SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors. ongoing research,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26074075&form=6&db=m Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26420067&form=6&db=m New SIRT1 activator from alkaline hydrolysate of total saponins in the stems-leaves of Panax ginseng. diagnostic usage,ongoing research,unassigned 2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26689352&form=6&db=m 1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells. ongoing research,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26722524&form=6&db=m Expression of Sirt1 and FoxP3 in classical Hodgkin lymphoma and tumor infiltrating lymphocytes: Implications for immune dysregulation, prognosis and potential therapeutic targeting. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26961318&form=6&db=m Sirtuin inhibitors: An overview from medicinal chemistry perspective. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27496874&form=6&db=m Expression of sirtuins 1, 6, tumor necrosis factor, and interferon-? in psoriatic patients. diagnostic usage,ongoing research,unassigned 2,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28249923&form=6&db=m Morphoproteomics Identifies the EZH2 and SIRT1 Pathways as Potential Blocks to Differentiation in Yolk Sac Tumor of the Ovary and Provides Therapeutic Options: a Case Study. causal interaction,therapeutic application,unassigned 2,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28346398&form=6&db=m Sirtuin 1 (Sirt1) Overexpression in BaF3 Cells Contributes to Cell Proliferation Promotion, Apoptosis Resistance and Pro-Inflammatory Cytokine Production. causal interaction,diagnostic usage,unassigned 2,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28428276&form=6&db=m Micellar Delivery of miR-34a Modulator Rubone and Paclitaxel in Resistant Prostate Cancer. ongoing research,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28661724&form=6&db=m SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection. causal interaction,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29564694&form=6&db=m Differential gene expression of sirtuins between somatotropinomas and nonfunctioning pituitary adenomas. causal interaction,diagnostic usage,unassigned 2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29701897&form=6&db=m SIRT1 attenuates murine allergic rhinitis by downregulated HMGB 1/TLR4 pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30263038&form=6&db=m Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind randomized placebo-controlled clinical trial. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30519106&form=6&db=m Tumor-suppressive function of SIRT4 in neuroblastoma through mitochondrial damage. causal interaction,ongoing research,unassigned 2,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30546461&form=6&db=m FK866 inhibits the epithelial-mesenchymal transition of hepatocarcinoma MHCC97-H cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655824&form=6&db=m Sirtuin 1 and oral cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30835165&form=6&db=m Sirt2 Regulates Radiation-Induced Injury. causal interaction,ongoing research,unassigned 2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30870650&form=6&db=m Pharmacophore modeling and virtual screening studies to identify novel selective SIRT2 inhibitors. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31085453&form=6&db=m Resistin induces breast cancer cells epithelial to mesenchymal transition (EMT) and stemness through both adenylyl cyclase-associated protein 1 (CAP1)-dependent and CAP1-independent mechanisms. ongoing research,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31159195&form=6&db=m Epac1 and Glycyrrhizin Both Inhibit HMGB1 Levels to Reduce Diabetes-Induced Neuronal and Vascular Damage in the Mouse Retina. diagnostic usage,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31445496&form=6&db=m Aqueous Extract of Whitmania Pigra Whitman Alleviates Thrombus Burden via Sirtuin 1/NF-?B Pathway. diagnostic usage,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31726691&form=6&db=m Enzymatic and Biological Characterization of Novel Sirtuin Modulators against Cancer. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31961433&form=6&db=m The signaling pathways implicated in impairment of hepatic autophagy in glycogen storage disease type Ia. ongoing research,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32035228&form=6&db=m Mechanistic understanding of ?-cryptoxanthin and lycopene in cancer prevention in animal models. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32117717&form=6&db=m Impact of Sirtuin Enzymes on the Altered Metabolic Phenotype of Malignantly Transformed Cells. causal interaction,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32134743&form=6&db=m SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32244715&form=6&db=m Sirt3 Exerts Its Tumor-Suppressive Role by Increasing p53 and Attenuating Response to Estrogen in MCF-7 Cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32768387&form=6&db=m Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32820458&form=6&db=m Axonal Protection by Nicotinamide Riboside via SIRT1-Autophagy Pathway in TNF-Induced Optic Nerve Degeneration. diagnostic usage,ongoing research,unassigned 2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33627431&form=6&db=m The deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early tumorigenesis. causal interaction,diagnostic usage,unassigned 2,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33655712&form=6&db=m SIRT3 promotion reduces resistance to cisplatin in lung cancer by modulating the FOXO3/CDT1 axis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33766523&form=6&db=m IL-1? induces expression of proinflammatory cytokines and migration of human colon cancer cells through upregulation of SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33889076&form=6&db=m Protective Effects of N1-Methylnicotinamide Against High-Fat Diet- and Age-Induced Hearing Loss via Moderate Overexpression of Sirtuin 1 Protein. diagnostic usage,therapeutic application,unassigned 2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33923297&form=6&db=m SIRT1-Dependent Upregulation of BDNF in Human Microglia Challenged with A?: An Early but Transient Response Rescued by Melatonin. causal interaction,diagnostic usage,unassigned 2,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34119591&form=6&db=m Lipopolysaccharide-induced depression is associated with estrogen receptor-?/SIRT1/NF-?B signaling pathway in old female mice. diagnostic usage,unassigned 2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34135317&form=6&db=m VHL regulates the sensitivity of clear cell renal cell carcinoma to SIRT4-mediated metabolic stress via HIF-1?/HO-1 pathway. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34310804&form=6&db=m Silent information regulator 2 promotes clear cell renal cell carcinoma progression through deacetylation and small ubiquitin-related modifier 1 modification of glucose 6-phosphate dehydrogenase. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,1 2.3.1.286 Nephrolithiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34333021&form=6&db=m Sirt1 inhibits kidney stones formation by attenuating calcium oxalate-induced cell injury. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0 2.3.1.286 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29018134&form=6&db=m Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29393101&form=6&db=m Resveratrol Promotes Recovery of Hearing following Intense Noise Exposure by Enhancing Cochlear SIRT1 Activity. therapeutic application,unassigned 2,0 2.3.1.286 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31713761&form=6&db=m Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27646435&form=6&db=m miR-124a and miR-155 enhance differentiation of regulatory T cells in patients with neuropathic pain. causal interaction,diagnostic usage,unassigned 2,1,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32089065&form=6&db=m Activating Sirt1 by resveratrol suppresses Nav1.7 expression in DRG through miR-182 and alleviates neuropathic pain in rats. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.3.1.286 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29609003&form=6&db=m Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells. ongoing research,unassigned 2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18400158&form=6&db=m Paths of convergence: sirtuins in aging and neurodegeneration. causal interaction,unassigned 2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19355928&form=6&db=m Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection. causal interaction,therapeutic application,unassigned 2,3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19749416&form=6&db=m Sirtuins as Novel Targets for Alzheimer's Disease and Other Neurodegenerative Disorders: Experimental and Genetic Evidence. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20061622&form=6&db=m Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20446769&form=6&db=m CELLULAR STRESS RESPONSES, THE HORMESIS PARADIGM AND VITAGENES: NOVEL TARGETS FOR THERAPEUTIC INTERVENTION IN NEURODEGENERATIVE DISORDERS. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22108204&form=6&db=m Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22749331&form=6&db=m The neurobiology of sirtuins and their role in neurodegeneration. causal interaction,therapeutic application,unassigned 2,3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23410123&form=6&db=m Sirtuins as Possible Targets in Neurodegenerative Diseases. ongoing research,unassigned 2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23530512&form=6&db=m Resveratrol:New Avenues For A Natural Compound In Neuroprotection. ongoing research,unassigned 2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25312940&form=6&db=m AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31016762&form=6&db=m Eriodictyol alleviates lipopolysaccharide-triggered oxidative stress and synaptic dysfunctions in BV-2 microglial cells and mouse brain. causal interaction,unassigned 2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31812544&form=6&db=m Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32727328&form=6&db=m SIRT1 promotes neuronal fortification in neurodegenerative diseases through attenuation of pathological hallmarks and enhancement of cellular lifespan. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33285261&form=6&db=m Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics. causal interaction,unassigned 2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34356626&form=6&db=m Cognitive Impairment and Dementia: Gaining Insight through Circadian Clock Gene Pathways. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26384348&form=6&db=m Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28466267&form=6&db=m 17?-Estradiol via SIRT1/Acetyl-p53/NF-kB Signaling Pathway Rescued Postnatal Rat Brain Against Acute Ethanol Intoxication. therapeutic application,unassigned 2,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28551846&form=6&db=m AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia. causal interaction,unassigned 2,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31016762&form=6&db=m Eriodictyol alleviates lipopolysaccharide-triggered oxidative stress and synaptic dysfunctions in BV-2 microglial cells and mouse brain. causal interaction,unassigned 2,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31812544&form=6&db=m Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Nijmegen Breakage Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612497&form=6&db=m SIRT1 regulates the function of the Nijmegen breakage syndrome protein. therapeutic application,unassigned 2,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19474719&form=6&db=m Metabolic benefits from Sirt1 and Sirt1 activators. ongoing research,unassigned 2,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24947350&form=6&db=m SIRT1 Mediates the Effect of GLP-1 Receptor Agonist Exenatide on Ameliorating Hepatic Steatosis. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26015978&form=6&db=m AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26146507&form=6&db=m Hugan Qingzhi Exerts Anti-Inflammatory Effects in a Rat Model of Nonalcoholic Fatty Liver Disease. ongoing research,unassigned 2,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27174364&form=6&db=m Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing. causal interaction,ongoing research,unassigned 2,3,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28789977&form=6&db=m Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29581157&form=6&db=m Regulation of Mitochondrial Trifunctional Protein Modulates Nonalcoholic Fatty Liver Disease in Mice. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29727630&form=6&db=m Theacrine protects against nonalcoholic fatty liver disease by regulating acylcarnitine metabolism. causal interaction,unassigned 2,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30263038&form=6&db=m Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind randomized placebo-controlled clinical trial. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32324317&form=6&db=m GRHL2 induces liver fibrosis and intestinal mucosal barrier dysfunction in non-alcoholic fatty liver disease via microRNA-200 and the MAPK pathway. diagnostic usage,ongoing research,unassigned 2,3,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32918742&form=6&db=m Differential TM4SF5-mediated SIRT1 modulation and metabolic signaling in nonalcoholic steatohepatitis progression. causal interaction,unassigned 2,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33794741&form=6&db=m The ménage à trois of autophagy, lipid droplets and liver disease. ongoing research,unassigned 2,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34088068&form=6&db=m Cadmium chloride induces non-alcoholic fatty liver disease in rats by stimulating miR-34a/SIRT1/FXR/p53 axis. causal interaction,unassigned 2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19474719&form=6&db=m Metabolic benefits from Sirt1 and Sirt1 activators. ongoing research,unassigned 2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20421294&form=6&db=m Macrophage {alpha}1-AMP-activated protein kinase ({alpha}1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21907137&form=6&db=m SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24717514&form=6&db=m Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25330910&form=6&db=m SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling. ongoing research,unassigned 2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25479240&form=6&db=m Brown Alga Ecklonia cava Polyphenol Extract Ameliorates Hepatic Lipogenesis, Oxidative Stress, and Inflammation by Activation of AMPK and SIRT1 in High-Fat Diet-Induced Obese Mice. causal interaction,unassigned 2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25849131&form=6&db=m Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26074075&form=6&db=m Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27181590&form=6&db=m Neurodegeneration Alters Metabolic Profile and Sirt 1 Signaling in High-Fat-Induced Obese Mice. ongoing research,unassigned 2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28808064&form=6&db=m Obesity and aging diminish SIRT1-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3. ongoing research,unassigned 2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30203196&form=6&db=m Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30574122&form=6&db=m Sirtuins and Insulin Resistance. causal interaction,unassigned 2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31302001&form=6&db=m SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism. causal interaction,ongoing research,unassigned 2,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31302199&form=6&db=m Epithelial sodium channels in endothelial cells mediate diet-induced endothelium stiffness and impaired vascular relaxation in obese female mice. causal interaction,unassigned 2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31321239&form=6&db=m Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31901865&form=6&db=m The metabolic footprint during adipocyte commitment highlights ceramide modulation as an adequate approach for obesity treatment. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32982666&form=6&db=m Environment and Gene Association With Obesity and Their Impact on Neurodegenerative and Neurodevelopmental Diseases. causal interaction,unassigned 2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33167100&form=6&db=m [Expression of Sirtuin 1 in visceral adipose tissue in Tibetan mini-pigs with obesity and insulin resistance induced by high fat/cholesterol diet]. causal interaction,ongoing research,unassigned 2,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33854178&form=6&db=m SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34405591&form=6&db=m Muscle-specific sirtuin 3 overexpression does not attenuate the pathological effects of high-fat/high-sucrose feeding but does enhance cardiac SERCA2a activity. therapeutic application,unassigned 2,0 2.3.1.286 Obesity, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21306556&form=6&db=m SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae. ongoing research,unassigned 2,0 2.3.1.286 Optic Nerve Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23821198&form=6&db=m SIRT1 promotes RGC survival and delays loss of function following optic nerve crush. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.3.1.286 Optic Neuritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23821198&form=6&db=m SIRT1 promotes RGC survival and delays loss of function following optic nerve crush. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.3.1.286 Oral Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34007301&form=6&db=m The Anti-Inflammatory Effect of Zhibaidihuang Decoction on Recurrent Oral Ulcer with Sirt1 as the Key Regulatory Target. therapeutic application,unassigned 2,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24184155&form=6&db=m Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/?-catenin activity. ongoing research,unassigned 2,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25737402&form=6&db=m Intra-articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF-2? therapeutic application,unassigned 2,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26902093&form=6&db=m Reduced Sirtuin1 expression at the femoral neck in women who sustained an osteoporotic hip fracture. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,3,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28213268&form=6&db=m Fisetin inhibits IL-1?-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28255111&form=6&db=m [Sirtuin type 1 signaling pathway mediates the effect of diosgenin on chondrocyte metabolisms in osteoarthritis]. ongoing research,unassigned 2,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31223428&form=6&db=m Curcumin Inhibits the PERK-eIF2?-CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32271403&form=6&db=m SIRT2 inhibits oxidative stress and inflammatory response in diabetic osteoarthritis. causal interaction,therapeutic application,unassigned 2,3,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32499111&form=6&db=m Epigenetic regulation of chondrocyte hypertrophy and apoptosis through Sirt1/P53/P21 pathway in surgery-induced osteoarthritis. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32665267&form=6&db=m Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence. diagnostic usage,unassigned 2,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33927645&form=6&db=m Protective Effect of SIRT1 Activator on the Knee With Osteoarthritis. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34184072&form=6&db=m Sulforaphane protects against oxidative stress?induced apoptosis via activating SIRT1 in mouse osteoarthritis. therapeutic application,unassigned 2,0 2.3.1.286 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27890623&form=6&db=m SIRT1 protects osteoblasts against particle-induced inflammatory responses and apoptosis in aseptic prosthesis loosening. therapeutic application,unassigned 2,0 2.3.1.286 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29775898&form=6&db=m Particle-induced SIRT1 downregulation promotes osteoclastogenesis and osteolysis through ER stress regulation. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.3.1.286 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31943384&form=6&db=m Hydrogen sulfide protects against particle-induced inflammatory response and osteolysis via SIRT1 pathway in prosthesis loosening. ongoing research,therapeutic application,unassigned 1,2,0 2.3.1.286 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33817415&form=6&db=m Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3?/?-catenin signalling pathway. ongoing research,therapeutic application,unassigned 4,2,0 2.3.1.286 Osteonecrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34260898&form=6&db=m Therapeutic effect of SIRT3 on glucocorticoid-induced osteonecrosis of femoral head via intracellular oxidative suppression. ongoing research,therapeutic application,unassigned 1,2,0 2.3.1.286 Osteophyte http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27367673&form=6&db=m The NAD-Dependent Deacetylase Sirtuin-1 Regulates the Expression of Osteogenic Transcriptional Activator Runt-Related Transcription Factor 2 (Runx2) and Production of Matrix Metalloproteinase (MMP)-13 in Chondrocytes in Osteoarthritis. ongoing research,unassigned 2,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19591274&form=6&db=m [Sir2 gene] causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26902093&form=6&db=m Reduced Sirtuin1 expression at the femoral neck in women who sustained an osteoporotic hip fracture. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,3,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29201210&form=6&db=m Protective effects of resveratrol on osteoporosis via activation of the SIRT1-NF-?B signaling pathway in rats. therapeutic application,unassigned 2,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33781770&form=6&db=m Effect of resveratrol and mesenchymal stem cell monotherapy and combined treatment in management of osteoporosis in ovariectomized rats: Role of SIRT1/FOXO3a and Wnt/?-catenin pathways. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23877372&form=6&db=m MicroRNA-126 inhibits osteosarcoma cells proliferation by targeting Sirt1. ongoing research,unassigned 2,0 2.3.1.286 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29248694&form=6&db=m Sirt3 confers protection against acrolein-induced oxidative stress in cochlear nucleus neurons. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29580688&form=6&db=m SIRT3 aggravates metformin-induced energy stress and apoptosis in ovarian cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Overnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29783682&form=6&db=m Heat Shock Gene Inactivation and Protein Aggregation with Links to Chronic Diseases. ongoing research,unassigned 2,0 2.3.1.286 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27160497&form=6&db=m Diminished levels of regulatory T cell subsets (CD8+Foxp3, CD4+Foxp3 and CD4+CD39+Foxp3) but increased Foxp3 expression in adipose tissue from overweight subjects. diagnostic usage,ongoing research,unassigned 2,4,0 2.3.1.286 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30037068&form=6&db=m Gene Expression of Sirtuin-1 and Endogenous Secretory Receptor for Advanced Glycation End Products in Healthy and Slightly Overweight Subjects after Caloric Restriction and Resveratrol Administration. diagnostic usage,ongoing research,unassigned 2,4,0 2.3.1.286 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32033527&form=6&db=m Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32586268&form=6&db=m Combined high-intensity interval training and green tea supplementation enhance metabolic and antioxidant status in response to acute exercise in overweight women. therapeutic application,unassigned 2,0 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25965392&form=6&db=m Ectopic expression of miR-494 inhibited the proliferation, invasion and chemoresistance of pancreatic cancer by regulating SIRT1 and c-Myc. ongoing research,unassigned 2,0 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26655844&form=6&db=m SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31055719&form=6&db=m Association of Serum Levels of Silent Information Regulator 1 with Persistent Organ Failure in Acute Pancreatitis. diagnostic usage,unassigned 2,0 2.3.1.286 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33628394&form=6&db=m Resveratrol Suppresses Severe Acute Pancreatitis-Induced Microcirculation Disturbance through Targeting SIRT1-FOXO1 Axis. therapeutic application,unassigned 2,0 2.3.1.286 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34363008&form=6&db=m A novel resveratrol analog upregulates sirtuin 1 and inhibits inflammatory cell infiltration in acute pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 2.3.1.286 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19503100&form=6&db=m SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol. ongoing research,therapeutic application,unassigned 4,2,0 2.3.1.286 Papillomavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32664381&form=6&db=m Regulation of the Human Papillomavirus Life Cycle by DNA Damage Repair Pathways and Epigenetic Factors. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24046746&form=6&db=m Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. causal interaction,therapeutic application,unassigned 2,3,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31812544&form=6&db=m Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32134743&form=6&db=m SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.3.1.286 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32159972&form=6&db=m Depletion of microRNA-451 in response to allergen exposure accentuates asthmatic inflammation by regulating Sirtuin2. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26339397&form=6&db=m Expression of SIRT1 in the ovaries of rats with polycystic ovary syndrome before and after therapeutic intervention with exenatide. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32281435&form=6&db=m Zinc, copper, sirtuin 1 concentration, and glucose metabolism parameters in the blood of women with polycystic ovary syndrome. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Prediabetic State http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29779969&form=6&db=m Increased malondialdehyde vs. reduced sirtuin 1 in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 2.3.1.286 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32552911&form=6&db=m Effects of perinatal factors on sirtuin 3, 8-hydroxy-2'- deoxyguanosine, brain-derived neurotrophic factor and serotonin in cord blood and early breast milk: an observational study. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25452121&form=6&db=m The role of SIRT1 in cancer: the saga continues. causal interaction,unassigned 2,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25870236&form=6&db=m MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition. therapeutic application,unassigned 2,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27686228&form=6&db=m The UCA1/miR-204/Sirt1 axis modulates docetaxel sensitivity of prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33788729&form=6&db=m Expression Patterns of ER?, ER?, AR, SIRT1, SIRT2, and SIRT3 in Prostate Cancer Tissue and Normal Prostate Tissue. diagnostic usage,ongoing research,unassigned 2,3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20335659&form=6&db=m Sirt1 activation protects the mouse renal medulla from oxidative injury. ongoing research,unassigned 2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21083429&form=6&db=m SIRT1 Deficiency Downregulates PTEN/JNK/FOXO1 Pathway to Block ROS-Induced Apoptosis in Mouse Embryonic Stem Cells. causal interaction,unassigned 2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22290433&form=6&db=m Hepatic Deletion of SIRT1 Decreases Hepatocyte Nuclear Factor 1?/Farnesoid X Receptor Signaling and Induces Formation of Cholesterol Gallstones in Mice. ongoing research,unassigned 2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22645641&form=6&db=m Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis. causal interaction,unassigned 2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25035926&form=6&db=m Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy. therapeutic application,unassigned 2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25555707&form=6&db=m SIRT3 Attenuates MPTP-Induced Nigrostriatal Degeneration Via Enhancing Mitochondrial Antioxidant Capacity. causal interaction,unassigned 2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27501149&form=6&db=m Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer. causal interaction,unassigned 2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27722009&form=6&db=m Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity. causal interaction,unassigned 2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28579116&form=6&db=m SIRT3 prevents angiotensin II-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29440391&form=6&db=m SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis. causal interaction,ongoing research,unassigned 2,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30146412&form=6&db=m SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function. causal interaction,unassigned 2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32181656&form=6&db=m Ginsenoside Rg2 ameliorates high-fat diet-induced metabolic disease through SIRT1. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33371209&form=6&db=m A Sex-Specific Role of Endothelial Sirtuin 3 on Blood Pressure and Diastolic Dysfunction in Female Mice. ongoing research,unassigned 2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33542782&form=6&db=m Protective Effects of Oroxylin A against Doxorubicin-Induced Cardiotoxicity via the Activation of Sirt1 in Mice. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33754030&form=6&db=m SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux. causal interaction,diagnostic usage,unassigned 2,3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33981977&form=6&db=m Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneys. causal interaction,ongoing research,unassigned 2,2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34180125&form=6&db=m Sirtuin 3 deficiency aggravates angiotensin II-induced hypertensive cardiac injury by the impairment of lymphangiogenesis. causal interaction,unassigned 2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34368883&form=6&db=m Oxymatrine attenuates oxidized low?density lipoprotein?induced HUVEC injury by inhibiting NLRP3 inflammasome?mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathway. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34394832&form=6&db=m Oxypaeoniflorin Prevents Acute Lung Injury Induced by Lipopolysaccharide through the PTEN/AKT Pathway in a Sirt1-Dependent Manner. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24141423&form=6&db=m Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,2 2.3.1.286 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21715244&form=6&db=m Abnormal histone modifications in PBMCs from patients with psoriasis vulgaris. diagnostic usage,unassigned 2,0 2.3.1.286 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27496874&form=6&db=m Expression of sirtuins 1, 6, tumor necrosis factor, and interferon-? in psoriatic patients. diagnostic usage,ongoing research,unassigned 2,3,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27559927&form=6&db=m Shelterin TPP1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirt1 Deacetylase in Chronic Obstructive Pulmonary Disease. causal interaction,unassigned 2,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29138552&form=6&db=m SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients. diagnostic usage,unassigned 2,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31510839&form=6&db=m Curcumin ameliorates chronic obstructive pulmonary disease by modulating autophagy and endoplasmic reticulum stress through regulation of SIRT1 in a rat model. ongoing research,unassigned 2,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32504994&form=6&db=m 3,4,5-Trihydroxycinnamic acid exerts a protective effect on pulmonary inflammation in an experimental animal model of COPD. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25973008&form=6&db=m Resveratrol attenuates spinal cord injury-induced inflammatory damage in rat lungs. diagnostic usage,unassigned 2,0 2.3.1.286 Relative Energy Deficiency in Sport http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29862271&form=6&db=m Beneficial Effects of Concentrated Growth Factors and Resveratrol on Human Osteoblasts In Vitro Treated with Bisphosphonates. diagnostic usage,ongoing research,unassigned 2,4,0 2.3.1.286 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31492107&form=6&db=m Spironolactone ameliorates endothelial dysfunction through inhibition of the AGE/RAGE axis in a chronic renal failure rat model. causal interaction,unassigned 2,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25871830&form=6&db=m Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D. causal interaction,ongoing research,unassigned 2,2,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26489513&form=6&db=m SIRT1 protects against myocardial ischemia-reperfusion injury via activating eNOS in diabetic rats. causal interaction,unassigned 2,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27677982&form=6&db=m Sirtinol abrogates late phase of cardiac ischemia preconditioning in rats. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27819129&form=6&db=m Roles of SIRT3 in heart failure: from bench to bedside. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30776367&form=6&db=m MicroRNA-30c abrogation protects against spinal cord ischemia reperfusion injury through modulating SIRT1. causal interaction,therapeutic application,unassigned 2,3,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31481517&form=6&db=m Inhibiting microRNA-29a protects myocardial ischemia-reperfusion injury by targeting SIRT1 and regulating NLRP3 and apoptosis pathway. therapeutic application,unassigned 2,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31865720&form=6&db=m Resveratrol increase myocardial Nrf2 expression in type 2 diabetic rats and alleviate myocardial ischemia/reperfusion injury (MIRI). causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32695008&form=6&db=m Hydrogen Sulfide Ameliorates Lung Ischemia-Reperfusion Injury Through SIRT1 Signaling Pathway in Type 2 Diabetic Rats. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33480219&form=6&db=m Muscone alleviates myocardial ischemia-reperfusion injury via inhibition of oxidative stress and enhancement of SIRT3. therapeutic application,unassigned 2,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33935765&form=6&db=m Danggui-Shaoyao-San (DSS) Ameliorates Cerebral Ischemia-Reperfusion Injury via Activating SIRT1 Signaling and Inhibiting NADPH Oxidases. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34292112&form=6&db=m Quercetin attenuates ischemia reperfusion injury by protecting the blood-brain barrier through Sirt1 in MCAO rats. causal interaction,therapeutic application,unassigned 2,3,0 2.3.1.286 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32732457&form=6&db=m PARP1 Impedes SIRT1-Mediated Autophagy during Degeneration of the Retinal Pigment Epithelium under Oxidative Stress. causal interaction,unassigned 2,0 2.3.1.286 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29701897&form=6&db=m SIRT1 attenuates murine allergic rhinitis by downregulated HMGB 1/TLR4 pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32361418&form=6&db=m Resveratrol-mediated SIRT1 activation attenuates ovalbumin-induced allergic rhinitis in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.3.1.286 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32541149&form=6&db=m HIF1? Deficiency in Dendritic Cells Attenuates Symptoms and Inflammatory Indicators of Allergic Rhinitis in a SIRT1-Dependent Manner. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Sarcopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19591274&form=6&db=m [Sir2 gene] causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23625030&form=6&db=m Resveratrol reduces acute lung injury in a LPS?induced sepsis mouse model via activation of Sirt1. ongoing research,therapeutic application,unassigned 4,2,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25356114&form=6&db=m Interleukin 6 increases dysfunction of organs in sepsis rats through sirtuin 1. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26704614&form=6&db=m Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28503576&form=6&db=m Sirtuin 2 Regulates Microvascular Inflammation during Sepsis. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28993270&form=6&db=m Reduced silent information regulator 1 signaling exacerbates sepsis-induced myocardial injury and mitigates the protective effect of a liver X receptor agonist. ongoing research,unassigned 2,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30203196&form=6&db=m Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30216989&form=6&db=m Sirtuins and Immuno-Metabolism of Sepsis. causal interaction,ongoing research,unassigned 2,1,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31234024&form=6&db=m Protective effects of melatonin on sepsis-induced liver injury and dysregulation of gluconeogenesis in rats through activating SIRT1/STAT3 pathway. causal interaction,unassigned 2,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32538180&form=6&db=m Sevoflurane attenuates cognitive dysfunction and NLRP3-dependent caspase-1/11-GSDMD pathway-mediated pyroptosis in the hippocampus via upregulation of SIRT1 in a sepsis model. causal interaction,unassigned 2,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33968038&form=6&db=m Ghrelin Alleviates Intestinal Dysfunction in Sepsis Through the KLF4/MMP2 Regulatory Axis by Activating SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.3.1.286 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23499872&form=6&db=m The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock. therapeutic application,unassigned 2,0 2.3.1.286 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24441046&form=6&db=m Dual role of SIRT1 in UVB-induced skin tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33095054&form=6&db=m SIRT1-mediated deacetylation of NF-?B inhibits the MLCK/MLC2 pathway and the expression of ET-1, thus alleviating the development of coronary artery spasm. therapeutic application,unassigned 2,0 2.3.1.286 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30816451&form=6&db=m SIRT1 inhibits apoptosis in in vivo and in vitro models of spinal cord injury via microRNA-494. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Spinal Cord Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30776367&form=6&db=m MicroRNA-30c abrogation protects against spinal cord ischemia reperfusion injury through modulating SIRT1. causal interaction,therapeutic application,unassigned 2,3,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23151359&form=6&db=m Thyroid hormone regulation of Sirtuin 1 expression and implications to integrated responses in fasted mice. ongoing research,unassigned 2,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28434941&form=6&db=m Dysregulation of the SIRT1/OCT6 Axis Contributes to Environmental Stress-Induced Neural Induction Defects. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22895814&form=6&db=m Lentivirus-mediated siRNA targeting VEGF inhibits gastric cancer growth in vivo. causal interaction,unassigned 2,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25761483&form=6&db=m Forkhead Transcription Factor FOXO1 Inhibits Angiogenesis in Gastric Cancer in Relation to SIRT1. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30029680&form=6&db=m Regulation of tNOX expression through the ROS-p53-POU3F2 axis contributes to cellular responses against oxaliplatin in human colon cancer cells. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27041235&form=6&db=m A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia. therapeutic application,unassigned 2,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29018134&form=6&db=m Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29302794&form=6&db=m Evaluation of the Neuroprotective Effect of Sirt3 in Experimental Stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,3 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33664650&form=6&db=m Neuroprotective Effects of Exercise Postconditioning After Stroke via SIRT1-Mediated Suppression of Endoplasmic Reticulum (ER) Stress. causal interaction,unassigned 2,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34371139&form=6&db=m c-myc protects mice from ischemia stroke through elevating microRNA-200b-5p-regulated SIRT1 expression. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.286 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31076789&form=6&db=m SIRT1 Activation: A Potential Strategy for Harnessing Endogenous Protection Against Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29540553&form=6&db=m SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy. ongoing research,unassigned 2,0 2.3.1.286 Teratoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24936455&form=6&db=m SIRT1 Is Necessary for Proficient Telomere Elongation and Genomic Stability of Induced Pluripotent Stem Cells. causal interaction,unassigned 2,0 2.3.1.286 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25142464&form=6&db=m SirT1 is required in the male germ cell for differentiation and fecundity in mice. ongoing research,unassigned 2,0 2.3.1.286 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32212452&form=6&db=m [Advances in the studies of teratospermia-related genes]. therapeutic application,unassigned 2,0 2.3.1.286 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26705390&form=6&db=m BDNFVal66met polymorphism: a potential bridge between depression and thrombosis. diagnostic usage,ongoing research,unassigned 2,2,0 2.3.1.286 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31445496&form=6&db=m Aqueous Extract of Whitmania Pigra Whitman Alleviates Thrombus Burden via Sirtuin 1/NF-?B Pathway. diagnostic usage,unassigned 2,0 2.3.1.286 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23846322&form=6&db=m Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells. therapeutic application,unassigned 2,0 2.3.1.286 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30876970&form=6&db=m Cyanidin-3-glucoside induces mesenchymal to epithelial transition via activating Sirt1 expression in triple negative breast cancer cells. ongoing research,unassigned 2,0 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23553634&form=6&db=m Cyclic AMP-dependent protein lysine acylation in mycobacteria regulates fatty acid and propionate metabolism. ongoing research,unassigned 2,0 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27242704&form=6&db=m Phosphorylation Modulates Catalytic Activity of Mycobacterial Sirtuins. ongoing research,unassigned 2,0 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28707004&form=6&db=m Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33459133&form=6&db=m Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy. ongoing research,unassigned 2,0 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33531400&form=6&db=m Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31088250&form=6&db=m Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice. causal interaction,unassigned 2,0 2.3.1.286 ulp1 peptidase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31302001&form=6&db=m SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism. causal interaction,ongoing research,unassigned 2,3,0 2.3.1.286 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20335659&form=6&db=m Sirt1 activation protects the mouse renal medulla from oxidative injury. ongoing research,unassigned 2,0 2.3.1.286 Vascular Calcification http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23268970&form=6&db=m [Molecular mechanism of vascular calcification: essential role of mammalian sirtuin SIRT1 in cellular senescence]. causal interaction,unassigned 2,0 2.3.1.286 Vascular Calcification http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30829051&form=6&db=m Peroxisome Proliferator-Activated Receptor-? Coactivator-1? Inhibits Vascular Calcification Through Sirtuin 3-Mediated Reduction of Mitochondrial Oxidative Stress. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.286 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24702436&form=6&db=m Sirtuin 1 stabilization by HuR represses TNF-? and glucose induced E-Selectin release and endothelial cell adhesiveness in vitro. Relevance to human metabolic syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 2.3.1.286 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31463647&form=6&db=m Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects. ongoing research,unassigned 2,0 2.3.1.286 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32982786&form=6&db=m The Role of Sirtuin-1 in the Vasculature: Focus on Aortic Aneurysm. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,2,0 2.3.1.286 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33117155&form=6&db=m Histone Deacetylase SIRT1, Smooth Muscle Cell Function, and Vascular Diseases. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.286 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27799874&form=6&db=m Enhanced Viral Replication by Cellular Replicative Senescence. therapeutic application,unassigned 2,0 2.3.1.286 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20103932&form=6&db=m Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory? therapeutic application,unassigned 2,0 2.3.1.286 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21416250&form=6&db=m Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.3.1.286 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24441046&form=6&db=m Dual role of SIRT1 in UVB-induced skin tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.3.1.286 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28943955&form=6&db=m p53 inhibits the upregulation of sirtuin 1 expression induced by c-Myc. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25386563&form=6&db=m Renal protective effect of sirtuin 1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30442253&form=6&db=m Dexmedetomidine attenuation of renal ischaemia-reperfusion injury requires sirtuin 3 activation. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32210821&form=6&db=m SIRT1 Mediates Effects of FGF21 to Ameliorate Cisplatin-Induced Acute Kidney Injury. ongoing research,unassigned 3,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33513830&form=6&db=m Intestinal SIRT1 Deficiency-Related Intestinal Inflammation and Dysbiosis Aggravate TNF?-Mediated Renal Dysfunction in Cirrhotic Ascitic Mice. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33779856&form=6&db=m Activators of SIRT1 in the kidney and protective effects of SIRT1 during acute kidney injury (AKI) (effect of SIRT1 activators on acute kidney injury). ongoing research,unassigned 3,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26884869&form=6&db=m Inhibition of acute lung injury by rubriflordilactone in LPS-induced rat model through suppression of inflammatory factor expression. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31520990&form=6&db=m Suppression of NLRP3 and NF-?B signaling pathways by ?-Cyperone via activating SIRT1 contributes to attenuation of LPS-induced acute lung injury in mice. ongoing research,unassigned 3,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33215523&form=6&db=m Resveratrol alleviates alveolar epithelial cell injury induced by hyperoxia by reducing apoptosis and mitochondrial dysfunction. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22554968&form=6&db=m Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24088390&form=6&db=m High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27494892&form=6&db=m Sirtuin1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31656671&form=6&db=m Immunohistochemistry and clinical value of sirtuin 2 in non-metastasized non-small cell lung cancer. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31723239&form=6&db=m Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33341453&form=6&db=m Cellular molecular and proteomic profiling deciphers the SIRT1 controlled cell death pathways in esophageal adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34112288&form=6&db=m [Effects of resveratrol-mediated inhibition of NOD-like receptor protein 3 inflammasomevia activating silent information regulator 1 on the injury of intestinal mucosal barrier function after sepsis]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 2.3.1.286 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19649206&form=6&db=m Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24798868&form=6&db=m Inhibition of SIRT1 signaling sensitizes the antitumor activity of silybin against human lung adenocarcinoma cells in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30021836&form=6&db=m Sirt1 protects from K-Ras-driven lung carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.3.1.286 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24247792&form=6&db=m SIRT1 is a useful biomarker for high-grade dysplasia and carcinoma in Barrett's esophagus. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 2.3.1.286 Adrenal Cortex Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33650791&form=6&db=m SIRT1 is involved in adrenocortical cancer growth and motility. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24952428&form=6&db=m In vivo RNA interference models of inducible and reversible Sirt1 knockdown in kidney cells. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26083654&form=6&db=m Sirtuin and metabolic kidney disease. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29477240&form=6&db=m Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16751189&form=6&db=m Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18987186&form=6&db=m Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. therapeutic application,unassigned 3,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21826702&form=6&db=m Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling. causal interaction,unassigned 3,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21879449&form=6&db=m The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22416232&form=6&db=m Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22651940&form=6&db=m The SIRT2 polymorphism rs10410544 and risk of Alzheimer's disease in two Caucasian case-control cohorts. diagnostic usage,therapeutic application,unassigned 3,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24139700&form=6&db=m SIRT2 polymorphism rs10410544 is associated with Alzheimer's disease in a Han Chinese population. causal interaction,unassigned 3,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24142524&form=6&db=m Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27482292&form=6&db=m A Label-free Sirtuin 1 Assay based on Droplet-Electrospray Ionization Mass Spectrometry. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27522594&form=6&db=m Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27614878&form=6&db=m SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29855513&form=6&db=m SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30185534&form=6&db=m Reduced expression of SIRT1 and SOD-1 and the correlation between these levels in various regions of the brains of patients with Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30233076&form=6&db=m SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30416425&form=6&db=m Sirtuins in Neuroendocrine Regulation and Neurological Diseases. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30460524&form=6&db=m Intracerebroventricular injection of resveratrol ameliorated A?-induced learning and cognitive decline in mice. ongoing research,unassigned 3,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30514854&form=6&db=m A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32269528&form=6&db=m Noninvasive 40-Hz Light Flicker Rescues Circadian Behavior and Abnormal Lipid Metabolism Induced by Acute Ethanol Exposure via Improving SIRT1 and the Circadian Clock in the Liver-Brain Axis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33444675&form=6&db=m Nutraceutical based SIRT3 activators as therapeutic targets in Alzheimer's disease. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24252177&form=6&db=m Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25608039&form=6&db=m The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28744004&form=6&db=m Sirt1 negatively regulates Fc?RI-mediated mast cell activation through AMPK- and PTP1B-dependent processes. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Anemia, Aplastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31141802&form=6&db=m Sirt1 in the Regulation of Interferon Gamma in Severe Aplastic Anemia. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Aneurysm, Dissecting http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26376991&form=6&db=m Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Anhedonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28778545&form=6&db=m SIRT2 inhibition reverses anhedonia in the VGLUT1+/- depression model. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Anosmia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30661205&form=6&db=m Recovery of Olfactory Function After Excitotoxic Lesion of the Olfactory Bulbs Is Associated with Increases in Bulbar SIRT1 and SIRT4 Expressions. causal interaction,unassigned 3,0 2.3.1.286 Aortic Valve Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31677538&form=6&db=m Modulatory Role of SIRT1 and Resistin as Therapeutic Targets in Patients with Aortic Valve Stenosis. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Apnea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25011510&form=6&db=m [The expression of SIRT1 in brainstem of rats in different types of hypoxia and its significance]. ongoing research,unassigned 3,0 2.3.1.286 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21305533&form=6&db=m TNF?-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes. causal interaction,unassigned 3,0 2.3.1.286 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23104101&form=6&db=m Seven sirtuins for seven deadly diseases of aging. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24211200&form=6&db=m Sirt2 suppresses inflammatory responses in collagen-induced arthritis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26298564&form=6&db=m Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29355701&form=6&db=m Helicobacter pylori infection increases sirt2 gene expression in gastric epithelial cells of gastritis patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24211200&form=6&db=m Sirt2 suppresses inflammatory responses in collagen-induced arthritis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Arthritis, Gouty http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31367941&form=6&db=m Sirt1 inhibits gouty arthritis via activating PPAR?. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24746477&form=6&db=m Sirt1 activity in peripheral blood mononuclear cells from patients with rheumatoid arthritis. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25126750&form=6&db=m Inhibition of HMGB1-induced angiogenesis by cilostazol via SIRT1 activation in synovial fibroblasts from rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26298564&form=6&db=m Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27289467&form=6&db=m The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27763638&form=6&db=m 1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28638677&form=6&db=m Changes in sirtuin 2 and sirtuin 3 mRNA expressions in rheumatoid arthritis. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32191778&form=6&db=m Retraction: Inhibition of HMGB1-Induced Angiogenesis by Cilostazol via SIRT1 Activation in Synovial Fibroblasts from Rheumatoid Arthritis. causal interaction,unassigned 3,0 2.3.1.286 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23062010&form=6&db=m Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30668546&form=6&db=m Sirtuin 2 enhances allergic asthmatic inflammation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31210330&form=6&db=m Effects of SIRT1/Akt pathway on chronic inflammatory response and lung function in patients with asthma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.3.1.286 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27165717&form=6&db=m Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.3.1.286 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29590107&form=6&db=m Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites. therapeutic application,unassigned 3,0 2.3.1.286 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33273545&form=6&db=m SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18482975&form=6&db=m SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19581416&form=6&db=m TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20418343&form=6&db=m SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21042583&form=6&db=m ApoE-/- PGC-1?-/- Mice Display Reduced IL-18 Levels and Do Not Develop Enhanced Atherosclerosis. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23075766&form=6&db=m SIRT1 regulates CD40 expression induced by TNF-? via NF-?B pathway in endothelial cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23734259&form=6&db=m Regulation of SIRT1 in vascular smooth muscle cells from streptozotocin-diabetic rats. causal interaction,unassigned 3,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23754392&form=6&db=m Ca2+/calmodulin-dependent protein kinase kinase ? phosphorylation of Sirtuin 1 in endothelium is atheroprotective. causal interaction,unassigned 3,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24603306&form=6&db=m The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression. ongoing research,unassigned 3,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24859347&form=6&db=m The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26296466&form=6&db=m The Sirt1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE?/? mice through inhibiting vascular inflammatory response. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28606256&form=6&db=m [Sirt1 inhibited oxidized low-density lipoprotein induced smooth muscle cells inflammatory response]. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28881659&form=6&db=m SIRT1 inhibition promotes atherosclerosis through impaired autophagy. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28888894&form=6&db=m Exercise intervention attenuates hyperhomocysteinemia-induced aortic endothelial oxidative injury by regulating SIRT1 through mitigating NADPH oxidase/LOX-1 signaling. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29115493&form=6&db=m miR-92a regulates the expression levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 3 via sirtuin 1 signaling in hydrogen peroxide-induced vascular smooth muscle cells. therapeutic application,unassigned 3,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29343087&form=6&db=m Sulfhydrated Sirtuin-1 Increasing Its Deacetylation Activity Is an Essential Epigenetics Mechanism of Anti-Atherogenesis by Hydrogen Sulfide. causal interaction,unassigned 3,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30483753&form=6&db=m MicroRNA-140-5p aggravates hypertension and oxidative stress of atherosclerosis via targeting Nrf2 and Sirt2. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33239236&form=6&db=m Impairment of sirtuin 1-mediated DNA repair is involved in bisphenol A-induced aggravation of macrophage inflammation and atherosclerosis. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33639613&form=6&db=m Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34181898&form=6&db=m Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26952538&form=6&db=m Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31680473&form=6&db=m Protective mechanism of SIRT1 on Hcy-induced atrial fibrosis mediated by TRPC3. causal interaction,diagnostic usage,unassigned 3,1,0 2.3.1.286 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24386389&form=6&db=m Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24570024&form=6&db=m SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosus. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25890999&form=6&db=m Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology. causal interaction,unassigned 3,0 2.3.1.286 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32485674&form=6&db=m Decreased SIRT1 expression in the peripheral blood of patients with Graves' disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 2.3.1.286 Bacteremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24386389&form=6&db=m Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24386389&form=6&db=m Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25586484&form=6&db=m Effects of Resveratrol on the Treatment of Inflammatory Response Induced by Severe Burn. causal interaction,unassigned 3,0 2.3.1.286 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24247792&form=6&db=m SIRT1 is a useful biomarker for high-grade dysplasia and carcinoma in Barrett's esophagus. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 2.3.1.286 Bone Diseases, Metabolic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26928655&form=6&db=m Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice. causal interaction,unassigned 3,0 2.3.1.286 Bone Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30579931&form=6&db=m SIRT1 activation by SRT1720 attenuates bone cancer pain via preventing Drp1-mediated mitochondrial fission. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20803525&form=6&db=m SIRT1 modulates high-mobility group box 1-induced osteoclastogenic cytokines in human periodontal ligament cells. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30318050&form=6&db=m Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30862606&form=6&db=m Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders? causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,4 2.3.1.286 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31006177&form=6&db=m Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1. therapeutic application,unassigned 3,0 2.3.1.286 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33110391&form=6&db=m SIRT1/FOXO3a axis plays an important role in the prevention of mandibular bone loss induced by 1,25(OH)2D deficiency. ongoing research,unassigned 3,0 2.3.1.286 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18221243&form=6&db=m Modulation of sirtuins: new targets for antiageing. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24482345&form=6&db=m SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22204321&form=6&db=m NAD+ Metabolism and NAD+-Dependent Enzymes: Promising Therapeutic Targets for Neurological Diseases. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26594596&form=6&db=m Melatonin Counteracts at a Transcriptional Level the Inflammatory and Apoptotic Response Secondary to Ischemic Brain Injury Induced by Middle Cerebral Artery Blockade in Aging Rats. diagnostic usage,unassigned 3,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26620563&form=6&db=m SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY. therapeutic application,unassigned 3,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27991597&form=6&db=m Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury. causal interaction,unassigned 3,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28053989&form=6&db=m SIRT3 Expression Decreases with Reactive Oxygen Species Generation in Rat Cortical Neurons during Early Brain Injury Induced by Experimental Subarachnoid Hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28356158&form=6&db=m Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29872034&form=6&db=m Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH). ongoing research,therapeutic application,unassigned 4,3,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31102754&form=6&db=m Sirt1 improves functional recovery by regulating autophagy of astrocyte and neuron after brain injury. diagnostic usage,therapeutic application,unassigned 3,2,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32848564&form=6&db=m Will Sirtuins Be Promising Therapeutic Targets for TBI and Associated Neurodegenerative Diseases? causal interaction,unassigned 3,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33345851&form=6&db=m Oleanolic acid exerts neuroprotective effects in subarachnoid hemorrhage rats through SIRT1-mediated HMGB1 deacetylation. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26546505&form=6&db=m SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-?B p65 acetylation and activation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30416425&form=6&db=m Sirtuins in Neuroendocrine Regulation and Neurological Diseases. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31102754&form=6&db=m Sirt1 improves functional recovery by regulating autophagy of astrocyte and neuron after brain injury. diagnostic usage,therapeutic application,unassigned 3,2,0 2.3.1.286 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33830639&form=6&db=m Sirtuin 1 alleviates neuroinflammation-induced apoptosis after traumatic brain injury. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,3,0 2.3.1.286 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34102645&form=6&db=m SIRT2 inhibition exacerbates p53-mediated ferroptosis in mice following experimental traumatic brain injury. ongoing research,therapeutic application,unassigned 3,3,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23855981&form=6&db=m New role of silent information regulator 1 in cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25608039&form=6&db=m The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25634315&form=6&db=m SIRT1 attenuates severe ischemic damage by preserving cerebral blood flow. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26522013&form=6&db=m Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27131779&form=6&db=m Nrf2/antioxidant defense pathway is involved in the neuroprotective effects of Sirt1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27796760&form=6&db=m Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28396174&form=6&db=m Sirt3 confers protection against neuronal ischemia by inducing autophagy: Involvement of the AMPK-mTOR pathway. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29434685&form=6&db=m Salidroside attenuates hypoxia/reoxygenation-induced human brain vascular smooth muscle cell injury by activating the SIRT1/FOXO3? pathway. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30067864&form=6&db=m Protective effects of ex-527 on cerebral ischemia-reperfusion injury through necroptosis signaling pathway attenuation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32500353&form=6&db=m Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1?/VEGF Signaling and Blood-Brain Barrier Integrity. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32809175&form=6&db=m Luteolin Protects Against CIRI, Potentially via Regulation of the SIRT3/AMPK/mTOR Signaling Pathway. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17954562&form=6&db=m Nicotinamide uncouples hormone-dependent chromatin remodeling from transcription complex assembly. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19047049&form=6&db=m Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19649206&form=6&db=m Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20813094&form=6&db=m Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22190494&form=6&db=m The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23169992&form=6&db=m SIRT1 represses estrogen-signaling, ligand-independent ER?-mediated transcription, and cell proliferation in estrogen-responsive breast cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23845782&form=6&db=m Molecular characterization, alternative splicing and expression analysis of bovine DBC1. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24019980&form=6&db=m Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24415752&form=6&db=m Deleted in breast cancer 1 (DBC1) protein regulates hepatic gluconeogenesis. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25139823&form=6&db=m High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25395356&form=6&db=m The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25411356&form=6&db=m SRT1720 induces lysosomal-dependent cell death of breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25445714&form=6&db=m Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts. ongoing research,unassigned 3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25556440&form=6&db=m 4-Hydroxynonenal promotes growth and angiogenesis of breast cancer cells through HIF-1? stabilization. causal interaction,unassigned 3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26236947&form=6&db=m AMPK inhibits MTDH expression via GSK3? and SIRT1 activation: potential role in triple negative breast cancer cell proliferation. ongoing research,unassigned 3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26416354&form=6&db=m Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26928655&form=6&db=m Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice. causal interaction,unassigned 3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27345396&form=6&db=m O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway. causal interaction,unassigned 3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27503926&form=6&db=m SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27621036&form=6&db=m Brachyury promotes tamoxifen resistance in breast cancer by targeting SIRT1. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27783945&form=6&db=m The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer. diagnostic usage,unassigned 3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28781618&form=6&db=m MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28845527&form=6&db=m Extracellular NAMPT/visfatin causes p53 deacetylation via NAD production and SIRT1 activation in breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29683756&form=6&db=m De novo expression of transfected sirtuin 3 enhances susceptibility of human MCF-7 breast cancer cells to hyperoxia treatment. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29713184&form=6&db=m Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,1 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30093977&form=6&db=m SIRT1-dependent epigenetic regulation of H3 and H4 histone acetylation in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30217020&form=6&db=m A New Synthetic Histone Deacetylase Inhibitor, MHY2256, Induces Apoptosis and Autophagy Cell Death in Endometrial Cancer Cells via p53 Acetylation. ongoing research,therapeutic application,unassigned 3,3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30319549&form=6&db=m SIRT1 in Secretory Organ Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30414146&form=6&db=m Characterization of FOXO Acetylation. ongoing research,therapeutic application,unassigned 2,3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31087297&form=6&db=m Assessment of SIRT2 Inhibitors in Mouse Models of Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31261609&form=6&db=m The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31418154&form=6&db=m Upregulated tumor sirtuin 2 expression correlates with reduced TNM stage and better overall survival in surgical breast cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31746308&form=6&db=m High Expression of SIRT1 Associates with the Doxorubicin Resistance of Breast Cancer through Activating of Akt. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,3 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32547094&form=6&db=m SRC Promotes Tamoxifen Resistance in Breast Cancer via Up-Regulating SIRT1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32681437&form=6&db=m Expression of SIRT1, SIRT3 and SIRT6 Genes for Predicting Survival in Triple-Negative and Hormone Receptor-Positive Subtypes of Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32911193&form=6&db=m Development of activity-based probes for the protein deacylase Sirt1. diagnostic usage,ongoing research,unassigned 3,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34094830&form=6&db=m Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34216621&form=6&db=m Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34377766&form=6&db=m miR-301 regulates the SIRT1/SOX2 pathway via CPEB1 in the breast cancer progression. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.286 Bronchopulmonary Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27916095&form=6&db=m [Decreased SIRT1 expression is related to bronchopulmonary dysplasia in premature infants after oxygen exposure]. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Candidiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28634345&form=6&db=m Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16618762&form=6&db=m Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. causal interaction,unassigned 3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16909107&form=6&db=m SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17624472&form=6&db=m Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19657230&form=6&db=m p30 DBC is a potential regulator of tumorigenesis. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20179424&form=6&db=m Sirt1 and cell migration. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21117229&form=6&db=m Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21472714&form=6&db=m Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. causal interaction,unassigned 3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21505241&form=6&db=m Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1. causal interaction,unassigned 3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21527554&form=6&db=m Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21698133&form=6&db=m SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22554968&form=6&db=m Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22589271&form=6&db=m SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22674009&form=6&db=m Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22867969&form=6&db=m SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23272146&form=6&db=m Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23275008&form=6&db=m ?-Cryptoxanthin Restores Nicotine-Reduced Lung SIRT1 to Normal Levels and Inhibits Nicotine-Promoted Lung Tumorigenesis and Emphysema in A/J Mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23726949&form=6&db=m SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23728341&form=6&db=m MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24020002&form=6&db=m SIRT1: Regulator of p53 Deacetylation. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24085778&form=6&db=m Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice. ongoing research,unassigned 3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24127549&form=6&db=m Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24161395&form=6&db=m Sirt2 suppresses glioma cell growth through targeting NF-?B-miR-21 axis. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25003320&form=6&db=m SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages. causal interaction,unassigned 3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25109285&form=6&db=m Sirt1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,2 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25199460&form=6&db=m Docosahexaenoic acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon epithelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25332769&form=6&db=m SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis. causal interaction,unassigned 3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25380034&form=6&db=m Modulation of tumorigenesis by dietary intervention is not mediated by SIRT1 catalytic activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25746104&form=6&db=m Multifaceted Modulation of SIRT1 in Cancer and Inflammation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25785061&form=6&db=m The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25791281&form=6&db=m Gene expression mapping of histone deacetylases and co-factors, and correlation with survival time and 1H-HRMAS metabolomic profile in human gliomas. causal interaction,diagnostic usage,unassigned 3,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26303530&form=6&db=m Group IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26544624&form=6&db=m Enhancement of NAD+-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial cells. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26612257&form=6&db=m miR-543 promotes gastric cancer cell proliferation by targeting SIRT1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26646449&form=6&db=m SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27708228&form=6&db=m SIRT1-mediated downregulation of p27Kip1 is essential for overcoming contact inhibition of Kaposi's sarcoma-associated herpesvirus transformed cells. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28061480&form=6&db=m Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28259910&form=6&db=m Reduced expression of SIRT2 in serous ovarian carcinoma promotes cell proliferation through disinhibition of CDK4 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28721811&form=6&db=m Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28903430&form=6&db=m Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius guentheri. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29476819&form=6&db=m Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29683756&form=6&db=m De novo expression of transfected sirtuin 3 enhances susceptibility of human MCF-7 breast cancer cells to hyperoxia treatment. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29694890&form=6&db=m Infection Reveals a Modification of SIRT2 Critical for Chromatin Association. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29927593&form=6&db=m Hepatotoxic Effects of Hexafluoropropylene Oxide Trimer Acid (HFPO-TA), A Novel Perfluorooctanoic Acid (PFOA) Alternative, on Mice. diagnostic usage,unassigned 3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29928130&form=6&db=m Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer. causal interaction,unassigned 3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30016782&form=6&db=m Regulation of Apoptosis and Radiation Sensitization in Lung Cancer Cells via the Sirt1/NF-?B/Smac Pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30021836&form=6&db=m Sirt1 protects from K-Ras-driven lung carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30506951&form=6&db=m Circular RNA hsa_circ_0076248 promotes oncogenesis of glioma by sponging miR-181a to modulate SIRT1 expression. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30710424&form=6&db=m Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells. diagnostic usage,therapeutic application,unassigned 3,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30993888&form=6&db=m SIRT3 elicited an anti-Warburg effect through HIF1?/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31087297&form=6&db=m Assessment of SIRT2 Inhibitors in Mouse Models of Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31201813&form=6&db=m SIRT1 downregulated FGB expression to inhibit RCC tumorigenesis by destabilizing STAT3. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31285783&form=6&db=m SIRT7 Regulates Lipopolysaccharide-Induced Inflammatory Injury by Suppressing the NF-?B Signaling Pathway. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31970087&form=6&db=m Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet. ongoing research,therapeutic application,unassigned 1,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32154934&form=6&db=m SIRT1 regulates N6 -methyladenosine RNA modification in hepatocarcinogenesis by inducing RANBP2-dependent FTO SUMOylation. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32276460&form=6&db=m ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32487610&form=6&db=m Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-?B Pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32528869&form=6&db=m SIRT7 Is a Prognostic Biomarker Associated With Immune Infiltration in Luminal Breast Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33164623&form=6&db=m The possible role of Sirtuins and microRNAs in hepatocellular carcinoma therapy. diagnostic usage,unassigned 3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33327875&form=6&db=m Sirtuin 2 in Endometrial Cancer: A Potential Regulator for Cell Proliferation, Apoptosis and RAS/ERK Pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33453243&form=6&db=m SIRT1, a promising regulator of bone homeostasis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33727672&form=6&db=m MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34147543&form=6&db=m Trending topics of SIRT1 in tumorigenicity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34303869&form=6&db=m Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17806102&form=6&db=m Function of the SIRT1 protein deacetylase in cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19649206&form=6&db=m Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21117229&form=6&db=m Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22674009&form=6&db=m Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23028940&form=6&db=m SIRT1 regulates endothelial Notch signaling in lung cancer. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23045412&form=6&db=m Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23125225&form=6&db=m Effects of limiting energy availability via diet and physical activity on mammalian target of rapamycin-related signaling in rat mammary carcinomas. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23354305&form=6&db=m Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau. causal interaction,unassigned 3,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24019980&form=6&db=m Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24247792&form=6&db=m SIRT1 is a useful biomarker for high-grade dysplasia and carcinoma in Barrett's esophagus. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25005846&form=6&db=m SIRT3 is a novel prognostic biomarker for esophageal squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,3,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25794641&form=6&db=m Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25922660&form=6&db=m SIRT1 expression is associated with lymphangiogenesis, lymphovascular invasion and prognosis in pN0 esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25973238&form=6&db=m Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26499759&form=6&db=m MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27114304&form=6&db=m Mitochondrial Sirt3 supports cell proliferation by regulating glutamine-dependent oxidation in renal cell carcinoma. ongoing research,unassigned 3,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28259910&form=6&db=m Reduced expression of SIRT2 in serous ovarian carcinoma promotes cell proliferation through disinhibition of CDK4 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28653878&form=6&db=m Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29512733&form=6&db=m Autophagy inhibition enhanced 5?FU?induced cell death in human gastric carcinoma BGC?823 cells. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29625788&form=6&db=m Clinicopathological and predictive significance of SIRT1 and peroxisome proliferator-activated receptor gamma in esophageal squamous cell carcinoma: The correlation with EGFR and Survivin. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29713184&form=6&db=m Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,1 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29767533&form=6&db=m Sirtuin-1 Controls Poly (I:C)-Dependent Matrix Metalloproteinase 9 Activation in Primary Human Nasal Epithelial Cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30021836&form=6&db=m Sirt1 protects from K-Ras-driven lung carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30237737&form=6&db=m Associations of sirtuins with clinicopathological parameters and prognosis in non-small cell lung cancer. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30319549&form=6&db=m SIRT1 in Secretory Organ Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30373873&form=6&db=m Morphoproteomics and Biomedical Analytics Identify the c-Myc, EZH2, Sirt1 and CXCR4 Pathways as Potential Blocks to Differentiation Leading to Proliferation and Metastatic Potential in Sinonasal Undifferentiated Carcinoma (SNUC) and Provide Therapeutic Options: A Case Study. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31261609&form=6&db=m The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31276230&form=6&db=m Calycosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31656671&form=6&db=m Immunohistochemistry and clinical value of sirtuin 2 in non-metastasized non-small cell lung cancer. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31677030&form=6&db=m SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31781300&form=6&db=m Determination of SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, and RAGE rs1800625 Single Gene Polymorphisms in Patients with Laryngeal Squamous Cell Carcinoma. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32124989&form=6&db=m Mitochondrial Sirtuins in Skin and Skin Cancers. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32158696&form=6&db=m Integrative Analysis of Sirtuins and Their Prognostic Significance in Clear Cell Renal Cell Carcinoma. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32340156&form=6&db=m Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32846774&form=6&db=m Expression of SIRT1 and survivin correlates with poor prognosis in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.3.1.286 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32124989&form=6&db=m Mitochondrial Sirtuins in Skin and Skin Cancers. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21527554&form=6&db=m Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22562294&form=6&db=m Hepatitis B virus X (HBX) protein upregulates ?-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22609775&form=6&db=m Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23272146&form=6&db=m Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23542177&form=6&db=m SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23728341&form=6&db=m MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23827175&form=6&db=m Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes. causal interaction,unassigned 3,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24774224&form=6&db=m Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25427918&form=6&db=m The effect of alcohol on Sirt1 expression and function in animal and human models of hepatocellular carcinoma (HCC). diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28347248&form=6&db=m SIRT3 functions as a tumor suppressor in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28677784&form=6&db=m MicroRNA-138 inhibits cell proliferation in hepatocellular carcinoma by targeting Sirt1. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28992545&form=6&db=m Downregulation of SIRT2 Inhibits Invasion of Hepatocellular Carcinoma by Inhibiting Energy Metabolism. causal interaction,ongoing research,unassigned 3,3,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29152116&form=6&db=m microRNA-526b servers as a prognostic factor and exhibits tumor suppressive property by targeting Sirtuin 7 in hepatocellular carcinoma. diagnostic usage,unassigned 3,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29499851&form=6&db=m Effect of nutrient deprivation on the expression and the epigenetic signature of sirtuin genes. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29713184&form=6&db=m Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,1 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30901096&form=6&db=m Sirtuin-1/Mitochondrial Ribosomal Protein S5 Axis Enhances the Metabolic Flexibility of Liver Cancer Stem Cells. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30958623&form=6&db=m Downregulation of sirtuin 3 by palmitic acid increases the oxidative stress, impairment of mitochondrial function, and apoptosis in liver cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31040695&form=6&db=m SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-?B pathway. causal interaction,unassigned 3,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31306909&form=6&db=m Antiproliferative activity of (R)-4'-methylklavuzon on hepatocellular carcinoma cells and EpCAM+/CD133+ cancer stem cells via SIRT1 and Exportin-1 (CRM1) inhibition. ongoing research,unassigned 3,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32072026&form=6&db=m An insulin-inducible transcription factor, SHARP-1, represses transcription of the SIRT1 longevity gene. ongoing research,therapeutic application,unassigned 4,3,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32306906&form=6&db=m Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33162823&form=6&db=m Emerging Roles of SIRT1 in Alcoholic Liver Disease. diagnostic usage,unassigned 3,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33220273&form=6&db=m Sirtuin 1 and 2 inhibitors enhance the inhibitory effect of sorafenib in hepatocellular carcinoma cells. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33854041&form=6&db=m Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis. diagnostic usage,therapeutic application,unassigned 3,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34188177&form=6&db=m Novel CDK9 inhibitor oroxylin A promotes wild-type P53 stability and prevents hepatocellular carcinoma progression by disrupting both MDM2 and SIRT1 signaling. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23028940&form=6&db=m SIRT1 regulates endothelial Notch signaling in lung cancer. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24042441&form=6&db=m SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non-small cell lung cancer cells through deacetylation of NMNAT2. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24379401&form=6&db=m A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer. therapeutic application,unassigned 3,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25143434&form=6&db=m SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29957526&form=6&db=m X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30021836&form=6&db=m Sirt1 protects from K-Ras-driven lung carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30710424&form=6&db=m Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells. diagnostic usage,therapeutic application,unassigned 3,1,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31656671&form=6&db=m Immunohistochemistry and clinical value of sirtuin 2 in non-metastasized non-small cell lung cancer. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33777209&form=6&db=m MicroRNA-217 inhibits the proliferation and invasion, and promotes apoptosis of non-small cell lung cancer cells by targeting sirtuin 1. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27793057&form=6&db=m Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.3.1.286 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26499759&form=6&db=m MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27114304&form=6&db=m Mitochondrial Sirt3 supports cell proliferation by regulating glutamine-dependent oxidation in renal cell carcinoma. ongoing research,unassigned 3,0 2.3.1.286 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29713184&form=6&db=m Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,1 2.3.1.286 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32158696&form=6&db=m Integrative Analysis of Sirtuins and Their Prognostic Significance in Clear Cell Renal Cell Carcinoma. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32340156&form=6&db=m Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19649206&form=6&db=m Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23354305&form=6&db=m Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau. causal interaction,unassigned 3,0 2.3.1.286 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25794641&form=6&db=m Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 2.3.1.286 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30237737&form=6&db=m Associations of sirtuins with clinicopathological parameters and prognosis in non-small cell lung cancer. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31656671&form=6&db=m Immunohistochemistry and clinical value of sirtuin 2 in non-metastasized non-small cell lung cancer. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31677030&form=6&db=m SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3 2.3.1.286 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32124989&form=6&db=m Mitochondrial Sirtuins in Skin and Skin Cancers. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.286 Cardio-Renal Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31355422&form=6&db=m SIRT1 gene polymorphisms are associated with nondiabetic type 1 cardiorenal syndrome. causal interaction,unassigned 3,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16687393&form=6&db=m Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha. causal interaction,unassigned 3,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19652361&form=6&db=m Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23086477&form=6&db=m The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23297412&form=6&db=m Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27016702&form=6&db=m SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27393852&form=6&db=m SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27790619&form=6&db=m SIRT3 in Cardiac Physiology and Disease. causal interaction,unassigned 3,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28804553&form=6&db=m Sirt3 attenuates doxorubicin-induced cardiac hypertrophy and mitochondrial dysfunction via suppression of Bnip3. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28947430&form=6&db=m SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30677512&form=6&db=m Fibroblast growth factor 21 protects the heart from angiotensin II-induced cardiac hypertrophy and dysfunction via SIRT1. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31936371&form=6&db=m Sirtuin 3 Activation by Honokiol Decreases Unilateral Ureteral Obstruction-Induced Renal Inflammation and Fibrosis via Regulation of Mitochondrial Dynamics and the Renal NF-?BTGF-?1/Smad Signaling Pathway. therapeutic application,unassigned 3,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32018211&form=6&db=m High content screening identifies licoisoflavone A as a bioactive compound of Tongmaiyangxin Pills to restrain cardiomyocyte hypertrophy via activating Sirt3. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32139662&form=6&db=m SIRT3 inhibits cardiac hypertrophy by regulating PARP-1 activity. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34113795&form=6&db=m The association between left ventricular mass index and serum sirtuin 3 level in patients with hypertension. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34257705&form=6&db=m Ginkgolide B Protects Cardiomyocytes from Angiotensin II-Induced Hypertrophy via Regulation of Autophagy through SIRT1-FoxO1. therapeutic application,unassigned 3,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34518478&form=6&db=m Activation of SIRT1 by Resveratrol Alleviates Pressure Overload-Induced Cardiac Hypertrophy via Suppression of TGF-?1 Signaling. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34537933&form=6&db=m The protective effects of 17-? estradiol and SIRT1 against cardiac hypertrophy: a review. ongoing research,therapeutic application,unassigned 2,3,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21633959&form=6&db=m Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC-1? by PRMT1 and SIRT1. causal interaction,unassigned 3,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23297412&form=6&db=m Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24614171&form=6&db=m ?-Lapachone Ameliorates Lipotoxic Cardiomyopathy in Acyl CoA Synthase Transgenic Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25239805&form=6&db=m Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction. causal interaction,ongoing research,unassigned 3,3,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26112889&form=6&db=m Protective effects of sirtuins in cardiovascular diseases: from bench to bedside. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26730840&form=6&db=m SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26873966&form=6&db=m Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in Mice. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28724806&form=6&db=m Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29535452&form=6&db=m ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30355082&form=6&db=m Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20089851&form=6&db=m Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26873966&form=6&db=m Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in Mice. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28804553&form=6&db=m Sirt3 attenuates doxorubicin-induced cardiac hypertrophy and mitochondrial dysfunction via suppression of Bnip3. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31552474&form=6&db=m Sirt3 promotes sensitivity to sunitinib-induced cardiotoxicity via inhibition of GTSP1/JNK/autophagy pathway in vivo and in vitro. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32958254&form=6&db=m Adiponectin agonist ADP355 ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and oxidative stress. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19756718&form=6&db=m Cardiovascular determinants of life span. diagnostic usage,unassigned 3,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21054562&form=6&db=m Distribution of the longevity gene product, SIRT1, in developing mouse organs. causal interaction,unassigned 3,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21719763&form=6&db=m Sirtuin 1 retards hyperphosphatemia-induced calcification of vascular smooth muscle cells. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22185448&form=6&db=m Targeting cardiovascular disease with novel SIRT1 pathways. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22479251&form=6&db=m MicroRNA Regulation of SIRT1. causal interaction,unassigned 3,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23075334&form=6&db=m Sirtuins and renal diseases: relationship with aging and diabetic nephropathy. causal interaction,unassigned 3,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23104101&form=6&db=m Seven sirtuins for seven deadly diseases of aging. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23361587&form=6&db=m Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,4 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24247822&form=6&db=m Role of sirtuins in kidney disease. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25213338&form=6&db=m Silent information regulator 2 homolog 1 counters cerebral hypoperfusion injury by deacetylating endothelial nitric oxide synthase. ongoing research,therapeutic application,unassigned 2,3,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25386563&form=6&db=m Renal protective effect of sirtuin 1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26226216&form=6&db=m Activation of PPAR alpha by fenofibrate inhibits apoptosis in vascular adventitial fibroblasts partly through SIRT1-mediated deacetylation of FoxO1. causal interaction,unassigned 3,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26345325&form=6&db=m Effect of Nasal CPAP on SIRT1 and Endothelial Function in Obstructive Sleep Apnea Syndrome. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26928655&form=6&db=m Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice. causal interaction,unassigned 3,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27393852&form=6&db=m SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27841908&form=6&db=m Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28419207&form=6&db=m CKII-SIRT1-SM22? loop evokes a self-limited inflammatory response in vascular smooth muscle cells. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29952352&form=6&db=m Serum containing Buyang Huanwu decoction prevents age-associated migration and invasion of human vascular smooth muscle cells by up regulating SIRT1 expression. causal interaction,unassigned 3,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30618267&form=6&db=m Crosstalk between mitochondrial hyperacetylation and oxidative stress in vascular dysfunction and hypertension. causal interaction,unassigned 3,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32330091&form=6&db=m Sirt1 during childhood is associated with microvascular function later in life. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33631165&form=6&db=m Protective effect of SIRT6 on cholesterol crystal-induced endothelial dysfunction via regulating ACE2 expression. causal interaction,unassigned 3,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34216621&form=6&db=m Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34448640&form=6&db=m Adverse childhood events and cardiovascular diseases: the potential role of Sirt1. causal interaction,unassigned 3,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34518478&form=6&db=m Activation of SIRT1 by Resveratrol Alleviates Pressure Overload-Induced Cardiac Hypertrophy via Suppression of TGF-?1 Signaling. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Carotid Artery Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25273948&form=6&db=m Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Carotid Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25213338&form=6&db=m Silent information regulator 2 homolog 1 counters cerebral hypoperfusion injury by deacetylating endothelial nitric oxide synthase. ongoing research,therapeutic application,unassigned 2,3,0 2.3.1.286 Carotid Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25634315&form=6&db=m SIRT1 attenuates severe ischemic damage by preserving cerebral blood flow. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.3.1.286 Cartilage Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27253997&form=6&db=m Clock Gene Bmal1 Modulates Human Cartilage Gene Expression by Crosstalk With Sirt1. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29487807&form=6&db=m miR-211 promotes lens epithelial cells apoptosis by targeting silent mating-type information regulation 2 homolog 1 in age-related cataracts. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31287252&form=6&db=m Relationship between SIRT1 gene expression level and disease in age-related cataract cases causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.3.1.286 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32478572&form=6&db=m Role of Blueberry Anthocyanin Extract in the Expression of SIRT1 and NF-?B in Rat Lens Epithelial Cells in Experimentally Induced DM. ongoing research,unassigned 3,0 2.3.1.286 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25281273&form=6&db=m Role of SIRT1 in autoimmune demyelination and neurodegeneration. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Cerebellar Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31859031&form=6&db=m Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31854225&form=6&db=m XingNaoJing injection ameliorates cerebral ischaemia/reperfusion injury via SIRT1-mediated inflammatory response inhibition. causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.286 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33841157&form=6&db=m Neuroprotective Effect of Astragaloside IV on Cerebral Ischemia/Reperfusion Injury Rats Through Sirt1/Mapt Pathway. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0 2.3.1.286 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22185448&form=6&db=m Targeting cardiovascular disease with novel SIRT1 pathways. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Cervical Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31677030&form=6&db=m SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3 2.3.1.286 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30993888&form=6&db=m SIRT3 elicited an anti-Warburg effect through HIF1?/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34322899&form=6&db=m Histone Deacetylase SIRT1 promotes loss of primary cilia in Cholangiocarcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28553227&form=6&db=m SRT1720 Alleviates ANIT-Induced Cholestasis in a Mouse Model. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30229970&form=6&db=m Fine-tuning of SIRT1 expression is essential to protect the liver from cholestatic liver disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Cholestasis, Intrahepatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34402258&form=6&db=m Advances in the role of silence information regulator family in pathological pregnancy. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28600541&form=6&db=m Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27930969&form=6&db=m Rhapontin ameliorates colonic epithelial dysfunction in experimental colitis through SIRT1 signaling. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32497625&form=6&db=m Cilostazol protects against acetic acid-induced colitis in rats: Possible role for cAMP/SIRT1 pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33513830&form=6&db=m Intestinal SIRT1 Deficiency-Related Intestinal Inflammation and Dysbiosis Aggravate TNF?-Mediated Renal Dysfunction in Cirrhotic Ascitic Mice. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23473037&form=6&db=m Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26595549&form=6&db=m Assessing Colonic Exposure, Safety, and Clinical Activity of SRT2104, a Novel Oral SIRT1 Activator, in Patients with Mild to Moderate Ulcerative Colitis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31636473&form=6&db=m Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2 2.3.1.286 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33204668&form=6&db=m Effect of Selenium Supplementation on Expression of SIRT1 and PGC-1? Genes in Ulcerative Colitis Patients: a Double Blind Randomized Clinical Trial. ongoing research,unassigned 3,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19413317&form=6&db=m Inhibition of Human Sirtuins by in Situ Generation of an Acetylated Lysine-ADP-Ribose Conjugate. causal interaction,unassigned 3,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19700324&form=6&db=m Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine. causal interaction,unassigned 3,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22479251&form=6&db=m MicroRNA Regulation of SIRT1. causal interaction,unassigned 3,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24512730&form=6&db=m The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26577410&form=6&db=m Sirt3 binds to and deacetylates mitochondrial pyruvate carrier 1 to enhance its activity. causal interaction,unassigned 3,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29323702&form=6&db=m Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29713184&form=6&db=m Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,1 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31188638&form=6&db=m Sirtuin 3 silencing impairs mitochondrial biogenesis and metabolism in colon cancer cells. ongoing research,therapeutic application,unassigned 4,3,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33147367&form=6&db=m Cytotoxicity of metformin against HT29 colon cancer cells contributes to mitochondrial Sirt3 upregulation. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22190494&form=6&db=m The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23045412&form=6&db=m Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25785061&form=6&db=m The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26363315&form=6&db=m Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26763348&form=6&db=m Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27145368&form=6&db=m Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27470380&form=6&db=m Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29944017&form=6&db=m The pluripotency network in colorectal cancer pathogenesis and prognosis: an update. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30021354&form=6&db=m Sirt3-mediated mitochondrial fission regulates the colorectal cancer stress response by modulating the Akt/PTEN signalling pathway. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30319549&form=6&db=m SIRT1 in Secretory Organ Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30986062&form=6&db=m Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31981728&form=6&db=m Antioxidant enzymes change in different non-metastatic stages in tumoral and peritumoral tissues of colorectal cancer. causal interaction,unassigned 3,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32742376&form=6&db=m TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33046442&form=6&db=m SIRT1-Mediated Expression of CD24 and Epigenetic Suppression of Novel Tumor Suppressor miR-1185-1 Increases Colorectal Cancer Stemness. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33315089&form=6&db=m SIRT4 is the molecular switch mediating cellular proliferation in colorectal cancer through GLS mediated activation of AKT/GSK3?/CyclinD1 pathway. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33393034&form=6&db=m SIRT3-Mediated SOD2 and PGC-1? Contribute to Chemoresistance in Colorectal Cancer Cells. ongoing research,unassigned 3,0 2.3.1.286 Congenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23474063&form=6&db=m Folate and fetal programming: a play in epigenomics? causal interaction,unassigned 3,0 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27841908&form=6&db=m Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33381707&form=6&db=m The relationship between coronary artery disease and SIRT1 protein. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 2.3.1.286 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22185448&form=6&db=m Targeting cardiovascular disease with novel SIRT1 pathways. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31805818&form=6&db=m Shorter Leukocyte Telomere Lengths in Healthy Relatives of Patients with Coronary Heart Disease. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.286 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33864594&form=6&db=m Evaluation of sirtuin 1 (SIRT1) levels in autosomal dominant polycystic kidney disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 2.3.1.286 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23104101&form=6&db=m Seven sirtuins for seven deadly diseases of aging. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26594146&form=6&db=m Evidence for a neuroprotective microRNA pathway in amnestic mild cognitive impairment. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29855513&form=6&db=m SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30071285&form=6&db=m Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.3.1.286 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30361109&form=6&db=m SIRT1: The Value of Functional Outcome, Stroke-Related Dementia, Anxiety, and Depression in Patients with Acute Ischemic Stroke. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25281273&form=6&db=m Role of SIRT1 in autoimmune demyelination and neurodegeneration. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30953735&form=6&db=m Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34147476&form=6&db=m Tenovin-1 inhibited dengue virus replication through SIRT2. therapeutic application,unassigned 3,0 2.3.1.286 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31017270&form=6&db=m Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7. causal interaction,ongoing research,unassigned 3,3,0 2.3.1.286 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32679047&form=6&db=m Inhibiting Protein Kinase Activity of Pyruvate Kinase M2 by SIRT2 Deacetylase Attenuates Psoriasis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30168428&form=6&db=m The emerging role of the epigenetic enzyme Sirtuin-1 and high mobility group Box 1 in patients with diabetic foot ulceration. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30901315&form=6&db=m Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34214583&form=6&db=m Sirtuin 1 as the mechanism of action of agents used in the diabetes mellitus pharmacotherapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,3,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19107194&form=6&db=m Phosphorylation regulates SIRT1 function. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20044906&form=6&db=m SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22588935&form=6&db=m [Hepatic SIRT1 and UCP2 expressions in rats with type 2 diabetes mellitus and nonalcoholic fatty liver]. ongoing research,unassigned 3,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23239315&form=6&db=m Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24071688&form=6&db=m [Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver.] causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24952428&form=6&db=m In vivo RNA interference models of inducible and reversible Sirt1 knockdown in kidney cells. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25109279&form=6&db=m Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26105582&form=6&db=m Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26588494&form=6&db=m The Emerging Role of Sirtuin 1 in Cellular Metabolism, Diabetes Mellitus, Diabetic Kidney Disease and Hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27470548&form=6&db=m SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28329774&form=6&db=m [Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29371109&form=6&db=m Functional genetic variants within the SIRT2 gene promoter in type 2 diabetes mellitus. ongoing research,unassigned 3,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30320001&form=6&db=m The Association between SIRT1 Genetic Variation and Type 2 Diabetes Mellitus Is Influenced by Dietary Intake in Elderly Chinese. causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30901315&form=6&db=m Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30980188&form=6&db=m Rs12778366 single nucleotide polymorphism of Sirtuin 1 (SIRT1) and response to resveratrol supplementation in patients with type 2 diabetes mellitus. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32478572&form=6&db=m Role of Blueberry Anthocyanin Extract in the Expression of SIRT1 and NF-?B in Rat Lens Epithelial Cells in Experimentally Induced DM. ongoing research,unassigned 3,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33586458&form=6&db=m Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34214583&form=6&db=m Sirtuin 1 as the mechanism of action of agents used in the diabetes mellitus pharmacotherapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,3,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34439776&form=6&db=m Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23473037&form=6&db=m Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28377410&form=6&db=m Papers of note in Science Immunology2 (9). causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30228292&form=6&db=m SIRT1 activation attenuates ? cell hyperplasia, hyperglucagonaemia and hyperglycaemia in STZ-diabetic mice. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30736780&form=6&db=m The expression of sirtuins, superoxide dismutase, and lipid peroxidation status in peripheral blood from patients with diabetes and hypothyroidism. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34439776&form=6&db=m Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17908559&form=6&db=m SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. ongoing research,therapeutic application,unassigned 3,3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18005249&form=6&db=m Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18046409&form=6&db=m Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19107194&form=6&db=m Phosphorylation regulates SIRT1 function. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19273250&form=6&db=m Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19284563&form=6&db=m Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19581416&form=6&db=m TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20044906&form=6&db=m SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20061378&form=6&db=m SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20923823&form=6&db=m Hexosamines stimulate apoptosis by altering Sirt1 action and levelsin rodent pancreatic {beta}-cells. diagnostic usage,unassigned 3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20925017&form=6&db=m Differential Effects of Resveratrol and SRT1720 on Lifespan of Adult Caenorhabditis elegans. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21709297&form=6&db=m Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21879449&form=6&db=m The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22588935&form=6&db=m [Hepatic SIRT1 and UCP2 expressions in rats with type 2 diabetes mellitus and nonalcoholic fatty liver]. ongoing research,unassigned 3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22613205&form=6&db=m Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22762724&form=6&db=m Can targeting SIRT-1 to treat type 2 diabetes be a good strategy? A review. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23024708&form=6&db=m Sirtuin biology and relevance to diabetes treatment. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23133645&form=6&db=m The interactive effect of SIRT1 promoter region polymorphism on type 2 diabetes susceptibility in the North Indian population. ongoing research,unassigned 3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23239315&form=6&db=m Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23284689&form=6&db=m A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24071688&form=6&db=m [Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver.] causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25109279&form=6&db=m Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26105582&form=6&db=m Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26964730&form=6&db=m PDE5 Inhibition Ameliorates Visceral Adiposity Targeting the miR-22/SIRT1 Pathway: Evidence From the CECSID Trial. causal interaction,unassigned 3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27482292&form=6&db=m A Label-free Sirtuin 1 Assay based on Droplet-Electrospray Ionization Mass Spectrometry. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27592202&form=6&db=m Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding. causal interaction,unassigned 3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28973648&form=6&db=m The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29256638&form=6&db=m Mitochondria, the NLRP3 Inflammasome, and Sirtuins in Type 2 Diabetes: New Therapeutic Targets. causal interaction,unassigned 3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29371109&form=6&db=m Functional genetic variants within the SIRT2 gene promoter in type 2 diabetes mellitus. ongoing research,unassigned 3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30320001&form=6&db=m The Association between SIRT1 Genetic Variation and Type 2 Diabetes Mellitus Is Influenced by Dietary Intake in Elderly Chinese. causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30385301&form=6&db=m SirT3 regulates diabetogenic effects caused by arsenic: An implication for mitochondrial complex II modification. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30513672&form=6&db=m Expression Profile of Diabetes-Related Genes Associated with Leukocyte Sirtuin 1 Overexpression in Gestational Diabetes. causal interaction,unassigned 3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30603244&form=6&db=m Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30736780&form=6&db=m The expression of sirtuins, superoxide dismutase, and lipid peroxidation status in peripheral blood from patients with diabetes and hypothyroidism. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30901315&form=6&db=m Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30980188&form=6&db=m Rs12778366 single nucleotide polymorphism of Sirtuin 1 (SIRT1) and response to resveratrol supplementation in patients with type 2 diabetes mellitus. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32276962&form=6&db=m Role of Impaired Nutrient and Oxygen Deprivation Signaling and Deficient Autophagic Flux in Diabetic CKD Development: Implications for Understanding the Effects of Sodium-Glucose Cotransporter 2-Inhibitors. causal interaction,unassigned 3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32438712&form=6&db=m Haplotypes of the Mutated SIRT2 Promoter Contributing to Transcription Factor Binding and Type 2 Diabetes Susceptibility. diagnostic usage,unassigned 3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33191653&form=6&db=m Sirt3 regulates adipogenesis and adipokine secretion via its enzymatic activity. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34214583&form=6&db=m Sirtuin 1 as the mechanism of action of agents used in the diabetes mellitus pharmacotherapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34216621&form=6&db=m Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Diabetes, Gestational http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30513672&form=6&db=m Expression Profile of Diabetes-Related Genes Associated with Leukocyte Sirtuin 1 Overexpression in Gestational Diabetes. causal interaction,unassigned 3,0 2.3.1.286 Diabetes, Gestational http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34402258&form=6&db=m Advances in the role of silence information regulator family in pathological pregnancy. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20044906&form=6&db=m SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24341361&form=6&db=m Advanced glycation end-products impair Na?/K?-ATPase activity in diabetic cardiomyopathy: role of the adenosine monophosphate-activated protein kinase/sirtuin 1 pathway. causal interaction,unassigned 3,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28380414&form=6&db=m The role of SIRT1 in diabetic cardiomyopathy. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28714516&form=6&db=m (-)-Epigallocatechin-3-gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions. causal interaction,unassigned 3,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32770173&form=6&db=m Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33062139&form=6&db=m Bakuchiol Alleviates Hyperglycemia-Induced Diabetic Cardiomyopathy by Reducing Myocardial Oxidative Stress via Activating the SIRT1/Nrf2 Signaling Pathway. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33586458&form=6&db=m Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetic Foot http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30168428&form=6&db=m The emerging role of the epigenetic enzyme Sirtuin-1 and high mobility group Box 1 in patients with diabetic foot ulceration. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23361587&form=6&db=m Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,4 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23416120&form=6&db=m 3,5-Diiodo-l-thyronine ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats. therapeutic application,unassigned 3,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25346724&form=6&db=m The Role of SIRT1 in Diabetic Kidney Disease. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25386563&form=6&db=m Renal protective effect of sirtuin 1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26083654&form=6&db=m Sirtuin and metabolic kidney disease. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26588494&form=6&db=m The Emerging Role of Sirtuin 1 in Cellular Metabolism, Diabetes Mellitus, Diabetic Kidney Disease and Hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26872534&form=6&db=m Sirt1 is essential for resveratrol enhancement of hypoxia-induced autophagy in the type 2 diabetic nephropathy rat. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26931472&form=6&db=m Epigenetic regulation through SIRT1 in podocytes. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27470548&form=6&db=m SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28860538&form=6&db=m SIRT1 rs10823108 and FOXO1 rs17446614 responsible for genetic susceptibility to diabetic nephropathy. causal interaction,unassigned 3,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29104634&form=6&db=m Endogenous Nampt upregulation is associated with diabetic nephropathy inflammatory-fibrosis through the NF-?B p65 and Sirt1 pathway; NMN alleviates diabetic nephropathy inflammatory-fibrosis by inhibiting endogenous Nampt. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29477240&form=6&db=m Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32555442&form=6&db=m Sirt1 inhibits renal tubular cell epithelial-mesenchymal transition through YY1 deacetylation in diabetic nephropathy. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34128987&form=6&db=m Cissus quadrangularis extract attenuates diabetic nephropathy by altering SIRT1/DNMT1 axis. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34152844&form=6&db=m Correlation Between Polymorphisms of the SIRT1 Gene microRNA Target Sites and Diabetic Nephropathy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32459048&form=6&db=m Formononetin Ameliorates Diabetic Neuropathy by Increasing Expression of SIRT1 and NGF. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24570140&form=6&db=m miR-195 regulates SIRT1-mediated changes in diabetic retinopathy. causal interaction,unassigned 3,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26599598&form=6&db=m Molecular Mechanism of Transcriptional Regulation of Matrix Metalloproteinase-9 in Diabetic Retinopathy. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26692487&form=6&db=m Deacetylation of MnSOD by PARP-regulated SIRT3 protects retinal capillary endothelial cells from hyperglycemia-induced damage. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26889251&form=6&db=m Protective effects of SIRT1 in patients with proliferative diabetic retinopathy via the inhibition of IL-17 expression. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29091865&form=6&db=m The role of SIRT1 in diabetic retinopathy. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29311218&form=6&db=m Sirt1: A Guardian of the Development of Diabetic Retinopathy. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31702814&form=6&db=m Effects of microRNA?217 on high glucose?induced inflammation and apoptosis of human retinal pigment epithelial cells (ARPE?19) and its underlying mechanism. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32063865&form=6&db=m MicroRNA-29b-3p Promotes Human Retinal Microvascular Endothelial Cell Apoptosis via Blocking SIRT1 in Diabetic Retinopathy. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33536350&form=6&db=m Coumestrol mitigates retinal cell inflammation, apoptosis, and oxidative stress in a rat model of diabetic retinopathy via activation of SIRT1. ongoing research,unassigned 3,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33974755&form=6&db=m Arbutin inhibits inflammation and apoptosis by enhancing autophagy via SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.3.1.286 Dry Eye Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32566495&form=6&db=m PPAR?: the dominant regulator among PPARs in dry eye lacrimal gland and diabetic lacrimal gland. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 2.3.1.286 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23284689&form=6&db=m A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26246194&form=6&db=m Inhibition of miR-29 has a significant lipid-lowering benefit through suppression of lipogenic programs in liver. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28329774&form=6&db=m [Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 2.3.1.286 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30355082&form=6&db=m Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24013120&form=6&db=m The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30953735&form=6&db=m Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30953735&form=6&db=m Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33327875&form=6&db=m Sirtuin 2 in Endometrial Cancer: A Potential Regulator for Cell Proliferation, Apoptosis and RAS/ERK Pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34476599&form=6&db=m Sirtuin 2 promotes cell stemness and MEK/ERK signaling pathway while reduces chemosensitivity in endometrial cancer. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28754906&form=6&db=m KRAS Activation and over-expression of SIRT1/BCL6 Contributes to the Pathogenesis of Endometriosis and Progesterone Resistance. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.3.1.286 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29447380&form=6&db=m Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32046380&form=6&db=m Differential Expression of KRAS and SIRT1 in Ovarian Cancers with and Without Endometriosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2 2.3.1.286 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28634345&form=6&db=m Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.3.1.286 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30528733&form=6&db=m Constant light exposure aggravates POMC-mediated muscle wasting associated with hypothalamic alteration of circadian clock and SIRT1 in endotoxemia rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30009381&form=6&db=m Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.3.1.286 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31173166&form=6&db=m miR?128 is upregulated in epilepsy and promotes apoptosis through the SIRT1 cascade. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32461588&form=6&db=m Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Epiretinal Membrane http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26889251&form=6&db=m Protective effects of SIRT1 in patients with proliferative diabetic retinopathy via the inhibition of IL-17 expression. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25966629&form=6&db=m MicroRNA-200a is up-regulated in aged rats with erectile dysfunction and could attenuate endothelial function via SIRT1 inhibition. causal interaction,unassigned 3,0 2.3.1.286 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29282911&form=6&db=m [Aging-related change of erectile function and the expression of SIRT1]. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23871415&form=6&db=m Sirtuin-3 (SIRT3) expression is associated with overall survival in esophageal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 2.3.1.286 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25973238&form=6&db=m Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 2.3.1.286 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25005846&form=6&db=m SIRT3 is a novel prognostic biomarker for esophageal squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,3,0 2.3.1.286 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25922660&form=6&db=m SIRT1 expression is associated with lymphangiogenesis, lymphovascular invasion and prognosis in pN0 esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.286 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25973238&form=6&db=m Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 2.3.1.286 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29625788&form=6&db=m Clinicopathological and predictive significance of SIRT1 and peroxisome proliferator-activated receptor gamma in esophageal squamous cell carcinoma: The correlation with EGFR and Survivin. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.286 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32846774&form=6&db=m Expression of SIRT1 and survivin correlates with poor prognosis in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.3.1.286 Eye Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27856259&form=6&db=m Potential suppression of the high glucose and insulin-induced retinal neovascularization by Sirtuin 3 in the human retinal endothelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19724016&form=6&db=m Treatment with SRT1720, a SIRT1 Activator, Ameliorates Fatty Liver with Reduced Expression of Lipogenic Enzymes in MSG Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20071779&form=6&db=m Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. ongoing research,therapeutic application,unassigned 3,3,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20339025&form=6&db=m Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/- Mice: A Role of Lipid Mobilization and Inflammation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21856199&form=6&db=m SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23508103&form=6&db=m Activation of the aryl hydrocarbon receptor sensitizes mice to non-alcoholic steatohepatitis by deactivating the mitochondrial sirtuin deacetylase Sirt3. ongoing research,unassigned 3,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25361925&form=6&db=m Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26928655&form=6&db=m Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice. causal interaction,unassigned 3,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27910878&form=6&db=m Lipids: Celastrol protects against fatty liver through SIRT1. therapeutic application,unassigned 3,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29104641&form=6&db=m Targeting Sirt1 in a rat model of high-fat diet-induced non-alcoholic fatty liver disease: Comparison of Gegen Qinlian decoction and resveratrol. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30232347&form=6&db=m Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression. ongoing research,therapeutic application,unassigned 2,3,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30664220&form=6&db=m SIRT1 mediates the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPAR?/FoxO1 signaling pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32331890&form=6&db=m Sirtuin 3 improves fatty acid metabolism in response to high nonesterified fatty acids in calf hepatocytes by modulating gene expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32821334&form=6&db=m Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Fatty Liver, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29189974&form=6&db=m Association of SIRT1 gene polymorphism and its expression for the risk of alcoholic fatty liver disease in the Han population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 2.3.1.286 Fetal Growth Retardation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34402258&form=6&db=m Advances in the role of silence information regulator family in pathological pregnancy. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Flavivirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34147476&form=6&db=m Tenovin-1 inhibited dengue virus replication through SIRT2. therapeutic application,unassigned 3,0 2.3.1.286 Friedreich Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28724806&form=6&db=m Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Frontotemporal Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22416232&form=6&db=m Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29355701&form=6&db=m Helicobacter pylori infection increases sirt2 gene expression in gastric epithelial cells of gastritis patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26376991&form=6&db=m Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25286678&form=6&db=m [SIRT1 promote GTM cell DSBs repair and resist cellular senescence]. ongoing research,unassigned 3,0 2.3.1.286 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29249955&form=6&db=m Expression of Sirtuins in the Retinal Neurons of Mice, Rats, and Humans. causal interaction,unassigned 3,0 2.3.1.286 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22318540&form=6&db=m Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNF?)-induced apoptosis through SIRT1 inhibition. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26662303&form=6&db=m miR-22 inhibits the proliferation, motility, and invasion of human glioblastoma cells by directly targeting SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12963026&form=6&db=m Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16909107&form=6&db=m SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20470934&form=6&db=m MicroRNA-34a: a novel tumor suppressor in p53-mutant glioma cell line U251. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21655185&form=6&db=m MicroRNA and target protein patterns reveal physiopathological features of glioma subtypes. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22318540&form=6&db=m Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNF?)-induced apoptosis through SIRT1 inhibition. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22735931&form=6&db=m Prognostic significance of sirtuin 2 protein nuclear localization in glioma: an immunohistochemical study. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22867969&form=6&db=m SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24161395&form=6&db=m Sirt2 suppresses glioma cell growth through targeting NF-?B-miR-21 axis. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29308302&form=6&db=m Glioma-induced SIRT1-dependent activation of hMOF histone H4 lysine 16 acetyltransferase in microglia promotes a tumor supporting phenotype. causal interaction,unassigned 3,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29331678&form=6&db=m MicroRNA-320 Enhances Radiosensitivity of Glioma Through Down-Regulation of Sirtuin Type 1 by Directly Targeting Forkhead Box Protein M1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29872034&form=6&db=m Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH). ongoing research,therapeutic application,unassigned 4,3,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30506951&form=6&db=m Circular RNA hsa_circ_0076248 promotes oncogenesis of glioma by sponging miR-181a to modulate SIRT1 expression. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.3.1.286 Glomerulonephritis, IGA http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32482710&form=6&db=m IgA Nephropathy Benefits from Compound K Treatment by Inhibiting NF-?B/NLRP3 Inflammasome and Enhancing Autophagy and SIRT1. therapeutic application,unassigned 3,0 2.3.1.286 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31106362&form=6&db=m Sirt1 ameliorates monosodium urate crystal-induced inflammation by altering macrophage polarization via the PI3K/Akt/STAT6 pathway. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 2.3.1.286 Granulosa Cell Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33669567&form=6&db=m Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.3.1.286 Graves Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32485674&form=6&db=m Decreased SIRT1 expression in the peripheral blood of patients with Graves' disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 2.3.1.286 Hashimoto Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34439776&form=6&db=m Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32965071&form=6&db=m SIRT2 modulates VEGFD-associated lymphangiogenesis by deacetylating EPAS1 in human head and neck cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.3.1.286 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33727672&form=6&db=m MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22416140&form=6&db=m SIRT3 deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.3.1.286 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24124769&form=6&db=m Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence-Accelerated Mice. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24365660&form=6&db=m SIRT1 expression in the cochlea and auditory cortex of a mouse model of age-related hearing loss. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.3.1.286 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26928655&form=6&db=m Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice. causal interaction,unassigned 3,0 2.3.1.286 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29032664&form=6&db=m The Protective Effect of Egb 761 Against 3-Nitropropionic Acid-Induced Hearing Loss: The Role of Sirtuin 1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 2.3.1.286 Hearing Loss, Noise-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30616888&form=6&db=m The SIRT2 inhibitor AK-7 decreases cochlear cell apoptosis and attenuates noise-induced hearing loss. therapeutic application,unassigned 3,0 2.3.1.286 Hearing Loss, Sensorineural http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29032664&form=6&db=m The Protective Effect of Egb 761 Against 3-Nitropropionic Acid-Induced Hearing Loss: The Role of Sirtuin 1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 2.3.1.286 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26522013&form=6&db=m Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27357440&form=6&db=m Exogenous Hydrogen Sul?de Postconditioning Protects Isolated Rat Hearts From Ischemia/Reperfusion Injury Through Sirt1/PGC-1? Signaling Pathway. causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16207712&form=6&db=m Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17316625&form=6&db=m Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53. causal interaction,unassigned 3,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20089851&form=6&db=m Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21652783&form=6&db=m Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22691943&form=6&db=m Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice. causal interaction,unassigned 3,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25104317&form=6&db=m Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27393852&form=6&db=m SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27790619&form=6&db=m SIRT3 in Cardiac Physiology and Disease. causal interaction,unassigned 3,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28804553&form=6&db=m Sirt3 attenuates doxorubicin-induced cardiac hypertrophy and mitochondrial dysfunction via suppression of Bnip3. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31680473&form=6&db=m Protective mechanism of SIRT1 on Hcy-induced atrial fibrosis mediated by TRPC3. causal interaction,diagnostic usage,unassigned 3,1,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33523605&form=6&db=m Mangiferin prevents myocardial infarction-induced apoptosis and heart failure in mice by activating the Sirt1/FoxO3a pathway. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Heart Valve Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32294855&form=6&db=m [Association between single nucleotide polymorphism in promoter region of SIRT1 gene and senile degenerative heart valvular disease]. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Hepatitis A http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26388050&form=6&db=m The sirtuin inhibitor sirtinol inhibits hepatitis A virus (HAV) replication by inhibiting HAV internal ribosomal entry site activity. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22562294&form=6&db=m Hepatitis B virus X (HBX) protein upregulates ?-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24335313&form=6&db=m Sirtuin 1 regulates hepatitis B virus transcription and replication by targeting transcription factor AP-1. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30275764&form=6&db=m AGK2, A SIRT2 Inhibitor, Inhibits Hepatitis B Virus Replication In Vitro And In Vivo. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31636473&form=6&db=m Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2 2.3.1.286 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33063092&form=6&db=m Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16219030&form=6&db=m Neuronal protection by sirtuins in Alzheimer's disease. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18221243&form=6&db=m Modulation of sirtuins: new targets for antiageing. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20561979&form=6&db=m Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24252177&form=6&db=m Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24386389&form=6&db=m Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24436303&form=6&db=m A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24922350&form=6&db=m SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells. causal interaction,unassigned 3,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25223731&form=6&db=m An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25608039&form=6&db=m The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26815359&form=6&db=m SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice. causal interaction,unassigned 3,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27796760&form=6&db=m Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29654491&form=6&db=m SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.3.1.286 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32116550&form=6&db=m Reduction of Silent Information Regulator 1 Activates Interleukin-33/ST2 Signaling and Contributes to Neuropathic Pain Induced by Spared Nerve Injury in Rats. causal interaction,unassigned 3,0 2.3.1.286 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32126145&form=6&db=m Down-regulation of microRNA-34c-5p alleviates neuropathic pain via the SIRT1/STAT3 signaling pathway in rat models of chronic constriction injury of sciatic nerve. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33897435&form=6&db=m Sirt2 in the Spinal Cord Regulates Chronic Neuropathic Pain Through Nrf2-Mediated Oxidative Stress Pathway in Rats. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27470548&form=6&db=m SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28380414&form=6&db=m The role of SIRT1 in diabetic cardiomyopathy. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31184932&form=6&db=m Exogenous H2S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD+-SIRT3 pathway in cardiac tissues of db/db mice. diagnostic usage,unassigned 3,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32152092&form=6&db=m Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia. causal interaction,unassigned 3,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32459048&form=6&db=m Formononetin Ameliorates Diabetic Neuropathy by Increasing Expression of SIRT1 and NGF. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33003542&form=6&db=m The Relationship between Diabetes Mellitus Type II and Intervertebral Disc Degeneration in Diabetic Rodent Models: A Systematic and Comprehensive Review. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.286 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30394648&form=6&db=m Picroside II attenuates hyperhomocysteinemia-induced endothelial injury by reducing inflammation, oxidative stress and cell apoptosis. ongoing research,unassigned 3,0 2.3.1.286 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29417372&form=6&db=m Adipose tissue, but not skeletal muscle, sirtuin 1 expression is decreased in obesity and related to insulin sensitivity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18005249&form=6&db=m Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18482975&form=6&db=m SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21856199&form=6&db=m SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31184932&form=6&db=m Exogenous H2S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD+-SIRT3 pathway in cardiac tissues of db/db mice. diagnostic usage,unassigned 3,0 2.3.1.286 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20620997&form=6&db=m SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28744004&form=6&db=m Sirt1 negatively regulates Fc?RI-mediated mast cell activation through AMPK- and PTP1B-dependent processes. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25273948&form=6&db=m Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26284905&form=6&db=m The effect of SIRT1 gene polymorphisms on ambulatory blood pressure of hypertensive patients in the Kazakh population. causal interaction,unassigned 3,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26376991&form=6&db=m Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26562529&form=6&db=m Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26588494&form=6&db=m The Emerging Role of Sirtuin 1 in Cellular Metabolism, Diabetes Mellitus, Diabetic Kidney Disease and Hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27259994&form=6&db=m Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28329774&form=6&db=m [Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30483753&form=6&db=m MicroRNA-140-5p aggravates hypertension and oxidative stress of atherosclerosis via targeting Nrf2 and Sirt2. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30618267&form=6&db=m Crosstalk between mitochondrial hyperacetylation and oxidative stress in vascular dysfunction and hypertension. causal interaction,unassigned 3,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30677512&form=6&db=m Fibroblast growth factor 21 protects the heart from angiotensin II-induced cardiac hypertrophy and dysfunction via SIRT1. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31552474&form=6&db=m Sirt3 promotes sensitivity to sunitinib-induced cardiotoxicity via inhibition of GTSP1/JNK/autophagy pathway in vivo and in vitro. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32015327&form=6&db=m ?-Linolenic acid but not linolenic acid protects against hypertension: critical role of SIRT3 and autophagic flux. ongoing research,therapeutic application,unassigned 2,3,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34113795&form=6&db=m The association between left ventricular mass index and serum sirtuin 3 level in patients with hypertension. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 2.3.1.286 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24047466&form=6&db=m Sirt3 Deficiency Does not Augment Hypoxia-Induced Pulmonary Hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24047466&form=6&db=m Sirt3 Deficiency Does not Augment Hypoxia-Induced Pulmonary Hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26112889&form=6&db=m Protective effects of sirtuins in cardiovascular diseases: from bench to bedside. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25758293&form=6&db=m The effect of methimazole-induced postnatal hypothyroidism on the retinal maturation and on the Sirtuin 2 level. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30390331&form=6&db=m Targeting anti-aging protein sirtuin (Sirt) in the diagnosis of idiopathic pulmonary fibrosis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34202229&form=6&db=m SIRT3 Overexpression Ameliorates Asbestos-Induced Pulmonary Fibrosis, mt-DNA Damage, and Lung Fibrogenic Monocyte Recruitment. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25843933&form=6&db=m Calorie restriction attenuates cerebral ischemic injury via increasing SIRT1 synthesis in the rat. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27796760&form=6&db=m Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29654491&form=6&db=m SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.3.1.286 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32253651&form=6&db=m Sirt1-ROS-TRAF6 Signaling-Induced Pyroptosis Contributes to Early Injury in Ischemic Mice. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32500353&form=6&db=m Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1?/VEGF Signaling and Blood-Brain Barrier Integrity. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.3.1.286 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34227244&form=6&db=m QKI 6 ameliorates CIRI through promoting synthesis of triglyceride in neuron and inhibiting neuronal apoptosis associated with SIRT1-PPAR?-PGC-1? axis. ongoing research,unassigned 3,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20923823&form=6&db=m Hexosamines stimulate apoptosis by altering Sirt1 action and levelsin rodent pancreatic {beta}-cells. diagnostic usage,unassigned 3,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24335313&form=6&db=m Sirtuin 1 regulates hepatitis B virus transcription and replication by targeting transcription factor AP-1. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24376725&form=6&db=m MicroRNA-217 promotes angiogenesis of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and FOXO3A. causal interaction,unassigned 3,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24386389&form=6&db=m Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24858404&form=6&db=m Modulation of the AMPK/Sirt1 axis during neuronal infection by herpes simplex virus type 1. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25003320&form=6&db=m SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages. causal interaction,unassigned 3,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25661348&form=6&db=m {2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic acid methyl ester (MIAM) inhibited human hepatocellular carcinoma growth through upregulation of Sirtuin-3 (SIRT3). diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25890999&form=6&db=m Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology. causal interaction,unassigned 3,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26157176&form=6&db=m Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus-Induced Immune Responses. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26388050&form=6&db=m The sirtuin inhibitor sirtinol inhibits hepatitis A virus (HAV) replication by inhibiting HAV internal ribosomal entry site activity. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26763147&form=6&db=m Suppressive effects of sirtinol on human cytomegalovirus (hCMV) infection and hCMV-induced activation of molecular mechanisms of senescence and production of reactive oxygen species. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27019326&form=6&db=m Anaplasma phagocytophilum increases the levels of histone modifying enzymes to inhibit cell apoptosis and facilitate pathogen infection in the tick vector Ixodes scapularis. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27503897&form=6&db=m Human sirtuin 2 localization, transient interactions, and impact on the proteome point to its role in intracellular trafficking. causal interaction,unassigned 3,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28377410&form=6&db=m Papers of note in Science Immunology2 (9). causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28634345&form=6&db=m Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28951420&form=6&db=m Metabolic energy sensors as targets for designing host-directed therapies for tuberculosis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29355701&form=6&db=m Helicobacter pylori infection increases sirt2 gene expression in gastric epithelial cells of gastritis patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29694890&form=6&db=m Infection Reveals a Modification of SIRT2 Critical for Chromatin Association. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30275764&form=6&db=m AGK2, A SIRT2 Inhibitor, Inhibits Hepatitis B Virus Replication In Vitro And In Vivo. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31029687&form=6&db=m Role of Sirt1 in innate immune mechanisms against Mycobacterium tuberculosis via the inhibition of TAK1 activation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31545894&form=6&db=m Aberrant Decrease of the Endogenous SIRT3 and Increases of Acetylated Proteins in Scrapie Infected Cell Line SMB-S15 and in the Brains of Experimental Mice. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32106265&form=6&db=m Sirtuin 1 regulates mitochondrial function and immune homeostasis in respiratory syncytial virus infected dendritic cells. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32462533&form=6&db=m The dominant model analysis of Sirt3 genetic variants is associated with susceptibility to tuberculosis in a Chinese Han population. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33007281&form=6&db=m Sirtuin inhibits M. tuberculosis -induced apoptosis in macrophage through glycogen synthase kinase-3?. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34301894&form=6&db=m MYO1F regulates antifungal immunity by regulating acetylation of microtubules. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28278800&form=6&db=m 3 SIRT1-A POSSIBLE MARKER FOR REPRODUCTIVE AGING OF IN VIVO-DERIVED BOVINE OOCYTES? diagnostic usage,unassigned 3,0 2.3.1.286 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29447380&form=6&db=m Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17908559&form=6&db=m SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. ongoing research,therapeutic application,unassigned 3,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18046409&form=6&db=m Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19724016&form=6&db=m Treatment with SRT1720, a SIRT1 Activator, Ameliorates Fatty Liver with Reduced Expression of Lipogenic Enzymes in MSG Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19934007&form=6&db=m AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. causal interaction,unassigned 3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20528767&form=6&db=m Connecting the dots: molecular and epigenetic mechanisms in type 2 diabetes. causal interaction,unassigned 3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20823772&form=6&db=m Resveratrol: a relevant pharmacological approach for the treatment of metabolic syndrome? causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20848588&form=6&db=m Therapeutic potential of activators and inhibitors of sirtuins. therapeutic application,unassigned 3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21261652&form=6&db=m Resveratrol and life extension. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21483037&form=6&db=m Resveratrol-activated SIRT1 in liver and pancreatic ?-cells: a Janus head looking to the same direction of metabolic homeostasis. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21709297&form=6&db=m Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21732533&form=6&db=m High dose of dietary resveratrol enhances insulin sensitivity in healthy rats but does not lead to metabolite concentrations effective for SIRT1 expression. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21856199&form=6&db=m SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22309033&form=6&db=m Effects of resveratrol on the amelioration of insulin resistance in KKA(y) mice. causal interaction,unassigned 3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22476949&form=6&db=m Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity. ongoing research,unassigned 3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22564731&form=6&db=m SIRT1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in HepG2 cells via induction of oxygen-regulated protein 150. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23024708&form=6&db=m Sirtuin biology and relevance to diabetes treatment. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23445543&form=6&db=m Sirtuins as possible drug targets in type 2 diabetes. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23724165&form=6&db=m Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23734259&form=6&db=m Regulation of SIRT1 in vascular smooth muscle cells from streptozotocin-diabetic rats. causal interaction,unassigned 3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23880847&form=6&db=m (Healthy) ageing: focus on iodothyronines. causal interaction,unassigned 3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24142524&form=6&db=m Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24265619&form=6&db=m Adrenergic signaling and oxidative stress: a role for sirtuins? causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25349250&form=6&db=m Myeloid SIRT1 regulates macrophage infiltration and insulin sensitivity in mice fed a high-fat diet. ongoing research,unassigned 3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25614674&form=6&db=m [The role of SIRT1 in the pathogenesis of insulin resistance in skeletal muscle]. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25686565&form=6&db=m Resveratrol improves high-fat diet induced insulin resistance by rebalancing subsarcolemmal mitochondrial oxidation and antioxidantion. ongoing research,unassigned 3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25710929&form=6&db=m SIRT1 attenuates high glucose-induced insulin resistance via reducing mitochondrial dysfunction in skeletal muscle cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25948682&form=6&db=m SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat-Fed Mice. ongoing research,therapeutic application,unassigned 1,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25973386&form=6&db=m Adipocyte SIRT1 knockout promotes PPAR? activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26330758&form=6&db=m Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26538315&form=6&db=m Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism. ongoing research,unassigned 3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26562529&form=6&db=m Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26916242&form=6&db=m Diet-induced obesity and insulin resistance are associated with brown fat degeneration in SIRT1-deficient mice. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26923584&form=6&db=m SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27320865&form=6&db=m Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27468708&form=6&db=m Oral AGE restriction ameliorates insulin resistance in obese individuals with the metabolic syndrome: a randomised controlled trial. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27909699&form=6&db=m AAV-mediated Sirt1 overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistance. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28070709&form=6&db=m Influence of resveratrol on endoplasmic reticulum stress and expression of adipokines in adipose tissues/adipocytes induced by high-calorie diet or palmitic acid. causal interaction,unassigned 3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28118644&form=6&db=m The Gender Association of the SIRT1 rs7895833 Polymorphism with Pediatric Obesity: A 3-Year Panel Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28688179&form=6&db=m Resveratrol attenuates excessive ethanol exposure induced insulin resistance in rats via improving NAD(+) /NADH ratio. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,3 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28973648&form=6&db=m The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29032153&form=6&db=m Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29371109&form=6&db=m Functional genetic variants within the SIRT2 gene promoter in type 2 diabetes mellitus. ongoing research,unassigned 3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29417372&form=6&db=m Adipose tissue, but not skeletal muscle, sirtuin 1 expression is decreased in obesity and related to insulin sensitivity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29634925&form=6&db=m Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29898623&form=6&db=m Depletion of Sirt3 leads to the impairment of adipogenic differentiation and insulin resistance via interfering mitochondrial function of adipose-derived human mesenchymal stem cells. causal interaction,ongoing research,unassigned 3,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30054532&form=6&db=m Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30471862&form=6&db=m Effects of myeloid sirtuin 1 deficiency on hypothalamic neurogranin in mice fed a high-fat diet. ongoing research,unassigned 3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30603244&form=6&db=m Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30707625&form=6&db=m Fatty acid type-specific regulation of SIRT1 does not affect insulin sensitivity in human skeletal muscle. ongoing research,unassigned 3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31246318&form=6&db=m Protectin DX ameliorates palmitate-induced hepatic insulin resistance through AMPK/SIRT1-mediated modulation of fetuin-A and SeP expression. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31524229&form=6&db=m GLP?1 improves palmitate?induced insulin resistance in human skeletal muscle via SIRT1 activity. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31990656&form=6&db=m PGRN exerts inflammatory effects via SIRT1-NF-?B in adipose insulin resistance. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32152092&form=6&db=m Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia. causal interaction,unassigned 3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32438712&form=6&db=m Haplotypes of the Mutated SIRT2 Promoter Contributing to Transcription Factor Binding and Type 2 Diabetes Susceptibility. diagnostic usage,unassigned 3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33053742&form=6&db=m Supplementation with Red Wine Extract Increases Insulin Sensitivity and Peripheral Blood Mononuclear Sirt1 Expression in Nondiabetic Humans. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33901577&form=6&db=m Silymarin ameliorates the disordered glucose metabolism of mice with diet-induced obesity by activating the hepatic SIRT1 pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32763411&form=6&db=m High glucose-induced PRDX3 acetylation contributes to glucotoxicity in pancreatic ?-cells: Prevention by Teneligliptin. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31451225&form=6&db=m Biochemical insight into pseudouridine synthase 7 (PUS7) as a novel interactor of sirtuin, SIRT1. ongoing research,unassigned 3,0 2.3.1.286 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25646749&form=6&db=m SIRT1 plays a Protective role in Intervertebral Disc Degeneration in a Puncture-Induced Rodent model. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27289467&form=6&db=m The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31773668&form=6&db=m SIRT3 retards intervertebral disc degeneration by anti-oxidative stress by activating the SIRT3/FOXO3/SOD2 signaling pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23461657&form=6&db=m A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26059355&form=6&db=m Neuroprotective Effects of Ginkgolide B Against Ischemic Stroke: A Review of Current Literature. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27796760&form=6&db=m Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28656393&form=6&db=m Emerging Roles of Sirtuins in Ischemic Stroke. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29654491&form=6&db=m SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30361109&form=6&db=m SIRT1: The Value of Functional Outcome, Stroke-Related Dementia, Anxiety, and Depression in Patients with Acute Ischemic Stroke. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30544370&form=6&db=m Prognostic value of Sirtuin1 in acute ischemic stroke and its correlation with functional outcomes. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32500353&form=6&db=m Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1?/VEGF Signaling and Blood-Brain Barrier Integrity. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.3.1.286 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32276962&form=6&db=m Role of Impaired Nutrient and Oxygen Deprivation Signaling and Deficient Autophagic Flux in Diabetic CKD Development: Implications for Understanding the Effects of Sodium-Glucose Cotransporter 2-Inhibitors. causal interaction,unassigned 3,0 2.3.1.286 Kidney Calculi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30548662&form=6&db=m SIRT3 inhibited the formation of calcium oxalate-induced kidney stones through regulating NRF2/HO-1 signaling pathway. causal interaction,ongoing research,unassigned 3,3,0 2.3.1.286 Kidney Calculi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30714469&form=6&db=m Association of sirtuin 1 gene polymorphisms with nephrolithiasis in Eastern chinese population. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23361587&form=6&db=m Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,4 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24247822&form=6&db=m Role of sirtuins in kidney disease. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25386563&form=6&db=m Renal protective effect of sirtuin 1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26083654&form=6&db=m Sirtuin and metabolic kidney disease. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27980322&form=6&db=m Sirtuin1 (SIRT1) Regulates Tumor Necrosis Factor-alpha (TNF-?-Induced) Aquaporin-2 (AQP2) Expression in Renal Medullary Collecting Duct Cells Through Inhibiting the NF-?B Pathway. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28425936&form=6&db=m Genistein Ameliorates Ischemia/Reperfusion-Induced Renal Injury in a SIRT1-Dependent Manner. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29477240&form=6&db=m Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31087539&form=6&db=m Impaired SIRT1 activity leads to diminution in glomerular endowment without accelerating age-associated GFR decline. causal interaction,unassigned 3,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34152844&form=6&db=m Correlation Between Polymorphisms of the SIRT1 Gene microRNA Target Sites and Diabetic Nephropathy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Learning Disabilities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23474063&form=6&db=m Folate and fetal programming: a play in epigenomics? causal interaction,unassigned 3,0 2.3.1.286 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28241112&form=6&db=m Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives. therapeutic application,unassigned 3,0 2.3.1.286 Lentivirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27856259&form=6&db=m Potential suppression of the high glucose and insulin-induced retinal neovascularization by Sirtuin 3 in the human retinal endothelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.3.1.286 Lentivirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30452596&form=6&db=m SIRT1 Deletion Impairs Retinal Endothelial Cell Migration Through Downregulation of VEGF-A/VEGFR-2 and MMP14. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16154098&form=6&db=m FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. ongoing research,unassigned 3,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18181330&form=6&db=m Myristica fragrans Houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation. ongoing research,unassigned 3,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21720136&form=6&db=m [New strategy of adult T-cell leukemia treatment targeted for anti-tumor immunity and a longevity gene-encoded protein]. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24133372&form=6&db=m The emerging and diverse roles of sirtuins in cancer: a clinical perspective. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24504520&form=6&db=m A correlation analysis of miRNA?34a and its predicted target genes in leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26466808&form=6&db=m CD150(-) Side Population Defines Leukemia Stem Cells in a BALB/c Mouse Model of CML and Is Depleted by Genetic Loss of SIRT1. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26646449&form=6&db=m SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28272704&form=6&db=m A minicircuitry comprised of microRNA-9 and SIRT1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28329774&form=6&db=m [Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29774136&form=6&db=m The impact of Mir-9 regulation in normal and malignant hematopoiesis. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30210557&form=6&db=m Differential Expression of Circadian Genes in Leukemia and a Possible Role for Sirt1 in Restoring the Circadian Clock in Chronic Myeloid Leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30318050&form=6&db=m Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32487610&form=6&db=m Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-?B Pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34189942&form=6&db=m Deregulation of mitochondrial sirtuins and OGG1-2a acts as a prognostic and diagnostic biomarker in leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3 2.3.1.286 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23108383&form=6&db=m HDAC isoenzyme expression is deregulated in chronic lymphocytic leukemia B-cells and has a complex prognostic significance. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29713184&form=6&db=m Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,1 2.3.1.286 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21555002&form=6&db=m EVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1. diagnostic usage,unassigned 3,0 2.3.1.286 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26157347&form=6&db=m Sensitization of chemo-resistant human chronic myeloid leukemia stem-like cells to Hsp90 inhibitor by SIRT1 inhibition. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 2.3.1.286 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26646449&form=6&db=m SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30210557&form=6&db=m Differential Expression of Circadian Genes in Leukemia and a Possible Role for Sirt1 in Restoring the Circadian Clock in Chronic Myeloid Leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.3.1.286 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31407410&form=6&db=m Nicotinamide increases the sensitivity of chronic myeloid leukemia cells to doxorubicin via the inhibition of SIRT1. ongoing research,unassigned 3,0 2.3.1.286 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26646449&form=6&db=m SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25280219&form=6&db=m SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27291931&form=6&db=m SIRT2 is an unfavorable prognostic biomarker in patients with acute myeloid leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.3.1.286 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28272704&form=6&db=m A minicircuitry comprised of microRNA-9 and SIRT1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31261609&form=6&db=m The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.3.1.286 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32487610&form=6&db=m Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-?B Pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Listeriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28634345&form=6&db=m Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.3.1.286 Listeriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29694890&form=6&db=m Infection Reveals a Modification of SIRT2 Critical for Chromatin Association. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27888541&form=6&db=m TWEAK increases SIRT1 expression and promotes p53 deacetylation affecting human hepatic stellate cell senescence. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29933196&form=6&db=m Protective effects of selenium-glutathione-enriched probiotics on CCl4-induced liver fibrosis. causal interaction,unassigned 3,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32269528&form=6&db=m Noninvasive 40-Hz Light Flicker Rescues Circadian Behavior and Abnormal Lipid Metabolism Induced by Acute Ethanol Exposure via Improving SIRT1 and the Circadian Clock in the Liver-Brain Axis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33029279&form=6&db=m Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33522656&form=6&db=m Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress-induced premature senescence. ongoing research,unassigned 3,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17498258&form=6&db=m The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17785073&form=6&db=m [Effects of calorie restriction on SIRT1 expression in liver of nonalcoholic fatty liver disease: experiment with rats] causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23827175&form=6&db=m Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes. causal interaction,unassigned 3,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23993977&form=6&db=m Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24071688&form=6&db=m [Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver.] causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24451382&form=6&db=m A Redox-resistant Sirtuin-1 Mutant Protects against Hepatic Metabolic and Oxidant Stress. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25361925&form=6&db=m Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27831566&form=6&db=m Cysteine cathepsins control hepatic NF-?B-dependent inflammation via sirtuin-1 regulation. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28899784&form=6&db=m MiR-181b regulates steatosis in nonalcoholic fatty liver disease via targeting SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29104641&form=6&db=m Targeting Sirt1 in a rat model of high-fat diet-induced non-alcoholic fatty liver disease: Comparison of Gegen Qinlian decoction and resveratrol. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29189974&form=6&db=m Association of SIRT1 gene polymorphism and its expression for the risk of alcoholic fatty liver disease in the Han population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30229970&form=6&db=m Fine-tuning of SIRT1 expression is essential to protect the liver from cholestatic liver disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30525304&form=6&db=m SIRT3 Deficiency Promotes High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Correlation with Impaired Intestinal Permeability through Gut Microbial Dysbiosis. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30664220&form=6&db=m SIRT1 mediates the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPAR?/FoxO1 signaling pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31610175&form=6&db=m Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32331890&form=6&db=m Sirtuin 3 improves fatty acid metabolism in response to high nonesterified fatty acids in calf hepatocytes by modulating gene expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34183378&form=6&db=m Silybin Restored CYP3A Expression through the Sirtuin 2/Nuclear Factor ?-B Pathway in Mouse Nonalcoholic Fatty Liver Disease. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31474877&form=6&db=m Hepatic SIRT3 Upregulation in Response to Chronic Alcohol Consumption Contributes to Alcoholic Liver Disease in Mice. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.3.1.286 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31610175&form=6&db=m Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32236798&form=6&db=m Dietary schizophyllan reduces mitochondrial damage by activating SIRT3 in mice. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32269528&form=6&db=m Noninvasive 40-Hz Light Flicker Rescues Circadian Behavior and Abnormal Lipid Metabolism Induced by Acute Ethanol Exposure via Improving SIRT1 and the Circadian Clock in the Liver-Brain Axis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33162823&form=6&db=m Emerging Roles of SIRT1 in Alcoholic Liver Disease. diagnostic usage,unassigned 3,0 2.3.1.286 Liver Failure, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31129140&form=6&db=m Protective role of AGK2 on thioacetamide-induced acute liver failure in mice. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23564453&form=6&db=m Transcriptional and translational regulation of C/EBP?-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1? proteins at the early and late stages of liver cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23728341&form=6&db=m MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23814050&form=6&db=m Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells. ongoing research,unassigned 3,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30008835&form=6&db=m MicroRNA-29c restores cisplatin sensitivity in liver cancer through direct inhibition of sirtuin 1 expression. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32306906&form=6&db=m Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.3.1.286 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22178470&form=6&db=m SIRT1 as a therapeutic target in inflammaging of the pulmonary disease. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26212199&form=6&db=m BET Inhibition Upregulates SIRT1 and Alleviates Inflammatory Responses. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22646800&form=6&db=m Identification of Multiple Anti-inflammatory Pathways Triggered by Resveratrol Leading to Amelioration of Staphylococcal Enterotoxin B-Induced Lung Inflammation. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26935021&form=6&db=m SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28609013&form=6&db=m Polydatin alleviated radiation-induced lung injury through activation of Sirt3 and inhibition of epithelial-mesenchymal transition. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30868609&form=6&db=m Tanshinone IIA protects against lipopolysaccharide-induced lung injury through targeting Sirt1. therapeutic application,unassigned 3,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30918470&form=6&db=m Ginsenoside Rg1 Regulates SIRT1 to Ameliorate Sepsis-Induced Lung Inflammation and Injury via Inhibiting Endoplasmic Reticulum Stress and Inflammation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33063092&form=6&db=m Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33577060&form=6&db=m Effect of miR-132 on lung injury in sepsis rats via regulating Sirt1 expression. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17624472&form=6&db=m Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22986747&form=6&db=m SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23028940&form=6&db=m SIRT1 regulates endothelial Notch signaling in lung cancer. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23275008&form=6&db=m ?-Cryptoxanthin Restores Nicotine-Reduced Lung SIRT1 to Normal Levels and Inhibits Nicotine-Promoted Lung Tumorigenesis and Emphysema in A/J Mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23972545&form=6&db=m Cytokines from the tumor microenvironment modulate sirtinol cytotoxicity in A549 lung carcinoma cells. therapeutic application,unassigned 3,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24042441&form=6&db=m SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non-small cell lung cancer cells through deacetylation of NMNAT2. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24379401&form=6&db=m A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer. therapeutic application,unassigned 3,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25143434&form=6&db=m SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25184156&form=6&db=m The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/?-catenin-Foxo3a axis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26317794&form=6&db=m Enhanced nucleotide excision repair capacity in lung cancer cells by preconditioning with DNA-damaging agents. causal interaction,unassigned 3,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27528025&form=6&db=m Celecoxib and sulindac inhibit TGF-?1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28443025&form=6&db=m Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29435152&form=6&db=m miR-30a suppresses lung cancer progression by targeting SIRT1. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29713184&form=6&db=m Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,1 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29957526&form=6&db=m X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30016782&form=6&db=m Regulation of Apoptosis and Radiation Sensitization in Lung Cancer Cells via the Sirt1/NF-?B/Smac Pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30319549&form=6&db=m SIRT1 in Secretory Organ Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30710424&form=6&db=m Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells. diagnostic usage,therapeutic application,unassigned 3,1,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31656671&form=6&db=m Immunohistochemistry and clinical value of sirtuin 2 in non-metastasized non-small cell lung cancer. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31894331&form=6&db=m Sirtuin 3 induces apoptosis and necroptosis by regulating mutant p53 expression in small?cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32087970&form=6&db=m An RNA-binding-protein, NONO governs energy metabolism by regulating NAMPT in lung cancer. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32377734&form=6&db=m Effect of SIRT1 activators and inhibitors on CD44+/CD133+?enriched non?small cell lung cancer cells. therapeutic application,unassigned 3,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33777209&form=6&db=m MicroRNA-217 inhibits the proliferation and invasion, and promotes apoptosis of non-small cell lung cancer cells by targeting sirtuin 1. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34119539&form=6&db=m Silent information regulator 1 suppresses epithelial-to-mesenchymal transition in lung cancer cells via its regulation of mitochondria status. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34232204&form=6&db=m SIRT3 acts as a novel biomarker for the diagnosis of lung cancer: A retrospective study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24570024&form=6&db=m SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosus. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Lupus Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25386563&form=6&db=m Renal protective effect of sirtuin 1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Lupus Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29440621&form=6&db=m Urinary levels of sirtuin-1 associated with disease activity in lupus nephritis. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23768087&form=6&db=m MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26763348&form=6&db=m Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28166441&form=6&db=m Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31762241&form=6&db=m [Expression Level of SIRT2 in Cervical Cancer Tissue and Its Clinical Significance]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32846774&form=6&db=m Expression of SIRT1 and survivin correlates with poor prognosis in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33566315&form=6&db=m Sirtuin2 correlates with lymph node metastasis, increased FIGO stage, worse overall survival, and reduced chemosensitivity to cisplatin and paclitaxel in endometrial cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.3.1.286 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24133372&form=6&db=m The emerging and diverse roles of sirtuins in cancer: a clinical perspective. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27779675&form=6&db=m Resveratrol alleviates sepsis?induced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNF?? and myocardial apoptosis via activation of Sirt1. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.3.1.286 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28329774&form=6&db=m [Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 2.3.1.286 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28393364&form=6&db=m SIRT1 and AMPK pathways are essential for the proliferation and survival of primary effusion lymphoma cells. causal interaction,diagnostic usage,unassigned 3,1,0 2.3.1.286 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29521213&form=6&db=m Advances in spirocyclic hybrids: chemistry and medicinal actions. therapeutic application,unassigned 3,0 2.3.1.286 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30377410&form=6&db=m SIRT1 rs3758391 polymorphism and risk of diffuse large B cell lymphoma in a Chinese population. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26594596&form=6&db=m Melatonin Counteracts at a Transcriptional Level the Inflammatory and Apoptotic Response Secondary to Ischemic Brain Injury Induced by Middle Cerebral Artery Blockade in Aging Rats. diagnostic usage,unassigned 3,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27779675&form=6&db=m Resveratrol alleviates sepsis?induced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNF?? and myocardial apoptosis via activation of Sirt1. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30377410&form=6&db=m SIRT1 rs3758391 polymorphism and risk of diffuse large B cell lymphoma in a Chinese population. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655755&form=6&db=m Puerarin in inducing apoptosis of bladder cancer cells through inhibiting SIRT1/p53 pathway. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31973227&form=6&db=m Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32570218&form=6&db=m Sirt1 gene confers Adriamycin resistance in DLBCL via activating the PCG-1? mitochondrial metabolic pathway. causal interaction,unassigned 3,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33273545&form=6&db=m SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30377410&form=6&db=m SIRT1 rs3758391 polymorphism and risk of diffuse large B cell lymphoma in a Chinese population. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.286 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32570218&form=6&db=m Sirt1 gene confers Adriamycin resistance in DLBCL via activating the PCG-1? mitochondrial metabolic pathway. causal interaction,unassigned 3,0 2.3.1.286 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33273545&form=6&db=m SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Lymphoma, Primary Effusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28393364&form=6&db=m SIRT1 and AMPK pathways are essential for the proliferation and survival of primary effusion lymphoma cells. causal interaction,diagnostic usage,unassigned 3,1,0 2.3.1.286 Machado-Joseph Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27165717&form=6&db=m Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.3.1.286 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17827348&form=6&db=m Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity. causal interaction,unassigned 3,0 2.3.1.286 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28241112&form=6&db=m Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives. therapeutic application,unassigned 3,0 2.3.1.286 Malaria, Cerebral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18221799&form=6&db=m Biochemical characterization of Plasmodium falciparum Sir2, a NAD(+)-dependent deacetylase. causal interaction,unassigned 3,0 2.3.1.286 Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30184230&form=6&db=m Better Nutritional Status Is Positively Associated with mRNA Expression of SIRT1 in Community-Dwelling Older Adults in the Toledo Study for Healthy Aging. diagnostic usage,unassigned 3,0 2.3.1.286 Marfan Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26376991&form=6&db=m Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Massive Hepatic Necrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27711079&form=6&db=m Inactivation of Sirt1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-?B. ongoing research,unassigned 3,0 2.3.1.286 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25348795&form=6&db=m MiR-34a deficiency accelerates medulloblastoma formation in vivo. ongoing research,unassigned 3,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17566917&form=6&db=m Activation of the SIRT1 pathway and modulation of the cell cycle were involved in silymarin's protection against UV-induced A375-S2 cell apoptosis. ongoing research,unassigned 3,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24742694&form=6&db=m SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28166441&form=6&db=m Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28810544&form=6&db=m MicroRNA-9 inhibits the proliferation and migration of malignant melanoma cells via targeting sirituin 1. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31049320&form=6&db=m Tumour Expression of Histone Deacetylases in Uveal Melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31261609&form=6&db=m The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32124989&form=6&db=m Mitochondrial Sirtuins in Skin and Skin Cancers. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.286 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26818519&form=6&db=m Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31608237&form=6&db=m Sirtuin Family Members Selectively Regulate Autophagy in Osteosarcoma and Mesothelioma Cells in Response to Cellular Stress. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34277422&form=6&db=m CDKN2A Determines Mesothelioma Cell Fate to EZH2 Inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18482975&form=6&db=m SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18991791&form=6&db=m A review of Sirt1 and Sirt1 modulators in cardiovascular and metabolic diseases. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19356714&form=6&db=m Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19749157&form=6&db=m Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19883617&form=6&db=m FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20020036&form=6&db=m Hypothalamic Sirt1 regulates food intake in a rodent model system. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20689156&form=6&db=m Controlling SIRT1 expression by microRNAs in health and metabolic disease. causal interaction,unassigned 3,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20925017&form=6&db=m Differential Effects of Resveratrol and SRT1720 on Lifespan of Adult Caenorhabditis elegans. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21459330&form=6&db=m PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22479251&form=6&db=m MicroRNA Regulation of SIRT1. causal interaction,unassigned 3,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22849721&form=6&db=m Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22986685&form=6&db=m Indole-3-carbinol directly targets SIRT1 to inhibit adipocyte differentiation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23776383&form=6&db=m Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23832939&form=6&db=m Mass spectrometric studies on the in vitro generated metabolites of SIRT1 activating drugs for doping control purposes. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23880847&form=6&db=m (Healthy) ageing: focus on iodothyronines. causal interaction,unassigned 3,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28580187&form=6&db=m Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases. causal interaction,unassigned 3,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29147649&form=6&db=m Knockdown of causal interaction,unassigned 3,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29499851&form=6&db=m Effect of nutrient deprivation on the expression and the epigenetic signature of sirtuin genes. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30355082&form=6&db=m Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30603244&form=6&db=m Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31636473&form=6&db=m Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31973227&form=6&db=m Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32781070&form=6&db=m Sirtuins as endogenous regulators of lung fibrosis: A current perspective. causal interaction,unassigned 3,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19107194&form=6&db=m Phosphorylation regulates SIRT1 function. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20823772&form=6&db=m Resveratrol: a relevant pharmacological approach for the treatment of metabolic syndrome? causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21856199&form=6&db=m SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22017865&form=6&db=m Mitochondrial SIRT3: a new potential therapeutic target for metabolic syndrome. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22114326&form=6&db=m SIRT3 Regulates Mitochondrial Protein Acetylation and Intermediary Metabolism. causal interaction,unassigned 3,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22475539&form=6&db=m A patent review of sirtuin activators: an update. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22915706&form=6&db=m Sirtuins as regulators of mammalian aging. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23024708&form=6&db=m Sirtuin biology and relevance to diabetes treatment. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24297700&form=6&db=m The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24451382&form=6&db=m A Redox-resistant Sirtuin-1 Mutant Protects against Hepatic Metabolic and Oxidant Stress. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24625878&form=6&db=m Effects of natural mineral-rich water consumption on the expression of sirtuin 1 and angiogenic factors in the erectile tissue of rats with fructose-induced metabolic syndrome. ongoing research,unassigned 3,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26330758&form=6&db=m Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26567565&form=6&db=m Molecular Mechanisms of Latent Inflammation in Metabolic Syndrome. Possible Role of Sirtuins and Peroxisome Proliferator-Activated Receptor Type ?. causal interaction,unassigned 3,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26813102&form=6&db=m SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28329774&form=6&db=m [Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30355082&form=6&db=m Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Mitochondrial Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33102485&form=6&db=m Fra-1 Inhibits Cell Growth and the Warburg Effect in Cervical Cancer Cells via STAT1 Regulation of the p53 Signaling Pathway. ongoing research,unassigned 3,0 2.3.1.286 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21117229&form=6&db=m Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23945758&form=6&db=m Growth Inhibition and Apoptosis-Inducing Effects of Cudraflavone B in Human Oral Cancer Cells via MAPK, NF-?B, and SIRT1 Signaling Pathway. ongoing research,unassigned 3,0 2.3.1.286 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25329972&form=6&db=m Differential prooxidative effects of the green tea polyphenol, (-)-epigallocatechin-3-gallate, in normal and oral cancer cells are related to differences in sirtuin 3 signaling. ongoing research,unassigned 3,0 2.3.1.286 Movement Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29081897&form=6&db=m Mitochondrial Respiration in Intact Peripheral Blood Mononuclear Cells and Sirtuin 3 Activity in Patients with Movement Disorders. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22158107&form=6&db=m Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1. ongoing research,unassigned 3,0 2.3.1.286 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26679105&form=6&db=m Evidence for possible role of melatonin in reducing oxidative stress in multiple sclerosis through its effect on SIRT1 and antioxidant enzymes. ongoing research,unassigned 3,0 2.3.1.286 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34202956&form=6&db=m Association of miRNA and mRNA Levels of the Clinical Onset of Multiple Sclerosis Patients. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31340681&form=6&db=m Sirtuin 3 deficiency accelerates Angiotensin II-induced skeletal muscle atrophy. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32605216&form=6&db=m NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33481678&form=6&db=m Role of SIRT2 in regulating the dexamethasone-activated autophagy pathway in skeletal muscle atrophy. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30485429&form=6&db=m The novel relationship between Sirt3 and autophagy in myocardial ischemia-reperfusion. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33481678&form=6&db=m Role of SIRT2 in regulating the dexamethasone-activated autophagy pathway in skeletal muscle atrophy. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20041717&form=6&db=m Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues. therapeutic application,unassigned 3,0 2.3.1.286 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21652783&form=6&db=m Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27073590&form=6&db=m SIRT1: A Novel Target for the Treatment of Muscular Dystrophies. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30510631&form=6&db=m Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice. therapeutic application,unassigned 3,0 2.3.1.286 Muscular Dystrophy, Oculopharyngeal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20041717&form=6&db=m Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues. therapeutic application,unassigned 3,0 2.3.1.286 Mycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28634345&form=6&db=m Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.3.1.286 Mycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34301894&form=6&db=m MYO1F regulates antifungal immunity by regulating acetylation of microtubules. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30171011&form=6&db=m A SIRT1 Agonist May Be Beneficial in Myelodysplastic Syndrome. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22935421&form=6&db=m Genetic analysis of the SIRT1 gene promoter in myocardial infarction. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24039710&form=6&db=m Myocardial Injection of Apelin-Overexpressing Bone Marrow Cells Improves Cardiac Repair via Upregulation of Sirt3 after Myocardial Infarction. diagnostic usage,therapeutic application,unassigned 3,3,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27357440&form=6&db=m Exogenous Hydrogen Sul?de Postconditioning Protects Isolated Rat Hearts From Ischemia/Reperfusion Injury Through Sirt1/PGC-1? Signaling Pathway. causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27393852&form=6&db=m SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28901505&form=6&db=m SIRT1 confers protection against ischemia/reperfusion injury in cardiomyocytes via regulation of uncoupling protein 2 expression. causal interaction,unassigned 3,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30485429&form=6&db=m The novel relationship between Sirt3 and autophagy in myocardial ischemia-reperfusion. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31143479&form=6&db=m Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33155221&form=6&db=m Using ultrasound three-dimensional speckle tracking technology to explore the role of SIRT1 in ventricular remodeling after myocardial infarction. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,3 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33854356&form=6&db=m SIRT1 is Required for Exercise-Induced Beneficial Effects on Myocardial Ischemia/Reperfusion Injury. diagnostic usage,unassigned 3,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34146302&form=6&db=m miR-124-3p targeted SIRT1 to regulate cell apoptosis, inflammatory response, and oxidative stress in acute myocardial infarction in rats via modulation of the FGF21/CREB/PGC1? pathway. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 nadh:ubiquinone reductase (h+-translocating) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24895128&form=6&db=m Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28685526&form=6&db=m Glycyrrhetinic acid suppressed hmgb1 release by up-regulation of Sirt6 in nasal inflammation. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.286 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29767533&form=6&db=m Sirtuin-1 Controls Poly (I:C)-Dependent Matrix Metalloproteinase 9 Activation in Primary Human Nasal Epithelial Cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.3.1.286 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33036508&form=6&db=m [Research of SIRT1 on promoting the proliferation, migration and lipid metabolism of nasopharyngeal carcinoma]. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22249256&form=6&db=m SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23768087&form=6&db=m MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25281719&form=6&db=m Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25411356&form=6&db=m SRT1720 induces lysosomal-dependent cell death of breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26499759&form=6&db=m MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26763348&form=6&db=m Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27145368&form=6&db=m Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27345396&form=6&db=m O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway. causal interaction,unassigned 3,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28166441&form=6&db=m Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28781618&form=6&db=m MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28888043&form=6&db=m SIRT1 deacetylates KLF4 to activate Claudin-5 transcription in ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30237737&form=6&db=m Associations of sirtuins with clinicopathological parameters and prognosis in non-small cell lung cancer. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30373873&form=6&db=m Morphoproteomics and Biomedical Analytics Identify the c-Myc, EZH2, Sirt1 and CXCR4 Pathways as Potential Blocks to Differentiation Leading to Proliferation and Metastatic Potential in Sinonasal Undifferentiated Carcinoma (SNUC) and Provide Therapeutic Options: A Case Study. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30514680&form=6&db=m [SIRT1 participates in epithelial-mesenchymal transition of EC-9706 and Eca-109 cells in vitro by regulating Snail expression]. causal interaction,unassigned 3,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31040695&form=6&db=m SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-?B pathway. causal interaction,unassigned 3,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31116976&form=6&db=m Mitohormesis Primes Tumor Invasion and Metastasis. causal interaction,unassigned 3,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31551254&form=6&db=m Sirtuin6 (SIRT6) Promotes the EMT of Hepatocellular Carcinoma by Stimulating Autophagic Degradation of E-Cadherin. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31677030&form=6&db=m SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31692593&form=6&db=m MiR-29a function as tumor suppressor in cervical cancer by targeting SIRT1 and predict patient prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31723239&form=6&db=m Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31762241&form=6&db=m [Expression Level of SIRT2 in Cervical Cancer Tissue and Its Clinical Significance]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32154934&form=6&db=m SIRT1 regulates N6 -methyladenosine RNA modification in hepatocarcinogenesis by inducing RANBP2-dependent FTO SUMOylation. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32846774&form=6&db=m Expression of SIRT1 and survivin correlates with poor prognosis in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33164623&form=6&db=m The possible role of Sirtuins and microRNAs in hepatocellular carcinoma therapy. diagnostic usage,unassigned 3,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33326690&form=6&db=m MiR-770 promotes oral squamous cell carcinoma migration and invasion by regulating the Sirt7/Smad4 pathway. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33566315&form=6&db=m Sirtuin2 correlates with lymph node metastasis, increased FIGO stage, worse overall survival, and reduced chemosensitivity to cisplatin and paclitaxel in endometrial cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34119539&form=6&db=m Silent information regulator 1 suppresses epithelial-to-mesenchymal transition in lung cancer cells via its regulation of mitochondria status. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34147543&form=6&db=m Trending topics of SIRT1 in tumorigenicity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34232204&form=6&db=m SIRT3 acts as a novel biomarker for the diagnosis of lung cancer: A retrospective study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11672522&form=6&db=m Negative control of p53 by Sir2alpha promotes cell survival under stress. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12963026&form=6&db=m Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16288004&form=6&db=m Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16354677&form=6&db=m Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16386221&form=6&db=m [Chromosome arm 17p13.3: could hic1 be the one ?] causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16638127&form=6&db=m Differential expression of selected histone modifier genes in human solid cancers. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17316625&form=6&db=m Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17624472&form=6&db=m Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17806102&form=6&db=m Function of the SIRT1 protein deacetylase in cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18269226&form=6&db=m Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18838864&form=6&db=m JNK2-dependent regulation of SIRT1 protein stability. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18985648&form=6&db=m Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19075016&form=6&db=m Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19149601&form=6&db=m Cellular regulation of SIRT1. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19616958&form=6&db=m Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19649206&form=6&db=m Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19663498&form=6&db=m Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19944070&form=6&db=m Comparative deacetylase activity of wild type and mutants of SIRT1. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20129246&form=6&db=m SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20179424&form=6&db=m Sirt1 and cell migration. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20429629&form=6&db=m Deleted in Breast Cancer 1 (DBC1) is a dynamically regulated protein. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20470934&form=6&db=m MicroRNA-34a: a novel tumor suppressor in p53-mutant glioma cell line U251. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20813094&form=6&db=m Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20842312&form=6&db=m Sirtuin mechanism and inhibition: explored with N(?)-acetyl-lysine analogs. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20848560&form=6&db=m Neuroprotective properties of resveratrol in different neurodegenerative disorders. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20848588&form=6&db=m Therapeutic potential of activators and inhibitors of sirtuins. therapeutic application,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20941378&form=6&db=m Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21059157&form=6&db=m SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21062352&form=6&db=m Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21117229&form=6&db=m Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21189328&form=6&db=m Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21407215&form=6&db=m Multifunctional transcription factor TFII-I is an activator of BRCA1 function. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21459330&form=6&db=m PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21497774&form=6&db=m Complex roles of Sirtuin 1 in cancer and aging. diagnostic usage,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21527554&form=6&db=m Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21555002&form=6&db=m EVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1. diagnostic usage,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21606675&form=6&db=m Limited role of Sirt1 in cancer protection by dietary restriction. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21884983&form=6&db=m A biotin switch-based proteomics approach identifies 14-3-3? as a target of Sirt1 in the metabolic regulation of caspase-2. ongoing research,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21947960&form=6&db=m Proteomic analyses of Sirt1-mediated cisplatin resistance in OSCC cell line. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22086720&form=6&db=m Sirtuin 1 (SIRT1): the misunderstood HDAC. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22190494&form=6&db=m The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22249256&form=6&db=m SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22318540&form=6&db=m Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNF?)-induced apoptosis through SIRT1 inhibition. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22401932&form=6&db=m SIRT1 signaling as potential modulator of skeletal muscle diseases. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22416140&form=6&db=m SIRT3 deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22479251&form=6&db=m MicroRNA Regulation of SIRT1. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22554968&form=6&db=m Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22589271&form=6&db=m SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22609775&form=6&db=m Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22613205&form=6&db=m Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22674009&form=6&db=m Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22849721&form=6&db=m Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22986747&form=6&db=m SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22995302&form=6&db=m SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human THP-1 cells. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23045412&form=6&db=m Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23075766&form=6&db=m SIRT1 regulates CD40 expression induced by TNF-? via NF-?B pathway in endothelial cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23104101&form=6&db=m Seven sirtuins for seven deadly diseases of aging. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23272146&form=6&db=m Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23275008&form=6&db=m ?-Cryptoxanthin Restores Nicotine-Reduced Lung SIRT1 to Normal Levels and Inhibits Nicotine-Promoted Lung Tumorigenesis and Emphysema in A/J Mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23354305&form=6&db=m Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23452762&form=6&db=m Improved Expression of Sirt1 on Thymic Epithelial Cells of SAMP10 after Intra Bone Marrow-Bone Marrow Transplantation. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23542177&form=6&db=m SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23696314&form=6&db=m Sirtuins' modulation of autophagy. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23728341&form=6&db=m MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23777400&form=6&db=m Rhein lysinate decreases the generation of ?-amyloid in the brain tissues of Alzheimer's disease model mice by inhibiting inflammatory response and oxidative stress. diagnostic usage,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23868064&form=6&db=m Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress. ongoing research,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23970286&form=6&db=m Diet-induced obesity promotes murine gastric cancer growth through a nampt/sirt1/c-myc positive feedback loop. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24019980&form=6&db=m Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24020002&form=6&db=m SIRT1: Regulator of p53 Deacetylation. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24020005&form=6&db=m Deacetylation by SIRT1 Reprograms Inflammation and Cancer. causal interaction,ongoing research,unassigned 3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24042441&form=6&db=m SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non-small cell lung cancer cells through deacetylation of NMNAT2. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24088390&form=6&db=m High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24127549&form=6&db=m Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24133372&form=6&db=m The emerging and diverse roles of sirtuins in cancer: a clinical perspective. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24258275&form=6&db=m Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24386389&form=6&db=m Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24389023&form=6&db=m Structural basis for potent inhibition of SIRT2 deacetylase by a macrocyclic peptide inducing dynamic structural change. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24399205&form=6&db=m RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3' Nuclease-resistant Mini-hairpin Structure. ongoing research,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24423936&form=6&db=m Differential roles of Sirt1 in HIF-1? and HIF-2? mediated hypoxic responses. diagnostic usage,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24482345&form=6&db=m SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24512730&form=6&db=m The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24566137&form=6&db=m HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24713434&form=6&db=m Global transcriptome analysis of formalin-fixed prostate cancer specimens identifies biomarkers of disease recurrence. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24742694&form=6&db=m SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24774224&form=6&db=m Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24866770&form=6&db=m SIRT2 Interacts with ?-Catenin to Inhibit Wnt Signaling Output in Response to Radiation-Induced Stress. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25000096&form=6&db=m Structure-based drug design of small molecule SIRT1 modulators to treat cancer and metabolic disorders. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25085992&form=6&db=m Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25139823&form=6&db=m High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25143434&form=6&db=m SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25152236&form=6&db=m SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25184156&form=6&db=m The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/?-catenin-Foxo3a axis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25195573&form=6&db=m Deacetylation of phosphoglycerate mutase in its distinct central region by SIRT2 down-regulates its enzymatic activity. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25281719&form=6&db=m Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25311745&form=6&db=m TNF-? and LPS activate angiogenesis via VEGF and SIRT1 signalling in human dental pulp cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25332769&form=6&db=m SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25341037&form=6&db=m SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25380034&form=6&db=m Modulation of tumorigenesis by dietary intervention is not mediated by SIRT1 catalytic activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25386563&form=6&db=m Renal protective effect of sirtuin 1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25411356&form=6&db=m SRT1720 induces lysosomal-dependent cell death of breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25486244&form=6&db=m Anticancer agents targeted to sirtuins. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25557355&form=6&db=m Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes. ongoing research,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25660418&form=6&db=m Expression of SIRT2 and SIRT6 in retinoblastoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25737075&form=6&db=m Sirt1 regulates microtubule dynamics through negative regulation of Plk1 in mitosis. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25746104&form=6&db=m Multifaceted Modulation of SIRT1 in Cancer and Inflammation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25785061&form=6&db=m The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25791281&form=6&db=m Gene expression mapping of histone deacetylases and co-factors, and correlation with survival time and 1H-HRMAS metabolomic profile in human gliomas. causal interaction,diagnostic usage,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25794641&form=6&db=m Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25808624&form=6&db=m The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25890999&form=6&db=m Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25922660&form=6&db=m SIRT1 expression is associated with lymphangiogenesis, lymphovascular invasion and prognosis in pN0 esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25973238&form=6&db=m Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26121691&form=6&db=m SIRT3 Enhances Glycolysis and Proliferation in SIRT3-Expressing Gastric Cancer Cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26255724&form=6&db=m Sirtuin 1 (SIRT1) Deacetylase Activity and NAD?/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death. ongoing research,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26303530&form=6&db=m Group IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26339164&form=6&db=m AROS Is a Significant Biomarker for Tumor Aggressiveness in Non-cirrhotic Hepatocellular Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26363315&form=6&db=m Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26407304&form=6&db=m Insight into the Mechanism of Intramolecular Inhibition of the Catalytic Activity of Sirtuin 2 (SIRT2). causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26416354&form=6&db=m Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26481524&form=6&db=m Targeting aberrant cancer metabolism - The role of sirtuins. causal interaction,diagnostic usage,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26499759&form=6&db=m MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26523671&form=6&db=m MicroRNA-34a induces a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells with a wild-type p53 gene background. ongoing research,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26594596&form=6&db=m Melatonin Counteracts at a Transcriptional Level the Inflammatory and Apoptotic Response Secondary to Ischemic Brain Injury Induced by Middle Cerebral Artery Blockade in Aging Rats. diagnostic usage,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26631040&form=6&db=m The expression levels of the sirtuins in patients with BCC. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26646449&form=6&db=m SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26748890&form=6&db=m Structure-Based Development of an Affinity Probe for Sirtuin?2. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26805727&form=6&db=m Ligand-based virtual screening and inductive learning for identification of SIRT1 inhibitors in natural products. causal interaction,diagnostic usage,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26940009&form=6&db=m Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma. ongoing research,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26976689&form=6&db=m Effects of nasal CPAP on exhaled SIRT1 and tumor necrosis factor-? in patients with obstructive sleep apnea. ongoing research,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26986234&form=6&db=m Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26992208&form=6&db=m Distinct effects of SIRT1 in cancer and stromal cells on tumor promotion. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27114304&form=6&db=m Mitochondrial Sirt3 supports cell proliferation by regulating glutamine-dependent oxidation in renal cell carcinoma. ongoing research,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27145368&form=6&db=m Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27291931&form=6&db=m SIRT2 is an unfavorable prognostic biomarker in patients with acute myeloid leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27312708&form=6&db=m SIRT1-mediated transcriptional regulation of SOX2 is important for self-renewal of liver cancer stem cells. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27345396&form=6&db=m O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27470380&form=6&db=m Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27482292&form=6&db=m A Label-free Sirtuin 1 Assay based on Droplet-Electrospray Ionization Mass Spectrometry. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27494892&form=6&db=m Sirtuin1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27503897&form=6&db=m Human sirtuin 2 localization, transient interactions, and impact on the proteome point to its role in intracellular trafficking. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27503926&form=6&db=m SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27763638&form=6&db=m 1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27783945&form=6&db=m The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer. diagnostic usage,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27793057&form=6&db=m Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27875273&form=6&db=m SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27888541&form=6&db=m TWEAK increases SIRT1 expression and promotes p53 deacetylation affecting human hepatic stellate cell senescence. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27980322&form=6&db=m Sirtuin1 (SIRT1) Regulates Tumor Necrosis Factor-alpha (TNF-?-Induced) Aquaporin-2 (AQP2) Expression in Renal Medullary Collecting Duct Cells Through Inhibiting the NF-?B Pathway. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28025857&form=6&db=m Use of the Monte Carlo Method for OECD Principles-Guided QSAR Modeling of SIRT1 Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28109165&form=6&db=m Melatonin and sirtuins: A "not-so unexpected" relationship. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28166441&form=6&db=m Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28183536&form=6&db=m RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3' Nuclease-resistant Mini-hairpin Structure. ongoing research,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28240897&form=6&db=m Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28259910&form=6&db=m Reduced expression of SIRT2 in serous ovarian carcinoma promotes cell proliferation through disinhibition of CDK4 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28301150&form=6&db=m Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure-Activity Relationship Analysis. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28347248&form=6&db=m SIRT3 functions as a tumor suppressor in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28406396&form=6&db=m SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28419207&form=6&db=m CKII-SIRT1-SM22? loop evokes a self-limited inflammatory response in vascular smooth muscle cells. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28445726&form=6&db=m Sirtuin-1 Activation Controls Tumor Growth by Impeding Th17 Differentiation via STAT3 Deacetylation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28600541&form=6&db=m Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28653878&form=6&db=m Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28685526&form=6&db=m Glycyrrhetinic acid suppressed hmgb1 release by up-regulation of Sirt6 in nasal inflammation. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28704962&form=6&db=m SIRT3: Oncogene and Tumor Suppressor in Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28721811&form=6&db=m Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28797320&form=6&db=m Decreased Expression of MiR-138-5p by LncRNA H19 in Cervical Cancer Promotes Tumor Proliferation. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28804553&form=6&db=m Sirt3 attenuates doxorubicin-induced cardiac hypertrophy and mitochondrial dysfunction via suppression of Bnip3. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28903430&form=6&db=m Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius guentheri. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28943955&form=6&db=m p53 inhibits the upregulation of sirtuin 1 expression induced by c-Myc. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28992545&form=6&db=m Downregulation of SIRT2 Inhibits Invasion of Hepatocellular Carcinoma by Inhibiting Energy Metabolism. causal interaction,ongoing research,unassigned 3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29147649&form=6&db=m Knockdown of causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29152116&form=6&db=m microRNA-526b servers as a prognostic factor and exhibits tumor suppressive property by targeting Sirtuin 7 in hepatocellular carcinoma. diagnostic usage,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29250169&form=6&db=m Therapeutic strategies against cancer stem cells in human colorectal cancer. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29308302&form=6&db=m Glioma-induced SIRT1-dependent activation of hMOF histone H4 lysine 16 acetyltransferase in microglia promotes a tumor supporting phenotype. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29423902&form=6&db=m A Novel Substrate Radiotracer for Molecular Imaging of SIRT2 Expression and Activity with Positron Emission Tomography. diagnostic usage,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29476819&form=6&db=m Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29581731&form=6&db=m MicroRNA-34a regulates proliferation and apoptosis of gastric cancer cells by targeting silent information regulator 1. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29625788&form=6&db=m Clinicopathological and predictive significance of SIRT1 and peroxisome proliferator-activated receptor gamma in esophageal squamous cell carcinoma: The correlation with EGFR and Survivin. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29683756&form=6&db=m De novo expression of transfected sirtuin 3 enhances susceptibility of human MCF-7 breast cancer cells to hyperoxia treatment. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29713184&form=6&db=m Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29855479&form=6&db=m Fission Yeast Sirtuin Hst4 Functions in Preserving Genomic Integrity by Regulating Replisome Component Mcl1. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29957526&form=6&db=m X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30016782&form=6&db=m Regulation of Apoptosis and Radiation Sensitization in Lung Cancer Cells via the Sirt1/NF-?B/Smac Pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30021836&form=6&db=m Sirt1 protects from K-Ras-driven lung carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30050056&form=6&db=m TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30210557&form=6&db=m Differential Expression of Circadian Genes in Leukemia and a Possible Role for Sirt1 in Restoring the Circadian Clock in Chronic Myeloid Leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30319549&form=6&db=m SIRT1 in Secretory Organ Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30373873&form=6&db=m Morphoproteomics and Biomedical Analytics Identify the c-Myc, EZH2, Sirt1 and CXCR4 Pathways as Potential Blocks to Differentiation Leading to Proliferation and Metastatic Potential in Sinonasal Undifferentiated Carcinoma (SNUC) and Provide Therapeutic Options: A Case Study. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30409902&form=6&db=m Prostaglandin E2 down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity-breast cancer connection. causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30414146&form=6&db=m Characterization of FOXO Acetylation. ongoing research,therapeutic application,unassigned 2,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30487288&form=6&db=m Sirtuin 2-mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30510540&form=6&db=m Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30537988&form=6&db=m HDAC is indispensable for IFN-?-induced B7-H1 expression in gastric cancer. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30578970&form=6&db=m SIRT1 alleviates isoniazid-induced hepatocyte injury by reducing histone acetylation in the IL-6 promoter region. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30651760&form=6&db=m The HMGB1-RAGE/TLR-TNF-? signaling pathway may contribute to kidney injury induced by hypoxia. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30710424&form=6&db=m Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells. diagnostic usage,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30901096&form=6&db=m Sirtuin-1/Mitochondrial Ribosomal Protein S5 Axis Enhances the Metabolic Flexibility of Liver Cancer Stem Cells. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30918470&form=6&db=m Ginsenoside Rg1 Regulates SIRT1 to Ameliorate Sepsis-Induced Lung Inflammation and Injury via Inhibiting Endoplasmic Reticulum Stress and Inflammation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30933885&form=6&db=m The SIRT2/cMYC Pathway Inhibits Peroxidation-Related Apoptosis In Cholangiocarcinoma Through Metabolic Reprogramming. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30986062&form=6&db=m Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31028741&form=6&db=m Bouchardatine suppresses rectal cancer in mice by disrupting its metabolic pathways via activating the SIRT1-PGC-1?-UCP2 axis. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31040695&form=6&db=m SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-?B pathway. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31049320&form=6&db=m Tumour Expression of Histone Deacetylases in Uveal Melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31087297&form=6&db=m Assessment of SIRT2 Inhibitors in Mouse Models of Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31102152&form=6&db=m Increase of Hspa1a and Hspa1b genes in the resting B cells of Sirt1 knockout mice. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31173166&form=6&db=m miR?128 is upregulated in epilepsy and promotes apoptosis through the SIRT1 cascade. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31188638&form=6&db=m Sirtuin 3 silencing impairs mitochondrial biogenesis and metabolism in colon cancer cells. ongoing research,therapeutic application,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31201813&form=6&db=m SIRT1 downregulated FGB expression to inhibit RCC tumorigenesis by destabilizing STAT3. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31225445&form=6&db=m Novel role of the SIRT4-OPA1 axis in mitochondrial quality control. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31261609&form=6&db=m The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31276230&form=6&db=m Calycosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31306909&form=6&db=m Antiproliferative activity of (R)-4'-methylklavuzon on hepatocellular carcinoma cells and EpCAM+/CD133+ cancer stem cells via SIRT1 and Exportin-1 (CRM1) inhibition. ongoing research,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31367941&form=6&db=m Sirt1 inhibits gouty arthritis via activating PPAR?. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31373792&form=6&db=m A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31418154&form=6&db=m Upregulated tumor sirtuin 2 expression correlates with reduced TNM stage and better overall survival in surgical breast cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31526985&form=6&db=m Glycyrrhizin protects IGFBP-3 knockout mice from retinal damage. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31551254&form=6&db=m Sirtuin6 (SIRT6) Promotes the EMT of Hepatocellular Carcinoma by Stimulating Autophagic Degradation of E-Cadherin. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31574948&form=6&db=m Partially Hydrolyzed Guar Gum Attenuates d-Galactose-Induced Oxidative Stress and Restores Gut Microbiota in Rats. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31587155&form=6&db=m Ubiquitin-Specific Protease 22/Silent Information Regulator 1 Axis Plays a Pivotal Role in the Prognosis and 5-Fluorouracil Resistance in Hepatocellular Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31608237&form=6&db=m Sirtuin Family Members Selectively Regulate Autophagy in Osteosarcoma and Mesothelioma Cells in Response to Cellular Stress. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31636473&form=6&db=m Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31677030&form=6&db=m SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31692593&form=6&db=m MiR-29a function as tumor suppressor in cervical cancer by targeting SIRT1 and predict patient prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31723239&form=6&db=m Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31769563&form=6&db=m Nicotinamide-induced silencing of SIRT1 by miR-22-3p increases periodontal ligament stem cell proliferation and differentiation. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31817470&form=6&db=m The Roles of Sirtuin Family Proteins in Cancer Progression. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31839623&form=6&db=m Rikkunshito attenuates induction of epithelial-mesenchymal switch via activation of Sirtuin1 in ovarian cancer cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31970087&form=6&db=m Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet. ongoing research,therapeutic application,unassigned 1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31973227&form=6&db=m Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31981728&form=6&db=m Antioxidant enzymes change in different non-metastatic stages in tumoral and peritumoral tissues of colorectal cancer. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32154934&form=6&db=m SIRT1 regulates N6 -methyladenosine RNA modification in hepatocarcinogenesis by inducing RANBP2-dependent FTO SUMOylation. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32158696&form=6&db=m Integrative Analysis of Sirtuins and Their Prognostic Significance in Clear Cell Renal Cell Carcinoma. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32276460&form=6&db=m ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32292498&form=6&db=m miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss. causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32306906&form=6&db=m Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32321406&form=6&db=m In silico Design of Novel Sirtuin 1 Enzyme Activators for Treatment of Age-related Diseases and Life Span. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32340156&form=6&db=m Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32428596&form=6&db=m Combination of sirtuin 3 and hyperoxia diminishes tumorigenic properties of MDA-MB-231 cells. ongoing research,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32441762&form=6&db=m SIRT1-NOX4 signaling axis regulates cancer cachexia. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32487610&form=6&db=m Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-?B Pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32566495&form=6&db=m PPAR?: the dominant regulator among PPARs in dry eye lacrimal gland and diabetic lacrimal gland. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32681437&form=6&db=m Expression of SIRT1, SIRT3 and SIRT6 Genes for Predicting Survival in Triple-Negative and Hormone Receptor-Positive Subtypes of Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32742376&form=6&db=m TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32846774&form=6&db=m Expression of SIRT1 and survivin correlates with poor prognosis in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32900849&form=6&db=m Exploitation of DHODH and p53 activation as therapeutic targets - a case study in polypharmacology. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32965071&form=6&db=m SIRT2 modulates VEGFD-associated lymphangiogenesis by deacetylating EPAS1 in human head and neck cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32998713&form=6&db=m Profiles of autophagy-related genes in esophageal adenocarcinoma. causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33036508&form=6&db=m [Research of SIRT1 on promoting the proliferation, migration and lipid metabolism of nasopharyngeal carcinoma]. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33046442&form=6&db=m SIRT1-Mediated Expression of CD24 and Epigenetic Suppression of Novel Tumor Suppressor miR-1185-1 Increases Colorectal Cancer Stemness. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33059365&form=6&db=m From anti-aging drugs to cancer therapy: is there a potential for sirtuin activators in gliomas? causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33147367&form=6&db=m Cytotoxicity of metformin against HT29 colon cancer cells contributes to mitochondrial Sirt3 upregulation. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33202281&form=6&db=m Vinpocetine ameliorates L-arginine induced acute pancreatitis via Sirt1/Nrf2/TNF pathway and inhibition of oxidative stress, inflammation, and apoptosis. ongoing research,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33507132&form=6&db=m MiR-34a reverses radiation resistance on ECA-109 cells by inhibiting PI3K/AKT/mTOR signal pathway through downregulating the expression of SIRT1. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33566315&form=6&db=m Sirtuin2 correlates with lymph node metastasis, increased FIGO stage, worse overall survival, and reduced chemosensitivity to cisplatin and paclitaxel in endometrial cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33576215&form=6&db=m Selective Cytotoxicity of Kaempferia parviflora Extracts in Human Cell Lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33650791&form=6&db=m SIRT1 is involved in adrenocortical cancer growth and motility. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33669567&form=6&db=m Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33684691&form=6&db=m Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33777209&form=6&db=m MicroRNA-217 inhibits the proliferation and invasion, and promotes apoptosis of non-small cell lung cancer cells by targeting sirtuin 1. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33781187&form=6&db=m Natural Sirtuin Modulators in Drug Discovery: A Review (2010 -2020). causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33854041&form=6&db=m Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis. diagnostic usage,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33907836&form=6&db=m Role of SIRT1/AMPK signaling in the proliferation, migration and invasion of renal cell carcinoma cells. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33917352&form=6&db=m Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging-A Systematic Review. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33986372&form=6&db=m Drug repurposing for ligand-induced rearrangement of Sirt2 active site-based inhibitors via molecular modeling and quantum mechanics calculations. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34034499&form=6&db=m Circ-sirt1 inhibits growth and invasion of gastric cancer by sponging miR-132-3p/miR-212-3p and upregulating sirt1 expression. ongoing research,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34094830&form=6&db=m Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34119539&form=6&db=m Silent information regulator 1 suppresses epithelial-to-mesenchymal transition in lung cancer cells via its regulation of mitochondria status. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34147543&form=6&db=m Trending topics of SIRT1 in tumorigenicity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34177214&form=6&db=m Metal-binding effects of sirtuin inhibitor sirtinol. ongoing research,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34216621&form=6&db=m Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34226501&form=6&db=m Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34232204&form=6&db=m SIRT3 acts as a novel biomarker for the diagnosis of lung cancer: A retrospective study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34303869&form=6&db=m Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34322899&form=6&db=m Histone Deacetylase SIRT1 promotes loss of primary cilia in Cholangiocarcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34397875&form=6&db=m Serum levels of SIRT3 and other inflammatory factors are associated with clinical outcomes and prognosis in severe community-acquired pneumonia in adults: A prospective study. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34428482&form=6&db=m Melatonin rescues the mice brain against cisplatin-induced neurodegeneration, an insight into antioxidant and anti-inflammatory effects. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34440260&form=6&db=m The Histone Variant MacroH2A1 Impacts Circadian Gene Expression and Cell Phenotype in an In Vitro Model of Hepatocellular Carcinoma. causal interaction,unassigned 3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34476599&form=6&db=m Sirtuin 2 promotes cell stemness and MEK/ERK signaling pathway while reduces chemosensitivity in endometrial cancer. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24570024&form=6&db=m SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosus. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Nephrolithiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30714469&form=6&db=m Association of sirtuin 1 gene polymorphisms with nephrolithiasis in Eastern chinese population. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Nephrosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24136919&form=6&db=m Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21791548&form=6&db=m The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23570735&form=6&db=m Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25349639&form=6&db=m SIRT2 plays a key role in both cell cycle regulation and cell survival of BV2 microglia. ongoing research,unassigned 3,0 2.3.1.286 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27796760&form=6&db=m Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27942908&form=6&db=m Could Sirtuin Activities Modify ALS Onset and Progression? causal interaction,diagnostic usage,unassigned 3,1,0 2.3.1.286 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29654491&form=6&db=m SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.3.1.286 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33021962&form=6&db=m SIRT1 activation by minocycline on regulation of microglial polarization homeostasis. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23336442&form=6&db=m Synergistic interaction between total glucosides and total flavonoids on chronic constriction injury induced neuropathic pain in rats. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32126145&form=6&db=m Down-regulation of microRNA-34c-5p alleviates neuropathic pain via the SIRT1/STAT3 signaling pathway in rat models of chronic constriction injury of sciatic nerve. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33009636&form=6&db=m Intrathecal Injection of SIRT1-modified Human Mesenchymal Stem Cells Alleviates Neuropathic Pain in Rat. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33897435&form=6&db=m Sirt2 in the Spinal Cord Regulates Chronic Neuropathic Pain Through Nrf2-Mediated Oxidative Stress Pathway in Rats. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19285077&form=6&db=m SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a. causal interaction,ongoing research,unassigned 3,3,0 2.3.1.286 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21698133&form=6&db=m SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22819792&form=6&db=m SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23357110&form=6&db=m Insulin induces neurite outgrowth via SIRT1 in SH-SY5Y cells. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24874077&form=6&db=m Leptin attenuates BACE1 expression and amyloid-? genesis via the activation of SIRT1 signaling pathway. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26456643&form=6&db=m Nicotinamide N-methyltransferase increases complex I activity in SH-SY5Y cells via sirtuin 3. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27522594&form=6&db=m Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16219030&form=6&db=m Neuronal protection by sirtuins in Alzheimer's disease. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18027980&form=6&db=m Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18221243&form=6&db=m Modulation of sirtuins: new targets for antiageing. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18985648&form=6&db=m Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19663498&form=6&db=m Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19912989&form=6&db=m Is systemic activation of Sirt1 beneficial for ageing-associated metabolic disorders? causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20074616&form=6&db=m Effects of age and gender on Sirt 1 mRNA expressions in the hypothalamus of the mouse. causal interaction,unassigned 3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20306310&form=6&db=m Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20569238&form=6&db=m Sirt1’s beneficial roles in neurodegenerative diseases - a chaperonin containing TCP-1 (CCT) connection? causal interaction,unassigned 3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20655472&form=6&db=m SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. causal interaction,unassigned 3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20848588&form=6&db=m Therapeutic potential of activators and inhibitors of sirtuins. therapeutic application,unassigned 3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21791548&form=6&db=m The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21826702&form=6&db=m Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling. causal interaction,unassigned 3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22613205&form=6&db=m Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22746324&form=6&db=m Synthesis and Evaluation of Substituted Chroman-4-one and Chromone Derivatives as Sirtuin 2-Selective Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22819792&form=6&db=m SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23075334&form=6&db=m Sirtuins and renal diseases: relationship with aging and diabetic nephropathy. causal interaction,unassigned 3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23293585&form=6&db=m SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23361587&form=6&db=m Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,4 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23615921&form=6&db=m Brain Activation of SIRT1: Role in Neuropathology. causal interaction,unassigned 3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23973301&form=6&db=m Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway. therapeutic application,unassigned 3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24130928&form=6&db=m Effects of Resveratrol and trans-3,5,4'-Trimethoxystilbene on Glutamate-Induced Cytotoxicity, Heme Oxygenase-1, and Sirtuin 1 in HT22 Neuronal Cells. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24252177&form=6&db=m Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24389023&form=6&db=m Structural basis for potent inhibition of SIRT2 deacetylase by a macrocyclic peptide inducing dynamic structural change. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25281273&form=6&db=m Role of SIRT1 in autoimmune demyelination and neurodegeneration. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25386563&form=6&db=m Renal protective effect of sirtuin 1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25608039&form=6&db=m The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26546505&form=6&db=m SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-?B p65 acetylation and activation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27875273&form=6&db=m SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation. causal interaction,unassigned 3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28301150&form=6&db=m Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure-Activity Relationship Analysis. causal interaction,unassigned 3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28634345&form=6&db=m Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28634568&form=6&db=m Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28721811&form=6&db=m Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29102593&form=6&db=m Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer's disease. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30416425&form=6&db=m Sirtuins in Neuroendocrine Regulation and Neurological Diseases. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31373792&form=6&db=m A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31373965&form=6&db=m Effects of Sirtuin 1 on microglia in spinal cord injury: involvement of Wnt/?-catenin signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31545894&form=6&db=m Aberrant Decrease of the Endogenous SIRT3 and Increases of Acetylated Proteins in Scrapie Infected Cell Line SMB-S15 and in the Brains of Experimental Mice. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31740222&form=6&db=m The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders. therapeutic application,unassigned 3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31780922&form=6&db=m SIRT3 Regulation of Mitochondrial Quality Control in Neurodegenerative Diseases. causal interaction,unassigned 3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31931835&form=6&db=m Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway. causal interaction,unassigned 3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31973227&form=6&db=m Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32007785&form=6&db=m Protocatechuic acid inhibits inflammatory responses in LPS-activated BV2 microglia via regulating SIRT1/NF-?B pathway contributed to the suppression of microglial activation-induced PC12 cell apoptosis. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33041785&form=6&db=m Hydroxysafflor Yellow A Exerts Anti-Inflammatory Effects Mediated by SIRT1 in Lipopolysaccharide-Induced Microglia Activation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33444675&form=6&db=m Nutraceutical based SIRT3 activators as therapeutic targets in Alzheimer's disease. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33460497&form=6&db=m The role of PARP1 in neurodegenerative diseases and aging. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33541361&form=6&db=m Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33781187&form=6&db=m Natural Sirtuin Modulators in Drug Discovery: A Review (2010 -2020). causal interaction,unassigned 3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33986372&form=6&db=m Drug repurposing for ligand-induced rearrangement of Sirt2 active site-based inhibitors via molecular modeling and quantum mechanics calculations. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23973301&form=6&db=m Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway. therapeutic application,unassigned 3,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24013120&form=6&db=m The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26546505&form=6&db=m SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-?B p65 acetylation and activation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27165717&form=6&db=m Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28656393&form=6&db=m Emerging Roles of Sirtuins in Ischemic Stroke. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29634925&form=6&db=m Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30022380&form=6&db=m All Trans Retinoic Acid Attenuates Markers of Neuroinflammation in Rat Brain by Modulation of SIRT1 and NF?B. causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30953735&form=6&db=m Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30972182&form=6&db=m The role of SIRT1 in neuroinflammation and cognitive dysfunction in aged rats after anesthesia and surgery. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31004314&form=6&db=m Microglia activation induces oxidative injury and decreases SIRT3 expression in dopaminergic neuronal cells. causal interaction,unassigned 3,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31373965&form=6&db=m Effects of Sirtuin 1 on microglia in spinal cord injury: involvement of Wnt/?-catenin signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31631063&form=6&db=m Sirtuin 3 attenuates neuroinflammation-induced apoptosis in BV-2 microglia. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31786712&form=6&db=m AGK2 Alleviates Lipopolysaccharide Induced Neuroinflammation through Regulation of Mitogen-Activated Protein Kinase Phosphatase-1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31858862&form=6&db=m Yes-associated protein reduces neuroinflammation through upregulation of Sirt3 and inhibition of JNK signaling pathway. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32385942&form=6&db=m 5-Heptadecylresorcinol, a Biomarker for Whole Grain Rye Consumption, Ameliorates Cognitive Impairments and Neuroinflammation in APP/PS1 Transgenic Mice. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32625056&form=6&db=m Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices. causal interaction,unassigned 3,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33460497&form=6&db=m The role of PARP1 in neurodegenerative diseases and aging. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33541361&form=6&db=m Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33830639&form=6&db=m Sirtuin 1 alleviates neuroinflammation-induced apoptosis after traumatic brain injury. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,3,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34029668&form=6&db=m Resveratrol attenuates manganese-induced oxidative stress and neuroinflammation through SIRT1 signaling in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34530866&form=6&db=m NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1? pathway. ongoing research,unassigned 3,0 2.3.1.286 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28166441&form=6&db=m Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2 2.3.1.286 Nijmegen Breakage Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33239236&form=6&db=m Impairment of sirtuin 1-mediated DNA repair is involved in bisphenol A-induced aggravation of macrophage inflammation and atherosclerosis. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17498258&form=6&db=m The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17785073&form=6&db=m [Effects of calorie restriction on SIRT1 expression in liver of nonalcoholic fatty liver disease: experiment with rats] causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19724016&form=6&db=m Treatment with SRT1720, a SIRT1 Activator, Ameliorates Fatty Liver with Reduced Expression of Lipogenic Enzymes in MSG Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20033348&form=6&db=m SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22588935&form=6&db=m [Hepatic SIRT1 and UCP2 expressions in rats with type 2 diabetes mellitus and nonalcoholic fatty liver]. ongoing research,unassigned 3,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24071688&form=6&db=m [Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver.] causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24570955&form=6&db=m Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats. causal interaction,unassigned 3,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25361925&form=6&db=m Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26330104&form=6&db=m Effect of miR-34a in regulating steatosis by targeting PPAR? expression in nonalcoholic fatty liver disease. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27824080&form=6&db=m Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity. causal interaction,unassigned 3,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28437863&form=6&db=m Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28899784&form=6&db=m MiR-181b regulates steatosis in nonalcoholic fatty liver disease via targeting SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28942443&form=6&db=m A Novel Role of SIRT1/ FGF-21 in Taurine Protection Against Cafeteria Diet-Induced Steatohepatitis in Rats. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29104641&form=6&db=m Targeting Sirt1 in a rat model of high-fat diet-induced non-alcoholic fatty liver disease: Comparison of Gegen Qinlian decoction and resveratrol. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29189974&form=6&db=m Association of SIRT1 gene polymorphism and its expression for the risk of alcoholic fatty liver disease in the Han population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29903170&form=6&db=m [Association of single nucleotide polymorphism of SIRT1 and APOC3 with nonalcoholic fatty liver disease]. diagnostic usage,therapeutic application,unassigned 3,1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30525304&form=6&db=m SIRT3 Deficiency Promotes High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Correlation with Impaired Intestinal Permeability through Gut Microbial Dysbiosis. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30557833&form=6&db=m Treating hyperuricemia related non-alcoholic fatty liver disease in rats with resveratrol. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30664220&form=6&db=m SIRT1 mediates the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPAR?/FoxO1 signaling pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30861258&form=6&db=m Inhibition of microRNA-124a attenuates non-alcoholic fatty liver disease through upregulation of adipose triglyceride lipase and the effect of liraglutide intervention. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31197036&form=6&db=m Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease. causal interaction,unassigned 3,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31252266&form=6&db=m Gender effect of hyperuricemia on the development of nonalcoholic fatty liver disease (NAFLD): A clinical analysis and mechanistic study. causal interaction,unassigned 3,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32331890&form=6&db=m Sirtuin 3 improves fatty acid metabolism in response to high nonesterified fatty acids in calf hepatocytes by modulating gene expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33343352&form=6&db=m Hepatoprotective Effect and Molecular Mechanisms of Hengshun Aromatic Vinegar on Non-Alcoholic Fatty Liver Disease. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34183378&form=6&db=m Silybin Restored CYP3A Expression through the Sirtuin 2/Nuclear Factor ?-B Pathway in Mouse Nonalcoholic Fatty Liver Disease. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18027980&form=6&db=m Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19724016&form=6&db=m Treatment with SRT1720, a SIRT1 Activator, Ameliorates Fatty Liver with Reduced Expression of Lipogenic Enzymes in MSG Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19741164&form=6&db=m SIRT1 genetic variation is related to body mass index and risk of obesity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20020036&form=6&db=m Hypothalamic Sirt1 regulates food intake in a rodent model system. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20620997&form=6&db=m SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20823772&form=6&db=m Resveratrol: a relevant pharmacological approach for the treatment of metabolic syndrome? causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21483037&form=6&db=m Resveratrol-activated SIRT1 in liver and pancreatic ?-cells: a Janus head looking to the same direction of metabolic homeostasis. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21856199&form=6&db=m SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22310473&form=6&db=m SIRT1 and CLOCK 3111T>C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22382036&form=6&db=m Metabolic actions of hypothalamic SIRT1. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22613205&form=6&db=m Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22640422&form=6&db=m Metabolic programming of sirtuin 1 (SIRT1) expression by moderate energy restriction during gestation in rats may be related to obesity susceptibility in later life. causal interaction,unassigned 3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22986685&form=6&db=m Indole-3-carbinol directly targets SIRT1 to inhibit adipocyte differentiation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23776383&form=6&db=m Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23880847&form=6&db=m (Healthy) ageing: focus on iodothyronines. causal interaction,unassigned 3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23970286&form=6&db=m Diet-induced obesity promotes murine gastric cancer growth through a nampt/sirt1/c-myc positive feedback loop. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25000096&form=6&db=m Structure-based drug design of small molecule SIRT1 modulators to treat cancer and metabolic disorders. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25109279&form=6&db=m Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25670718&form=6&db=m Visfatin/Nampt and SIRT1: Roles in Postterm Delivery in Pregnancies Associated With Obesity. causal interaction,unassigned 3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25790176&form=6&db=m Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes. causal interaction,ongoing research,unassigned 3,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25973386&form=6&db=m Adipocyte SIRT1 knockout promotes PPAR? activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26105582&form=6&db=m Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26330758&form=6&db=m Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26667041&form=6&db=m Sirtuins-mediators of maternal obesity-induced complications in offspring? causal interaction,unassigned 3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26818519&form=6&db=m Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26916242&form=6&db=m Diet-induced obesity and insulin resistance are associated with brown fat degeneration in SIRT1-deficient mice. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27320865&form=6&db=m Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27356800&form=6&db=m [Effect of SIRT1 deficiency on function of brown adipose tissue in obese mice]. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27592202&form=6&db=m Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding. causal interaction,unassigned 3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28118644&form=6&db=m The Gender Association of the SIRT1 rs7895833 Polymorphism with Pediatric Obesity: A 3-Year Panel Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28329774&form=6&db=m [Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28973648&form=6&db=m The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29417372&form=6&db=m Adipose tissue, but not skeletal muscle, sirtuin 1 expression is decreased in obesity and related to insulin sensitivity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29535452&form=6&db=m ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30355082&form=6&db=m Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30641770&form=6&db=m Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31936019&form=6&db=m SIRT3 Acts as a Positive Autophagy Regulator to Promote Lipid Mobilization in Adipocytes via Activating AMPK. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31949600&form=6&db=m MiR-30a-5p accelerates adipogenesis by negatively regulating Sirtuin 1. therapeutic application,unassigned 3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32152092&form=6&db=m Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia. causal interaction,unassigned 3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32212196&form=6&db=m Sirt3 is dispensable for oocyte quality and female fertility in lean and obese mice. therapeutic application,unassigned 3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32321406&form=6&db=m In silico Design of Novel Sirtuin 1 Enzyme Activators for Treatment of Age-related Diseases and Life Span. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32723184&form=6&db=m Stimulation of brown adipose tissue by polyphenols in extra virgin olive oil. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32888158&form=6&db=m LncRNA TUG1 reduces inflammation and enhances insulin sensitivity in white adipose tissue by regulating miR-204/SIRT1 axis in obesity mice. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33572672&form=6&db=m Hypothalamic Actions of SIRT1 and SIRT6 on Energy Balance. causal interaction,unassigned 3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33901577&form=6&db=m Silymarin ameliorates the disordered glucose metabolism of mice with diet-induced obesity by activating the hepatic SIRT1 pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34296964&form=6&db=m Sex differences in the impact of parental obesity on offspring cardiac SIRT3 expression, mitochondrial efficiency, and diastolic function early in life. causal interaction,unassigned 3,0 2.3.1.286 Obesity, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28329774&form=6&db=m [Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 2.3.1.286 Optic Atrophy, Autosomal Dominant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34181898&form=6&db=m Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Optic Nerve Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23293585&form=6&db=m SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Optic Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26885868&form=6&db=m The involvement of sirtuins during optic nerve injury of rats. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Optic Neuritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17652729&form=6&db=m SIRT1 activation confers neuroprotection in experimental optic neuritis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Optic Neuritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23293585&form=6&db=m SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20979093&form=6&db=m Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21337390&form=6&db=m Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23276927&form=6&db=m Towards elucidating the role of SirT1 in osteoarthritis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23844973&form=6&db=m Resveratrol, a sirtuin 1 activator, increases IL-6 production by peripheral blood mononuclear cells of patients with knee osteoarthritis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27289467&form=6&db=m The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28586000&form=6&db=m Underlying mechanism of Sirt1 on apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes. ongoing research,unassigned 3,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29201214&form=6&db=m Sirt1 regulates apoptosis and extracellular matrix degradation in resveratrol-treated osteoarthritis chondrocytes via the Wnt/?-catenin signaling pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,1 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29413962&form=6&db=m Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis. causal interaction,unassigned 3,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31989845&form=6&db=m Inhibition of Knee Osteoarthritis Progression in Mice by Administering SRT2014, an Activator of Silent Information Regulator 2 Ortholog 1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34078001&form=6&db=m Ferulic acid suppresses interleukin-1?-induced degeneration of chondrocytes isolated from patients with osteoarthritis through the SIRT1/AMPK/PGC-1? signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23844973&form=6&db=m Resveratrol, a sirtuin 1 activator, increases IL-6 production by peripheral blood mononuclear cells of patients with knee osteoarthritis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31989845&form=6&db=m Inhibition of Knee Osteoarthritis Progression in Mice by Administering SRT2014, an Activator of Silent Information Regulator 2 Ortholog 1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.3.1.286 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28553103&form=6&db=m The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-?B deacetylation in aseptic loosening. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Osteonecrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32395770&form=6&db=m miR-122/SIRT1 axis regulates chondrocyte extracellular matrix degradation in osteoarthritis. causal interaction,unassigned 3,0 2.3.1.286 Osteonecrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33453243&form=6&db=m SIRT1, a promising regulator of bone homeostasis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19333775&form=6&db=m Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice. causal interaction,unassigned 3,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21952235&form=6&db=m Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23104101&form=6&db=m Seven sirtuins for seven deadly diseases of aging. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23276927&form=6&db=m Towards elucidating the role of SirT1 in osteoarthritis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25002589&form=6&db=m Sirtuin1 (Sirt1) Promotes Cortical Bone Formation by Preventing ?-Catenin Sequestration by FoxO Transcription Factors in Osteoblast Progenitors. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26226624&form=6&db=m The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27422605&form=6&db=m MiR-132 regulates osteogenic differentiation via downregulating Sirtuin1 in a peroxisome proliferator-activated receptor ?/?-dependent manner. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28911171&form=6&db=m Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28937996&form=6&db=m SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30318050&form=6&db=m Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30862606&form=6&db=m Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders? causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,4 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31804494&form=6&db=m The Role and Mechanism of SIRT1 in Resveratrol-regulated Osteoblast Autophagy in Osteoporosis Rats. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33453243&form=6&db=m SIRT1, a promising regulator of bone homeostasis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Osteoporosis, Postmenopausal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32410477&form=6&db=m 17?-Estradiol improves osteoblastic cell function through the Sirt1/NF-?B/MMP-8 pathway. therapeutic application,unassigned 3,0 2.3.1.286 Osteoporosis, Postmenopausal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33359008&form=6&db=m Deletion of SIRT3 inhibits osteoclastogenesis and alleviates aging or estrogen deficiency-induced bone loss in female mice. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23726949&form=6&db=m SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28059051&form=6&db=m MicroRNA-133b Inhibits Cell Proliferation and Invasion in Osteosarcoma by Targeting Sirt1. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28587420&form=6&db=m Suppressive effect of microRNA-138 on the proliferation and invasion of osteosarcoma cells via targeting SIRT1. ongoing research,unassigned 3,0 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28632727&form=6&db=m Post-translational regulation contributes to the loss of LKB1 expression through SIRT1 deacetylase in osteosarcomas. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31390921&form=6&db=m Sirt1 modulates H3 phosphorylation and facilitates osteosarcoma cell autophagy. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31608237&form=6&db=m Sirtuin Family Members Selectively Regulate Autophagy in Osteosarcoma and Mesothelioma Cells in Response to Cellular Stress. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33777209&form=6&db=m MicroRNA-217 inhibits the proliferation and invasion, and promotes apoptosis of non-small cell lung cancer cells by targeting sirtuin 1. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21407215&form=6&db=m Multifunctional transcription factor TFII-I is an activator of BRCA1 function. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26992208&form=6&db=m Distinct effects of SIRT1 in cancer and stromal cells on tumor promotion. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28259910&form=6&db=m Reduced expression of SIRT2 in serous ovarian carcinoma promotes cell proliferation through disinhibition of CDK4 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28365935&form=6&db=m Selecting key genes associated with ovarian cancer based on differential expression network. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28888043&form=6&db=m SIRT1 deacetylates KLF4 to activate Claudin-5 transcription in ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30598658&form=6&db=m The plasma peptides of ovarian cancer. diagnostic usage,unassigned 3,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31723239&form=6&db=m Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32046380&form=6&db=m Differential Expression of KRAS and SIRT1 in Ovarian Cancers with and Without Endometriosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32541517&form=6&db=m Gene expression and prognosis of sirtuin family members in ovarian cancer. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Overnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22110092&form=6&db=m SirT1 regulates adipose tissue inflammation. causal interaction,unassigned 3,0 2.3.1.286 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23800577&form=6&db=m Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation. diagnostic usage,therapeutic application,unassigned 3,1,0 2.3.1.286 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25680002&form=6&db=m Aerobic Training Increases Expression Levels of SIRT3 and PGC-1? in Skeletal Muscle of Overweight Adolescents Without Change in Caloric Intake. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29417372&form=6&db=m Adipose tissue, but not skeletal muscle, sirtuin 1 expression is decreased in obesity and related to insulin sensitivity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30641770&form=6&db=m Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27494892&form=6&db=m Sirtuin1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28052003&form=6&db=m miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32441762&form=6&db=m SIRT1-NOX4 signaling axis regulates cancer cachexia. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Papillomavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31762241&form=6&db=m [Expression Level of SIRT2 in Cervical Cancer Tissue and Its Clinical Significance]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3 2.3.1.286 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29201361&form=6&db=m Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism. therapeutic application,unassigned 3,0 2.3.1.286 Parasitic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28241112&form=6&db=m Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives. therapeutic application,unassigned 3,0 2.3.1.286 Parasitic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29357372&form=6&db=m Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22613205&form=6&db=m Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23570735&form=6&db=m Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23719790&form=6&db=m Genetic association of sirtuin genes and Parkinson's disease. causal interaction,unassigned 3,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23973301&form=6&db=m Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway. therapeutic application,unassigned 3,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24922350&form=6&db=m SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells. causal interaction,unassigned 3,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25395356&form=6&db=m The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25608039&form=6&db=m The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26982234&form=6&db=m 5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27158385&form=6&db=m MicroRNA-7 inhibits neuronal apoptosis in a cellular Parkinson's disease model by targeting Bax and Sirt2. therapeutic application,unassigned 3,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27796760&form=6&db=m Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28634568&form=6&db=m Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29654491&form=6&db=m SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30364275&form=6&db=m MicroRNA-212-5p Prevents Dopaminergic Neuron Death by Inhibiting SIRT2 in MPTP-Induced Mouse Model of Parkinson's Disease. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31105527&form=6&db=m Inhibition of SIRT2 by Targeting GSK3?-Mediated Phosphorylation Alleviates SIRT2 Toxicity in SH-SY5Y Cells. causal interaction,unassigned 3,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31998119&form=6&db=m Emerging Role of Sirtuin 2 in Parkinson's Disease. causal interaction,unassigned 3,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32591930&form=6&db=m Design and in vitro analysis of SIRT2 inhibitor targeting Parkinson's disease. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Pediatric Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28118644&form=6&db=m The Gender Association of the SIRT1 rs7895833 Polymorphism with Pediatric Obesity: A 3-Year Panel Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 2.3.1.286 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31749165&form=6&db=m Influence of the treatment of periodontal disease in serum concentration of sirtuin 1 and mannose-binding lectin. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25091897&form=6&db=m Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30026098&form=6&db=m Sirt1 alleviates LPS induced inflammation of periodontal ligament fibroblasts via downregulation of TLR4. ongoing research,unassigned 3,0 2.3.1.286 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31769563&form=6&db=m Nicotinamide-induced silencing of SIRT1 by miR-22-3p increases periodontal ligament stem cell proliferation and differentiation. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33897435&form=6&db=m Sirt2 in the Spinal Cord Regulates Chronic Neuropathic Pain Through Nrf2-Mediated Oxidative Stress Pathway in Rats. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31208524&form=6&db=m Role of mitochondria in diabetic peripheral neuropathy: Influencing the NAD+-dependent SIRT1-PGC-1?-TFAM pathway. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28634345&form=6&db=m Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.3.1.286 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30217997&form=6&db=m MiR-199a-5p regulates sirtuin1 and PI3K in the rat hippocampus with intrauterine growth restriction. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22178470&form=6&db=m SIRT1 as a therapeutic target in inflammaging of the pulmonary disease. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28634345&form=6&db=m Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.3.1.286 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30918470&form=6&db=m Ginsenoside Rg1 Regulates SIRT1 to Ameliorate Sepsis-Induced Lung Inflammation and Injury via Inhibiting Endoplasmic Reticulum Stress and Inflammation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32360040&form=6&db=m Curcumin Attenuates Hemorrhagic Shock and Blood Replenish Resuscitation-induced Impairment of Pulmonary Barrier Function by Increasing SIRT1 and Reducing Malondialdehyde and TNF-? Contents and Neutrophil Infiltration in Lung in a Dose-Dependent Fashion. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.3.1.286 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34397875&form=6&db=m Serum levels of SIRT3 and other inflammatory factors are associated with clinical outcomes and prognosis in severe community-acquired pneumonia in adults: A prospective study. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.286 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33864594&form=6&db=m Evaluation of sirtuin 1 (SIRT1) levels in autosomal dominant polycystic kidney disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 2.3.1.286 Polycystic Kidney, Autosomal Dominant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33864594&form=6&db=m Evaluation of sirtuin 1 (SIRT1) levels in autosomal dominant polycystic kidney disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 2.3.1.286 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29447380&form=6&db=m Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Polycythemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32276962&form=6&db=m Role of Impaired Nutrient and Oxygen Deprivation Signaling and Deficient Autophagic Flux in Diabetic CKD Development: Implications for Understanding the Effects of Sodium-Glucose Cotransporter 2-Inhibitors. causal interaction,unassigned 3,0 2.3.1.286 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34402258&form=6&db=m Advances in the role of silence information regulator family in pathological pregnancy. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26416354&form=6&db=m Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28249909&form=6&db=m Morphoproteomics Identifies SIRT1 and EZH2 Pathways as Commonalities in B-cell Acute Lymphoblastic Leukemia: Pathogenetic Implications and Opportunities for Therapeutic Intervention. therapeutic application,unassigned 3,0 2.3.1.286 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28329774&form=6&db=m [Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 2.3.1.286 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32487610&form=6&db=m Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-?B Pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32487610&form=6&db=m Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-?B Pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Pregnancy Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34402258&form=6&db=m Advances in the role of silence information regulator family in pathological pregnancy. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Presbycusis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24505357&form=6&db=m Age-related decrease in the mitochondrial sirtuin deacetylase Sirt3 expression associated with ROS accumulation in the auditory cortex of the mimetic aging rat model. causal interaction,unassigned 3,0 2.3.1.286 Primary Ovarian Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33164435&form=6&db=m [Effect of SIRT1 on delay of D-gal-induced premature ovarian failure in mice with ginsenoside Rg_1]. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Prion Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31545894&form=6&db=m Aberrant Decrease of the Endogenous SIRT3 and Increases of Acetylated Proteins in Scrapie Infected Cell Line SMB-S15 and in the Brains of Experimental Mice. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Progeria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27875273&form=6&db=m SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation. causal interaction,unassigned 3,0 2.3.1.286 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21189328&form=6&db=m Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.3.1.286 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24127549&form=6&db=m Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17505061&form=6&db=m Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18573234&form=6&db=m A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19075016&form=6&db=m Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21062352&form=6&db=m Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21189328&form=6&db=m Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22249256&form=6&db=m SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23169992&form=6&db=m SIRT1 represses estrogen-signaling, ligand-independent ER?-mediated transcription, and cell proliferation in estrogen-responsive breast cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24127549&form=6&db=m Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24713434&form=6&db=m Global transcriptome analysis of formalin-fixed prostate cancer specimens identifies biomarkers of disease recurrence. causal interaction,unassigned 3,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24892674&form=6&db=m Down-regulation of mir-221 and mir-222 restrain prostate cancer cell proliferation and migration that is partly mediated by activation of SIRT1. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25557355&form=6&db=m Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes. ongoing research,unassigned 3,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26847404&form=6&db=m Effect of SIRT1 Gene on Epithelial-Mesenchymal Transition of Human Prostate Cancer PC-3 Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26996298&form=6&db=m Leptin contributes to long-term stabilization of HIF-1? in cancer cells subjected to oxygen limiting conditions. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28108513&form=6&db=m RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells. ongoing research,unassigned 3,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28329774&form=6&db=m [Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29100388&form=6&db=m Sirtuin 7: a new marker of aggressiveness in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29228612&form=6&db=m MiR-204 enhances mitochondrial apoptosis in doxorubicin-treated prostate cancer cells by targeting SIRT1/p53 pathway. causal interaction,unassigned 3,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33576215&form=6&db=m Selective Cytotoxicity of Kaempferia parviflora Extracts in Human Cell Lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33777209&form=6&db=m MicroRNA-217 inhibits the proliferation and invasion, and promotes apoptosis of non-small cell lung cancer cells by targeting sirtuin 1. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 Prostatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28648062&form=6&db=m Resveratrol Improved the Progression of Chronic Prostatitis via the Downregulation of c-kit/SCF by Activating Sirt1. causal interaction,unassigned 3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21856199&form=6&db=m SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23075334&form=6&db=m Sirtuins and renal diseases: relationship with aging and diabetic nephropathy. causal interaction,unassigned 3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24047466&form=6&db=m Sirt3 Deficiency Does not Augment Hypoxia-Induced Pulmonary Hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24136919&form=6&db=m Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24748594&form=6&db=m SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts. causal interaction,unassigned 3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25646749&form=6&db=m SIRT1 plays a Protective role in Intervertebral Disc Degeneration in a Puncture-Induced Rodent model. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26226624&form=6&db=m The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27125275&form=6&db=m Inhibition of SIRT2 suppresses hepatic fibrosis. causal interaction,unassigned 3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27356800&form=6&db=m [Effect of SIRT1 deficiency on function of brown adipose tissue in obese mice]. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28634345&form=6&db=m Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29214052&form=6&db=m Neuroprotective role of retinal SIRT3 against acute photo-stress. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29898623&form=6&db=m Depletion of Sirt3 leads to the impairment of adipogenic differentiation and insulin resistance via interfering mitochondrial function of adipose-derived human mesenchymal stem cells. causal interaction,ongoing research,unassigned 3,3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30443190&form=6&db=m SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis. causal interaction,unassigned 3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30445165&form=6&db=m Maternal eicosapentaenoic acid feeding promotes placental angiogenesis through a Sirtuin-1 independent inflammatory pathway. causal interaction,unassigned 3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30471862&form=6&db=m Effects of myeloid sirtuin 1 deficiency on hypothalamic neurogranin in mice fed a high-fat diet. ongoing research,unassigned 3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30525304&form=6&db=m SIRT3 Deficiency Promotes High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Correlation with Impaired Intestinal Permeability through Gut Microbial Dysbiosis. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31340681&form=6&db=m Sirtuin 3 deficiency accelerates Angiotensin II-induced skeletal muscle atrophy. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31545987&form=6&db=m Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders. causal interaction,unassigned 3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31610175&form=6&db=m Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32329068&form=6&db=m SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32500353&form=6&db=m Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1?/VEGF Signaling and Blood-Brain Barrier Integrity. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32538779&form=6&db=m Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice. causal interaction,unassigned 3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32660330&form=6&db=m Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure. causal interaction,unassigned 3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32679047&form=6&db=m Inhibiting Protein Kinase Activity of Pyruvate Kinase M2 by SIRT2 Deacetylase Attenuates Psoriasis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32763411&form=6&db=m High glucose-induced PRDX3 acetylation contributes to glucotoxicity in pancreatic ?-cells: Prevention by Teneligliptin. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32770173&form=6&db=m Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33513830&form=6&db=m Intestinal SIRT1 Deficiency-Related Intestinal Inflammation and Dysbiosis Aggravate TNF?-Mediated Renal Dysfunction in Cirrhotic Ascitic Mice. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34181898&form=6&db=m Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26931472&form=6&db=m Epigenetic regulation through SIRT1 in podocytes. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30187480&form=6&db=m Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC-1? mediated attenuation of mitochondrial oxidative stress. ongoing research,unassigned 3,0 2.3.1.286 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33179827&form=6&db=m Late intervention in the remnant kidney model attenuates proteinuria but not glomerular filtration rate decline. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26556603&form=6&db=m A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis. ongoing research,therapeutic application,unassigned 3,3,0 2.3.1.286 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29799444&form=6&db=m Sirt1 Protects against Oxidative Stress-Induced Apoptosis in Fibroblasts from Psoriatic Patients: A New Insight into the Pathogenetic Mechanisms of Psoriasis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29937556&form=6&db=m The Role of Forkhead Box Class O3A and SIRT1 Gene Variants in Early-Onset Psoriasis. causal interaction,ongoing research,unassigned 3,1,0 2.3.1.286 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31017270&form=6&db=m Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7. causal interaction,ongoing research,unassigned 3,3,0 2.3.1.286 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32679047&form=6&db=m Inhibiting Protein Kinase Activity of Pyruvate Kinase M2 by SIRT2 Deacetylase Attenuates Psoriasis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32825671&form=6&db=m Histone Deacetylase 1 and Sirtuin 1 Expression in Psoriatic Skin: A Comparison between Guttate and Plaque Psoriasis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23324252&form=6&db=m Different patterns of lung sirtuin expression in smokers with and without chronic obstructive pulmonary disease. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25304127&form=6&db=m Role of sirtuins in chronic obstructive pulmonary disease. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28339038&form=6&db=m LncRNA?mediated SIRT1/FoxO3a and SIRT1/p53 signaling pathways regulate type II alveolar epithelial cell senescence in patients with chronic obstructive pulmonary disease. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28506610&form=6&db=m Decreased Serum Sirtuin-1 in COPD. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30673309&form=6&db=m Melatonin protects against COPD by attenuating apoptosis and endoplasmic reticulum stress via upregulating SIRT1 expression in rats. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31762195&form=6&db=m Role of melatonin as an SIRT1 enhancer in chronic obstructive pulmonary disease induced by cigarette smoke. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32270742&form=6&db=m Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32523885&form=6&db=m Effects of conjugated linoleic acid supplementation on serum levels of interleukin-6 and sirtuin 1 in COPD patients. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32819170&form=6&db=m SIRT1 attenuates endoplasmic reticulum stress and apoptosis in rat models of COPD. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.3.1.286 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30390331&form=6&db=m Targeting anti-aging protein sirtuin (Sirt) in the diagnosis of idiopathic pulmonary fibrosis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34202229&form=6&db=m SIRT3 Overexpression Ameliorates Asbestos-Induced Pulmonary Fibrosis, mt-DNA Damage, and Lung Fibrogenic Monocyte Recruitment. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Purpura, Thrombocytopenic, Idiopathic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34269838&form=6&db=m SIRT1 single-nucleotide polymorphisms are associated with corticosteroid sensitivity in primary immune thrombocytopenia patients. diagnostic usage,therapeutic application,unassigned 3,1,0 2.3.1.286 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31028741&form=6&db=m Bouchardatine suppresses rectal cancer in mice by disrupting its metabolic pathways via activating the SIRT1-PGC-1?-UCP2 axis. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25386563&form=6&db=m Renal protective effect of sirtuin 1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31637223&form=6&db=m The decreased SIRT1 level may account for the lipid profile in chronic kidney disease. causal interaction,diagnostic usage,unassigned 3,1,0 2.3.1.286 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33790547&form=6&db=m Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24748594&form=6&db=m SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts. causal interaction,unassigned 3,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26963320&form=6&db=m Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27393852&form=6&db=m SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28457391&form=6&db=m Cross-Talk Between Sirtuin 1 and High-Mobility Box 1 in Steatotic Liver Graft Preservation. causal interaction,unassigned 3,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29654491&form=6&db=m SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29804361&form=6&db=m [Role of short-term starvation in alleviating hepatic ischemia-reperfusion injury in mice and possible mechanism of action]. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30232347&form=6&db=m Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression. ongoing research,therapeutic application,unassigned 2,3,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30355082&form=6&db=m Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30485429&form=6&db=m The novel relationship between Sirt3 and autophagy in myocardial ischemia-reperfusion. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31178972&form=6&db=m MLN4924 Exerts a Neuroprotective Effect against Oxidative Stress via Sirt1 in Spinal Cord Ischemia-Reperfusion Injury. ongoing research,therapeutic application,unassigned 1,3,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33381707&form=6&db=m The relationship between coronary artery disease and SIRT1 protein. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 2.3.1.286 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30091035&form=6&db=m The Role of SIRT1 in Autophagy in Lipopolysaccharide-Induced Mouse Type II Alveolar Epithelial Cells. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19407027&form=6&db=m Sirt1 involvement in rd10 mouse retinal degeneration. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20829644&form=6&db=m Retinal aging and sirtuins. ongoing research,unassigned 3,0 2.3.1.286 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29214052&form=6&db=m Neuroprotective role of retinal SIRT3 against acute photo-stress. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29721988&form=6&db=m Role of Sirtuins in Retinal Function Under Basal Conditions. diagnostic usage,therapeutic application,unassigned 3,1,0 2.3.1.286 Retinal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27856259&form=6&db=m Potential suppression of the high glucose and insulin-induced retinal neovascularization by Sirtuin 3 in the human retinal endothelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.3.1.286 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19407027&form=6&db=m Sirt1 involvement in rd10 mouse retinal degeneration. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25660418&form=6&db=m Expression of SIRT2 and SIRT6 in retinoblastoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.3.1.286 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27172132&form=6&db=m Sirtuin1 Expression and Correlation with Histopathological Features in Retinoblastoma. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.286 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27991597&form=6&db=m Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury. causal interaction,unassigned 3,0 2.3.1.286 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32306906&form=6&db=m Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.3.1.286 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25341037&form=6&db=m SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.3.1.286 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24019980&form=6&db=m Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.286 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24133372&form=6&db=m The emerging and diverse roles of sirtuins in cancer: a clinical perspective. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25341037&form=6&db=m SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.3.1.286 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28929922&form=6&db=m Elevated levels of serum MiR-152 and miR-24 in uterine sarcoma: potential for inducing autophagy via SIRT1 and deacetylated LC3. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32276460&form=6&db=m ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,2,0 2.3.1.286 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33327875&form=6&db=m Sirtuin 2 in Endometrial Cancer: A Potential Regulator for Cell Proliferation, Apoptosis and RAS/ERK Pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25281719&form=6&db=m Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 2.3.1.286 Sarcoma, Synovial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25341037&form=6&db=m SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.3.1.286 Schistosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32451992&form=6&db=m Computer-Aided Drug Design for the Identification of Novel Antischistosomal Compounds. therapeutic application,unassigned 3,0 2.3.1.286 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27732568&form=6&db=m SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis. causal interaction,unassigned 3,0 2.3.1.286 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32124989&form=6&db=m Mitochondrial Sirtuins in Skin and Skin Cancers. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.286 Scrapie http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31545894&form=6&db=m Aberrant Decrease of the Endogenous SIRT3 and Increases of Acetylated Proteins in Scrapie Infected Cell Line SMB-S15 and in the Brains of Experimental Mice. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.286 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30009381&form=6&db=m Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25001863&form=6&db=m SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25051385&form=6&db=m Histone deacetylase III as a potential therapeutic target for the treatment of lethal sepsis. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25793995&form=6&db=m SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27500833&form=6&db=m Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27779675&form=6&db=m Resveratrol alleviates sepsis?induced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNF?? and myocardial apoptosis via activation of Sirt1. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27878240&form=6&db=m SirT1 activator represses the transcription of TNF?? in THP?1 cells of a sepsis model via deacetylation of H4K16. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28533769&form=6&db=m Celecoxib Enhances the Efficacy of Low-Dose Antibiotic Treatment against Polymicrobial Sepsis in Mice and Clinical Isolates of ESKAPE Pathogens. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30186119&form=6&db=m BML-111 Reduces Neuroinflammation and Cognitive Impairment in Mice With Sepsis via the SIRT1/NF-?B Signaling Pathway. causal interaction,unassigned 3,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30966773&form=6&db=m Aloin Reduces HMGB1-Mediated Septic Responses and Improves Survival in Septic Mice by Activation of the SIRT1 and PI3K/Nrf2/HO-1 Signaling Axis. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32767095&form=6&db=m Coronavirus (Covid-19) sepsis: revisiting mitochondrial dysfunction in pathogenesis, aging, inflammation, and mortality. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32771944&form=6&db=m MiRNA-133a aggravates inflammatory responses in sepsis by targeting SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32835697&form=6&db=m Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33569452&form=6&db=m Sirtuin 2 expression levels may predict the progression of sepsis survivors to chronic critical illness. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33577060&form=6&db=m Effect of miR-132 on lung injury in sepsis rats via regulating Sirt1 expression. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33770326&form=6&db=m Protective Effect of Sirtuin 3 on CLP-Induced Endothelial Dysfunction of Early Sepsis by Inhibiting NF-?B and NLRP3 Signaling Pathways. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34112288&form=6&db=m [Effects of resveratrol-mediated inhibition of NOD-like receptor protein 3 inflammasomevia activating silent information regulator 1 on the injury of intestinal mucosal barrier function after sepsis]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 2.3.1.286 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28627707&form=6&db=m Tremella fuciformis polysaccharide suppresses hydrogen peroxide-triggered injury of human skin fibroblasts via upregulation of SIRT1. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16732220&form=6&db=m Therapeutic potential of resveratrol: the in vivo evidence. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31261609&form=6&db=m The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.3.1.286 Sleep Apnea, Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26345325&form=6&db=m Effect of Nasal CPAP on SIRT1 and Endothelial Function in Obstructive Sleep Apnea Syndrome. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.286 Sleep Apnea, Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26976689&form=6&db=m Effects of nasal CPAP on exhaled SIRT1 and tumor necrosis factor-? in patients with obstructive sleep apnea. ongoing research,unassigned 3,0 2.3.1.286 Sleep Apnea, Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32267595&form=6&db=m Association between proteomics and obstructive sleep apnea phenotypes in a community-based cohort of women. causal interaction,unassigned 3,0 2.3.1.286 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31894331&form=6&db=m Sirtuin 3 induces apoptosis and necroptosis by regulating mutant p53 expression in small?cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31373965&form=6&db=m Effects of Sirtuin 1 on microglia in spinal cord injury: involvement of Wnt/?-catenin signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31859031&form=6&db=m Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21117229&form=6&db=m Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 2.3.1.286 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22674009&form=6&db=m Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 2.3.1.286 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26785117&form=6&db=m Loss of Mitochondrial Tumor Suppressor Genes Expression Is Associated with Unfavorable Clinical Outcome in Head and Neck Squamous Cell Carcinoma: Data from Retrospective Study. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.3.1.286 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31781300&form=6&db=m Determination of SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, and RAGE rs1800625 Single Gene Polymorphisms in Patients with Laryngeal Squamous Cell Carcinoma. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33727672&form=6&db=m MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 ST Elevation Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31294459&form=6&db=m MicroRNA-33 and SIRT1 influence the coronary thrombus burden in hyperglycemic STEMI patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19356714&form=6&db=m Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20071779&form=6&db=m Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. ongoing research,therapeutic application,unassigned 3,3,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23361587&form=6&db=m Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,4 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23767918&form=6&db=m Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts. causal interaction,unassigned 3,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31390921&form=6&db=m Sirt1 modulates H3 phosphorylation and facilitates osteosarcoma cell autophagy. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32703935&form=6&db=m Deacetylation of HSD17B10 by SIRT3 regulates cell growth and cell resistance under oxidative and starvation stresses. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33081014&form=6&db=m Novel Insights into the Cellular Localization and Regulation of the Autophagosomal Proteins LC3A, LC3B and LC3C. ongoing research,therapeutic application,unassigned 3,3,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23768087&form=6&db=m MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23970286&form=6&db=m Diet-induced obesity promotes murine gastric cancer growth through a nampt/sirt1/c-myc positive feedback loop. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25815791&form=6&db=m High glucose promotes gastric cancer chemoresistance in vivo and in vitro. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26049033&form=6&db=m SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26121691&form=6&db=m SIRT3 Enhances Glycolysis and Proliferation in SIRT3-Expressing Gastric Cancer Cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26612257&form=6&db=m miR-543 promotes gastric cancer cell proliferation by targeting SIRT1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28061480&form=6&db=m Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29088792&form=6&db=m Association of sirtuins with clinicopathological parameters and overall survival in gastric cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29581731&form=6&db=m MicroRNA-34a regulates proliferation and apoptosis of gastric cancer cells by targeting silent information regulator 1. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31423013&form=6&db=m SIRT1-targeted miR-543 autophagy inhibition and epithelial-mesenchymal transition promotion in Helicobacter pylori CagA-associated gastric cancer. causal interaction,unassigned 3,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34034499&form=6&db=m Circ-sirt1 inhibits growth and invasion of gastric cancer by sponging miR-132-3p/miR-212-3p and upregulating sirt1 expression. ongoing research,unassigned 3,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20306310&form=6&db=m Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20533910&form=6&db=m Icariin Inhibits Hydrogen Peroxide-Mediated Cytotoxicity by Up-regulating Sirtuin Type 1-Dependent Catalase and Peroxiredoxin. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23461657&form=6&db=m A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26620563&form=6&db=m SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY. therapeutic application,unassigned 3,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27796760&form=6&db=m Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28656393&form=6&db=m Emerging Roles of Sirtuins in Ischemic Stroke. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30544370&form=6&db=m Prognostic value of Sirtuin1 in acute ischemic stroke and its correlation with functional outcomes. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31298398&form=6&db=m Effects of rosuvastatin on neuronal apoptosis in cerebral ischemic stroke rats via Sirt1/NF-kappa B signaling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32500353&form=6&db=m Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1?/VEGF Signaling and Blood-Brain Barrier Integrity. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33155221&form=6&db=m Using ultrasound three-dimensional speckle tracking technology to explore the role of SIRT1 in ventricular remodeling after myocardial infarction. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,3 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33647420&form=6&db=m Promotion of Momordica Charantia polysaccharides on neural stem cell proliferation by increasing SIRT1 activity after cerebral ischemia/reperfusion in rats. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24482345&form=6&db=m SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28053989&form=6&db=m SIRT3 Expression Decreases with Reactive Oxygen Species Generation in Rat Cortical Neurons during Early Brain Injury Induced by Experimental Subarachnoid Hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.286 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29872034&form=6&db=m Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH). ongoing research,therapeutic application,unassigned 4,3,0 2.3.1.286 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33345851&form=6&db=m Oleanolic acid exerts neuroprotective effects in subarachnoid hemorrhage rats through SIRT1-mediated HMGB1 deacetylation. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Sudden Unexpected Death in Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30009381&form=6&db=m Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.3.1.286 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33062145&form=6&db=m Oleanolic Acid Decreases IL-1?-Induced Activation of Fibroblast-Like Synoviocytes via the SIRT3-NF-?B Axis in Osteoarthritis. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.286 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30514854&form=6&db=m A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.3.1.286 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25829495&form=6&db=m Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33275538&form=6&db=m Antioxidant and anti-inflammatory properties of alpha lipoic acid protect against valproic acid induced liver injury. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25339356&form=6&db=m Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25829495&form=6&db=m Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31141719&form=6&db=m Danhong Huayu Koufuye prevents venous thrombosis through antiinflammation via Sirtuin 1/NF-?B signaling pathway. ongoing research,unassigned 3,0 2.3.1.286 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31294459&form=6&db=m MicroRNA-33 and SIRT1 influence the coronary thrombus burden in hyperglycemic STEMI patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.3.1.286 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25109285&form=6&db=m Sirt1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,2 2.3.1.286 Thyroid Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34439776&form=6&db=m Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.286 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25109285&form=6&db=m Sirt1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,2 2.3.1.286 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26236947&form=6&db=m AMPK inhibits MTDH expression via GSK3? and SIRT1 activation: potential role in triple negative breast cancer cell proliferation. ongoing research,unassigned 3,0 2.3.1.286 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32428596&form=6&db=m Combination of sirtuin 3 and hyperoxia diminishes tumorigenic properties of MDA-MB-231 cells. ongoing research,unassigned 3,0 2.3.1.286 Trypanosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28241112&form=6&db=m Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives. therapeutic application,unassigned 3,0 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28377410&form=6&db=m Papers of note in Science Immunology2 (9). causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28951420&form=6&db=m Metabolic energy sensors as targets for designing host-directed therapies for tuberculosis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31029687&form=6&db=m Role of Sirt1 in innate immune mechanisms against Mycobacterium tuberculosis via the inhibition of TAK1 activation. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32462533&form=6&db=m The dominant model analysis of Sirt3 genetic variants is associated with susceptibility to tuberculosis in a Chinese Han population. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33007281&form=6&db=m Sirtuin inhibits M. tuberculosis -induced apoptosis in macrophage through glycogen synthase kinase-3?. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28840510&form=6&db=m Cypermethrin Activates Autophagosome Formation Albeit Inhibits Autophagy Owing to Poor Lysosome Quality: Relevance to Parkinson's Disease. ongoing research,therapeutic application,unassigned 2,3,0 2.3.1.286 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31832445&form=6&db=m SIRT1 Gene Polymorphisms Are Associated with Urinary Bladder Cancer in an Iranian Population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 2.3.1.286 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33576215&form=6&db=m Selective Cytotoxicity of Kaempferia parviflora Extracts in Human Cell Lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.3.1.286 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25794641&form=6&db=m Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 2.3.1.286 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28797320&form=6&db=m Decreased Expression of MiR-138-5p by LncRNA H19 in Cervical Cancer Promotes Tumor Proliferation. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 2.3.1.286 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29844574&form=6&db=m Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.3.1.286 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31677030&form=6&db=m SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3 2.3.1.286 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31692593&form=6&db=m MiR-29a function as tumor suppressor in cervical cancer by targeting SIRT1 and predict patient prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 2.3.1.286 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31762241&form=6&db=m [Expression Level of SIRT2 in Cervical Cancer Tissue and Its Clinical Significance]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3 2.3.1.286 Vascular Calcification http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21037384&form=6&db=m [Regulatory Mechanisms and Practical Management in Vascular Calcification. Molecular Mechanism of Vascular Aging : Impact of Vascular Smooth Muscle Cell Calcification via Cellular Senescence.] causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Vascular Calcification http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33790547&form=6&db=m Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20044906&form=6&db=m SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.3.1.286 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23499302&form=6&db=m Cross-talk between SIRT1 and p66Shc in vascular diseases. causal interaction,unassigned 3,0 2.3.1.286 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27482292&form=6&db=m A Label-free Sirtuin 1 Assay based on Droplet-Electrospray Ionization Mass Spectrometry. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.286 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33790547&form=6&db=m Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.3.1.286 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22185448&form=6&db=m Targeting cardiovascular disease with novel SIRT1 pathways. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30622668&form=6&db=m Protective Role of Endogenous Kallistatin in Vascular Injury and Senescence by Inhibiting Oxidative Stress and Inflammation. causal interaction,unassigned 3,0 2.3.1.286 Venous Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31141719&form=6&db=m Danhong Huayu Koufuye prevents venous thrombosis through antiinflammation via Sirtuin 1/NF-?B signaling pathway. ongoing research,unassigned 3,0 2.3.1.286 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28025857&form=6&db=m Use of the Monte Carlo Method for OECD Principles-Guided QSAR Modeling of SIRT1 Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34149631&form=6&db=m Transcriptome Profiling Reveals a Novel Mechanism of Antiviral Immunity Upon Sacbrood Virus Infection in Honey Bee Larvae (Apis cerana). causal interaction,unassigned 3,0 2.3.1.286 Vitamin D Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31777705&form=6&db=m Effect of vitamin D supplementation in combination with weight loss diet on lipid profile and sirtuin 1 in obese subjects with vitamin D deficiency: a double blind randomized clinical trial. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.286 Vitiligo http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24410795&form=6&db=m SIRT1 regulates MAPK pathways in vitiligo skin: insight into the molecular pathways of cell survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 2.3.1.286 Vitiligo http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28753523&form=6&db=m Development and in vitro assessment of psoralen and resveratrol co-loaded ultradeformable liposomes for the treatment of vitiligo. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.286 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25085245&form=6&db=m The SIRT1/HIF2? axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy. therapeutic application,unassigned 4,0 2.3.1.286 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25342474&form=6&db=m Association between the SIRT1 mRNA Expression and Acute Coronary Syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24896770&form=6&db=m Sirt1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26219468&form=6&db=m Sirtuin 3 in acute kidney injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,2 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27362524&form=6&db=m Mitochondrial Sirtuin 3 and Renal Diseases. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28424621&form=6&db=m Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney Injury. causal interaction,unassigned 4,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29651144&form=6&db=m Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30379096&form=6&db=m SIRT1-mediated HMGB1 deacetylation suppresses sepsis-associated acute kidney injury. ongoing research,unassigned 4,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30445987&form=6&db=m Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30502252&form=6&db=m SIRT3 Inactivation Promotes Acute Kidney Injury Through Elevated Acetylation of SOD2 and p53. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31431003&form=6&db=m Pharmacological Activation of Sirt1 Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing Apoptosis, Oxidative Stress, and Inflammation in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32092826&form=6&db=m Activation of sirtuin1 protects against ischemia/reperfusion-induced acute kidney injury. ongoing research,unassigned 4,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32240312&form=6&db=m SIRT2 is involved in cisplatin-induced acute kidney injury through regulation of mitogen-activated protein kinase phosphatase-1. causal interaction,unassigned 4,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32281286&form=6&db=m Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice. causal interaction,unassigned 4,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33388853&form=6&db=m Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.286 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34249270&form=6&db=m Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28952835&form=6&db=m The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29363727&form=6&db=m Protective effect of SIRT3 on acute lung injury by increasing manganese superoxide dismutase-mediated antioxidation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29859833&form=6&db=m Metformin alleviated endotoxemia-induced acute lung injury via restoring AMPK-dependent suppression of mTOR. ongoing research,unassigned 4,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30528955&form=6&db=m Arbutin attenuates LPS-induced lung injury via Sirt1/ Nrf2/ NF-?Bp65 pathway. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30626741&form=6&db=m SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17638871&form=6&db=m SIRT1 is significantly elevated in mouse and human prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19433578&form=6&db=m SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22640743&form=6&db=m SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of ?-catenin. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23702379&form=6&db=m Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24816737&form=6&db=m Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25798752&form=6&db=m SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25915617&form=6&db=m Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26834854&form=6&db=m Association of SIRT1 and HMGA1 expression in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30945643&form=6&db=m Upregulation of SIRT1 gene in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32267139&form=6&db=m Hsa-miR-217 Inhibits the Proliferation, Migration, and Invasion in Non-small Cell Lung Cancer Cells Via Targeting SIRT1 and P53/KAI1 Signaling causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 2.3.1.286 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23842789&form=6&db=m Sirt3 is a tumor suppressor in lung adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24959282&form=6&db=m Sirt1 is a tumor promoter in lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25995644&form=6&db=m SIRT1 expression is associated with poor prognosis of lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31765940&form=6&db=m Targeting histone deacetylase SIRT1 selectively eradicates EGFR TKI-resistant cancer stem cells via regulation of mitochondrial oxidative phosphorylation in lung adenocarcinoma. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.286 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31932479&form=6&db=m E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19433578&form=6&db=m SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24816737&form=6&db=m Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30059665&form=6&db=m Modulating SIRT1 activity variously affects thymic lymphoma development in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Adrenoleukodystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25822341&form=6&db=m Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4 2.3.1.286 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28615249&form=6&db=m Reduction in podocyte SIRT1 accelerates kidney injury in aging mice. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30641941&form=6&db=m SIRT1 Attenuates Kidney Disorders in Male Offspring Due to Maternal High-Fat Diet. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32439965&form=6&db=m Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32887498&form=6&db=m Decreased Urinary Levels of SIRT1 as Non-Invasive Biomarker of Early Renal Damage in Hypertension. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17397914&form=6&db=m SIRT1 and neuronal diseases. causal interaction,unassigned 4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17637936&form=6&db=m Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17937892&form=6&db=m [SIRT1/PGC-1: a neuroprotective axis?] causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18438697&form=6&db=m Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease. diagnostic usage,ongoing research,unassigned 4,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19650880&form=6&db=m Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway. causal interaction,unassigned 4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19945548&form=6&db=m The role of Sirt1: At the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21121893&form=6&db=m SIRT1 deacetylase activity and the maintenance of protein homeostasis in response to stress: an overview. causal interaction,unassigned 4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21349442&form=6&db=m The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22121876&form=6&db=m Small-molecule chromatin-modifying agents: therapeutic applications. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22233091&form=6&db=m SIRT1: new avenues of discovery for disorders of oxidative stress. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22553202&form=6&db=m Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22953035&form=6&db=m Potential of chromatin modifying compounds for the treatment of Alzheimer's disease. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23139766&form=6&db=m CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23251824&form=6&db=m The Effects of SIRT1 on Alzheimer's Disease Models. ongoing research,unassigned 4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23689277&form=6&db=m Sirtuin deacetylases in neurodegenerative diseases of aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23712749&form=6&db=m Association between Sirtuin 2 gene rs10410544 polymorphism and depression in Alzheimer's disease in two independent European samples. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26819971&form=6&db=m Sirt1 in cerebral ischemia. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27333745&form=6&db=m [SIRT1]. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27423864&form=6&db=m Synthesis and Assay of SIRT1-Activating Compounds. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27497424&form=6&db=m SIRT1 as a therapeutic target for Alzheimer's disease. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27686535&form=6&db=m Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28086917&form=6&db=m Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28449871&form=6&db=m SIRT3 and mitochondrial metabolism in neurodegenerative diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28578695&form=6&db=m SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease. causal interaction,diagnostic usage,unassigned 4,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29130578&form=6&db=m SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease. causal interaction,unassigned 4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29226865&form=6&db=m SIRT1 Deacetylates SC35 and Suppresses Its Function in Tau Exon 10 Inclusion. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29574628&form=6&db=m Amyloid-? Increases Tau by Mediating Sirtuin 3 in Alzheimer's Disease. causal interaction,unassigned 4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29959974&form=6&db=m Neuroprotection by ethanolic extract of Syzygium aromaticum in Alzheimer's disease like pathology via maintaining oxidative balance through SIRT1 pathway. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30007474&form=6&db=m Sirtuin 1 and Alzheimer's disease: An up-to-date review. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30243024&form=6&db=m Sirt1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32038127&form=6&db=m Neuroprotective Effect of Resveratrol via Activation of Sirt1 Signaling in a Rat Model of Combined Diabetes and Alzheimer's Disease. ongoing research,unassigned 4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32747616&form=6&db=m Sirtuin 3 mRNA Expression is Downregulated in the Brain Tissues of Alzheimer's Disease Patients: A Bioinformatic and Data Mining Approach. causal interaction,unassigned 4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33597872&form=6&db=m SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33877561&form=6&db=m Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33998544&form=6&db=m The Protective Mechanism of SIRT1 in the Regulation of Mitochondrial Biogenesis and Mitochondrial Autophagy in Alzheimer's Disease. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34151764&form=6&db=m Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34393764&form=6&db=m Effects of Lipotoxicity in Brain Microvascular Endothelial Cells During Sirt3 Deficiency-Potential Role in Comorbid Alzheimer's Disease. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22137654&form=6&db=m Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1(G93A) transgenic mice as an in vivo model of amyotrophic lateral sclerosis. ongoing research,unassigned 4,0 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23000195&form=6&db=m Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice. ongoing research,unassigned 4,0 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23689277&form=6&db=m Sirtuin deacetylases in neurodegenerative diseases of aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27333745&form=6&db=m [SIRT1]. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27686535&form=6&db=m Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28449871&form=6&db=m SIRT3 and mitochondrial metabolism in neurodegenerative diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33877561&form=6&db=m Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34095262&form=6&db=m Sirt3 Protects Against Thoracic Aortic Dissection Formation by Reducing Reactive Oxygen Species, Vascular Inflammation, and Apoptosis of Smooth Muscle Cells. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Aneurysm, Dissecting http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34095262&form=6&db=m Sirt3 Protects Against Thoracic Aortic Dissection Formation by Reducing Reactive Oxygen Species, Vascular Inflammation, and Apoptosis of Smooth Muscle Cells. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Angiomyolipoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Arteritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34073102&form=6&db=m An Insight into Giant Cell Arteritis Pathogenesis: Evidence for Oxidative Stress and SIRT1 Downregulation. causal interaction,unassigned 4,0 2.3.1.286 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32320732&form=6&db=m SIRT1 Regulation in Ageing and Obesity. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29179491&form=6&db=m SIRT1 promotes tumor-like invasion of fibroblast-like synoviocytes in rheumatoid arthritis via targeting TIMP1. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30600470&form=6&db=m Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21742641&form=6&db=m SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23876775&form=6&db=m The class III histone deacetylase sirtuin 1 in immune suppression and its therapeutic potential in rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25799392&form=6&db=m Dysregulated serum IL-23 and SIRT1 activity in peripheral blood mononuclear cells of patients with rheumatoid arthritis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28193684&form=6&db=m An Agonist of the Protective Factor SIRT1 Improves Functional Recovery and Promotes Neuronal Survival by Attenuating Inflammation after Spinal Cord Injury. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28849139&form=6&db=m A study of Sirt1 regulation and the effect of resveratrol on synoviocyte invasion and associated joint destruction in rheumatoid arthritis. ongoing research,unassigned 4,0 2.3.1.286 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29179491&form=6&db=m SIRT1 promotes tumor-like invasion of fibroblast-like synoviocytes in rheumatoid arthritis via targeting TIMP1. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22964624&form=6&db=m Histone deacetylase inhibitors: can we consider potent anti-neoplastic agents for the treatment of asthma? causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26040995&form=6&db=m Increases in peripheral SIRT1: a new biological characteristic of asthma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29055943&form=6&db=m Suppression of Sirtuin-1 Increases IL-6 Expression by Activation of the Akt Pathway During Allergic Asthma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.3.1.286 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29843083&form=6&db=m SIRT7 regulates the TGF-?1-induced proliferation and migration of mouse airway smooth muscle cells by modulating the expression of TGF-? receptor I. causal interaction,unassigned 4,0 2.3.1.286 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30654657&form=6&db=m miR-221 participates in the airway epithelial cells injury in asthma via targeting SIRT1. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.3.1.286 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31542484&form=6&db=m Sirtuins as novel targets in the pathogenesis of airway inflammation in bronchial asthma. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32615160&form=6&db=m Bergenin-activated SIRT1 inhibits TNF-?-induced proinflammatory response by blocking the NF-?B signaling pathway. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32823491&form=6&db=m Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34099590&form=6&db=m Myeloid-specific SIRT1 deletion exacerbates airway inflammatory response in a mouse model of allergic asthma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23898190&form=6&db=m SIRT2 directs the replication stress response through CDK9 deacetylation. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17936707&form=6&db=m SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR. causal interaction,unassigned 4,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18689793&form=6&db=m Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19562740&form=6&db=m SIRT1: a novel target to prevent atherosclerosis. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20068143&form=6&db=m Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20215708&form=6&db=m SIRT1/eNOS Axis as a Potential Target against Vascular Senescence, Dysfunction and Atherosclerosis. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21810449&form=6&db=m Roles of SIRT1 in High Glucose-induced Endothelial Impairment: Association with Diabetic Atherosclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22233091&form=6&db=m SIRT1: new avenues of discovery for disorders of oxidative stress. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23259556&form=6&db=m SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23382833&form=6&db=m Peripheral blood monocyte Sirt1 expression is reduced in patients with coronary artery disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23652462&form=6&db=m SIRT1 prevents atherosclerosis via liver?X?receptor and NF??B signaling in a U937 cell model. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23774840&form=6&db=m Potential Mechanisms Linking Atherosclerosis and Increased Cardiovascular Risk in COPD: Focus On Sirtuins. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23968571&form=6&db=m Loss-of-SIRT1 function during vascular ageing: Hyperphosphorylation mediated by cyclin-dependent kinase 5. causal interaction,unassigned 4,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24002940&form=6&db=m Poly(ADP-ribose) Polymerase 1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Implications. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24370889&form=6&db=m Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24378473&form=6&db=m Enhancement in efferocytosis of oxidized low-density lipoprotein-induced apoptotic RAW264.7 cells through Sirt1-mediated autophagy. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24624081&form=6&db=m Vestibular rehabilitation ameliorates chronic dizziness through the SIRT1 axis. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25706717&form=6&db=m A TagSNP in SIRT1 Gene Confers Susceptibility to Myocardial Infarction in a Chinese Han Population. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26883442&form=6&db=m Impaired SIRT1 promotes the migration of vascular smooth muscle cell-derived foam cells. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27123454&form=6&db=m In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions. causal interaction,diagnostic usage,unassigned 4,1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27744418&form=6&db=m The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30458637&form=6&db=m Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases. causal interaction,unassigned 4,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31023999&form=6&db=m SIRT1 inhibits monocyte adhesion to the vascular endothelium by suppressing Mac-1 expression on monocytes. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31105126&form=6&db=m Estrogen-SIRT1 Axis Plays a Pivotal Role in Protecting Arteries Against Menopause-Induced Senescence and Atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31291416&form=6&db=m Serum Sirtuin 1, 3 and 6 Levels in Acute Myocardial Infarction Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31432137&form=6&db=m MicroRNA?217 is involved in the progression of atherosclerosis through regulating inflammatory responses by targeting sirtuin 1. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31696493&form=6&db=m Correlation between endothelial cell apoptosis and SIRT3 gene expression in atherosclerosis rats. ongoing research,unassigned 4,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32320732&form=6&db=m SIRT1 Regulation in Ageing and Obesity. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33460661&form=6&db=m Suppression of microRNA-323-3p restrains vascular endothelial cell apoptosis via promoting sirtuin-1 expression in coronary heart disease. ongoing research,unassigned 4,0 2.3.1.286 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28043667&form=6&db=m A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19729833&form=6&db=m The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22105513&form=6&db=m Sirtuin 1 in immune regulation and autoimmunity. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23876775&form=6&db=m The class III histone deacetylase sirtuin 1 in immune suppression and its therapeutic potential in rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Blast Crisis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22340598&form=6&db=m Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 2.3.1.286 Bone Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28677728&form=6&db=m Overexpression of SIRT1 prevents hypoxia?induced apoptosis in osteoblast cells. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Bone Marrow Failure Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31178326&form=6&db=m The Sirt1 activator resveratrol improved hematopoiesis in pancytopenia mice induced by irradiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,2 2.3.1.286 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33878033&form=6&db=m Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Bowen's Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17180656&form=6&db=m Strong expression of a longevity-related protein, SIRT1, in Bowen's disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Bowen's Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33363940&form=6&db=m Overlapping tumor-specific expression of p53, p16INK4a, and sirtuin 1 in Bowen's disease: A case report. causal interaction,unassigned 4,0 2.3.1.286 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26094939&form=6&db=m Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20381504&form=6&db=m Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha Expression in experimental stroke. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.286 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29039533&form=6&db=m SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.3.1.286 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30336174&form=6&db=m SIRT1 activation by butein attenuates sepsis-induced brain injury in mice subjected to cecal ligation and puncture via alleviating inflammatory and oxidative stress. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32221271&form=6&db=m Treatment of Brain Edema by Wogonoside Is Associated with Inhibition of Neuronal Apoptosis and SIRT1 Activation in Rats. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32922930&form=6&db=m SIRT3 protects against early brain injury following subarachnoid hemorrhage via promoting mitochondrial fusion in an AMPK dependent manner. therapeutic application,unassigned 4,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20381504&form=6&db=m Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha Expression in experimental stroke. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25981395&form=6&db=m Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26094939&form=6&db=m Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26639783&form=6&db=m Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27350577&form=6&db=m SIRT2 Plays Significant Roles in Lipopolysaccharides-Induced Neuroinflammation and Brain Injury in Mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27735947&form=6&db=m Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28527875&form=6&db=m Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30048156&form=6&db=m Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll-like receptor 4 signaling pathway. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30336174&form=6&db=m SIRT1 activation by butein attenuates sepsis-induced brain injury in mice subjected to cecal ligation and puncture via alleviating inflammatory and oxidative stress. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31651707&form=6&db=m The small RNA microRNA-212 regulates sirtuin 2 expression in a cellular model of oxygen-glucose deprivation. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32203080&form=6&db=m Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32922930&form=6&db=m SIRT3 protects against early brain injury following subarachnoid hemorrhage via promoting mitochondrial fusion in an AMPK dependent manner. therapeutic application,unassigned 4,0 2.3.1.286 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32923413&form=6&db=m Sirt1 Regulates Oxidative Stress in Oxygen-Glucose Deprived Hippocampal Neurons. ongoing research,unassigned 4,0 2.3.1.286 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014276&form=6&db=m The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33063734&form=6&db=m Batroxobin inhibits astrocyte activation following nigrostriatal pathway injury. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18537630&form=6&db=m Resveratrol and ischemic preconditioning in the brain. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19356683&form=6&db=m Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24323420&form=6&db=m SIRT1 regulation modulates stroke outcome. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25433241&form=6&db=m SIRT3 protects cells from hypoxia via PGC-1?- and MnSOD-dependent pathways. ongoing research,unassigned 4,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25981395&form=6&db=m Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26219598&form=6&db=m Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26622348&form=6&db=m Resveratrol relieves ischemia-induced oxidative stress in the hippocampus by activating SIRT1. ongoing research,unassigned 4,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26819971&form=6&db=m Sirt1 in cerebral ischemia. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28527875&form=6&db=m Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28937253&form=6&db=m Sirt1 mediates improvement in cognitive defects induced by focal cerebral ischemia following hyperbaric oxygen preconditioning in rats. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29039533&form=6&db=m SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31651707&form=6&db=m The small RNA microRNA-212 regulates sirtuin 2 expression in a cellular model of oxygen-glucose deprivation. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32203080&form=6&db=m Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014276&form=6&db=m The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33665656&form=6&db=m [Acute cerebral ischemia-induced down-regulation of Sirt3 protein expression contributes to neuronal injury via damaging mitochondrial function]. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16211212&form=6&db=m FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene, Sirtuin 2 (Sirt2). causal interaction,unassigned 4,0 2.3.1.286 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29039533&form=6&db=m SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.3.1.286 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29991742&form=6&db=m A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.3.1.286 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32158616&form=6&db=m SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3? activity in neuroblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16170353&form=6&db=m Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. ongoing research,unassigned 4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17003781&form=6&db=m Altered sirtuin expression is associated with node-positive breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18850005&form=6&db=m Deacetylation of cortactin by SIRT1 promotes cell migration. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19509139&form=6&db=m Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20412117&form=6&db=m Balance between SIRT1 and DBC1 expression is lost in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20713551&form=6&db=m Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1. causal interaction,unassigned 4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21056897&form=6&db=m Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21397863&form=6&db=m SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1? Destabilization. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21596753&form=6&db=m miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21920899&form=6&db=m SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor ? in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22470132&form=6&db=m SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22553202&form=6&db=m Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22661383&form=6&db=m Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22977628&form=6&db=m Expression of DBC1 is associated with nuclear grade and HER2 expression in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23340254&form=6&db=m SIRT1 Positively Regulates Breast Cancer Associated Human Aromatase (CYP19A1) Expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23562596&form=6&db=m Identification of novel SIRT3 inhibitor scaffolds by virtual screening. causal interaction,unassigned 4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23673452&form=6&db=m SIRT1 suppresses breast cancer growth through downregulation of the Bcl-2 protein. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23842789&form=6&db=m Sirt3 is a tumor suppressor in lung adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23856293&form=6&db=m Identification of Sirtuin 3, a mitochondrial protein deacetylase, as a new contributor to tamoxifen resistance in breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24009628&form=6&db=m SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24278473&form=6&db=m SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24746213&form=6&db=m Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24955214&form=6&db=m SOD1, an unexpected novel target for cancer therapy. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24959376&form=6&db=m Histone/protein deacetylase SIRT1 is an anticancer therapeutic target. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25420528&form=6&db=m Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25732823&form=6&db=m DBC1 Functions as a Tumor Suppressor by Regulating p53 Stability. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25785036&form=6&db=m Clinicopathological and prognostic role of SIRT1 in breast cancer patients: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25922576&form=6&db=m Altered Sirtuin 7 Expression is Associated with Early Stage Breast Cancer. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26004371&form=6&db=m Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26141949&form=6&db=m CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26225773&form=6&db=m SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26280894&form=6&db=m Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26515337&form=6&db=m SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26585892&form=6&db=m Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26902145&form=6&db=m BRCA1 inhibits AR-mediated proliferation of breast cancer cells through the activation of SIRT1. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26935174&form=6&db=m MnSOD acetylation and dys-regulation, due to loss of SIRT3 activity, promotes a Luminal B-like breast carcinogenic permissive phenotype. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26999517&form=6&db=m Association between SIRT1 Gene Polymorphisms and Breast Cancer in Egyptians. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27080717&form=6&db=m High-throughput screening of Sirtuin family of genes in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27186285&form=6&db=m Effect of the BRCA1-SIRT1-EGFR axis on cisplatin sensitivity in ovarian cancer. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27277416&form=6&db=m Expression of FOXM1 and related proteins in breast cancer molecular subtypes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27358235&form=6&db=m Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27420645&form=6&db=m SIRT3 Silencing Sensitizes Breast Cancer Cells to Cytotoxic Treatments Through an Increment in ROS Production. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27483432&form=6&db=m The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27698834&form=6&db=m Decreased sirtuin 4 expression is associated with poor prognosis in patients with invasive breast cancer. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27725455&form=6&db=m Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27782173&form=6&db=m Mesenchymal stem cells with Sirt1 overexpression suppress breast tumor growth via chemokine-dependent natural killer cells recruitment. ongoing research,unassigned 4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28235484&form=6&db=m Branched-chain amino acid transaminase 1 (BCAT1) promotes the growth of breast cancer cells through improving mTOR-mediated mitochondrial biogenesis and function. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28560068&form=6&db=m HDAC2 overexpression correlates with aggressive clinicopathological features and DNA-damage response pathway of breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28882183&form=6&db=m miR-22 suppresses tumorigenesis and improves radiosensitivity of breast cancer cells by targeting Sirt1. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29340027&form=6&db=m Dual SIRT1 expression patterns strongly suggests its bivalent role in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29653746&form=6&db=m SRT1720, a potential sensitizer for radiotherapy and cytotoxicity effects of NVB-BEZ235 in metastatic breast cancer cells. ongoing research,therapeutic application,unassigned 1,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29695913&form=6&db=m Combination of SIRT1 and Src overexpression suggests poor prognosis in luminal breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29752439&form=6&db=m A novel long non-coding RNA-PRLB acts as a tumor promoter through regulating miR-4766-5p/SIRT1 axis in breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29807012&form=6&db=m SIRT1 promotes proliferation, migration, and invasion of breast cancer cell line MCF-7 by upregulating DNA polymerase delta1 (POLD1). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,2 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29896286&form=6&db=m SIRT1 promotes formation of breast cancer through modulating Akt activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29915029&form=6&db=m Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30258927&form=6&db=m Effect of Sirtuin 1 inhibition on matrix metalloproteinase 2 and Forkhead box O3a expression in breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30319540&form=6&db=m SIRT1 and Estrogen Signaling Cooperation for Breast Cancer Onset and Progression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30380732&form=6&db=m Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30520099&form=6&db=m MicroRNA-590-3P suppresses cell survival and triggers breast cancer cell apoptosis via targeting sirtuin-1 and deacetylation of p53. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30620711&form=6&db=m The effect of adipocyte-macrophage cross-talk in obesity-related breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30826489&form=6&db=m The Contrary Effects of Sirt1 on MCF7 Cells Depend on CD36 Expression Level. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31101119&form=6&db=m Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31220581&form=6&db=m Inhibition of sirtuin 1 deacetylase by miR-211-5p provides a mechanism for the induction of cell death in breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31341634&form=6&db=m A novel Ubc9 -dependent pathway regulates SIRT1- ER-? Axis and BRCA1-associated TNBC lung metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31404596&form=6&db=m Structure-based identification of novel sirtuin inhibitors against triple negative breast cancer: An in silico and in vitro study. therapeutic application,unassigned 4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31781916&form=6&db=m The beneficial role of SIRT1 activator on chemo- and radiosensitization of breast cancer cells in response to IL-6. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32271700&form=6&db=m Lemon Juice as a Biocatalyst Under Ultrasound Irradiation: Synthesis and Pharmacological Evaluation of 2-amino 1,3,4-thiadiazoles. ongoing research,therapeutic application,unassigned 2,4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32538772&form=6&db=m Construction of SIRT1 gene shRNA lentivirus vector and its effect on the proliferation of breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32863939&form=6&db=m Loss of SIRT4 promotes the self-renewal of Breast Cancer Stem Cells. causal interaction,unassigned 4,0 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33061819&form=6&db=m The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33231084&form=6&db=m PGC-1? activates SIRT3 to modulate cell proliferation and glycolytic metabolism in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.3.1.286 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33705642&form=6&db=m The study of sirtuins in breast cancer patients before and after radiotherapy causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Bulbo-Spinal Atrophy, X-Linked http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23689277&form=6&db=m Sirtuin deacetylases in neurodegenerative diseases of aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Candidiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28894448&form=6&db=m Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16546327&form=6&db=m SIRT1: tumor promoter or tumor suppressor? causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17180656&form=6&db=m Strong expression of a longevity-related protein, SIRT1, in Bowen's disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17638871&form=6&db=m SIRT1 is significantly elevated in mouse and human prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18835033&form=6&db=m Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18850005&form=6&db=m Deacetylation of cortactin by SIRT1 promotes cell migration. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18851829&form=6&db=m Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19060927&form=6&db=m Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19173036&form=6&db=m SIRT1, is it a tumor promoter or tumor suppressor? causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19260974&form=6&db=m Silent information regulator, Sirtuin 1, and age-related diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19404850&form=6&db=m Expression and prognostic significance of SIRT1 in ovarian epithelial tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20412117&form=6&db=m Balance between SIRT1 and DBC1 expression is lost in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20471503&form=6&db=m SIRT1 and p53, effect on cancer, senescence and beyond. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20956937&form=6&db=m NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21414717&form=6&db=m Sirtuin 1 in malignant transformation: Friend or foe? causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21677689&form=6&db=m SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22014574&form=6&db=m SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22016654&form=6&db=m Sirt3, Mitochondrial ROS, Ageing, and Carcinogenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22105513&form=6&db=m Sirtuin 1 in immune regulation and autoimmunity. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22146883&form=6&db=m SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22149272&form=6&db=m SIRT1 and the clock gene machinery in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22180829&form=6&db=m The role of SIRT1 in tumorigenesis. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22233091&form=6&db=m SIRT1: new avenues of discovery for disorders of oxidative stress. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22552445&form=6&db=m SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22730114&form=6&db=m Sirtuin activators and inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22943040&form=6&db=m SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22977628&form=6&db=m Expression of DBC1 is associated with nuclear grade and HER2 expression in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22986535&form=6&db=m SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23016857&form=6&db=m Rejuvenating sirtuins: the rise of a new family of cancer drug targets. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23024800&form=6&db=m SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23255128&form=6&db=m Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23370328&form=6&db=m Sirtuin-1 Regulates Acinar-to-Ductal Metaplasia and Supports Cancer Cell Viability in Pancreatic Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23799088&form=6&db=m Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23805287&form=6&db=m The Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23843607&form=6&db=m PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23859614&form=6&db=m A Dual Role for Sirtuin 1 in Tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23915912&form=6&db=m Regulation of SIRT2 levels for human non-small cell lung cancer therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24020000&form=6&db=m The Roles of SIRT1 in Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24020004&form=6&db=m SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24035280&form=6&db=m Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24223900&form=6&db=m SIRT1 expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24278473&form=6&db=m SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24338587&form=6&db=m SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24386506&form=6&db=m Nicotinamide Phosphoribosyltransferase in Malignancy: A Review. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24416313&form=6&db=m Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24959282&form=6&db=m Sirt1 is a tumor promoter in lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25131770&form=6&db=m SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25270091&form=6&db=m SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25349202&form=6&db=m SIRT2 Regulates LPS-Induced Renal Tubular CXCL2 and CCL2 Expression. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25469273&form=6&db=m Sirtuin1 expression predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25485577&form=6&db=m A novel role of SIRT1 in gammaherpesvirus latency and replication. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25500546&form=6&db=m High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25569080&form=6&db=m Diverse roles of SIRT1 in cancer biology and lipid metabolism. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25798752&form=6&db=m SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25843411&form=6&db=m SIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25926383&form=6&db=m Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26121130&form=6&db=m SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26318035&form=6&db=m SIRT1 in B[a]P-induced lung tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26657080&form=6&db=m The Proteomic Profile of Deleted in Breast Cancer 1 (DBC1) Interactions Points to a Multifaceted Regulation of Gene Expression. therapeutic application,unassigned 4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26743598&form=6&db=m Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26959057&form=6&db=m Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27746184&form=6&db=m CK2?/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27793039&form=6&db=m SIRT1 promotes metastasis of human osteosarcoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27840909&form=6&db=m Sirtuin 3: A Janus face in cancer (Review). causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28287409&form=6&db=m Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28351313&form=6&db=m SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28461331&form=6&db=m Sirtuin 2 mutations in human cancers impair its function in genome maintenance. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28514749&form=6&db=m A variant in SIRT2 gene 3'-UTR is associated with susceptibility to colorectal cancer. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28882183&form=6&db=m miR-22 suppresses tumorigenesis and improves radiosensitivity of breast cancer cells by targeting Sirt1. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28935184&form=6&db=m Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29194618&form=6&db=m Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial-mesenchymal transition in cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29340027&form=6&db=m Dual SIRT1 expression patterns strongly suggests its bivalent role in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29650970&form=6&db=m Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29685974&form=6&db=m Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29807012&form=6&db=m SIRT1 promotes proliferation, migration, and invasion of breast cancer cell line MCF-7 by upregulating DNA polymerase delta1 (POLD1). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,2 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29966233&form=6&db=m A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30058691&form=6&db=m Expression of SIRT1 gene in human lung cancer lines enhances their sensitivity to the anticancer effects of cisplatin. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30059665&form=6&db=m Modulating SIRT1 activity variously affects thymic lymphoma development in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30081901&form=6&db=m Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30095923&form=6&db=m SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30333863&form=6&db=m Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30367038&form=6&db=m Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30380732&form=6&db=m Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30410074&form=6&db=m Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30484407&form=6&db=m Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer's Disease. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30584257&form=6&db=m Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30715550&form=6&db=m Constitutive Activation of NAD-Dependent Sirtuin 3 Plays an Important Role in Tumorigenesis of Chromium(VI)-Transformed Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31186751&form=6&db=m Sirtuin 1 knockdown inhibits glioma cell proliferation and potentiates temozolomide toxicity via facilitation of reactive oxygen species generation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31282985&form=6&db=m Research progress on SIRT1 and sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31576168&form=6&db=m A New Regulatory Mechanism Between P53 And YAP Crosstalk By SIRT1 Mediated Deacetylation To Regulate Cell Cycle And Apoptosis In A549 Cell Lines. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31931863&form=6&db=m DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing-a possible predictive biomarker for malignant transformation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,2 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31932479&form=6&db=m E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32098999&form=6&db=m Investigation of sirtuin 1 polymorphisms in relation to the risk of colorectal cancer by molecular subtype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32361710&form=6&db=m Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32426286&form=6&db=m Sirtuin 1 Inhibiting Thiocyanates (S1th)-A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32449165&form=6&db=m The role of SIRT2 in cancer: A novel therapeutic target. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32714081&form=6&db=m HBx mediated Increase of SIRT1 Contributes to HBV-related Hepatocellular Carcinoma Tumorigenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014852&form=6&db=m The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene? causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33061819&form=6&db=m The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33276056&form=6&db=m Targeting Sirtuin 1 signaling pathway by ginsenosides. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33401967&form=6&db=m miR-124-3p combined with miR-506-3p delay hepatic carcinogenesis via modulating sirtuin 1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33649834&form=6&db=m SIRT1 and gynecological malignancies (Review). causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33937086&form=6&db=m Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34163012&form=6&db=m SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34235106&form=6&db=m Inhibition of SIRT1 Limits Self-Renewal and Oncogenesis by Inducing Senescence of Liver Cancer Stem Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17180656&form=6&db=m Strong expression of a longevity-related protein, SIRT1, in Bowen's disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19404850&form=6&db=m Expression and prognostic significance of SIRT1 in ovarian epithelial tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19433578&form=6&db=m SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19509139&form=6&db=m Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19725468&form=6&db=m Role of prosurvival molecules in the action of lidamycin toward human tumor cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23453030&form=6&db=m SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23562596&form=6&db=m Identification of novel SIRT3 inhibitor scaffolds by virtual screening. causal interaction,unassigned 4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23805287&form=6&db=m The Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23881456&form=6&db=m Growth Inhibition and Apoptosis-Inducing Effects of Cudraflavone B in Human Oral Cancer Cells via MAPK, NF-?B, and SIRT1 Signaling Pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23898059&form=6&db=m Nicotinamide phosphoribosyltransferase and SIRT3 expression are increased in well-differentiated thyroid carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23898224&form=6&db=m Inhibition of SIRT1 combined with gemcitabine therapy for pancreatic carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24018803&form=6&db=m Acetylation status of P53 and the expression of DBC1, SIRT1, and androgen receptor are associated with survival in clear cell renal cell carcinoma patients. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24287180&form=6&db=m Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25696003&form=6&db=m Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25915617&form=6&db=m Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25946975&form=6&db=m Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26299580&form=6&db=m Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26317998&form=6&db=m SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26662958&form=6&db=m Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26862948&form=6&db=m Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26893713&form=6&db=m Expression and clinical significance of Sirt1 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27216459&form=6&db=m Down-regulation of SIRT3 promotes ovarian carcinoma metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,3 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28197634&form=6&db=m SIRT3 is correlated with the malignancy of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28526414&form=6&db=m A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28667895&form=6&db=m SIRT1 Regulates the Chemoresistance and Invasiveness of Ovarian Carcinoma Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28867266&form=6&db=m Low SIRT3 expression contributes to tumor progression, development and poor prognosis in human pancreatic carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28935184&form=6&db=m Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29029516&form=6&db=m The prognostic role of Sirt1 expression in solid malignancies: a meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29050728&form=6&db=m SIRT1 acts as a potential tumor suppressor in oral squamous cell carcinoma. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29194618&form=6&db=m Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial-mesenchymal transition in cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29636061&form=6&db=m SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29739048&form=6&db=m Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30095923&form=6&db=m SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30261494&form=6&db=m Role of SIRT2 in Regulation of Stemness of Cancer Stem-Like Cells in Renal Cell Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30518708&form=6&db=m SIRT1 knockdown up-regulates p53 and p21/Cip1 expression in renal adenocarcinoma cells but not in normal renal-derived cells in a deacetylase-independent manner. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31055111&form=6&db=m MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31219487&form=6&db=m Overexpression of SIRT1 in urothelial carcinoma of the urinary bladder is associated with local recurrence and poor survival. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31317367&form=6&db=m Cytoplasmic SIRT1 inhibits cell migration and invasion by impeding epithelial-mesenchymal transition in ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31684999&form=6&db=m ADC correlation with Sirtuin1 to assess early chemoradiotherapy response of locally advanced esophageal carcinoma patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31931863&form=6&db=m DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing-a possible predictive biomarker for malignant transformation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,2 2.3.1.286 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32878301&form=6&db=m Synergistic Effect of Dietary Betaines on SIRT1-Mediated Apoptosis in Human Oral Squamous Cell Carcinoma Cal 27. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17180656&form=6&db=m Strong expression of a longevity-related protein, SIRT1, in Bowen's disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23340254&form=6&db=m SIRT1 Positively Regulates Breast Cancer Associated Human Aromatase (CYP19A1) Expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26004371&form=6&db=m Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26280894&form=6&db=m Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18239056&form=6&db=m Involvement of mammalian sirtuin 1 in the action of ethanol in the liver. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21567102&form=6&db=m Expression and role of SIRT1 in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22146883&form=6&db=m SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22302044&form=6&db=m SirT1 confers hypoxia-induced radioresistance via the modulation of c-Myc stabilization on hepatoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22552445&form=6&db=m SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23024800&form=6&db=m SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23137540&form=6&db=m SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23339189&form=6&db=m Antitumor Effect of SIRT1 Inhibition in Human HCC Tumor Models In Vitro and In Vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23348706&form=6&db=m SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition via akt/GSK-3?/?-catenin signaling (revised version). causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23790338&form=6&db=m SIRT3 expression in hepatocellular carcinoma and its impact on proliferation and invasion of hepatoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23842789&form=6&db=m Sirt3 is a tumor suppressor in lung adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24338587&form=6&db=m SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24416313&form=6&db=m Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25131770&form=6&db=m SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25522783&form=6&db=m Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25696003&form=6&db=m Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25915842&form=6&db=m Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3?/BCL2-associated X protein-dependent apoptotic pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27081083&form=6&db=m SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1?-mediated mitochondrial biogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27367026&form=6&db=m Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27390038&form=6&db=m Fusaric acid induces mitochondrial stress in human hepatocellular carcinoma (HepG2) cells. ongoing research,unassigned 4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27483432&form=6&db=m The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28983625&form=6&db=m Resveratrol inhibits proliferation and migration through SIRT1 mediated post?translational modification of PI3K/AKT signaling in hepatocellular carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29217762&form=6&db=m SIRT6 Is a Target of Regulation by UBE3A That Contributes to Liver Tumorigenesis in an ANXA2-Dependent Manner. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30111572&form=6&db=m Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis via the AKT/GSK-3?/?-Catenin Signaling Pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30955067&form=6&db=m Sirtuin2 enhances the tumoricidal function of liver natural killer cells in a mouse hepatocellular carcinoma model. ongoing research,unassigned 4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31076630&form=6&db=m miR-494 induces EndMT and promotes the development of HCC (Hepatocellular Carcinoma) by targeting SIRT3/TGF-?/SMAD signaling pathway. ongoing research,unassigned 4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31608282&form=6&db=m SIRT1 in the Development and Treatment of Hepatocellular Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32493816&form=6&db=m An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone Lysine Methyltransferases. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32562663&form=6&db=m Sirt3 promotes hepatocellular carcinoma cells sensitivity to regorafenib through the acceleration of mitochondrial dysfunction. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32607257&form=6&db=m Hepatocellular Expression of SIRT1 and Its Effect on Hepatocellular Carcinoma Progression: A Future Therapeutic Perspective. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32714081&form=6&db=m HBx mediated Increase of SIRT1 Contributes to HBV-related Hepatocellular Carcinoma Tumorigenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014852&form=6&db=m The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene? causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33931611&form=6&db=m Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34433910&form=6&db=m Sirt1 deficiency upregulates glutathione metabolism to prevent hepatocellular carcinoma initiation in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23702379&form=6&db=m Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23915912&form=6&db=m Regulation of SIRT2 levels for human non-small cell lung cancer therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24223900&form=6&db=m SIRT1 expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24228097&form=6&db=m SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration. causal interaction,unassigned 4,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25197348&form=6&db=m Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25719312&form=6&db=m SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2A. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25915617&form=6&db=m Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26834854&form=6&db=m Association of SIRT1 and HMGA1 expression in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26903157&form=6&db=m [SIRT1 Influences the Sensitivity of A549 Non-small Cell Lung Cancer Cell Line to ?Cisplatin via Modulating the Noxa Expression]. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26942878&form=6&db=m SIRT2 inhibits non-small cell lung cancer cell growth through impairing Skp2-mediated p27 degradation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27768839&form=6&db=m Diagnostic investigation of BIRC6 and SIRT1 protein expression level as potential prognostic biomarkers in patients with non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28073696&form=6&db=m SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28197634&form=6&db=m SIRT3 is correlated with the malignancy of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28498463&form=6&db=m miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29103158&form=6&db=m SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29535539&form=6&db=m SIRT1 overexpression protects non-small cell lung cancer cells against osteopontin-induced epithelial-mesenchymal transition by suppressing NF-?B signaling. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30067423&form=6&db=m Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31760527&form=6&db=m RBM38 induces SIRT1 expression during hypoxia in non-small cell lung cancer cells by suppressing MIR34A expression. ongoing research,unassigned 4,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32267139&form=6&db=m Hsa-miR-217 Inhibits the Proliferation, Migration, and Invasion in Non-small Cell Lung Cancer Cells Via Targeting SIRT1 and P53/KAI1 Signaling causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014852&form=6&db=m The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene? causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34405009&form=6&db=m Sirt3 Promoted DNA Damage Repair and Radioresistance Through ATM-Chk2 in Non-small Cell Lung Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34429771&form=6&db=m Emerging role of SIRT2 in non-small cell lung cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26520143&form=6&db=m Over-expression of Sirt1 contributes to chemoresistance and indicates poor prognosis in serous epithelial ovarian cancer (EOC). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28927063&form=6&db=m microRNA-494 is a potential prognostic marker and inhibits cellular proliferation, migration and invasion by targeting SIRT1 in epithelial ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24018803&form=6&db=m Acetylation status of P53 and the expression of DBC1, SIRT1, and androgen receptor are associated with survival in clear cell renal cell carcinoma patients. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.286 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28935184&form=6&db=m Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3 2.3.1.286 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30095923&form=6&db=m SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30261494&form=6&db=m Role of SIRT2 in Regulation of Stemness of Cancer Stem-Like Cells in Renal Cell Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30518708&form=6&db=m SIRT1 knockdown up-regulates p53 and p21/Cip1 expression in renal adenocarcinoma cells but not in normal renal-derived cells in a deacetylase-independent manner. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17180656&form=6&db=m Strong expression of a longevity-related protein, SIRT1, in Bowen's disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23453030&form=6&db=m SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23805287&form=6&db=m The Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 2.3.1.286 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25915617&form=6&db=m Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.3.1.286 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25946975&form=6&db=m Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26299580&form=6&db=m Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28197634&form=6&db=m SIRT3 is correlated with the malignancy of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32878301&form=6&db=m Synergistic Effect of Dietary Betaines on SIRT1-Mediated Apoptosis in Human Oral Squamous Cell Carcinoma Cal 27. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17446436&form=6&db=m Sirt1 regulates aging and resistance to oxidative stress in the heart. causal interaction,unassigned 4,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19142216&form=6&db=m Sirt1 hyperexpression in SHR heart related to left ventricular hypertrophy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21115502&form=6&db=m Sirt1 acts in association with PPAR{alpha} to protect the heart from hypertrophy, metabolic dysregulation, and inflammation. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22394676&form=6&db=m Friedreich's Ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase. causal interaction,unassigned 4,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26232232&form=6&db=m The role of sirtuins in cardiac disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28542596&form=6&db=m Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy. causal interaction,unassigned 4,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29643974&form=6&db=m SIRT3: A New Regulator of Cardiovascular Diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30132870&form=6&db=m Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30458637&form=6&db=m Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases. causal interaction,unassigned 4,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31291416&form=6&db=m Serum Sirtuin 1, 3 and 6 Levels in Acute Myocardial Infarction Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32140263&form=6&db=m SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32218740&form=6&db=m Sirtuin1 Role in the Melatonin Protective Effects Against Obesity-Related Heart Injury. causal interaction,unassigned 4,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32296036&form=6&db=m SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32931562&form=6&db=m Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014281&form=6&db=m LCZ696 Ameliorates Oxidative Stress and Pressure Overload-Induced Pathological Cardiac Remodeling by Regulating the Sirt3/MnSOD Pathway. causal interaction,unassigned 4,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33247214&form=6&db=m MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33388853&form=6&db=m Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33934090&form=6&db=m The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34028177&form=6&db=m The role of SIRT2 in vascular-related and heart-related diseases: A review. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17446436&form=6&db=m Sirt1 regulates aging and resistance to oxidative stress in the heart. causal interaction,unassigned 4,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19260974&form=6&db=m Silent information regulator, Sirtuin 1, and age-related diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22394676&form=6&db=m Friedreich's Ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase. causal interaction,unassigned 4,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22986367&form=6&db=m Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart. causal interaction,unassigned 4,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26109180&form=6&db=m The effects of resveratrol and SIRT1 activation on dystrophic cardiomyopathy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27764247&form=6&db=m SIRT1-PGC1?-NF?B Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31201798&form=6&db=m Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31393272&form=6&db=m SIRT1 Mediates Septic Cardiomyopathy in a Murine Model of Polymicrobial Sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32153406&form=6&db=m Perindopril Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1? in a Rat Model of Isoproterenol-Induced Cardiomyopathy. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32404204&form=6&db=m Autophagy-dependent and -independent modulation of oxidative and organellar stress in the diabetic heart by glucose-lowering drugs. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32486051&form=6&db=m SIRT1 Activation by Equisetum Arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33247214&form=6&db=m MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33537003&form=6&db=m Epigenetic Regulation Associated With Sirtuin 1 in Complications of Diabetes Mellitus. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21964378&form=6&db=m Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice. causal interaction,unassigned 4,0 2.3.1.286 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22986367&form=6&db=m Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart. causal interaction,unassigned 4,0 2.3.1.286 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31201798&form=6&db=m Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33138323&form=6&db=m TLR9 Binding to Beclin 1 and Mitochondrial SIRT3 by a Sodium-Glucose Co-Transporter 2 Inhibitor Protects the Heart from Doxorubicin Toxicity. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24211423&form=6&db=m Sesamin ameliorates doxorubicin-induced cardiotoxicity: involvement of Sirt1 and Mn-SOD pathway. causal interaction,unassigned 4,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25230823&form=6&db=m Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28423723&form=6&db=m Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33275987&form=6&db=m Cilostazol preconditioning alleviates cyclophosphamide-induced cardiotoxicity in male rats: Mechanistic insights into SIRT1 signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18641460&form=6&db=m Emerging roles of SIRT1 in vascular endothelial homeostasis. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19260974&form=6&db=m Silent information regulator, Sirtuin 1, and age-related diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19815564&form=6&db=m ACTIVATION OF SIRT1 BY RESVERATROL INDUCES KLF2 EXPRESSION CONFERRING AN ENDOTHELIAL VASOPROTECTIVE PHENOTYPE. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20601277&form=6&db=m Sirtuin activators: Designing molecules to extend life span. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22203920&form=6&db=m Translating cell survival and cell longevity into treatment strategies with SIRT1. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22233091&form=6&db=m SIRT1: new avenues of discovery for disorders of oxidative stress. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22796566&form=6&db=m Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23248098&form=6&db=m Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25582759&form=6&db=m Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: The role of sirtuin 1 gene variants in human coronary atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25665637&form=6&db=m The relationship of SIRT3 with cellular metabolism and cardiovascular diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26122034&form=6&db=m SIRT1 as a promising novel therapeutic target for myocardial ischemia reperfusion injury and cardiometabolic disease. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26232232&form=6&db=m The role of sirtuins in cardiac disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26477463&form=6&db=m Sirtuins: a possible clinical implication in cardio- and cerebro- vascular systems. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27128560&form=6&db=m Ablation of SIRT3 causes coronary microvascular dysfunction and impairs cardiac recovery post myocardial ischemia. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28811647&form=6&db=m Biogenesis of Pro-senescent Microparticles by Endothelial Colony Forming Cells from Premature Neonates is driven by SIRT1-Dependent Epigenetic Regulation of MKK6. causal interaction,unassigned 4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28963101&form=6&db=m Chronic Psychological Stress Accelerates Vascular Senescence and Impairs Ischemia-Induced Neovascularization: The Role of Dipeptidyl Peptidase-4/Glucagon-Like Peptide-1-Adiponectin Axis. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29446717&form=6&db=m Activators of Sirtuin-1 and their Involvement in Cardioprotection. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29643974&form=6&db=m SIRT3: A New Regulator of Cardiovascular Diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30132870&form=6&db=m Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30374331&form=6&db=m High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30458637&form=6&db=m Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases. causal interaction,unassigned 4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30510203&form=6&db=m SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain. causal interaction,unassigned 4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31852393&form=6&db=m Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32089765&form=6&db=m Resveratrol Prevents Right Ventricle Remodeling and Dysfunction in Monocrotaline-Induced Pulmonary Arterial Hypertension with a Limited Improvement in the Lung Vasculature. therapeutic application,unassigned 4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32486051&form=6&db=m SIRT1 Activation by Equisetum Arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33233553&form=6&db=m SIRT3 Deficiency Sensitizes Angiotensin-II-Induced Renal Fibrosis. causal interaction,unassigned 4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33388853&form=6&db=m Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33508434&form=6&db=m SIRT3 as a potential therapeutic target for heart failure. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33930006&form=6&db=m Genomics of aging: The role of sirtuin and metabolic health. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34028177&form=6&db=m The role of SIRT2 in vascular-related and heart-related diseases: A review. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34382399&form=6&db=m Omarigliptin Prevents TNF-?-Induced Cellular Senescence in Rat Aorta Vascular Smooth Muscle Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Carotid Artery Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23259556&form=6&db=m SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23892278&form=6&db=m The role of SIRT1 in ocular aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29199862&form=6&db=m Expression of SIRT1 and P53 in Rat Lens Epithelial cells in Experimentally Induced DM. causal interaction,unassigned 4,0 2.3.1.286 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29693113&form=6&db=m Role of Sirtuin 1 in the pathogenesis of ocular disease (Review). causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32010268&form=6&db=m Expression of miR-34a in cataract rats and its related mechanism. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.286 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32730875&form=6&db=m Activation of Sirtuin1 by lyceum barbarum polysaccharides in protection against diabetic cataract. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.3.1.286 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20622856&form=6&db=m A novel pathway regulates memory and plasticity via SIRT1 and miR-134. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27333745&form=6&db=m [SIRT1]. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25433241&form=6&db=m SIRT3 protects cells from hypoxia via PGC-1?- and MnSOD-dependent pathways. ongoing research,unassigned 4,0 2.3.1.286 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26014945&form=6&db=m Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease. therapeutic application,unassigned 4,0 2.3.1.286 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31905606&form=6&db=m Origin of Monocytes/Macrophages Contributing to Chronic Inflammation in Chagas Disease: SIRT1 Inhibition of FAK-NF?B-Dependent Proliferation and Proinflammatory Activation of Macrophages. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25696003&form=6&db=m Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.286 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21415417&form=6&db=m MITOCHONDRIAL BIOGENESIS FAILS IN SECONDARY BILIARY CIRRHOSIS IN RATS LEADING TO MITOCHONDRIAL DNA DEPLETION AND DELETIONS. causal interaction,unassigned 4,0 2.3.1.286 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25789761&form=6&db=m SIRT1/PGC-1? signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 2.3.1.286 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27818225&form=6&db=m Protective effects of SRT1720 via the HNF1?/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29328070&form=6&db=m Nerve growth factor upregulates sirtuin 1 expression in cholestasis: a potential therapeutic target. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Cholestasis, Extrahepatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25789761&form=6&db=m SIRT1/PGC-1? signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 2.3.1.286 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28112277&form=6&db=m The expression of SIRT1 regulates the metastaticplasticity of chondrosarcoma cells by inducing epithelial-mesenchymal transition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Choroidal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22275802&form=6&db=m Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2?. ongoing research,unassigned 4,0 2.3.1.286 Choroidal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23135526&form=6&db=m Expression of sirt1 in choroidal neovascular membranes. ongoing research,unassigned 4,0 2.3.1.286 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25440059&form=6&db=m A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19940103&form=6&db=m Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitis. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24549276&form=6&db=m Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3(+) T-regulatory cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25072851&form=6&db=m SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28552621&form=6&db=m Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.286 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31396314&form=6&db=m Systematic understanding of the mechanism and effects of Arctigenin attenuates inflammation in dextran sulfate sodium-induced acute colitis through suppression of NLRP3 inflammasome by SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32619377&form=6&db=m Dual role of sirtuin 1 in inflammatory bowel disease. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28552621&form=6&db=m Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16596166&form=6&db=m Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18755897&form=6&db=m miR-34a repression of SIRT1 regulates apoptosis. ongoing research,unassigned 4,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19404850&form=6&db=m Expression and prognostic significance of SIRT1 in ovarian epithelial tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19430421&form=6&db=m SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19433578&form=6&db=m SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22640743&form=6&db=m SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of ?-catenin. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22642300&form=6&db=m Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24469059&form=6&db=m A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24816737&form=6&db=m Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25105144&form=6&db=m The sirtuin 3 expression profile is associated with pathological and clinical outcomes in colon cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26141949&form=6&db=m CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28526414&form=6&db=m A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29807115&form=6&db=m Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30082156&form=6&db=m The clinicopathological significance of SIRT1 expression in colon cancer: An immunohistochemical study and meta-analysis. diagnostic usage,ongoing research,unassigned 4,4,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30410074&form=6&db=m Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31153640&form=6&db=m Mitochondrial NOS1 suppresses apoptosis in colon cancer cells through increasing SIRT3 activity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33455111&form=6&db=m The role of miR-141/ Sirt1 in colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19430421&form=6&db=m SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22149272&form=6&db=m SIRT1 and the clock gene machinery in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24009628&form=6&db=m SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24816737&form=6&db=m Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24890145&form=6&db=m Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25013930&form=6&db=m Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25307864&form=6&db=m Nuclear expression of histone deacetylases and their histone modifications predicts clinical outcome in colorectal cancer. diagnostic usage,ongoing research,unassigned 4,3,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25500546&form=6&db=m High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26219912&form=6&db=m Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells. ongoing research,unassigned 4,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26893713&form=6&db=m Expression and clinical significance of Sirt1 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26959057&form=6&db=m Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26975631&form=6&db=m SIRT1 promotes epithelial-mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28088387&form=6&db=m SIRT2 mediated antitumor effects of shikonin on metastatic colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28514749&form=6&db=m A variant in SIRT2 gene 3'-UTR is associated with susceptibility to colorectal cancer. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29807115&form=6&db=m Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30008852&form=6&db=m Knockout of SIRT4 decreases chemosensitivity to 5-FU in colorectal cancer cells. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30082156&form=6&db=m The clinicopathological significance of SIRT1 expression in colon cancer: An immunohistochemical study and meta-analysis. diagnostic usage,ongoing research,unassigned 4,4,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30410074&form=6&db=m Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30584257&form=6&db=m Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31258845&form=6&db=m ETHE1 overexpression promotes SIRT1 and PGC1? mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32098999&form=6&db=m Investigation of sirtuin 1 polymorphisms in relation to the risk of colorectal cancer by molecular subtype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32361710&form=6&db=m Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32697380&form=6&db=m SIRT2, a direct target of miR-212-5p, suppresses the proliferation and metastasis of colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32811824&form=6&db=m Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014852&form=6&db=m The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene? causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33073770&form=6&db=m Novel SIRT Inhibitor, MHY2256, Induces Cell Cycle Arrest, Apoptosis, and Autophagic Cell Death in HCT116 Human Colorectal Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23382833&form=6&db=m Peripheral blood monocyte Sirt1 expression is reduced in patients with coronary artery disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25582759&form=6&db=m Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: The role of sirtuin 1 gene variants in human coronary atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27123454&form=6&db=m In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions. causal interaction,diagnostic usage,unassigned 4,1,0 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27378396&form=6&db=m Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28043667&form=6&db=m A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28601780&form=6&db=m SIRT1 inhibition causes oxidative stress and inflammation in patients with coronary artery disease. causal interaction,unassigned 4,0 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29885463&form=6&db=m SIRT1 gene polymorphisms associated with decreased risk of atherosclerotic coronary artery disease. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30192743&form=6&db=m MicroRNA 199a Is Downregulated in Patients After Coronary Artery Bypass Graft Surgery and Is Associated with Increased Levels of Sirtuin 1 (SIRT 1) Protein and Major Adverse Cardiovascular Events at 3-Year Follow-Up. causal interaction,diagnostic usage,unassigned 4,1,0 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30227330&form=6&db=m SIRT3-mediated cardiac remodeling/repair following myocardial infarction. causal interaction,unassigned 4,0 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31577623&form=6&db=m Low serum level of sirtuin 1 predicts coronary atherosclerosis plaques during computed tomography angiography among an asymptomatic cohort. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32758009&form=6&db=m Reverse expression pattern of sirtuin-1 and histone deacetylase-9 in coronary artery disease. causal interaction,unassigned 4,0 2.3.1.286 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33250679&form=6&db=m Downregulation of Sirt1 is correlated to upregulation of p53 and increased apoptosis in epicardial adipose tissue of patients with coronary artery disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.3.1.286 Coronary Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29444200&form=6&db=m Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31142674&form=6&db=m A Yeast Suppressor Screen Used To Identify Mammalian SIRT1 as a Proviral Factor for Middle East Respiratory Syndrome Coronavirus Replication. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 2.3.1.286 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32558516&form=6&db=m [Coronavirus disease (COVID-19) and sirtuins]. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.3.1.286 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33578018&form=6&db=m The unbalanced p53/SIRT1 axis may impact lymphocyte homeostasis in COVID-19 patients. causal interaction,diagnostic usage,unassigned 4,1,0 2.3.1.286 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26862948&form=6&db=m Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28578695&form=6&db=m SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease. causal interaction,diagnostic usage,unassigned 4,1,0 2.3.1.286 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30484407&form=6&db=m Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer's Disease. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31471557&form=6&db=m Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23547115&form=6&db=m Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24383546&form=6&db=m SIRT1 Activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29494741&form=6&db=m SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Desmoplastic Small Round Cell Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25965594&form=6&db=m SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27123454&form=6&db=m In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions. causal interaction,diagnostic usage,unassigned 4,1,0 2.3.1.286 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29110598&form=6&db=m SIRT1 as a therapeutic target in diabetic complications. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33537003&form=6&db=m Epigenetic Regulation Associated With Sirtuin 1 in Complications of Diabetes Mellitus. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19455179&form=6&db=m SIRT1 and insulin resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21813271&form=6&db=m Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22203920&form=6&db=m Translating cell survival and cell longevity into treatment strategies with SIRT1. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23259556&form=6&db=m SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26422395&form=6&db=m SIRT1 and insulin resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27239324&form=6&db=m Effects of the small molecule SIRT1 activator, SRT2104 on arterial stiffness in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus. ongoing research,unassigned 4,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27749604&form=6&db=m SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28043667&form=6&db=m A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28395272&form=6&db=m The effect of hesperidin and quercetin on oxidative stress, NF-?B and SIRT1 levels in a STZ-induced experimental diabetes model. ongoing research,unassigned 4,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29164153&form=6&db=m SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29995800&form=6&db=m Influence of SIRT1 polymorphisms for diabetic foot susceptibility and severity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30498174&form=6&db=m Assessment of Sirtuin 3 and Sirtuin 4 Level in Patients with Diabetes Mellitus and Periodontitis: A Clinical Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30988688&form=6&db=m Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice. causal interaction,unassigned 4,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32486051&form=6&db=m SIRT1 Activation by Equisetum Arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32823525&form=6&db=m Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33537003&form=6&db=m Epigenetic Regulation Associated With Sirtuin 1 in Complications of Diabetes Mellitus. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33577446&form=6&db=m Sirtuin 1 rs7069102 polymorphism is associated with diabetic nephropathy in patients with type 2 diabetes mellitus. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34249264&form=6&db=m Quercetin protects islet ?-cells from oxidation-induced apoptosis via Sirt3 in T2DM. causal interaction,unassigned 4,0 2.3.1.286 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20008278&form=6&db=m Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21340626&form=6&db=m Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.286 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21813271&form=6&db=m Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23473025&form=6&db=m Novel SIRT1 Mutation Linked to Autoimmune Diabetes in Humans. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.286 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33220291&form=6&db=m Sirt1 attenuates diabetic keratopathy by regulating the endoplasmic reticulum stress pathway. ongoing research,unassigned 4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16098828&form=6&db=m Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. therapeutic application,unassigned 4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17090532&form=6&db=m SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18282481&form=6&db=m The Sirtuin family: therapeutic targets to treat diseases of aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18599274&form=6&db=m The role of sirtuin proteins in obesity. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18827827&form=6&db=m Sirtuins--novel therapeutic targets to treat age-associated diseases. therapeutic application,unassigned 4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19014491&form=6&db=m SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention--the TULIP Study. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19876588&form=6&db=m Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20601277&form=6&db=m Sirtuin activators: Designing molecules to extend life span. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21331741&form=6&db=m Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,3 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21871827&form=6&db=m SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22186191&form=6&db=m Oxidative stress, glutathione status, sirtuin and cellular stress response in type 2 diabetes. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22796566&form=6&db=m Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22885181&form=6&db=m Genetic analysis of the SIRT1 gene promoter in ventricular septal defects. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23259556&form=6&db=m SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23397292&form=6&db=m Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23834033&form=6&db=m Elevated microRNA-34a in obesity reduces NAD(+) levels and SIRT1 activity by directly targeting NAMPT. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23876548&form=6&db=m Association between low SIRT1 expression in visceral and subcutaneous adipose tissues and metabolic abnormalities in women with obesity and type 2 diabetes. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24199159&form=6&db=m SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24793418&form=6&db=m SIRT2 negatively regulates insulin resistance in C2C12 skeletal muscle cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25067957&form=6&db=m Targeting sirtuins for the treatment of diabetes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25342474&form=6&db=m Association between the SIRT1 mRNA Expression and Acute Coronary Syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25766107&form=6&db=m Sirtuins in Vascular Diseases: Emerging Roles and Therapeutic Potential. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26422395&form=6&db=m SIRT1 and insulin resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27123454&form=6&db=m In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions. causal interaction,diagnostic usage,unassigned 4,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27239324&form=6&db=m Effects of the small molecule SIRT1 activator, SRT2104 on arterial stiffness in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus. ongoing research,unassigned 4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27749604&form=6&db=m SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28810642&form=6&db=m Overexpressed eNOS upregulates SIRT1 expression and protects mouse pancreatic ? cells from apoptosis. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28830875&form=6&db=m Influences of Breakfast on Clock Gene Expression and Postprandial Glycemia in Healthy Individuals and Individuals With Diabetes: A Randomized Clinical Trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29164153&form=6&db=m SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29995800&form=6&db=m Influence of SIRT1 polymorphisms for diabetic foot susceptibility and severity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30072892&form=6&db=m Formononetin Treatment in Type 2 Diabetic Rats Reduces Insulin Resistance and Hyperglycemia. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30139387&form=6&db=m Linking a role of lncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes. diagnostic usage,ongoing research,unassigned 4,2,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30584213&form=6&db=m Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy in primary chondrocytes. causal interaction,unassigned 4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30988688&form=6&db=m Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice. causal interaction,unassigned 4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31377446&form=6&db=m In silico and in vitro identification of candidate SIRT1 activators from Indonesian medicinal plants compounds database. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32404204&form=6&db=m Autophagy-dependent and -independent modulation of oxidative and organellar stress in the diabetic heart by glucose-lowering drugs. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32455427&form=6&db=m Pro-inflammatory Cytokine Interleukin 1? Disrupts ? cell Circadian Clock Function and Regulation of Insulin Secretion. causal interaction,unassigned 4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33577446&form=6&db=m Sirtuin 1 rs7069102 polymorphism is associated with diabetic nephropathy in patients with type 2 diabetes mellitus. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33930006&form=6&db=m Genomics of aging: The role of sirtuin and metabolic health. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34249264&form=6&db=m Quercetin protects islet ?-cells from oxidation-induced apoptosis via Sirt3 in T2DM. causal interaction,unassigned 4,0 2.3.1.286 Diabetes, Gestational http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23956348&form=6&db=m Skeletal Muscle MnSOD, Mitochondrial Complex II, and SIRT3 Enzyme Activities Are Decreased in Maternal Obesity During Human Pregnancy and Gestational Diabetes Mellitus. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17765928&form=6&db=m Catalase alleviates cardiomyocyte dysfunction in diabetes: role of Akt, Forkhead transcriptional factor and silent information regulator 2. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20008278&form=6&db=m Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23932046&form=6&db=m An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy. causal interaction,unassigned 4,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24363305&form=6&db=m Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25965594&form=6&db=m SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32140263&form=6&db=m SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32296036&form=6&db=m SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32486051&form=6&db=m SIRT1 Activation by Equisetum Arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34028177&form=6&db=m The role of SIRT2 in vascular-related and heart-related diseases: A review. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Diabetic Foot http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29995800&form=6&db=m Influence of SIRT1 polymorphisms for diabetic foot susceptibility and severity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20854812&form=6&db=m Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: involvement of SIRT1 and TGF-?1 pathway. causal interaction,unassigned 4,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21331741&form=6&db=m Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,3 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23793837&form=6&db=m Nephroprotective action of sirtuin 1 (SIRT1). causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24379901&form=6&db=m Renal protective effects of resveratrol. causal interaction,unassigned 4,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25920189&form=6&db=m [The role of SIRT1 in the treatment of diabetic nephropathy]. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29689547&form=6&db=m SIRT3 Facilitates Amniotic Fluid Stem Cells to Repair Diabetic Nephropathy Through Protecting Mitochondrial Homeostasis by Modulation of Mitophagy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30110438&form=6&db=m Correlations between SIRT1 gene polymorphisms and diabetic kidney disease. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30386303&form=6&db=m SIRT1 Is a Potential Drug Target for Treatment of Diabetic Kidney Disease. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30988688&form=6&db=m Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice. causal interaction,unassigned 4,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32439965&form=6&db=m Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32534886&form=6&db=m Role of ketogenic starvation sensors in mediating the renal protective effects of SGLT2 inhibitors in type 2 diabetes. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33121427&form=6&db=m SIRT1: Mechanism and Protective in Diabetic Nephropathy. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33577446&form=6&db=m Sirtuin 1 rs7069102 polymorphism is associated with diabetic nephropathy in patients with type 2 diabetes mellitus. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33748285&form=6&db=m Inhibition of miRNA-155 Alleviates High Glucose-Induced Podocyte Inflammation by Targeting SIRT1 in Diabetic Mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29693113&form=6&db=m Role of Sirtuin 1 in the pathogenesis of ocular disease (Review). causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33174070&form=6&db=m The role of sirt1 in the retinal ganglion cells cultured by high glucose. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,3 2.3.1.286 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33517190&form=6&db=m Melatonin attenuates oxidative stress and inflammation of Müller cells in diabetic retinopathy via activating the Sirt1 pathway. causal interaction,unassigned 4,0 2.3.1.286 DNA Repair-Deficiency Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25440059&form=6&db=m A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23547115&form=6&db=m Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29494741&form=6&db=m SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23547115&form=6&db=m Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29494741&form=6&db=m SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Endocrine System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34504573&form=6&db=m Resveratrol reduces the progression of titanium particle-induced osteolysis via the Wnt/?-catenin signaling pathway in vivo and in vitro. therapeutic application,unassigned 4,0 2.3.1.286 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25270091&form=6&db=m SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26367491&form=6&db=m Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 2.3.1.286 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26862948&form=6&db=m Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32896495&form=6&db=m Inhibitory effect of resveratrol on the growth and angiogenesis of human endometrial tissue in an In Vitro three-dimensional model of endometriosis. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33718673&form=6&db=m MiRNA 34-a regulate SIRT-1 and Foxo-1 expression in endometriosis. causal interaction,unassigned 4,0 2.3.1.286 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34356330&form=6&db=m Is There a Balance in Oxidative-Antioxidant Status in Blood Serum of Patients with Advanced Endometriosis? causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.286 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34514931&form=6&db=m A potential role of Sirtuin3 and its target enzyme activities in patients with ovarian endometrioma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24573134&form=6&db=m Interferon ? protects against lethal endotoxic and septic shock through SIRT1 upregulation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24896770&form=6&db=m Sirt1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31201798&form=6&db=m Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Enterocolitis, Necrotizing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34296298&form=6&db=m miR?34a increases inflammation and oxidative stress levels in patients with necrotizing enterocolitis by downregulating SIRT1 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 2.3.1.286 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26945677&form=6&db=m Targeting of microRNA-199a-5p protects against pilocarpine-induced status epilepticus and seizure damage via SIRT1-p53 cascade. diagnostic usage,ongoing research,unassigned 4,4,0 2.3.1.286 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29778462&form=6&db=m Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33747170&form=6&db=m miR-135a-5p inhibitor protects glial cells against apoptosis via targeting SIRT1 in epilepsy. therapeutic application,unassigned 4,0 2.3.1.286 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23193674&form=6&db=m [Deacetylase SIRT1 and vascular endothelial function]. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29110598&form=6&db=m SIRT1 as a therapeutic target in diabetic complications. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26662958&form=6&db=m Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29656187&form=6&db=m SIRT1 expression regulates the transformation of resistant esophageal cancer cells via the epithelial-mesenchymal transition. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26662958&form=6&db=m Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29636061&form=6&db=m SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29739048&form=6&db=m Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31684999&form=6&db=m ADC correlation with Sirtuin1 to assess early chemoradiotherapy response of locally advanced esophageal carcinoma patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 2.3.1.286 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28684630&form=6&db=m Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31852393&form=6&db=m Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.3.1.286 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33423524&form=6&db=m Role of Klotho in the Development of Essential Hypertension. causal interaction,unassigned 4,0 2.3.1.286 Eye Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29693113&form=6&db=m Role of Sirtuin 1 in the pathogenesis of ocular disease (Review). causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Eye Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31900639&form=6&db=m SIRT1 is required for the neuroprotection of resveratrol on retinal ganglion cells after retinal ischemia-reperfusion injury in mice. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Fasciitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21103071&form=6&db=m Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22553202&form=6&db=m Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25267960&form=6&db=m A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25358448&form=6&db=m Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients. diagnostic usage,ongoing research,unassigned 4,3,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26064858&form=6&db=m SIRT3 as a Regulator of Non-alcoholic Fatty Liver Disease. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28533219&form=6&db=m Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30785444&form=6&db=m Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31225483&form=6&db=m Foie gras and liver regeneration: a fat dilemma. ongoing research,unassigned 4,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31949882&form=6&db=m Renalase Attenuates Mouse Fatty Liver Ischemia/Reperfusion Injury through Mitigating Oxidative Stress and Mitochondrial Damage via Activating SIRT1. causal interaction,unassigned 4,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32230804&form=6&db=m Low Expression of Sirtuin 1 in the Dairy Cows with Mild Fatty Liver Alters Hepatic Lipid Metabolism. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32912335&form=6&db=m SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1?-LIPIN 1 pathway and increasing CD36 through Nrf2. causal interaction,unassigned 4,0 2.3.1.286 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33098868&form=6&db=m miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload. ongoing research,unassigned 4,0 2.3.1.286 Fatty Liver, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18239056&form=6&db=m Involvement of mammalian sirtuin 1 in the action of ethanol in the liver. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Fragile X Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22730114&form=6&db=m Sirtuin activators and inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Friedreich Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22394676&form=6&db=m Friedreich's Ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase. causal interaction,unassigned 4,0 2.3.1.286 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Giant Cell Arteritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34073102&form=6&db=m An Insight into Giant Cell Arteritis Pathogenesis: Evidence for Oxidative Stress and SIRT1 Downregulation. causal interaction,unassigned 4,0 2.3.1.286 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23892278&form=6&db=m The role of SIRT1 in ocular aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29693113&form=6&db=m Role of Sirtuin 1 in the pathogenesis of ocular disease (Review). causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31900639&form=6&db=m SIRT1 is required for the neuroprotection of resveratrol on retinal ganglion cells after retinal ischemia-reperfusion injury in mice. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Glaucoma, Open-Angle http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29384425&form=6&db=m The relationship between HDAC6, CXCR3, and SIRT1 genes expression levels with progression of primary open-angle glaucoma. diagnostic usage,unassigned 4,0 2.3.1.286 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26141949&form=6&db=m CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29991742&form=6&db=m A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.3.1.286 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30213795&form=6&db=m SIRT2-mediated inactivation of p73 is required for glioblastoma tumorigenicity. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19166820&form=6&db=m Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22166219&form=6&db=m SIRT2 activity is required for the survival of C6 glioma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25096191&form=6&db=m SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of "cancer cells with neural stemness" in a p53-dependent manner. causal interaction,unassigned 4,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27166997&form=6&db=m miR-133b inhibits glioma cell proliferation and invasion by targeting Sirt1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28475330&form=6&db=m Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29057547&form=6&db=m Knockdown of long non-coding RNA ANRIL inhibits proliferation, migration, and invasion but promotes apoptosis of human glioma cells by upregulation of miR-34a. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30119208&form=6&db=m Exendin-4 inhibits glioma cell migration, invasion and epithelial-to-mesenchymal transition through GLP-1R/sirt3 pathway. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30464504&form=6&db=m Sirt3 enhances glioma cell viability by stabilizing Ku70-BAX interaction. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30592284&form=6&db=m miR?34a derived from mesenchymal stem cells stimulates senescence in glioma cells by inducing DNA damage. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30675198&form=6&db=m Sirtuin 7 promotes glioma proliferation and invasion through activation of the ERK/STAT3 signaling pathway. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930981&form=6&db=m Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31186751&form=6&db=m Sirtuin 1 knockdown inhibits glioma cell proliferation and potentiates temozolomide toxicity via facilitation of reactive oxygen species generation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31957839&form=6&db=m Circ_0005075 stimulates the proliferation and metastasis of glioma via downregulating SIRT1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32118205&form=6&db=m Noninvasive quantification of SIRT1 expression-activity and pharmacologic inhibition in a rat model of intracerebral glioma using 2-[18F]BzAHA PET/CT/MRI. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4 2.3.1.286 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32710757&form=6&db=m Sirtuin activation targets IDH-mutant tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25501752&form=6&db=m Resveratrol possesses protective effects in a pristane-induced lupus mouse model. causal interaction,unassigned 4,0 2.3.1.286 Glomus Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20842108&form=6&db=m Intra-arterial Targeted Islet-specific Expression of Sirt1 Protects ? Cells From Streptozotocin-induced Apoptosis in Mice. causal interaction,unassigned 4,0 2.3.1.286 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28533219&form=6&db=m Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33285413&form=6&db=m Increased Sirt1 secreted from visceral white adipose tissue is associated with improved glucose tolerance in obese Nrf2-deficient mice. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30600470&form=6&db=m Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2 2.3.1.286 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26722027&form=6&db=m A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26319214&form=6&db=m Oxidative stress and ROS metabolism via down-regulation of sirtuin 3 expression in Cmah-null mice affect hearing loss. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27255815&form=6&db=m Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24020000&form=6&db=m The Roles of SIRT1 in Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25114706&form=6&db=m The Comparative Study on Expression of SIRT1 Signal Transduction by Xuefuzhuyu Capsule. causal interaction,unassigned 4,0 2.3.1.286 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27561793&form=6&db=m 1,25(OH)2 D3 improves cardiac dysfunction, hypertrophy and fibrosis through PARP1/SIRT1/mTOR related mechanisms in Type 1 diabetes. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.286 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27614093&form=6&db=m Receptor-Interacting Protein 140 represses Sirtuin 3 to facilitate hypertrophy, mitochondrial dysfunction and energy metabolic dysfunction in cardiomyocytes. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29643974&form=6&db=m SIRT3: A New Regulator of Cardiovascular Diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32724473&form=6&db=m Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19260974&form=6&db=m Silent information regulator, Sirtuin 1, and age-related diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21964378&form=6&db=m Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice. causal interaction,unassigned 4,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22622703&form=6&db=m Emerging beneficial roles of sirtuins in heart failure. ongoing research,therapeutic application,unassigned 2,4,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24363305&form=6&db=m Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24535859&form=6&db=m Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25782072&form=6&db=m High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26233702&form=6&db=m Reduced SIRT1 expression correlates with enhanced oxidative stress in compensated and decompensated heart failure. causal interaction,unassigned 4,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26391855&form=6&db=m Caffeic acid ethanolamide prevents cardiac dysfunction through sirtuin dependent cardiac bioenergetics preservation. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28302481&form=6&db=m Metformin improves cardiac function in mice with heart failure after myocardial infarction by regulating mitochondrial energy metabolism. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30132870&form=6&db=m Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30458637&form=6&db=m Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases. causal interaction,unassigned 4,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31269804&form=6&db=m Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31425381&form=6&db=m SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION. causal interaction,unassigned 4,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31464387&form=6&db=m Mitochondrial Hyperacetylation in the Failing Hearts of Obese Patients Mediated Partly by a Reduction in SIRT3: The Involvement of the Mitochondrial Permeability Transition Pore. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31885811&form=6&db=m Cardiac Rehabilitation Increases SIRT1 Activity and ?-Hydroxybutyrate Levels and Decreases Oxidative Stress in Patients with HF with Preserved Ejection Fraction. diagnostic usage,ongoing research,unassigned 4,2,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32140263&form=6&db=m SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32296036&form=6&db=m SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33238655&form=6&db=m Sirt1 Activity in PBMCs as a Biomarker of Different Heart Failure Phenotypes. diagnostic usage,therapeutic application,unassigned 4,1,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33247214&form=6&db=m MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33508434&form=6&db=m SIRT3 as a potential therapeutic target for heart failure. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34028177&form=6&db=m The role of SIRT2 in vascular-related and heart-related diseases: A review. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Heart Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21865267&form=6&db=m Expression of SIRT1 in Gastric Cardiac Cancer and Its Clinicopathologic Significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Heart Septal Defects, Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22885181&form=6&db=m Genetic analysis of the SIRT1 gene promoter in ventricular septal defects. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 2.3.1.286 Hemangiosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30842143&form=6&db=m SIRT1 Expression Is Associated With Cell Proliferation in Angiosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18774777&form=6&db=m SIRTUIN 1: regulating the regulator. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24855208&form=6&db=m SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.3.1.286 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27725192&form=6&db=m AML1-ETO promotes SIRT1 expression to enhance leukemogenesis of t(8;21) acute myeloid leukemia. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28118604&form=6&db=m Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy. therapeutic application,unassigned 4,0 2.3.1.286 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31090265&form=6&db=m Role of SIRT1 in hematologic malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 2.3.1.286 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34407842&form=6&db=m SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.286 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28578410&form=6&db=m Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice. ongoing research,unassigned 4,0 2.3.1.286 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23137540&form=6&db=m SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25131770&form=6&db=m SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28135713&form=6&db=m MicroRNA-141 Targets Sirt1 and Inhibits Autophagy to Reduce HBV Replication. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30111572&form=6&db=m Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis via the AKT/GSK-3?/?-Catenin Signaling Pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32493816&form=6&db=m An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone Lysine Methyltransferases. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.286 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33931611&form=6&db=m Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29039533&form=6&db=m SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17397914&form=6&db=m SIRT1 and neuronal diseases. causal interaction,unassigned 4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19650880&form=6&db=m Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway. causal interaction,unassigned 4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22179316&form=6&db=m Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. therapeutic application,unassigned 4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22179319&form=6&db=m Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22642300&form=6&db=m Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22648412&form=6&db=m trans-(-)-?-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23689277&form=6&db=m Sirtuin deacetylases in neurodegenerative diseases of aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25536118&form=6&db=m SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26819971&form=6&db=m Sirt1 in cerebral ischemia. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27590140&form=6&db=m Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington's Disease Models. causal interaction,unassigned 4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27686535&form=6&db=m Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28449871&form=6&db=m SIRT3 and mitochondrial metabolism in neurodegenerative diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30019499&form=6&db=m SIRT1 is increased in affected brain regions and hypothalamic metabolic pathways are altered in Huntington disease. causal interaction,unassigned 4,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33597872&form=6&db=m SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33876629&form=6&db=m Discovery of Dihydro-1,4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin-1. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33877561&form=6&db=m Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34151764&form=6&db=m Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27279707&form=6&db=m Intrathecal Injection of Resveratrol Attenuates Burn Injury Pain by Activating Spinal Sirtuin 1. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27749604&form=6&db=m SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29222643&form=6&db=m Overexpression of SIRT2 Alleviates Neuropathic Pain and Neuroinflammation Through Deacetylation of Transcription Factor Nuclear Factor-Kappa B. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30342528&form=6&db=m Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31938369&form=6&db=m Involvement of spinal SIRT1 in development of chronic constriction injury induced neuropathic pain in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,2 2.3.1.286 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33395186&form=6&db=m Upregulation of silent information regulator 1 alleviates mitochondrial dysfunction in the trigeminal nucleus caudalis in a rat model of chronic migraine. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17646659&form=6&db=m Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17646659&form=6&db=m Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19286634&form=6&db=m Protective Role of SIRT1 in Diabetic Vascular Dysfunction. causal interaction,unassigned 4,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21965330&form=6&db=m Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22124463&form=6&db=m Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin. causal interaction,unassigned 4,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23761075&form=6&db=m Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes. causal interaction,unassigned 4,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28258028&form=6&db=m Resveratrol ameliorates hyperglycemia-induced renal tubular oxidative stress damage via modulating the SIRT1/FOXO3a pathway. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30072892&form=6&db=m Formononetin Treatment in Type 2 Diabetic Rats Reduces Insulin Resistance and Hyperglycemia. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19996381&form=6&db=m SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24759758&form=6&db=m Novel PPAR pan agonist, ZBH ameliorates hyperlipidemia and insulin resistance in high fat diet induced hyperlipidemic hamster. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28375738&form=6&db=m Sirt3 Deficiency Increased the Vulnerability of Pancreatic Beta Cells to Oxidative Stress-Induced Dysfunction. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31577623&form=6&db=m Low serum level of sirtuin 1 predicts coronary atherosclerosis plaques during computed tomography angiography among an asymptomatic cohort. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Hyperphosphatemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22133824&form=6&db=m [Bone and calcium update; diagnosis and therapy of bone metabolism disease update. Regulatory Mechanism of Mammalian Sirtuin SIRT1 in Vascular calcification: impact of vascular smooth muscle cell senescence]. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23698802&form=6&db=m SIRT1, heme oxygenase-1 and NO-mediated vasodilation in a human model of endogenous angiotensin II type 1 receptor antagonism: implications for hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25284742&form=6&db=m Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans. causal interaction,unassigned 4,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26273643&form=6&db=m Regulation of Cell Cycle Regulators by SIRT1 Contributes to Resveratrol-Mediated Prevention of Pulmonary Arterial Hypertension. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27620389&form=6&db=m Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28043667&form=6&db=m A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28684630&form=6&db=m Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28825991&form=6&db=m Resveratrol prevents the combined maternal plus postweaning high-fat-diets-induced hypertension in male offspring. ongoing research,therapeutic application,unassigned 1,4,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29369849&form=6&db=m Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation: role in pulmonary arterial hypertension. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29578961&form=6&db=m Sirtuin 1 as a potential therapeutic target in pulmonary artery hypertension. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30227325&form=6&db=m 15-HETE protects pulmonary artery smooth muscle cells against apoptosis via SIRT1 regulation during hypoxia. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30458637&form=6&db=m Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases. causal interaction,unassigned 4,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30717220&form=6&db=m Effect of Sucrose Ingestion at the End of a Critical Window that Increases Hypertension Susceptibility on Peripheral Mechanisms Regulating Blood Pressure in Rats. Role of Sirtuins 1 and 3. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31425381&form=6&db=m SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION. causal interaction,unassigned 4,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31852393&form=6&db=m Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32303670&form=6&db=m Effect of Aldosterone on Senescence and Proliferation Inhibition of Endothelial Progenitor Cells Induced by Sirtuin 1 (SIRT1) in Pulmonary Arterial Hypertension. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32887498&form=6&db=m Decreased Urinary Levels of SIRT1 as Non-Invasive Biomarker of Early Renal Damage in Hypertension. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33488923&form=6&db=m NAMPT/SIRT1 Attenuate Ang II-Induced Vascular Remodeling and Vulnerability to Hypertension by Inhibiting the ROS/MAPK Pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34270373&form=6&db=m Angiotensin II-induced overexpression of sirtuin 1 contributes to enhanced expression of Gi? proteins and hyperproliferation of vascular smooth muscle cells. causal interaction,unassigned 4,0 2.3.1.286 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34328346&form=6&db=m Childhood psychosocial stress is linked with impaired vascular endothelial function, lower SIRT1, and oxidative stress in young adulthood. causal interaction,unassigned 4,0 2.3.1.286 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26379395&form=6&db=m MiR-9a-5p regulates proliferation and migration of hepatic stellate cells under pressure through inhibition of Sirt1. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19142216&form=6&db=m Sirt1 hyperexpression in SHR heart related to left ventricular hypertrophy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 2.3.1.286 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30230925&form=6&db=m Left ventricular hypertrophy is associated with increased sirtuin level in newly diagnosed hypertensive patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17646659&form=6&db=m Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33165144&form=6&db=m Fetal Hypothyroidism Impairs Aortic Vasorelaxation Responses in Adulthood: Involvement of Hydrogen Sulfide and Nitric Oxide Cross talk. causal interaction,diagnostic usage,unassigned 4,1,0 2.3.1.286 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32139663&form=6&db=m Sirt1 antisense long non-coding RNA attenuates pulmonary fibrosis through sirt1-mediated epithelial-mesenchymal transition. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29777578&form=6&db=m Sirt3 deficiency impairs neurovascular recovery in ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30639123&form=6&db=m Maresin 1 attenuates the inflammatory response and mitochondrial damage in mice with cerebral ischemia/reperfusion in a SIRT1-dependent manner. ongoing research,therapeutic application,unassigned 1,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22087287&form=6&db=m Involvement of FOXO transcription factors, TRAIL-FasL/Fas, and sirtuin proteins family in canine coronavirus type II-induced apoptosis. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24862934&form=6&db=m Cryptosporidium parvum induces SIRT1 expression in host epithelial cells through downregulating let-7i. ongoing research,unassigned 4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25738568&form=6&db=m Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26031763&form=6&db=m Nutraceutical activators of AMPK/Sirt1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26135889&form=6&db=m Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26641650&form=6&db=m Sirt1 Activation Markedly Alters Transcription Profiles and Improves Outcome in Experimental Sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26974318&form=6&db=m PHARMACOLOGICAL SIRT1 ACTIVATION IMPROVES MORTALITY AND MARKEDLY ALTERS TRANSCRIPTIONAL PROFILES THAT ACCOMPANY EXPERIMENTAL SEPSIS. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28894448&form=6&db=m Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29081026&form=6&db=m 2,3,7,8-Tetrachlorodibenzo-p-dioxin influences bovine herpesvirus 1 replication through upregulation of SIRT3 and cytoskeletal reorganization. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29535539&form=6&db=m SIRT1 overexpression protects non-small cell lung cancer cells against osteopontin-induced epithelial-mesenchymal transition by suppressing NF-?B signaling. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29693338&form=6&db=m Sirt1 Gene Expression and Gastric Epithelial Cells Tumor Stage in Patients with Helicobacter pylori Infection causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30111572&form=6&db=m Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis via the AKT/GSK-3?/?-Catenin Signaling Pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30774023&form=6&db=m SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30910830&form=6&db=m Crosstalk of PD-1 signaling with the SIRT1/FOXO-1 axis during the progression of visceral leishmaniasis. causal interaction,unassigned 4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31092575&form=6&db=m SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to Vesicular Stomatitis Virus Oncolysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31142674&form=6&db=m A Yeast Suppressor Screen Used To Identify Mammalian SIRT1 as a Proviral Factor for Middle East Respiratory Syndrome Coronavirus Replication. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31289184&form=6&db=m Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31505260&form=6&db=m SIRT2: Controversy and multiple roles in disease and physiology. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32558516&form=6&db=m [Coronavirus disease (COVID-19) and sirtuins]. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32692207&form=6&db=m The clinical significance of the SIRT2 expression level in the early stage of sepsis patients. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32835604&form=6&db=m Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33263643&form=6&db=m Clinical significance of sirtuin 1 level in sepsis: correlation with disease risk, severity, and mortality risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33373810&form=6&db=m Sirt1 activation negatively regulates overt apoptosis in Mtb-infected macrophage through Bax. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33669990&form=6&db=m The Pleiotropic Function of Human Sirtuins as Modulators of Metabolic Pathways and Viral Infections. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34060486&form=6&db=m Histone deficiency and accelerated replication stress in T cell aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34421917&form=6&db=m Warm, Sweetened Milk at the Twilight of Immunity - Alzheimer's Disease - Inflammaging, Insulin Resistance, M. paratuberculosis and Immunosenescence. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Infertility, Male http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29359516&form=6&db=m Seminal SIRT1 expression in infertile oligoasthenoteratozoospermic men with varicocoele. causal interaction,unassigned 4,0 2.3.1.286 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24549276&form=6&db=m Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3(+) T-regulatory cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25072851&form=6&db=m SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32619377&form=6&db=m Dual role of sirtuin 1 in inflammatory bowel disease. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32636719&form=6&db=m The Protection Effect of Resveratrol Against Radiation-Induced Inflammatory Bowel Disease via NLRP-3 Inflammasome Repression in Mice. ongoing research,therapeutic application,unassigned 2,4,0 2.3.1.286 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26865910&form=6&db=m Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17646659&form=6&db=m Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18599274&form=6&db=m The role of sirtuin proteins in obesity. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18928399&form=6&db=m Opposite Effects of Metabolic Syndrome and Calorie Restriction on Thrombotic Disease: Head and Tail of Same Coin-Resveratrol's Role. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19014491&form=6&db=m SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention--the TULIP Study. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19103747&form=6&db=m SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19260974&form=6&db=m Silent information regulator, Sirtuin 1, and age-related diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19455179&form=6&db=m SIRT1 and insulin resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19996381&form=6&db=m SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20068143&form=6&db=m Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20107110&form=6&db=m SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20651844&form=6&db=m Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21965330&form=6&db=m Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22570137&form=6&db=m Short-Term Treatment With Rapamycin and Dietary Restriction Have Overlapping and Distinctive Effects in Young Mice. ongoing research,unassigned 4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22913271&form=6&db=m Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22967499&form=6&db=m Leucine Supplementation Increases SIRT1 Expression and Prevents Mitochondrial Dysfunction and Metabolic Disorders in High Fat Diet-induced Obese Mice. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23292098&form=6&db=m SIRT1 interacts with metabolic transcriptional factors in the pancreas of insulin-resistant and calorie-restricted rats. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23457303&form=6&db=m Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23933590&form=6&db=m Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: A pilot study. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24199159&form=6&db=m SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24567379&form=6&db=m Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24759758&form=6&db=m Novel PPAR pan agonist, ZBH ameliorates hyperlipidemia and insulin resistance in high fat diet induced hyperlipidemic hamster. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24793418&form=6&db=m SIRT2 negatively regulates insulin resistance in C2C12 skeletal muscle cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25267960&form=6&db=m A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25526506&form=6&db=m Serum sirtuin 1 levels in patients with polycystic ovary syndrome. diagnostic usage,ongoing research,unassigned 4,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25808216&form=6&db=m Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26064858&form=6&db=m SIRT3 as a Regulator of Non-alcoholic Fatty Liver Disease. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26422395&form=6&db=m SIRT1 and insulin resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27000941&form=6&db=m SIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts Endothelial-Dependent Vasorelaxation in Mice and Human with Obesity. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27035655&form=6&db=m CLOCK and BMAL1 regulate muscle insulin sensitivity via SIRT1 in male mice. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28099528&form=6&db=m iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-?B and p53. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28578347&form=6&db=m Consumption of a Mango Fruit Powder Protects Mice from High-Fat Induced Insulin Resistance and Hepatic Fat Accumulation. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29050301&form=6&db=m MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1). causal interaction,unassigned 4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29164153&form=6&db=m SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29236311&form=6&db=m miR-221 negatively regulates inflammation and insulin sensitivity in white adipose tissue by repression of sirtuin-1 (SIRT1). causal interaction,unassigned 4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30072892&form=6&db=m Formononetin Treatment in Type 2 Diabetic Rats Reduces Insulin Resistance and Hyperglycemia. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30121911&form=6&db=m Modulation of the Inflammatory Status of Macrophages and Their Paracrine Effect on the Sensitivity of Adipocytes to Insulin with Sirtuin and PPAR? Receptor Activators. ongoing research,unassigned 4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30536334&form=6&db=m HOTAIR participates in hepatic insulin resistance via regulating SIRT1. diagnostic usage,ongoing research,unassigned 4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30620711&form=6&db=m The effect of adipocyte-macrophage cross-talk in obesity-related breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30696833&form=6&db=m Suppression of SIRT1 in Diabetic Conditions Induces Osteogenic Differentiation of Human Vascular Smooth Muscle Cells via RUNX2 Signalling. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31296102&form=6&db=m Adipose-specific knockdown of Sirt1 results in obesity and insulin resistance by promoting exosomes release. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31332900&form=6&db=m Metformin in contrast to berberine reversed arsenic-induced oxidative stress in mitochondria from rat pancreas probably via Sirt3-dependent pathway. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31526389&form=6&db=m Effects of metformin and Exenatide on insulin resistance and AMPK?-SIRT1 molecular pathway in PCOS rats. ongoing research,unassigned 4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31778646&form=6&db=m DEL-1 ameliorates high-fat diet-induced insulin resistance in mouse skeletal muscle through SIRT1/SERCA2-mediated ER stress suppression. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31813865&form=6&db=m The effects of Sea buckthorn seed protein on glucose metabolism in streptozotocin-induced diabetic ICR mice. ongoing research,unassigned 4,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31900863&form=6&db=m Alzheimer's Disease and Diabetes: Insulin Signaling as the Bridge Linking Two Pathologies. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32320732&form=6&db=m SIRT1 Regulation in Ageing and Obesity. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32486051&form=6&db=m SIRT1 Activation by Equisetum Arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33285413&form=6&db=m Increased Sirt1 secreted from visceral white adipose tissue is associated with improved glucose tolerance in obese Nrf2-deficient mice. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22730114&form=6&db=m Sirtuin activators and inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22152608&form=6&db=m Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26505388&form=6&db=m Resveratrol could reverse the expression of SIRT1 and MMP-1 in vitro. ongoing research,unassigned 4,0 2.3.1.286 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30420619&form=6&db=m Small molecule natural compound agonist of SIRT3 as a therapeutic target for the treatment of intervertebral disc degeneration. therapeutic application,unassigned 4,0 2.3.1.286 Intervertebral Disc Displacement http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22152608&form=6&db=m Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Iron Deficiencies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28287409&form=6&db=m Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Iron Overload http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33098868&form=6&db=m miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload. ongoing research,unassigned 4,0 2.3.1.286 Iron Overload http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33233553&form=6&db=m SIRT3 Deficiency Sensitizes Angiotensin-II-Induced Renal Fibrosis. causal interaction,unassigned 4,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23201684&form=6&db=m The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. therapeutic application,unassigned 4,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26219598&form=6&db=m Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28527875&form=6&db=m Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29777578&form=6&db=m Sirt3 deficiency impairs neurovascular recovery in ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30519156&form=6&db=m The Role of Sirt1 in Ischemic Stroke: Pathogenesis and Therapeutic Strategies. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31208274&form=6&db=m Sirtuin 3 promotes microglia migration by upregulating CX3CR1. ongoing research,unassigned 4,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32912518&form=6&db=m Localization and Expression of Sirtuins 1, 2, 6 and Plasticity-Related Proteins in the Recovery Period after a Photothrombotic Stroke in Mice. ongoing research,unassigned 4,0 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32931562&form=6&db=m Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33616302&form=6&db=m Overexpression of sirtuin 2 and its association with prognosis in acute ischemic stroke patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.286 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17180656&form=6&db=m Strong expression of a longevity-related protein, SIRT1, in Bowen's disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34482974&form=6&db=m Sirtuin 3 inhibits nuclear factor-?B signaling activated by a fatty acid challenge in bovine mammary epithelial cells. causal interaction,unassigned 4,0 2.3.1.286 Kidney Calculi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30588609&form=6&db=m Sirtuin 3 suppresses the formation of renal calcium oxalate crystals through promoting M2 polarization of macrophages. causal interaction,unassigned 4,0 2.3.1.286 Kidney Calculi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30674870&form=6&db=m Sirt3 suppresses calcium oxalate-induced renal tubular epithelial cell injury via modification of FoxO3a-mediated autophagy. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17098745&form=6&db=m SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25587857&form=6&db=m Sirtuin 1: A Target for Kidney diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28146117&form=6&db=m Anti-Fibrotic Effect of Losartan, an Angiotensin II Receptor Blocker, Is Mediated through Inhibition of ER Stress via Up-Regulation of SIRT1, Followed by Induction of HO-1 and Thioredoxin. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28339034&form=6&db=m The Sirt1 activator, SRT1720, attenuates renal fibrosis by inhibiting CTGF and oxidative stress. therapeutic application,unassigned 4,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28615249&form=6&db=m Reduction in podocyte SIRT1 accelerates kidney injury in aging mice. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29712732&form=6&db=m Sirtuins in Renal Health and Disease. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30386303&form=6&db=m SIRT1 Is a Potential Drug Target for Treatment of Diabetic Kidney Disease. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31396333&form=6&db=m Ghrelin-mediated pathway in Apolipoprotein-E deficient mice: a survival system. therapeutic application,unassigned 4,0 2.3.1.286 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30095923&form=6&db=m SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Leiomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21819639&form=6&db=m Sir2-Related Protein 1 from Leishmania amazonensis is a glycosylated NAD+-dependent deacetylase. ongoing research,therapeutic application,unassigned 1,4,0 2.3.1.286 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25738568&form=6&db=m Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Lentivirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25471124&form=6&db=m Effect of shikonin on multidrug resistance in HepG2: The role of SIRT1. ongoing research,unassigned 4,0 2.3.1.286 Lentivirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29896416&form=6&db=m SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway. ongoing research,unassigned 4,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22207684&form=6&db=m The role of Sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22322739&form=6&db=m High expression of the longevity gene product SIRT1, and apoptosis induction by sirtinol in adult T-cell leukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22340598&form=6&db=m Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23519155&form=6&db=m Roles of SIRT1 in leukemogenesis. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24855208&form=6&db=m SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25664004&form=6&db=m SIRT1 counteracted the activation of STAT3 and NF-?B to repress the gastric cancer growth. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26049753&form=6&db=m Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31090265&form=6&db=m Role of SIRT1 in hematologic malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32037392&form=6&db=m Ginsenoside Rg1 Inhibits Cell Proliferation and Induces Markers of Cell Senescence in CD34+CD38- Leukemia Stem Cells Derived from KG1? Acute Myeloid Leukemia Cells by Activating the Sirtuin 1 (SIRT1)/Tuberous Sclerosis Complex 2 (TSC2) Signaling Pathway. diagnostic usage,ongoing research,unassigned 4,4,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32486166&form=6&db=m Albendazole-Induced SIRT3 Upregulation Protects Human Leukemia K562 Cells from the Cytotoxicity of MCL1 Suppression. ongoing research,unassigned 4,0 2.3.1.286 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32587297&form=6&db=m Activation of SIRT6 by DNA hypomethylating agents and clinical consequences on combination therapy in leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23429453&form=6&db=m Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26631723&form=6&db=m Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23322738&form=6&db=m Tenovin-D3, a Novel Small-Molecule Inhibitor of Sirtuin SirT2, Increases p21 (CDKN1A) Expression in a p53-Independent Manner. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.286 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23519155&form=6&db=m Roles of SIRT1 in leukemogenesis. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24855208&form=6&db=m SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.3.1.286 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26049753&form=6&db=m Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.3.1.286 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26282546&form=6&db=m Emerging Drug Target In Pancreatic Cancer: Placing Sirtuin 1 on the Canvas. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31090265&form=6&db=m Role of SIRT1 in hematologic malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 2.3.1.286 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32823525&form=6&db=m Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.286 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22207684&form=6&db=m The role of Sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22207684&form=6&db=m The role of Sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24855208&form=6&db=m SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.3.1.286 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26049753&form=6&db=m Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.3.1.286 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26647771&form=6&db=m SIRT2 mediates multidrug resistance in acute myelogenous leukemia cells via ERK1/2 signaling pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.3.1.286 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27725192&form=6&db=m AML1-ETO promotes SIRT1 expression to enhance leukemogenesis of t(8;21) acute myeloid leukemia. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30081901&form=6&db=m Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31090265&form=6&db=m Role of SIRT1 in hematologic malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 2.3.1.286 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32037392&form=6&db=m Ginsenoside Rg1 Inhibits Cell Proliferation and Induces Markers of Cell Senescence in CD34+CD38- Leukemia Stem Cells Derived from KG1? Acute Myeloid Leukemia Cells by Activating the Sirtuin 1 (SIRT1)/Tuberous Sclerosis Complex 2 (TSC2) Signaling Pathway. diagnostic usage,ongoing research,unassigned 4,4,0 2.3.1.286 Leukemia-Lymphoma, Adult T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22322739&form=6&db=m High expression of the longevity gene product SIRT1, and apoptosis induction by sirtinol in adult T-cell leukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Lipid Metabolism Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29379801&form=6&db=m Quercetin Improves Glucose and Lipid Metabolism of Diabetic Rats: Involvement of Akt Signaling and SIRT1. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Lipoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Liposarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26379395&form=6&db=m MiR-9a-5p regulates proliferation and migration of hepatic stellate cells under pressure through inhibition of Sirt1. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26435214&form=6&db=m Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27871879&form=6&db=m Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30056271&form=6&db=m Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32393417&form=6&db=m Downregulation of p16 decreases biliary damage and liver fibrosis in the Mdr2-/- mouse model of primary sclerosing cholangitis. ongoing research,unassigned 4,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33230845&form=6&db=m SOD3 deficiency induces liver fibrosis by promoting hepatic stellate cell activation and epithelial-mesenchymal transition. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33935044&form=6&db=m Genome Edited Sirt1-Overexpressing Human Mesenchymal Stem Cells Exhibit Therapeutic Effects in Treating Collagen-Induced Arthritis. ongoing research,unassigned 4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18239056&form=6&db=m Involvement of mammalian sirtuin 1 in the action of ethanol in the liver. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20651844&form=6&db=m Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21103071&form=6&db=m Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21525818&form=6&db=m SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22934562&form=6&db=m Upregulation of Sirt1 in carbon-tetrachloride-induced acute liver injury. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25267960&form=6&db=m A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25358448&form=6&db=m Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients. diagnostic usage,ongoing research,unassigned 4,3,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26064858&form=6&db=m SIRT3 as a Regulator of Non-alcoholic Fatty Liver Disease. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26681077&form=6&db=m Sirtuin 1 modulation in rat model of acetaminophen-induced hepatotoxicity. therapeutic application,unassigned 4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26912655&form=6&db=m SIRT3 regulates ?-SMA production through the succinate dehydrogenase-GPR91 pathway in hepatic stellate cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27756894&form=6&db=m Altered microRNA-9 Expression Level is Directly Correlated with Pathogenesis of Nonalcoholic Fatty Liver Disease by Targeting Onecut2 and SIRT1. causal interaction,unassigned 4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29226969&form=6&db=m Cudratricusxanthone A attenuates sepsis-induced liver injury via SIRT1 signaling. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29310441&form=6&db=m Dihydromyricetin Ameliorates Nonalcoholic Fatty Liver Disease by Improving Mitochondrial Respiratory Capacity and Redox Homeostasis Through Modulation of SIRT3 Signaling. causal interaction,unassigned 4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30056271&form=6&db=m Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30785444&form=6&db=m Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32230804&form=6&db=m Low Expression of Sirtuin 1 in the Dairy Cows with Mild Fatty Liver Alters Hepatic Lipid Metabolism. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32485811&form=6&db=m Relevance of SIRT1-NF-?B Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease. therapeutic application,unassigned 4,0 2.3.1.286 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33098868&form=6&db=m miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload. ongoing research,unassigned 4,0 2.3.1.286 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26435214&form=6&db=m Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.286 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27871879&form=6&db=m Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22552445&form=6&db=m SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23024800&form=6&db=m SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27367026&form=6&db=m Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31608282&form=6&db=m SIRT1 in the Development and Treatment of Hepatocellular Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32562663&form=6&db=m Sirt3 promotes hepatocellular carcinoma cells sensitivity to regorafenib through the acceleration of mitochondrial dysfunction. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33401967&form=6&db=m miR-124-3p combined with miR-506-3p delay hepatic carcinogenesis via modulating sirtuin 1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34235106&form=6&db=m Inhibition of SIRT1 Limits Self-Renewal and Oncogenesis by Inducing Senescence of Liver Cancer Stem Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34457050&form=6&db=m miR-425 regulates lipophagy via SIRT1 to promote sorafenib resistance in liver cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22796566&form=6&db=m Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22799020&form=6&db=m [Sirtuin1 and lung disease]. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23542362&form=6&db=m Redox Regulation Of Sirt1 In Inflammation And Cellular Senescence. causal interaction,unassigned 4,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27888691&form=6&db=m Redox imbalance and mitochondrial abnormalities in the diabetic lung. causal interaction,unassigned 4,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28273432&form=6&db=m p53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28952835&form=6&db=m The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30014231&form=6&db=m Resolvin D1 Promotes SIRT1 Expression to Counteract the Activation of STAT3 and NF-?B in Mice with Septic-Associated Lung Injury. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30401412&form=6&db=m Niacin Pretreatment Attenuates Ischemia and Reperfusion of Pancreas-induced Acute Pancreatitis and Remote Lung Injury Through Suppressing Oxidative Stress and Inflammation and Activation of SIRT1. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30528955&form=6&db=m Arbutin attenuates LPS-induced lung injury via Sirt1/ Nrf2/ NF-?Bp65 pathway. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30626741&form=6&db=m SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16170353&form=6&db=m Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. ongoing research,unassigned 4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19017741&form=6&db=m Future treatments for chronic obstructive pulmonary disease and its comorbidities. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23702379&form=6&db=m Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23704280&form=6&db=m A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23915912&form=6&db=m Regulation of SIRT2 levels for human non-small cell lung cancer therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24223900&form=6&db=m SIRT1 expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24228097&form=6&db=m SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration. causal interaction,unassigned 4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25197348&form=6&db=m Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25719312&form=6&db=m SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2A. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25894374&form=6&db=m K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulation. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25915617&form=6&db=m Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26318035&form=6&db=m SIRT1 in B[a]P-induced lung tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26834854&form=6&db=m Association of SIRT1 and HMGA1 expression in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26903157&form=6&db=m [SIRT1 Influences the Sensitivity of A549 Non-small Cell Lung Cancer Cell Line to ?Cisplatin via Modulating the Noxa Expression]. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26942878&form=6&db=m SIRT2 inhibits non-small cell lung cancer cell growth through impairing Skp2-mediated p27 degradation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27768839&form=6&db=m Diagnostic investigation of BIRC6 and SIRT1 protein expression level as potential prognostic biomarkers in patients with non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28073696&form=6&db=m SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28197634&form=6&db=m SIRT3 is correlated with the malignancy of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28498463&form=6&db=m miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28869605&form=6&db=m Suppression of Sirt1 sensitizes lung cancer cells to WEE1 inhibitor MK-1775-induced DNA damage and apoptosis. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28919817&form=6&db=m SIRT1 gene polymorphisms and risk of lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28947845&form=6&db=m The Expression and Related Clinical Significance of SIRT3 in Non-Small-Cell Lung Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29103158&form=6&db=m SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29535539&form=6&db=m SIRT1 overexpression protects non-small cell lung cancer cells against osteopontin-induced epithelial-mesenchymal transition by suppressing NF-?B signaling. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29901178&form=6&db=m miR?150 promotes the proliferation and migration of non?small cell lung cancer cells by regulating the SIRT2/JMJD2A signaling pathway. causal interaction,unassigned 4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30058691&form=6&db=m Expression of SIRT1 gene in human lung cancer lines enhances their sensitivity to the anticancer effects of cisplatin. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30067423&form=6&db=m Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30779316&form=6&db=m Adjudin synergizes with paclitaxel and inhibits cell growth and metastasis by regulating the sirtuin 3-Forkhead box O3a axis in human small-cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31043584&form=6&db=m SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance in lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31760527&form=6&db=m RBM38 induces SIRT1 expression during hypoxia in non-small cell lung cancer cells by suppressing MIR34A expression. ongoing research,unassigned 4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31932479&form=6&db=m E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32267139&form=6&db=m Hsa-miR-217 Inhibits the Proliferation, Migration, and Invasion in Non-small Cell Lung Cancer Cells Via Targeting SIRT1 and P53/KAI1 Signaling causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32705247&form=6&db=m Sirtuin 7 promotes non?small cell lung cancer progression by facilitating G1/S phase and epithelial?mesenchymal transition and activating AKT and ERK1/2 signaling. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014852&form=6&db=m The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene? causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34405009&form=6&db=m Sirt3 Promoted DNA Damage Repair and Radioresistance Through ATM-Chk2 in Non-small Cell Lung Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34429771&form=6&db=m Emerging role of SIRT2 in non-small cell lung cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19509139&form=6&db=m Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21865267&form=6&db=m Expression of SIRT1 in Gastric Cardiac Cancer and Its Clinicopathologic Significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22661383&form=6&db=m Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23702379&form=6&db=m Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25105144&form=6&db=m The sirtuin 3 expression profile is associated with pathological and clinical outcomes in colon cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25785036&form=6&db=m Clinicopathological and prognostic role of SIRT1 in breast cancer patients: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26280894&form=6&db=m Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26515337&form=6&db=m SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26520143&form=6&db=m Over-expression of Sirt1 contributes to chemoresistance and indicates poor prognosis in serous epithelial ovarian cancer (EOC). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26585892&form=6&db=m Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26893713&form=6&db=m Expression and clinical significance of Sirt1 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27483432&form=6&db=m The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28947845&form=6&db=m The Expression and Related Clinical Significance of SIRT3 in Non-Small-Cell Lung Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29739048&form=6&db=m Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29896286&form=6&db=m SIRT1 promotes formation of breast cancer through modulating Akt activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30546451&form=6&db=m Expression of miR-204 in pediatric retinoblastoma and its effects on proliferation and apoptosis of cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930849&form=6&db=m Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32176025&form=6&db=m SIRT2 expression exhibits potential to serve as a biomarker for disease surveillance and prognosis in the management of cervical cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32697380&form=6&db=m SIRT2, a direct target of miR-212-5p, suppresses the proliferation and metastasis of colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.3.1.286 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33165440&form=6&db=m Effect of the SIRT3-AMPK/PPAR pathway on invasion and migration of cervical cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18724249&form=6&db=m SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25664004&form=6&db=m SIRT1 counteracted the activation of STAT3 and NF-?B to repress the gastric cancer growth. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.3.1.286 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26631723&form=6&db=m Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27124741&form=6&db=m Expression of the significance of silent information regulator type-1 in Angioimmunoblastic T-cell lymphoma is greater association with tumorigenesis and has strong implications for adverse prognosis. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30059665&form=6&db=m Modulating SIRT1 activity variously affects thymic lymphoma development in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18724249&form=6&db=m SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26280894&form=6&db=m Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29873178&form=6&db=m Alcohol-mediated miR-34a modulates hepatocyte growth and apoptosis. causal interaction,unassigned 4,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30546451&form=6&db=m Expression of miR-204 in pediatric retinoblastoma and its effects on proliferation and apoptosis of cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31227513&form=6&db=m B-cell Lymphomas Exhibit a Non-Oncogene Addiction to SIRT3. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32595528&form=6&db=m Xanomeline Protects Cortical Cells From Oxygen-Glucose Deprivation via Inhibiting Oxidative Stress and Apoptosis. diagnostic usage,ongoing research,unassigned 4,2,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33750511&form=6&db=m Aging-Related Functional and Structural Changes in Renal Tissues: Lesson from a Camel Model. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34146399&form=6&db=m Protective effects of ginsenoside Rc against acute cold exposure-induced myocardial injury in rats. diagnostic usage,ongoing research,unassigned 4,1,0 2.3.1.286 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34437278&form=6&db=m B-cell Lymphomas Exhibit a Non-Oncogene Addiction to SIRT3. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18724249&form=6&db=m SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Lymphoma, Mantle-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26631723&form=6&db=m Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Lymphoma, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24362520&form=6&db=m The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration. causal interaction,unassigned 4,0 2.3.1.286 Lymphoma, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27124741&form=6&db=m Expression of the significance of silent information regulator type-1 in Angioimmunoblastic T-cell lymphoma is greater association with tumorigenesis and has strong implications for adverse prognosis. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Lymphoma, T-Cell, Cutaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24343700&form=6&db=m SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis. causal interaction,unassigned 4,0 2.3.1.286 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22275802&form=6&db=m Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2?. ongoing research,unassigned 4,0 2.3.1.286 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23135526&form=6&db=m Expression of sirt1 in choroidal neovascular membranes. ongoing research,unassigned 4,0 2.3.1.286 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23892278&form=6&db=m The role of SIRT1 in ocular aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29693113&form=6&db=m Role of Sirtuin 1 in the pathogenesis of ocular disease (Review). causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33650806&form=6&db=m Reduced metabolic capacity in fast and slow skeletal muscle via oxidative stress and the energy-sensing of AMPK/SIRT1 in malnutrition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 2.3.1.286 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19907922&form=6&db=m p53 Regulates LIF expression in human medulloblastoma cells. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22537175&form=6&db=m Expression patterns and potential roles of SIRT1 in human medulloblastoma cells in vivo and in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24469059&form=6&db=m A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24480879&form=6&db=m SIRT1 Regulates Lamellipodium Extension and Migration of Melanoma Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24743044&form=6&db=m Novel downstream molecular targets of SIRT1 in melanoma: a quantitative proteomics approach. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24751483&form=6&db=m SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26743598&form=6&db=m Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27171429&form=6&db=m SIRT2 Expression Is Higher in Uveal Melanoma than In Ocular Melanocytes. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28882678&form=6&db=m RNA interference-mediated knockdown of SIRT1 and/or SIRT2 in melanoma: Identification of downstream targets by large-scale proteomics analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29234488&form=6&db=m SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33937086&form=6&db=m Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34068624&form=6&db=m Targeting SIRT2 Sensitizes Melanoma Cells to Cisplatin via an EGFR-Dependent Mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34155309&form=6&db=m SIRT2 promotes murine melanoma progression through natural killer cell inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19643082&form=6&db=m Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22542746&form=6&db=m Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression. ongoing research,unassigned 4,0 2.3.1.286 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25589773&form=6&db=m SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1?. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30484407&form=6&db=m Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer's Disease. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30794116&form=6&db=m Obesity caused by a high-fat diet regulates the Sirt1/PGC-1?/FNDC5/BDNF pathway to exacerbate isoflurane-induced postoperative cognitive dysfunction in older mice. therapeutic application,unassigned 4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17646659&form=6&db=m Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18336301&form=6&db=m Inhibitors of NAD+ dependent histone deacetylases (sirtuins). causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18774777&form=6&db=m SIRTUIN 1: regulating the regulator. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19260974&form=6&db=m Silent information regulator, Sirtuin 1, and age-related diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19996381&form=6&db=m SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20097879&form=6&db=m Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20185821&form=6&db=m A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition. causal interaction,unassigned 4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21331741&form=6&db=m Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,3 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21525818&form=6&db=m SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21549004&form=6&db=m Mammalian Sirt1: insights on its biological functions. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21813271&form=6&db=m Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22106091&form=6&db=m Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? therapeutic application,unassigned 4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22233091&form=6&db=m SIRT1: new avenues of discovery for disorders of oxidative stress. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23259556&form=6&db=m SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23374725&form=6&db=m Sirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism. therapeutic application,unassigned 4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23997790&form=6&db=m Sirtuin 3: A major control point for obesity-related metabolic diseases? therapeutic application,unassigned 4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26275361&form=6&db=m Pyrroloquinoline quinone increases the expression and activity of Sirt1 and -3 genes in HepG2 cells. therapeutic application,unassigned 4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26862948&form=6&db=m Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27000941&form=6&db=m SIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts Endothelial-Dependent Vasorelaxation in Mice and Human with Obesity. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27153347&form=6&db=m How much successful are the medicinal chemists in modulation of SIRT1: A critical review. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27164052&form=6&db=m The role of mitochondrial sirtuins in health and disease. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28664098&form=6&db=m Antagonistic crosstalk between SIRT1, PARP-1, and -2 in the regulation of chronic inflammation associated with aging and metabolic diseases. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28810642&form=6&db=m Overexpressed eNOS upregulates SIRT1 expression and protects mouse pancreatic ? cells from apoptosis. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30132870&form=6&db=m Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32140263&form=6&db=m SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32296036&form=6&db=m SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32724473&form=6&db=m Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17633479&form=6&db=m [Research progression of deacetylase (SIRT1)] causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18928399&form=6&db=m Opposite Effects of Metabolic Syndrome and Calorie Restriction on Thrombotic Disease: Head and Tail of Same Coin-Resveratrol's Role. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19455179&form=6&db=m SIRT1 and insulin resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20068143&form=6&db=m Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20601277&form=6&db=m Sirtuin activators: Designing molecules to extend life span. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22553202&form=6&db=m Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24370889&form=6&db=m Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24756314&form=6&db=m Myeloid-specific deletion of SIRT1 increases hepatic steatosis and hypothalamic inflammation in mice fed a high-fat diet. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25284742&form=6&db=m Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans. causal interaction,unassigned 4,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25358448&form=6&db=m Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients. diagnostic usage,ongoing research,unassigned 4,3,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25874615&form=6&db=m Tang-Nai-Kang alleviates pre-diabetes and metabolic disorders and induces a gene expression switch toward fatty acid oxidation in SHR.Cg-Leprcp/NDmcr rats. therapeutic application,unassigned 4,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26422395&form=6&db=m SIRT1 and insulin resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27362524&form=6&db=m Mitochondrial Sirtuin 3 and Renal Diseases. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27432859&form=6&db=m Vascular Smooth Muscle Sirtuin-1 Protects Against Diet-Induced Aortic Stiffness. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29712732&form=6&db=m Sirtuins in Renal Health and Disease. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30374331&form=6&db=m High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30510203&form=6&db=m SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain. causal interaction,unassigned 4,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31464387&form=6&db=m Mitochondrial Hyperacetylation in the Failing Hearts of Obese Patients Mediated Partly by a Reduction in SIRT3: The Involvement of the Mitochondrial Permeability Transition Pore. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32320732&form=6&db=m SIRT1 Regulation in Ageing and Obesity. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33324265&form=6&db=m Association Between SIRT1, Cytokines, and Metabolic Syndrome in Schizophrenia Patients With Olanzapine or Clozapine Monotherapy. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.286 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33371997&form=6&db=m Ketogenesis and SIRT1 as a tool in managing obesity. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Metabolism, Inborn Errors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27146436&form=6&db=m Sirtuin activation as a therapeutic approach against inborn errors of metabolism. therapeutic application,unassigned 4,0 2.3.1.286 methylenetetrahydrofolate dehydrogenase (nad+) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21169404&form=6&db=m Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1. causal interaction,unassigned 4,0 2.3.1.286 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33155431&form=6&db=m miR-34a-5p up-regulates the IL-1?/COX2/PGE2 inflammation pathway and induces the release of CGRP via inhibition of SIRT1 in rat trigeminal ganglion neurons. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33395186&form=6&db=m Upregulation of silent information regulator 1 alleviates mitochondrial dysfunction in the trigeminal nucleus caudalis in a rat model of chronic migraine. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Mitochondrial Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28387563&form=6&db=m Curcumin Upregulates Antioxidant Defense, Lon Protease, and Heat-Shock Protein 70 Under Hyperglycemic Conditions in Human Hepatoma Cells. ongoing research,unassigned 4,0 2.3.1.286 Motor Neuron Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24507186&form=6&db=m SIRT1 in neurodevelopment and brain senescence. causal interaction,unassigned 4,0 2.3.1.286 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23881456&form=6&db=m Growth Inhibition and Apoptosis-Inducing Effects of Cudraflavone B in Human Oral Cancer Cells via MAPK, NF-?B, and SIRT1 Signaling Pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31931863&form=6&db=m DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing-a possible predictive biomarker for malignant transformation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,2 2.3.1.286 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33570800&form=6&db=m The ambiguous role of sirtuins in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21950728&form=6&db=m Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells. causal interaction,unassigned 4,0 2.3.1.286 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24397908&form=6&db=m SIRT1 is decreased during relapses in patients with multiple sclerosis. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25918343&form=6&db=m SIRT1 deacetylates ROR?t and enhances Th17 cell generation. therapeutic application,unassigned 4,0 2.3.1.286 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28109694&form=6&db=m SIRT1 as a potential biomarker of response to treatment with glatiramer acetate in multiple sclerosis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29494741&form=6&db=m SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Multiple Sclerosis, Relapsing-Remitting http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24397908&form=6&db=m SIRT1 is decreased during relapses in patients with multiple sclerosis. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23689277&form=6&db=m Sirtuin deacetylases in neurodegenerative diseases of aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25389371&form=6&db=m Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65. causal interaction,unassigned 4,0 2.3.1.286 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34276308&form=6&db=m HDAC4 Knockdown Alleviates Denervation-Induced Muscle Atrophy by Inhibiting Myogenin-Dependent Atrogene Activation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25032964&form=6&db=m Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy. ongoing research,unassigned 4,0 2.3.1.286 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25032964&form=6&db=m Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy. ongoing research,unassigned 4,0 2.3.1.286 Mycobacterium Infections, Nontuberculous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32835604&form=6&db=m Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25195579&form=6&db=m Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics. therapeutic application,unassigned 4,0 2.3.1.286 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31090265&form=6&db=m Role of SIRT1 in hematologic malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23201684&form=6&db=m The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. therapeutic application,unassigned 4,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24535859&form=6&db=m Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25706717&form=6&db=m A TagSNP in SIRT1 Gene Confers Susceptibility to Myocardial Infarction in a Chinese Han Population. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26524632&form=6&db=m Preserved recovery of cardiac function following ischemia-reperfusion in mice lacking SIRT3. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27333745&form=6&db=m [SIRT1]. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28043667&form=6&db=m A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28302481&form=6&db=m Metformin improves cardiac function in mice with heart failure after myocardial infarction by regulating mitochondrial energy metabolism. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29444200&form=6&db=m Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30227330&form=6&db=m SIRT3-mediated cardiac remodeling/repair following myocardial infarction. causal interaction,unassigned 4,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30608184&form=6&db=m Sirt1 Antisense Long Noncoding RNA Promotes Cardiomyocyte Proliferation by Enhancing the Stability of Sirt1. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31291416&form=6&db=m Serum Sirtuin 1, 3 and 6 Levels in Acute Myocardial Infarction Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31858519&form=6&db=m Cardiomyocyte-Specific JunD Overexpression Increases Infarct Size following Ischemia/Reperfusion Cardiac Injury by Downregulating Sirt3. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23880291&form=6&db=m SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury. causal interaction,unassigned 4,0 2.3.1.286 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26122034&form=6&db=m SIRT1 as a promising novel therapeutic target for myocardial ischemia reperfusion injury and cardiometabolic disease. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27128560&form=6&db=m Ablation of SIRT3 causes coronary microvascular dysfunction and impairs cardiac recovery post myocardial ischemia. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28271186&form=6&db=m SUV39H1 mediated SIRT1 trans-repression contributes to cardiac ischemia-reperfusion injury. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29409011&form=6&db=m Cardiomyocyte Specific Deletion of Sirt1 Gene Sensitizes Myocardium to Ischemia and Reperfusion Injury. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Myocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31894309&form=6&db=m miR?217 and miR?543 downregulation mitigates inflammatory response and myocardial injury in children with viral myocarditis by regulating the SIRT1/AMPK/NF??B signaling pathway. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.286 nadh:ubiquinone reductase (h+-translocating) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23931755&form=6&db=m Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 nadh:ubiquinone reductase (h+-translocating) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27126960&form=6&db=m Resveratrol attenuates oxidative stress in mitochondrial Complex I deficiency: Involvement of SIRT3. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19260974&form=6&db=m Silent information regulator, Sirtuin 1, and age-related diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19509139&form=6&db=m Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21677689&form=6&db=m SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21920899&form=6&db=m SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor ? in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22470132&form=6&db=m SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22661383&form=6&db=m Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23348706&form=6&db=m SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition via akt/GSK-3?/?-catenin signaling (revised version). causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23702379&form=6&db=m Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23704280&form=6&db=m A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23843607&form=6&db=m PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24035280&form=6&db=m Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24228097&form=6&db=m SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration. causal interaction,unassigned 4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24278473&form=6&db=m SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24362520&form=6&db=m The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration. causal interaction,unassigned 4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24480879&form=6&db=m SIRT1 Regulates Lamellipodium Extension and Migration of Melanoma Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24816737&form=6&db=m Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24959282&form=6&db=m Sirt1 is a tumor promoter in lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25105144&form=6&db=m The sirtuin 3 expression profile is associated with pathological and clinical outcomes in colon cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25522783&form=6&db=m Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25785036&form=6&db=m Clinicopathological and prognostic role of SIRT1 in breast cancer patients: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25926383&form=6&db=m Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26004371&form=6&db=m Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26280894&form=6&db=m Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26515337&form=6&db=m SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26520143&form=6&db=m Over-expression of Sirt1 contributes to chemoresistance and indicates poor prognosis in serous epithelial ovarian cancer (EOC). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26585892&form=6&db=m Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26862948&form=6&db=m Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26893713&form=6&db=m Expression and clinical significance of Sirt1 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26936024&form=6&db=m Expression of Leptin and Sirtuin-1 is associated with poor prognosis in patients with osteosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26959057&form=6&db=m Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26975631&form=6&db=m SIRT1 promotes epithelial-mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27081083&form=6&db=m SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1?-mediated mitochondrial biogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27153347&form=6&db=m How much successful are the medicinal chemists in modulation of SIRT1: A critical review. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27166997&form=6&db=m miR-133b inhibits glioma cell proliferation and invasion by targeting Sirt1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27216459&form=6&db=m Down-regulation of SIRT3 promotes ovarian carcinoma metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,3 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27483432&form=6&db=m The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27793039&form=6&db=m SIRT1 promotes metastasis of human osteosarcoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28088387&form=6&db=m SIRT2 mediated antitumor effects of shikonin on metastatic colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28112277&form=6&db=m The expression of SIRT1 regulates the metastaticplasticity of chondrosarcoma cells by inducing epithelial-mesenchymal transition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28351313&form=6&db=m SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28498463&form=6&db=m miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28935184&form=6&db=m Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28947845&form=6&db=m The Expression and Related Clinical Significance of SIRT3 in Non-Small-Cell Lung Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29194618&form=6&db=m Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial-mesenchymal transition in cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29262808&form=6&db=m Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29656187&form=6&db=m SIRT1 expression regulates the transformation of resistant esophageal cancer cells via the epithelial-mesenchymal transition. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29695913&form=6&db=m Combination of SIRT1 and Src overexpression suggests poor prognosis in luminal breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29739048&form=6&db=m Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29752439&form=6&db=m A novel long non-coding RNA-PRLB acts as a tumor promoter through regulating miR-4766-5p/SIRT1 axis in breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29896286&form=6&db=m SIRT1 promotes formation of breast cancer through modulating Akt activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29915029&form=6&db=m Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30261494&form=6&db=m Role of SIRT2 in Regulation of Stemness of Cancer Stem-Like Cells in Renal Cell Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30380732&form=6&db=m Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30546451&form=6&db=m Expression of miR-204 in pediatric retinoblastoma and its effects on proliferation and apoptosis of cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30584257&form=6&db=m Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30710340&form=6&db=m SIRT1 inhibits gastric cancer proliferation and metastasis via STAT3/MMP-13 signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30779316&form=6&db=m Adjudin synergizes with paclitaxel and inhibits cell growth and metastasis by regulating the sirtuin 3-Forkhead box O3a axis in human small-cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930849&form=6&db=m Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930981&form=6&db=m Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31288899&form=6&db=m MicroRNA-1225-5p inhibits the development and progression of thyroid cancer via targeting sirtuin 3. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31341634&form=6&db=m A novel Ubc9 -dependent pathway regulates SIRT1- ER-? Axis and BRCA1-associated TNBC lung metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31608282&form=6&db=m SIRT1 in the Development and Treatment of Hepatocellular Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31957839&form=6&db=m Circ_0005075 stimulates the proliferation and metastasis of glioma via downregulating SIRT1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32176025&form=6&db=m SIRT2 expression exhibits potential to serve as a biomarker for disease surveillance and prognosis in the management of cervical cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32267139&form=6&db=m Hsa-miR-217 Inhibits the Proliferation, Migration, and Invasion in Non-small Cell Lung Cancer Cells Via Targeting SIRT1 and P53/KAI1 Signaling causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32361710&form=6&db=m Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32426286&form=6&db=m Sirtuin 1 Inhibiting Thiocyanates (S1th)-A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32607257&form=6&db=m Hepatocellular Expression of SIRT1 and Its Effect on Hepatocellular Carcinoma Progression: A Future Therapeutic Perspective. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32697380&form=6&db=m SIRT2, a direct target of miR-212-5p, suppresses the proliferation and metastasis of colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32714081&form=6&db=m HBx mediated Increase of SIRT1 Contributes to HBV-related Hepatocellular Carcinoma Tumorigenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33115805&form=6&db=m Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33165440&form=6&db=m Effect of the SIRT3-AMPK/PPAR pathway on invasion and migration of cervical cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33282964&form=6&db=m The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33344455&form=6&db=m Down Regulation of SIRT2 Reduced ASS Induced NSCLC Apoptosis Through the Release of Autophagy Components via Exosomes. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33649834&form=6&db=m SIRT1 and gynecological malignancies (Review). causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34163012&form=6&db=m SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12960381&form=6&db=m Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16170353&form=6&db=m Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. ongoing research,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16211212&form=6&db=m FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene, Sirtuin 2 (Sirt2). causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16546327&form=6&db=m SIRT1: tumor promoter or tumor suppressor? causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16596166&form=6&db=m Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17003781&form=6&db=m Altered sirtuin expression is associated with node-positive breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17180656&form=6&db=m Strong expression of a longevity-related protein, SIRT1, in Bowen's disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17334224&form=6&db=m SIRT1 promotes DNA repair activity and deacetylation of Ku70. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17620057&form=6&db=m Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17633479&form=6&db=m [Research progression of deacetylase (SIRT1)] causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17638871&form=6&db=m SIRT1 is significantly elevated in mouse and human prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18336301&form=6&db=m Inhibitors of NAD+ dependent histone deacetylases (sirtuins). causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18724249&form=6&db=m SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18774777&form=6&db=m SIRTUIN 1: regulating the regulator. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18835033&form=6&db=m Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18851829&form=6&db=m Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19060927&form=6&db=m Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19103747&form=6&db=m SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19166820&form=6&db=m Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19173036&form=6&db=m SIRT1, is it a tumor promoter or tumor suppressor? causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19244112&form=6&db=m The critical role of the class III histone deacetylase SIRT1 in cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19260974&form=6&db=m Silent information regulator, Sirtuin 1, and age-related diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19285066&form=6&db=m Resveratrol inhibits proliferation and promotes apoptosis of osteosarcoma cells. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19404850&form=6&db=m Expression and prognostic significance of SIRT1 in ovarian epithelial tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19430421&form=6&db=m SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19433578&form=6&db=m SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19439501&form=6&db=m SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age-related neoplasms. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19509139&form=6&db=m Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19595309&form=6&db=m Sirtuins and p53. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19725468&form=6&db=m Role of prosurvival molecules in the action of lidamycin toward human tumor cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19928762&form=6&db=m Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20129243&form=6&db=m A tumor suppressor SIRTainty. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20178071&form=6&db=m SIRT1 Inhibitory Diterpenoids from the Vietnamese Medicinal Plant Croton tonkinensis. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20185821&form=6&db=m A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20370686&form=6&db=m Reactivation of p53 by Novel MDM2 Inhibitors: Implications for Pancreatic Cancer Therapy. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20412117&form=6&db=m Balance between SIRT1 and DBC1 expression is lost in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20471503&form=6&db=m SIRT1 and p53, effect on cancer, senescence and beyond. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20606733&form=6&db=m Over-expression of nicotinamide phosphoribosyltransferase in ovarian cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20815175&form=6&db=m [Sirtuins--modulation of their activity as a novel therapeutic target]. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21056897&form=6&db=m Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21149730&form=6&db=m Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21195657&form=6&db=m Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21307403&form=6&db=m SirT1 brings stemness closer to cancer and aging. therapeutic application,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21397863&form=6&db=m SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1? Destabilization. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21414717&form=6&db=m Sirtuin 1 in malignant transformation: Friend or foe? causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21520490&form=6&db=m Resveratrol (trans-3,5,4'-trihydroxystilbene) suppresses EL4 tumor growth by induction of apoptosis involving reciprocal regulation of SIRT1 and NF-?B. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21549004&form=6&db=m Mammalian Sirt1: insights on its biological functions. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21567102&form=6&db=m Expression and role of SIRT1 in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21586315&form=6&db=m SIRT3 and cancer: tumor promoter or suppressor? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21596753&form=6&db=m miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21677689&form=6&db=m SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21742641&form=6&db=m SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21865267&form=6&db=m Expression of SIRT1 in Gastric Cardiac Cancer and Its Clinicopathologic Significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21890154&form=6&db=m A multicancer-like syndrome in a dog characterized by p53 and cell cycle-checkpoint kinase 2 (CHK2) mutations and Sirtuin gene (SIRT1) down-regulation. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21905824&form=6&db=m Effect of resveratrol derivative BTM-0512 on high glucose-induced dysfunction of endothelial cells: role of SIRT1. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21920899&form=6&db=m SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor ? in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22014574&form=6&db=m SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22016654&form=6&db=m Sirt3, Mitochondrial ROS, Ageing, and Carcinogenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22121876&form=6&db=m Small-molecule chromatin-modifying agents: therapeutic applications. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22146883&form=6&db=m SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22159506&form=6&db=m SIRTUIN (SIRT) 1 AND STEROID HORMONE RECEPTOR ACTIVITY IN CANCER. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22180829&form=6&db=m The role of SIRT1 in tumorigenesis. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22203920&form=6&db=m Translating cell survival and cell longevity into treatment strategies with SIRT1. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22302044&form=6&db=m SirT1 confers hypoxia-induced radioresistance via the modulation of c-Myc stabilization on hepatoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22319497&form=6&db=m Sirtuins and disease: the road ahead. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22330808&form=6&db=m SIRT1 overexpression decreases cisplatin-induced acetylation of NF-?B p65 subunit and cytotoxicity in renal proximal tubule cells. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22333659&form=6&db=m Expression of SIRT1 in Ocular Surface Squamous Neoplasia. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22470132&form=6&db=m SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22483777&form=6&db=m Amurensin G, a novel SIRT1 inhibitor, sensitizes TRAIL-resistant human leukemic K562 cells to TRAIL-induced apoptosis. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22552445&form=6&db=m SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22563317&form=6&db=m SIRT2 as a Therapeutic Target for Age-Related Disorders. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22661383&form=6&db=m Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22704201&form=6&db=m The sirtuins in the pathogenesis of cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22730114&form=6&db=m Sirtuin activators and inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22796566&form=6&db=m Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22885181&form=6&db=m Genetic analysis of the SIRT1 gene promoter in ventricular septal defects. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22929231&form=6&db=m Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: Their evaluation as inhibitors of SIRT1. ongoing research,therapeutic application,unassigned 1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22931526&form=6&db=m Benzodeazaoxaflavins as Sirtuin Inhibitors with Antiproliferative Properties in Cancer Stem Cells. therapeutic application,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22943040&form=6&db=m SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22944623&form=6&db=m Cortactin is associated with tumour progression and poor prognosis in prostate cancer and SIRT2 other than HADC6 may work as facilitator in situ. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22977628&form=6&db=m Expression of DBC1 is associated with nuclear grade and HER2 expression in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22986535&form=6&db=m SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22998567&form=6&db=m Current advances in the synthesis and antitumoral activity of SIRT1-2 inhibitors by modulation of p53 and pro-apoptotic proteins. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23016857&form=6&db=m Rejuvenating sirtuins: the rise of a new family of cancer drug targets. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23024800&form=6&db=m SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23038275&form=6&db=m SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23175188&form=6&db=m The histone deacetylase SIRT2 stabilizes Myc oncoproteins. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23248098&form=6&db=m Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23255128&form=6&db=m Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23322738&form=6&db=m Tenovin-D3, a Novel Small-Molecule Inhibitor of Sirtuin SirT2, Increases p21 (CDKN1A) Expression in a p53-Independent Manner. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23339189&form=6&db=m Antitumor Effect of SIRT1 Inhibition in Human HCC Tumor Models In Vitro and In Vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23340254&form=6&db=m SIRT1 Positively Regulates Breast Cancer Associated Human Aromatase (CYP19A1) Expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23348706&form=6&db=m SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition via akt/GSK-3?/?-catenin signaling (revised version). causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23370328&form=6&db=m Sirtuin-1 Regulates Acinar-to-Ductal Metaplasia and Supports Cancer Cell Viability in Pancreatic Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23429453&form=6&db=m Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23453030&form=6&db=m SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23673452&form=6&db=m SIRT1 suppresses breast cancer growth through downregulation of the Bcl-2 protein. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23681230&form=6&db=m SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-?B/STAT3 complex to its promoter in malignant lymphoid cells. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23689277&form=6&db=m Sirtuin deacetylases in neurodegenerative diseases of aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23702379&form=6&db=m Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23723075&form=6&db=m HDAC6 and SIRT2 Regulate the Acetylation State and Oncogenic Activity of Mutant K-RAS. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23799088&form=6&db=m Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23805287&form=6&db=m The Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23842789&form=6&db=m Sirt3 is a tumor suppressor in lung adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23843607&form=6&db=m PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23856293&form=6&db=m Identification of Sirtuin 3, a mitochondrial protein deacetylase, as a new contributor to tamoxifen resistance in breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23859614&form=6&db=m A Dual Role for Sirtuin 1 in Tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23898059&form=6&db=m Nicotinamide phosphoribosyltransferase and SIRT3 expression are increased in well-differentiated thyroid carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23898190&form=6&db=m SIRT2 directs the replication stress response through CDK9 deacetylation. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23915912&form=6&db=m Regulation of SIRT2 levels for human non-small cell lung cancer therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24019998&form=6&db=m Emerging Roles of SIRT1 in Cancer Drug Resistance. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24020000&form=6&db=m The Roles of SIRT1 in Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24020004&form=6&db=m SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24020008&form=6&db=m Stress Inducibility of SIRT1 and Its Role in Cytoprotection and Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24035280&form=6&db=m Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24278473&form=6&db=m SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24287180&form=6&db=m Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24324009&form=6&db=m SirT3 regulates the mitochondrial unfolded protein response. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24351289&form=6&db=m SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF-1?-dependent glycolysis. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24362520&form=6&db=m The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24368766&form=6&db=m SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24438005&form=6&db=m Mammalian SIRT2 inhibits keratin 19 expression and is a tumor suppressor in skin. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24446434&form=6&db=m Sirt2 deacetylase is a novel AKT binding partner critical for AKT activation by insulin. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24448804&form=6&db=m SOD2 to SOD1 switch in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24486017&form=6&db=m Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24503539&form=6&db=m Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24573134&form=6&db=m Interferon ? protects against lethal endotoxic and septic shock through SIRT1 upregulation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24712640&form=6&db=m SIRT2 knockdown increases basal autophagy and prevents post-slippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24746213&form=6&db=m Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24751483&form=6&db=m SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24814870&form=6&db=m SIRT2 as a new player in epigenetic programming of keratinocyte differentiation and a candidate tumor suppressor. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24816737&form=6&db=m Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24832395&form=6&db=m Repression of SIRT1 promotes the differentiation of mouse induced pluripotent stem cells into neural stem cells. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24855208&form=6&db=m SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24909164&form=6&db=m SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24955214&form=6&db=m SOD1, an unexpected novel target for cancer therapy. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24959282&form=6&db=m Sirt1 is a tumor promoter in lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24962284&form=6&db=m Sirtuin inhibitors as anticancer agents. therapeutic application,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25033286&form=6&db=m Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25085245&form=6&db=m The SIRT1/HIF2? axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy. therapeutic application,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25096191&form=6&db=m SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of "cancer cells with neural stemness" in a p53-dependent manner. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25105144&form=6&db=m The sirtuin 3 expression profile is associated with pathological and clinical outcomes in colon cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25131770&form=6&db=m SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25146318&form=6&db=m SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25189993&form=6&db=m Identification of a novel polyprenylated acylphloroglucinol?derived SIRT1 inhibitor with cancer?specific anti-proliferative and invasion-suppressing activities. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25195579&form=6&db=m Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics. therapeutic application,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25267960&form=6&db=m A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25270091&form=6&db=m SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25280212&form=6&db=m A knockout Combo: eradicating AML Stem Cells with TKI plus SIRT1 inhibition. therapeutic application,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25281835&form=6&db=m Arsenic exposure disrupts epigenetic regulation of SIRT1 in human keratinocytes. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25383691&form=6&db=m Chroman-4-one- and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25483038&form=6&db=m Comprehensive silencing of target-sharing microRNAs is a mechanism for SIRT1 overexpression in cancer. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25500546&form=6&db=m High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25515955&form=6&db=m Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton. ongoing research,therapeutic application,unassigned 1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25516717&form=6&db=m SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25522783&form=6&db=m Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25529796&form=6&db=m Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25569080&form=6&db=m Diverse roles of SIRT1 in cancer biology and lipid metabolism. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25665637&form=6&db=m The relationship of SIRT3 with cellular metabolism and cardiovascular diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25696003&form=6&db=m Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25719312&form=6&db=m SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2A. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25732823&form=6&db=m DBC1 Functions as a Tumor Suppressor by Regulating p53 Stability. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25755250&form=6&db=m SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25798752&form=6&db=m SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25843411&form=6&db=m SIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25894374&form=6&db=m K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulation. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25915617&form=6&db=m Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25915842&form=6&db=m Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3?/BCL2-associated X protein-dependent apoptotic pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25926383&form=6&db=m Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25946975&form=6&db=m Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25995644&form=6&db=m SIRT1 expression is associated with poor prognosis of lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26004371&form=6&db=m Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26111688&form=6&db=m [Feasibility of integrating tumor therapy with therapeutic effect evaluation using siRNA-loaded microbubbles]. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26121130&form=6&db=m SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26131100&form=6&db=m SIRT3 inhibits cell proliferation in human gastric cancer through down-regulation of Notch-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26141949&form=6&db=m CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26183563&form=6&db=m Putative tumor suppression function of SIRT6 in endometrial cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26225773&form=6&db=m SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26280894&form=6&db=m Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26282546&form=6&db=m Emerging Drug Target In Pancreatic Cancer: Placing Sirtuin 1 on the Canvas. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26317998&form=6&db=m SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26367491&form=6&db=m Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26515337&form=6&db=m SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26585892&form=6&db=m Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26631723&form=6&db=m Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26636371&form=6&db=m Energy-Based Pharmacophore and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling Combined with Virtual Screening To Identify Novel Small-Molecule Inhibitors of Silent Mating-Type Information Regulation 2 Homologue 1 (SIRT1). causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26662958&form=6&db=m Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26775341&form=6&db=m Decreased expression of SIRT6 promotes tumor cell growth correlates closely with poor prognosis of ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26834854&form=6&db=m Association of SIRT1 and HMGA1 expression in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26862948&form=6&db=m Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26893713&form=6&db=m Expression and clinical significance of Sirt1 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26902145&form=6&db=m BRCA1 inhibits AR-mediated proliferation of breast cancer cells through the activation of SIRT1. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26903157&form=6&db=m [SIRT1 Influences the Sensitivity of A549 Non-small Cell Lung Cancer Cell Line to ?Cisplatin via Modulating the Noxa Expression]. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26934204&form=6&db=m Cyanidin 3-O-?-Glucoside Ameliorates Ethanol-Induced Acute Liver Injury by Attenuating Oxidative Stress and Apoptosis: The Role of SIRT1/FOXO1 Signaling. diagnostic usage,ongoing research,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26935174&form=6&db=m MnSOD acetylation and dys-regulation, due to loss of SIRT3 activity, promotes a Luminal B-like breast carcinogenic permissive phenotype. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26942878&form=6&db=m SIRT2 inhibits non-small cell lung cancer cell growth through impairing Skp2-mediated p27 degradation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26959057&form=6&db=m Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26975631&form=6&db=m SIRT1 promotes epithelial-mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26999517&form=6&db=m Association between SIRT1 Gene Polymorphisms and Breast Cancer in Egyptians. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27080717&form=6&db=m High-throughput screening of Sirtuin family of genes in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27081083&form=6&db=m SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1?-mediated mitochondrial biogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27124741&form=6&db=m Expression of the significance of silent information regulator type-1 in Angioimmunoblastic T-cell lymphoma is greater association with tumorigenesis and has strong implications for adverse prognosis. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27164052&form=6&db=m The role of mitochondrial sirtuins in health and disease. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27171429&form=6&db=m SIRT2 Expression Is Higher in Uveal Melanoma than In Ocular Melanocytes. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27216459&form=6&db=m Down-regulation of SIRT3 promotes ovarian carcinoma metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27358235&form=6&db=m Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27362524&form=6&db=m Mitochondrial Sirtuin 3 and Renal Diseases. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27367026&form=6&db=m Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27384990&form=6&db=m SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27423864&form=6&db=m Synthesis and Assay of SIRT1-Activating Compounds. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27483432&form=6&db=m The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27514448&form=6&db=m SIRT1 controls cell proliferation by regulating contact inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27608947&form=6&db=m NAMPT inhibition synergizes with NQO1-targeting agents in inducing apoptotic cell death in non-small cell lung cancer cells. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27686535&form=6&db=m Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27725192&form=6&db=m AML1-ETO promotes SIRT1 expression to enhance leukemogenesis of t(8;21) acute myeloid leukemia. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27725455&form=6&db=m Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27763686&form=6&db=m Melatonin and the pathologies of weakened or dysregulated circadian oscillators. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27764779&form=6&db=m Mesenchymal stem cells overexpressing Sirt1 inhibit prostate cancer growth by recruiting natural killer cells and macrophages. ongoing research,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27768839&form=6&db=m Diagnostic investigation of BIRC6 and SIRT1 protein expression level as potential prognostic biomarkers in patients with non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27793039&form=6&db=m SIRT1 promotes metastasis of human osteosarcoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27840909&form=6&db=m Sirtuin 3: A Janus face in cancer (Review). causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28073696&form=6&db=m SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28088387&form=6&db=m SIRT2 mediated antitumor effects of shikonin on metastatic colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28112277&form=6&db=m The expression of SIRT1 regulates the metastaticplasticity of chondrosarcoma cells by inducing epithelial-mesenchymal transition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28197634&form=6&db=m SIRT3 is correlated with the malignancy of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28299833&form=6&db=m Unsupervised pharmacophore modeling combined with QSAR analyses revealed novel low micromolar SIRT2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28351313&form=6&db=m SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28415012&form=6&db=m Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors. therapeutic application,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28423723&form=6&db=m Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28461331&form=6&db=m Sirtuin 2 mutations in human cancers impair its function in genome maintenance. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28498463&form=6&db=m miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28514749&form=6&db=m A variant in SIRT2 gene 3'-UTR is associated with susceptibility to colorectal cancer. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28526414&form=6&db=m A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28648037&form=6&db=m [Effects of activating silent information regulator 1 on early kidney damage in rats with severe burn]. diagnostic usage,ongoing research,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28656307&form=6&db=m SIRT6 inhibits growth of gastric cancer by inhibiting JAK2/STAT3 pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28667895&form=6&db=m SIRT1 Regulates the Chemoresistance and Invasiveness of Ovarian Carcinoma Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28755171&form=6&db=m SIRT1 induces resistance to apoptosis in human granulosa cells by activating the ERK pathway and inhibiting NF-?B signaling with anti-inflammatory functions. diagnostic usage,ongoing research,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28867266&form=6&db=m Low SIRT3 expression contributes to tumor progression, development and poor prognosis in human pancreatic carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28878214&form=6&db=m Hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating SIRT1 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28935184&form=6&db=m Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28947845&form=6&db=m The Expression and Related Clinical Significance of SIRT3 in Non-Small-Cell Lung Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29029516&form=6&db=m The prognostic role of Sirt1 expression in solid malignancies: a meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29050728&form=6&db=m SIRT1 acts as a potential tumor suppressor in oral squamous cell carcinoma. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29103158&form=6&db=m SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29124170&form=6&db=m The histone deacetylase inhibitor cambinol prevents acidic pH ongoing research,therapeutic application,unassigned 1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29150734&form=6&db=m The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29194618&form=6&db=m Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial-mesenchymal transition in cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29207181&form=6&db=m Function of miR-212 as a tumor suppressor in thyroid cancer by targeting SIRT1. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29231244&form=6&db=m SIRT7 depletion inhibits cell proliferation, migration, and increases drug sensitivity by activating p38MAPK in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29262808&form=6&db=m Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29263907&form=6&db=m Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation. therapeutic application,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29340027&form=6&db=m Dual SIRT1 expression patterns strongly suggests its bivalent role in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29401749&form=6&db=m The Fungal Metabolite Eurochevalierine, a Sequiterpene Alkaloid, Displays Anti-Cancer Properties through Selective Sirtuin 1/2 Inhibition. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29416748&form=6&db=m SIRT1 contributes to neuroendocrine differentiation of prostate cancer. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29446717&form=6&db=m Activators of Sirtuin-1 and their Involvement in Cardioprotection. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29535539&form=6&db=m SIRT1 overexpression protects non-small cell lung cancer cells against osteopontin-induced epithelial-mesenchymal transition by suppressing NF-?B signaling. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29574020&form=6&db=m SIRT1 and microRNAs: The role in breast, lung and prostate cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29599352&form=6&db=m KDM4D Predicts Recurrence in Exocrine Pancreatic Cells of Resection Margins from Patients with Pancreatic Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29636061&form=6&db=m SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29650970&form=6&db=m Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29653746&form=6&db=m SRT1720, a potential sensitizer for radiotherapy and cytotoxicity effects of NVB-BEZ235 in metastatic breast cancer cells. ongoing research,therapeutic application,unassigned 1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29656187&form=6&db=m SIRT1 expression regulates the transformation of resistant esophageal cancer cells via the epithelial-mesenchymal transition. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29685974&form=6&db=m Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29693338&form=6&db=m Sirt1 Gene Expression and Gastric Epithelial Cells Tumor Stage in Patients with Helicobacter pylori Infection causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29694959&form=6&db=m Prognostic Impact of DNA Repair Protein Expression in Non-Small Cell Lung Cancers Treated with Platinum-Based Chemotherapy and Subsequent Curative Lung Resection. diagnostic usage,ongoing research,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29695913&form=6&db=m Combination of SIRT1 and Src overexpression suggests poor prognosis in luminal breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29712732&form=6&db=m Sirtuins in Renal Health and Disease. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29739048&form=6&db=m Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29808798&form=6&db=m Knockdown of SIRT1 inhibits proliferation and promotes apoptosis of paclitaxel-resistant human cervical cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29896286&form=6&db=m SIRT1 promotes formation of breast cancer through modulating Akt activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29908203&form=6&db=m SIRT2 reduces actin polymerization and cell migration through deacetylation and degradation of HSP90. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29915029&form=6&db=m Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29991742&form=6&db=m A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30008852&form=6&db=m Knockout of SIRT4 decreases chemosensitivity to 5-FU in colorectal cancer cells. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30058691&form=6&db=m Expression of SIRT1 gene in human lung cancer lines enhances their sensitivity to the anticancer effects of cisplatin. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30059665&form=6&db=m Modulating SIRT1 activity variously affects thymic lymphoma development in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30067423&form=6&db=m Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30081901&form=6&db=m Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30095923&form=6&db=m SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30148908&form=6&db=m [Combating tumor cells through SIRT3 activation and exercise]. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30250025&form=6&db=m Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells. ongoing research,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30258927&form=6&db=m Effect of Sirtuin 1 inhibition on matrix metalloproteinase 2 and Forkhead box O3a expression in breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30261494&form=6&db=m Role of SIRT2 in Regulation of Stemness of Cancer Stem-Like Cells in Renal Cell Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30304565&form=6&db=m SIRT1-ZEB1-positive feedback promotes epithelial-mesenchymal transition process and metastasis of osteosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30367032&form=6&db=m Oncogenic potential of BEX4 is conferred by Polo-like kinase 1-mediated phosphorylation. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30374331&form=6&db=m High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30377100&form=6&db=m [Dexmedetomidine alleviates postoperative cognitive dysfunction in aged rats probably via silent information regulator 1 pathway]. diagnostic usage,ongoing research,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30380732&form=6&db=m Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30405152&form=6&db=m Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30448921&form=6&db=m Probing the mechanism of SIRT1 activation by a 1,4-dihydropyridine. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30464504&form=6&db=m Sirt3 enhances glioma cell viability by stabilizing Ku70-BAX interaction. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30482390&form=6&db=m Stabilization of P/CAF, as a ubiquitin ligase toward MDM2, suppresses mitotic cell death through p53-p21 activation in HCT116?cells with SIRT2 suppression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30554563&form=6&db=m Reduced Plasma Kallistatin Is Associated With the Severity of Coronary Artery Disease, and Kallistatin Treatment Attenuates Atherosclerotic Plaque Formation in Mice. ongoing research,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30584257&form=6&db=m Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30620711&form=6&db=m The effect of adipocyte-macrophage cross-talk in obesity-related breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655890&form=6&db=m SIRT6 inhibits proliferation and invasion in osteosarcoma cells by targeting N-cadherin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30656603&form=6&db=m Sirtuin 3 inhibition induces mitochondrial stress in tongue cancer by targeting mitochondrial fission and the JNK-Fis1 biological axis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30671172&form=6&db=m Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30710340&form=6&db=m SIRT1 inhibits gastric cancer proliferation and metastasis via STAT3/MMP-13 signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30734528&form=6&db=m A Small-Molecule SIRT2 Inhibitor That Promotes K-Ras4a Lysine Fatty-Acylation. therapeutic application,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30756332&form=6&db=m Sirt1 antisense transcript is down-regulated in human tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30789810&form=6&db=m QSAR studies on the human sirtuin 2 inhibition by non-covalent 7,5,2-anilinobenzamide derivatives. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30826489&form=6&db=m The Contrary Effects of Sirt1 on MCF7 Cells Depend on CD36 Expression Level. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30837601&form=6&db=m Molecular imaging HDACs class IIa expression-activity and pharmacologic inhibition in intracerebral glioma models in rats using PET/CT/(MRI) with [18F]TFAHA. therapeutic application,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30842143&form=6&db=m SIRT1 Expression Is Associated With Cell Proliferation in Angiosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30868406&form=6&db=m SIRT1 promotes GLUT1 expression and bladder cancer progression via regulation of glucose uptake. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30897756&form=6&db=m Neuroprotective Effects of Ginsenosides against Cerebral Ischemia. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30902968&form=6&db=m Deacetylation of CHK2 by SIRT1 protects cells from oxidative stress-dependent DNA damage response. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930849&form=6&db=m Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930981&form=6&db=m Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30945643&form=6&db=m Upregulation of SIRT1 gene in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31043584&form=6&db=m SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance in lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31055111&form=6&db=m MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31056963&form=6&db=m SIRT1: a potential tumour biomarker and therapeutic target. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31074370&form=6&db=m Recent Progress on the Discovery of Sirt2 Inhibitors for the Treatment of Various Cancers. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31090265&form=6&db=m Role of SIRT1 in hematologic malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31092575&form=6&db=m SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to Vesicular Stomatitis Virus Oncolysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31108370&form=6&db=m SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31175839&form=6&db=m Pharmacological Targets and the Biological Mechanisms of Formononetin for Alzheimer's Disease: A Network Analysis. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31185214&form=6&db=m Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31209362&form=6&db=m SIRT1 modulates cell cycle progression by regulating CHK2 acetylation-phosphorylation. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31227513&form=6&db=m B-cell Lymphomas Exhibit a Non-Oncogene Addiction to SIRT3. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31247208&form=6&db=m ABT737 enhances ovarian cancer cells sensitivity to cisplatin through regulation of mitochondrial fission via Sirt3 activation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31251117&form=6&db=m The sirtuin family in cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31257493&form=6&db=m SIRT6 regulates the proliferation and apoptosis of hepatocellular carcinoma via the ERK1/2 signaling pathway. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31273630&form=6&db=m Altered Expression of CD44, SIRT1, CXCR4, miR-21, miR-34a, and miR-451 Genes in MKN-45 Cell Line After Docetaxel Treatment. ongoing research,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31288899&form=6&db=m MicroRNA-1225-5p inhibits the development and progression of thyroid cancer via targeting sirtuin 3. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31317367&form=6&db=m Cytoplasmic SIRT1 inhibits cell migration and invasion by impeding epithelial-mesenchymal transition in ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31505260&form=6&db=m SIRT2: Controversy and multiple roles in disease and physiology. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31684999&form=6&db=m ADC correlation with Sirtuin1 to assess early chemoradiotherapy response of locally advanced esophageal carcinoma patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31711765&form=6&db=m Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31765940&form=6&db=m Targeting histone deacetylase SIRT1 selectively eradicates EGFR TKI-resistant cancer stem cells via regulation of mitochondrial oxidative phosphorylation in lung adenocarcinoma. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31848116&form=6&db=m A scaffold replacement approach towards new sirtuin 2 inhibitors. ongoing research,therapeutic application,unassigned 1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31932479&form=6&db=m E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32098999&form=6&db=m Investigation of sirtuin 1 polymorphisms in relation to the risk of colorectal cancer by molecular subtype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32118205&form=6&db=m Noninvasive quantification of SIRT1 expression-activity and pharmacologic inhibition in a rat model of intracerebral glioma using 2-[18F]BzAHA PET/CT/MRI. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32158616&form=6&db=m SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3? activity in neuroblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32176025&form=6&db=m SIRT2 expression exhibits potential to serve as a biomarker for disease surveillance and prognosis in the management of cervical cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32256823&form=6&db=m Associations of sirtuins with clinicopathological variables and prognosis in human ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32320732&form=6&db=m SIRT1 Regulation in Ageing and Obesity. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32361710&form=6&db=m Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32388637&form=6&db=m Sirtuin1 expression and survival in endometrial and clear-cell uterine cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32393998&form=6&db=m Expression of immune checkpoints and T cell exhaustion markers in early and advanced stages of colorectal cancer. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32426286&form=6&db=m Sirtuin 1 Inhibiting Thiocyanates (S1th)-A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32447861&form=6&db=m [Mechanisms of electroacupuncture for improving Alzheimer's disease from reducing ? amyloid protein level]. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32449165&form=6&db=m The role of SIRT2 in cancer: A novel therapeutic target. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32538772&form=6&db=m Construction of SIRT1 gene shRNA lentivirus vector and its effect on the proliferation of breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32549218&form=6&db=m Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32558516&form=6&db=m [Coronavirus disease (COVID-19) and sirtuins]. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32562663&form=6&db=m Sirt3 promotes hepatocellular carcinoma cells sensitivity to regorafenib through the acceleration of mitochondrial dysfunction. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32607257&form=6&db=m Hepatocellular Expression of SIRT1 and Its Effect on Hepatocellular Carcinoma Progression: A Future Therapeutic Perspective. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32697380&form=6&db=m SIRT2, a direct target of miR-212-5p, suppresses the proliferation and metastasis of colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32705247&form=6&db=m Sirtuin 7 promotes non?small cell lung cancer progression by facilitating G1/S phase and epithelial?mesenchymal transition and activating AKT and ERK1/2 signaling. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32710757&form=6&db=m Sirtuin activation targets IDH-mutant tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32724473&form=6&db=m Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32761762&form=6&db=m CSAG2 is a cancer-specific activator of SIRT1. causal interaction,diagnostic usage,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32823525&form=6&db=m Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32863939&form=6&db=m Loss of SIRT4 promotes the self-renewal of Breast Cancer Stem Cells. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32898647&form=6&db=m Advances in characterization of SIRT3 deacetylation targets in mitochondrial function. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014276&form=6&db=m The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014852&form=6&db=m The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene? causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33061819&form=6&db=m The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33093847&form=6&db=m Lysine Acetylome Study of Human Hepatocellular Carcinoma Tissues for Biomarkers and Therapeutic Targets Discovery. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33115805&form=6&db=m Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33165440&form=6&db=m Effect of the SIRT3-AMPK/PPAR pathway on invasion and migration of cervical cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33231084&form=6&db=m PGC-1? activates SIRT3 to modulate cell proliferation and glycolytic metabolism in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33269110&form=6&db=m The Critical Role of SIRT1 in Parkinson's Disease: Mechanism and Therapeutic Considerations. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33324265&form=6&db=m Association Between SIRT1, Cytokines, and Metabolic Syndrome in Schizophrenia Patients With Olanzapine or Clozapine Monotherapy. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33363940&form=6&db=m Overlapping tumor-specific expression of p53, p16INK4a, and sirtuin 1 in Bowen's disease: A case report. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33368409&form=6&db=m Ethanol Exposure Attenuates Immune Response in Sepsis via Sirtuin 2 Expression. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33379119&form=6&db=m Deacetylation-activated construction of single quantum dot-based nanosensor for sirtuin 1 assay. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33401967&form=6&db=m miR-124-3p combined with miR-506-3p delay hepatic carcinogenesis via modulating sirtuin 1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33570800&form=6&db=m The ambiguous role of sirtuins in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33616302&form=6&db=m Overexpression of sirtuin 2 and its association with prognosis in acute ischemic stroke patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33617947&form=6&db=m Androgen deprivation-induced elevated nuclear SIRT1 promotes prostate tumor cell survival by reactivation of AR signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33649834&form=6&db=m SIRT1 and gynecological malignancies (Review). causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33705642&form=6&db=m The study of sirtuins in breast cancer patients before and after radiotherapy causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33860286&form=6&db=m A Provocative Molecular Link between Mammographic Density and BRCA1-loss associated TNBC. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33876629&form=6&db=m Discovery of Dihydro-1,4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin-1. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33930006&form=6&db=m Genomics of aging: The role of sirtuin and metabolic health. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33931611&form=6&db=m Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33937086&form=6&db=m Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33978360&form=6&db=m Sirtuin1 and Chronic Myeloid Leukemia: a Comprehensive Glance at Drug Resistance. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34094839&form=6&db=m Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators. therapeutic application,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34099590&form=6&db=m Myeloid-specific SIRT1 deletion exacerbates airway inflammatory response in a mouse model of allergic asthma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34155309&form=6&db=m SIRT2 promotes murine melanoma progression through natural killer cell inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34163012&form=6&db=m SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34235106&form=6&db=m Inhibition of SIRT1 Limits Self-Renewal and Oncogenesis by Inducing Senescence of Liver Cancer Stem Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34259031&form=6&db=m Modulation of Sirt1 and FoxO1 on Hypothalamic Leptin-Mediated Sympathetic Activation and Inflammation in Diet-Induced Obese Rats. causal interaction,unassigned 4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34407842&form=6&db=m SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34411362&form=6&db=m Jaridon 6, a new diterpene from Rabdosia rubescens (Hemsl.) Hara, can display anti-gastric cancer resistance by inhibiting SIRT1 and inducing autophagy. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34429771&form=6&db=m Emerging role of SIRT2 in non-small cell lung cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34437278&form=6&db=m B-cell Lymphomas Exhibit a Non-Oncogene Addiction to SIRT3. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34494279&form=6&db=m Improving SIRT1 by trehalose supplementation reduces oxidative stress, inflammation, and histopathological scores in the kidney of aged rats. diagnostic usage,ongoing research,unassigned 4,2,0 2.3.1.286 Nephrolithiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30674870&form=6&db=m Sirt3 suppresses calcium oxalate-induced renal tubular epithelial cell injury via modification of FoxO3a-mediated autophagy. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20622856&form=6&db=m A novel pathway regulates memory and plasticity via SIRT1 and miR-134. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25536118&form=6&db=m SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33128944&form=6&db=m Regulation of SIRT3 on mitochondrial functions and oxidative stress in Parkinson's disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34108853&form=6&db=m Sirtuin 2 (SIRT2): Confusing Roles in the Pathophysiology of Neurological Disorders. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24959710&form=6&db=m Spinal SIRT1 activation attenuates neuropathic pain in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27749604&form=6&db=m SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29222643&form=6&db=m Overexpression of SIRT2 Alleviates Neuropathic Pain and Neuroinflammation Through Deacetylation of Transcription Factor Nuclear Factor-Kappa B. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30342528&form=6&db=m Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31807151&form=6&db=m MicroRNA-448 modulates the progression of neuropathic pain by targeting sirtuin 1. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31938369&form=6&db=m Involvement of spinal SIRT1 in development of chronic constriction injury induced neuropathic pain in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,2 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32922581&form=6&db=m SIRT1 Mediates Neuropathic Pain Induced by Sciatic Nerve Chronic Constrictive Injury in the VTA-NAc Pathway. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34225609&form=6&db=m Role of SIRT1 in Neuropathic Pain from the Viewpoint of Neuroimmunity. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Neurilemmoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23175188&form=6&db=m The histone deacetylase SIRT2 stabilizes Myc oncoproteins. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23762270&form=6&db=m Pharmacological activation of Sirt1 ameliorates polyglutamine-induced toxicity through the regulation of autophagy. ongoing research,unassigned 4,0 2.3.1.286 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32158616&form=6&db=m SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3? activity in neuroblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17397914&form=6&db=m SIRT1 and neuronal diseases. causal interaction,unassigned 4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17633479&form=6&db=m [Research progression of deacetylase (SIRT1)] causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17637936&form=6&db=m Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17937892&form=6&db=m [SIRT1/PGC-1: a neuroprotective axis?] causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18282481&form=6&db=m The Sirtuin family: therapeutic targets to treat diseases of aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18336301&form=6&db=m Inhibitors of NAD+ dependent histone deacetylases (sirtuins). causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18774777&form=6&db=m SIRTUIN 1: regulating the regulator. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18799131&form=6&db=m The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19260974&form=6&db=m Silent information regulator, Sirtuin 1, and age-related diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19643082&form=6&db=m Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19826562&form=6&db=m Potential role of sirtuin as a therapeutic target for neurodegenerative diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19931429&form=6&db=m Sirtuins inhibitors: The approach to affinity and selectivity. therapeutic application,unassigned 4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20178071&form=6&db=m SIRT1 Inhibitory Diterpenoids from the Vietnamese Medicinal Plant Croton tonkinensis. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20601277&form=6&db=m Sirtuin activators: Designing molecules to extend life span. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21306906&form=6&db=m After the grape rush: Sirtuins as epigenetic drug targets in neurodegenerative disorders. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21907197&form=6&db=m Neuroprotective and metabolic effects of resveratrol: therapeutic implications for Huntington's disease and other neurodegenerative disorders. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22179316&form=6&db=m Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. therapeutic application,unassigned 4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22203920&form=6&db=m Translating cell survival and cell longevity into treatment strategies with SIRT1. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22233091&form=6&db=m SIRT1: new avenues of discovery for disorders of oxidative stress. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22563317&form=6&db=m SIRT2 as a Therapeutic Target for Age-Related Disorders. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22575359&form=6&db=m Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22642300&form=6&db=m Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22648412&form=6&db=m trans-(-)-?-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22730114&form=6&db=m Sirtuin activators and inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22885181&form=6&db=m Genetic analysis of the SIRT1 gene promoter in ventricular septal defects. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23570514&form=6&db=m Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23689277&form=6&db=m Sirtuin deacetylases in neurodegenerative diseases of aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24323420&form=6&db=m SIRT1 regulation modulates stroke outcome. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24496572&form=6&db=m Role of Sirt1 During the Ageing Process: Relevance to Protection of Synapses in the Brain. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24507186&form=6&db=m SIRT1 in neurodevelopment and brain senescence. causal interaction,unassigned 4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25195579&form=6&db=m Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics. therapeutic application,unassigned 4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25502412&form=6&db=m Molecular modelling studies of sirtuin 2 inhibitors using three-dimensional structure-activity relationship analysis and molecular dynamics simulations. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25515955&form=6&db=m Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton. ongoing research,therapeutic application,unassigned 1,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26862948&form=6&db=m Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27164052&form=6&db=m The role of mitochondrial sirtuins in health and disease. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27333745&form=6&db=m [SIRT1]. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27590140&form=6&db=m Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington's Disease Models. causal interaction,unassigned 4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27686535&form=6&db=m Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28086917&form=6&db=m Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28299833&form=6&db=m Unsupervised pharmacophore modeling combined with QSAR analyses revealed novel low micromolar SIRT2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28449871&form=6&db=m SIRT3 and mitochondrial metabolism in neurodegenerative diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28578695&form=6&db=m SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease. causal interaction,diagnostic usage,unassigned 4,1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29324783&form=6&db=m SIRT3 activator Honokiol attenuates ?-Amyloid by modulating amyloidogenic pathway. causal interaction,unassigned 4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29494741&form=6&db=m SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30448921&form=6&db=m Probing the mechanism of SIRT1 activation by a 1,4-dihydropyridine. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31505260&form=6&db=m SIRT2: Controversy and multiple roles in disease and physiology. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31711765&form=6&db=m Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32086007&form=6&db=m The systemic role of SIRT1 in exercise mediated adaptation. causal interaction,unassigned 4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32148659&form=6&db=m Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32310828&form=6&db=m SIRT1 regulates O-GlcNAcylation of tau through OGT. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32320732&form=6&db=m SIRT1 Regulation in Ageing and Obesity. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32549218&form=6&db=m Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33175932&form=6&db=m Grape seed procyanidins suppress the apoptosis and senescence of chondrocytes and ameliorates osteoarthritis via the DPP4-Sirt1 pathway. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33597872&form=6&db=m SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33877561&form=6&db=m Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34273848&form=6&db=m Attenuation of Pb-induced A? generation and autophagic dysfunction via activation of SIRT1: Neuroprotective properties of resveratrol. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neurofibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22523472&form=6&db=m Resveratrol Targeting of Carcinogen-Induced Brain Endothelial Cell Inflammation Biomarkers MMP-9 and COX-2 is Sirt1-Independent. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27350577&form=6&db=m SIRT2 Plays Significant Roles in Lipopolysaccharides-Induced Neuroinflammation and Brain Injury in Mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27735947&form=6&db=m Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28193684&form=6&db=m An Agonist of the Protective Factor SIRT1 Improves Functional Recovery and Promotes Neuronal Survival by Attenuating Inflammation after Spinal Cord Injury. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29222643&form=6&db=m Overexpression of SIRT2 Alleviates Neuropathic Pain and Neuroinflammation Through Deacetylation of Transcription Factor Nuclear Factor-Kappa B. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30007474&form=6&db=m Sirtuin 1 and Alzheimer's disease: An up-to-date review. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30510203&form=6&db=m SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain. causal interaction,unassigned 4,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31471557&form=6&db=m Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31807151&form=6&db=m MicroRNA-448 modulates the progression of neuropathic pain by targeting sirtuin 1. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32203080&form=6&db=m Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32298740&form=6&db=m Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32336744&form=6&db=m Schisandrin ameliorates cognitive deficits, endoplasmic reticulum stress and neuroinflammation in streptozotocin (STZ)-induced Alzheimer's disease rats. causal interaction,unassigned 4,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32485218&form=6&db=m Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse model. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32823525&form=6&db=m Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014276&form=6&db=m The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33269110&form=6&db=m The Critical Role of SIRT1 in Parkinson's Disease: Mechanism and Therapeutic Considerations. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34393764&form=6&db=m Effects of Lipotoxicity in Brain Microvascular Endothelial Cells During Sirt3 Deficiency-Potential Role in Comorbid Alzheimer's Disease. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34493950&form=6&db=m Dexmedetomidine Ameliorates Hippocampus Injury and Cognitive Dysfunction Induced by Hepatic Ischemia/Reperfusion by Activating SIRT3-Mediated Mitophagy and Inhibiting Activation of the NLRP3 Inflammasome in Young Rats. therapeutic application,unassigned 4,0 2.3.1.286 Nevus, Pigmented http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26743598&form=6&db=m Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 nicotinamide phosphoribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28159473&form=6&db=m Nicotinamide phosphoribosyltransferase (Nampt) may serve as the marker for osteoblast differentiation of bone marrow-derived mesenchymal stem cells. causal interaction,unassigned 4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20651844&form=6&db=m Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21525818&form=6&db=m SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22902550&form=6&db=m miR-34a/SIRT1/p53 is Suppressed by Ursodeoxycholic Acid in Rat Liver and Activated by Disease Severity in Human Non-alcoholic Fatty Liver Disease. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25267960&form=6&db=m A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25358448&form=6&db=m Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients. diagnostic usage,ongoing research,unassigned 4,3,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26064858&form=6&db=m SIRT3 as a Regulator of Non-alcoholic Fatty Liver Disease. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26435214&form=6&db=m Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26912655&form=6&db=m SIRT3 regulates ?-SMA production through the succinate dehydrogenase-GPR91 pathway in hepatic stellate cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27756894&form=6&db=m Altered microRNA-9 Expression Level is Directly Correlated with Pathogenesis of Nonalcoholic Fatty Liver Disease by Targeting Onecut2 and SIRT1. causal interaction,unassigned 4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28533219&form=6&db=m Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29310441&form=6&db=m Dihydromyricetin Ameliorates Nonalcoholic Fatty Liver Disease by Improving Mitochondrial Respiratory Capacity and Redox Homeostasis Through Modulation of SIRT3 Signaling. causal interaction,unassigned 4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30056271&form=6&db=m Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30221089&form=6&db=m Effects of resveratrol, exercises and their combination on Farnesoid X receptor, Liver X receptor and Sirtuin 1 gene expression and apoptosis in the liver of elderly rats with nonalcoholic fatty liver. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30785444&form=6&db=m Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31683679&form=6&db=m Lipidomic Analysis of the Protective Effects of Shenling Baizhu San on Non-Alcoholic Fatty Liver Disease in Rats. ongoing research,unassigned 4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33098868&form=6&db=m miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload. ongoing research,unassigned 4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33754067&form=6&db=m NAD+-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.286 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33902605&form=6&db=m Elucidation of SIRT-1/PGC-1?-associated mitochondrial dysfunction and autophagy in nonalcoholic fatty liver disease. ongoing research,unassigned 4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17090532&form=6&db=m SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18599274&form=6&db=m The role of sirtuin proteins in obesity. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18820948&form=6&db=m Association of SIRT1 gene variation with visceral obesity. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18837744&form=6&db=m Sirtuin gene expression in human mononuclear cells is modulated by caloric restriction. therapeutic application,unassigned 4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19430421&form=6&db=m SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20335544&form=6&db=m Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20601277&form=6&db=m Sirtuin activators: Designing molecules to extend life span. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21048357&form=6&db=m Roles of FoxO1 and Sirt1 in the central regulation of food intake. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21540183&form=6&db=m Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21760635&form=6&db=m Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21871827&form=6&db=m SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22553202&form=6&db=m Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22730114&form=6&db=m Sirtuin activators and inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22885181&form=6&db=m Genetic analysis of the SIRT1 gene promoter in ventricular septal defects. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22967499&form=6&db=m Leucine Supplementation Increases SIRT1 Expression and Prevents Mitochondrial Dysfunction and Metabolic Disorders in High Fat Diet-induced Obese Mice. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23259556&form=6&db=m SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23805409&form=6&db=m Sirtuin-1 is a nutrient-dependent modulator of inflammation. causal interaction,unassigned 4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23834033&form=6&db=m Elevated microRNA-34a in obesity reduces NAD(+) levels and SIRT1 activity by directly targeting NAMPT. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23876548&form=6&db=m Association between low SIRT1 expression in visceral and subcutaneous adipose tissues and metabolic abnormalities in women with obesity and type 2 diabetes. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23933590&form=6&db=m Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: A pilot study. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23956348&form=6&db=m Skeletal Muscle MnSOD, Mitochondrial Complex II, and SIRT3 Enzyme Activities Are Decreased in Maternal Obesity During Human Pregnancy and Gestational Diabetes Mellitus. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24020000&form=6&db=m The Roles of SIRT1 in Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24113524&form=6&db=m Sirtuin 1 is upregulated in young obese Zucker rat cerebral arteries. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24947673&form=6&db=m Minireview: Central Sirt1 Regulates Energy Balance via the Melanocortin System and Alternate Pathways. causal interaction,unassigned 4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25782072&form=6&db=m High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27000941&form=6&db=m SIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts Endothelial-Dependent Vasorelaxation in Mice and Human with Obesity. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27317762&form=6&db=m Sirt1 decreased adipose inflammation by interacting with Akt2 and inhibiting mTOR/S6K1 pathway in mice. causal interaction,unassigned 4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27378396&form=6&db=m Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27432859&form=6&db=m Vascular Smooth Muscle Sirtuin-1 Protects Against Diet-Induced Aortic Stiffness. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28335087&form=6&db=m Ursolic acid and mechanisms of actions on adipose and muscle tissue: a systematic review. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28375738&form=6&db=m Sirt3 Deficiency Increased the Vulnerability of Pancreatic Beta Cells to Oxidative Stress-Induced Dysfunction. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28533219&form=6&db=m Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29050301&form=6&db=m MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1). causal interaction,unassigned 4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29236311&form=6&db=m miR-221 negatively regulates inflammation and insulin sensitivity in white adipose tissue by repression of sirtuin-1 (SIRT1). causal interaction,unassigned 4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30374331&form=6&db=m High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30510203&form=6&db=m SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain. causal interaction,unassigned 4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30620711&form=6&db=m The effect of adipocyte-macrophage cross-talk in obesity-related breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30671172&form=6&db=m Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30877853&form=6&db=m Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators. causal interaction,unassigned 4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30890694&form=6&db=m Pharmacologic or genetic activation of SIRT1 attenuates the fat-induced decrease in beta-cell function in vivo. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31296102&form=6&db=m Adipose-specific knockdown of Sirt1 results in obesity and insulin resistance by promoting exosomes release. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31321353&form=6&db=m Anti-obesity Activity of Ethanol Extract from Bitter Melon in Mice Fed High-Fat Diet. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31425381&form=6&db=m SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION. causal interaction,unassigned 4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31462690&form=6&db=m Reduced SIRT1 and SIRT2 expression promotes adipogenesis of human visceral adipose stem cells and associates with accumulation of visceral fat in human obesity. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31464387&form=6&db=m Mitochondrial Hyperacetylation in the Failing Hearts of Obese Patients Mediated Partly by a Reduction in SIRT3: The Involvement of the Mitochondrial Permeability Transition Pore. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31711765&form=6&db=m Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31712319&form=6&db=m Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue. ongoing research,unassigned 4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32218740&form=6&db=m Sirtuin1 Role in the Melatonin Protective Effects Against Obesity-Related Heart Injury. causal interaction,unassigned 4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32320732&form=6&db=m SIRT1 Regulation in Ageing and Obesity. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32486051&form=6&db=m SIRT1 Activation by Equisetum Arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33087457&form=6&db=m Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity. causal interaction,unassigned 4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33159388&form=6&db=m MiR-22 modulates the expression of lipogenesis-related genes and promotes hepatic steatosis in vitro. ongoing research,unassigned 4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33371997&form=6&db=m Ketogenesis and SIRT1 as a tool in managing obesity. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33612619&form=6&db=m SIRT1 as a Potential Biomarker for Obesity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33930006&form=6&db=m Genomics of aging: The role of sirtuin and metabolic health. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34259031&form=6&db=m Modulation of Sirt1 and FoxO1 on Hypothalamic Leptin-Mediated Sympathetic Activation and Inflammation in Diet-Induced Obese Rats. causal interaction,unassigned 4,0 2.3.1.286 Obesity, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18820948&form=6&db=m Association of SIRT1 gene variation with visceral obesity. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Obesity, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23933590&form=6&db=m Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: A pilot study. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Obesity, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33612619&form=6&db=m SIRT1 as a Potential Biomarker for Obesity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Obesity, Maternal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23956348&form=6&db=m Skeletal Muscle MnSOD, Mitochondrial Complex II, and SIRT3 Enzyme Activities Are Decreased in Maternal Obesity During Human Pregnancy and Gestational Diabetes Mellitus. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.286 Obesity, Maternal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30641941&form=6&db=m SIRT1 Attenuates Kidney Disorders in Male Offspring Due to Maternal High-Fat Diet. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Obesity, Morbid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21760635&form=6&db=m Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Ophthalmoplegia, Chronic Progressive External http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20649551&form=6&db=m Mitochondrial respiratory dysfunction-elicited oxidative stress and posttranslational protein modification in mitochondrial diseases. causal interaction,unassigned 4,0 2.3.1.286 Optic Atrophy, Autosomal Dominant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27890624&form=6&db=m Mitochondrial cAMP prevents apoptosis modulating Sirt3 protein level and OPA1 processing in cardiac myoblast cells. causal interaction,unassigned 4,0 2.3.1.286 Optic Atrophy, Autosomal Dominant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31037127&form=6&db=m SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Optic Atrophy, Autosomal Dominant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31269804&form=6&db=m Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Optic Nerve Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29494741&form=6&db=m SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Optic Neuritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23892278&form=6&db=m The role of SIRT1 in ocular aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Optic Neuritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29494741&form=6&db=m SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19714620&form=6&db=m SIRT1 regulation of apoptosis of human chondrocytes. ongoing research,unassigned 4,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21742641&form=6&db=m SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22044919&form=6&db=m Resveratrol inhibits interleukin 1?-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-?B activity. therapeutic application,unassigned 4,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22507555&form=6&db=m Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway. ongoing research,unassigned 4,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23723318&form=6&db=m Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27752896&form=6&db=m Effects of SIRT1 gene knock-out via activation of SREBP2 protein-mediated PI3K/AKT signaling on osteoarthritis in mice. ongoing research,unassigned 4,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29922443&form=6&db=m Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30600470&form=6&db=m Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2 2.3.1.286 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33175932&form=6&db=m Grape seed procyanidins suppress the apoptosis and senescence of chondrocytes and ameliorates osteoarthritis via the DPP4-Sirt1 pathway. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27863529&form=6&db=m The expression of SIRT1 in articular cartilage of patients with knee osteoarthritis and its correlation with disease severity. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19260974&form=6&db=m Silent information regulator, Sirtuin 1, and age-related diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25228047&form=6&db=m Sirtuin 1 activity in peripheral blood mononuclear cells of patients with osteoporosis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28542607&form=6&db=m SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2. therapeutic application,unassigned 4,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31486477&form=6&db=m MicroRNA-579-3p promotes the progression of osteoporosis by inhibiting osteogenic differentiation of mesenchymal stem cells through regulating Sirt1. diagnostic usage,ongoing research,unassigned 4,2,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31880520&form=6&db=m SIRT2 deficiency prevents age-related bone loss in rats by inhibiting osteoclastogenesis. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32289519&form=6&db=m Sirtuin 1 deficiency decreases bone mass and increases bone marrow adiposity in a mouse model of chronic energy deficiency. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33393735&form=6&db=m Role of sirtuins in bone biology: Potential implications for novel therapeutic strategies for osteoporosis. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.286 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33878033&form=6&db=m Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26936024&form=6&db=m Expression of Leptin and Sirtuin-1 is associated with poor prognosis in patients with osteosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27793039&form=6&db=m SIRT1 promotes metastasis of human osteosarcoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30304565&form=6&db=m SIRT1-ZEB1-positive feedback promotes epithelial-mesenchymal transition process and metastasis of osteosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.3.1.286 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30692914&form=6&db=m Sirtuin 1 and Autophagy Attenuate Cisplatin-Induced Hair Cell Death in the Mouse Cochlea and Zebrafish Lateral Line. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18850005&form=6&db=m Deacetylation of cortactin by SIRT1 promotes cell migration. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20160719&form=6&db=m Identification of DBC1 as a transcriptional repressor for BRCA1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23843607&form=6&db=m PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25323003&form=6&db=m A novel crosstalk between BRCA1 and sirtuin 1 in ovarian cancer. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27186285&form=6&db=m Effect of the BRCA1-SIRT1-EGFR axis on cisplatin sensitivity in ovarian cancer. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27216459&form=6&db=m Down-regulation of SIRT3 promotes ovarian carcinoma metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,3 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28878214&form=6&db=m Hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating SIRT1 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29422491&form=6&db=m Targeting estrogen receptor beta (ER?) for treatment of ovarian cancer: importance of KDM6B and SIRT1 for ER? expression and functionality. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29904404&form=6&db=m MicroRNA-142-3p inhibits cell proliferation and chemoresistance in ovarian cancer via targeting sirtuin 1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30058682&form=6&db=m Functional role of SIRT1-induced HMGB1 expression and acetylation in migration, invasion and angiogenesis of ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31113446&form=6&db=m Development and validation of SIRT3-related nomogram predictive of overall survival in patients with serous ovarian cancer. diagnostic usage,ongoing research,unassigned 4,2,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31247208&form=6&db=m ABT737 enhances ovarian cancer cells sensitivity to cisplatin through regulation of mitochondrial fission via Sirt3 activation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32388637&form=6&db=m Sirtuin1 expression and survival in endometrial and clear-cell uterine cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32398958&form=6&db=m A new SIRT1 inhibitor, MHY2245, induces autophagy and inhibits energy metabolism via PKM2/mTOR pathway in human ovarian cancer cells. therapeutic application,unassigned 4,0 2.3.1.286 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32934730&form=6&db=m Potential relationship between Sirt3 and autophagy in ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.3.1.286 Overnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23805409&form=6&db=m Sirtuin-1 is a nutrient-dependent modulator of inflammation. causal interaction,unassigned 4,0 2.3.1.286 Overnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25067957&form=6&db=m Targeting sirtuins for the treatment of diabetes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21677689&form=6&db=m SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22640743&form=6&db=m SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of ?-catenin. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23175188&form=6&db=m The histone deacetylase SIRT2 stabilizes Myc oncoproteins. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24484175&form=6&db=m Sirtuin 1 facilitates chemoresistance of pancreatic cancer cells by regulating adaptive response to chemotherapy-induced stress. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24909164&form=6&db=m SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25843411&form=6&db=m SIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26121130&form=6&db=m SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26282546&form=6&db=m Emerging Drug Target In Pancreatic Cancer: Placing Sirtuin 1 on the Canvas. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28351313&form=6&db=m SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29685974&form=6&db=m Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30868406&form=6&db=m SIRT1 promotes GLUT1 expression and bladder cancer progression via regulation of glucose uptake. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34163012&form=6&db=m SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30401412&form=6&db=m Niacin Pretreatment Attenuates Ischemia and Reperfusion of Pancreas-induced Acute Pancreatitis and Remote Lung Injury Through Suppressing Oxidative Stress and Inflammation and Activation of SIRT1. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30405152&form=6&db=m Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Pancytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31178326&form=6&db=m The Sirt1 activator resveratrol improved hematopoiesis in pancytopenia mice induced by irradiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,2 2.3.1.286 Parasitemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31905606&form=6&db=m Origin of Monocytes/Macrophages Contributing to Chronic Inflammation in Chagas Disease: SIRT1 Inhibition of FAK-NF?B-Dependent Proliferation and Proinflammatory Activation of Macrophages. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Parasitic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22730114&form=6&db=m Sirtuin activators and inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17588900&form=6&db=m Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. therapeutic application,unassigned 4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18282481&form=6&db=m The Sirtuin family: therapeutic targets to treat diseases of aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20815175&form=6&db=m [Sirtuins--modulation of their activity as a novel therapeutic target]. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21306906&form=6&db=m After the grape rush: Sirtuins as epigenetic drug targets in neurodegenerative disorders. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21479103&form=6&db=m Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22121876&form=6&db=m Small-molecule chromatin-modifying agents: therapeutic applications. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22233091&form=6&db=m SIRT1: new avenues of discovery for disorders of oxidative stress. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22642300&form=6&db=m Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23689277&form=6&db=m Sirtuin deacetylases in neurodegenerative diseases of aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25389371&form=6&db=m Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65. causal interaction,unassigned 4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25502412&form=6&db=m Molecular modelling studies of sirtuin 2 inhibitors using three-dimensional structure-activity relationship analysis and molecular dynamics simulations. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25536118&form=6&db=m SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25558243&form=6&db=m Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake. causal interaction,unassigned 4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26819971&form=6&db=m Sirt1 in cerebral ischemia. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27333745&form=6&db=m [SIRT1]. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28449871&form=6&db=m SIRT3 and mitochondrial metabolism in neurodegenerative diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28478325&form=6&db=m Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3?/?-catenin pathway. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28578695&form=6&db=m SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease. causal interaction,diagnostic usage,unassigned 4,1,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30562735&form=6&db=m miR-486-3p Influences the Neurotoxicity of a-Synuclein by Targeting the SIRT2 Gene and the Polymorphisms at Target Sites Contributing to Parkinson's Disease. causal interaction,unassigned 4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31214610&form=6&db=m Rs2015 Polymorphism in miRNA Target Site of Sirtuin2 Gene Is Associated with the Risk of Parkinson's Disease in Chinese Han Population. causal interaction,unassigned 4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33128944&form=6&db=m Regulation of SIRT3 on mitochondrial functions and oxidative stress in Parkinson's disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33269110&form=6&db=m The Critical Role of SIRT1 in Parkinson's Disease: Mechanism and Therapeutic Considerations. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33597872&form=6&db=m SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33877561&form=6&db=m Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34251648&form=6&db=m SIRT1 Protects Dopaminergic Neurons in Parkinson's Disease Models via PGC-1?-Mediated Mitochondrial Biogenesis. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34151764&form=6&db=m Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Periapical Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29363137&form=6&db=m A potential role for the silent information regulator 2 homologue 1 (SIRT1) in periapical periodontitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.3.1.286 Periapical Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30101822&form=6&db=m Expression of silent information regulator 2 homolog 1 (SIRT1) in periapical granulomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 2.3.1.286 Periapical Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29363137&form=6&db=m A potential role for the silent information regulator 2 homologue 1 (SIRT1) in periapical periodontitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.3.1.286 Periapical Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30101822&form=6&db=m Expression of silent information regulator 2 homolog 1 (SIRT1) in periapical granulomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 2.3.1.286 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30498174&form=6&db=m Assessment of Sirtuin 3 and Sirtuin 4 Level in Patients with Diabetes Mellitus and Periodontitis: A Clinical Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.3.1.286 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32323205&form=6&db=m SIRT2 Inhibition Improves Functional Motor Recovery After Peripheral Nerve Injury. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28894448&form=6&db=m Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Persistent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26135889&form=6&db=m Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31639451&form=6&db=m LONP1 induction by SRT1720 attenuates mitochondrial dysfunction against high glucose induced neurotoxicity in PC12 cells. ongoing research,unassigned 4,0 2.3.1.286 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28521414&form=6&db=m Association of FGFR2 rs2981582, SIRT1 rs12778366, STAT3 rs744166 gene polymorphisms with pituitary adenoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.3.1.286 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31747893&form=6&db=m SIRT1 (rs3740051) role in pituitary adenoma development. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.286 Pleural Effusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31341634&form=6&db=m A novel Ubc9 -dependent pathway regulates SIRT1- ER-? Axis and BRCA1-associated TNBC lung metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22262770&form=6&db=m Sirt1 protects against thrombomodulin down-regulation and lung coagulation after particulate matter exposure. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24633890&form=6&db=m SIRT1 protects against cigarette smoke-induced lung oxidative stress via FOXO3-dependent mechanism. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25659903&form=6&db=m Sirt1 restrains lung inflammasome activation in a murine model of sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28193684&form=6&db=m An Agonist of the Protective Factor SIRT1 Improves Functional Recovery and Promotes Neuronal Survival by Attenuating Inflammation after Spinal Cord Injury. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28894448&form=6&db=m Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30014231&form=6&db=m Resolvin D1 Promotes SIRT1 Expression to Counteract the Activation of STAT3 and NF-?B in Mice with Septic-Associated Lung Injury. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30401407&form=6&db=m Niacin Pretreatment Attenuates Lung Ischemia and Reperfusion-Induced Pulmonary Barrier Function Impairment by Reducing Oxidative Stress and Activating SIRT1 in an Isolated-Perfused Rat Lung Model. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25526506&form=6&db=m Serum sirtuin 1 levels in patients with polycystic ovary syndrome. diagnostic usage,ongoing research,unassigned 4,4,0 2.3.1.286 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33301839&form=6&db=m Energy sensors and reproductive hypothalamo-pituitary ovarian axis (HPO) in female mammals: Role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1). causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28122311&form=6&db=m SIRT1 inhibits releases of HMGB1 and HSP70 from human umbilical vein endothelial cells caused by IL-6 and the serum from a preeclampsia patient and protects the cells from death. ongoing research,unassigned 4,0 2.3.1.286 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32411327&form=6&db=m Analysis of SIRT1 Expression in Plasma and in an In Vitro Model of Preeclampsia. diagnostic usage,ongoing research,unassigned 4,4,0 2.3.1.286 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34407842&form=6&db=m SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.286 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34407842&form=6&db=m SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.286 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28811647&form=6&db=m Biogenesis of Pro-senescent Microparticles by Endothelial Colony Forming Cells from Premature Neonates is driven by SIRT1-Dependent Epigenetic Regulation of MKK6. causal interaction,unassigned 4,0 2.3.1.286 Primary Ovarian Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33301839&form=6&db=m Energy sensors and reproductive hypothalamo-pituitary ovarian axis (HPO) in female mammals: Role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1). causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Prion Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18799131&form=6&db=m The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Prion Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22575359&form=6&db=m Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22944623&form=6&db=m Cortactin is associated with tumour progression and poor prognosis in prostate cancer and SIRT2 other than HADC6 may work as facilitator in situ. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25529796&form=6&db=m Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16923962&form=6&db=m Hormonal control of androgen receptor function through SIRT1. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17638871&form=6&db=m SIRT1 is significantly elevated in mouse and human prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18637271&form=6&db=m Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19377286&form=6&db=m Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20687223&form=6&db=m MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20956937&form=6&db=m NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22050448&form=6&db=m Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells. causal interaction,unassigned 4,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22081864&form=6&db=m Editorial comment to inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells. causal interaction,unassigned 4,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22944623&form=6&db=m Cortactin is associated with tumour progression and poor prognosis in prostate cancer and SIRT2 other than HADC6 may work as facilitator in situ. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23038275&form=6&db=m SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23248098&form=6&db=m Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25529796&form=6&db=m Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26317998&form=6&db=m SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26439987&form=6&db=m MicroRNA-212 negatively regulates starvation induced autophagy in prostate cancer cells by inhibiting SIRT1 and is a modulator of angiogenesis and cellular senescence. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26636371&form=6&db=m Energy-Based Pharmacophore and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling Combined with Virtual Screening To Identify Novel Small-Molecule Inhibitors of Silent Mating-Type Information Regulation 2 Homologue 1 (SIRT1). causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26988912&form=6&db=m Loss of miR-449a in ERG-associated prostate cancer promotes the invasive phenotype by inducing SIRT1. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27764779&form=6&db=m Mesenchymal stem cells overexpressing Sirt1 inhibit prostate cancer growth by recruiting natural killer cells and macrophages. ongoing research,unassigned 4,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29262808&form=6&db=m Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29416748&form=6&db=m SIRT1 contributes to neuroendocrine differentiation of prostate cancer. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29574020&form=6&db=m SIRT1 and microRNAs: The role in breast, lung and prostate cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31092575&form=6&db=m SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to Vesicular Stomatitis Virus Oncolysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31315374&form=6&db=m [Effect of long-chain non-coding RNA-AC024560.2 on proliferation and invasion of prostate cancer cells by targeted regulation of miR-30a-5p]. causal interaction,unassigned 4,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33115805&form=6&db=m Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33282964&form=6&db=m The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33617947&form=6&db=m Androgen deprivation-induced elevated nuclear SIRT1 promotes prostate tumor cell survival by reactivation of AR signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17201918&form=6&db=m SirT1 modulates the estrogen-insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18270565&form=6&db=m Sirt1 deficiency attenuates spermatogenesis and germ cell function. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19173036&form=6&db=m SIRT1, is it a tumor promoter or tumor suppressor? causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20169165&form=6&db=m SIRT1 negatively regulates the mammalian target of rapamycin. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20622856&form=6&db=m A novel pathway regulates memory and plasticity via SIRT1 and miR-134. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21130087&form=6&db=m SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cells. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21965330&form=6&db=m Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22014574&form=6&db=m SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22986367&form=6&db=m Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23255128&form=6&db=m Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23457303&form=6&db=m Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23799088&form=6&db=m Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23898190&form=6&db=m SIRT2 directs the replication stress response through CDK9 deacetylation. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24039251&form=6&db=m SIRT1 redresses tissue inhibitor of matrix metalloproteinase-1/matrix metalloproteinase-9 imbalance in the development of mouse emphysema and human COPD. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24351289&form=6&db=m SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF-1?-dependent glycolysis. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24356887&form=6&db=m Sirt1 activation ameliorates renal fibrosis by inhibiting the TGF-?/Smad3 pathway. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24370889&form=6&db=m Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24518759&form=6&db=m Accelerated senescence of cord blood endothelial progenitor cells in premature neonates is driven by SIRT1 decreased expression. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24567379&form=6&db=m Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24909164&form=6&db=m SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25013930&form=6&db=m Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25072851&form=6&db=m SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25155613&form=6&db=m SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25284742&form=6&db=m Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25349202&form=6&db=m SIRT2 Regulates LPS-Induced Renal Tubular CXCL2 and CCL2 Expression. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25424328&form=6&db=m Sirtuin1 Maintains Actin Cytoskeleton by Deacetylation of Cortactin in Injured Podocytes. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25500546&form=6&db=m High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25501752&form=6&db=m Resveratrol possesses protective effects in a pristane-induced lupus mouse model. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25516717&form=6&db=m SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25589773&form=6&db=m SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1?. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25659903&form=6&db=m Sirt1 restrains lung inflammasome activation in a murine model of sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25962702&form=6&db=m SIRT3 deficiency impairs mitochondrial and contractile function in the heart. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26524632&form=6&db=m Preserved recovery of cardiac function following ischemia-reperfusion in mice lacking SIRT3. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26698917&form=6&db=m Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27000941&form=6&db=m SIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts Endothelial-Dependent Vasorelaxation in Mice and Human with Obesity. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27255815&form=6&db=m Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27350577&form=6&db=m SIRT2 Plays Significant Roles in Lipopolysaccharides-Induced Neuroinflammation and Brain Injury in Mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27744418&form=6&db=m The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27764247&form=6&db=m SIRT1-PGC1?-NF?B Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27794418&form=6&db=m Sirt3 deficiency exacerbates diabetic cardiac dysfunction: Role of Foxo3A-Parkin-mediated mitophagy. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28258190&form=6&db=m SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28375738&form=6&db=m Sirt3 Deficiency Increased the Vulnerability of Pancreatic Beta Cells to Oxidative Stress-Induced Dysfunction. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28461331&form=6&db=m Sirtuin 2 mutations in human cancers impair its function in genome maintenance. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28559847&form=6&db=m High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28811647&form=6&db=m Biogenesis of Pro-senescent Microparticles by Endothelial Colony Forming Cells from Premature Neonates is driven by SIRT1-Dependent Epigenetic Regulation of MKK6. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28894448&form=6&db=m Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29050301&form=6&db=m MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1). causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29074993&form=6&db=m Epidermal SIRT1 regulates inflammation, cell migration, and wound healing. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29236713&form=6&db=m Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29409011&form=6&db=m Cardiomyocyte Specific Deletion of Sirt1 Gene Sensitizes Myocardium to Ischemia and Reperfusion Injury. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29532856&form=6&db=m SIRT3 deficiency exacerbates p53/Parkin?mediated mitophagy inhibition and promotes mitochondrial dysfunction: Implication for aged hearts. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29765980&form=6&db=m Aerobic Interval Training Regulated SIRT3 Attenuates High-Fat-Diet-Associated Cognitive Dysfunction. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29777578&form=6&db=m Sirt3 deficiency impairs neurovascular recovery in ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30021675&form=6&db=m Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30025390&form=6&db=m SIRT1 Involved in the Regulation of Alternative Splicing Affects the DNA Damage Response in Neural Stem Cells. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30250024&form=6&db=m SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30298020&form=6&db=m Fibrogenic Secretome of Sirtuin 1-Deficient Endothelial Cells: Wnt, Notch and Glycocalyx Rheostat. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30368983&form=6&db=m Sirtuin3 deficiency exacerbates carbon tetrachloride-induced hepatic injury in mice. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30380732&form=6&db=m Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30389773&form=6&db=m Mitochondrial Deacetylase SIRT3 Plays an Important Role in Donor T Cell Responses after Experimental Allogeneic Hematopoietic Transplantation. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30445987&form=6&db=m Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30533173&form=6&db=m Geniposide Protects against Obesity-Related Cardiac Injury through AMPK?- and Sirt1-Dependent Mechanisms. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30622543&form=6&db=m A Possible Reason to Induce Acute Graft-vs.-Host Disease After Hematopoietic Stem Cell Transplantation: Lack of Sirtuin-1 in CD4+ T Cells. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30656603&form=6&db=m Sirtuin 3 inhibition induces mitochondrial stress in tongue cancer by targeting mitochondrial fission and the JNK-Fis1 biological axis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30774023&form=6&db=m SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30785444&form=6&db=m Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31037127&form=6&db=m SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31115479&form=6&db=m Sirt1 inhibits HG-induced endothelial injury: Role of Mff-based mitochondrial fission and F?actin homeostasis-mediated cellular migration. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31178326&form=6&db=m The Sirt1 activator resveratrol improved hematopoiesis in pancytopenia mice induced by irradiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,2 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31201798&form=6&db=m Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31269804&form=6&db=m Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31296102&form=6&db=m Adipose-specific knockdown of Sirt1 results in obesity and insulin resistance by promoting exosomes release. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31425381&form=6&db=m SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31658614&form=6&db=m Inducible Cardiac-Specific Deletion of Sirt1 in Male Mice Reveals Progressive Cardiac Dysfunction and Sensitization of the Heart to Pressure Overload. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31704100&form=6&db=m CO ameliorates endothelial senescence induced by 5-fluorouracil through SIRT1 activation. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31880520&form=6&db=m SIRT2 deficiency prevents age-related bone loss in rats by inhibiting osteoclastogenesis. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31954883&form=6&db=m SIRT2 Contributes to the Regulation of Intestinal Cell Proliferation and Differentiation. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32119761&form=6&db=m SIRT3 deficiency delays diabetic skin wound healing via oxidative stress and necroptosis enhancement. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32148659&form=6&db=m Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32289519&form=6&db=m Sirtuin 1 deficiency decreases bone mass and increases bone marrow adiposity in a mouse model of chronic energy deficiency. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32485218&form=6&db=m Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse model. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32630813&form=6&db=m SIRT1 Deficiency, Specifically in Fibroblasts, Decreases Apoptosis Resistance and Is Associated with Resolution of Lung-Fibrosis. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32835604&form=6&db=m Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32912335&form=6&db=m SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1?-LIPIN 1 pathway and increasing CD36 through Nrf2. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014281&form=6&db=m LCZ696 Ameliorates Oxidative Stress and Pressure Overload-Induced Pathological Cardiac Remodeling by Regulating the Sirt3/MnSOD Pathway. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33087457&form=6&db=m Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33233553&form=6&db=m SIRT3 Deficiency Sensitizes Angiotensin-II-Induced Renal Fibrosis. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33247214&form=6&db=m MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33423553&form=6&db=m SIRT3 deficiency increases mitochondrial oxidative stress and promotes migration of retinal pigment epithelial cells. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33519483&form=6&db=m Formononetin Activates the Nrf2/ARE Signaling Pathway Via Sirt1 to Improve Diabetic Renal Fibrosis. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33664876&form=6&db=m SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation. causal interaction,unassigned 4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34095262&form=6&db=m Sirt3 Protects Against Thoracic Aortic Dissection Formation by Reducing Reactive Oxygen Species, Vascular Inflammation, and Apoptosis of Smooth Muscle Cells. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34249270&form=6&db=m Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34393764&form=6&db=m Effects of Lipotoxicity in Brain Microvascular Endothelial Cells During Sirt3 Deficiency-Potential Role in Comorbid Alzheimer's Disease. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34407842&form=6&db=m SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34433910&form=6&db=m Sirt1 deficiency upregulates glutathione metabolism to prevent hepatocellular carcinoma initiation in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34514931&form=6&db=m A potential role of Sirtuin3 and its target enzyme activities in patients with ovarian endometrioma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30386303&form=6&db=m SIRT1 Is a Potential Drug Target for Treatment of Diabetic Kidney Disease. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33121427&form=6&db=m SIRT1: Mechanism and Protective in Diabetic Nephropathy. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26499368&form=6&db=m Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase, Sirt1. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28257794&form=6&db=m SIRT1, a Class III histone deacetylase, regulates LPS-induced inflammation in human keratinocytes and mediates the anti-inflammatory effects of hinokitiol. therapeutic application,unassigned 4,0 2.3.1.286 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31495284&form=6&db=m Salidroside inhibits MAPK, NF-?B, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33323018&form=6&db=m Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-?B and MAPKs signaling pathways. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25284742&form=6&db=m Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans. causal interaction,unassigned 4,0 2.3.1.286 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26273643&form=6&db=m Regulation of Cell Cycle Regulators by SIRT1 Contributes to Resveratrol-Mediated Prevention of Pulmonary Arterial Hypertension. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29369849&form=6&db=m Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation: role in pulmonary arterial hypertension. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.286 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32303670&form=6&db=m Effect of Aldosterone on Senescence and Proliferation Inhibition of Endothelial Progenitor Cells Induced by Sirtuin 1 (SIRT1) in Pulmonary Arterial Hypertension. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18174544&form=6&db=m SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19017741&form=6&db=m Future treatments for chronic obstructive pulmonary disease and its comorbidities. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19260974&form=6&db=m Silent information regulator, Sirtuin 1, and age-related diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19376817&form=6&db=m A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22796566&form=6&db=m Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23774840&form=6&db=m Potential Mechanisms Linking Atherosclerosis and Increased Cardiovascular Risk in COPD: Focus On Sirtuins. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24039251&form=6&db=m SIRT1 redresses tissue inhibitor of matrix metalloproteinase-1/matrix metalloproteinase-9 imbalance in the development of mouse emphysema and human COPD. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24289075&form=6&db=m Resveratrol attenuates left ventricular remodeling in old rats with COPD induced by cigarette smoke exposure and LPS instillation. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24624081&form=6&db=m Vestibular rehabilitation ameliorates chronic dizziness through the SIRT1 axis. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24633890&form=6&db=m SIRT1 protects against cigarette smoke-induced lung oxidative stress via FOXO3-dependent mechanism. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25905433&form=6&db=m Disruption of SIRT1-mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26236580&form=6&db=m Sirtuin 1 and aging theory for chronic obstructive pulmonary disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26336440&form=6&db=m Sirtuin gene polymorphisms are associated with chronic obstructive pulmonary disease in patients in Mu?la province. causal interaction,diagnostic usage,unassigned 4,1,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27784320&form=6&db=m Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28588027&form=6&db=m Exogenous neutrophil elastase enters bronchial epithelial cells and suppresses cigarette smoke extract-induced heme oxygenase-1 by cleaving sirtuin 1. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29861836&form=6&db=m SIRT1 Activity in Peripheral Blood Mononuclear Cells Correlates with Altered Lung Function in Patients with Chronic Obstructive Pulmonary Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29976774&form=6&db=m A highly significant association between Cathepsin S gene polymorphisms rs12068264 and chronic obstructive pulmonary disease susceptibility in Han Chinese population. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29990691&form=6&db=m Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1? in rats with COPD. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31242482&form=6&db=m Erythromycin Regulates Cigarette Smoke-Induced Proinflammatory Mediator Release Through Sirtuin 1-Nuclear Factor ?B Axis in Macrophages and Mice Lungs. causal interaction,unassigned 4,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32057805&form=6&db=m Senotherapy: A New Horizon for COPD Therapy. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33005288&form=6&db=m Sirtuin 3 Inhibits Airway Epithelial Mitochondrial Oxidative Stress in Cigarette Smoke-Induced COPD. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33762567&form=6&db=m Correlations of Silent Information Regulator of Transcription 1 (SIRT1) Expression, Inflammatory Factors, and Oxidative Stress with Pulmonary Function in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD). causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 2.3.1.286 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34040365&form=6&db=m Aerobic Exercise Alleviates Inflammation, Oxidative Stress, and Apoptosis in Mice with Chronic Obstructive Pulmonary Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 2.3.1.286 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27522058&form=6&db=m Sirtuin 3 Deregulation Promotes Pulmonary Fibrosis. causal interaction,unassigned 4,0 2.3.1.286 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27815257&form=6&db=m SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage. causal interaction,unassigned 4,0 2.3.1.286 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28273432&form=6&db=m p53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28385812&form=6&db=m Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.286 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28800254&form=6&db=m SIRT1 Protects Against Systemic Sclerosis-related Pulmonary Fibrosis by Decreasing Pro-inflammatory and Pro-fibrotic Processes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32139663&form=6&db=m Sirt1 antisense long non-coding RNA attenuates pulmonary fibrosis through sirt1-mediated epithelial-mesenchymal transition. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32630842&form=6&db=m CMH-Small Molecule Docks into SIRT1, Elicits Human IPF-Lung Fibroblast Cell Death, Inhibits Ku70-deacetylation, FLIP and Experimental Pulmonary Fibrosis. ongoing research,unassigned 4,0 2.3.1.286 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34040365&form=6&db=m Aerobic Exercise Alleviates Inflammation, Oxidative Stress, and Apoptosis in Mice with Chronic Obstructive Pulmonary Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 2.3.1.286 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22706671&form=6&db=m Resveratrol-poor Red Wines Modulate SIRT1 in Human Renal Cells. ongoing research,unassigned 4,0 2.3.1.286 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26022003&form=6&db=m Activation of Sirtuin-1 Promotes Renal Fibroblast Activation and Aggravates Renal Fibrogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29845208&form=6&db=m Glucagon?like peptide?1 protects mouse podocytes against high glucose?induced apoptosis, and suppresses reactive oxygen species production and proinflammatory cytokine secretion, through sirtuin 1 activation in vitro. causal interaction,unassigned 4,0 2.3.1.286 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33969611&form=6&db=m Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway. therapeutic application,unassigned 4,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23159776&form=6&db=m Poly(ADP-ribose) polymerase inhibition prevents reactive oxygen species induced inhibition of aldehyde dehydrogenase2 activity. therapeutic application,unassigned 4,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23880291&form=6&db=m SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury. causal interaction,unassigned 4,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24379901&form=6&db=m Renal protective effects of resveratrol. causal interaction,unassigned 4,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24466304&form=6&db=m Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26122034&form=6&db=m SIRT1 as a promising novel therapeutic target for myocardial ischemia reperfusion injury and cardiometabolic disease. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27270300&form=6&db=m SIRT1 activation by pterostilbene attenuates the skeletal muscle oxidative stress injury and mitochondrial dysfunction induced by ischemia reperfusion injury. causal interaction,unassigned 4,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28271186&form=6&db=m SUV39H1 mediated SIRT1 trans-repression contributes to cardiac ischemia-reperfusion injury. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29409011&form=6&db=m Cardiomyocyte Specific Deletion of Sirt1 Gene Sensitizes Myocardium to Ischemia and Reperfusion Injury. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30227330&form=6&db=m SIRT3-mediated cardiac remodeling/repair following myocardial infarction. causal interaction,unassigned 4,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31291416&form=6&db=m Serum Sirtuin 1, 3 and 6 Levels in Acute Myocardial Infarction Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31715188&form=6&db=m Exploring the role of orexin B-sirtuin 1-HIF-1? in diabetes-mellitus induced vascular endothelial dysfunction and associated myocardial injury in rats. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31900639&form=6&db=m SIRT1 is required for the neuroprotection of resveratrol on retinal ganglion cells after retinal ischemia-reperfusion injury in mice. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33508434&form=6&db=m SIRT3 as a potential therapeutic target for heart failure. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29363727&form=6&db=m Protective effect of SIRT3 on acute lung injury by increasing manganese superoxide dismutase-mediated antioxidation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23892278&form=6&db=m The role of SIRT1 in ocular aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24036938&form=6&db=m SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-?B pathway. causal interaction,unassigned 4,0 2.3.1.286 Retinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23395551&form=6&db=m SIRT1 activation protects against autoimmune T cell-driven retinal disease in mice via inhibition of IL-2/Stat5 signaling. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Retinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33174070&form=6&db=m The role of sirt1 in the retinal ganglion cells cultured by high glucose. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,3 2.3.1.286 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29062766&form=6&db=m The reason for the amelioration of N-methyl-N-nitrosourea-induced retinitis pigmentosa in rats by hydrogen-rich saline. ongoing research,unassigned 4,0 2.3.1.286 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17620057&form=6&db=m Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34270373&form=6&db=m Angiotensin II-induced overexpression of sirtuin 1 contributes to enhanced expression of Gi? proteins and hyperproliferation of vascular smooth muscle cells. causal interaction,unassigned 4,0 2.3.1.286 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26273643&form=6&db=m Regulation of Cell Cycle Regulators by SIRT1 Contributes to Resveratrol-Mediated Prevention of Pulmonary Arterial Hypertension. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Rift Valley Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31289184&form=6&db=m Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Sarcoma, Alveolar Soft Part http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Sarcoma, Clear Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29150734&form=6&db=m The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Sarcoma, Synovial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25333348&form=6&db=m Sirtuin 1 activation enhances the PGC-1?/mitochondrial antioxidant system pathway in status epilepticus. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.3.1.286 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26945677&form=6&db=m Targeting of microRNA-199a-5p protects against pilocarpine-induced status epilepticus and seizure damage via SIRT1-p53 cascade. diagnostic usage,ongoing research,unassigned 4,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21245135&form=6&db=m NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin Tolerance. ongoing research,unassigned 4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24573134&form=6&db=m Interferon ? protects against lethal endotoxic and septic shock through SIRT1 upregulation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25659903&form=6&db=m Sirt1 restrains lung inflammasome activation in a murine model of sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26641650&form=6&db=m Sirt1 Activation Markedly Alters Transcription Profiles and Improves Outcome in Experimental Sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26974318&form=6&db=m PHARMACOLOGICAL SIRT1 ACTIVATION IMPROVES MORTALITY AND MARKEDLY ALTERS TRANSCRIPTIONAL PROFILES THAT ACCOMPANY EXPERIMENTAL SEPSIS. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28461090&form=6&db=m NAD(+) dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29078895&form=6&db=m SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29277325&form=6&db=m SIRT1 regulates inflammation response of macrophages in sepsis mediated by long noncoding RNA. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29867921&form=6&db=m Acetylation-Dependent Regulation of Notch Signaling in Macrophages by SIRT1 Affects Sepsis Development. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30379096&form=6&db=m SIRT1-mediated HMGB1 deacetylation suppresses sepsis-associated acute kidney injury. ongoing research,unassigned 4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30533222&form=6&db=m Emerging Evidence concerning the Role of Sirtuins in Sepsis. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30707864&form=6&db=m [Role of deacetylase sirtuins in sepsis: beneficial or harmful?] causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31099043&form=6&db=m MCPIP1 alleviated lipopolysaccharide-induced liver injury by regulating SIRT1 via modulation of microRNA-9. causal interaction,unassigned 4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31201798&form=6&db=m Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31282985&form=6&db=m Research progress on SIRT1 and sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31393272&form=6&db=m SIRT1 Mediates Septic Cardiomyopathy in a Murine Model of Polymicrobial Sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31641228&form=6&db=m Polydatin protects against lipopolysaccharide-induced endothelial barrier disruption via SIRT3 activation. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31844680&form=6&db=m MicroRNA-181a-5p Regulates Inflammatory Response of Macrophages in Sepsis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32394287&form=6&db=m Polydatin Alleviates Septic Myocardial Injury by Promoting SIRT6-Mediated Autophagy. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32526680&form=6&db=m Sirt3 is a novel target to treat sepsis induced myocardial dysfunction by acetylated modulation of critical enzymes within cardiac tricarboxylic acid cycle. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32692207&form=6&db=m The clinical significance of the SIRT2 expression level in the early stage of sepsis patients. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33058411&form=6&db=m Inhibition of miR-181a attenuates sepsis-induced inflammation and apoptosis by activating Nrf2 and inhibiting NF-?B pathways via targeting SIRT1. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33263643&form=6&db=m Clinical significance of sirtuin 1 level in sepsis: correlation with disease risk, severity, and mortality risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33368409&form=6&db=m Ethanol Exposure Attenuates Immune Response in Sepsis via Sirtuin 2 Expression. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34249270&form=6&db=m Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.286 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24573134&form=6&db=m Interferon ? protects against lethal endotoxic and septic shock through SIRT1 upregulation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28894448&form=6&db=m Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32692207&form=6&db=m The clinical significance of the SIRT2 expression level in the early stage of sepsis patients. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.286 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26499368&form=6&db=m Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase, Sirt1. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17180656&form=6&db=m Strong expression of a longevity-related protein, SIRT1, in Bowen's disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24438005&form=6&db=m Mammalian SIRT2 inhibits keratin 19 expression and is a tumor suppressor in skin. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24726431&form=6&db=m SIRT1 Inhibition Restores Apoptotic Sensitivity in p53-Mutated Human Keratinocytes. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24814870&form=6&db=m SIRT2 as a new player in epigenetic programming of keratinocyte differentiation and a candidate tumor suppressor. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26310895&form=6&db=m Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.3.1.286 Soft Tissue Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Solitary Fibrous Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28193684&form=6&db=m An Agonist of the Protective Factor SIRT1 Improves Functional Recovery and Promotes Neuronal Survival by Attenuating Inflammation after Spinal Cord Injury. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014276&form=6&db=m The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.286 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34171408&form=6&db=m The Serum SIRT1 Protein is Associated with the Severity of Injury and Neurological Recovery in Mice with Traumatic Spinal Cord Injury. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.286 Spinal Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22152608&form=6&db=m Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.3.1.286 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23453030&form=6&db=m SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23562596&form=6&db=m Identification of novel SIRT3 inhibitor scaffolds by virtual screening. causal interaction,unassigned 4,0 2.3.1.286 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23881456&form=6&db=m Growth Inhibition and Apoptosis-Inducing Effects of Cudraflavone B in Human Oral Cancer Cells via MAPK, NF-?B, and SIRT1 Signaling Pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25946975&form=6&db=m Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26299580&form=6&db=m Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26722027&form=6&db=m A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29050728&form=6&db=m SIRT1 acts as a potential tumor suppressor in oral squamous cell carcinoma. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31931863&form=6&db=m DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing-a possible predictive biomarker for malignant transformation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,2 2.3.1.286 ST Elevation Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29444200&form=6&db=m Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Staphylococcal Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28894448&form=6&db=m Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15486319&form=6&db=m Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24712640&form=6&db=m SIRT2 knockdown increases basal autophagy and prevents post-slippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25798752&form=6&db=m SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26439987&form=6&db=m MicroRNA-212 negatively regulates starvation induced autophagy in prostate cancer cells by inhibiting SIRT1 and is a modulator of angiogenesis and cellular senescence. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29078895&form=6&db=m SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31016257&form=6&db=m Sir2D, a Sirtuin family protein, regulates adenylate cyclase A expression through interaction with the MybB transcription factor early in Dictyostelium development upon starvation. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25333348&form=6&db=m Sirtuin 1 activation enhances the PGC-1?/mitochondrial antioxidant system pathway in status epilepticus. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.3.1.286 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31340436&form=6&db=m Sirtuin 1 Regulates Mitochondrial Biogenesis and Provides an Endogenous Neuroprotective Mechanism Against Seizure-Induced Neuronal Cell Death in the Hippocampus Following Status Epilepticus. causal interaction,unassigned 4,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19509139&form=6&db=m Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24287180&form=6&db=m Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24322174&form=6&db=m SIRT3 Expression as a Biomarker for Better Prognosis in Gastric Cancer. diagnostic usage,therapeutic application,unassigned 4,2,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25033286&form=6&db=m Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25146318&form=6&db=m SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25664004&form=6&db=m SIRT1 counteracted the activation of STAT3 and NF-?B to repress the gastric cancer growth. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26131100&form=6&db=m SIRT3 inhibits cell proliferation in human gastric cancer through down-regulation of Notch-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27483432&form=6&db=m The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29693338&form=6&db=m Sirt1 Gene Expression and Gastric Epithelial Cells Tumor Stage in Patients with Helicobacter pylori Infection causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30710340&form=6&db=m SIRT1 inhibits gastric cancer proliferation and metastasis via STAT3/MMP-13 signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30945643&form=6&db=m Upregulation of SIRT1 gene in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31273630&form=6&db=m Altered Expression of CD44, SIRT1, CXCR4, miR-21, miR-34a, and miR-451 Genes in MKN-45 Cell Line After Docetaxel Treatment. ongoing research,unassigned 4,0 2.3.1.286 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34411362&form=6&db=m Jaridon 6, a new diterpene from Rabdosia rubescens (Hemsl.) Hara, can display anti-gastric cancer resistance by inhibiting SIRT1 and inducing autophagy. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18537630&form=6&db=m Resveratrol and ischemic preconditioning in the brain. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23600725&form=6&db=m Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24323420&form=6&db=m SIRT1 regulation modulates stroke outcome. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25433241&form=6&db=m SIRT3 protects cells from hypoxia via PGC-1?- and MnSOD-dependent pathways. ongoing research,unassigned 4,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25981395&form=6&db=m Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26219598&form=6&db=m Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26477463&form=6&db=m Sirtuins: a possible clinical implication in cardio- and cerebro- vascular systems. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26639783&form=6&db=m Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28527875&form=6&db=m Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29444200&form=6&db=m Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29777578&form=6&db=m Sirt3 deficiency impairs neurovascular recovery in ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30519156&form=6&db=m The Role of Sirt1 in Ischemic Stroke: Pathogenesis and Therapeutic Strategies. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32912518&form=6&db=m Localization and Expression of Sirtuins 1, 2, 6 and Plasticity-Related Proteins in the Recovery Period after a Photothrombotic Stroke in Mice. ongoing research,unassigned 4,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33507417&form=6&db=m Plasma levels of sirtuin-1 in patients with cerebrovascular stroke. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33616302&form=6&db=m Overexpression of sirtuin 2 and its association with prognosis in acute ischemic stroke patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.286 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33877561&form=6&db=m Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27735947&form=6&db=m Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2 2.3.1.286 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29039533&form=6&db=m SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.3.1.286 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30048156&form=6&db=m Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll-like receptor 4 signaling pathway. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32922930&form=6&db=m SIRT3 protects against early brain injury following subarachnoid hemorrhage via promoting mitochondrial fusion in an AMPK dependent manner. therapeutic application,unassigned 4,0 2.3.1.286 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29226865&form=6&db=m SIRT1 Deacetylates SC35 and Suppresses Its Function in Tau Exon 10 Inclusion. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30243024&form=6&db=m Sirt1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32310828&form=6&db=m SIRT1 regulates O-GlcNAcylation of tau through OGT. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20978007&form=6&db=m Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23259556&form=6&db=m SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27275930&form=6&db=m SIRT1 prevents pulmonary thrombus formation induced by arachidonic acid via downregulation of PAF receptor expression in platelets. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.286 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27965959&form=6&db=m A Novel Antithrombotic Mechanism Mediated by the Receptors of the Kallikrein/Kinin and Renin-Angiotensin Systems. causal interaction,unassigned 4,0 2.3.1.286 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29236713&form=6&db=m Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29444200&form=6&db=m Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30546314&form=6&db=m Indoxyl Sulfate Promotes Arterial Thrombosis in Rat Model via Increased Levels of Complex TF/VII, PAI-1, Platelet Activation as Well as Decreased Contents of SIRT1 and SIRT3. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 2.3.1.286 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32712319&form=6&db=m Novel anti-thrombotic mechanisms mediated by Mas receptor as result of balanced activities between the kallikrein/kinin and the renin-angiotensin systems. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23898059&form=6&db=m Nicotinamide phosphoribosyltransferase and SIRT3 expression are increased in well-differentiated thyroid carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30271381&form=6&db=m Vitamin D, FOXO3a, and Sirtuin1 in Hashimoto's Thyroiditis and Differentiated Thyroid Cancer. ongoing research,unassigned 4,0 2.3.1.286 Thyroid Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27245255&form=6&db=m Association between functional SIRT1 polymorphisms and the clinical characteristics of patients with autoimmune thyroid disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 2.3.1.286 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22986535&form=6&db=m SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23898059&form=6&db=m Nicotinamide phosphoribosyltransferase and SIRT3 expression are increased in well-differentiated thyroid carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29207181&form=6&db=m Function of miR-212 as a tumor suppressor in thyroid cancer by targeting SIRT1. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.3.1.286 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31288899&form=6&db=m MicroRNA-1225-5p inhibits the development and progression of thyroid cancer via targeting sirtuin 3. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.3.1.286 Tongue Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30656603&form=6&db=m Sirtuin 3 inhibition induces mitochondrial stress in tongue cancer by targeting mitochondrial fission and the JNK-Fis1 biological axis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.286 Trauma, Nervous System http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24323420&form=6&db=m SIRT1 regulation modulates stroke outcome. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Trigeminal Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34421312&form=6&db=m Puerarin Attenuates Complete Freund's Adjuvant-Induced Trigeminal Neuralgia and Inflammation in a Mouse Model via Sirt1-Mediated TGF-?1/Smad3 Inhibition. ongoing research,unassigned 4,0 2.3.1.286 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22661383&form=6&db=m Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.3.1.286 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26004371&form=6&db=m Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26515337&form=6&db=m SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.286 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26585892&form=6&db=m Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27277416&form=6&db=m Expression of FOXM1 and related proteins in breast cancer molecular subtypes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 2.3.1.286 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31404596&form=6&db=m Structure-based identification of novel sirtuin inhibitors against triple negative breast cancer: An in silico and in vitro study. therapeutic application,unassigned 4,0 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26135889&form=6&db=m Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30774023&form=6&db=m SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 2.3.1.286 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33373810&form=6&db=m Sirt1 activation negatively regulates overt apoptosis in Mtb-infected macrophage through Bax. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.286 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32037392&form=6&db=m Ginsenoside Rg1 Inhibits Cell Proliferation and Induces Markers of Cell Senescence in CD34+CD38- Leukemia Stem Cells Derived from KG1? Acute Myeloid Leukemia Cells by Activating the Sirtuin 1 (SIRT1)/Tuberous Sclerosis Complex 2 (TSC2) Signaling Pathway. diagnostic usage,ongoing research,unassigned 4,4,0 2.3.1.286 udp-3-o-acyl-n-acetylglucosamine deacetylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24917678&form=6&db=m Stoichiometry of site-specific lysine acetylation in an entire proteome. causal interaction,unassigned 4,0 2.3.1.286 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24379901&form=6&db=m Renal protective effects of resveratrol. causal interaction,unassigned 4,0 2.3.1.286 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26022003&form=6&db=m Activation of Sirtuin-1 Promotes Renal Fibroblast Activation and Aggravates Renal Fibrogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.3.1.286 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27659793&form=6&db=m Downregulation of angiotensin type 1 receptor and nuclear factor-?B by sirtuin 1 contributes to renoprotection in unilateral ureteral obstruction. causal interaction,unassigned 4,0 2.3.1.286 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32802201&form=6&db=m Exosomes derived from GDNF-modified human adipose mesenchymal stem cells ameliorate peritubular capillary loss in tubulointerstitial fibrosis by activating the SIRT1/eNOS signaling pathway. ongoing research,unassigned 4,0 2.3.1.286 Urethral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29614506&form=6&db=m Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2. diagnostic usage,ongoing research,unassigned 4,4,0 2.3.1.286 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22089141&form=6&db=m HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 2.3.1.286 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30868406&form=6&db=m SIRT1 promotes GLUT1 expression and bladder cancer progression via regulation of glucose uptake. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25469273&form=6&db=m Sirtuin1 expression predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.3.1.286 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28498637&form=6&db=m ?2-AR activation induces chemoresistance by modulating p53 acetylation through upregulating Sirt1 in cervical cancer cells. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28776959&form=6&db=m Development of Substrate-Derived Sirtuin Inhibitors with Potential Anticancer Activity. therapeutic application,unassigned 4,0 2.3.1.286 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29808798&form=6&db=m Knockdown of SIRT1 inhibits proliferation and promotes apoptosis of paclitaxel-resistant human cervical cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30547809&form=6&db=m The PIK3CA E542K and E545K mutations promote glycolysis and proliferation via induction of the ?-catenin/SIRT3 signaling pathway in cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.286 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32176025&form=6&db=m SIRT2 expression exhibits potential to serve as a biomarker for disease surveillance and prognosis in the management of cervical cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.3.1.286 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32426286&form=6&db=m Sirtuin 1 Inhibiting Thiocyanates (S1th)-A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.286 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33165440&form=6&db=m Effect of the SIRT3-AMPK/PPAR pathway on invasion and migration of cervical cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33649834&form=6&db=m SIRT1 and gynecological malignancies (Review). causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Uterine Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32388637&form=6&db=m Sirtuin1 expression and survival in endometrial and clear-cell uterine cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.286 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23395551&form=6&db=m SIRT1 activation protects against autoimmune T cell-driven retinal disease in mice via inhibition of IL-2/Stat5 signaling. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23892278&form=6&db=m The role of SIRT1 in ocular aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Varicocele http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31696601&form=6&db=m Seminal SIRT1-oxidative stress relationship in infertile oligoasthenoteratozoospermic men with varicocele after its surgical repair. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0 2.3.1.286 Vascular Calcification http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22133824&form=6&db=m [Bone and calcium update; diagnosis and therapy of bone metabolism disease update. Regulatory Mechanism of Mammalian Sirtuin SIRT1 in Vascular calcification: impact of vascular smooth muscle cell senescence]. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.286 Vascular Calcification http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30696833&form=6&db=m Suppression of SIRT1 in Diabetic Conditions Induces Osteogenic Differentiation of Human Vascular Smooth Muscle Cells via RUNX2 Signalling. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Vascular Calcification http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32402066&form=6&db=m Loss of SIRT1 in diabetes accelerates DNA damage induced vascular calcification. causal interaction,unassigned 4,0 2.3.1.286 Vascular Calcification http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33969611&form=6&db=m Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway. therapeutic application,unassigned 4,0 2.3.1.286 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21474819&form=6&db=m SIRT1 Acts as a Modulator of Neointima Formation Following Vascular Injury in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.3.1.286 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22934845&form=6&db=m SIRT1 as a Novel Potential Treatment Target for Vascular Aging and Age-related Vascular Diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31572218&form=6&db=m The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31704100&form=6&db=m CO ameliorates endothelial senescence induced by 5-fluorouracil through SIRT1 activation. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34028177&form=6&db=m The role of SIRT2 in vascular-related and heart-related diseases: A review. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.286 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21474819&form=6&db=m SIRT1 Acts as a Modulator of Neointima Formation Following Vascular Injury in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.3.1.286 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30484407&form=6&db=m Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer's Disease. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Venous Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29236713&form=6&db=m Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.286 Ventricular Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31464387&form=6&db=m Mitochondrial Hyperacetylation in the Failing Hearts of Obese Patients Mediated Partly by a Reduction in SIRT3: The Involvement of the Mitochondrial Permeability Transition Pore. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 2.3.1.286 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31092575&form=6&db=m SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to Vesicular Stomatitis Virus Oncolysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21567102&form=6&db=m Expression and role of SIRT1 in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.286 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22087287&form=6&db=m Involvement of FOXO transcription factors, TRAIL-FasL/Fas, and sirtuin proteins family in canine coronavirus type II-induced apoptosis. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22730114&form=6&db=m Sirtuin activators and inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26491165&form=6&db=m Intricate Roles of Mammalian Sirtuins in Defense against Viral Pathogens. ongoing research,therapeutic application,unassigned 2,4,0 2.3.1.286 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26865910&form=6&db=m Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.286 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27153347&form=6&db=m How much successful are the medicinal chemists in modulation of SIRT1: A critical review. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.286 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32823491&form=6&db=m Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.3.1.286 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34060486&form=6&db=m Histone deficiency and accelerated replication stress in T cell aging. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.286 Vitiligo http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31037127&form=6&db=m SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.286 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23332867&form=6&db=m Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.3.1.286 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21149730&form=6&db=m Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0