2.3.1.12 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4004169&form=6&db=m An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 2.3.1.12 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3049806&form=6&db=m Autoantibodies of primary biliary cirrhosis recognize dihydrolipoamide acetyltransferase and inhibit enzyme function. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.12 Bile Duct Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12108679&form=6&db=m Molecular cloning, and characterization and expression of dihydrolipoamide acetyltransferase component of murine pyruvate dehydrogenase complex in bile duct cancer cells. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.12 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7519986&form=6&db=m Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis. Molecular mimicry of trifluoroacetyl-lysine by lipoic acid. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1370237&form=6&db=m Membrane dihydrolipoamide acetyltransferase (E2) on human biliary epithelial cells in primary biliary cirrhosis. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1714873&form=6&db=m Distribution of dihydrolipoamide acetyltransferase (E2) in the liver and portal lymph nodes of patients with primary biliary cirrhosis: an immunohistochemical study. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1729364&form=6&db=m A lipoyl synthetic octadecapeptide of dihydrolipoamide acetyltransferase specifically recognized by anti-M2 autoantibodies in primary biliary cirrhosis. causal interaction,diagnostic usage,unassigned 1,3,0 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2187198&form=6&db=m Reactivity of primary biliary cirrhosis sera with Escherichia coli dihydrolipoamide acetyltransferase (E2p): characterization of the main immunogenic region. unassigned - 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2455013&form=6&db=m The autoepitope of the 74-kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase. unassigned - 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2473022&form=6&db=m Antimitochondrial autoantibodies in primary biliary cirrhosis recognize cross-reactive epitope(s) on protein X and dihydrolipoamide acetyltransferase of pyruvate dehydrogenase complex. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2920998&form=6&db=m Immunization of experimental animals with dihydrolipoamide acetyltransferase, as a purified recombinant polypeptide, generates mitochondrial antibodies but not primary biliary cirrhosis. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,2,0 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3049806&form=6&db=m Autoantibodies of primary biliary cirrhosis recognize dihydrolipoamide acetyltransferase and inhibit enzyme function. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3174635&form=6&db=m Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8102256&form=6&db=m Chromosome localization and RFLP analysis of PDC-E2: the major autoantigen of primary biliary cirrhosis. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8133065&form=6&db=m Nucleotide sequence analysis of natural and combinatorial anti-PDC-E2 antibodies in patients with primary biliary cirrhosis. Recapitulating immune selection with molecular biology. unassigned - 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8188168&form=6&db=m Distribution of pyruvate dehydrogenase dihydrolipoamide acetyltransferase (PDC-E2) and another mitochondrial marker in salivary gland and biliary epithelium from patients with primary biliary cirrhosis. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8336525&form=6&db=m Antibody to two forms of dihydrolipoamide acetyltransferase (PDC-E2) in primary biliary cirrhosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8460168&form=6&db=m Combinatorial autoantibodies to dihydrolipoamide acetyltransferase, the major autoantigen of primary biliary cirrhosis. diagnostic usage,ongoing research,unassigned 3,1,0 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8855289&form=6&db=m Random phage mimotopes recognized by monoclonal antibodies against the pyruvate dehydrogenase complex-E2 (PDC-E2). diagnostic usage,unassigned 3,0 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9650094&form=6&db=m Natural and disease associated autoantibodies to the autoantigen, dihydrolipoamide acetyltransferase, recognise different epitopes. ongoing research,unassigned 3,0 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10418928&form=6&db=m Immunopathology of primary biliary cirrhosis. unassigned - 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12108679&form=6&db=m Molecular cloning, and characterization and expression of dihydrolipoamide acetyltransferase component of murine pyruvate dehydrogenase complex in bile duct cancer cells. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.12 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14708897&form=6&db=m Epitope mapping on E1alpha subunit of pyruvate dehydrogenase complex with autoantibodies of patients with primary biliary cirrhosis. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 2.3.1.12 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2920998&form=6&db=m Immunization of experimental animals with dihydrolipoamide acetyltransferase, as a purified recombinant polypeptide, generates mitochondrial antibodies but not primary biliary cirrhosis. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,2,0 2.3.1.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12108679&form=6&db=m Molecular cloning, and characterization and expression of dihydrolipoamide acetyltransferase component of murine pyruvate dehydrogenase complex in bile duct cancer cells. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.12 pyruvate dehydrogenase (nadp+) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2684741&form=6&db=m Partial complementation of pyruvate dehydrogenase deficiency by independently expressed lipoyl and catalytic domains of the dihydrolipoamide acetyltransferase component. unassigned - 2.3.1.12 pyruvate dehydrogenase (nadp+) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16049940&form=6&db=m Clinical and genetic spectrum of pyruvate dehydrogenase deficiency: dihydrolipoamide acetyltransferase (E2) deficiency. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 2.3.1.12 Pyruvate Dehydrogenase Complex Deficiency Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2684741&form=6&db=m Partial complementation of pyruvate dehydrogenase deficiency by independently expressed lipoyl and catalytic domains of the dihydrolipoamide acetyltransferase component. unassigned - 2.3.1.12 Pyruvate Dehydrogenase Complex Deficiency Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16049940&form=6&db=m Clinical and genetic spectrum of pyruvate dehydrogenase deficiency: dihydrolipoamide acetyltransferase (E2) deficiency. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1