1.6.5.5 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16219914&form=6&db=m Role of deadenylation and AUF1 binding in the pH-responsive stabilization of glutaminase mRNA. causal interaction,ongoing research,unassigned 4,2,0 1.6.5.5 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19657324&form=6&db=m Zeta-crystallin mediates the acid pH-induced increase of BSC1 cotransporter mRNA stability. causal interaction,unassigned 1,0 1.6.5.5 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19752863&form=6&db=m Zeta-crystallin: a tale of two cells. ongoing research,unassigned 1,0 1.6.5.5 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9581869&form=6&db=m Mammalian protein homologous to VAT-1 of Torpedo californica: isolation from Ehrlich ascites tumor cells, biochemical characterization, and organization of its gene. diagnostic usage,ongoing research,unassigned 3,4,0 1.6.5.5 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2107967&form=6&db=m Long term effects of benzo(a)pyrene on the activity of NAD(P)H:quinone reductase in the forestomach and glandular stomach of ICR/Ha mice. ongoing research,unassigned 2,0 1.6.5.5 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9406240&form=6&db=m DT-diaphorase: possible roles in cancer chemotherapy and carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 1.6.5.5 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1901207&form=6&db=m The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 1.6.5.5 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2480794&form=6&db=m Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in Walker cells. ongoing research,unassigned 2,0 1.6.5.5 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8615901&form=6&db=m Role of NAD(P)H:quinone oxidoreductase (DT-diaphorase) in cytotoxicity and induction of DNA damage by streptonigrin. diagnostic usage,ongoing research,unassigned 1,2,0 1.6.5.5 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9343371&form=6&db=m The role of NAD(P)H:quinone oxidoreductase in quinone-mediated p21 induction in human colon carcinoma cells. causal interaction,ongoing research,unassigned 1,4,0 1.6.5.5 Carcinoma, Ehrlich Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9581869&form=6&db=m Mammalian protein homologous to VAT-1 of Torpedo californica: isolation from Ehrlich ascites tumor cells, biochemical characterization, and organization of its gene. diagnostic usage,ongoing research,unassigned 3,4,0 1.6.5.5 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1549602&form=6&db=m Rapid detection of inducers of enzymes that protect against carcinogens. ongoing research,unassigned 3,0 1.6.5.5 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2696344&form=6&db=m Mechanisms of induction of enzymes that protect against chemical carcinogenesis. unassigned - 1.6.5.5 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3080750&form=6&db=m Induction of NAD(P)H:quinone reductase in murine hepatoma cells by phenolic antioxidants, azo dyes, and other chemoprotectors: a model system for the study of anticarcinogens. ongoing research,therapeutic application,unassigned 3,1,0 1.6.5.5 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3708758&form=6&db=m 1,2-Dithiol-3-thione analogs: effects on NAD(P)H:quinone reductase and glutathione levels in murine hepatoma cells. ongoing research,unassigned 4,0 1.6.5.5 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7693959&form=6&db=m Direct determination of functional activity of cytochrome P-4501A1 and NADPH DT-diaphorase in hepatoma cell lines using noninvasive scanning laser cytometry. ongoing research,therapeutic application,unassigned 4,1,0 1.6.5.5 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7703353&form=6&db=m Mercurials and dimercaptans: synergism in the induction of chemoprotective enzymes. ongoing research,unassigned 1,0 1.6.5.5 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10998434&form=6&db=m Induction of NADPH:quinone oxidoreductase in murine hepatoma cells by methylsulfinyl isothiocyanates: methyl chain length-activity study. diagnostic usage,ongoing research,unassigned 3,4,0 1.6.5.5 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25820747&form=6&db=m The p53-inducible gene 3 involved in flavonoid-induced cytotoxicity through the reactive oxygen species-mediated mitochondrial apoptotic pathway in human hepatoma cells. ongoing research,therapeutic application,unassigned 4,1,0 1.6.5.5 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1370456&form=6&db=m Identification and characterization of the enzymatic activity of zeta-crystallin from guinea pig lens. A novel NADPH:quinone oxidoreductase. causal interaction,unassigned 3,0 1.6.5.5 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1390943&form=6&db=m A guinea-pig hereditary cataract contains a splice-site deletion in a crystallin gene. unassigned - 1.6.5.5 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1623948&form=6&db=m Mutant zeta-crystallin from guinea-pig hereditary cataracts has altered structural and enzymatic properties. unassigned - 1.6.5.5 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1695576&form=6&db=m The transcripts of zeta-crystallin, a lens protein related to the alcohol dehydrogenase family, are altered in a guinea-pig hereditary cataract. unassigned - 1.6.5.5 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2318275&form=6&db=m Association of hereditary cataracts in strain 13/N guinea-pigs with mutation of the gene for zeta-crystallin. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.6.5.5 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7835889&form=6&db=m Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms. causal interaction,unassigned 3,0 1.6.5.5 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9288453&form=6&db=m On the nature of hereditary cataract in strain 13/N guinea pigs. causal interaction,unassigned 4,0 1.6.5.5 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10930585&form=6&db=m Zeta-crystallin catalyzes the reductive activation of 2,4,6-trinitrotoluene to generate reactive oxygen species: a proposed mechanism for the induction of cataracts. unassigned - 1.6.5.5 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11237687&form=6&db=m Expression of recombinant zeta-crystallin in Escherichia coli with the help of GroEL/ES and its purification. ongoing research,therapeutic application,unassigned 1,1,0 1.6.5.5 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15047705&form=6&db=m NF-kappaB activation by the chemopreventive dithiolethione oltipraz is exerted through stimulation of MEKK3 signaling. therapeutic application,unassigned 2,0 1.6.5.5 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19508442&form=6&db=m Vesicle amine transport protein-1 (VAT-1) is upregulated in glioblastomas and promotes migration. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.6.5.5 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19508442&form=6&db=m Vesicle amine transport protein-1 (VAT-1) is upregulated in glioblastomas and promotes migration. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.6.5.5 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16079999&form=6&db=m Differential regulation of wheat quinone reductases in response to powdery mildew infection. unassigned - 1.6.5.5 Lens Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1390943&form=6&db=m A guinea-pig hereditary cataract contains a splice-site deletion in a crystallin gene. unassigned - 1.6.5.5 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20103721&form=6&db=m {zeta}-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1739405&form=6&db=m Enzymology of the reduction of the potent benzotriazine-di-N-oxide hypoxic cell cytotoxin SR 4233 (WIN 59075) by NAD(P)H: (quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from Walker 256 rat tumour cells. ongoing research,unassigned 2,0 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3084073&form=6&db=m Xenobiotic metabolizing enzymes in genetically and chemically initiated mouse liver tumors. ongoing research,unassigned 2,0 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3115561&form=6&db=m DT-diaphorase in morbidly obese patients. ongoing research,unassigned 2,0 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8221686&form=6&db=m Cigarette smoking is a determinant of DT-diaphorase gene expression in human non-small cell lung carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9406240&form=6&db=m DT-diaphorase: possible roles in cancer chemotherapy and carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9496914&form=6&db=m Differential induction of Cyp1a1, Cyp1b1, Ahd4, and Nmo1 in murine skin tumors and adjacent normal epidermis by ligands of the aryl hydrocarbon receptor. causal interaction,ongoing research,unassigned 4,4,0 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9581869&form=6&db=m Mammalian protein homologous to VAT-1 of Torpedo californica: isolation from Ehrlich ascites tumor cells, biochemical characterization, and organization of its gene. diagnostic usage,ongoing research,unassigned 3,4,0 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10656629&form=6&db=m Role of redox cycling and activation by DT-diaphorase in the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its analogs. causal interaction,ongoing research,unassigned 1,2,0 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10718341&form=6&db=m Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice. unassigned - 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11035253&form=6&db=m Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues. ongoing research,unassigned 4,0 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11040064&form=6&db=m Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo. ongoing research,therapeutic application,unassigned 4,1,0 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11351248&form=6&db=m Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation. therapeutic application,unassigned 3,0 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11600935&form=6&db=m Immunohistochemical localization of NAD(P)H:quinone oxidoreductase in conjunctival melanomas and primary acquired melanosis. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15010841&form=6&db=m Detection of (NAD(P)H:Quinone oxidoreductase-1, EC 1.6.99.2) 609C-->T and 465C-->T polymorphisms in formalin-fixed, paraffin-embedded human tumour tissue using PCR-RFLP. diagnostic usage,ongoing research,unassigned 1,2,0 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15566399&form=6&db=m Nitroreductase: a prodrug-activating enzyme for cancer gene therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,4 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15746574&form=6&db=m Cytotoxicity of RH1: NAD(P)H:quinone acceptor oxidoreductase (NQO1)-independent oxidative stress and apoptosis induction. causal interaction,therapeutic application,unassigned 3,2,0 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16010345&form=6&db=m Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. unassigned - 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23233739&form=6&db=m Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer. diagnostic usage,therapeutic application,unassigned 3,1,0 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26462257&form=6&db=m Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone. ongoing research,therapeutic application,unassigned 2,1,0 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31403069&form=6&db=m Neocarzilin A Is a Potent Inhibitor of Cancer Cell Motility Targeting VAT-1 Controlled Pathways. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,3,0 1.6.5.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31563996&form=6&db=m Zeta-crystallin: a moonlighting player in cancer. unassigned - 1.6.5.5 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14500388&form=6&db=m Dicumarol inhibition of NADPH:quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism. causal interaction,therapeutic application,unassigned 2,3,0 1.6.5.5 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9496914&form=6&db=m Differential induction of Cyp1a1, Cyp1b1, Ahd4, and Nmo1 in murine skin tumors and adjacent normal epidermis by ligands of the aryl hydrocarbon receptor. causal interaction,ongoing research,unassigned 4,4,0 1.6.5.5 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2856069&form=6&db=m The murine aromatic hydrocarbon responsiveness locus: a comparison of receptor levels and several inducible enzyme activities among recombinant inbred lines. ongoing research,therapeutic application,unassigned 3,1,0 1.6.5.5 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20103721&form=6&db=m {zeta}-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 1.6.5.5 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21394740&form=6&db=m VAT-1 is a novel pathogenic factor of progressive benign prostatic hyperplasia. causal interaction,ongoing research,unassigned 4,1,0 1.6.5.5 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21394740&form=6&db=m VAT-1 is a novel pathogenic factor of progressive benign prostatic hyperplasia. causal interaction,ongoing research,unassigned 4,1,0 1.6.5.5 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26462257&form=6&db=m Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone. ongoing research,therapeutic application,unassigned 2,1,0 1.6.5.5 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11710826&form=6&db=m A novel strategy for NQO1 (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) mediated therapy of bladder cancer based on the pharmacological properties of EO9. therapeutic application,unassigned 4,0