1.5.5.2 22q11 Deletion Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18989458&form=6&db=m Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function. causal interaction,therapeutic application,unassigned 2,1,0 1.5.5.2 22q11 Deletion Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26068888&form=6&db=m PRODH rs450046 and proline x COMT Valš?? Met interaction effects on intelligence and startle in adults with 22q11 deletion syndrome. ongoing research,therapeutic application,unassigned 1,1,0 1.5.5.2 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34089390&form=6&db=m N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,2 1.5.5.2 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25184115&form=6&db=m Sources of superoxide/H2O2 during mitochondrial proline oxidation. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 1.5.5.2 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28492237&form=6&db=m Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 1.5.5.2 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28942439&form=6&db=m Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX-Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model. ongoing research,unassigned 4,0 1.5.5.2 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29568391&form=6&db=m Proline oxidase silencing induces proline-dependent pro-survival pathways in MCF-7 cells. ongoing research,unassigned 3,0 1.5.5.2 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31189611&form=6&db=m Targeting Mitochondrial Proline Dehydrogenase with a Suicide Inhibitor to Exploit Synthetic Lethal Interactions with p53 Upregulation and Glutaminase Inhibition. causal interaction,therapeutic application,unassigned 3,4,0 1.5.5.2 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31559416&form=6&db=m HDAC inhibitors induce proline dehydrogenase (POX) transcription and anti-apoptotic autophagy in triple negative breast cancer. causal interaction,unassigned 2,0 1.5.5.2 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22886911&form=6&db=m Proline dehydrogenase (oxidase) in cancer. causal interaction,therapeutic application,unassigned 4,1,0 1.5.5.2 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31559416&form=6&db=m HDAC inhibitors induce proline dehydrogenase (POX) transcription and anti-apoptotic autophagy in triple negative breast cancer. causal interaction,unassigned 2,0 1.5.5.2 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31911619&form=6&db=m Cancer progression is mediated by proline catabolism in non-small cell lung cancer. causal interaction,unassigned 4,0 1.5.5.2 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22796327&form=6&db=m Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 1.5.5.2 Catatonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22401837&form=6&db=m Medical and developmental risk factors of catatonia in children and adolescents: A prospective case-control study. unassigned - 1.5.5.2 Coma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22401837&form=6&db=m Medical and developmental risk factors of catatonia in children and adolescents: A prospective case-control study. unassigned - 1.5.5.2 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8776899&form=6&db=m A nuclear gene encoding mitochondrial proline dehydrogenase, an enzyme involved in proline metabolism, is upregulated by proline but downregulated by dehydration in Arabidopsis. unassigned - 1.5.5.2 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9399433&form=6&db=m Regulation of levels of proline as an osmolyte in plants under water stress. causal interaction,unassigned 3,0 1.5.5.2 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12376638&form=6&db=m ACTCAT, a novel cis-acting element for proline- and hypoosmolarity-responsive expression of the ProDH gene encoding proline dehydrogenase in Arabidopsis. causal interaction,therapeutic application,unassigned 1,1,0 1.5.5.2 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16668952&form=6&db=m Effect of Exogenous Abscisic Acid on Proline Dehydrogenase Activity in Maize (Zea mays L.). therapeutic application,unassigned 1,0 1.5.5.2 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20883441&form=6&db=m Expression analysis of proline metabolism-related genes from halophyte Arabis stelleri under osmotic stress conditions. causal interaction,unassigned 3,0 1.5.5.2 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28309193&form=6&db=m Effect of water stress on growth and proline metabolism of Phaseolus vulgaris L. unassigned - 1.5.5.2 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32320942&form=6&db=m Proline metabolic dynamics and implications in drought tolerance of peanut plants. diagnostic usage,unassigned 1,0 1.5.5.2 DiGeorge Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15494707&form=6&db=m Hyperprolinemia is a risk factor for schizoaffective disorder. causal interaction,diagnostic usage,unassigned 3,1,0 1.5.5.2 DiGeorge Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17412540&form=6&db=m Early neurological phenotype in 4 children with biallelic PRODH mutations. unassigned - 1.5.5.2 DiGeorge Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23910792&form=6&db=m Schizophrenia-like neurophysiological abnormalities in 22q11.2 deletion syndrome and their association to COMT and PRODH genotypes. causal interaction,ongoing research,unassigned 2,2,0 1.5.5.2 DiGeorge Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24853458&form=6&db=m Association of COMT and PRODH gene variants with intelligence quotient (IQ) and executive functions in 22q11.2DS subjects. unassigned - 1.5.5.2 DiGeorge Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26978485&form=6&db=m The 22q11 PRODH/DGCR6 deletion is frequent in hyperprolinemic subjects but is not a strong risk factor for ASD. unassigned - 1.5.5.2 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22401837&form=6&db=m Medical and developmental risk factors of catatonia in children and adolescents: A prospective case-control study. unassigned - 1.5.5.2 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18197084&form=6&db=m Type I hyperprolinemia and proline dehydrogenase (PRODH) mutations in four Italian children with epilepsy and mental retardation. causal interaction,unassigned 4,0 1.5.5.2 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30867130&form=6&db=m Exercise Reveals Proline Dehydrogenase as a Potential Target in Heart Failure. causal interaction,therapeutic application,unassigned 4,4,0 1.5.5.2 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11788754&form=6&db=m Altered levels of proline dehydrogenase cause hypersensitivity to proline and its analogs in Arabidopsis. diagnostic usage,unassigned 1,0 1.5.5.2 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26284090&form=6&db=m P5CDH affects the pathways contributing to Pro synthesis after ProDH activation by biotic and abiotic stress conditions. causal interaction,ongoing research,unassigned 1,1,0 1.5.5.2 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27526663&form=6&db=m Differential control and function of Arabidopsis ProDH1 and ProDH2 genes upon infection with biotrophic and necrotrophic pathogens. ongoing research,unassigned 1,0 1.5.5.2 Insomnia, Fatal Familial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22401837&form=6&db=m Medical and developmental risk factors of catatonia in children and adolescents: A prospective case-control study. unassigned - 1.5.5.2 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18197084&form=6&db=m Type I hyperprolinemia and proline dehydrogenase (PRODH) mutations in four Italian children with epilepsy and mental retardation. causal interaction,unassigned 4,0 1.5.5.2 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33646427&form=6&db=m Reprogramming of mitochondrial proline metabolism promotes liver tumorigenesis. unassigned - 1.5.5.2 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31935820&form=6&db=m Proline-Dependent Induction of Apoptosis in Oral Squamous Cell Carcinoma (OSCC)-The Effect of Celecoxib. therapeutic application,unassigned 4,0 1.5.5.2 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33294127&form=6&db=m Metabolomic Analysis of the Ameliorative Effect of Enhanced Proline Metabolism on Hypoxia-Induced Injury in Cardiomyocytes. ongoing research,unassigned 1,0 1.5.5.2 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28492237&form=6&db=m Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 1.5.5.2 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34283310&form=6&db=m Proline dehydrogenase in cancer: apoptosis, autophagy, nutrient dependency and cancer therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,2 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17992665&form=6&db=m Expression signatures in lung cancer reveal a profile for EGFR-mutant tumours and identify selective PIK3CA overexpression by gene amplification. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22201839&form=6&db=m Proline metabolism and cancer. causal interaction,unassigned 2,0 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22593641&form=6&db=m Role of apoptosis-inducing factor, proline dehydrogenase, and NADPH oxidase in apoptosis and oxidative stress. causal interaction,unassigned 1,0 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22615405&form=6&db=m Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC. causal interaction,ongoing research,unassigned 1,2,0 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22796327&form=6&db=m Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22885468&form=6&db=m Proline dehydrogenase (oxidase), a mitochondrial tumor suppressor, and autophagy under the hypoxia microenvironment. causal interaction,unassigned 3,0 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22886911&form=6&db=m Proline dehydrogenase (oxidase) in cancer. causal interaction,therapeutic application,unassigned 4,1,0 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23861960&form=6&db=m P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements. unassigned - 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25184115&form=6&db=m Sources of superoxide/H2O2 during mitochondrial proline oxidation. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27040799&form=6&db=m Prolidase-proline dehydrogenase/proline oxidase-collagen biosynthesis axis as a potential interface of apoptosis/autophagy. causal interaction,unassigned 3,0 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28245795&form=6&db=m In search of druggable targets for GBM amino acid metabolism. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28492237&form=6&db=m Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29648801&form=6&db=m The Proline Cycle As a Potential Cancer Therapy Target. causal interaction,therapeutic application,unassigned 3,4,0 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30545412&form=6&db=m 1-Pyrroline-5-carboxylate released by prostate Cancer cell inhibit T cell proliferation and function by targeting SHP1/cytochrome c oxidoreductase/ROS Axis. causal interaction,unassigned 4,0 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31189611&form=6&db=m Targeting Mitochondrial Proline Dehydrogenase with a Suicide Inhibitor to Exploit Synthetic Lethal Interactions with p53 Upregulation and Glutaminase Inhibition. causal interaction,therapeutic application,unassigned 3,4,0 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31911619&form=6&db=m Cancer progression is mediated by proline catabolism in non-small cell lung cancer. causal interaction,unassigned 4,0 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32159324&form=6&db=m Covalent Modification of the Flavin in Proline Dehydrogenase by Thiazolidine-2-Carboxylate. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32213586&form=6&db=m Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis. causal interaction,unassigned 3,0 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33083024&form=6&db=m The Janus-like role of proline metabolism in cancer. causal interaction,therapeutic application,unassigned 4,3,0 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33818628&form=6&db=m Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy. causal interaction,therapeutic application,unassigned 3,3,0 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34003320&form=6&db=m Structure, biochemistry, and gene expression patterns of the proline biosynthetic enzyme pyrroline-5-carboxylate reductase (PYCR), an emerging cancer therapy target. unassigned - 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34089390&form=6&db=m N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,2 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34283310&form=6&db=m Proline dehydrogenase in cancer: apoptosis, autophagy, nutrient dependency and cancer therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,2 1.5.5.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34542291&form=6&db=m Photoinduced Covalent Irreversible Inactivation of Proline Dehydrogenase by S-Heterocycles. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 1.5.5.2 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24218577&form=6&db=m Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH. causal interaction,diagnostic usage,unassigned 1,3,0 1.5.5.2 Neurologic Manifestations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12217952&form=6&db=m PRODH mutations and hyperprolinemia in a subset of schizophrenic patients. causal interaction,unassigned 3,0 1.5.5.2 proline dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1008803&form=6&db=m Mitochondrial proline dehydrogenase deficiency in hyperprolinemic PRO/Re mice: genetic and enzymatic analyses. causal interaction,unassigned 2,0 1.5.5.2 proline dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16234811&form=6&db=m Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice. causal interaction,therapeutic application,unassigned 3,1,0 1.5.5.2 pyrroline-5-carboxylate reductase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23462603&form=6&db=m Identification of PRODH Mutations in Korean Neonates with Type I Hyperprolinemia. causal interaction,unassigned 4,0 1.5.5.2 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22401837&form=6&db=m Medical and developmental risk factors of catatonia in children and adolescents: A prospective case-control study. unassigned - 1.5.5.2 Sleep Initiation and Maintenance Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22401837&form=6&db=m Medical and developmental risk factors of catatonia in children and adolescents: A prospective case-control study. unassigned - 1.5.5.2 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21278122&form=6&db=m Heterodimers of the Arabidopsis Transcription Factors bZIP1 and bZIP53 Reprogram Amino Acid Metabolism during Low Energy Stress. causal interaction,unassigned 1,0 1.5.5.2 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31559416&form=6&db=m HDAC inhibitors induce proline dehydrogenase (POX) transcription and anti-apoptotic autophagy in triple negative breast cancer. causal interaction,unassigned 2,0 1.5.5.2 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23834473&form=6&db=m Kinetic and Isotopic Characterization of l-Proline Dehydrogenase from Mycobacterium tuberculosis. ongoing research,unassigned 4,0