1.5.3.16 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12827295&form=6&db=m Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 1.5.3.16 Brain Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27037020&form=6&db=m Aggravation of brain infarction through an increase in acrolein production and a decrease in glutathione with aging. unassigned - 1.5.3.16 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26530396&form=6&db=m Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse. causal interaction,unassigned 1,0 1.5.3.16 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16207710&form=6&db=m Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 1.5.3.16 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20946629&form=6&db=m Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm. therapeutic application,unassigned 1,0 1.5.3.16 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17145855&form=6&db=m Tumor necrosis factor-alpha increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis. ongoing research,unassigned 3,0 1.5.3.16 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18302221&form=6&db=m Increased spermine oxidase expression in human prostate cancer and prostatic intraepithelial neoplasia tissues. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 1.5.3.16 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18422650&form=6&db=m Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology. causal interaction,therapeutic application,unassigned 4,3,0 1.5.3.16 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27041578&form=6&db=m Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer. causal interaction,therapeutic application,unassigned 4,1,0 1.5.3.16 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32863742&form=6&db=m The Mechanism of Bacteroides fragilis Toxin Contributes to Colon Cancer Formation. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 1.5.3.16 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12827295&form=6&db=m Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 1.5.3.16 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29923661&form=6&db=m Spermine oxidase is upregulated and promotes tumor growth in hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 1.5.3.16 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29922289&form=6&db=m Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection. causal interaction,ongoing research,unassigned 4,3,0 1.5.3.16 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20127992&form=6&db=m Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity. causal interaction,ongoing research,unassigned 2,1,0 1.5.3.16 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17987291&form=6&db=m Polyamine catabolism in colorectal cancer cells following treatment with oxaliplatin, 5-fluorouracil and N1, N11 diethylnorspermine. therapeutic application,unassigned 3,0 1.5.3.16 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33618627&form=6&db=m The roles of microbial products in the development of colorectal cancer: a review. ongoing research,unassigned 2,0 1.5.3.16 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16554974&form=6&db=m Polyamines in renal failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 1.5.3.16 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31207342&form=6&db=m Spermine oxidase: A promising therapeutic target for neurodegeneration in diabetic retinopathy. therapeutic application,unassigned 4,0 1.5.3.16 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31197571&form=6&db=m Epileptic seizures and oxidative stress in a mouse model over-expressing spermine oxidase. ongoing research,therapeutic application,unassigned 3,1,0 1.5.3.16 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15574757&form=6&db=m Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. causal interaction,unassigned 4,0 1.5.3.16 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27041578&form=6&db=m Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer. causal interaction,therapeutic application,unassigned 4,1,0 1.5.3.16 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16554974&form=6&db=m Polyamines in renal failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 1.5.3.16 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23583682&form=6&db=m Identification of reproduction-related genes and SSR-markers through expressed sequence tags analysis of a monsoon breeding carp rohu, Labeo rohita (Hamilton). unassigned - 1.5.3.16 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17363080&form=6&db=m Chronic sub-lethal oxidative stress by spermine oxidase overactivity induces continuous DNA repair and hypersensitivity to radiation exposure. causal interaction,therapeutic application,unassigned 4,1,0 1.5.3.16 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15574757&form=6&db=m Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. causal interaction,unassigned 4,0 1.5.3.16 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25174398&form=6&db=m Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 1.5.3.16 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26221980&form=6&db=m Cotton polyamine oxidase is required for spermine and camalexin signalling in the defence response to Verticillium dahliae. causal interaction,diagnostic usage,unassigned 2,3,0 1.5.3.16 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29922289&form=6&db=m Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection. causal interaction,ongoing research,unassigned 4,3,0 1.5.3.16 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33618627&form=6&db=m The roles of microbial products in the development of colorectal cancer: a review. ongoing research,unassigned 2,0 1.5.3.16 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16269634&form=6&db=m Polyamine oxidase and acrolein as novel biochemical markers for diagnosis of cerebral stroke. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.5.3.16 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16554974&form=6&db=m Polyamines in renal failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 1.5.3.16 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12827295&form=6&db=m Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 1.5.3.16 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25406264&form=6&db=m Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 1.5.3.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12827295&form=6&db=m Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 1.5.3.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17145855&form=6&db=m Tumor necrosis factor-alpha increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis. ongoing research,unassigned 3,0 1.5.3.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17371265&form=6&db=m Inflammation and polyamine catabolism: the good, the bad and the ugly. therapeutic application,unassigned 1,0 1.5.3.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18302221&form=6&db=m Increased spermine oxidase expression in human prostate cancer and prostatic intraepithelial neoplasia tissues. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 1.5.3.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19685053&form=6&db=m The polyamine analog PG11047 potentiates the antitumor activity of cisplatin and bevacizumab in preclinical models of lung and prostate cancer. ongoing research,unassigned 1,0 1.5.3.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23999645&form=6&db=m Spermine metabolism and radiation-derived reactive oxygen species for future therapeutic implications in cancer: an additive or adaptive response. causal interaction,therapeutic application,unassigned 1,2,0 1.5.3.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24190492&form=6&db=m Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 1.5.3.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29923661&form=6&db=m Spermine oxidase is upregulated and promotes tumor growth in hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 1.5.3.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33618627&form=6&db=m The roles of microbial products in the development of colorectal cancer: a review. ongoing research,unassigned 2,0 1.5.3.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34465810&form=6&db=m Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study. diagnostic usage,ongoing research,unassigned 3,2,0 1.5.3.16 Nephrosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16554974&form=6&db=m Polyamines in renal failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 1.5.3.16 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14764092&form=6&db=m Mouse spermine oxidase gene splice variants. Nuclear subcellular localization of a novel active isoform. diagnostic usage,ongoing research,unassigned 1,4,0 1.5.3.16 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15907589&form=6&db=m Direct oxidative DNA damage, apoptosis and radio sensitivity by spermine oxidase activities in mouse neuroblastoma cells. ongoing research,therapeutic application,unassigned 3,1,0 1.5.3.16 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17363080&form=6&db=m Chronic sub-lethal oxidative stress by spermine oxidase overactivity induces continuous DNA repair and hypersensitivity to radiation exposure. causal interaction,therapeutic application,unassigned 4,1,0 1.5.3.16 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26895301&form=6&db=m HIV-Tat Induces the Nrf2/ARE Pathway through NMDA Receptor-Elicited Spermine Oxidase Activation in Human Neuroblastoma Cells. ongoing research,therapeutic application,unassigned 3,1,0 1.5.3.16 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31545418&form=6&db=m Link between spermine oxidase and apoptosis antagonizing transcription factor: A new pathway in neuroblastoma. unassigned - 1.5.3.16 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252142&form=6&db=m Polyamine catabolism in platinum drug action: Interactions between oxaliplatin and the polyamine analogue N1,N11-diethylnorspermine at the level of spermidine/spermine N1-acetyltransferase. therapeutic application,unassigned 1,0 1.5.3.16 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19425496&form=6&db=m [Methylated analogues of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism] unassigned - 1.5.3.16 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18302221&form=6&db=m Increased spermine oxidase expression in human prostate cancer and prostatic intraepithelial neoplasia tissues. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 1.5.3.16 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18302221&form=6&db=m Increased spermine oxidase expression in human prostate cancer and prostatic intraepithelial neoplasia tissues. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 1.5.3.16 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32132040&form=6&db=m Polyamine Analogues of Propanediamine Series Inhibit Prostate Tumor Cell Growth and Activate the Polyamine Catabolic Pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 1.5.3.16 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20392931&form=6&db=m The Role of Spermidine/Spermine-N1-Acetyltransferase in Endotoxin-Induced Acute Kidney Injury. causal interaction,ongoing research,unassigned 3,3,0 1.5.3.16 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26530396&form=6&db=m Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse. causal interaction,unassigned 1,0 1.5.3.16 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31197571&form=6&db=m Epileptic seizures and oxidative stress in a mouse model over-expressing spermine oxidase. ongoing research,therapeutic application,unassigned 3,1,0 1.5.3.16 Stomach Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28124148&form=6&db=m Human and Helicobacter pylori Interactions Determine the Outcome of Gastric Diseases. causal interaction,unassigned 1,0 1.5.3.16 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15574757&form=6&db=m Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. causal interaction,unassigned 4,0 1.5.3.16 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21839041&form=6&db=m Spermine Oxidase Mediates the Gastric Cancer Risk Associated With Helicobacter pylori CagA. diagnostic usage,ongoing research,unassigned 1,2,0 1.5.3.16 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22555547&form=6&db=m Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk. causal interaction,ongoing research,unassigned 1,2,0 1.5.3.16 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25174398&form=6&db=m Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 1.5.3.16 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27041578&form=6&db=m Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer. causal interaction,therapeutic application,unassigned 4,1,0 1.5.3.16 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32350444&form=6&db=m Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling. causal interaction,therapeutic application,unassigned 3,1,0 1.5.3.16 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18757054&form=6&db=m Acrolein, IL-6 and CRP as markers of silent brain infarction. unassigned - 1.5.3.16 Zika Virus Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30040423&form=6&db=m Polymeric Prodrugs Targeting Polyamine Metabolism Inhibit Zika Virus Replication. unassigned -