1.3.98.3 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25122784&form=6&db=m Equine viperin restricts equine infectious anemia virus replication by inhibiting the production and/or release of viral Gag, Env, and receptor via distortion of the endoplasmic reticulum. unassigned - 1.3.98.3 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27622317&form=6&db=m Raised interferon ?, type 3 interferon and interferon stimulated genes - evidence of innate immune activation in neutrophilic asthma. ongoing research,unassigned 2,0 1.3.98.3 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15890971&form=6&db=m The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents. causal interaction,ongoing research,unassigned 4,2,0 1.3.98.3 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20420911&form=6&db=m Differential regulation of Sciaenops ocellatus viperin expression by intracellular and extracellular bacterial pathogens. causal interaction,unassigned 3,0 1.3.98.3 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25254077&form=6&db=m Viperin: a radical response to viral infection. causal interaction,therapeutic application,unassigned 4,4,0 1.3.98.3 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31666594&form=6&db=m The interferon stimulated gene viperin, restricts Shigella. flexneri in vitro. causal interaction,therapeutic application,unassigned 4,3,0 1.3.98.3 Bluetongue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32784101&form=6&db=m Ovine viperin inhibits bluetongue virus replication. causal interaction,therapeutic application,unassigned 4,2,0 1.3.98.3 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29080685&form=6&db=m Functional characterization of interferon regulatory factor 5 and its role in the innate antiviral immune response. unassigned - 1.3.98.3 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21880757&form=6&db=m The interferon-inducible gene viperin restricts West Nile virus pathogenesis. causal interaction,unassigned 4,0 1.3.98.3 Central Nervous System Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29544502&form=6&db=m Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 1.3.98.3 Classical Swine Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29061156&form=6&db=m Porcine Viperin protein inhibits the replication of classical swine fever virus (CSFV) in vitro. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 1.3.98.3 Classical Swine Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31517388&form=6&db=m Viperin Inhibits Classical Swine Fever Virus Replication by Interacting with Viral Non-structural 5A Protein. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 1.3.98.3 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32653585&form=6&db=m Impact of Aeromonas hydrophila and infectious spleen and kidney necrosis virus infections on susceptibility and host immune response in Chinese perch (Siniperca chuatsi). unassigned - 1.3.98.3 coproporphyrinogen dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30181920&form=6&db=m Viperin Deficiency Promotes Polarization of Macrophages and Secretion of M1 and M2 Cytokines. causal interaction,unassigned 4,0 1.3.98.3 Cytomegalovirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15890971&form=6&db=m The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents. causal interaction,ongoing research,unassigned 4,2,0 1.3.98.3 Cytomegalovirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21664572&form=6&db=m Viperin turns coat in cytomegalovirus infection. causal interaction,therapeutic application,unassigned 2,1,0 1.3.98.3 Cytomegalovirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23935494&form=6&db=m Viperin regulates cellular lipid metabolism during human cytomegalovirus infection. ongoing research,therapeutic application,unassigned 4,1,0 1.3.98.3 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29300094&form=6&db=m 1,2-Diol Dehydration by the Radical SAM Enzyme AprD4: A Matter of Proton Circulation and Substrate Flexibility. therapeutic application,unassigned 1,0 1.3.98.3 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30872404&form=6&db=m Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis. unassigned - 1.3.98.3 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31951306&form=6&db=m Mechanism of Diol Dehydration by a Promiscuous Radical-SAM Enzyme Homologue of the Antiviral Enzyme Viperin (RSAD2). unassigned - 1.3.98.3 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23638199&form=6&db=m Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 1.3.98.3 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25766282&form=6&db=m Sequence analysis and characterisation of virally induced viperin in the saltwater crocodile (Crocodylus porosus). causal interaction,unassigned 1,0 1.3.98.3 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29925952&form=6&db=m A naturally occurring antiviral ribonucleotide encoded by the human genome. therapeutic application,unassigned 1,0 1.3.98.3 Dwarfism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30718282&form=6&db=m The anti-viral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion. unassigned - 1.3.98.3 Encephalitis, Japanese http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18768981&form=6&db=m The cellular antiviral protein viperin is attenuated by proteasome-mediated protein degradation in Japanese encephalitis virus-infected cells. causal interaction,therapeutic application,unassigned 3,1,0 1.3.98.3 Encephalitis, Japanese http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29321318&form=6&db=m Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation. causal interaction,therapeutic application,unassigned 2,3,0 1.3.98.3 Encephalitis, Tick-Borne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24245804&form=6&db=m Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 1.3.98.3 Encephalitis, Tick-Borne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29321318&form=6&db=m Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation. causal interaction,therapeutic application,unassigned 2,3,0 1.3.98.3 Equine Infectious Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25122784&form=6&db=m Equine viperin restricts equine infectious anemia virus replication by inhibiting the production and/or release of viral Gag, Env, and receptor via distortion of the endoplasmic reticulum. unassigned - 1.3.98.3 Flavivirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29544502&form=6&db=m Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 1.3.98.3 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29254175&form=6&db=m Targeting viperin improves diet-induced glucose intolerance but not adipose tissue inflammation. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 1.3.98.3 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27943419&form=6&db=m Involvement of viperin in prevention of intrauterine transmission of hepatitis B virus. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 1.3.98.3 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19920176&form=6&db=m The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic alpha-helix. therapeutic application,unassigned 1,0 1.3.98.3 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21142818&form=6&db=m The interferon inducible gene: Viperin. causal interaction,therapeutic application,unassigned 1,1,0 1.3.98.3 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21957124&form=6&db=m Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 1.3.98.3 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22045669&form=6&db=m The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A. causal interaction,therapeutic application,unassigned 3,2,0 1.3.98.3 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25254077&form=6&db=m Viperin: a radical response to viral infection. causal interaction,therapeutic application,unassigned 4,4,0 1.3.98.3 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29925952&form=6&db=m A naturally occurring antiviral ribonucleotide encoded by the human genome. therapeutic application,unassigned 1,0 1.3.98.3 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31977203&form=6&db=m Interactions between Viperin, Vesicle-Associated Membrane Protein A, and Hepatitis C Virus Protein NS5A Modulate Viperin Activity and NS5A Degradation. ongoing research,therapeutic application,unassigned 2,1,0 1.3.98.3 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16108059&form=6&db=m Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector. therapeutic application,unassigned 1,0 1.3.98.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25078699&form=6&db=m Herpes simplex virus 1 counteracts viperin via its virion host shutoff protein UL41. ongoing research,unassigned 2,0 1.3.98.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31921110&form=6&db=m The Interaction Mechanism Between Herpes Simplex Virus 1 Glycoprotein D and Host Antiviral Protein Viperin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,3,0 1.3.98.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34406117&form=6&db=m Viperin has species-specific roles in response to herpes simplex virus infection. causal interaction,ongoing research,unassigned 4,4,0 1.3.98.3 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32599823&form=6&db=m Host-Pathogen Responses to Pandemic Influenza H1N1pdm09 in a Human Respiratory Airway Model. unassigned - 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11752458&form=6&db=m Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. ongoing research,unassigned 2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16982913&form=6&db=m TLR3 Ligation Activates an Antiviral Response in Human Fetal Astrocytes: A Role for Viperin/cig5. causal interaction,therapeutic application,unassigned 2,2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17428947&form=6&db=m Transcriptional activation of interferon-stimulated genes but not of cytokine genes after primary infection of rhesus macaques with dengue virus type 1. therapeutic application,unassigned 1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18077728&form=6&db=m Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virus. causal interaction,therapeutic application,unassigned 3,4,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18658112&form=6&db=m Gene expression profiles during in vivo human rhinovirus infection: insights into the host response. diagnostic usage,ongoing research,unassigned 4,4,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20308629&form=6&db=m IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction. causal interaction,ongoing research,unassigned 3,2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20410488&form=6&db=m Viperin Is Highly Induced in Neutrophils and Macrophages during Acute and Chronic Lymphocytic Choriomeningitis Virus Infection. causal interaction,ongoing research,unassigned 4,4,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20420911&form=6&db=m Differential regulation of Sciaenops ocellatus viperin expression by intracellular and extracellular bacterial pathogens. causal interaction,unassigned 3,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21142818&form=6&db=m The interferon inducible gene: Viperin. causal interaction,therapeutic application,unassigned 1,1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21527675&form=6&db=m Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity. causal interaction,therapeutic application,unassigned 3,2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21664572&form=6&db=m Viperin turns coat in cytomegalovirus infection. causal interaction,therapeutic application,unassigned 2,1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21880757&form=6&db=m The interferon-inducible gene viperin restricts West Nile virus pathogenesis. causal interaction,unassigned 4,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22677126&form=6&db=m HIV-1 infection of human macrophages directly induces viperin which inhibits viral production. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22806943&form=6&db=m Identification of an intrahepatic transcriptional signature associated with self-limiting infection in the woodchuck model of hepatitis B. causal interaction,unassigned 3,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23160199&form=6&db=m Viperin restricts chikungunya virus replication and pathology. causal interaction,therapeutic application,unassigned 1,1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23638199&form=6&db=m Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23935494&form=6&db=m Viperin regulates cellular lipid metabolism during human cytomegalovirus infection. ongoing research,therapeutic application,unassigned 4,1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24525178&form=6&db=m Rock bream (Oplegnathus fasciatus) viperin is a virus-responsive protein that modulates innate immunity and promotes resistance against megalocytivirus infection. causal interaction,therapeutic application,unassigned 3,3,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25031336&form=6&db=m Histone Deacetylase 6 Inhibits Influenza A Virus Release by Downregulating the Trafficking of Viral Components to the Plasma Membrane via Its Substrate, Acetylated Microtubules. ongoing research,therapeutic application,unassigned 2,2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25058853&form=6&db=m Fish viperin exerts a conserved antiviral function through RLR-triggered IFN signaling pathway. ongoing research,therapeutic application,unassigned 1,1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25078699&form=6&db=m Herpes simplex virus 1 counteracts viperin via its virion host shutoff protein UL41. ongoing research,unassigned 2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25433308&form=6&db=m Viperin protein expression inhibits the late stage of respiratory syncytial virus morphogenesis. ongoing research,unassigned 4,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25814471&form=6&db=m Viperin is induced following toll-like receptor 3 (TLR3) ligation and has a virus-responsive function in human trophoblast cells. diagnostic usage,ongoing research,unassigned 3,2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26790943&form=6&db=m The neuropathogenic T953 strain of equine herpesvirus-1 inhibits type-I IFN mediated antiviral activity in equine endothelial cells. unassigned - 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27232627&form=6&db=m Monkey Viperin Restricts Porcine Reproductive and Respiratory Syndrome Virus Replication. therapeutic application,unassigned 2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27456665&form=6&db=m Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4. ongoing research,therapeutic application,unassigned 3,2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27943419&form=6&db=m Involvement of viperin in prevention of intrauterine transmission of hepatitis B virus. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28095439&form=6&db=m Intracranial Injection of Dengue Virus Induces Interferon Stimulated Genes and CD8+ T Cell Infiltration by Sphingosine Kinase 1 Independent Pathways. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28708394&form=6&db=m Human Viperin Causes Radical SAM-Dependent Elongation of Escherichia coli, Hinting at Its Physiological Role. causal interaction,therapeutic application,unassigned 3,1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28968760&form=6&db=m Detection of Host Response to Viral Respiratory Infection by Measurement of Messenger RNA for MxA, TRIM21, and Viperin in Nasal Swabs. causal interaction,diagnostic usage,unassigned 1,3,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29061156&form=6&db=m Porcine Viperin protein inhibits the replication of classical swine fever virus (CSFV) in vitro. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29341929&form=6&db=m The infection of red seabream iridovirus in mandarin fish (Siniperca chuatsi) and the host immune related gene expression profiles. diagnostic usage,ongoing research,unassigned 1,2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29544502&form=6&db=m Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30036788&form=6&db=m Toll-like receptor agonist R848 blocks Zika virus replication by inducing the antiviral protein viperin. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30540955&form=6&db=m The antiviral mechanism of viperin and its splice variant in spring viremia of carp virus infected fathead minnow cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30587778&form=6&db=m Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30665948&form=6&db=m Viperin controls chikungunya virus-specific pathogenic T cell IFN? Th1 stimulation in mice. causal interaction,ongoing research,unassigned 4,2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30869582&form=6&db=m In vitro and in vivo roles of sphingosine kinase 2 during dengue virus infection. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31299975&form=6&db=m Rhinovirus replication and innate immunity in highly differentiated human airway epithelial cells. causal interaction,unassigned 2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31468087&form=6&db=m Chichen type III interferon produced by silkworm bioreactor induces ISG expression and restricts ALV-J infection in vitro. ongoing research,unassigned 1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31517388&form=6&db=m Viperin Inhibits Classical Swine Fever Virus Replication by Interacting with Viral Non-structural 5A Protein. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31720044&form=6&db=m Viperin Differentially Induces Interferon-Stimulated Genes in Distinct Cell Types. causal interaction,therapeutic application,unassigned 1,2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31774391&form=6&db=m Dengue virus infects the mouse eye following systemic or intracranial infection and induces inflammatory responses. causal interaction,unassigned 1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32784101&form=6&db=m Ovine viperin inhibits bluetongue virus replication. causal interaction,therapeutic application,unassigned 4,2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32800881&form=6&db=m Viperin protein inhibits the replication of caprine parainfluenza virus 3 (CPIV 3) by interaction with viral N protein. therapeutic application,unassigned 2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32867971&form=6&db=m Differential immunomodulatory effect of vitamin D (1,25 (OH)2 D3) on the innate immune response in different types of cells infected in vitro with infectious bursal disease virus. diagnostic usage,therapeutic application,unassigned 1,1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32937646&form=6&db=m Prokaryotic viperins produce diverse antiviral molecules. therapeutic application,unassigned 2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32983049&form=6&db=m Transcriptomic Analysis and Functional Characterization Reveal the Duck Interferon Regulatory Factor 1 as an Important Restriction Factor in the Replication of Tembusu Virus. therapeutic application,unassigned 1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33411856&form=6&db=m TRK-Fused Gene (TFG), a protein involved in protein secretion pathways, is an essential component of the antiviral innate immune response. ongoing research,unassigned 2,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33614762&form=6&db=m Dynamic Changes in the Expression of Interferon-Stimulated Genes in Joints of SPF Chickens Infected With Avian Reovirus. therapeutic application,unassigned 1,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34116117&form=6&db=m Viperin_sv1 promotes RIG-I expression and suppresses SVCV replication through its radical SAM domain. causal interaction,unassigned 3,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34372530&form=6&db=m Viperin, an IFN-Stimulated Protein, Delays Rotavirus Release by Inhibiting Non-Structural Protein 4 (NSP4)-Induced Intrinsic Apoptosis. ongoing research,unassigned 4,0 1.3.98.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34406117&form=6&db=m Viperin has species-specific roles in response to herpes simplex virus infection. causal interaction,ongoing research,unassigned 4,4,0 1.3.98.3 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18005719&form=6&db=m Influenza virus not cRAFTy enough to dodge viperin. ongoing research,therapeutic application,unassigned 2,1,0 1.3.98.3 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18005724&form=6&db=m The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 1.3.98.3 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21142818&form=6&db=m The interferon inducible gene: Viperin. causal interaction,therapeutic application,unassigned 1,1,0 1.3.98.3 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22377585&form=6&db=m In vivo and in vitro studies on the antiviral activities of viperin against influenza H1N1 virus infection. causal interaction,ongoing research,unassigned 1,4,0 1.3.98.3 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24154548&form=6&db=m Investigating the efficacy of pamidronate, a chemical inhibitor of farnesyl pyrophosphate synthase, in the inhibition of influenza virus infection in vitro and in vivo. ongoing research,therapeutic application,unassigned 3,4,0 1.3.98.3 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25031336&form=6&db=m Histone Deacetylase 6 Inhibits Influenza A Virus Release by Downregulating the Trafficking of Viral Components to the Plasma Membrane via Its Substrate, Acetylated Microtubules. ongoing research,therapeutic application,unassigned 2,2,0 1.3.98.3 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27988795&form=6&db=m A novel anti-viral role for STAT3 in IFN-? signalling responses. unassigned - 1.3.98.3 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29925952&form=6&db=m A naturally occurring antiviral ribonucleotide encoded by the human genome. therapeutic application,unassigned 1,0 1.3.98.3 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30003769&form=6&db=m [Advances in Avian Antiviral Innate Immune Effectors]. unassigned - 1.3.98.3 Lymphocytic Choriomeningitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20410488&form=6&db=m Viperin Is Highly Induced in Neutrophils and Macrophages during Acute and Chronic Lymphocytic Choriomeningitis Virus Infection. causal interaction,ongoing research,unassigned 4,4,0 1.3.98.3 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31341090&form=6&db=m Intrinsic expression of viperin regulates thermogenesis in adipose tissues. causal interaction,unassigned 3,0 1.3.98.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30872404&form=6&db=m Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis. unassigned - 1.3.98.3 Newcastle Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20308629&form=6&db=m IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction. causal interaction,ongoing research,unassigned 3,2,0 1.3.98.3 Newcastle Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26049096&form=6&db=m Molecular characterization and expression analysis of the duck viperin gene. diagnostic usage,unassigned 3,0 1.3.98.3 Newcastle Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29061156&form=6&db=m Porcine Viperin protein inhibits the replication of classical swine fever virus (CSFV) in vitro. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 1.3.98.3 Newcastle Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31003187&form=6&db=m Chicken viperin inhibits Newcastle disease virus infection in vitro: A possible interaction with the viral matrix protein. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 1.3.98.3 Paramyxoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32800881&form=6&db=m Viperin protein inhibits the replication of caprine parainfluenza virus 3 (CPIV 3) by interaction with viral N protein. therapeutic application,unassigned 2,0 1.3.98.3 Porcine Reproductive and Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27232627&form=6&db=m Monkey Viperin Restricts Porcine Reproductive and Respiratory Syndrome Virus Replication. therapeutic application,unassigned 2,0 1.3.98.3 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27418822&form=6&db=m Reduced sputum expression of interferon-stimulated genes in severe COPD. causal interaction,diagnostic usage,unassigned 1,3,0 1.3.98.3 Rabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27456665&form=6&db=m Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4. ongoing research,therapeutic application,unassigned 3,2,0 1.3.98.3 Rabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29925952&form=6&db=m A naturally occurring antiviral ribonucleotide encoded by the human genome. therapeutic application,unassigned 1,0 1.3.98.3 Respiratory Tract Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28968760&form=6&db=m Detection of Host Response to Viral Respiratory Infection by Measurement of Messenger RNA for MxA, TRIM21, and Viperin in Nasal Swabs. causal interaction,diagnostic usage,unassigned 1,3,0 1.3.98.3 ring-type e3 ubiquitin transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31812350&form=6&db=m Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense. causal interaction,unassigned 4,0 1.3.98.3 Rotavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34372530&form=6&db=m Viperin, an IFN-Stimulated Protein, Delays Rotavirus Release by Inhibiting Non-Structural Protein 4 (NSP4)-Induced Intrinsic Apoptosis. ongoing research,unassigned 4,0 1.3.98.3 Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31769977&form=6&db=m Electron Paramagnetic Resonance Spectroscopic Identification of the Fe-S Clusters in the SPASM Domain-Containing Radical SAM Enzyme PqqE. unassigned - 1.3.98.3 ST Elevation Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25007837&form=6&db=m Identification of a circulating microvesicle protein network involved in ST-elevation myocardial infarction. unassigned - 1.3.98.3 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20308629&form=6&db=m IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction. causal interaction,ongoing research,unassigned 3,2,0 1.3.98.3 Viremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30540955&form=6&db=m The antiviral mechanism of viperin and its splice variant in spring viremia of carp virus infected fathead minnow cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18768981&form=6&db=m The cellular antiviral protein viperin is attenuated by proteasome-mediated protein degradation in Japanese encephalitis virus-infected cells. causal interaction,therapeutic application,unassigned 3,1,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20308629&form=6&db=m IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction. causal interaction,ongoing research,unassigned 3,2,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20410488&form=6&db=m Viperin Is Highly Induced in Neutrophils and Macrophages during Acute and Chronic Lymphocytic Choriomeningitis Virus Infection. causal interaction,ongoing research,unassigned 4,4,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21880757&form=6&db=m The interferon-inducible gene viperin restricts West Nile virus pathogenesis. causal interaction,unassigned 4,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22377585&form=6&db=m In vivo and in vitro studies on the antiviral activities of viperin against influenza H1N1 virus infection. causal interaction,ongoing research,unassigned 1,4,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23237906&form=6&db=m Characterization of tilapia (Oreochromis niloticus) viperin expression, and inhibition of bacterial growth and modulation of immune-related gene expression by electrotransfer of viperin DNA into zebrafish muscle. causal interaction,unassigned 2,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23638199&form=6&db=m Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24154548&form=6&db=m Investigating the efficacy of pamidronate, a chemical inhibitor of farnesyl pyrophosphate synthase, in the inhibition of influenza virus infection in vitro and in vivo. ongoing research,therapeutic application,unassigned 3,4,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24157441&form=6&db=m The role of viperin in the innate antiviral response. causal interaction,unassigned 4,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24525178&form=6&db=m Rock bream (Oplegnathus fasciatus) viperin is a virus-responsive protein that modulates innate immunity and promotes resistance against megalocytivirus infection. causal interaction,therapeutic application,unassigned 3,3,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25254077&form=6&db=m Viperin: a radical response to viral infection. causal interaction,therapeutic application,unassigned 4,4,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25311379&form=6&db=m Characterisation of chicken viperin. therapeutic application,unassigned 2,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25433308&form=6&db=m Viperin protein expression inhibits the late stage of respiratory syncytial virus morphogenesis. ongoing research,unassigned 4,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25766282&form=6&db=m Sequence analysis and characterisation of virally induced viperin in the saltwater crocodile (Crocodylus porosus). causal interaction,unassigned 1,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26190498&form=6&db=m Identification and functional characterization of viperin of amphioxus Branchiostoma japonicum: Implications for ancient origin of viperin-mediated antiviral response. causal interaction,therapeutic application,unassigned 1,2,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26275803&form=6&db=m Equine herpesvirus-1 suppresses type-I interferon induction in equine endothelial cells. diagnostic usage,unassigned 1,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27232627&form=6&db=m Monkey Viperin Restricts Porcine Reproductive and Respiratory Syndrome Virus Replication. therapeutic application,unassigned 2,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27834682&form=6&db=m Does Viperin Function as a Radical S-Adenosyl-l-methionine-dependent Enzyme in Regulating Farnesylpyrophosphate Synthase Expression and Activity? causal interaction,unassigned 3,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28968760&form=6&db=m Detection of Host Response to Viral Respiratory Infection by Measurement of Messenger RNA for MxA, TRIM21, and Viperin in Nasal Swabs. causal interaction,diagnostic usage,unassigned 1,3,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29202415&form=6&db=m The interplay between viperin antiviral activity, lipid droplets and Junín mammarenavirus multiplication. causal interaction,therapeutic application,unassigned 3,3,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29213275&form=6&db=m Dynamic Changes in Host Gene Expression following unassigned - 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29254175&form=6&db=m Targeting viperin improves diet-induced glucose intolerance but not adipose tissue inflammation. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29321318&form=6&db=m Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation. causal interaction,therapeutic application,unassigned 2,3,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30059238&form=6&db=m The Role of Viperin in Antiflavivirus Responses. causal interaction,therapeutic application,unassigned 3,2,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30584907&form=6&db=m Grouper viperin acts as a crucial antiviral molecule against iridovirus. ongoing research,unassigned 2,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31003187&form=6&db=m Chicken viperin inhibits Newcastle disease virus infection in vitro: A possible interaction with the viral matrix protein. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32061099&form=6&db=m Viperin, through its radical-SAM activity, depletes cellular nucleotide pools and interferes with mitochondrial metabolism to inhibit viral replication. unassigned - 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32546482&form=6&db=m Viperin: An ancient radical SAM enzyme finds its place in modern cellular metabolism and innate immunity. causal interaction,unassigned 3,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32603630&form=6&db=m Viperin Reveals Its True Function. unassigned - 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32655518&form=6&db=m Inhibition of African Swine Fever Virus Replication by Porcine Type I and Type II Interferons. causal interaction,therapeutic application,unassigned 1,1,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34108265&form=6&db=m Viperin interacts with PEX19 to mediate peroxisomal augmentation of the innate antiviral response. causal interaction,therapeutic application,unassigned 4,2,0 1.3.98.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34406117&form=6&db=m Viperin has species-specific roles in response to herpes simplex virus infection. causal interaction,ongoing research,unassigned 4,4,0 1.3.98.3 Yellow Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29321318&form=6&db=m Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation. causal interaction,therapeutic application,unassigned 2,3,0 1.3.98.3 Zika Virus Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28667332&form=6&db=m Viperin is an important host restriction factor in control of Zika virus infection. unassigned - 1.3.98.3 Zika Virus Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30036788&form=6&db=m Toll-like receptor agonist R848 blocks Zika virus replication by inducing the antiviral protein viperin. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 1.3.98.3 Zika Virus Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33305387&form=6&db=m Zika virus infection of first trimester trophoblast cells affects cell migration, metabolism and immune homeostasis control. diagnostic usage,unassigned 3,0