1.3.1.70 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26540160&form=6&db=m The Tm7sf2 Gene Deficiency Protects Mice against Endotoxin-Induced Acute Kidney Injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.3.1.70 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21420716&form=6&db=m Differential gene expression profiling of aggressive and nonaggressive follicular carcinomas. diagnostic usage,unassigned 3,0 1.3.1.70 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19526546&form=6&db=m Quantitation of glycogen synthase kinase-3 sensitive proteins in neuronal membrane rafts. causal interaction,unassigned 4,0 1.3.1.70 Bone Diseases, Developmental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32304187&form=6&db=m A new case of Greenberg dysplasia and literature review suggest that Greenberg dysplasia, dappled diaphyseal dysplasia, and Astley-Kendall dysplasia are allelic disorders. causal interaction,unassigned 2,0 1.3.1.70 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24293108&form=6&db=m The clinicopathological significance of lamin A/C, lamin B1 and lamin B receptor mRNA expression in human breast cancer. diagnostic usage,ongoing research,unassigned 3,3,0 1.3.1.70 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32316379&form=6&db=m Spatiotemporal Mislocalization of Nuclear Membrane-Associated Proteins in ?-Irradiation-Induced Senescent Cells. ongoing research,unassigned 1,0 1.3.1.70 Candidiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26231054&form=6&db=m ERG2 and ERG24 Are Required for Normal Vacuolar Physiology as Well as Candida albicans Pathogenicity in a Murine Model of Disseminated but Not Vaginal Candidiasis. causal interaction,therapeutic application,unassigned 3,4,0 1.3.1.70 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21420716&form=6&db=m Differential gene expression profiling of aggressive and nonaggressive follicular carcinomas. diagnostic usage,unassigned 3,0 1.3.1.70 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30982228&form=6&db=m Distinct cellular responses to replication stress leading to apoptosis or senescence. ongoing research,therapeutic application,unassigned 4,1,0 1.3.1.70 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32316379&form=6&db=m Spatiotemporal Mislocalization of Nuclear Membrane-Associated Proteins in ?-Irradiation-Induced Senescent Cells. ongoing research,unassigned 1,0 1.3.1.70 Chondrodysplasia Punctata http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11592808&form=6&db=m Genetic disorders of cholesterol biosynthesis in mice and humans. unassigned - 1.3.1.70 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30155352&form=6&db=m Comprehensive analysis of metastasis-related genes reveals a gene signature predicting the survival of colon cancer patients. diagnostic usage,ongoing research,unassigned 4,1,0 1.3.1.70 delta14-sterol reductase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12618959&form=6&db=m Autosomal recessive HEM/Greenberg skeletal dysplasia is caused by 3 beta-hydroxysterol delta 14-reductase deficiency due to mutations in the lamin B receptor gene. causal interaction,unassigned 4,0 1.3.1.70 delta14-sterol reductase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17403717&form=6&db=m HEM dysplasia and ichthyosis are likely laminopathies and not due to 3beta-hydroxysterol Delta14-reductase deficiency. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 1.3.1.70 delta14-sterol reductase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27341299&form=6&db=m Impaired cell proliferation in regenerating liver of 3 ?-hydroxysterol ?14-reductase (TM7SF2) knock-out mice. causal interaction,unassigned 3,0 1.3.1.70 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11507226&form=6&db=m Fate of the inner nuclear membrane protein lamin B receptor and nuclear lamins in herpes simplex virus type 1 infection. unassigned - 1.3.1.70 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11866460&form=6&db=m A three-residue signal confers localization of a reporter protein in the inner nuclear membrane. ongoing research,unassigned 2,0 1.3.1.70 Ichthyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12490533&form=6&db=m Mutations at the mouse ichthyosis locus are within the lamin B receptor gene: a single gene model for human Pelger-Huët anomaly. unassigned - 1.3.1.70 Ichthyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17403717&form=6&db=m HEM dysplasia and ichthyosis are likely laminopathies and not due to 3beta-hydroxysterol Delta14-reductase deficiency. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 1.3.1.70 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11507226&form=6&db=m Fate of the inner nuclear membrane protein lamin B receptor and nuclear lamins in herpes simplex virus type 1 infection. unassigned - 1.3.1.70 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32246222&form=6&db=m Characterization of lamin B receptor of Sf9 cells and its fate during Autographa californica nucleopolyhedrovirus infection. ongoing research,unassigned 3,0 1.3.1.70 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33121932&form=6&db=m Tm7sf2 gene promotes adipocyte differentiation of mouse embryonic fibroblasts and improves insulin sensitivity. ongoing research,unassigned 2,0 1.3.1.70 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33330474&form=6&db=m Tm7sf2 Disruption Alters Radial Gene Positioning in Mouse Liver Leading to Metabolic Defects and Diabetes Characteristics. causal interaction,unassigned 2,0 1.3.1.70 Laminopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17403717&form=6&db=m HEM dysplasia and ichthyosis are likely laminopathies and not due to 3beta-hydroxysterol Delta14-reductase deficiency. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 1.3.1.70 Laminopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19645629&form=6&db=m LMNA, ZMPSTE24, and LBR are not mutated in scleroderma. causal interaction,unassigned 1,0 1.3.1.70 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22133120&form=6&db=m Antinuclear antibodies as ancillary markers in primary biliary cirrhosis. causal interaction,unassigned 3,0 1.3.1.70 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23495774&form=6&db=m Molecular diagnostics of primary biliary cirrhosis. causal interaction,unassigned 1,0 1.3.1.70 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2167346&form=6&db=m Identification and characterization of autoantibodies against the nuclear envelope lamin B receptor from patients with primary biliary cirrhosis. ongoing research,unassigned 4,0 1.3.1.70 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8550049&form=6&db=m Autoantibodies from patients with primary biliary cirrhosis recognize a region within the nucleoplasmic domain of inner nuclear membrane protein LBR. ongoing research,unassigned 2,0 1.3.1.70 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33997099&form=6&db=m Discovery of key genes as novel biomarkers specifically associated with HPV-negative cervical cancer. unassigned - 1.3.1.70 Metabolism, Inborn Errors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11592808&form=6&db=m Genetic disorders of cholesterol biosynthesis in mice and humans. unassigned - 1.3.1.70 Mevalonate Kinase Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11592808&form=6&db=m Genetic disorders of cholesterol biosynthesis in mice and humans. unassigned - 1.3.1.70 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18324346&form=6&db=m Candidate diagnostic markers and tumor suppressor genes for adrenocortical carcinoma by expression profile of genes on chromosome 11q13. diagnostic usage,unassigned 1,0 1.3.1.70 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21420716&form=6&db=m Differential gene expression profiling of aggressive and nonaggressive follicular carcinomas. diagnostic usage,unassigned 3,0 1.3.1.70 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27760841&form=6&db=m Loss of lamin B receptor is necessary to induce cellular senescence. ongoing research,unassigned 4,0 1.3.1.70 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32316379&form=6&db=m Spatiotemporal Mislocalization of Nuclear Membrane-Associated Proteins in ?-Irradiation-Induced Senescent Cells. ongoing research,unassigned 1,0 1.3.1.70 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25804527&form=6&db=m The loss of Tm7sf gene accelerates skin papilloma formation in mice. causal interaction,unassigned 3,0 1.3.1.70 Pelger-Huet Anomaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12490533&form=6&db=m Mutations at the mouse ichthyosis locus are within the lamin B receptor gene: a single gene model for human Pelger-Huët anomaly. unassigned - 1.3.1.70 Pelger-Huet Anomaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18550262&form=6&db=m Mouse neutrophils lacking lamin B-receptor expression exhibit aberrant development and lack critical functional responses. causal interaction,unassigned 1,0 1.3.1.70 Pelger-Huet Anomaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27483354&form=6&db=m Alterations in nuclear structure promote lupus autoimmunity in a mouse model. ongoing research,therapeutic application,unassigned 2,1,0 1.3.1.70 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26540160&form=6&db=m The Tm7sf2 Gene Deficiency Protects Mice against Endotoxin-Induced Acute Kidney Injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.3.1.70 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19645629&form=6&db=m LMNA, ZMPSTE24, and LBR are not mutated in scleroderma. causal interaction,unassigned 1,0 1.3.1.70 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33997099&form=6&db=m Discovery of key genes as novel biomarkers specifically associated with HPV-negative cervical cancer. unassigned -