1.2.4.2 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1640293&form=6&db=m Alpha-ketoglutarate dehydrogenase deficiency presenting as congenital lactic acidosis. causal interaction,unassigned 4,0 1.2.4.2 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1770913&form=6&db=m Adaptation of renal tricarboxylic acid cycle metabolism to various acid-base states: study with [3-13C,5-15N]glutamine. causal interaction,therapeutic application,unassigned 4,1,0 1.2.4.2 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2283987&form=6&db=m Biochemical pathways and modulators of renal ammoniagenesis. causal interaction,unassigned 4,0 1.2.4.2 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2283989&form=6&db=m Intramitochondrial pH and ammonium production in rat and dog kidney cortex. causal interaction,therapeutic application,unassigned 4,2,0 1.2.4.2 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2563203&form=6&db=m Ammoniagenesis by cultured human renal cortical epithelial cells: study with 15N. causal interaction,unassigned 4,0 1.2.4.2 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2801699&form=6&db=m Regulation of rat kidney mitochondrial metabolism in acute acidosis. causal interaction,therapeutic application,unassigned 1,1,0 1.2.4.2 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7470078&form=6&db=m Activation of oxoglutarate dehydrogenase in the kidney in response to acute acidosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 1.2.4.2 Acidosis, Lactic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=184426&form=6&db=m Lactic acidosis in three sibs due to defects in both pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes. causal interaction,unassigned 2,0 1.2.4.2 Acidosis, Lactic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=413089&form=6&db=m Deficiency of dihydrolipoyl dehydrogenase (a component of the pyruvate and alpha-ketoglutarate dehydrogenase complexes): a cause of congenital chronic lactic acidosis in infancy. causal interaction,unassigned 4,0 1.2.4.2 Acidosis, Lactic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1640293&form=6&db=m Alpha-ketoglutarate dehydrogenase deficiency presenting as congenital lactic acidosis. causal interaction,unassigned 4,0 1.2.4.2 Acidosis, Lactic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6897145&form=6&db=m Congenital lactic acidosis, alpha-ketoglutaric aciduria and variant form of maple syrup urine disease due to a single enzyme defect: dihydrolipoyl dehydrogenase deficiency. causal interaction,unassigned 4,0 1.2.4.2 Acidosis, Lactic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8815392&form=6&db=m Alterations of thiamine phosphorylation and of thiamine-dependent enzymes in Alzheimer's disease. causal interaction,unassigned 4,0 1.2.4.2 Acidosis, Lactic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24256811&form=6&db=m Mutations in the lipoyltransferase LIPT1 gene cause a fatal disease associated with a specific lipoylation defect of the 2-ketoacid dehydrogenase complexes. causal interaction,unassigned 4,0 1.2.4.2 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30967137&form=6&db=m The CIMP-high phenotype is associated with energy metabolism alterations in colon adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 1.2.4.2 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32466567&form=6&db=m Activation of Mitochondrial 2-Oxoglutarate Dehydrogenase by Cocarboxylase in Human Lung Adenocarcinoma Cells A549 Is p53/p21-Dependent and Impairs Cellular Redox State, Mimicking the Cisplatin Action. causal interaction,unassigned 1,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2087217&form=6&db=m Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease. diagnostic usage,ongoing research,unassigned 1,2,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7974008&form=6&db=m Pseudogene of dihydrolipoyl succinyltransferase (E2k) found by PCR amplification and direct sequencing of rodent-human cell hybrid DNAs. causal interaction,unassigned 2,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8122883&form=6&db=m Abnormality of the alpha-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8245957&form=6&db=m Brain alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8619544&form=6&db=m Brain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8940624&form=6&db=m Normal glutamate metabolism in Alzheimer's disease fibroblasts deficient in alpha-ketoglutarate dehydrogenase complex activity. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9329693&form=6&db=m Brain energy metabolizing enzymes in Alzheimer's disease: alpha-ketoglutarate dehydrogenase complex and cytochrome oxidase. unassigned - 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9778267&form=6&db=m Alpha-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation. causal interaction,unassigned 3,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9894876&form=6&db=m Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population. causal interaction,unassigned 4,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10610692&form=6&db=m Quantitative alpha-ketoglutarate dehydrogenase activity staining in brain sections and in cultured cells. causal interaction,diagnostic usage,unassigned 3,1,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10672231&form=6&db=m Oxidative stress and a key metabolic enzyme in Alzheimer brains, cultured cells, and an animal model of chronic oxidative deficits. causal interaction,therapeutic application,unassigned 4,3,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10676873&form=6&db=m The alpha-ketoglutarate dehydrogenase complex in neurodegeneration. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10976635&form=6&db=m Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype. causal interaction,diagnostic usage,unassigned 2,3,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11796747&form=6&db=m Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. causal interaction,unassigned 3,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11945122&form=6&db=m Structural basis of the dysfunctioning of human 2-oxo acid dehydrogenase complexes. causal interaction,unassigned 4,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11959459&form=6&db=m Oxidative stress increases internal calcium stores and reduces a key mitochondrial enzyme. causal interaction,unassigned 1,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12091195&form=6&db=m Implications for altered glutamate and GABA metabolism in the dorsolateral prefrontal cortex of aged schizophrenic patients. diagnostic usage,ongoing research,unassigned 3,3,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12111441&form=6&db=m Cerebrospinal fluid levels of thiamine in patients with Alzheimer's disease. causal interaction,unassigned 3,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15009635&form=6&db=m Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity. causal interaction,unassigned 4,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15377868&form=6&db=m Mitochondrial enzymes and endoplasmic reticulum calcium stores as targets of oxidative stress in neurodegenerative diseases. causal interaction,unassigned 4,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15389771&form=6&db=m Association of the dihydrolipoamide dehydrogenase gene with Alzheimer's disease in an Ashkenazi Jewish population. causal interaction,unassigned 4,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15663478&form=6&db=m Inhibition of the alpha-ketoglutarate dehydrogenase complex by the myeloperoxidase products, hypochlorous acid and mono-N-chloramine. causal interaction,therapeutic application,unassigned 4,2,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18206986&form=6&db=m Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease. causal interaction,unassigned 4,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19715758&form=6&db=m Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. causal interaction,therapeutic application,unassigned 3,4,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22820180&form=6&db=m An update on the role of mitochondrial ?-ketoglutarate dehydrogenase in oxidative stress. causal interaction,unassigned 3,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23604331&form=6&db=m Inhibition of ?-ketoglutarate-and pyruvate dehydrogenase complexes in E. coli by a glutathione S-transferase containing a pathological length poly-Q domain: A possible role of energy deficit in neurological diseases associated with poly-Q expansions? causal interaction,unassigned 4,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29860433&form=6&db=m Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy. causal interaction,diagnostic usage,unassigned 1,1,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30208076&form=6&db=m Computational prediction of changes in brain metabolic fluxes during Parkinson's disease from mRNA expression. unassigned - 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30847859&form=6&db=m Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Both Generate Superoxide/H2O2 in a Side Reaction and Each Could Contribute to Oxidative Stress in Mitochondria. causal interaction,unassigned 4,0 1.2.4.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33917565&form=6&db=m The Role of the Rare Variants in the Genes Encoding the Alpha-Ketoglutarate Dehydrogenase in Alzheimer's Disease. causal interaction,ongoing research,unassigned 1,1,0 1.2.4.2 Anemia, Megaloblastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4045602&form=6&db=m Diabetes mellitus, thiamine-dependent megaloblastic anemia, and sensorineural deafness associated with deficient alpha-ketoglutarate dehydrogenase activity. causal interaction,diagnostic usage,unassigned 2,1,0 1.2.4.2 Anemia, Sideroblastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4045602&form=6&db=m Diabetes mellitus, thiamine-dependent megaloblastic anemia, and sensorineural deafness associated with deficient alpha-ketoglutarate dehydrogenase activity. causal interaction,diagnostic usage,unassigned 2,1,0 1.2.4.2 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2675860&form=6&db=m Effects of thiamine deficiency on brain metabolism: implications for the pathogenesis of the Wernicke-Korsakoff syndrome. causal interaction,unassigned 4,0 1.2.4.2 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3724963&form=6&db=m Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy. 2. alpha-Ketoglutarate dehydrogenase. causal interaction,therapeutic application,unassigned 4,1,0 1.2.4.2 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8619544&form=6&db=m Brain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 1.2.4.2 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10672230&form=6&db=m The alpha-ketoglutarate dehydrogenase complex. causal interaction,diagnostic usage,unassigned 4,2,0 1.2.4.2 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10956063&form=6&db=m Oxidative metabolites of 5-S-cysteinylnorepinephrine are irreversible inhibitors of mitochondrial complex I and the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes: possible implications for neurodegenerative brain disorders. therapeutic application,unassigned 2,0 1.2.4.2 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29777685&form=6&db=m Thiamine preserves mitochondrial function in a rat model of traumatic brain injury, preventing inactivation of the 2-oxoglutarate dehydrogenase complex. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 1.2.4.2 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24927296&form=6&db=m Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0 1.2.4.2 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25184115&form=6&db=m Sources of superoxide/H2O2 during mitochondrial proline oxidation. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 1.2.4.2 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25270118&form=6&db=m Identification of a metabolic and canonical biomarker signature in Mexican HR+/HER2-, triple positive and triple-negative breast cancer patients. diagnostic usage,therapeutic application,unassigned 4,3,0 1.2.4.2 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31837001&form=6&db=m Discovery of rare coding variants in OGDHL and BRCA2 in relation to breast cancer risk in Chinese women. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 1.2.4.2 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23152800&form=6&db=m OGDHL is a modifier of AKT-dependent signaling and NF-?B function. causal interaction,unassigned 3,0 1.2.4.2 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27923773&form=6&db=m Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1? Stability in Aerobic Conditions. causal interaction,unassigned 3,0 1.2.4.2 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31175094&form=6&db=m A Novel Oxoglutarate Dehydrogenase-Like Mediated miR-214/TWIST1 Negative Feedback Loop Inhibits Pancreatic Cancer Growth and Metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.2.4.2 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31175094&form=6&db=m A Novel Oxoglutarate Dehydrogenase-Like Mediated miR-214/TWIST1 Negative Feedback Loop Inhibits Pancreatic Cancer Growth and Metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.2.4.2 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3207422&form=6&db=m Calcium sensitive isocitrate and 2-oxoglutarate dehydrogenase activities in rat liver and AS-30D hepatoma mitochondria. ongoing research,unassigned 3,0 1.2.4.2 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11746207&form=6&db=m Chemopreventive efficacy of selenium against N-nitrosodiethylamine-induced hepatoma in albino rats. unassigned - 1.2.4.2 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26073129&form=6&db=m Mitochondrial free fatty acid ?-oxidation supports oxidative phosphorylation and proliferation in cancer cells. diagnostic usage,unassigned 3,0 1.2.4.2 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31899205&form=6&db=m OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 1.2.4.2 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31146816&form=6&db=m Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway. diagnostic usage,ongoing research,unassigned 3,1,0 1.2.4.2 Charcot-Marie-Tooth Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23141294&form=6&db=m A nonsense mutation in DHTKD1 causes Charcot-Marie-Tooth disease type 2 in a large Chinese pedigree. unassigned - 1.2.4.2 Charcot-Marie-Tooth Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29661920&form=6&db=m DHTKD1 Deficiency Causes Charcot-Marie-Tooth Disease in Mice. causal interaction,unassigned 4,0 1.2.4.2 Charcot-Marie-Tooth Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30847859&form=6&db=m Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Both Generate Superoxide/H2O2 in a Side Reaction and Each Could Contribute to Oxidative Stress in Mitochondria. causal interaction,unassigned 4,0 1.2.4.2 Charcot-Marie-Tooth Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32633484&form=6&db=m Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex. unassigned - 1.2.4.2 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7210221&form=6&db=m [Activity of carbohydrate metabolism enzyme activity in normal and pathologic parodontal tissues] unassigned - 1.2.4.2 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30951392&form=6&db=m Emerging views of mitophagy in immunity and autoimmune diseases. unassigned - 1.2.4.2 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20136350&form=6&db=m Modulating effect of Withania somnifera on TCA cycle enzymes and electron transport chain in azoxymethane-induced colon cancer in mice. unassigned - 1.2.4.2 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30904169&form=6&db=m Aberrant hypermethylation of OGDHL gene promoter in sporadic colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 1.2.4.2 Coma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7899447&form=6&db=m [Intensity of glycolysis and activity of energy metabolism enzymes in rat brain after multiple exposures to hypoglycemic doses of insulin] ongoing research,unassigned 3,0 1.2.4.2 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1488803&form=6&db=m [The relation between oxidative processes and the glycogen content in the heart and liver of rabbits with chronic ischemic heart disease] causal interaction,therapeutic application,unassigned 1,2,0 1.2.4.2 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30951392&form=6&db=m Emerging views of mitophagy in immunity and autoimmune diseases. unassigned - 1.2.4.2 Deafness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4045602&form=6&db=m Diabetes mellitus, thiamine-dependent megaloblastic anemia, and sensorineural deafness associated with deficient alpha-ketoglutarate dehydrogenase activity. causal interaction,diagnostic usage,unassigned 2,1,0 1.2.4.2 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8815392&form=6&db=m Alterations of thiamine phosphorylation and of thiamine-dependent enzymes in Alzheimer's disease. causal interaction,unassigned 4,0 1.2.4.2 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10976635&form=6&db=m Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype. causal interaction,diagnostic usage,unassigned 2,3,0 1.2.4.2 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15456945&form=6&db=m Mitochondrial enzymes in schizophrenia. unassigned - 1.2.4.2 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4045602&form=6&db=m Diabetes mellitus, thiamine-dependent megaloblastic anemia, and sensorineural deafness associated with deficient alpha-ketoglutarate dehydrogenase activity. causal interaction,diagnostic usage,unassigned 2,1,0 1.2.4.2 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28387648&form=6&db=m Dysmorphic features, frontal cerebral cavernoma and hyperglycemia in a girl with a de novo deletion of 7.23 Mb in region 7p13-p12.1. causal interaction,unassigned 4,0 1.2.4.2 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34484123&form=6&db=m Knock-Out of DHTKD1 Alters Mitochondrial Respiration and Function, and May Represent a Novel Pathway in Cardiometabolic Disease Risk. unassigned - 1.2.4.2 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31704098&form=6&db=m Fumarate accumulation involved in renal diabetic fibrosis in Goto-Kakizaki rats. causal interaction,unassigned 4,0 1.2.4.2 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12495372&form=6&db=m Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity. therapeutic application,unassigned 4,0 1.2.4.2 dihydrolipoyl dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8338207&form=6&db=m The expanding clinical spectrum of mitochondrial diseases. causal interaction,unassigned 4,0 1.2.4.2 Eosinophilic Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29669943&form=6&db=m Whole-exome sequencing uncovers oxidoreductases DHTKD1 and OGDHL as linkers between mitochondrial dysfunction and eosinophilic esophagitis. unassigned - 1.2.4.2 Eosinophilic Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30847859&form=6&db=m Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Both Generate Superoxide/H2O2 in a Side Reaction and Each Could Contribute to Oxidative Stress in Mitochondria. causal interaction,unassigned 4,0 1.2.4.2 Eosinophilic Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32633484&form=6&db=m Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex. unassigned - 1.2.4.2 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30890077&form=6&db=m Triheptanoin alters [U-13C6]-glucose incorporation into glycolytic intermediates and increases TCA cycling by normalizing the activities of pyruvate dehydrogenase and oxoglutarate dehydrogenase in a chronic epilepsy mouse model. ongoing research,unassigned 1,0 1.2.4.2 Fragile X Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15465491&form=6&db=m Identification of distinct genes with restricted expression in the somitic mesoderm in Xenopus embryo. unassigned - 1.2.4.2 Friedreich Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=179005&form=6&db=m Low activities of the pyruvate and oxoglutarate dehydrogenase complexes in five patients with Friedreich's ataxia. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 1.2.4.2 Friedreich Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8731379&form=6&db=m Immunoreactive levels of alpha-ketoglutarate dehydrogenase subunits in Friedreich's ataxia and spinocerebellar ataxia type 1. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 1.2.4.2 fumarate hydratase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8338207&form=6&db=m The expanding clinical spectrum of mitochondrial diseases. causal interaction,unassigned 4,0 1.2.4.2 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6936873&form=6&db=m Studies on alpha-ketoglutaric aciduria in type I glycogenosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 1.2.4.2 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31146816&form=6&db=m Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway. diagnostic usage,ongoing research,unassigned 3,1,0 1.2.4.2 Hemangioma, Cavernous, Central Nervous System http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28387648&form=6&db=m Dysmorphic features, frontal cerebral cavernoma and hyperglycemia in a girl with a de novo deletion of 7.23 Mb in region 7p13-p12.1. causal interaction,unassigned 4,0 1.2.4.2 Hepatic Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3760866&form=6&db=m Brain alpha-ketoglutarate dehydrogenase complex: kinetic properties, regional distribution, and effects of inhibitors. causal interaction,unassigned 1,0 1.2.4.2 Hepatic Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8474555&form=6&db=m The two catalytic components of the 2-oxoglutarate dehydrogenase complex in rat cerebral synaptic and nonsynaptic mitochondria: comparison of the response to in vitro treatment with ammonia, hyperammonemia, and hepatic encephalopathy. ongoing research,therapeutic application,unassigned 2,1,0 1.2.4.2 Hepatolenticular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15122704&form=6&db=m Cu2+ toxicity inhibition of mitochondrial dehydrogenases in vitro and in vivo. ongoing research,unassigned 2,0 1.2.4.2 Hepatolenticular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16563643&form=6&db=m Free radical-mediated neurotoxicity may be caused by inhibition of mitochondrial dehydrogenases in vitro and in vivo. ongoing research,unassigned 2,0 1.2.4.2 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15009635&form=6&db=m Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity. causal interaction,unassigned 4,0 1.2.4.2 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30847859&form=6&db=m Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Both Generate Superoxide/H2O2 in a Side Reaction and Each Could Contribute to Oxidative Stress in Mitochondria. causal interaction,unassigned 4,0 1.2.4.2 Hyperlactatemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1640293&form=6&db=m Alpha-ketoglutarate dehydrogenase deficiency presenting as congenital lactic acidosis. causal interaction,unassigned 4,0 1.2.4.2 Hyperparathyroidism, Secondary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1956483&form=6&db=m Impaired activity of alpha-ketoglutarate dehydrogenase of heart mitochondria in chronic renal failure: role of secondary hyperparathyroidism. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 1.2.4.2 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8467960&form=6&db=m Effects of hyperthyroidism on glucose, glutamine and ketone-body metabolism in the gut of the rat. unassigned - 1.2.4.2 Hypokinesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2329762&form=6&db=m [Activity of various oxidases and transaminases in the rat liver in the readaptation period after hypokinesia up to 30 days] unassigned - 1.2.4.2 Hypokinesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2593611&form=6&db=m [Changes in the mitochondrial oxidative enzyme activity in the skeletal muscles od rats during the recovery period after hypokinesia of varying duration] diagnostic usage,unassigned 3,0 1.2.4.2 Hypokinesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6843075&form=6&db=m [Activity of oxidative enzymes of the tricarboxylic acid cycle in the liver of rats during hypokinesia] causal interaction,unassigned 1,0 1.2.4.2 Hypokinesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7176503&form=6&db=m [Oxidative enzyme activity of the tricarboxylic acid cycle in rat skeletal muscles in hypokinesia] unassigned - 1.2.4.2 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16413626&form=6&db=m Activities of membrane bound phosphatases, transaminases and mitochondrial enzymes in white spot syndrome virus infected tissues of Fenneropenaeus indicus. diagnostic usage,ongoing research,unassigned 1,1,0 1.2.4.2 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30951392&form=6&db=m Emerging views of mitophagy in immunity and autoimmune diseases. unassigned - 1.2.4.2 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30065264&form=6&db=m GM-CSF driven myeloid cells in adipose tissue link weight gain and insulin resistance via formation of 2-aminoadipate. causal interaction,unassigned 3,0 1.2.4.2 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31454789&form=6&db=m 2-Aminoadipic acid protects against obesity and diabetes. diagnostic usage,unassigned 3,0 1.2.4.2 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15465491&form=6&db=m Identification of distinct genes with restricted expression in the somitic mesoderm in Xenopus embryo. unassigned - 1.2.4.2 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1956483&form=6&db=m Impaired activity of alpha-ketoglutarate dehydrogenase of heart mitochondria in chronic renal failure: role of secondary hyperparathyroidism. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 1.2.4.2 Korsakoff Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8279670&form=6&db=m Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wernicke-Korsakoff syndrome. causal interaction,diagnostic usage,unassigned 2,3,0 1.2.4.2 Korsakoff Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11445257&form=6&db=m No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome. causal interaction,unassigned 2,0 1.2.4.2 Leigh Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24341803&form=6&db=m Mutations in human lipoyltransferase gene LIPT1 cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase. causal interaction,unassigned 3,0 1.2.4.2 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1380527&form=6&db=m Demonstration of peptide-specific and cross-reactive epitopes in proteins reacting with antimitochondrial antibodies of primary biliary cirrhosis. therapeutic application,unassigned 1,0 1.2.4.2 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1703233&form=6&db=m Sjögren's syndrome and primary biliary cirrhosis: presence of autoantibodies to purified mitochondrial 2-OXO acid dehydrogenases. diagnostic usage,ongoing research,unassigned 1,2,0 1.2.4.2 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1797026&form=6&db=m Specific reactivity of recombinant human PDC-E1 alpha in primary biliary cirrhosis. diagnostic usage,unassigned 2,0 1.2.4.2 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2188870&form=6&db=m Antibodies against mitochondrial dehydrogenase complexes in primary biliary cirrhosis. diagnostic usage,unassigned 2,0 1.2.4.2 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2365294&form=6&db=m Inhibition of alpha-ketoglutarate dehydrogenase activity by a distinct population of autoantibodies recognizing dihydrolipoamide succinyltransferase in primary biliary cirrhosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,3 1.2.4.2 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2673968&form=6&db=m Frequency of IgG and IgM autoantibodies to four specific M2 mitochondrial autoantigens in primary biliary cirrhosis. diagnostic usage,ongoing research,unassigned 3,2,0 1.2.4.2 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7683589&form=6&db=m Sera from patients with tuberculosis recognize the M2a-epitope (E2-subunit of pyruvate dehydrogenase) specific for primary biliary cirrhosis. diagnostic usage,therapeutic application,unassigned 3,1,0 1.2.4.2 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8527402&form=6&db=m Establishment and structural analysis of human mAb to the E2 component of the 2-oxoglutarate dehydrogenase complex generated from a patient with primary biliary cirrhosis. diagnostic usage,ongoing research,unassigned 3,4,0 1.2.4.2 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8617422&form=6&db=m Epitope mapping and reactivity of autoantibodies to the E2 component of 2-oxoglutarate dehydrogenase complex in primary biliary cirrhosis using recombinant 2-oxoglutarate dehydrogenase complex. diagnostic usage,ongoing research,unassigned 3,2,0 1.2.4.2 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9620315&form=6&db=m Immunoreactivity of porcine heart dihydrolipoamide acetyl- and succinyl-transferases (PDC-E2, OGDC-E2) with primary biliary cirrhosis sera: characterization of the autoantigenic region and effects of enzymatic delipoylation and relipoylation. causal interaction,diagnostic usage,unassigned 1,3,0 1.2.4.2 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10094940&form=6&db=m Autoepitope mapping and reactivity of autoantibodies to the dihydrolipoamide dehydrogenase-binding protein (E3BP) and the glycine cleavage proteins in primary biliary cirrhosis. diagnostic usage,unassigned 1,0 1.2.4.2 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16129198&form=6&db=m Tubulointerstitial nephritis and Fanconi syndrome in primary biliary cirrhosis. diagnostic usage,unassigned 3,0 1.2.4.2 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30951392&form=6&db=m Emerging views of mitophagy in immunity and autoimmune diseases. unassigned - 1.2.4.2 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10094940&form=6&db=m Autoepitope mapping and reactivity of autoantibodies to the dihydrolipoamide dehydrogenase-binding protein (E3BP) and the glycine cleavage proteins in primary biliary cirrhosis. diagnostic usage,unassigned 1,0 1.2.4.2 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8474555&form=6&db=m The two catalytic components of the 2-oxoglutarate dehydrogenase complex in rat cerebral synaptic and nonsynaptic mitochondria: comparison of the response to in vitro treatment with ammonia, hyperammonemia, and hepatic encephalopathy. ongoing research,therapeutic application,unassigned 2,1,0 1.2.4.2 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31781311&form=6&db=m OGDHL Expression as a Prognostic Biomarker for Liver Cancer Patients. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,4,0 1.2.4.2 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31899205&form=6&db=m OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 1.2.4.2 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16143346&form=6&db=m Modulation of TCA cycle enzymes and electron transport chain systems in experimental lung cancer. unassigned - 1.2.4.2 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18569708&form=6&db=m Effect of mangiferin on benzo(a)pyrene induced lung carcinogenesis in experimental Swiss albino mice. therapeutic application,unassigned 1,0 1.2.4.2 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30951392&form=6&db=m Emerging views of mitophagy in immunity and autoimmune diseases. unassigned - 1.2.4.2 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6145796&form=6&db=m Absence of alpha-ketoglutarate dehydrogenase activity and presence of CO2-fixing activity in Plasmodium falciparum grown in vitro in human erythrocytes. ongoing research,unassigned 3,0 1.2.4.2 Maple Syrup Urine Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6897145&form=6&db=m Congenital lactic acidosis, alpha-ketoglutaric aciduria and variant form of maple syrup urine disease due to a single enzyme defect: dihydrolipoyl dehydrogenase deficiency. causal interaction,unassigned 4,0 1.2.4.2 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30951392&form=6&db=m Emerging views of mitophagy in immunity and autoimmune diseases. unassigned - 1.2.4.2 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27544700&form=6&db=m Structural alterations induced by ten disease-causing mutations of human dihydrolipoamide dehydrogenase analyzed by hydrogen/deuterium-exchange mass spectrometry: Implications for the structural basis of E3 deficiency. causal interaction,unassigned 2,0 1.2.4.2 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10812195&form=6&db=m Mechanisms of action of valproate: a commentatory. therapeutic application,unassigned 1,0 1.2.4.2 Movement Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32383294&form=6&db=m A biallelic pathogenic variant in the OGDH gene results in a neurological disorder with features of a mitochondrial disease. causal interaction,unassigned 3,0 1.2.4.2 Muscle Hypotonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1640293&form=6&db=m Alpha-ketoglutarate dehydrogenase deficiency presenting as congenital lactic acidosis. causal interaction,unassigned 4,0 1.2.4.2 Muscle Hypotonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32383294&form=6&db=m A biallelic pathogenic variant in the OGDH gene results in a neurological disorder with features of a mitochondrial disease. causal interaction,unassigned 3,0 1.2.4.2 nadh:ubiquinone reductase (h+-translocating) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15374278&form=6&db=m Studies on the pathogenesis of Parkinson's disease in Japan. causal interaction,unassigned 1,0 1.2.4.2 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31175094&form=6&db=m A Novel Oxoglutarate Dehydrogenase-Like Mediated miR-214/TWIST1 Negative Feedback Loop Inhibits Pancreatic Cancer Growth and Metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.2.4.2 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32064152&form=6&db=m miR-193a-5p promotes pancreatic cancer cell metastasis through SRSF6-mediated alternative splicing of OGDHL and ECM1. unassigned - 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15726365&form=6&db=m Therapeutic effect of tamoxifen and energy-modulating vitamins on carbohydrate-metabolizing enzymes in breast cancer. causal interaction,unassigned 1,0 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18004749&form=6&db=m Structure-function relationships in the 2-oxo acid dehydrogenase family: substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins. unassigned - 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18267359&form=6&db=m Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23152800&form=6&db=m OGDHL is a modifier of AKT-dependent signaling and NF-?B function. causal interaction,unassigned 3,0 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24612826&form=6&db=m A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process. ongoing research,unassigned 3,0 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25270118&form=6&db=m Identification of a metabolic and canonical biomarker signature in Mexican HR+/HER2-, triple positive and triple-negative breast cancer patients. diagnostic usage,therapeutic application,unassigned 4,3,0 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26299868&form=6&db=m [Downregulation of OGDHL expression is associated with promoter hypermethylation in colorectal cancer]. causal interaction,diagnostic usage,unassigned 2,2,0 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27027236&form=6&db=m Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner. unassigned - 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27732861&form=6&db=m Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH. ongoing research,unassigned 3,0 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28396387&form=6&db=m PIK3CA mutant tumors depend on oxoglutarate dehydrogenase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30663084&form=6&db=m Alternol eliminates excessive ATP production by disturbing Krebs cycle in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30904169&form=6&db=m Aberrant hypermethylation of OGDHL gene promoter in sporadic colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30951392&form=6&db=m Emerging views of mitophagy in immunity and autoimmune diseases. unassigned - 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30967137&form=6&db=m The CIMP-high phenotype is associated with energy metabolism alterations in colon adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31175094&form=6&db=m A Novel Oxoglutarate Dehydrogenase-Like Mediated miR-214/TWIST1 Negative Feedback Loop Inhibits Pancreatic Cancer Growth and Metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31511525&form=6&db=m Mitochondrial supercomplex assembly promotes breast and endometrial tumorigenesis by metabolic alterations and enhanced hypoxia tolerance. diagnostic usage,ongoing research,unassigned 1,3,0 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31899205&form=6&db=m OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31982949&form=6&db=m Exclusive neuronal detection of KGDHC-specific subunits in the adult human brain cortex despite pancellular protein lysine succinylation. ongoing research,unassigned 3,0 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32466567&form=6&db=m Activation of Mitochondrial 2-Oxoglutarate Dehydrogenase by Cocarboxylase in Human Lung Adenocarcinoma Cells A549 Is p53/p21-Dependent and Impairs Cellular Redox State, Mimicking the Cisplatin Action. causal interaction,unassigned 1,0 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33405394&form=6&db=m OGDHL closely associates with tumor microenvironment and can serve as a prognostic biomarker for papillary thyroid cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,2,0 1.2.4.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33946784&form=6&db=m Toward an Understanding of the Structural and Mechanistic Aspects of Protein-Protein Interactions in 2-Oxoacid Dehydrogenase Complexes. ongoing research,unassigned 3,0 1.2.4.2 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10672230&form=6&db=m The alpha-ketoglutarate dehydrogenase complex. causal interaction,diagnostic usage,unassigned 4,2,0 1.2.4.2 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29661920&form=6&db=m DHTKD1 Deficiency Causes Charcot-Marie-Tooth Disease in Mice. causal interaction,unassigned 4,0 1.2.4.2 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30847859&form=6&db=m Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Both Generate Superoxide/H2O2 in a Side Reaction and Each Could Contribute to Oxidative Stress in Mitochondria. causal interaction,unassigned 4,0 1.2.4.2 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32035071&form=6&db=m Acute sources of mitochondrial NAD+ during respiratory chain dysfunction. causal interaction,unassigned 2,0 1.2.4.2 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10617112&form=6&db=m Metabolic impairment elicits brain cell type-selective changes in oxidative stress and cell death in culture. causal interaction,ongoing research,unassigned 2,1,0 1.2.4.2 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18381761&form=6&db=m High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease. unassigned - 1.2.4.2 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26923918&form=6&db=m Mild mitochondrial metabolic deficits by ?-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease. unassigned - 1.2.4.2 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100191787&form=6&db=m Sensitivity to thiamine deficiency in cultured human cells is dependent on cell type and is enhanced in cells from thiamine-responsive megaloblastic anemia patients. diagnostic usage,ongoing research,unassigned 3,2,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7995856&form=6&db=m Distribution of the alpha-ketoglutarate dehydrogenase complex in rat brain. unassigned - 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10610692&form=6&db=m Quantitative alpha-ketoglutarate dehydrogenase activity staining in brain sections and in cultured cells. causal interaction,diagnostic usage,unassigned 3,1,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10672231&form=6&db=m Oxidative stress and a key metabolic enzyme in Alzheimer brains, cultured cells, and an animal model of chronic oxidative deficits. causal interaction,therapeutic application,unassigned 4,3,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10676873&form=6&db=m The alpha-ketoglutarate dehydrogenase complex in neurodegeneration. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11124972&form=6&db=m Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress. causal interaction,therapeutic application,unassigned 4,3,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11859932&form=6&db=m Selective loss of KGDHC-enriched neurons in Alzheimer temporal cortex: does mitochondrial variation contribute to selective vulnerability? ongoing research,unassigned 3,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15009635&form=6&db=m Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity. causal interaction,unassigned 4,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15377868&form=6&db=m Mitochondrial enzymes and endoplasmic reticulum calcium stores as targets of oxidative stress in neurodegenerative diseases. causal interaction,unassigned 4,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15456945&form=6&db=m Mitochondrial enzymes in schizophrenia. unassigned - 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15649899&form=6&db=m Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15663478&form=6&db=m Inhibition of the alpha-ketoglutarate dehydrogenase complex by the myeloperoxidase products, hypochlorous acid and mono-N-chloramine. causal interaction,therapeutic application,unassigned 4,2,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15840571&form=6&db=m Bioenergetics in glutaryl-coenzyme A dehydrogenase deficiency: a role for glutaryl-coenzyme A. causal interaction,therapeutic application,unassigned 4,1,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15953811&form=6&db=m The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration. causal interaction,therapeutic application,unassigned 4,1,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16060664&form=6&db=m Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. unassigned - 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16321804&form=6&db=m Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19393030&form=6&db=m Mild reduction in the activity of the alpha-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis. therapeutic application,unassigned 2,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19660549&form=6&db=m Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins. causal interaction,unassigned 3,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19715758&form=6&db=m Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. causal interaction,therapeutic application,unassigned 3,4,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21049004&form=6&db=m Behavioral impact of the regulation of the brain 2-oxoglutarate dehydrogenase complex by synthetic phosphonate analog of 2-oxoglutarate: implications into the role of the complex in neurodegenerative diseases. unassigned - 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21454586&form=6&db=m Inactivation and reactivation of the mitochondrial {alpha}-ketoglutarate dehydrogenase complex. causal interaction,therapeutic application,unassigned 4,4,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22719765&form=6&db=m Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced ?-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species. causal interaction,ongoing research,unassigned 1,1,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22820180&form=6&db=m An update on the role of mitochondrial ?-ketoglutarate dehydrogenase in oxidative stress. causal interaction,unassigned 3,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27580471&form=6&db=m Reductions in the mitochondrial enzyme ?-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental? causal interaction,unassigned 4,0 1.2.4.2 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30847859&form=6&db=m Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Both Generate Superoxide/H2O2 in a Side Reaction and Each Could Contribute to Oxidative Stress in Mitochondria. causal interaction,unassigned 4,0 1.2.4.2 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29777685&form=6&db=m Thiamine preserves mitochondrial function in a rat model of traumatic brain injury, preventing inactivation of the 2-oxoglutarate dehydrogenase complex. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 1.2.4.2 Olivopontocerebellar Atrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7910005&form=6&db=m Cerebellar alpha-ketoglutarate dehydrogenase activity is reduced in spinocerebellar ataxia type 1. causal interaction,diagnostic usage,unassigned 3,3,0 1.2.4.2 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30263935&form=6&db=m Regulation of protein metabolism in cancer. causal interaction,therapeutic application,unassigned 2,1,0 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1640293&form=6&db=m Alpha-ketoglutarate dehydrogenase deficiency presenting as congenital lactic acidosis. causal interaction,unassigned 4,0 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2085168&form=6&db=m Measurement of alpha-ketoglutarate dehydrogenase activity in tissue extracts and human platelets using reversed-phase high-performance liquid chromatography. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8295396&form=6&db=m 2-Ketoglutarate dehydrogenase deficiency, a rare cause of primary hyperlactataemia: report of a new case. causal interaction,unassigned 4,0 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8338207&form=6&db=m The expanding clinical spectrum of mitochondrial diseases. causal interaction,unassigned 4,0 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8884572&form=6&db=m Metabolic intermediates in lactic acidosis: compounds, samples and interpretation. unassigned - 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9062896&form=6&db=m Expression of oxidative phosphorylation genes in muscle cell cultures from patients with mitochondrial myopathies. diagnostic usage,ongoing research,unassigned 3,3,0 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9489735&form=6&db=m Immunochemical characterization of the deficiency of the alpha-ketoglutarate dehydrogenase complex in thiamine-deficient rat brain. unassigned - 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10672230&form=6&db=m The alpha-ketoglutarate dehydrogenase complex. causal interaction,diagnostic usage,unassigned 4,2,0 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10676873&form=6&db=m The alpha-ketoglutarate dehydrogenase complex in neurodegeneration. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10774994&form=6&db=m 2-ketoglutarate dehydrogenase deficiency with intermittent 2-ketoglutaric aciduria. causal interaction,unassigned 4,0 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12013995&form=6&db=m [Alpha-ketoglutarate dehydrogenase deficiency] causal interaction,unassigned 4,0 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15712224&form=6&db=m A novel mutation in the dihydrolipoamide dehydrogenase E3 subunit gene (DLD) resulting in an atypical form of alpha-ketoglutarate dehydrogenase deficiency. causal interaction,unassigned 4,0 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28387648&form=6&db=m Dysmorphic features, frontal cerebral cavernoma and hyperglycemia in a girl with a de novo deletion of 7.23 Mb in region 7p13-p12.1. causal interaction,unassigned 4,0 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29661920&form=6&db=m DHTKD1 Deficiency Causes Charcot-Marie-Tooth Disease in Mice. causal interaction,unassigned 4,0 1.2.4.2 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31175094&form=6&db=m A Novel Oxoglutarate Dehydrogenase-Like Mediated miR-214/TWIST1 Negative Feedback Loop Inhibits Pancreatic Cancer Growth and Metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.2.4.2 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32064152&form=6&db=m miR-193a-5p promotes pancreatic cancer cell metastasis through SRSF6-mediated alternative splicing of OGDHL and ECM1. unassigned - 1.2.4.2 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33674273&form=6&db=m Integrative Genomic Analysis of Gemcitabine Resistance in Pancreatic Cancer by Patient-derived Xenograft Models. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 1.2.4.2 Paramyxoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30951392&form=6&db=m Emerging views of mitophagy in immunity and autoimmune diseases. unassigned - 1.2.4.2 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7662887&form=6&db=m Inhibition of alpha-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). causal interaction,unassigned 2,0 1.2.4.2 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8109900&form=6&db=m An immunohistochemical study on alpha-ketoglutarate dehydrogenase complex in Parkinson's disease. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 1.2.4.2 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8651949&form=6&db=m The isomers of thioctic acid alter C-deoxyglucose incorporation in rat basal ganglia. causal interaction,unassigned 1,0 1.2.4.2 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8986127&form=6&db=m Mitochondrial respiratory enzyme function and superoxide dismutase activity following brain glutathione depletion in the rat. unassigned - 1.2.4.2 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9450778&form=6&db=m Association between the gene encoding the E2 subunit of the alpha-ketoglutarate dehydrogenase complex and Parkinson's disease. unassigned - 1.2.4.2 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10471207&form=6&db=m Cerebrospinal fluid levels of thiamine in patients with Parkinson's disease. causal interaction,unassigned 3,0 1.2.4.2 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10676873&form=6&db=m The alpha-ketoglutarate dehydrogenase complex in neurodegeneration. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.2.4.2 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11041275&form=6&db=m Oxidative metabolites of 5-S-cysteinyldopamine inhibit the alpha-ketoglutarate dehydrogenase complex: possible relevance to the pathogenesis of Parkinson's disease. causal interaction,unassigned 1,0 1.2.4.2 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12963742&form=6&db=m Oxidative alpha-ketoglutarate dehydrogenase inhibition via subtle elevations in monoamine oxidase B levels results in loss of spare respiratory capacity: implications for Parkinson's disease. causal interaction,therapeutic application,unassigned 4,1,0 1.2.4.2 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15009635&form=6&db=m Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity. causal interaction,unassigned 4,0 1.2.4.2 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30847859&form=6&db=m Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Both Generate Superoxide/H2O2 in a Side Reaction and Each Could Contribute to Oxidative Stress in Mitochondria. causal interaction,unassigned 4,0 1.2.4.2 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30951392&form=6&db=m Emerging views of mitophagy in immunity and autoimmune diseases. unassigned - 1.2.4.2 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30663084&form=6&db=m Alternol eliminates excessive ATP production by disturbing Krebs cycle in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 1.2.4.2 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30967137&form=6&db=m The CIMP-high phenotype is associated with energy metabolism alterations in colon adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 1.2.4.2 Refsum Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16737698&form=6&db=m Brain pyruvate and 2-oxoglutarate dehydrogenase complexes are mitochondrial targets of the CoA ester of the Refsum disease marker phytanic acid. unassigned - 1.2.4.2 Respiratory Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2016073&form=6&db=m Characterization of oxygen-resistant Chinese hamster ovary cells. III. Relative resistance of succinate and alpha-ketoglutarate dehydrogenases to hyperoxic inactivation. unassigned - 1.2.4.2 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3724963&form=6&db=m Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy. 2. alpha-Ketoglutarate dehydrogenase. causal interaction,therapeutic application,unassigned 4,1,0 1.2.4.2 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6280937&form=6&db=m Problems in the congenital lactic acidoses. causal interaction,therapeutic application,unassigned 3,1,0 1.2.4.2 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7910005&form=6&db=m Cerebellar alpha-ketoglutarate dehydrogenase activity is reduced in spinocerebellar ataxia type 1. causal interaction,diagnostic usage,unassigned 3,3,0 1.2.4.2 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8731379&form=6&db=m Immunoreactive levels of alpha-ketoglutarate dehydrogenase subunits in Friedreich's ataxia and spinocerebellar ataxia type 1. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 1.2.4.2 Spinocerebellar Degenerations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=106330&form=6&db=m Pyruvate dehydrogenase deficiency in spinocerebellar degenerations. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.2.4.2 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1764500&form=6&db=m Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by lungs of the rat. causal interaction,unassigned 4,0 1.2.4.2 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1982377&form=6&db=m [Features of the interconversion of alpha-ketoglutarate--glutamate in brain mitochondria of exothermic animals during hibernation] causal interaction,unassigned 3,0 1.2.4.2 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7092823&form=6&db=m Studies on the interactions of Ca2+ and pyruvate in the regulation of rat heart pyruvate dehydrogenase activity. Effects of starvation and diabetes. ongoing research,unassigned 4,0 1.2.4.2 Stomach Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9495749&form=6&db=m Helicobacter pylori porCDAB and oorDABC genes encode distinct pyruvate:flavodoxin and 2-oxoglutarate:acceptor oxidoreductases which mediate electron transport to NADP. unassigned - 1.2.4.2 Thiamine Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2675860&form=6&db=m Effects of thiamine deficiency on brain metabolism: implications for the pathogenesis of the Wernicke-Korsakoff syndrome. causal interaction,unassigned 4,0 1.2.4.2 Thiamine Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4074790&form=6&db=m [Characteristics of carbohydrate metabolism in the rat liver in thiamine deficiency] causal interaction,therapeutic application,unassigned 3,1,0 1.2.4.2 Thiamine Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5549558&form=6&db=m [The activity of 2-oxoacid-dehydrogenases in thiamine deficiency of the rat, with a contribution to the activity measurement of oxoglutarate dehydrogenase] diagnostic usage,ongoing research,unassigned 3,3,0 1.2.4.2 Thiamine Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8683340&form=6&db=m Thiamine pyrophosphate-requiring enzymes are altered during pyrithiamine-induced thiamine deficiency in cultured human lymphoblasts. causal interaction,unassigned 1,0 1.2.4.2 Thiamine Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9521628&form=6&db=m Thiamine deficiency decreases steady-state transketolase and pyruvate dehydrogenase but not alpha-ketoglutarate dehydrogenase mRNA levels in three human cell types. ongoing research,unassigned 3,0 1.2.4.2 Thiamine Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11445257&form=6&db=m No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome. causal interaction,unassigned 2,0 1.2.4.2 Thiamine Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15663478&form=6&db=m Inhibition of the alpha-ketoglutarate dehydrogenase complex by the myeloperoxidase products, hypochlorous acid and mono-N-chloramine. causal interaction,therapeutic application,unassigned 4,2,0 1.2.4.2 Thiamine Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15953809&form=6&db=m Role of mitochondrial dysfunction and oxidative stress in the pathogenesis of selective neuronal loss in Wernicke's encephalopathy. causal interaction,unassigned 1,0 1.2.4.2 Thiamine Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16840290&form=6&db=m Pathophysiologic mechanisms responsible for the reversible (thiamine-responsive) and irreversible (thiamine non-responsive) neurological symptoms of Wernicke's encephalopathy. unassigned - 1.2.4.2 Thiamine Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17482317&form=6&db=m Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability. causal interaction,unassigned 4,0 1.2.4.2 Thiamine Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19067139&form=6&db=m Thiamine deficiency-related brain dysfunction in chronic liver failure. unassigned - 1.2.4.2 Thiamine Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21517848&form=6&db=m Chronic alcoholism in rats induces a compensatory response, preserving brain thiamine diphosphate, but the brain 2-oxo acid dehydrogenases are inactivated despite unchanged coenzyme levels. unassigned - 1.2.4.2 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33405394&form=6&db=m OGDHL closely associates with tumor microenvironment and can serve as a prognostic biomarker for papillary thyroid cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,2,0 1.2.4.2 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16045627&form=6&db=m Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. unassigned - 1.2.4.2 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16522631&form=6&db=m Corynebacterial protein kinase G controls 2-oxoglutarate dehydrogenase activity via the phosphorylation status of the OdhI protein. unassigned - 1.2.4.2 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19936047&form=6&db=m An anaerobic-type alpha-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis. therapeutic application,unassigned 1,0 1.2.4.2 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21867916&form=6&db=m Functional Plasticity and Allosteric Regulation of ?-Ketoglutarate Decarboxylase in Central Mycobacterial Metabolism. unassigned - 1.2.4.2 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25750047&form=6&db=m The glyoxylate shunt is essential for CO2-requiring oligotrophic growth of Rhodococcus erythropolis N9T-4. diagnostic usage,unassigned 1,0 1.2.4.2 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23152800&form=6&db=m OGDHL is a modifier of AKT-dependent signaling and NF-?B function. causal interaction,unassigned 3,0 1.2.4.2 Wernicke Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3724963&form=6&db=m Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy. 2. alpha-Ketoglutarate dehydrogenase. causal interaction,therapeutic application,unassigned 4,1,0