1.14.99.38 abc-type xenobiotic transporter deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33137324&form=6&db=m P-glycoprotein deficiency enhances metabolic activation of and platelet response to clopidogrel through marked up-regulation of Cyp3a11 in mice: Direct evidence for the interplay between P-glycoprotein and Cyp3a. causal interaction,unassigned 4,0 1.14.99.38 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17239366&form=6&db=m Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver. ongoing research,unassigned 4,0 1.14.99.38 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28794002&form=6&db=m KLF4 Regulation of Ch25h and LXR Mitigates Atherosclerosis Susceptibility. causal interaction,therapeutic application,unassigned 2,1,0 1.14.99.38 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33193099&form=6&db=m Downregulation of Cyp7a1 by Cholic Acid and Chenodeoxycholic Acid in Cyp27a1/ApoE Double Knockout Mice: Differential Cardiovascular Outcome. ongoing research,unassigned 4,0 1.14.99.38 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29033131&form=6&db=m Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 1.14.99.38 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16381673&form=6&db=m The role of pregnane x receptor in 2-acetylaminofluorene-mediated induction of drug transport and -metabolizing enzymes in mice. ongoing research,therapeutic application,unassigned 3,1,0 1.14.99.38 cholesterol 25-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29033131&form=6&db=m Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 1.14.99.38 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30742043&form=6&db=m The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis. ongoing research,unassigned 2,0 1.14.99.38 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31220227&form=6&db=m The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 1.14.99.38 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32859970&form=6&db=m Cholesterol 25-hydroxylase protects against experimental colitis in mice by modulating epithelial gut barrier function. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 1.14.99.38 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33998600&form=6&db=m Regulation of intercellular biomolecule transfer-driven tumor angiogenesis and responses to anticancer therapies. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 1.14.99.38 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33318199&form=6&db=m Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis. therapeutic application,unassigned 1,0 1.14.99.38 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25456971&form=6&db=m Oxysterols regulate encephalitogenic CD4(+) T cell trafficking during central nervous system autoimmunity. therapeutic application,unassigned 1,0 1.14.99.38 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25456971&form=6&db=m Oxysterols regulate encephalitogenic CD4(+) T cell trafficking during central nervous system autoimmunity. therapeutic application,unassigned 1,0 1.14.99.38 Gastroenteritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30955800&form=6&db=m Cholesterol 25-hydroxylase negatively regulates porcine intestinal coronavirus replication by the production of 25-hydroxycholesterol. causal interaction,therapeutic application,unassigned 4,1,0 1.14.99.38 Gastroenteritis, Transmissible, of Swine http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30955800&form=6&db=m Cholesterol 25-hydroxylase negatively regulates porcine intestinal coronavirus replication by the production of 25-hydroxycholesterol. causal interaction,therapeutic application,unassigned 4,1,0 1.14.99.38 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25467815&form=6&db=m Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms. causal interaction,therapeutic application,unassigned 3,2,0 1.14.99.38 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25999047&form=6&db=m Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.14.99.38 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28404225&form=6&db=m Herpes simplex virus type 1 abrogates the antiviral activity of Ch25h via its virion host shutoff protein. diagnostic usage,ongoing research,unassigned 1,2,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20719939&form=6&db=m Modulation of hepatic cytochrome P450s by citrobacter rodentium infection in interleukin-6- and interferon-{gamma}-null mice. ongoing research,therapeutic application,unassigned 4,1,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21263022&form=6&db=m Listeria monocytogenes Infection Induces Prosurvival Metabolic Signaling in Macrophages. causal interaction,unassigned 3,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21570957&form=6&db=m Selective role for tumor necrosis factor-?, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21959890&form=6&db=m Downregulation of Hepatic Cytochrome P450 3A in Mice Infected with Babesia microti. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24707356&form=6&db=m Selective effects of a therapeutic protein targeting tumor necrosis factor-alpha on cytochrome P450 regulation during infectious colitis: Implications for disease-dependent drug-drug interactions. ongoing research,therapeutic application,unassigned 4,3,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24994901&form=6&db=m 25-Hydroxycholesterol acts as an amplifier of inflammatory signaling. causal interaction,unassigned 1,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25467815&form=6&db=m Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms. causal interaction,therapeutic application,unassigned 3,2,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25903345&form=6&db=m Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25999047&form=6&db=m Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27826543&form=6&db=m Endogenous Retrovirus ev21 Dose Not Recombine with ALV-J and Induces the Expression of ISGs in the Host. unassigned - 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28631596&form=6&db=m Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28724759&form=6&db=m Cholesterol 25-Hydroxylase Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication through Enzyme Activity-Dependent and -Independent Mechanisms. causal interaction,therapeutic application,unassigned 1,2,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29103685&form=6&db=m Cholesterol 25-hydroxylase is an interferon-inducible factor that protects against porcine reproductive and respiratory syndrome virus infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,3 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29950420&form=6&db=m 25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection. causal interaction,therapeutic application,unassigned 4,1,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30173739&form=6&db=m Porcine reproductive and respiratory syndrome virus nsp1? and nsp11 antagonize the antiviral activity of cholesterol-25-hydroxylase via lysosomal degradation. causal interaction,unassigned 1,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30309895&form=6&db=m Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,2 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30524435&form=6&db=m Regulating Innate and Adaptive Immunity for Controlling SIV Infection by 25-Hydroxycholesterol. ongoing research,therapeutic application,unassigned 3,1,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30841905&form=6&db=m A balanced game: chicken macrophage response to ALV-J infection. therapeutic application,unassigned 1,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30894855&form=6&db=m Fish Cholesterol 25-Hydroxylase Inhibits Virus Replication via Regulating Interferon Immune Response or Affecting Virus Entry. unassigned - 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30955800&form=6&db=m Cholesterol 25-hydroxylase negatively regulates porcine intestinal coronavirus replication by the production of 25-hydroxycholesterol. causal interaction,therapeutic application,unassigned 4,1,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31151272&form=6&db=m Cholesterol-25-hydroxylase Is a Chicken ISG That Restricts ALV-J Infection by Producing 25-hydroxycholesterol. causal interaction,therapeutic application,unassigned 2,1,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31341055&form=6&db=m Porcine reproductive and respiratory syndrome virus E protein degrades porcine cholesterol 25-hydroxylase via the ubiquitin-proteasome pathway. diagnostic usage,unassigned 3,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31552533&form=6&db=m Cholesterol 25-hydroxylase suppresses rabies virus infection by inhibiting viral entry. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31767082&form=6&db=m Cholesterol 25-Hydroxylase inhibits bovine parainfluenza virus type 3 replication through enzyme activity-dependent and -independent ways. causal interaction,therapeutic application,unassigned 2,1,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32456829&form=6&db=m Cholesterol 25-hydroxylase inhibits encephalomyocarditis virus replication through enzyme activity-dependent and independent mechanisms. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32640529&form=6&db=m Multifaceted Functions of CH25H and 25HC to Modulate the Lipid Metabolism, Immune Responses, and Broadly Antiviral Activities. unassigned - 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33476696&form=6&db=m Cholesterol 25-hydroxylase suppresses porcine deltacoronavirus infection by inhibiting viral entry. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33845332&form=6&db=m Cholesterol 25-hydroxylase inhibits Senecavirus A replication by enzyme activity-dependent and independent mechanisms. diagnostic usage,therapeutic application,unassigned 3,3,0 1.14.99.38 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34057681&form=6&db=m Modulation of Antiviral Immunity and Therapeutic Efficacy by 25-Hydroxycholesterol in Chronically SIV-Infected, ART-Treated Rhesus Macaques. causal interaction,therapeutic application,unassigned 1,1,0 1.14.99.38 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24994901&form=6&db=m 25-Hydroxycholesterol acts as an amplifier of inflammatory signaling. causal interaction,unassigned 1,0 1.14.99.38 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28299341&form=6&db=m Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,2 1.14.99.38 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32229247&form=6&db=m Cholesterol 25-hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes. causal interaction,ongoing research,unassigned 2,2,0 1.14.99.38 Leukodystrophy, Globoid Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34172992&form=6&db=m Expression of Ripk1 and DAM genes correlates with severity and progression of Krabbe disease. causal interaction,ongoing research,unassigned 1,2,0 1.14.99.38 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27760163&form=6&db=m Role of PXR in Hepatic Cancer: Its Influences on Liver Detoxification Capacity and Cancer Progression. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 1.14.99.38 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24281836&form=6&db=m Malaria infection alters the expression of hepatobiliary and placental drug transporters in pregnant mice. causal interaction,unassigned 3,0 1.14.99.38 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22250051&form=6&db=m Identification of TFG (TRK-fused gene) as a putative metastatic melanoma tumor suppressor gene. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 1.14.99.38 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30645975&form=6&db=m An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 1.14.99.38 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34090999&form=6&db=m Extracellular vesicles in cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 1.14.99.38 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26857497&form=6&db=m Analysis of CH25H in multiple sclerosis and neuromyelitis optica. diagnostic usage,ongoing research,unassigned 2,3,0 1.14.99.38 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30645975&form=6&db=m An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 1.14.99.38 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34090999&form=6&db=m Extracellular vesicles in cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 1.14.99.38 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15205385&form=6&db=m Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 1.14.99.38 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18059400&form=6&db=m Downregulation of drug transport and metabolism in mice bearing extra-hepatic malignancies. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 1.14.99.38 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21335546&form=6&db=m Helicobacter hepaticus-Induced Liver Tumor Promotion Is Associated with Increased Serum Bile Acid and a Persistent Microbial-Induced Immune Response. causal interaction,diagnostic usage,unassigned 1,1,0 1.14.99.38 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21570957&form=6&db=m Selective role for tumor necrosis factor-?, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2 1.14.99.38 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26013842&form=6&db=m Skin response to a carcinogen involves the xenobiotic receptor pregnane X receptor. unassigned - 1.14.99.38 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31375561&form=6&db=m IL-1?/TNF-?/IL-6 inflammatory cytokines promote STAT1-dependent induction of CH25H in zika virus-infected human macrophages. ongoing research,unassigned 1,0 1.14.99.38 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32284563&form=6&db=m Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol. causal interaction,therapeutic application,unassigned 4,1,0 1.14.99.38 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33998600&form=6&db=m Regulation of intercellular biomolecule transfer-driven tumor angiogenesis and responses to anticancer therapies. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 1.14.99.38 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34090999&form=6&db=m Extracellular vesicles in cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 1.14.99.38 Neuromyelitis Optica http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26857497&form=6&db=m Analysis of CH25H in multiple sclerosis and neuromyelitis optica. diagnostic usage,ongoing research,unassigned 2,3,0 1.14.99.38 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30120929&form=6&db=m Modulation of xenobiotic nuclear receptors in high-fat diet induced non-alcoholic fatty liver disease. causal interaction,unassigned 1,0 1.14.99.38 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28299341&form=6&db=m Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,2 1.14.99.38 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32229247&form=6&db=m Cholesterol 25-hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes. causal interaction,ongoing research,unassigned 2,2,0 1.14.99.38 Obesity, Metabolically Benign http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28299341&form=6&db=m Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,2 1.14.99.38 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30728500&form=6&db=m The CH25H-CYP7B1-ROR? axis of cholesterol metabolism regulates osteoarthritis. unassigned - 1.14.99.38 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32392916&form=6&db=m Oxysterol 25-hydroxycholesterol as a metabolic pathophysiological factors of osteoarthritis induces apoptosis in primary rat chondrocytes. unassigned - 1.14.99.38 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32395076&form=6&db=m Oxysterol 25-hydroxycholesterol as a metabolic pathophysiological factors of osteoarthritis induces apoptosis in primary rat chondrocytes. unassigned - 1.14.99.38 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25623066&form=6&db=m Functional coupling of ATP binding cassette transporter Abcb6 to Cytochrome P450 expression and activity in liver. unassigned - 1.14.99.38 Porcine Reproductive and Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30173739&form=6&db=m Porcine reproductive and respiratory syndrome virus nsp1? and nsp11 antagonize the antiviral activity of cholesterol-25-hydroxylase via lysosomal degradation. causal interaction,unassigned 1,0 1.14.99.38 Pseudorabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28631596&form=6&db=m Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 1.14.99.38 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23485764&form=6&db=m 25-Hydroxycholesterol promotes fibroblast-mediated tissue remodeling through NF-?B dependent pathway. causal interaction,unassigned 1,0 1.14.99.38 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29674392&form=6&db=m Cholesterol metabolism promotes B-cell positioning during immune pathogenesis of chronic obstructive pulmonary disease. causal interaction,ongoing research,unassigned 3,2,0 1.14.99.38 Rabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31552533&form=6&db=m Cholesterol 25-hydroxylase suppresses rabies virus infection by inhibiting viral entry. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.14.99.38 Reoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29950420&form=6&db=m 25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection. causal interaction,therapeutic application,unassigned 4,1,0 1.14.99.38 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30991873&form=6&db=m The prominent impairment of liver/intestinal cytochrome P450 and intestinal drug transporters in sepsis-induced acute kidney injury over acute and chronic renal ischemia, a mouse model comparison. causal interaction,ongoing research,unassigned 3,3,0 1.14.99.38 Rift Valley Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32640529&form=6&db=m Multifaceted Functions of CH25H and 25HC to Modulate the Lipid Metabolism, Immune Responses, and Broadly Antiviral Activities. unassigned - 1.14.99.38 Sarcoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17189422&form=6&db=m Transcriptional repression of hepatic cytochrome P450 3A4 gene in the presence of cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 1.14.99.38 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33239446&form=6&db=m Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion. therapeutic application,unassigned 1,0 1.14.99.38 Viremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28789986&form=6&db=m Interferon-independent antiviral activity of 25-hydroxycholesterol in a teleost fish. ongoing research,unassigned 3,0 1.14.99.38 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25467815&form=6&db=m Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms. causal interaction,therapeutic application,unassigned 3,2,0 1.14.99.38 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25903345&form=6&db=m Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 1.14.99.38 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29342871&form=6&db=m Interferons: Reprogramming the Metabolic Network against Viral Infection. causal interaction,ongoing research,unassigned 1,1,0 1.14.99.38 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29950420&form=6&db=m 25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection. causal interaction,therapeutic application,unassigned 4,1,0 1.14.99.38 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30309895&form=6&db=m Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,2 1.14.99.38 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30524435&form=6&db=m Regulating Innate and Adaptive Immunity for Controlling SIV Infection by 25-Hydroxycholesterol. ongoing research,therapeutic application,unassigned 3,1,0 1.14.99.38 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30842274&form=6&db=m Hepatitis B Virus-Induced Imbalance of Inflammatory and Antiviral Signaling by Differential Phosphorylation of STAT1 in Human Monocytes. therapeutic application,unassigned 1,0 1.14.99.38 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31767082&form=6&db=m Cholesterol 25-Hydroxylase inhibits bovine parainfluenza virus type 3 replication through enzyme activity-dependent and -independent ways. causal interaction,therapeutic application,unassigned 2,1,0 1.14.99.38 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33548323&form=6&db=m Antiviral activity of porcine interferon delta 8 against pesudorabies virus in vitro. unassigned - 1.14.99.38 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33717065&form=6&db=m Antiviral Actions of 25-Hydroxycholesterol in Fish Vary With the Virus-Host Combination. ongoing research,unassigned 3,0 1.14.99.38 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34061318&form=6&db=m Cholesterol-25-Hydroxylase Suppresses Seneca Valley Virus Infection via Producing 25-Hydroxycholesterol to Block Adsorption Procedure. therapeutic application,unassigned 1,0 1.14.99.38 Zika Virus Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28314593&form=6&db=m 25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model. causal interaction,therapeutic application,unassigned 1,1,0 1.14.99.38 Zika Virus Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31375561&form=6&db=m IL-1?/TNF-?/IL-6 inflammatory cytokines promote STAT1-dependent induction of CH25H in zika virus-infected human macrophages. ongoing research,unassigned 1,0