1.14.14.19 17alpha-hydroxyprogesterone deacetylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9177409&form=6&db=m A 5'-splice site mutation in the cytochrome P450 steroid 17alpha-hydroxylase gene in 17alpha-hydroxylase deficiency. causal interaction,unassigned 4,0 1.14.14.19 17alpha-hydroxyprogesterone deacetylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11549876&form=6&db=m New compound heterozygous mutation in the CYP17 gene in a 46,XY girl with 17 alpha-hydroxylase/17,20-lyase deficiency. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 1.14.14.19 17alpha-hydroxyprogesterone deacetylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12466376&form=6&db=m Differential inhibition of 17alpha-hydroxylase and 17,20-lyase activities by three novel missense CYP17 mutations identified in patients with P450c17 deficiency. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 1.14.14.19 17alpha-hydroxyprogesterone deacetylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12706306&form=6&db=m A complex heterozygous mutation of His373Leu and Asp487-Ser488-Phe489 deletion in human cytochrome P450c17 causes 17alpha-hydroxylase/17,20-lyase deficiency in three Chinese sisters. causal interaction,ongoing research,unassigned 4,1,0 1.14.14.19 17alpha-hydroxyprogesterone deacetylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14504283&form=6&db=m CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding. causal interaction,unassigned 3,0 1.14.14.19 17alpha-hydroxyprogesterone deacetylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19793597&form=6&db=m Novel CYP17A1 mutation in a Japanese patient with combined 17alpha-hydroxylase/17,20-lyase deficiency. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 1.14.14.19 17alpha-hydroxyprogesterone deacetylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21340176&form=6&db=m Distinctive profile of the 17-hydroxylase and 17,20-lyase activities revealed by urinary steroid metabolomes of patients with CYP17 deficiency. causal interaction,diagnostic usage,unassigned 3,1,0 1.14.14.19 Addison Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29982238&form=6&db=m Three new Brazilian cases of 17?-hydroxylase deficiency: clinical, molecular, hormonal, and treatment features. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 1.14.14.19 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8137519&form=6&db=m In-vitro evidence for the regulation of 17,20-lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 1.14.14.19 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8288710&form=6&db=m Mechanism of abnormal production of adrenal androgens in patients with adrenocortical adenomas and carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 1.14.14.19 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8496319&form=6&db=m High expression of cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome associated with high secretion of adrenal androgens. diagnostic usage,ongoing research,unassigned 4,2,0 1.14.14.19 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19454579&form=6&db=m Steroid 17alpha-hydroxylase deficiency: functional characterization of four mutations (A174E, V178D, R440C, L465P) in the CYP17A1 gene. causal interaction,unassigned 4,0 1.14.14.19 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20960109&form=6&db=m Male pseudohermaphroditism as a cause of secondary hypertension: a case report. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 1.14.14.19 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28225307&form=6&db=m 17?-HYDROXYLASE/17, 20-LYASE DEFICIENCY: CLINICAL AND MOLECULAR CHARACTERIZATION OF EIGHT CHINESE PATIENTS. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2 1.14.14.19 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28609197&form=6&db=m The Glu331del mutation in the CYP17A1 gene causes atypical congenital adrenal hyperplasia in a 46,XX female. causal interaction,unassigned 4,0 1.14.14.19 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29858860&form=6&db=m Two rare forms of congenital adrenal hyperplasia, 11? hydroxylase deficiency and 17-hydroxylase/17,20-lyase deficiency, presenting with novel mutations. causal interaction,unassigned 4,0 1.14.14.19 Adrenocortical Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8137519&form=6&db=m In-vitro evidence for the regulation of 17,20-lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 1.14.14.19 Adrenocortical Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8288710&form=6&db=m Mechanism of abnormal production of adrenal androgens in patients with adrenocortical adenomas and carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 1.14.14.19 Adrenocortical Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8496319&form=6&db=m High expression of cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome associated with high secretion of adrenal androgens. diagnostic usage,ongoing research,unassigned 4,2,0 1.14.14.19 Adrenocortical Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16828825&form=6&db=m In vitro effects of brominated flame retardants and metabolites on CYP17 catalytic activity: a novel mechanism of action? ongoing research,unassigned 4,0 1.14.14.19 Antley-Bixler Syndrome Phenotype http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15491389&form=6&db=m Abnormal steroidogenesis in three patients with Antley-Bixler syndrome: apparent decreased activity of 17alpha-hydroxylase, 17,20-lyase and 21-hydroxylase. unassigned - 1.14.14.19 Antley-Bixler Syndrome Phenotype http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18559916&form=6&db=m Homozygous mutation G539R in the gene for P450 oxidoreductase in a family previously diagnosed as having 17,20-lyase deficiency. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.14.14.19 aromatase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26862015&form=6&db=m Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic. causal interaction,unassigned 4,0 1.14.14.19 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=161434&form=6&db=m Metabolism of pregnenolone by human breast cancer. Evidence for 17 alpha-hydroxylase and 17,20-lyase. ongoing research,therapeutic application,unassigned 1,1,0 1.14.14.19 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9485002&form=6&db=m Cytochrome P450c17alpha gene (CYP17) polymorphism is associated with serum estrogen and progesterone concentrations. causal interaction,therapeutic application,unassigned 4,1,0 1.14.14.19 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11955795&form=6&db=m Genetic modeling of estrogen metabolism as a risk factor of hormone-dependent disorders. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 1.14.14.19 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12020974&form=6&db=m Genetic modelling of the estrogen metabolism as a risk factor of hormone-dependent disorders. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 1.14.14.19 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12368392&form=6&db=m The risk of breast cancer associated with dietary lignans differs by CYP17 genotype in women. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 1.14.14.19 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15987450&form=6&db=m CYP17 5'-UTR MspA1 polymorphism and the risk of premenopausal breast cancer in a German population-based case-control study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 1.14.14.19 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16702327&form=6&db=m CYP17 genotype modifies the association between lignan supply and premenopausal breast cancer risk in humans. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 1.14.14.19 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20432167&form=6&db=m Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 1.14.14.19 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20798986&form=6&db=m The CYP17A1 -34T > C polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,2,2 1.14.14.19 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22222232&form=6&db=m Human steroid biosynthesis for the oncologist. causal interaction,therapeutic application,unassigned 1,4,0 1.14.14.19 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31367790&form=6&db=m A population pharmacokinetic analysis of the oral CYP17 lyase and androgen receptor inhibitor seviteronel in patients with advanced/metastatic castration-resistant prostate cancer or breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2 1.14.14.19 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8288710&form=6&db=m Mechanism of abnormal production of adrenal androgens in patients with adrenocortical adenomas and carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 1.14.14.19 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3494244&form=6&db=m Loss of expression of a differentiated function gene, steroid 17 alpha-hydroxylase, as adrenocortical cells senescence in culture. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 1.14.14.19 Cryptorchidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9360545&form=6&db=m A single amino acid substitution in the putative redox partner-binding site of P450c17 as cause of isolated 17,20-lyase deficiency. causal interaction,unassigned 4,0 1.14.14.19 Cushing Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8137519&form=6&db=m In-vitro evidence for the regulation of 17,20-lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 1.14.14.19 Cushing Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8496319&form=6&db=m High expression of cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome associated with high secretion of adrenal androgens. diagnostic usage,ongoing research,unassigned 4,2,0 1.14.14.19 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11888844&form=6&db=m Decreased steroidogenic enzyme 17,20-lyase and increased 17-hydroxylase activities in type 2 diabetes mellitus. causal interaction,unassigned 3,0 1.14.14.19 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11888844&form=6&db=m Decreased steroidogenic enzyme 17,20-lyase and increased 17-hydroxylase activities in type 2 diabetes mellitus. causal interaction,unassigned 3,0 1.14.14.19 Disorder of Sex Development, 46,XY http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1003059&form=6&db=m Production of male pseudohermaphroditism in rats by two new inhibitors of steroid 17alpha-hydroxylase and C 17-20 lyase. therapeutic application,unassigned 3,0 1.14.14.19 Disorders of Sex Development http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20080843&form=6&db=m Isolated 17,20-lyase deficiency due to the cytochrome b5 mutation W27X. causal interaction,unassigned 4,0 1.14.14.19 Disorders of Sex Development http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20960109&form=6&db=m Male pseudohermaphroditism as a cause of secondary hypertension: a case report. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 1.14.14.19 Disorders of Sex Development http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32051920&form=6&db=m Isolated 17,20-Lyase Deficiency in a CYB5A Mutated Female With Normal Sexual Development and Fertility. causal interaction,therapeutic application,unassigned 4,1,0 1.14.14.19 Dyskinesias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11839369&form=6&db=m Interactive effect of cytochrome P450 17alpha-hydroxylase and dopamine D3 receptor gene polymorphisms on abnormal involuntary movements in chronic schizophrenia. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 1.14.14.19 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15536258&form=6&db=m Cytochrome P450c17alpha 5'-untranslated region *T/C polymorphism in endometriosis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 1.14.14.19 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15749482&form=6&db=m Estrogen receptor alpha dinucleotide repeat and cytochrome P450c17alpha gene polymorphisms are associated with susceptibility to endometriosis. causal interaction,therapeutic application,unassigned 4,1,0 1.14.14.19 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17484509&form=6&db=m Genetic polymorphisms of cytochrome P450cl7alpha (CYP17) and progesterone receptor genes (PROGINS) in the assessment of endometriosis risk. diagnostic usage,ongoing research,unassigned 2,3,0 1.14.14.19 Fetal Growth Retardation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14665706&form=6&db=m A polymorphism in the CYP17 gene and intrauterine fetal growth restriction. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 1.14.14.19 Gonadal Dysgenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18645707&form=6&db=m Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases. causal interaction,diagnostic usage,unassigned 3,4,0 1.14.14.19 Gynecomastia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14504283&form=6&db=m CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding. causal interaction,unassigned 3,0 1.14.14.19 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12971967&form=6&db=m Genetic polymorphisms of steroid hormone metabolizing enzymes and risk of liver cancer in hepatitis C-infected patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 1.14.14.19 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12971967&form=6&db=m Genetic polymorphisms of steroid hormone metabolizing enzymes and risk of liver cancer in hepatitis C-infected patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 1.14.14.19 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1319681&form=6&db=m Studies of adrenal steroidogenic enzymes in guinea pigs. ongoing research,unassigned 2,0 1.14.14.19 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10626547&form=6&db=m The molecular basis of premature adrenarche: an hypothesis. therapeutic application,unassigned 1,0 1.14.14.19 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17222503&form=6&db=m Gender and gonadal status differences in zona reticularis expression in marmoset monkey adrenals: Cytochrome b5 localization with respect to cytochrome P450 17,20-lyase activity. ongoing research,unassigned 2,0 1.14.14.19 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18000308&form=6&db=m Human adrenal corticocarcinoma NCI-H295R cells produce more androgens than NCI-H295A cells and differ in 3beta-hydroxysteroid dehydrogenase type 2 and 17,20 lyase activities. unassigned - 1.14.14.19 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18493139&form=6&db=m Fetal programming of adrenal androgen excess: lessons from a nonhuman primate model of polycystic ovary syndrome. causal interaction,unassigned 4,0 1.14.14.19 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26976652&form=6&db=m Role of cytochrome b5 in the modulation of the enzymatic activities of cytochrome P450 17?-hydroxylase/17,20-lyase (P450 17A1). unassigned - 1.14.14.19 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28000554&form=6&db=m A homodimer model can resolve the conundrum as to how cytochrome P450 oxidoreductase and cytochrome b5 compete for the same binding site on cytochrome P450c17. unassigned - 1.14.14.19 Hirsutism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7852496&form=6&db=m Adrenal androgen excess in women: lack of a role for 17-hydroxylase and 17,20-lyase dysregulation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1 1.14.14.19 Hyperaldosteronism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29255217&form=6&db=m Congenital adrenal hyperplasia causing hypertension: an illustrative review. causal interaction,unassigned 4,0 1.14.14.19 Hyperandrogenism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9429864&form=6&db=m Polycystic ovary syndrome. unassigned - 1.14.14.19 Hyperandrogenism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11095477&form=6&db=m Enzymatic activities of P450c17 stably expressed in fibroblasts from patients with the polycystic ovary syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.14.14.19 Hyperandrogenism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30682387&form=6&db=m Oxidative stress increases the 17,20-lyase-catalyzing activity of adrenal P450c17 through p38? in the development of hyperandrogenism. causal interaction,therapeutic application,unassigned 1,1,0 1.14.14.19 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9429864&form=6&db=m Polycystic ovary syndrome. unassigned - 1.14.14.19 Hyperkalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28008861&form=6&db=m DELAYED DIAGNOSIS OF A 17-HYDROXYLASE/17,20-LYASE DEFICIENT CASE PRESENTED WITH 46,XY FEMALE: LOW NORMAL POTASSIUM CAN ALERT CLINICIAN. causal interaction,diagnostic usage,unassigned 4,2,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8481334&form=6&db=m Diagnosis and treatment of 17-hydroxylase deficiency. causal interaction,unassigned 4,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15713706&form=6&db=m Subtle 17alpha-hydroxylase/17,20-lyase deficiency with homozygous Y201N mutation in an infertile woman. causal interaction,diagnostic usage,unassigned 4,2,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16477341&form=6&db=m Seventeen Alpha-hydroxylase Deficiency. causal interaction,therapeutic application,unassigned 3,3,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18645707&form=6&db=m Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases. causal interaction,diagnostic usage,unassigned 3,4,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20170344&form=6&db=m 17-alpha-Hydroxylase deficiency: a case report with clinical and molecular analysis. causal interaction,unassigned 4,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20960109&form=6&db=m Male pseudohermaphroditism as a cause of secondary hypertension: a case report. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23291414&form=6&db=m Identifying a novel mutation of CYP17A1 gene from five Chinese 17?-hydroxylase/17, 20-lyase deficiency patients. causal interaction,ongoing research,unassigned 4,2,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24485502&form=6&db=m Fertility in patients with genetic deficiencies of cytochrome P450c17 (CYP17A1): combined 17-hydroxylase/17,20-lyase deficiency and isolated 17,20-lyase deficiency. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26543560&form=6&db=m 17-hydroxylase/17,20-lyase deficiency due to a R96Q mutation causing hypertension and poor breast development. causal interaction,unassigned 4,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26862015&form=6&db=m Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic. causal interaction,unassigned 4,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28008861&form=6&db=m DELAYED DIAGNOSIS OF A 17-HYDROXYLASE/17,20-LYASE DEFICIENT CASE PRESENTED WITH 46,XY FEMALE: LOW NORMAL POTASSIUM CAN ALERT CLINICIAN. causal interaction,diagnostic usage,unassigned 4,2,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28225307&form=6&db=m 17?-HYDROXYLASE/17, 20-LYASE DEFICIENCY: CLINICAL AND MOLECULAR CHARACTERIZATION OF EIGHT CHINESE PATIENTS. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29255217&form=6&db=m Congenital adrenal hyperplasia causing hypertension: an illustrative review. causal interaction,unassigned 4,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29556032&form=6&db=m Common variant rs11191548 near the CYP17A1 gene is associated with hypertension and the serum 25(OH) D levels in Han Chinese. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29595516&form=6&db=m A rare cause of congenital adrenal hyperplasia: Clinical and genetic findings and follow-up characteristics of six patients with 17- hydroxylase deficiency and two novel mutations. causal interaction,unassigned 3,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29880708&form=6&db=m MECHANISMS IN ENDOCRINOLOGY: Rare defects in adrenal steroidogenesis. causal interaction,unassigned 4,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29982238&form=6&db=m Three new Brazilian cases of 17?-hydroxylase deficiency: clinical, molecular, hormonal, and treatment features. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32960117&form=6&db=m Association of the CYP17 and CYP19 gene polymorphisms in women with polycystic ovary syndrome from Punjab, Pakistan. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33304598&form=6&db=m Incidental diagnosis of 17 alpha-hydroxylase deficiency: a case report. causal interaction,diagnostic usage,unassigned 4,2,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33780934&form=6&db=m Genotypic Sex and Severity of the Disease Determine the Time of Clinical Presentation in Steroid 17?-Hydroxylase/17,20-Lyase Deficiency. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 1.14.14.19 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34483146&form=6&db=m Identification of a homozygous c.1039C>T (p.R347C) variant in CYP17A1 in a 67-year-old female patient with partial 17?-hydroxylase/17,20-lyase deficiency. unassigned - 1.14.14.19 Hypoaldosteronism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29255217&form=6&db=m Congenital adrenal hyperplasia causing hypertension: an illustrative review. causal interaction,unassigned 4,0 1.14.14.19 Hypogonadism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7951571&form=6&db=m A case of 17 alpha-hydroxylase deficiency with retained menstruation. unassigned - 1.14.14.19 Hypogonadism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12050123&form=6&db=m Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction. diagnostic usage,unassigned 2,0 1.14.14.19 Hypogonadism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15866602&form=6&db=m Isolated 17,20-lyase (desmolase) deficiency in a 46,XX female presenting with delayed puberty. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.14.14.19 Hypogonadism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18645707&form=6&db=m Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases. causal interaction,diagnostic usage,unassigned 3,4,0 1.14.14.19 Hypogonadism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29982238&form=6&db=m Three new Brazilian cases of 17?-hydroxylase deficiency: clinical, molecular, hormonal, and treatment features. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 1.14.14.19 Hypogonadism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32051920&form=6&db=m Isolated 17,20-Lyase Deficiency in a CYB5A Mutated Female With Normal Sexual Development and Fertility. causal interaction,therapeutic application,unassigned 4,1,0 1.14.14.19 Hypokalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8481334&form=6&db=m Diagnosis and treatment of 17-hydroxylase deficiency. causal interaction,unassigned 4,0 1.14.14.19 Hypokalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23291414&form=6&db=m Identifying a novel mutation of CYP17A1 gene from five Chinese 17?-hydroxylase/17, 20-lyase deficiency patients. causal interaction,ongoing research,unassigned 4,2,0 1.14.14.19 Hypokalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24485502&form=6&db=m Fertility in patients with genetic deficiencies of cytochrome P450c17 (CYP17A1): combined 17-hydroxylase/17,20-lyase deficiency and isolated 17,20-lyase deficiency. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 1.14.14.19 Hypokalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26862015&form=6&db=m Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic. causal interaction,unassigned 4,0 1.14.14.19 Hypokalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28008861&form=6&db=m DELAYED DIAGNOSIS OF A 17-HYDROXYLASE/17,20-LYASE DEFICIENT CASE PRESENTED WITH 46,XY FEMALE: LOW NORMAL POTASSIUM CAN ALERT CLINICIAN. causal interaction,diagnostic usage,unassigned 4,2,0 1.14.14.19 Hypokalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28225307&form=6&db=m 17?-HYDROXYLASE/17, 20-LYASE DEFICIENCY: CLINICAL AND MOLECULAR CHARACTERIZATION OF EIGHT CHINESE PATIENTS. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2 1.14.14.19 Hypokalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29858860&form=6&db=m Two rare forms of congenital adrenal hyperplasia, 11? hydroxylase deficiency and 17-hydroxylase/17,20-lyase deficiency, presenting with novel mutations. causal interaction,unassigned 4,0 1.14.14.19 Hypokalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33304598&form=6&db=m Incidental diagnosis of 17 alpha-hydroxylase deficiency: a case report. causal interaction,diagnostic usage,unassigned 4,2,0 1.14.14.19 Hypokalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34483146&form=6&db=m Identification of a homozygous c.1039C>T (p.R347C) variant in CYP17A1 in a 67-year-old female patient with partial 17?-hydroxylase/17,20-lyase deficiency. unassigned - 1.14.14.19 Hypospadias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9112555&form=6&db=m Defects of the testosterone biosynthetic pathway in boys with hypospadias. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 1.14.14.19 Hypospadias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14504283&form=6&db=m CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding. causal interaction,unassigned 3,0 1.14.14.19 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11095477&form=6&db=m Enzymatic activities of P450c17 stably expressed in fibroblasts from patients with the polycystic ovary syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.14.14.19 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28225307&form=6&db=m 17?-HYDROXYLASE/17, 20-LYASE DEFICIENCY: CLINICAL AND MOLECULAR CHARACTERIZATION OF EIGHT CHINESE PATIENTS. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2 1.14.14.19 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15890676&form=6&db=m Haploinsufficiency of cytochrome P450 17alpha-hydroxylase/17,20 lyase (CYP17) causes infertility in male mice. causal interaction,ongoing research,unassigned 4,4,0 1.14.14.19 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31691616&form=6&db=m A rare enzymatic defect, true isolated 17,20-lyase deficiency leading to endocrine disorders and infertility: case report. causal interaction,therapeutic application,unassigned 4,1,0 1.14.14.19 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32051920&form=6&db=m Isolated 17,20-Lyase Deficiency in a CYB5A Mutated Female With Normal Sexual Development and Fertility. causal interaction,therapeutic application,unassigned 4,1,0 1.14.14.19 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32960117&form=6&db=m Association of the CYP17 and CYP19 gene polymorphisms in women with polycystic ovary syndrome from Punjab, Pakistan. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 1.14.14.19 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9922107&form=6&db=m Role of cytochrome P450c17 in polycystic ovary syndrome. unassigned - 1.14.14.19 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10037253&form=6&db=m The treatment of insulin resistance does not improve adrenal cytochrome P450c17alpha enzyme dysregulation in polycystic ovary syndrome. therapeutic application,unassigned 4,0 1.14.14.19 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11095477&form=6&db=m Enzymatic activities of P450c17 stably expressed in fibroblasts from patients with the polycystic ovary syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.14.14.19 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26096606&form=6&db=m No association between CYP17 -34T/C polymorphism and insulin resistance in Thai polycystic ovary syndrome. diagnostic usage,ongoing research,unassigned 1,2,0 1.14.14.19 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14995917&form=6&db=m A possible role of the cytochrome P450c17alpha gene (CYP17) polymorphism in the pathobiology of uterine leiomyomas from black South African women: a pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1 1.14.14.19 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16595228&form=6&db=m Genotype distribution of estrogen receptor-alpha, catechol-O-methyltransferase, and cytochrome P450 17 gene polymorphisms in Caucasian women with uterine leiomyomas. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 1.14.14.19 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18645709&form=6&db=m Association of the CYP17 gene polymorphism with risk for uterine leiomyoma in Brazilian women. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 1.14.14.19 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12971967&form=6&db=m Genetic polymorphisms of steroid hormone metabolizing enzymes and risk of liver cancer in hepatitis C-infected patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 1.14.14.19 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12971967&form=6&db=m Genetic polymorphisms of steroid hormone metabolizing enzymes and risk of liver cancer in hepatitis C-infected patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 1.14.14.19 Methemoglobinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32051920&form=6&db=m Isolated 17,20-Lyase Deficiency in a CYB5A Mutated Female With Normal Sexual Development and Fertility. causal interaction,therapeutic application,unassigned 4,1,0 1.14.14.19 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=161434&form=6&db=m Metabolism of pregnenolone by human breast cancer. Evidence for 17 alpha-hydroxylase and 17,20-lyase. ongoing research,therapeutic application,unassigned 1,1,0 1.14.14.19 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8137519&form=6&db=m In-vitro evidence for the regulation of 17,20-lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 1.14.14.19 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9028871&form=6&db=m cAMP-dependent transactivation involving the homeodomain protein Pbx1. unassigned - 1.14.14.19 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10760835&form=6&db=m CYP17 promotor polymorphism and ovarian cancer risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,1,1 1.14.14.19 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10800765&form=6&db=m Adrenocortical carcinoma manifesting pure primary aldosteronism: a case report and analysis of steroidogenic enzymes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 1.14.14.19 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12933687&form=6&db=m Mouse strain susceptibility to gonadectomy-induced adrenocortical tumor formation correlates with the expression of GATA-4 and luteinizing hormone receptor. unassigned - 1.14.14.19 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15560921&form=6&db=m HPLC-RIA analysis of steroid hormone profile in a virilizing stromal tumor of the ovary. unassigned - 1.14.14.19 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15927351&form=6&db=m Tumor necrosis factor alpha, CYP 17, urokinase, and interleukin 10 gene polymorphisms in postmenopausal women: correlation to bone mineral density and susceptibility to osteoporosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,2,1 1.14.14.19 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18587089&form=6&db=m Cytochrome b5 expression in gonadectomy-induced adrenocortical neoplasms of the domestic ferret (Mustela putorius furo). causal interaction,ongoing research,unassigned 1,1,0 1.14.14.19 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22249003&form=6&db=m Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys. ongoing research,unassigned 4,0 1.14.14.19 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33069834&form=6&db=m Nature-derived anticancer steroids outside cardica glycosides. therapeutic application,unassigned 1,0 1.14.14.19 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14715870&form=6&db=m Polymorphisms in the P450 c17 (17-hydroxylase/17,20-Lyase) and P450 c19 (aromatase) genes: association with serum sex steroid concentrations and bone mineral density in postmenopausal women. causal interaction,therapeutic application,unassigned 4,1,0 1.14.14.19 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15927351&form=6&db=m Tumor necrosis factor alpha, CYP 17, urokinase, and interleukin 10 gene polymorphisms in postmenopausal women: correlation to bone mineral density and susceptibility to osteoporosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,2,1 1.14.14.19 Ovarian Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14747197&form=6&db=m Deficiency of 17,20-lyase causing giant ovarian cysts in a girl and a female phenotype in her 46,XY sister: case report. causal interaction,unassigned 4,0 1.14.14.19 Ovarian Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18645707&form=6&db=m Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases. causal interaction,diagnostic usage,unassigned 3,4,0 1.14.14.19 Ovarian Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28225307&form=6&db=m 17?-HYDROXYLASE/17, 20-LYASE DEFICIENCY: CLINICAL AND MOLECULAR CHARACTERIZATION OF EIGHT CHINESE PATIENTS. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2 1.14.14.19 Ovarian Hyperstimulation Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8943512&form=6&db=m Ovarian hyperstimulation syndrome with low oestradiol in non-classical 17 alpha-hydroxylase, 17,20-lyase deficiency: what is the role of oestrogens? causal interaction,unassigned 4,0 1.14.14.19 Pediatric Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25042470&form=6&db=m Peer group normalization and urine to blood context in steroid metabolomics: the case of CAH and obesity. diagnostic usage,unassigned 2,0 1.14.14.19 Pituitary ACTH Hypersecretion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1655322&form=6&db=m Ketoconazole and plasma and urine steroid levels in Cushing's disease. therapeutic application,unassigned 1,0 1.14.14.19 Pituitary ACTH Hypersecretion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3023421&form=6&db=m Use of ketoconazole in the treatment of Cushing's syndrome. causal interaction,therapeutic application,unassigned 1,1,0 1.14.14.19 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7479852&form=6&db=m Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome. ongoing research,unassigned 1,0 1.14.14.19 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8381802&form=6&db=m Ovarian steroidogenic responses to gonadotropin-releasing hormone agonist testing with nafarelin in hirsute women with adrenal responses to adrenocorticotropin suggestive of 3 beta-hydroxy-delta 5-steroid dehydrogenase deficiency. causal interaction,diagnostic usage,unassigned 4,2,0 1.14.14.19 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9194638&form=6&db=m 17-Hydroxyprogesterone responses to gonadotrophin-releasing hormone agonist buserelin and adrenocorticotrophin in polycystic ovary syndrome: investigation of adrenal and ovarian cytochrome P450c17alpha dysregulation. causal interaction,therapeutic application,unassigned 2,1,0 1.14.14.19 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10037253&form=6&db=m The treatment of insulin resistance does not improve adrenal cytochrome P450c17alpha enzyme dysregulation in polycystic ovary syndrome. therapeutic application,unassigned 4,0 1.14.14.19 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10360913&form=6&db=m Alternate pathway 17,20-lyase enzyme activity in the adrenals is enhanced in patients with polycystic ovary syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 1.14.14.19 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10852468&form=6&db=m Differential activity of the cytochrome P450 17alpha-hydroxylase and steroidogenic acute regulatory protein gene promoters in normal and polycystic ovary syndrome theca cells. diagnostic usage,ongoing research,unassigned 2,3,0 1.14.14.19 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12020974&form=6&db=m Genetic modelling of the estrogen metabolism as a risk factor of hormone-dependent disorders. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 1.14.14.19 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14684846&form=6&db=m Increased cytochrome P450 17alpha-hydroxylase promoter function in theca cells isolated from patients with polycystic ovary syndrome involves nuclear factor-1. causal interaction,ongoing research,unassigned 2,2,0 1.14.14.19 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15598676&form=6&db=m Dysregulation of cytochrome P450 17alpha-hydroxylase messenger ribonucleic acid stability in theca cells isolated from women with polycystic ovary syndrome. ongoing research,therapeutic application,unassigned 3,1,0 1.14.14.19 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18645707&form=6&db=m Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases. causal interaction,diagnostic usage,unassigned 3,4,0 1.14.14.19 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26096606&form=6&db=m No association between CYP17 -34T/C polymorphism and insulin resistance in Thai polycystic ovary syndrome. diagnostic usage,ongoing research,unassigned 1,2,0 1.14.14.19 Primary Ovarian Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18645707&form=6&db=m Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases. causal interaction,diagnostic usage,unassigned 3,4,0 1.14.14.19 Prostatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11262078&form=6&db=m A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. causal interaction,therapeutic application,unassigned 4,4,0 1.14.14.19 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7534917&form=6&db=m Inhibition of androgen synthesis by 22-hydroximino-23,24-bisnor-4-cholen-3-one. diagnostic usage,ongoing research,unassigned 2,4,0 1.14.14.19 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18495332&form=6&db=m Shorter CAG repeats in androgen receptor and non-GG genotypes in prostate-specific antigen loci are associated with decreased risk of benign prostatic hyperplasia and prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1606043&form=6&db=m 4-pregnene-3-one-20 beta-carboxaldehyde: a potent inhibitor of 17 alpha-hydroxylase/C17,20-lyase and of 5 alpha-reductase. therapeutic application,unassigned 1,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7539071&form=6&db=m Pyridyl substituted benzocycloalkenes: new inhibitors of 17 alpha-hydroxylase/17,20-lyase (P450 17 alpha). diagnostic usage,unassigned 3,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9113066&form=6&db=m Homology modelling of the enzyme P450 17 alpha-hydroxylase/17,20-lyase--a target for prostate cancer chemotherapy--from the crystal structure of P450BM-3. diagnostic usage,therapeutic application,unassigned 1,1,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10385215&form=6&db=m Inhibition of aromatase (P450Arom) by some 1-(benzofuran-2-ylmethyl)imidazoles. causal interaction,therapeutic application,unassigned 2,4,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10530940&form=6&db=m Imidazole substituted biphenyls: a new class of highly potent and in vivo active inhibitors of P450 17 as potential therapeutics for treatment of prostate cancer. causal interaction,therapeutic application,unassigned 3,4,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11668516&form=6&db=m Linkage and association of CYP17 gene in hereditary and sporadic prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12112031&form=6&db=m Inhibition of CYP 17, a new strategy for the treatment of prostate cancer. causal interaction,therapeutic application,unassigned 4,4,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12582021&form=6&db=m Association of the CYP17 gene polymorphism with the risk of prostate cancer: a meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15202489&form=6&db=m Synthesis of hydroxy derivatives of highly potent non-steroidal CYP 17 inhibitors as potential metabolites and evaluation of their activity by a non cellular assay using recombinant human enzyme. causal interaction,therapeutic application,unassigned 4,4,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16022662&form=6&db=m Inhibition of p450 17 as a new strategy for the treatment of prostate cancer. causal interaction,therapeutic application,unassigned 4,4,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16374734&form=6&db=m Abiraterone. Cougar Biotechnology. causal interaction,therapeutic application,unassigned 3,4,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17826473&form=6&db=m Association of a CYP17 polymorphism with overall survival in Caucasian patients with androgen-independent prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18672868&form=6&db=m Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer. causal interaction,therapeutic application,unassigned 3,4,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21978946&form=6&db=m Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer. causal interaction,therapeutic application,unassigned 3,4,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22222232&form=6&db=m Human steroid biosynthesis for the oncologist. causal interaction,therapeutic application,unassigned 1,4,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22258370&form=6&db=m [Inhibitors of androgen and estrogen biosynthesis in castration-resistant prostate cancer]. causal interaction,therapeutic application,unassigned 1,4,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22940515&form=6&db=m Oncology update. ongoing research,therapeutic application,unassigned 1,3,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23371447&form=6&db=m Targeting the Adrenal Gland in Castration-Resistant Prostate Cancer: A Case for Orteronel, a Selective CYP-17 17,20-Lyase Inhibitor. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,4,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24338986&form=6&db=m Comparison of abiraterone acetate versus ketoconazole in patients with metastatic castration resistant prostate cancer refractory to docetaxel. causal interaction,therapeutic application,unassigned 2,4,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24418642&form=6&db=m Phase I/II Trial of Orteronel (TAK-700)--an Investigational 17,20-Lyase Inhibitor--in Patients with Metastatic Castration-Resistant Prostate Cancer. diagnostic usage,therapeutic application,unassigned 1,2,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25264242&form=6&db=m Assessment of cytochrome P450-mediated drug-drug interaction potential of orteronel and exposure changes in patients with renal impairment using physiologically based pharmacokinetic modeling and simulation. causal interaction,therapeutic application,unassigned 3,4,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25556680&form=6&db=m Phase 1/2 study of orteronel (TAK-700), an investigational 17,20-lyase inhibitor, with docetaxel-prednisone in metastatic castration-resistant prostate cancer. ongoing research,therapeutic application,unassigned 1,3,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25701170&form=6&db=m Orteronel plus prednisone in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (ELM-PC 4): a double-blind, multicentre, phase 3, randomised, placebo-controlled trial. causal interaction,therapeutic application,unassigned 4,4,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25907623&form=6&db=m Commentary on "Comparison of abiraterone acetate versus ketoconazole in patients with metastatic castration resistant prostate cancer refractory to docetaxel." Peer A, Gottfried M, Sinibaldi V, Carducci MA, Eisenberger MA, Sella A, Leibowitz-Amit R, Berger R, Keizman D, Department of Oncology, Rambam Medical Center, Haifa, Israel.: Prostate 2014 Apr;74(4):433-40; doi:10.1002/pros.22765. [Epub 2013 Dec 11]. causal interaction,therapeutic application,unassigned 2,4,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26418412&form=6&db=m Pharmacokinetics and Urinary Excretion Mechanism of Orteronel (TAK-700), A Novel 17,20-Lyase Inhibitor, in Animals. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28373265&form=6&db=m Structural and Functional Evaluation of Clinically-Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1 (CYP17A1). therapeutic application,unassigned 1,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30012563&form=6&db=m Phase I Study of Seviteronel, a Selective CYP17 Lyase and Androgen Receptor Inhibitor, in Men with Castration-Resistant Prostate Cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31367790&form=6&db=m A population pharmacokinetic analysis of the oral CYP17 lyase and androgen receptor inhibitor seviteronel in patients with advanced/metastatic castration-resistant prostate cancer or breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2 1.14.14.19 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32327394&form=6&db=m Phase 2 Study of Seviteronel (INO-464) in Patients With Metastatic Castration-Resistant Prostate Cancer After Enzalutamide Treatment. therapeutic application,unassigned 3,0 1.14.14.19 Puberty, Delayed http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15866602&form=6&db=m Isolated 17,20-lyase (desmolase) deficiency in a 46,XX female presenting with delayed puberty. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.14.14.19 Puberty, Delayed http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25719302&form=6&db=m 17?-Hydroylase/17,20-lyase deficiency related to P.Y27*(c.81C>A) mutation in CYP17A1 gene. diagnostic usage,unassigned 4,0 1.14.14.19 Sexual Infantilism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20960109&form=6&db=m Male pseudohermaphroditism as a cause of secondary hypertension: a case report. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 1.14.14.19 Sexual Infantilism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24485502&form=6&db=m Fertility in patients with genetic deficiencies of cytochrome P450c17 (CYP17A1): combined 17-hydroxylase/17,20-lyase deficiency and isolated 17,20-lyase deficiency. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 1.14.14.19 Sexual Infantilism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26862015&form=6&db=m Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic. causal interaction,unassigned 4,0 1.14.14.19 Sexual Infantilism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34483146&form=6&db=m Identification of a homozygous c.1039C>T (p.R347C) variant in CYP17A1 in a 67-year-old female patient with partial 17?-hydroxylase/17,20-lyase deficiency. unassigned - 1.14.14.19 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22295121&form=6&db=m Role of AMP-activated protein kinase on steroid hormone biosynthesis in adrenal NCI-H295R cells. causal interaction,ongoing research,unassigned 1,2,0 1.14.14.19 steroid 11beta-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29858860&form=6&db=m Two rare forms of congenital adrenal hyperplasia, 11? hydroxylase deficiency and 17-hydroxylase/17,20-lyase deficiency, presenting with novel mutations. causal interaction,unassigned 4,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1515452&form=6&db=m Molecular basis of apparent isolated 17,20-lyase deficiency: compound heterozygous mutations in the C-terminal region (Arg(496)----Cys, Gln(461)----Stop) actually cause combined 17 alpha-hydroxylase/17,20-lyase deficiency. causal interaction,therapeutic application,unassigned 4,1,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2166072&form=6&db=m A case of male pseudohermaphroditism due to 17 alpha-hydroxylase deficiency and hormonal profiles in the nuclear family. causal interaction,diagnostic usage,unassigned 3,3,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2843762&form=6&db=m Structural characterization of normal and mutant human steroid 17 alpha-hydroxylase genes: molecular basis of one example of combined 17 alpha-hydroxylase/17,20 lyase deficiency. causal interaction,unassigned 3,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7626447&form=6&db=m 17 alpha-Hydroxylase/17,20-lyase defects. causal interaction,unassigned 4,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8396144&form=6&db=m Expression and purification of functional human 17 alpha-hydroxylase/17,20-lyase (P450c17) in Escherichia coli. Use of this system for study of a novel form of combined 17 alpha-hydroxylase/17,20-lyase deficiency. causal interaction,unassigned 1,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8481334&form=6&db=m Diagnosis and treatment of 17-hydroxylase deficiency. causal interaction,unassigned 4,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8943512&form=6&db=m Ovarian hyperstimulation syndrome with low oestradiol in non-classical 17 alpha-hydroxylase, 17,20-lyase deficiency: what is the role of oestrogens? causal interaction,unassigned 4,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9112555&form=6&db=m Defects of the testosterone biosynthetic pathway in boys with hypospadias. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9259306&form=6&db=m Steroid 17alpha-hydroxylase deficiency: first Australian case report. causal interaction,therapeutic application,unassigned 4,1,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9326943&form=6&db=m The genetic and functional basis of isolated 17,20-lyase deficiency. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9360545&form=6&db=m A single amino acid substitution in the putative redox partner-binding site of P450c17 as cause of isolated 17,20-lyase deficiency. causal interaction,unassigned 4,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9364364&form=6&db=m Subnormal cortisol response to adrenocorticotropin in isolated partial 17,20-lyase deficiency. causal interaction,therapeutic application,unassigned 4,1,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10720067&form=6&db=m 17alpha-hydroxylase/17,20-lyase deficiency as a model to study enzymatic activity regulation: role of phosphorylation. causal interaction,unassigned 4,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11549685&form=6&db=m Pitfalls in characterizing P450c17 mutations associated with isolated 17,20-lyase deficiency. causal interaction,therapeutic application,unassigned 4,1,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12466376&form=6&db=m Differential inhibition of 17alpha-hydroxylase and 17,20-lyase activities by three novel missense CYP17 mutations identified in patients with P450c17 deficiency. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12530647&form=6&db=m Towards a unifying mechanism for CYP17 mutations that cause isolated 17,20-lyase deficiency. causal interaction,unassigned 4,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14504283&form=6&db=m CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding. causal interaction,unassigned 3,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14625002&form=6&db=m Apparent pregnene hydroxylation deficiency (APHD): seeking the parentage of an orphan metabolome. causal interaction,unassigned 4,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15713706&form=6&db=m Subtle 17alpha-hydroxylase/17,20-lyase deficiency with homozygous Y201N mutation in an infertile woman. causal interaction,diagnostic usage,unassigned 4,2,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15866602&form=6&db=m Isolated 17,20-lyase (desmolase) deficiency in a 46,XX female presenting with delayed puberty. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18299473&form=6&db=m Metabolic evidence for impaired 17alpha-hydroxylase activity in a kindred bearing the E305G mutation for isolate 17,20-lyase activity. causal interaction,therapeutic application,unassigned 3,1,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18559916&form=6&db=m Homozygous mutation G539R in the gene for P450 oxidoreductase in a family previously diagnosed as having 17,20-lyase deficiency. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18996963&form=6&db=m Puberty in a case with novel 17-hydroxylase mutation and the putative role of estrogen in development of pubic hair. causal interaction,unassigned 4,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19454579&form=6&db=m Steroid 17alpha-hydroxylase deficiency: functional characterization of four mutations (A174E, V178D, R440C, L465P) in the CYP17A1 gene. causal interaction,unassigned 4,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20080843&form=6&db=m Isolated 17,20-lyase deficiency due to the cytochrome b5 mutation W27X. causal interaction,unassigned 4,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21340157&form=6&db=m Six new cases confirm the clinical molecular profile of complete combined 17?-hydroxylase/ 17,20-lyase deficiency in Brazil. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,1,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22217842&form=6&db=m Molecular basis of 17?-hydroxylase/17,20-lyase deficiency. causal interaction,unassigned 4,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24140098&form=6&db=m A review of the literature on common CYP17A1 mutations in adults with 17-hydroxylase/17,20-lyase deficiency, a case series of such mutations among Koreans and functional characteristics of a novel mutation. causal interaction,unassigned 4,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24485502&form=6&db=m Fertility in patients with genetic deficiencies of cytochrome P450c17 (CYP17A1): combined 17-hydroxylase/17,20-lyase deficiency and isolated 17,20-lyase deficiency. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26543560&form=6&db=m 17-hydroxylase/17,20-lyase deficiency due to a R96Q mutation causing hypertension and poor breast development. causal interaction,unassigned 4,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26862015&form=6&db=m Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic. causal interaction,unassigned 4,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26974035&form=6&db=m Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells. causal interaction,therapeutic application,unassigned 2,1,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28008861&form=6&db=m DELAYED DIAGNOSIS OF A 17-HYDROXYLASE/17,20-LYASE DEFICIENT CASE PRESENTED WITH 46,XY FEMALE: LOW NORMAL POTASSIUM CAN ALERT CLINICIAN. causal interaction,diagnostic usage,unassigned 4,2,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29595516&form=6&db=m A rare cause of congenital adrenal hyperplasia: Clinical and genetic findings and follow-up characteristics of six patients with 17- hydroxylase deficiency and two novel mutations. causal interaction,unassigned 3,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29858860&form=6&db=m Two rare forms of congenital adrenal hyperplasia, 11? hydroxylase deficiency and 17-hydroxylase/17,20-lyase deficiency, presenting with novel mutations. causal interaction,unassigned 4,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29880708&form=6&db=m MECHANISMS IN ENDOCRINOLOGY: Rare defects in adrenal steroidogenesis. causal interaction,unassigned 4,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30695673&form=6&db=m Two novel heterozygous mutations in the CYP17A1 gene in a Chinese patient with 17?-hydroxylase 17,20-lyase deficiency. causal interaction,unassigned 3,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31508570&form=6&db=m A novel mutation in CYP17A1 gene leads to congenital adrenal hyperplasia: A case report. causal interaction,diagnostic usage,unassigned 4,1,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31691616&form=6&db=m A rare enzymatic defect, true isolated 17,20-lyase deficiency leading to endocrine disorders and infertility: case report. causal interaction,therapeutic application,unassigned 4,1,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32051920&form=6&db=m Isolated 17,20-Lyase Deficiency in a CYB5A Mutated Female With Normal Sexual Development and Fertility. causal interaction,therapeutic application,unassigned 4,1,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32215889&form=6&db=m Clinical, Molecular, Functional, and Structural Characterization of CYP17A1 Mutations in Brazilian Patients with 17-Hydroxylase Deficiency. diagnostic usage,unassigned 1,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32820515&form=6&db=m [Clinical and genetic analysis of a patient with 17-hydroxylase/17,20-lyase deficiency]. causal interaction,diagnostic usage,unassigned 4,3,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33824988&form=6&db=m Successful Delivery in 17,20-Lyase Deficiency. causal interaction,unassigned 4,0 1.14.14.19 steroid 17alpha-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34290232&form=6&db=m A single-amino-acid in-frame deletion in CYP17A1 results in combined 17-hydroxylase and 17,20-lyase deficiency in an Iranian family despite the protein mutation site. unassigned - 1.14.14.19 steroid 21-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22951291&form=6&db=m The activities of 5?-reductase and 17,20-lyase determine the direction through androgen synthesis pathways in patients with 21-hydroxylase deficiency. causal interaction,unassigned 4,0 1.14.14.19 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33312738&form=6&db=m New frontiers on the molecular underpinnings of hypospadias according to severity. diagnostic usage,unassigned 1,0