1.14.14.17 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18728668&form=6&db=m Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease. diagnostic usage,ongoing research,unassigned 4,2,0 1.14.14.17 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26777065&form=6&db=m Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer. diagnostic usage,unassigned 3,0 1.14.14.17 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29765154&form=6&db=m The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation. unassigned - 1.14.14.17 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33664822&form=6&db=m Squalene epoxidase expression is associated with breast tumor progression and with a poor prognosis in breast cancer. causal interaction,diagnostic usage,unassigned 4,3,0 1.14.14.17 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25787749&form=6&db=m Squalene epoxidase (SQLE) promotes the growth and migration of the hepatocellular carcinoma cells. causal interaction,diagnostic usage,unassigned 1,3,0 1.14.14.17 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30734525&form=6&db=m Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal-regulated kinase signaling. causal interaction,ongoing research,unassigned 4,4,0 1.14.14.17 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34163246&form=6&db=m High SQLE Expression and Gene Amplification Correlates with Poor Prognosis in Head and Neck Squamous Cell Carcinoma. diagnostic usage,ongoing research,unassigned 4,1,0 1.14.14.17 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1964954&form=6&db=m Regulation of squalene epoxidase in HepG2 cells. ongoing research,unassigned 4,0 1.14.14.17 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15581604&form=6&db=m Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro. unassigned - 1.14.14.17 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15680919&form=6&db=m Supernatant protein factor requires phosphorylation and interaction with Golgi to stimulate cholesterol synthesis in hepatoma cells. causal interaction,unassigned 1,0 1.14.14.17 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25787749&form=6&db=m Squalene epoxidase (SQLE) promotes the growth and migration of the hepatocellular carcinoma cells. causal interaction,diagnostic usage,unassigned 1,3,0 1.14.14.17 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29669855&form=6&db=m Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,2,0 1.14.14.17 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32216563&form=6&db=m High Squalene Epoxidase in Tumors Predicts Worse Survival in Patients With Hepatocellular Carcinoma: Integrated Bioinformatic Analysis on NAFLD and HCC. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.14.14.17 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30734525&form=6&db=m Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal-regulated kinase signaling. causal interaction,ongoing research,unassigned 4,4,0 1.14.14.17 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34163246&form=6&db=m High SQLE Expression and Gene Amplification Correlates with Poor Prognosis in Head and Neck Squamous Cell Carcinoma. diagnostic usage,ongoing research,unassigned 4,1,0 1.14.14.17 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17981471&form=6&db=m Heteroallyl-containing 5-nitrofuranes as new anti-Trypanosoma cruzi agents with a dual mechanism of action. therapeutic application,unassigned 4,0 1.14.14.17 Cholelithiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14684588&form=6&db=m Cholesterol synthesis inhibition distal to squalene upregulates biliary phospholipid secretion and counteracts cholelithiasis in the genetically prone C57L/J mouse. ongoing research,therapeutic application,unassigned 3,3,0 1.14.14.17 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27358048&form=6&db=m Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia. ongoing research,therapeutic application,unassigned 2,1,0 1.14.14.17 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31072053&form=6&db=m Squalene Epoxidase Correlates E-Cadherin Expression and Overall Survival in Colorectal Cancer Patients: The Impact on Prognosis and Correlation to Clinicopathologic Features diagnostic usage,unassigned 4,0 1.14.14.17 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32946903&form=6&db=m Reduction of squalene epoxidase by cholesterol accumulation accelerates colorectal cancer progression and metastasis. unassigned - 1.14.14.17 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34268906&form=6&db=m Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling. unassigned - 1.14.14.17 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1700139&form=6&db=m Tellurium-induced neuropathy: a model for reversible reductions in myelin protein gene expression. therapeutic application,unassigned 1,0 1.14.14.17 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1721994&form=6&db=m Primary demyelination induced by exposure to tellurium alters mRNA levels for nerve growth factor receptor, SCIP, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteolipid protein in rat sciatic nerve. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,2 1.14.14.17 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1940906&form=6&db=m Tellurium-induced alterations in 3-hydroxy-3-methylglutaryl-CoA reductase gene expression and enzyme activity: differential effects in sciatic nerve and liver suggest tissue-specific regulation of cholesterol synthesis. causal interaction,therapeutic application,unassigned 4,1,0 1.14.14.17 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9804288&form=6&db=m Role of organotellurium species in tellurium neuropathy. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 1.14.14.17 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11181753&form=6&db=m Inhibition of human squalene monooxygenase by tellurium compounds: evidence of interaction with vicinal sulfhydryls. unassigned - 1.14.14.17 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12467639&form=6&db=m Squalene epoxidase as hypocholesterolemic drug target revisited. causal interaction,therapeutic application,unassigned 3,3,0 1.14.14.17 Dermatomycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26063944&form=6&db=m In Silico Analog Design for Terbinafine Against Trichophyton rubrum: A Preliminary Study. causal interaction,unassigned 4,0 1.14.14.17 Dermatomycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34159149&form=6&db=m Potential anti-alopecia constituents from Theobroma cacao: An in silico study. unassigned - 1.14.14.17 Gallstones http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14684588&form=6&db=m Cholesterol synthesis inhibition distal to squalene upregulates biliary phospholipid secretion and counteracts cholelithiasis in the genetically prone C57L/J mouse. ongoing research,therapeutic application,unassigned 3,3,0 1.14.14.17 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1649182&form=6&db=m Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells. causal interaction,therapeutic application,unassigned 4,4,0 1.14.14.17 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21991943&form=6&db=m Squalene monooxygenase - a target for hypercholesterolemic therapy. causal interaction,therapeutic application,unassigned 1,4,0 1.14.14.17 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22050222&form=6&db=m Squalene monooxygenase - a target for hypercholesterolemic therapy. causal interaction,therapeutic application,unassigned 4,4,0 1.14.14.17 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19309460&form=6&db=m Identification of the Arabidopsis dry2/sqe1-5 mutant reveals a central role for sterols in drought tolerance and regulation of reactive oxygen species. causal interaction,therapeutic application,unassigned 3,1,0 1.14.14.17 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24119181&form=6&db=m Squalene epoxidase as a target for manipulation of squalene levels in the yeast Saccharomyces cerevisiae. causal interaction,unassigned 2,0 1.14.14.17 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34058736&form=6&db=m The Emerging Terbinafine-Resistant Trichophyton Epidemic: What Is the Role of Antifungal Susceptibility Testing? causal interaction,therapeutic application,unassigned 4,2,0 1.14.14.17 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30760928&form=6&db=m Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. diagnostic usage,ongoing research,unassigned 3,3,0 1.14.14.17 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33067202&form=6&db=m Chemical Pathology of Homocysteine VIII. Effects of Tocotrienol, Geranylgeraniol, and Squalene on Thioretinaco Ozonide, Mitochondrial Permeability, and Oxidative Phosphorylation in Arteriosclerosis, Cancer, Neurodegeneration and Aging. causal interaction,ongoing research,unassigned 1,4,0 1.14.14.17 Lymphoma, Large-Cell, Anaplastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30760928&form=6&db=m Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. diagnostic usage,ongoing research,unassigned 3,3,0 1.14.14.17 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9300786&form=6&db=m Inhibition of cholesterol biosynthesis by squalene epoxidase inhibitor avoids apoptotic cell death in L6 myoblasts. causal interaction,therapeutic application,unassigned 1,3,0 1.14.14.17 Mycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12956204&form=6&db=m The efficacy and safety of terbinafine in children. diagnostic usage,therapeutic application,unassigned 3,1,0 1.14.14.17 Mycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17531123&form=6&db=m Genome-wide expression profiling of the response to terbinafine in Candida albicans using a cDNA microarray analysis. causal interaction,therapeutic application,unassigned 3,3,0 1.14.14.17 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30734525&form=6&db=m Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal-regulated kinase signaling. causal interaction,ongoing research,unassigned 4,4,0 1.14.14.17 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32946903&form=6&db=m Reduction of squalene epoxidase by cholesterol accumulation accelerates colorectal cancer progression and metastasis. unassigned - 1.14.14.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26767013&form=6&db=m Expression and significance of squalene epoxidase in squamous lung cancerous tissues and pericarcinoma tissues. causal interaction,unassigned 4,0 1.14.14.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27325648&form=6&db=m Cholesterol Metabolism and Prostate Cancer Lethality. diagnostic usage,unassigned 2,0 1.14.14.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29596888&form=6&db=m Squalene epoxidase as a promising metabolic target in cancer treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 1.14.14.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30760928&form=6&db=m Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. diagnostic usage,ongoing research,unassigned 3,3,0 1.14.14.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30792392&form=6&db=m The shape of human squalene epoxidase expands the arsenal against cancer. ongoing research,therapeutic application,unassigned 2,1,0 1.14.14.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32216563&form=6&db=m High Squalene Epoxidase in Tumors Predicts Worse Survival in Patients With Hepatocellular Carcinoma: Integrated Bioinformatic Analysis on NAFLD and HCC. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.14.14.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32711099&form=6&db=m Sterol synthesis pathway inhibition as a target for cancer treatment. therapeutic application,unassigned 2,0 1.14.14.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33067202&form=6&db=m Chemical Pathology of Homocysteine VIII. Effects of Tocotrienol, Geranylgeraniol, and Squalene on Thioretinaco Ozonide, Mitochondrial Permeability, and Oxidative Phosphorylation in Arteriosclerosis, Cancer, Neurodegeneration and Aging. causal interaction,ongoing research,unassigned 1,4,0 1.14.14.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33933449&form=6&db=m The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form. unassigned - 1.14.14.17 Neuroendocrine Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30626880&form=6&db=m A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition. unassigned - 1.14.14.17 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32216563&form=6&db=m High Squalene Epoxidase in Tumors Predicts Worse Survival in Patients With Hepatocellular Carcinoma: Integrated Bioinformatic Analysis on NAFLD and HCC. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.14.14.17 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33647280&form=6&db=m Squalene Epoxidase Induces Nonalcoholic Steatohepatitis Via Binding to Carbonic Anhydrase III and is a Therapeutic Target. therapeutic application,unassigned 3,0 1.14.14.17 Onychomycosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34297623&form=6&db=m Drug Sensitivity Profile of Fungi Isolated from Onychomycosis Patients and Evaluation of Squalene Epoxidase Mutation in One Terbinafine-Resistant Trichophyton mentagrophytes Species. ongoing research,therapeutic application,unassigned 1,2,0 1.14.14.17 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28595267&form=6&db=m Cholesterol uptake and regulation in high-grade and lethal prostate cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,1,0 1.14.14.17 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33986254&form=6&db=m Targeting epigenetic modulation of cholesterol synthesis as a therapeutic strategy for head and neck squamous cell carcinoma. causal interaction,therapeutic application,unassigned 2,2,0 1.14.14.17 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34163246&form=6&db=m High SQLE Expression and Gene Amplification Correlates with Poor Prognosis in Head and Neck Squamous Cell Carcinoma. diagnostic usage,ongoing research,unassigned 4,1,0 1.14.14.17 Tinea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34097482&form=6&db=m Checkerboard Analysis To Evaluate Synergistic Combinations of Existing Antifungal Drugs and Propylene Glycol Monocaprylate in Isolates from Recalcitrant Tinea Corporis and Cruris Patients Harboring Squalene Epoxidase Gene Mutation. ongoing research,unassigned 2,0 1.14.14.17 Tinea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34459941&form=6&db=m [Terbinafine-resistant dermatophytoses and onychomycosis due to Trichophyton rubrum]. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 1.14.14.17 Tooth Wear http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33786928&form=6&db=m Proteomic profile of the acquired enamel pellicle of professional wine tasters with erosive tooth wear. causal interaction,diagnostic usage,unassigned 1,1,0