1.13.11.11 Abortion, Habitual http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26511909&form=6&db=m Role of Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase in Patients with Recurrent Miscarriage. causal interaction,ongoing research,unassigned 1,1,0 1.13.11.11 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29901571&form=6&db=m Indoleamine-2,3-Dioxygenase in Non-Small Cell Lung Cancer: A Targetable Mechanism of Immune Resistance Frequently Coexpressed With PD-L1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 1.13.11.11 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30448912&form=6&db=m Assessment of TILs, IDO-1, and PD-L1 in resected non-small cell lung cancer: an immunohistochemical study with clinicopathological and prognostic implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 1.13.11.11 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30014971&form=6&db=m Indoleamine 2,3-dioxygenase 1 and programmed cell death-ligand 1 co-expression correlates with aggressive features in lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.13.11.11 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30448912&form=6&db=m Assessment of TILs, IDO-1, and PD-L1 in resected non-small cell lung cancer: an immunohistochemical study with clinicopathological and prognostic implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 1.13.11.11 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32853956&form=6&db=m B7-H4 and HHLA2, members of B7 family, are aberrantly expressed in EGFR mutated lung adenocarcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 1.13.11.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23630570&form=6&db=m Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's disease brain. ongoing research,unassigned 4,0 1.13.11.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28526475&form=6&db=m Identification and preliminary structure-activity relationships of 1-Indanone derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors. causal interaction,unassigned 3,0 1.13.11.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29475581&form=6&db=m Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. unassigned - 1.13.11.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32055299&form=6&db=m Recent advances in the discovery of indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33447045&form=6&db=m The Effect of Tryptophan 2,3-Dioxygenase Inhibition on Kynurenine Metabolism and Cognitive Function in the APP23 Mouse Model of Alzheimer's Disease. ongoing research,unassigned 2,0 1.13.11.11 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14577161&form=6&db=m [Activity of key enzymes of heme metabolism and cytochrome P-450 content in the rat liver in experimental rhabdomyolysis and hemolytic anemia] ongoing research,unassigned 2,0 1.13.11.11 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32055299&form=6&db=m Recent advances in the discovery of indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32924009&form=6&db=m B-Cell-Targeted 3DNA Nanotherapy Against Indoleamine 2,3-Dioxygenase 2 (IDO2) Ameliorates Autoimmune Arthritis in a Preclinical Model. therapeutic application,unassigned 1,0 1.13.11.11 Aspergillosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31134053&form=6&db=m Genetic Polymorphisms Affecting IDO1 or IDO2 Activity Differently Associate With Aspergillosis in Humans. diagnostic usage,unassigned 3,0 1.13.11.11 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27161289&form=6&db=m Tryptophan Metabolism in Allergic Disorders. causal interaction,therapeutic application,unassigned 4,1,0 1.13.11.11 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30623620&form=6&db=m Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,1,0 1.13.11.11 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31637003&form=6&db=m The proatherosclerotic function of indoleamine 2, 3-dioxygenase 1 in the developmental stage of atherosclerosis. diagnostic usage,ongoing research,unassigned 1,2,0 1.13.11.11 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32681019&form=6&db=m The proatherosclerotic function of indoleamine 2, 3-dioxygenase 1 in the developmental stage of atherosclerosis. diagnostic usage,ongoing research,unassigned 1,2,0 1.13.11.11 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22424783&form=6&db=m An epigenetic mechanism for high, synergistic expression of indoleamine 2,3-dioxygenase 1 (IDO1) by combined treatment with zebularine and IFN-?: potential therapeutic use in autoimmune diseases. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30797943&form=6&db=m Amino acid metabolism as drug target in autoimmune diseases. ongoing research,unassigned 2,0 1.13.11.11 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23144293&form=6&db=m The kynurenine pathway in brain tumor pathogenesis. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30134247&form=6&db=m TDO2 Overexpression Is Associated with Cancer Stem Cells and Poor Prognosis in Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,unassigned 1,3,0 1.13.11.11 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30143553&form=6&db=m A Role for Tryptophan-2,3-dioxygenase in CD8 T-cell Suppression and Evidence of Tryptophan Catabolism in Breast Cancer Patient Plasma. ongoing research,unassigned 2,0 1.13.11.11 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30481959&form=6&db=m Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway. ongoing research,therapeutic application,unassigned 1,1,0 1.13.11.11 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32107566&form=6&db=m Inhibition of IDO leads to IL-6-dependent systemic inflammation in mice when combined with photodynamic therapy. ongoing research,therapeutic application,unassigned 2,3,0 1.13.11.11 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32940463&form=6&db=m Liposomal Delivery of Mitoxantrone and a Cholesteryl Indoximod Prodrug Provides Effective Chemo-immunotherapy in Multiple Solid Tumors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0 1.13.11.11 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33166111&form=6&db=m Fighting Immune Cold and Reprogramming Immunosuppressive Tumor Microenvironment with Red Blood Cell Membrane-Camouflaged Nanobullets. unassigned - 1.13.11.11 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30659394&form=6&db=m Indoleamine Dioxygenase Inhibitors: Clinical Rationale and Current Development. causal interaction,therapeutic application,unassigned 1,2,0 1.13.11.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26965581&form=6&db=m Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0 1.13.11.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27440266&form=6&db=m Differential expression and significance of PD-L1, IDO-1 and B7-H4 in human lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 1.13.11.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29498788&form=6&db=m High IDO-1 Expression in Tumor Endothelial Cells is Associated with Response to Immunotherapy in Metastatic Renal Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.13.11.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30717285&form=6&db=m Indoleamine 2,3-dioxygenase 1 and Programmed Cell Death-ligand 1 Co-expression Predicts Poor Pathologic Response and Recurrence in Esophageal Squamous Cell Carcinoma after Neoadjuvant Chemoradiotherapy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 1.13.11.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30879760&form=6&db=m Subcutaneous inoculation position affects the immune environment in CT26 carcinomas. ongoing research,therapeutic application,unassigned 1,1,0 1.13.11.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31628024&form=6&db=m DNA methylation of indoleamine 2,3-dioxygenase 1 (IDO1) in head and neck squamous cell carcinomas correlates with IDO1 expression, HPV status, patients' survival, immune cell infiltrates, mutational load, and interferon ? signature. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.13.11.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32004580&form=6&db=m Changes in Indoleamine 2,3-Dioxygenase 1 Expression and CD8+ Tumor-Infiltrating Lymphocytes after Neoadjuvant Chemoradiation Therapy and Prognostic Significance in Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,2 1.13.11.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32125093&form=6&db=m Up-regulation of indoleamine 2,3-dioxygenase 1 (IDO1) expression and catalytic activity is associated with immunosuppression and poor prognosis in penile squamous cell carcinoma patients. causal interaction,diagnostic usage,unassigned 4,4,0 1.13.11.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32414944&form=6&db=m Prognostic impact of indoleamine 2,3-dioxygenase 1 (IDO1) mRNA expression on circulating tumour cells of patients with head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.13.11.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32683062&form=6&db=m Indoleamine 2,3-Dioxygenase-1 Expression in Adrenocortical Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4 1.13.11.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33410234&form=6&db=m Tryptophan 2,3-dioxygenase in tumor cells is associated with resistance to immunotherapy in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 1.13.11.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33738077&form=6&db=m Discovery of Imidazopyridines as Potent Inhibitors of Indoleamine 2,3-Dioxygenase 1 for Cancer Immunotherapy. causal interaction,therapeutic application,unassigned 4,4,0 1.13.11.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33828565&form=6&db=m Indoleamine 2,3-Dioxygenase 1 Inhibitor-Loaded Nanosheets Enhance CAR-T Cell Function in Esophageal Squamous Cell Carcinoma. ongoing research,unassigned 3,0 1.13.11.11 Carcinoma, Adenosquamous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29901571&form=6&db=m Indoleamine-2,3-Dioxygenase in Non-Small Cell Lung Cancer: A Targetable Mechanism of Immune Resistance Frequently Coexpressed With PD-L1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 1.13.11.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28625979&form=6&db=m Intestine-Specific Homeobox Gene ISX Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1 1.13.11.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30264546&form=6&db=m Mechanism and prognostic value of indoleamine 2,3-dioxygenase 1 expressed in hepatocellular carcinoma. diagnostic usage,unassigned 4,0 1.13.11.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31445192&form=6&db=m Novel conjugates with dual suppression of glutathione S-transferases and tryptophan-2,3-dioxygenase activities for improving hepatocellular carcinoma therapy. causal interaction,therapeutic application,unassigned 3,2,0 1.13.11.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31806639&form=6&db=m Tryptophan 2,3-Dioxygenase Expression Identified in Human Hepatocellular Carcinoma Cells and in Intratumoral Pericytes of Most Cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 1.13.11.11 Carcinoma, Medullary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26965581&form=6&db=m Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0 1.13.11.11 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27440266&form=6&db=m Differential expression and significance of PD-L1, IDO-1 and B7-H4 in human lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 1.13.11.11 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30448912&form=6&db=m Assessment of TILs, IDO-1, and PD-L1 in resected non-small cell lung cancer: an immunohistochemical study with clinicopathological and prognostic implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 1.13.11.11 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30671955&form=6&db=m Investigation of indolamine 2, 3 dioxygenase (IDO-1) gene expression by real-time PCR among patients with lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 1.13.11.11 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32536910&form=6&db=m Indoleamine 2,3-Dioxygenase 2 Immunohistochemical Expression in Resected Human Non-small Cell Lung Cancer: A Potential New Prognostic Tool. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 1.13.11.11 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29498788&form=6&db=m High IDO-1 Expression in Tumor Endothelial Cells is Associated with Response to Immunotherapy in Metastatic Renal Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.13.11.11 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33410234&form=6&db=m Tryptophan 2,3-dioxygenase in tumor cells is associated with resistance to immunotherapy in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 1.13.11.11 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33738077&form=6&db=m Discovery of Imidazopyridines as Potent Inhibitors of Indoleamine 2,3-Dioxygenase 1 for Cancer Immunotherapy. causal interaction,therapeutic application,unassigned 4,4,0 1.13.11.11 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31628024&form=6&db=m DNA methylation of indoleamine 2,3-dioxygenase 1 (IDO1) in head and neck squamous cell carcinomas correlates with IDO1 expression, HPV status, patients' survival, immune cell infiltrates, mutational load, and interferon ? signature. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.13.11.11 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32125093&form=6&db=m Up-regulation of indoleamine 2,3-dioxygenase 1 (IDO1) expression and catalytic activity is associated with immunosuppression and poor prognosis in penile squamous cell carcinoma patients. causal interaction,diagnostic usage,unassigned 4,4,0 1.13.11.11 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32414944&form=6&db=m Prognostic impact of indoleamine 2,3-dioxygenase 1 (IDO1) mRNA expression on circulating tumour cells of patients with head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.13.11.11 Carcinosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32085927&form=6&db=m Landscape of Immune Checkpoint Inhibition in Carcinosarcoma (MMMT): Analysis of IDO-1, PD-L1 and PD-1. diagnostic usage,ongoing research,unassigned 3,3,0 1.13.11.11 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34021461&form=6&db=m Indoleamine 2,3-Dioxygenase 1 (IDO1) Promotes Cardiac Hypertrophy via a PI3K-AKT-mTOR-Dependent Mechanism. diagnostic usage,unassigned 1,0 1.13.11.11 Cluster Headache http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32842609&form=6&db=m The Role of the Kynurenine Signaling Pathway in Different Chronic Pain Conditions and Potential Use of Therapeutic Agents. unassigned - 1.13.11.11 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20181893&form=6&db=m Induction of IDO-1 by immunostimulatory DNA limits severity of experimental colitis. unassigned - 1.13.11.11 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32055962&form=6&db=m Gut microorganisms and their metabolites modulate the severity of acute colitis in a tryptophan metabolism-dependent manner. causal interaction,unassigned 4,0 1.13.11.11 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22108515&form=6&db=m Clinicopathological significance of indoleamine 2,3-dioxygenase 1 expression in colorectal cancer. diagnostic usage,ongoing research,unassigned 4,3,0 1.13.11.11 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25881064&form=6&db=m Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers. unassigned - 1.13.11.11 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29607498&form=6&db=m 1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells. causal interaction,diagnostic usage,unassigned 3,2,0 1.13.11.11 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32328426&form=6&db=m Supramolecular Prodrug Nanovectors for Active Tumor Targeting and Combination Immunotherapy of Colorectal Cancer. ongoing research,therapeutic application,unassigned 1,1,0 1.13.11.11 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32563943&form=6&db=m Oxaliplatin-/NLG919 prodrugs-constructed liposomes for effective chemo-immunotherapy of colorectal cancer. causal interaction,diagnostic usage,unassigned 4,4,0 1.13.11.11 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33665222&form=6&db=m Inhibition of indoleamine 2,3-dioxygenase 1 synergizes with oxaliplatin for efficient colorectal cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 1.13.11.11 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34289794&form=6&db=m Tryptophan metabolites modulate inflammatory bowel disease and colorectal cancer by affecting immune system. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 1.13.11.11 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32914363&form=6&db=m Effects of Lactobacillus casei Strain T2 (IBRC-M10783) on the Modulation of Th17/Treg and Evaluation of miR-155, miR-25, and IDO-1 Expression in a Cuprizone-Induced C57BL/6 Mouse Model of Demyelination. ongoing research,unassigned 3,0 1.13.11.11 Dermatitis, Atopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30623620&form=6&db=m Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,1,0 1.13.11.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32067945&form=6&db=m Exogenous melatonin restrains neuroinflammation in high fat diet induced diabetic rats through attenuating indoleamine 2,3-dioxygenase 1 expression. unassigned - 1.13.11.11 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28450863&form=6&db=m The Proteasome Inhibitor Bortezomib Controls Indoleamine 2,3-Dioxygenase 1 Breakdown and Restores Immune Regulation in Autoimmune Diabetes. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 1.13.11.11 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29563329&form=6&db=m Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes. causal interaction,ongoing research,unassigned 1,1,0 1.13.11.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32067945&form=6&db=m Exogenous melatonin restrains neuroinflammation in high fat diet induced diabetic rats through attenuating indoleamine 2,3-dioxygenase 1 expression. unassigned - 1.13.11.11 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18665439&form=6&db=m Acyclovir inhibits rat liver tryptophan-2,3-dioxygenase and induces a concomitant rise in brain serotonin and 5-hydroxyindole acetic acid levels. diagnostic usage,ongoing research,unassigned 2,3,0 1.13.11.11 Encephalitis, Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18665439&form=6&db=m Acyclovir inhibits rat liver tryptophan-2,3-dioxygenase and induces a concomitant rise in brain serotonin and 5-hydroxyindole acetic acid levels. diagnostic usage,ongoing research,unassigned 2,3,0 1.13.11.11 Encephalitis, Viral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24530381&form=6&db=m Indoleamine 2,3-dioxygenase 1 is upregulated in activated microglia in mice cerebellum during acute viral encephalitis. causal interaction,ongoing research,unassigned 1,3,0 1.13.11.11 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24974860&form=6&db=m IL-1? Increases Expression of Tryptophan 2,3-dioxygenase and Stimulates Tryptophan Catabolism in Endometrioma Stromal Cells. ongoing research,unassigned 2,0 1.13.11.11 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29805749&form=6&db=m Indoleamine 2,3-dioxygenase 1 and overall survival of patients diagnosed with esophageal cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,3,0 1.13.11.11 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30717285&form=6&db=m Indoleamine 2,3-dioxygenase 1 and Programmed Cell Death-ligand 1 Co-expression Predicts Poor Pathologic Response and Recurrence in Esophageal Squamous Cell Carcinoma after Neoadjuvant Chemoradiotherapy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 1.13.11.11 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32004580&form=6&db=m Changes in Indoleamine 2,3-Dioxygenase 1 Expression and CD8+ Tumor-Infiltrating Lymphocytes after Neoadjuvant Chemoradiation Therapy and Prognostic Significance in Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,2 1.13.11.11 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33828565&form=6&db=m Indoleamine 2,3-Dioxygenase 1 Inhibitor-Loaded Nanosheets Enhance CAR-T Cell Function in Esophageal Squamous Cell Carcinoma. ongoing research,unassigned 3,0 1.13.11.11 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26651356&form=6&db=m Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 1.13.11.11 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31866995&form=6&db=m Hypoxia Inducible Factor 1? Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma. therapeutic application,unassigned 1,0 1.13.11.11 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32035622&form=6&db=m Indoleamine 2,3-dioxygenase 1 is highly expressed in glioma stem cells. causal interaction,unassigned 2,0 1.13.11.11 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22737628&form=6&db=m The aryl hydrocarbon receptor in tumor immunity. unassigned - 1.13.11.11 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23090118&form=6&db=m Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion. causal interaction,unassigned 3,0 1.13.11.11 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25054303&form=6&db=m Shaping the glioma immune microenvironment through tryptophan metabolism. causal interaction,unassigned 3,0 1.13.11.11 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25132599&form=6&db=m Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 1.13.11.11 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25415278&form=6&db=m Involvement of the kynurenine pathway in human glioma pathophysiology. causal interaction,ongoing research,unassigned 2,1,0 1.13.11.11 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26708701&form=6&db=m Tryptophan-2,3-dioxygenase is regulated by prostaglandin E2 in malignant glioma via a positive signaling loop involving prostaglandin E receptor-4. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1 1.13.11.11 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29667084&form=6&db=m Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors. diagnostic usage,ongoing research,unassigned 1,2,0 1.13.11.11 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32035622&form=6&db=m Indoleamine 2,3-dioxygenase 1 is highly expressed in glioma stem cells. causal interaction,unassigned 2,0 1.13.11.11 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32436060&form=6&db=m A phase 1 study of PF-06840003, an oral indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor in patients with recurrent malignant glioma. ongoing research,therapeutic application,unassigned 2,4,0 1.13.11.11 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32477324&form=6&db=m Constitutive Expression of the Immunosuppressive Tryptophan Dioxygenase TDO2 in Glioblastoma Is Driven by the Transcription Factor C/EBP?. causal interaction,therapeutic application,unassigned 4,1,0 1.13.11.11 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33870196&form=6&db=m Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells. causal interaction,therapeutic application,unassigned 3,2,0 1.13.11.11 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2300969&form=6&db=m Comparison of effects of nicotinic acid or tryptophan on tryptophan 2,3-dioxygenase in acute and chronic studies. causal interaction,therapeutic application,unassigned 3,1,0 1.13.11.11 Graft vs Host Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33649207&form=6&db=m IDO1 scavenges reactive oxygen species in myeloid-derived suppressor cells to prevent graft-versus-host disease. therapeutic application,unassigned 1,0 1.13.11.11 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31726186&form=6&db=m The autoimmune response elicited by mouse hepatitis virus (MHV-A59) infection is modulated by liver tryptophan-2,3-dioxygenase (TDO). causal interaction,ongoing research,unassigned 1,1,0 1.13.11.11 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32540487&form=6&db=m Liver tryptophan 2,3-dioxygenase in the mouse hepatitis virus (MHV-A59) model. ongoing research,unassigned 3,0 1.13.11.11 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34367262&form=6&db=m Genomic and Immunologic Correlates of Indoleamine 2,3-Dioxygenase Pathway Expression in Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 1.13.11.11 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26142400&form=6&db=m Indoleamine 2,3-dioxygenase 1 in corneal endothelial cells limits herpes simplex virus type 1-induced acquired immune response. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 1.13.11.11 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26181815&form=6&db=m Increased Tryptophan Catabolism is Associated with Increased Frequency of CD161+Tc17/MAIT Cells, and Lower CD4+ T cell Count in HIV-1 infected Patients on cART after Two Years of Follow-up. therapeutic application,unassigned 1,0 1.13.11.11 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26470032&form=6&db=m Increased Tryptophan Catabolism Is Associated With Increased Frequency of CD161+Tc17/MAIT Cells and Lower CD4+ T-Cell Count in HIV-1 Infected Patients on cART After 2 Years of Follow-Up. therapeutic application,unassigned 1,0 1.13.11.11 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28165296&form=6&db=m The activation of the kynurenine pathway in a rat model with renovascular hypertension. causal interaction,unassigned 3,0 1.13.11.11 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21765346&form=6&db=m Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3 1.13.11.11 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2085957&form=6&db=m Tryptophan 2,3-dioxygenase activity in turkey poults infected with Bordetella avium. unassigned - 1.13.11.11 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21791421&form=6&db=m Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44+ mucosal NK cells during SIV infection. causal interaction,unassigned 4,0 1.13.11.11 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22649518&form=6&db=m M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. causal interaction,ongoing research,unassigned 3,4,0 1.13.11.11 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25314246&form=6&db=m Loss of Th22 cells is associated with increased immune activation and IDO-1 activity in HIV-1 infection. causal interaction,unassigned 4,0 1.13.11.11 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26459907&form=6&db=m Benzo[b]quinolizinium Derivatives Have a Strong Antimalarial Activity and Inhibit Indoleamine Dioxygenase. causal interaction,unassigned 4,0 1.13.11.11 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27658027&form=6&db=m The High-Risk Human Papillomavirus E6 Oncogene Exacerbates the Negative Effect of Tryptophan Starvation on the Development of Chlamydia trachomatis. causal interaction,therapeutic application,unassigned 3,1,0 1.13.11.11 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31325428&form=6&db=m Epithelial Indoleamine 2,3-Dioxygenase 1 Modulates Aryl Hydrocarbon Receptor and Notch Signaling to Increase Differentiation of Secretory Cells and Alter Mucus-Associated Microbiota. causal interaction,unassigned 4,0 1.13.11.11 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31726186&form=6&db=m The autoimmune response elicited by mouse hepatitis virus (MHV-A59) infection is modulated by liver tryptophan-2,3-dioxygenase (TDO). causal interaction,ongoing research,unassigned 1,1,0 1.13.11.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26191458&form=6&db=m Attenuation of high sucrose diet-induced insulin resistance in tryptophan 2,3-dioxygenase deficient Drosophila melanogaster vermilion mutants. unassigned - 1.13.11.11 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32940463&form=6&db=m Liposomal Delivery of Mitoxantrone and a Cholesteryl Indoximod Prodrug Provides Effective Chemo-immunotherapy in Multiple Solid Tumors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0 1.13.11.11 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34116832&form=6&db=m Tryptophan catabolism is dysregulated in leiomyomas. diagnostic usage,ongoing research,unassigned 3,2,0 1.13.11.11 Leprosy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33040382&form=6&db=m Mycobacterium leprae induces a tolerogenic profile in monocyte-derived dendritic cells via TLR2 induction of IDO. causal interaction,unassigned 4,0 1.13.11.11 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24903009&form=6&db=m Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 1.13.11.11 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24903009&form=6&db=m Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 1.13.11.11 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29038460&form=6&db=m A novel immunohistochemical score to predict early mortality in acute myeloid leukemia patients based on indoleamine 2,3 dioxygenase expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 1.13.11.11 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28465467&form=6&db=m Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl4-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 1.13.11.11 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32771520&form=6&db=m Mutual antagonism between indoleamine 2,3-dioxygenase 1 and nuclear factor E2-related factor 2 regulates the maturation status of DCs in liver fibrosis. unassigned - 1.13.11.11 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33414436&form=6&db=m Indoleamine 2,3-dioxygenase 1 limits hepatic inflammatory cells recruitment and promotes bile duct ligation-induced liver fibrosis. ongoing research,unassigned 1,0 1.13.11.11 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33569476&form=6&db=m A narrative review of the roles of indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in liver diseases. unassigned - 1.13.11.11 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24099220&form=6&db=m Discovery of Tryptanthrin Derivatives as Potent Inhibitors of Indoleamine 2, 3-Dioxygenase with Therapeutic Activity in LLC tumor-bearing Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 1.13.11.11 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27440266&form=6&db=m Differential expression and significance of PD-L1, IDO-1 and B7-H4 in human lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 1.13.11.11 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29901571&form=6&db=m Indoleamine-2,3-Dioxygenase in Non-Small Cell Lung Cancer: A Targetable Mechanism of Immune Resistance Frequently Coexpressed With PD-L1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 1.13.11.11 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30194181&form=6&db=m Radiological Features of IDO1+/PDL1+ Lung Adenocarcinoma: A Retrospective Single-institution Study. therapeutic application,unassigned 4,0 1.13.11.11 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30367104&form=6&db=m Differential expression of PD-L1 and IDO1 in association with the immune microenvironment in resected lung adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,3,0 1.13.11.11 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30448912&form=6&db=m Assessment of TILs, IDO-1, and PD-L1 in resected non-small cell lung cancer: an immunohistochemical study with clinicopathological and prognostic implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 1.13.11.11 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30671955&form=6&db=m Investigation of indolamine 2, 3 dioxygenase (IDO-1) gene expression by real-time PCR among patients with lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 1.13.11.11 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32067413&form=6&db=m Class A CpG oligodeoxynucleotide inhibits IFN-?-induced signaling and apoptosis in lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 1.13.11.11 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32382333&form=6&db=m Gene silencing of indoleamine 2,3-dioxygenase 1 inhibits lung cancer growth by suppressing T-cell exhaustion. causal interaction,ongoing research,unassigned 1,3,0 1.13.11.11 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32536910&form=6&db=m Indoleamine 2,3-Dioxygenase 2 Immunohistochemical Expression in Resected Human Non-small Cell Lung Cancer: A Potential New Prognostic Tool. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 1.13.11.11 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32481253&form=6&db=m IDO, TDO, and AHR overexpression is associated with poor outcome in diffuse large B-cell lymphoma patients in the rituximab era. diagnostic usage,ongoing research,unassigned 2,3,0 1.13.11.11 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32481253&form=6&db=m IDO, TDO, and AHR overexpression is associated with poor outcome in diffuse large B-cell lymphoma patients in the rituximab era. diagnostic usage,ongoing research,unassigned 2,3,0 1.13.11.11 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23682557&form=6&db=m Up-regulated expression of indoleamine 2,3-dioxygenase 1 in non-Hodgkin lymphoma correlates with increased regulatory T-cell infiltration. causal interaction,diagnostic usage,unassigned 4,4,0 1.13.11.11 Lymphoma, T-Cell, Cutaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28405495&form=6&db=m Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas. diagnostic usage,ongoing research,unassigned 3,1,0 1.13.11.11 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18687401&form=6&db=m Purification and biochemical characterization of a recombinant Anopheles gambiae tryptophan 2,3-dioxygenase expressed in Escherichia coli. therapeutic application,unassigned 1,0 1.13.11.11 Malaria, Cerebral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26459907&form=6&db=m Benzo[b]quinolizinium Derivatives Have a Strong Antimalarial Activity and Inhibit Indoleamine Dioxygenase. causal interaction,unassigned 4,0 1.13.11.11 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23879623&form=6&db=m The expanding roles of 1-methyl-tryptophan (1-MT): in addition to inhibiting kynurenine production, 1-MT activates the synthesis of melatonin in skin cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 1.13.11.11 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27058624&form=6&db=m Gene silencing of indoleamine 2,3-dioxygenase 2 in melanoma cells induces apoptosis through the suppression of NAD+ and inhibits in vivo tumor growth. ongoing research,therapeutic application,unassigned 4,1,0 1.13.11.11 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30639792&form=6&db=m Investigation of indoleamine 2,3-dioxygenase 1 expression in uveal melanoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 1.13.11.11 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32050636&form=6&db=m Expression of Tryptophan 2,3-Dioxygenase in Metastatic Uveal Melanoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 1.13.11.11 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32382333&form=6&db=m Gene silencing of indoleamine 2,3-dioxygenase 1 inhibits lung cancer growth by suppressing T-cell exhaustion. causal interaction,ongoing research,unassigned 1,3,0 1.13.11.11 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33738077&form=6&db=m Discovery of Imidazopyridines as Potent Inhibitors of Indoleamine 2,3-Dioxygenase 1 for Cancer Immunotherapy. causal interaction,therapeutic application,unassigned 4,4,0 1.13.11.11 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23358471&form=6&db=m In vivo metabolism of tryptophan in meningiomas is mediated by indoleamine 2,3-dioxygenase 1. therapeutic application,unassigned 1,0 1.13.11.11 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26092774&form=6&db=m Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas. causal interaction,unassigned 1,0 1.13.11.11 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27473286&form=6&db=m Altered tryptophan metabolism in human meningioma. causal interaction,unassigned 1,0 1.13.11.11 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23232072&form=6&db=m Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with immune system abnormalities in multiple myeloma. unassigned - 1.13.11.11 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28117398&form=6&db=m Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis. causal interaction,unassigned 3,0 1.13.11.11 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33055013&form=6&db=m Polyamines and Kynurenines at the Intersection of Immune Modulation. ongoing research,unassigned 4,0 1.13.11.11 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28004656&form=6&db=m Co-delivery of indoleamine 2,3-dioxygenase prevents loss of expression of an antigenic transgene in dystrophic mouse muscles. ongoing research,unassigned 4,0 1.13.11.11 Mycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25256754&form=6&db=m Microbiota control of a tryptophan-AhR pathway in disease tolerance to fungi. unassigned - 1.13.11.11 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28689792&form=6&db=m Functional role of kynurenine and aryl hydrocarbon receptor axis in chronic rhinosinusitis with nasal polyps. causal interaction,ongoing research,unassigned 3,4,0 1.13.11.11 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23200064&form=6&db=m Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27578919&form=6&db=m Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer. diagnostic usage,unassigned 3,0 1.13.11.11 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28201999&form=6&db=m Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer. causal interaction,unassigned 3,0 1.13.11.11 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31703602&form=6&db=m Distinct tumor microenvironments of lytic and blastic bone metastases in prostate cancer patients. diagnostic usage,therapeutic application,unassigned 3,3,0 1.13.11.11 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33166111&form=6&db=m Fighting Immune Cold and Reprogramming Immunosuppressive Tumor Microenvironment with Red Blood Cell Membrane-Camouflaged Nanobullets. unassigned - 1.13.11.11 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34158230&form=6&db=m Immune checkpoints and liver resection after neoadjuvant chemotherapy including bevacizumab in patients with microsatellite-stable colorectal liver metastases. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 1.13.11.11 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34539663&form=6&db=m Targeting Indoleamine 2,3-Dioxygenase 1: Fighting Cancers via Dormancy Regulation. causal interaction,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3009001&form=6&db=m Heme enzyme patterns in genetically and chemically induced mouse liver tumors. ongoing research,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3802102&form=6&db=m Heme enzyme patterns in rat liver nodules and tumors. ongoing research,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9949305&form=6&db=m Serial transplants of DMBA-induced mammary tumors in Fischer rats as a model system for human breast cancer. VI. The role of different forms of tumor-associated stress for the regulation of pineal melatonin secretion. causal interaction,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10721063&form=6&db=m Melatonin in cancer patients and in tumor-bearing animals. therapeutic application,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14748880&form=6&db=m Immunoactivative role of indoleamine 2,3-dioxygenase in human hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21517752&form=6&db=m The interplay between indoleamine 2,3-dioxygenase 1 (IDO1) and cyclooxygenase (COX)-2 in chronic inflammation and cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21726069&form=6&db=m Tryptophan 2,3-Dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators. causal interaction,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21976023&form=6&db=m An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. ongoing research,unassigned 2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22112538&form=6&db=m Novel indoleamine 2,3-dioxygenase-1 inhibitors from a multistep in silico screen. causal interaction,unassigned 4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22616902&form=6&db=m Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22737628&form=6&db=m The aryl hydrocarbon receptor in tumor immunity. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23090116&form=6&db=m Systemic delivery of Salmonella typhimurium transformed with IDO shRNA enhances intratumoral vector colonization and suppresses tumor growth. ongoing research,therapeutic application,unassigned 2,2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23090118&form=6&db=m Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion. causal interaction,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23144293&form=6&db=m The kynurenine pathway in brain tumor pathogenesis. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23200064&form=6&db=m Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23314482&form=6&db=m Formation of an N-formylkynurenine-derived fluorophore and its use for measuring indoleamine 2,3-dioxygenase 1 activity. causal interaction,unassigned 4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23333332&form=6&db=m Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase reveals insights into substrate recognition and catalytic mechanism. therapeutic application,unassigned 2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23879623&form=6&db=m The expanding roles of 1-methyl-tryptophan (1-MT): in addition to inhibiting kynurenine production, 1-MT activates the synthesis of melatonin in skin cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24099220&form=6&db=m Discovery of Tryptanthrin Derivatives as Potent Inhibitors of Indoleamine 2, 3-Dioxygenase with Therapeutic Activity in LLC tumor-bearing Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24262887&form=6&db=m Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1). unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24269239&form=6&db=m Antitumour agents as inhibitors of tryptophan 2,3-dioxygenase. causal interaction,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24517146&form=6&db=m INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IS UPREGULATED IN THYROID CARCINOMA AND DRIVES THE DEVELOPMENT OF AN IMMUNOSUPPRESSANT TUMOR MICROENVIRONMENT. causal interaction,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24919418&form=6&db=m Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon ? gene transfer on interferon ?-mediated antitumor activity. causal interaction,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25036789&form=6&db=m Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. therapeutic application,unassigned 4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25132599&form=6&db=m Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25313323&form=6&db=m Crystal Structures and Structure-Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25415278&form=6&db=m Involvement of the kynurenine pathway in human glioma pathophysiology. causal interaction,ongoing research,unassigned 2,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25881064&form=6&db=m Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25949861&form=6&db=m Tryptophan 2,3-dioxygenase (TDO)-reactive T cells differ in their functional characteristics in health and cancer. diagnostic usage,ongoing research,unassigned 2,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25955018&form=6&db=m An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells. causal interaction,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26033215&form=6&db=m Inhibition of indoleamine 2,3-dioxygenase 1 expression alters immune response in colon tumor microenvironment in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26269528&form=6&db=m Tumoral Immune Resistance Mediated by Enzymes That Degrade Tryptophan. ongoing research,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26642377&form=6&db=m Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1. causal interaction,therapeutic application,unassigned 3,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26965581&form=6&db=m Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27058624&form=6&db=m Gene silencing of indoleamine 2,3-dioxygenase 2 in melanoma cells induces apoptosis through the suppression of NAD+ and inhibits in vivo tumor growth. ongoing research,therapeutic application,unassigned 4,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27151136&form=6&db=m Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma. diagnostic usage,ongoing research,unassigned 3,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27267006&form=6&db=m Nitrobenzofurazan derivatives of N'-hydroxyamidines as potent inhibitors of indoleamine-2,3-dioxygenase 1. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27440266&form=6&db=m Differential expression and significance of PD-L1, IDO-1 and B7-H4 in human lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27469130&form=6&db=m 1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2). causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27546049&form=6&db=m Docking Studies and Molecular Dynamic Simulations Reveal Different Features of IDO1 Structure. causal interaction,unassigned 2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27578919&form=6&db=m Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer. diagnostic usage,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27769672&form=6&db=m Discovery and preliminary structure-activity relationship of 1H-indazoles with promising indoleamine-2,3-dioxygenase 1 (IDO1) inhibition properties. causal interaction,therapeutic application,unassigned 3,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27891058&form=6&db=m IDO2: A Pathogenic Mediator of Inflammatory Autoimmunity. therapeutic application,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27990653&form=6&db=m Population Pharmacokinetic and Pharmacodynamic Modeling of Epacadostat in Patients With Advanced Solid Malignancies. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28011425&form=6&db=m Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions. causal interaction,diagnostic usage,unassigned 4,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28105265&form=6&db=m Targeting the Inhibition of Tryptophan 2,3-Dioxygenase (TDO-2) for Cancer Treatment. therapeutic application,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28123606&form=6&db=m Strong Correlation of Indoleamine 2,3-Dioxygenase 1 Expression with Basal-Like Phenotype and Increased Lymphocytic Infiltration in Triple-Negative Breast Cancer. causal interaction,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28201999&form=6&db=m Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer. causal interaction,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28264810&form=6&db=m Promoter Methylation Modulates Indoleamine 2,3-Dioxygenase 1 Induction by Activated T Cells in Human Breast Cancers. diagnostic usage,ongoing research,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28319781&form=6&db=m Systematic study of imidazoles inhibiting IDO1 via the integration of molecular mechanics and quantum mechanics calculations. diagnostic usage,therapeutic application,unassigned 1,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28526475&form=6&db=m Identification and preliminary structure-activity relationships of 1-Indanone derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors. causal interaction,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28585214&form=6&db=m The Interactions Between Kynurenine, Folate, Methionine and Pteridine Pathways in Obesity. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28667875&form=6&db=m Discovery of potent IDO1 inhibitors derived from tryptophan using scaffold-hopping and structure-based design approaches. causal interaction,therapeutic application,unassigned 1,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28697066&form=6&db=m Viral-induced Modulation of Multiple Checkpoint Proteins in Cancers. diagnostic usage,ongoing research,unassigned 1,2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28731684&form=6&db=m The Binding Mode of N-Hydroxyamidines to Indoleamine 2,3-Dioxygenase 1 (IDO1). therapeutic application,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28733349&form=6&db=m Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28735627&form=6&db=m Inhibition of indoleamine 2,3-dioxygenase activity by fatty acids and prostaglandins: A structure function analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28765120&form=6&db=m Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28768924&form=6&db=m A Novel High Throughput Virtual Screening Protocol to Discover New Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors. therapeutic application,unassigned 4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28850241&form=6&db=m Lymphoma Immunochemotherapy: Targeted Delivery of Doxorubicin via a Dual Functional Nanocarrier. therapeutic application,unassigned 2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29031064&form=6&db=m Fragment-based approach to identify IDO1 inhibitor building blocks. causal interaction,unassigned 2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29120388&form=6&db=m Synthesis and Molecular Modeling Studies of N'-Hydroxyindazolecarboximidamides as Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29133053&form=6&db=m Synthesis and biological evaluation of new berberine derivatives as cancer immunotherapy agents through targeting IDO1. ongoing research,therapeutic application,unassigned 1,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29156701&form=6&db=m Association of breast carcinoma growth with a non-canonical axis of IFN?/IDO1/TSP1. diagnostic usage,unassigned 2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29167110&form=6&db=m Blocking IDO1 Helps Shrink Bladder, Cervical Tumors. therapeutic application,unassigned 2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29167421&form=6&db=m Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29177308&form=6&db=m Discovery of IDO1 and DNA dual targeting antitumor agents. therapeutic application,unassigned 2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29473428&form=6&db=m A patent review of IDO1 inhibitors for cancer. ongoing research,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29498788&form=6&db=m High IDO-1 Expression in Tumor Endothelial Cells is Associated with Response to Immunotherapy in Metastatic Renal Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29722898&form=6&db=m LW106, a novel indoleamine 2,3-dioxygenase 1 inhibitor, suppresses tumour progression by limiting stroma-immune crosstalk and cancer stem cell enrichment in tumour micro-environment. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29746927&form=6&db=m Indoleamine 2,3-dioxygenase 1 inhibition targets anti-PD1-resistant lung tumors by blocking myeloid-derived suppressor cells. causal interaction,ongoing research,unassigned 2,2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29805749&form=6&db=m Indoleamine 2,3-dioxygenase 1 and overall survival of patients diagnosed with esophageal cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29901571&form=6&db=m Indoleamine-2,3-Dioxygenase in Non-Small Cell Lung Cancer: A Targetable Mechanism of Immune Resistance Frequently Coexpressed With PD-L1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29921320&form=6&db=m Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors. ongoing research,therapeutic application,unassigned 2,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29930558&form=6&db=m Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8?+ T Cells and Differentiated ?? T Cells Alongside a Regulatory Response Mediated by FOXP3+ T Cells and Immunoregulatory Molecules. ongoing research,therapeutic application,unassigned 2,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29932010&form=6&db=m A highly potent and selective inhibitor Roxyl-WL targeting IDO1 promotes immune response against melanoma. causal interaction,unassigned 2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30010674&form=6&db=m Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme. therapeutic application,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30014971&form=6&db=m Indoleamine 2,3-dioxygenase 1 and programmed cell death-ligand 1 co-expression correlates with aggressive features in lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30040142&form=6&db=m The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by ?-PD-L1 or ?-IL6 antibodies. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30063262&form=6&db=m Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment. therapeutic application,unassigned 2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30103191&form=6&db=m Design, synthesis and biological evaluation of novel naphthoquinone derivatives as IDO1 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30108849&form=6&db=m Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry. ongoing research,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30108875&form=6&db=m Synthesis and evaluation of oxindoles as promising inhibitors of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30134247&form=6&db=m TDO2 Overexpression Is Associated with Cancer Stem Cells and Poor Prognosis in Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,unassigned 1,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30150994&form=6&db=m What May Constrain the Success of Indoleamine 2,3-Dioxygenase 1 Inhibitors in Cancer Immunotherapy? therapeutic application,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30170925&form=6&db=m Design, synthesis and structure-activity relationship study of novel naphthoindolizine and indolizinoquinoline-5,12-dione derivatives as IDO1 inhibitors. diagnostic usage,therapeutic application,unassigned 1,2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30265610&form=6&db=m Epacadostat Plus Pembrolizumab in Patients With Advanced Solid Tumors: Phase I Results From a Multicenter, Open-Label Phase I/II Trial (ECHO-202/KEYNOTE-037). causal interaction,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30275755&form=6&db=m Eicosapentaenoic acid reduces indoleamine 2,3-dioxygenase 1 expression in tumor cells. causal interaction,ongoing research,unassigned 1,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30321802&form=6&db=m Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives. causal interaction,therapeutic application,unassigned 3,2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30338242&form=6&db=m Updates in the Clinical Development of Epacadostat and Other Indoleamine 2,3-Dioxygenase 1 Inhibitors (IDO1) for Human Cancers. causal interaction,diagnostic usage,unassigned 1,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30347977&form=6&db=m Mapping the Binding Trajectory of a Suicide Inhibitor in Human Indoleamine 2,3-Dioxygenase 1. causal interaction,therapeutic application,unassigned 3,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30387777&form=6&db=m High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form. causal interaction,therapeutic application,unassigned 3,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30448912&form=6&db=m Assessment of TILs, IDO-1, and PD-L1 in resected non-small cell lung cancer: an immunohistochemical study with clinicopathological and prognostic implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30468988&form=6&db=m OKN-007 Increases temozolomide (TMZ) Sensitivity and Suppresses TMZ-Resistant Glioblastoma (GBM) Tumor Growth. ongoing research,unassigned 2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30524887&form=6&db=m Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation. ongoing research,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30594037&form=6&db=m Overexpression of Indoleamine 2,3-Dioxygenase 1 Promotes Epithelial-Mesenchymal Transition by Activation of the IL-6/STAT3/PD-L1 Pathway in Bladder Cancer. causal interaction,unassigned 4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30659394&form=6&db=m Indoleamine Dioxygenase Inhibitors: Clinical Rationale and Current Development. causal interaction,therapeutic application,unassigned 1,2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30671955&form=6&db=m Investigation of indolamine 2, 3 dioxygenase (IDO-1) gene expression by real-time PCR among patients with lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30760888&form=6&db=m Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30770348&form=6&db=m Phase I Study of the Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Navoximod (GDC-0919) Administered with PD-L1 Inhibitor (Atezolizumab) in Advanced Solid Tumors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30773421&form=6&db=m 4,6-Substituted-1H-Indazoles as potent IDO1/TDO dual inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30852385&form=6&db=m Multifunctional platinum(IV) complexes as immunostimulatory agents to promote cancer immunochemotherapy by inhibiting tryptophan-2,3-dioxygenase. therapeutic application,unassigned 2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30858027&form=6&db=m Design, synthesis and biological evaluation of 2,5-dimethylfuran-3-carboxylic acid derivatives as potential IDO1 inhibitors. therapeutic application,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30905636&form=6&db=m IDO1 Inhibition Overcomes Radiation-Induced "Rebound Immune Suppression" by Reducing Numbers of IDO1-Expressing Myeloid-Derived Suppressor Cells in the Tumor Microenvironment. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30952082&form=6&db=m Pt(IV) hybrids containing a TDO inhibitor serve as potential anticancer immunomodulators. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30990966&form=6&db=m Capping Silica Nanoparticles with Tryptophan-Mediated Cucurbit[8]uril Complex for Targeted Intracellular Drug Delivery Triggered by Tumor-Overexpressed IDO1 Enzyme. causal interaction,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30997445&form=6&db=m Folated pH-degradable nanogels for the simultaneous delivery of docetaxel and an IDO1-inhibitor in enhancing cancer chemo-immunotherapy. ongoing research,therapeutic application,unassigned 1,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31063649&form=6&db=m The next-generation BET inhibitor, PLX51107, delays melanoma growth in a CD8-mediated manner. causal interaction,ongoing research,unassigned 3,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31103493&form=6&db=m Rational design, synthesis and biological evaluation of ubiquinone derivatives as IDO1 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31112568&form=6&db=m Inhibition of immune checkpoints PD-1, CTLA-4, and IDO1 coordinately induces immune-mediated liver injury in mice. ongoing research,unassigned 2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31124055&form=6&db=m Phase I study of the indoleamine 2,3-dioxygenase 1 inhibitor navoximod (GDC-0919) as monotherapy and in combination with the PD-L1 inhibitor atezolizumab in Japanese patients with advanced solid tumours. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31124390&form=6&db=m Fecal microbiota transplantation from chronic unpredictable mild stress mice donors affects anxiety-like and depression-like behavior in recipient mice via the gut microbiota-inflammation-brain axis. ongoing research,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31197246&form=6&db=m Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31324754&form=6&db=m Inhibition of the BET family reduces its new target gene IDO1 expression and the production of L-kynurenine. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31383907&form=6&db=m The silencing of indoleamine 2,3-dioxygenase 1 (IDO1) in dendritic cells by siRNA-loaded lipid nanoparticles enhances cell-based cancer immunotherapy. ongoing research,unassigned 2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31423683&form=6&db=m Self-Amplified Drug Delivery with Light-Inducible Nanocargoes to Enhance Cancer Immunotherapy. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31423846&form=6&db=m Inhibitory effects of flavonoids isolated from Sophora flavescens on indoleamine 2,3-dioxygenase 1 activity. causal interaction,diagnostic usage,unassigned 3,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31445192&form=6&db=m Novel conjugates with dual suppression of glutathione S-transferases and tryptophan-2,3-dioxygenase activities for improving hepatocellular carcinoma therapy. causal interaction,therapeutic application,unassigned 3,2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31445231&form=6&db=m Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer. therapeutic application,unassigned 4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31512038&form=6&db=m Fluorine-18-Labeled PET Radiotracers for Imaging Tryptophan Uptake and Metabolism: a Systematic Review. ongoing research,therapeutic application,unassigned 1,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31580660&form=6&db=m N-Benzyl/Aryl Substituted Tryptanthrin as Dual Inhibitors of Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase. therapeutic application,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31610376&form=6&db=m Effective Virtual Screening Strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors. causal interaction,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31628024&form=6&db=m DNA methylation of indoleamine 2,3-dioxygenase 1 (IDO1) in head and neck squamous cell carcinomas correlates with IDO1 expression, HPV status, patients' survival, immune cell infiltrates, mutational load, and interferon ? signature. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31722750&form=6&db=m Development and validation of an immune checkpoint-based signature to predict prognosis in nasopharyngeal carcinoma using computational pathology analysis. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31785855&form=6&db=m Design, synthesis and biological evaluation of bicyclic carboxylic acid derivatives as IDO1 inhibitors. therapeutic application,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31793787&form=6&db=m Sheddable Prodrug Vesicles Combating Adaptive Immune Resistance for Improved Photodynamic Immunotherapy of Cancer. causal interaction,therapeutic application,unassigned 2,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31795096&form=6&db=m Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31798304&form=6&db=m Tryptophan Metabolism as Source of New Prognostic Biomarkers for FAP Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31804586&form=6&db=m 4,5-Disubstituted 1,2,3-triazoles: Effective Inhibition of Indoleamine 2,3-Dioxygenase 1 Enzyme Regulates T cell Activity and Mitigates Tumor Growth. causal interaction,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31806639&form=6&db=m Tryptophan 2,3-Dioxygenase Expression Identified in Human Hepatocellular Carcinoma Cells and in Intratumoral Pericytes of Most Cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31830637&form=6&db=m Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenase. therapeutic application,unassigned 4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31881488&form=6&db=m Design, synthesis and biological evaluation of indole-2-carboxylic acid derivatives as IDO1/TDO dual inhibitors. causal interaction,therapeutic application,unassigned 3,2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31903023&form=6&db=m Induction of tryptophan 2,3-dioxygenase expression in human monocytic leukemia/lymphoma cell lines THP-1 and U937. causal interaction,diagnostic usage,unassigned 4,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31981851&form=6&db=m Design, synthesis, and biological evaluation of 1,2,5-oxadiazole-3-carboximidamide derivatives as novel indoleamine-2,3-dioxygenase 1 inhibitors. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31997472&form=6&db=m Induction of tryptophan hydroxylase in the liver of s.c. tumor model of prostate cancer. ongoing research,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32004652&form=6&db=m Triple drugs co-delivered by a small gemcitabine-based carrier for pancreatic cancer immunochemotherapy. therapeutic application,unassigned 4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32010873&form=6&db=m Metabolomic Analysis of the Effects of Leptin Replacement Therapy in Patients with Lipodystrophy. therapeutic application,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32055299&form=6&db=m Recent advances in the discovery of indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32085927&form=6&db=m Landscape of Immune Checkpoint Inhibition in Carcinosarcoma (MMMT): Analysis of IDO-1, PD-L1 and PD-1. diagnostic usage,ongoing research,unassigned 3,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32088128&form=6&db=m Discovery of novel hydroxyamidine derivatives as indoleamine 2,3-dioxygenase 1 inhibitors with in vivo anti-tumor efficacy. causal interaction,therapeutic application,unassigned 3,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32125093&form=6&db=m Up-regulation of indoleamine 2,3-dioxygenase 1 (IDO1) expression and catalytic activity is associated with immunosuppression and poor prognosis in penile squamous cell carcinoma patients. causal interaction,diagnostic usage,unassigned 4,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32210078&form=6&db=m Design, Synthesis and Biological Evaluation of Phenyl Urea Derivatives as IDO1 Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32247733&form=6&db=m Synthesis of novel tryptanthrin derivatives as dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase. causal interaction,therapeutic application,unassigned 3,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32260340&form=6&db=m Prognostic Impact of Tumor-Associated Macrophages on Survival Is Checkpoint Dependent in Classical Hodgkin Lymphoma. diagnostic usage,ongoing research,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32328426&form=6&db=m Supramolecular Prodrug Nanovectors for Active Tumor Targeting and Combination Immunotherapy of Colorectal Cancer. ongoing research,therapeutic application,unassigned 1,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32346606&form=6&db=m Comprehensive Analysis of the Expressionand Prognosis for TDO2 in Breast Cancer. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32360490&form=6&db=m Programmed death ligand 1/indoleamine 2,3-dioxygenase 1 expression and tumor-infiltrating lymphocyte status in renal cell carcinoma with sarcomatoid changes and rhabdoid features. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32382333&form=6&db=m Gene silencing of indoleamine 2,3-dioxygenase 1 inhibits lung cancer growth by suppressing T-cell exhaustion. causal interaction,ongoing research,unassigned 1,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32388585&form=6&db=m PD-L1 and IDO1 expression and tumor-infiltrating lymphocytes in osteosarcoma patients: comparative study of primary and metastatic lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32414944&form=6&db=m Prognostic impact of indoleamine 2,3-dioxygenase 1 (IDO1) mRNA expression on circulating tumour cells of patients with head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32466694&form=6&db=m Discovery of secondary sulphonamides as IDO1 inhibitors with potent antitumour effects in vivo. causal interaction,therapeutic application,unassigned 1,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32477324&form=6&db=m Constitutive Expression of the Immunosuppressive Tryptophan Dioxygenase TDO2 in Glioblastoma Is Driven by the Transcription Factor C/EBP?. causal interaction,therapeutic application,unassigned 4,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32481253&form=6&db=m IDO, TDO, and AHR overexpression is associated with poor outcome in diffuse large B-cell lymphoma patients in the rituximab era. diagnostic usage,ongoing research,unassigned 2,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32545442&form=6&db=m Reciprocal Regulation Between Indoleamine 2,3-Dioxigenase 1 and Notch1 Involved in Radiation Response of Cervical Cancer Stem Cells. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32563943&form=6&db=m Oxaliplatin-/NLG919 prodrugs-constructed liposomes for effective chemo-immunotherapy of colorectal cancer. causal interaction,diagnostic usage,unassigned 4,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32568559&form=6&db=m Advances in the discovery and development of selective heme-displacing IDO1 inhibitors. therapeutic application,unassigned 4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32659257&form=6&db=m News on immune checkpoint inhibitors as immunotherapy strategies in adult and pediatric solid tumors. diagnostic usage,ongoing research,unassigned 3,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32675194&form=6&db=m Interrogating the immune-modulating roles of radiation therapy for a rational combination with immune-checkpoint inhibitors in treating pancreatic cancer. therapeutic application,unassigned 4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32683062&form=6&db=m Indoleamine 2,3-Dioxygenase-1 Expression in Adrenocortical Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32776284&form=6&db=m Different effects of tryptophan 2,3-dioxygenase inhibition on SK-Mel-28 and HCT-8 cancer cell lines. ongoing research,therapeutic application,unassigned 4,2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32782249&form=6&db=m Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32842025&form=6&db=m Clinical Significance of Program Death Ligand-1 and Indoleamine-2,3-Dioxygenase Expression in Colorectal Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,3 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32843490&form=6&db=m Preclinical investigations and a first-in-human phase I trial of M4112, the first dual inhibitor of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2, in patients with advanced solid tumors. therapeutic application,unassigned 4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32871341&form=6&db=m Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO). causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32940915&form=6&db=m Clinical significance of tryptophan catabolism in follicular lymphoma. causal interaction,therapeutic application,unassigned 2,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32951108&form=6&db=m Association of PD-L1 and IDO1 expression with JAK-STAT pathway activation in soft-tissue leiomyosarcoma. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32987253&form=6&db=m Immunosuppressive profiles in liquid biopsy at diagnosis predict response to neoadjuvant chemotherapy in triple-negative breast cancer. causal interaction,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32991179&form=6&db=m Unconventional [2 + 3] Cyclization Involving [1,4]-Sulfonyl Transfer to Construct Polysubstituted Fluorazones as Inhibitors of Indoleamine 2,3-Dioxygenase 1. therapeutic application,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33101032&form=6&db=m Discovery of Icotinib-1,2,3-Triazole Derivatives as IDO1 Inhibitors. causal interaction,therapeutic application,unassigned 3,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33125511&form=6&db=m Characterization of the tumor immune microenvironment in human papillomavirus-positive and -negative head and neck squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33142415&form=6&db=m Evaluation and comparison of the commonly used bioassays of human indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO). causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33151286&form=6&db=m Effect of Taxane Chemotherapy With or Without Indoximod in Metastatic Breast Cancer: A Randomized Clinical Trial. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33163345&form=6&db=m Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1. causal interaction,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33166111&form=6&db=m Fighting Immune Cold and Reprogramming Immunosuppressive Tumor Microenvironment with Red Blood Cell Membrane-Camouflaged Nanobullets. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33215494&form=6&db=m Development of Indoleamine 2,3-Dioxygenase 1 Inhibitors for Cancer Therapy and Beyond: A Recent Perspective. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33236625&form=6&db=m Self-Delivery Photo-Immune Stimulators for Photodynamic Sensitized Tumor Immunotherapy. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33263327&form=6&db=m Influence of the presence of the heme cofactor on the JK-loop structure in indoleamine 2,3-dioxygenase 1. causal interaction,therapeutic application,unassigned 2,2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33298590&form=6&db=m Preclinical Characterization of Linrodostat Mesylate, a Novel, Potent, and Selective Oral Indoleamine 2,3-Dioxygenase 1 Inhibitor. therapeutic application,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33326535&form=6&db=m Inhibition of immunosuppressive indoleamine 2,3-dioxygenase by targeting the heme and apo-form. causal interaction,therapeutic application,unassigned 1,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33363543&form=6&db=m Tryptophan 2,3-Dioxygenase Expression Identified in Murine Decidual Stromal Cells Is Not Essential for Feto-Maternal Tolerance. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33410234&form=6&db=m Tryptophan 2,3-dioxygenase in tumor cells is associated with resistance to immunotherapy in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33482599&form=6&db=m A theranostic probe of indoleamine 2,3-dioxygenase 1 (IDO1) for small molecule cancer immunotherapy. diagnostic usage,unassigned 2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33540035&form=6&db=m Hybrid micelles codelivering shikonin and IDO-1 siRNA enhance immunotherapy by remodeling immunosuppressive tumor microenvironment. therapeutic application,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33541164&form=6&db=m Reliable chromatographic assay for measuring of indoleamine 2,3-dioxygenase 1 (IDO1) activity in human cancer cells. diagnostic usage,ongoing research,unassigned 4,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33542896&form=6&db=m TDO2 Promotes the EMT of Hepatocellular Carcinoma Through Kyn-AhR Pathway. causal interaction,therapeutic application,unassigned 3,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33603977&form=6&db=m Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33634987&form=6&db=m Forty-three key gene expressions involved in the effect of indoleamine 2,3-dioxygenase 1 expression on cancer prognosis may be a potential indoleamine 2,3-dioxygenase 1 inhibitor biomarker. causal interaction,therapeutic application,unassigned 2,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33638642&form=6&db=m Inhibitory investigation of niacin derivatives on metalloenzyme indoleamine 2,3-dioxygenase 1 for its immunomodulatory function. therapeutic application,unassigned 4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33665222&form=6&db=m Inhibition of indoleamine 2,3-dioxygenase 1 synergizes with oxaliplatin for efficient colorectal cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33671892&form=6&db=m High PD-L1/IDO-2 and PD-L2/IDO-1 Co-Expression Levels Are Associated with Worse Overall Survival in Resected Non-Small Cell Lung Cancer Patients. ongoing research,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33692219&form=6&db=m N-cadherin inhibitor creates a microenvironment that protect TILs from immune checkpoints and Treg cells. ongoing research,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33708223&form=6&db=m Tryptophan: A Rheostat of Cancer Immune Escape Mediated by Immunosuppressive Enzymes IDO1 and TDO. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33738077&form=6&db=m Discovery of Imidazopyridines as Potent Inhibitors of Indoleamine 2,3-Dioxygenase 1 for Cancer Immunotherapy. causal interaction,therapeutic application,unassigned 4,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33759400&form=6&db=m A Series of 2-((1-Phenyl-1H-imidazol-5-yl)methyl)-1H-indoles as Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors. therapeutic application,unassigned 3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33804161&form=6&db=m Novel Selective IDO1 Inhibitors with Isoxazolo[5,4-d]pyrimidin-4(5H)-one Scaffold. therapeutic application,unassigned 2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33806305&form=6&db=m Dexamethasone Induces the Expression and Function of Tryptophan-2-3-Dioxygenase in SK-MEL-28 Melanoma Cells. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33870196&form=6&db=m Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells. causal interaction,therapeutic application,unassigned 3,2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33883013&form=6&db=m Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy. diagnostic usage,therapeutic application,unassigned 1,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33901770&form=6&db=m Parallel discovery of selective and dual inhibitors of tryptophan dioxygenases IDO1 and TDO2 with a newly-modified enzymatic assay. diagnostic usage,unassigned 2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33922995&form=6&db=m Immunomodulatory Factors in Primary Endometrial Cell Cultures Isolated from Cancer and Noncancerous Human Tissue-Focus on RAGE and IDO1. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33928928&form=6&db=m A Phase I Study of an IDO-1 Inhibitor (LY3381916) as Monotherapy and in Combination With an Anti-PD-L1 Antibody (LY3300054) in Patients With Advanced Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,4 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33968089&form=6&db=m Current Challenges for IDO2 as Target in Cancer Immunotherapy. causal interaction,therapeutic application,unassigned 3,2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34018715&form=6&db=m Retraction of "Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway". ongoing research,therapeutic application,unassigned 1,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34021461&form=6&db=m Indoleamine 2,3-Dioxygenase 1 (IDO1) Promotes Cardiac Hypertrophy via a PI3K-AKT-mTOR-Dependent Mechanism. diagnostic usage,unassigned 1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34101386&form=6&db=m TDO2 overexpression correlates with poor prognosis, cancer stemness, and resistance to cetuximab in bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34146889&form=6&db=m Self-delivery oxidative stress amplifier for chemotherapy sensitized immunotherapy. unassigned - 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34147833&form=6&db=m On-line screening of indoleamine 2,3-dioxygenase 1 inhibitors by partial filling capillary electrophoresis combined with rapid polarity switching. causal interaction,therapeutic application,unassigned 3,3,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34285260&form=6&db=m Tumor microenvironment in giant cell tumor of bone: evaluation of PD-L1 expression and SIRP? infiltration after denosumab treatment. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34355531&form=6&db=m The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors. causal interaction,therapeutic application,unassigned 1,4,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34367262&form=6&db=m Genomic and Immunologic Correlates of Indoleamine 2,3-Dioxygenase Pathway Expression in Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34386086&form=6&db=m Inhibition of photodynamic therapy induced-immunosuppression with aminolevulinic acid leads to enhanced outcomes of tumors and pre-cancerous lesions. therapeutic application,unassigned 2,0 1.13.11.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34539663&form=6&db=m Targeting Indoleamine 2,3-Dioxygenase 1: Fighting Cancers via Dormancy Regulation. causal interaction,unassigned 3,0 1.13.11.11 Neoplastic Cells, Circulating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32414944&form=6&db=m Prognostic impact of indoleamine 2,3-dioxygenase 1 (IDO1) mRNA expression on circulating tumour cells of patients with head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.13.11.11 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25313323&form=6&db=m Crystal Structures and Structure-Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30426184&form=6&db=m Ameliorative effect of fisetin against lipopolysaccharide and restraint stress-induced behavioral deficits via modulation of NF-?B and IDO-1. therapeutic application,unassigned 3,0 1.13.11.11 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31103493&form=6&db=m Rational design, synthesis and biological evaluation of ubiquinone derivatives as IDO1 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25637485&form=6&db=m Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice. ongoing research,therapeutic application,unassigned 4,1,0 1.13.11.11 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32842609&form=6&db=m The Role of the Kynurenine Signaling Pathway in Different Chronic Pain Conditions and Potential Use of Therapeutic Agents. unassigned - 1.13.11.11 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30321802&form=6&db=m Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives. causal interaction,therapeutic application,unassigned 3,2,0 1.13.11.11 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30760888&form=6&db=m Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. unassigned - 1.13.11.11 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32247733&form=6&db=m Synthesis of novel tryptanthrin derivatives as dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase. causal interaction,therapeutic application,unassigned 3,3,0 1.13.11.11 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27870896&form=6&db=m M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus. causal interaction,therapeutic application,unassigned 4,1,0 1.13.11.11 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32024760&form=6&db=m Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation. ongoing research,unassigned 4,0 1.13.11.11 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32067945&form=6&db=m Exogenous melatonin restrains neuroinflammation in high fat diet induced diabetic rats through attenuating indoleamine 2,3-dioxygenase 1 expression. unassigned - 1.13.11.11 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33774066&form=6&db=m IDO-1 inhibition protects against neuroinflammation, oxidative stress and mitochondrial dysfunction in 6-OHDA induced murine model of Parkinson's disease. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 1.13.11.11 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27020609&form=6&db=m Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGF?, and IDO1. causal interaction,ongoing research,unassigned 2,2,0 1.13.11.11 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29141444&form=6&db=m Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy. unassigned - 1.13.11.11 Obesity, Maternal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29141444&form=6&db=m Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy. unassigned - 1.13.11.11 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31736606&form=6&db=m Tryptophan catabolism in epithelial ovarian carcinoma. causal interaction,unassigned 1,0 1.13.11.11 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34520819&form=6&db=m IDO1/TDO dual inhibitor RY103 targets Kyn-AhR pathway and exhibits preclinical efficacy on pancreatic cancer. causal interaction,diagnostic usage,unassigned 1,3,0 1.13.11.11 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34367262&form=6&db=m Genomic and Immunologic Correlates of Indoleamine 2,3-Dioxygenase Pathway Expression in Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 1.13.11.11 Papillomavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31412167&form=6&db=m Indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase expression in HPV infection, SILs, and cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 1.13.11.11 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33774066&form=6&db=m IDO-1 inhibition protects against neuroinflammation, oxidative stress and mitochondrial dysfunction in 6-OHDA induced murine model of Parkinson's disease. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 1.13.11.11 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34110158&form=6&db=m X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease. therapeutic application,unassigned 2,0 1.13.11.11 Persistent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30108875&form=6&db=m Synthesis and evaluation of oxindoles as promising inhibitors of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Porphyrias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1567472&form=6&db=m Effects of acute carbamazepine administration on haem metabolism in rat liver. therapeutic application,unassigned 1,0 1.13.11.11 Porphyrias, Hepatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31443750&form=6&db=m Hypothesis: Metabolic targeting of 5-aminolevulinate synthase by tryptophan and inhibitors of heme utilisation by tryptophan 2,3-dioxygenase as potential therapies of acute hepatic porphyrias. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 1.13.11.11 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31703602&form=6&db=m Distinct tumor microenvironments of lytic and blastic bone metastases in prostate cancer patients. diagnostic usage,therapeutic application,unassigned 3,3,0 1.13.11.11 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32752186&form=6&db=m Indoleamine 2,3-Dioxygenase 2 Deficiency Exacerbates Imiquimod-Induced Psoriasis-Like Skin Inflammation. causal interaction,unassigned 4,0 1.13.11.11 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33804147&form=6&db=m Psoriasis: Pathogenesis, Comorbidities, and Therapy Updated. causal interaction,unassigned 1,0 1.13.11.11 Purpura, Thrombocytopenic, Idiopathic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22936460&form=6&db=m Decreased expression of indoleamine 2,3-dioxygenase 1 in dendritic cells contributes to impaired regulatory T cell development in immune thrombocytopenia. ongoing research,unassigned 3,0 1.13.11.11 Rhabdomyolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16846079&form=6&db=m Free heme pool and activity of key enzyme of heme synthesis in the rat liver under action of agents affecting reduced glutathione level. unassigned - 1.13.11.11 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27161289&form=6&db=m Tryptophan Metabolism in Allergic Disorders. causal interaction,therapeutic application,unassigned 4,1,0 1.13.11.11 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30623620&form=6&db=m Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,1,0 1.13.11.11 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32313727&form=6&db=m Tumor-associated macrophages and macrophage-related immune checkpoint expression in sarcomas. causal interaction,therapeutic application,unassigned 3,3,0 1.13.11.11 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30770561&form=6&db=m Indoleamine 2,3-dioxygenase 1 deletion promotes Theiler's virus-induced seizures in C57BL/6J mice. unassigned - 1.13.11.11 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21765346&form=6&db=m Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3 1.13.11.11 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30279361&form=6&db=m Effects of 1-Methyltryptophan on Immune Responses and the Kynurenine Pathway after Lipopolysaccharide Challenge in Pigs. causal interaction,unassigned 4,0 1.13.11.11 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21765346&form=6&db=m Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3 1.13.11.11 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30154146&form=6&db=m Human papilloma virus specific immunogenicity and dysfunction of CD8+ T cells in head and neck cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 1.13.11.11 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31628024&form=6&db=m DNA methylation of indoleamine 2,3-dioxygenase 1 (IDO1) in head and neck squamous cell carcinomas correlates with IDO1 expression, HPV status, patients' survival, immune cell infiltrates, mutational load, and interferon ? signature. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.13.11.11 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32414944&form=6&db=m Prognostic impact of indoleamine 2,3-dioxygenase 1 (IDO1) mRNA expression on circulating tumour cells of patients with head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.13.11.11 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33125511&form=6&db=m Characterization of the tumor immune microenvironment in human papillomavirus-positive and -negative head and neck squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 1.13.11.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6477476&form=6&db=m The influence of starvation and tryptophan administration on the metabolism of phenylalanine, tyrosine and tryptophan in isolated rat liver cells. unassigned - 1.13.11.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25881064&form=6&db=m Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers. unassigned - 1.13.11.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27696702&form=6&db=m Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1. unassigned - 1.13.11.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31685866&form=6&db=m Role of indoleamine 2,3-dioxygenase in testicular immune-privilege. causal interaction,unassigned 3,0 1.13.11.11 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30349892&form=6&db=m Indoleamine 2,3-dioxygenase 1 in coronary atherosclerotic plaque enhances tissue factor expression in activated macrophages. causal interaction,unassigned 4,0 1.13.11.11 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24517146&form=6&db=m INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IS UPREGULATED IN THYROID CARCINOMA AND DRIVES THE DEVELOPMENT OF AN IMMUNOSUPPRESSANT TUMOR MICROENVIRONMENT. causal interaction,unassigned 3,0 1.13.11.11 Thyroiditis, Autoimmune http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32480225&form=6&db=m Prunella vulgaris L. attenuates experimental autoimmune thyroiditis by inducing indoleamine 2,3-dioxygenase 1 expression and regulatory T cell expansion. ongoing research,therapeutic application,unassigned 4,1,0 1.13.11.11 Tourette Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8873217&form=6&db=m Exon and intron variants in the human tryptophan 2,3-dioxygenase gene: potential association with Tourette syndrome, substance abuse and other disorders. unassigned - 1.13.11.11 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28123606&form=6&db=m Strong Correlation of Indoleamine 2,3-Dioxygenase 1 Expression with Basal-Like Phenotype and Increased Lymphocytic Infiltration in Triple-Negative Breast Cancer. causal interaction,unassigned 3,0 1.13.11.11 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30213797&form=6&db=m Reversal of Triple-negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immune-Suppression. therapeutic application,unassigned 1,0 1.13.11.11 tryptophan 2,3-dioxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28285122&form=6&db=m Hypertryptophanemia due to tryptophan 2,3-dioxygenase deficiency. causal interaction,unassigned 4,0 1.13.11.11 tryptophan 2,3-dioxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28465467&form=6&db=m Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl4-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 1.13.11.11 tryptophan 2,3-dioxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32752186&form=6&db=m Indoleamine 2,3-Dioxygenase 2 Deficiency Exacerbates Imiquimod-Induced Psoriasis-Like Skin Inflammation. causal interaction,unassigned 4,0 1.13.11.11 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22649518&form=6&db=m M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. causal interaction,ongoing research,unassigned 3,4,0 1.13.11.11 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30594037&form=6&db=m Overexpression of Indoleamine 2,3-Dioxygenase 1 Promotes Epithelial-Mesenchymal Transition by Activation of the IL-6/STAT3/PD-L1 Pathway in Bladder Cancer. causal interaction,unassigned 4,0 1.13.11.11 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31355138&form=6&db=m MicroRNA-153 Decreases Tryptophan Catabolism and Inhibits Angiogenesis in Bladder Cancer by Targeting Indoleamine 2,3-Dioxygenase 1. diagnostic usage,ongoing research,unassigned 3,4,0 1.13.11.11 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32770708&form=6&db=m Combination Bacillus Calmette-Guérin and indoleamine 2,3-dioxygenase 1 inhibitor therapy of murine orthotopic bladder cancer. diagnostic usage,ongoing research,unassigned 3,1,0 1.13.11.11 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32794357&form=6&db=m Tryptophan-kynurenine ratio as a biomarker of bladder cancer. diagnostic usage,ongoing research,unassigned 3,3,0 1.13.11.11 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31412167&form=6&db=m Indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase expression in HPV infection, SILs, and cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 1.13.11.11 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28697066&form=6&db=m Viral-induced Modulation of Multiple Checkpoint Proteins in Cancers. diagnostic usage,ongoing research,unassigned 1,2,0 1.13.11.11 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31103493&form=6&db=m Rational design, synthesis and biological evaluation of ubiquinone derivatives as IDO1 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 1.13.11.11 Vitamin B 6 Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4026305&form=6&db=m The effect of pyridoxine deficiency on the metabolism of the aromatic amino acids by isolated rat liver cells. causal interaction,unassigned 4,0 1.13.11.11 Vitamin B 6 Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34251022&form=6&db=m Multiple roles of haem in cystathionine ?-synthase activity: implications for hemin and other therapies of acute hepatic porphyria. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 1.13.11.11 Zika Virus Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29262327&form=6&db=m Transcriptional Changes during Naturally Acquired Zika Virus Infection Render Dendritic Cells Highly Conducive to Viral Replication. unassigned -