1.11.1.24 Abortion, Habitual http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28661480&form=6&db=m Role of peroxiredoxin2 downregulation in recurrent miscarriage through regulation of trophoblast proliferation and apoptosis. causal interaction,diagnostic usage,unassigned 2,1,0 1.11.1.24 Abortion, Habitual http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33421846&form=6&db=m Association of glutamate cystein ligase (GCL) activity Peroxiredoxin 4 (prxR4) and apelin levels in women with preeclampsia. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 1.11.1.24 Abortion, Spontaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16738225&form=6&db=m Proteomic analysis on the alteration of protein expression in the placental villous tissue of early pregnancy loss. unassigned - 1.11.1.24 Abortion, Spontaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25323516&form=6&db=m Preoxiredoxin family members (Prx3 and Prx4) and pregnancy disorder (recurrent pregnancy loss). ongoing research,unassigned 1,0 1.11.1.24 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24444602&form=6&db=m Attenuation of hydrogen peroxide-mediated oxidative stress by Brassica juncea annexin-3 counteracts thiol-specific antioxidant (TSA1) deficiency in Saccharomyces cerevisiae. ongoing research,therapeutic application,unassigned 1,2,0 1.11.1.24 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33747176&form=6&db=m MicroRNA-383 promotes reactive oxygen species-induced autophagy via downregulating peroxiredoxin 3 in human glioma U87 cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 1.11.1.24 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22177494&form=6&db=m [Roles of peroxiredoxin 6 in the regulation of oxidative stress to lipopolysaccharide-induced acute lung injury]. ongoing research,unassigned 2,0 1.11.1.24 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28485790&form=6&db=m Peroxiredoxin 1 inhibits lipopolysaccharide-induced oxidative stress in lung tissue by regulating P38/JNK signaling pathway. causal interaction,ongoing research,unassigned 4,2,0 1.11.1.24 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30683539&form=6&db=m Peroxiredoxin 6 knockout aggravates cecal ligation and puncture-induced acute lung injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,1 1.11.1.24 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15239128&form=6&db=m Peroxiredoxins, a novel protein family in lung cancer. causal interaction,diagnostic usage,unassigned 4,4,0 1.11.1.24 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23065574&form=6&db=m ILK and PRDX1 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder. ongoing research,therapeutic application,unassigned 4,1,0 1.11.1.24 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23186333&form=6&db=m Prx I suppresses K-ras-driven lung tumorigenesis by opposing redox-sensitive ERK/cyclin D1 pathway. causal interaction,therapeutic application,unassigned 3,3,0 1.11.1.24 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25426613&form=6&db=m Peroxiredoxin 1 Promotes Pancreatic Cancer Cell Invasion by Modulating p38 MAPK Activity. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 1.11.1.24 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26261544&form=6&db=m Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 1.11.1.24 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26722077&form=6&db=m Loss of Peroxiredoxin Expression Is Associated with an Aggressive Phenotype in Pancreatic Adenocarcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 1.11.1.24 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30214590&form=6&db=m Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.11.1.24 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31197039&form=6&db=m Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades. ongoing research,unassigned 3,0 1.11.1.24 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31280208&form=6&db=m Peroxiredoxin V Inhibits Emodin-induced Gastric Cancer Cell Apoptosis via the ROS/Bcl2 Pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,1 1.11.1.24 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31436131&form=6&db=m Elucidation of the AGR2 Interactome in Esophageal Adenocarcinoma Cells Identifies a Redox-Sensitive Chaperone Hub for the Quality Control of MUC-5AC. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32908916&form=6&db=m PRDX2 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer In Vitro and In Vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 1.11.1.24 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33813388&form=6&db=m Peroxiredoxin V Silencing Elevates Susceptibility to Doxorubicin-induced Cell Apoptosis via ROS-dependent Mitochondrial Dysfunction in AGS Gastric Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19556853&form=6&db=m Production and radioimmunoimaging of novel fully human phage display recombinant antibodies and growth inhibition of lung adenocarcinoma cell line overexpressing Prx I. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 1.11.1.24 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19799814&form=6&db=m Inhibitory effect of novel internalized fully human phage antibody fragments on proliferation of lung adenocarcinoma cell line overexpressing peroxiredoxin I. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 1.11.1.24 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20117978&form=6&db=m [Preparation and characterization of human phage display antibody against peroxiredoxin I of lung adenocarcinoma] diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 1.11.1.24 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25607351&form=6&db=m Downregulation of peroxiredoxin-1 by ?-elemene enhances the radiosensitivity of lung adenocarcinoma xenografts. causal interaction,therapeutic application,unassigned 3,4,0 1.11.1.24 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26810067&form=6&db=m DACH1 inhibits the proliferation and invasion of lung adenocarcinoma through the downregulation of peroxiredoxin 3. causal interaction,ongoing research,unassigned 2,1,0 1.11.1.24 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30568461&form=6&db=m Prognostic roles of mRNA expression of peroxiredoxins in lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.11.1.24 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31588184&form=6&db=m The impact of PRDX4 and the EGFR mutation status on cellular proliferation in lung adenocarcinoma. therapeutic application,unassigned 2,0 1.11.1.24 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34409853&form=6&db=m Membrane bound Peroxiredoxin-1 serves as a biomarker for in vivo detection of sessile serrated adenomas. diagnostic usage,therapeutic application,unassigned 3,2,0 1.11.1.24 Adenoma, Oxyphilic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22976689&form=6&db=m Adult rhabdomyoma with oncocytic changes affecting the floor of the mouth: optical, immunohistochemical, and ultrastructural study. causal interaction,unassigned 1,0 1.11.1.24 Adenoma, Pleomorphic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18992915&form=6&db=m Peroxiredoxin I, platelet-derived growth factor A, and platelet-derived growth factor receptor alpha are overexpressed in carcinoma ex pleomorphic adenoma: association with malignant transformation. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 1.11.1.24 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28659575&form=6&db=m Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 1.11.1.24 Adenoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29782637&form=6&db=m Luteolin ameliorates rat myocardial ischaemia-reperfusion injury through activation of peroxiredoxin II. therapeutic application,unassigned 1,0 1.11.1.24 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11771746&form=6&db=m Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 1.11.1.24 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17490890&form=6&db=m Interaction of amyloid binding alcohol dehydrogenase/Abeta mediates up-regulation of peroxiredoxin II in the brains of Alzheimer's disease patients and a transgenic Alzheimer's disease mouse model. causal interaction,ongoing research,unassigned 2,2,0 1.11.1.24 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22232637&form=6&db=m Peroxiredoxin I regulates the component expression of ?-secretase complex causing the Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 1.11.1.24 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29473507&form=6&db=m Oxidative Stress and Decreased Mitochondrial Superoxide Dismutase 2 and Peroxiredoxin 1 and 4 Based Mechanism of Concurrent Activation of AMPK and mTOR in Alzheimer's disease. causal interaction,unassigned 4,0 1.11.1.24 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9326351&form=6&db=m Calpromotin, a cytoplasmic protein, is associated with the formation of dense cells in sickle cell anemia. causal interaction,unassigned 4,0 1.11.1.24 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22960070&form=6&db=m Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 1.11.1.24 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26079888&form=6&db=m SOD1 deficiency induces the systemic hyperoxidation of peroxiredoxin in the mouse. causal interaction,unassigned 4,0 1.11.1.24 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33427524&form=6&db=m Erythrocytes as a preferential target of oxidative stress in blood. therapeutic application,unassigned 1,0 1.11.1.24 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33587325&form=6&db=m Active hematopoiesis triggers exosomal release of PRDX2 that promotes osteoclast formation. causal interaction,unassigned 1,0 1.11.1.24 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12586629&form=6&db=m Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice. causal interaction,therapeutic application,unassigned 4,3,0 1.11.1.24 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17105810&form=6&db=m Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte. therapeutic application,unassigned 1,0 1.11.1.24 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17990289&form=6&db=m Gene expression profiling related to the enhanced erythropoiesis in mouse bone marrow cells. ongoing research,therapeutic application,unassigned 2,1,0 1.11.1.24 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22960070&form=6&db=m Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 1.11.1.24 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23101509&form=6&db=m Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress. causal interaction,unassigned 4,0 1.11.1.24 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27677384&form=6&db=m Interactions between peroxiredoxin 2, hemichrome and the erythrocyte membrane. therapeutic application,unassigned 2,0 1.11.1.24 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30521599&form=6&db=m Global analysis of erythroid cells redox status reveals the involvement of Prdx1 and Prdx2 in the severity of beta thalassemia. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 1.11.1.24 Anemia, Hypochromic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22112219&form=6&db=m NTRC and Chloroplast-Generated Reactive Oxygen Species Regulate Pseudomonas syringae pv. tomato Disease Development in Tomato and Arabidopsis. causal interaction,ongoing research,unassigned 1,2,0 1.11.1.24 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9326351&form=6&db=m Calpromotin, a cytoplasmic protein, is associated with the formation of dense cells in sickle cell anemia. causal interaction,unassigned 4,0 1.11.1.24 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22960070&form=6&db=m Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 1.11.1.24 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24273028&form=6&db=m Immunoproteomically identified GBAA_0345, alkyl hydroperoxide reductase subunit C is a potential target for multivalent anthrax vaccine. therapeutic application,unassigned 3,0 1.11.1.24 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27612662&form=6&db=m S-nitrosylation of peroxiredoxin 1 contributes to viability of lung epithelial cells during Bacillus anthracis infection. diagnostic usage,ongoing research,unassigned 4,4,0 1.11.1.24 Aortic Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23525608&form=6&db=m Hyperhomocysteinemia during aortic aneurysm, a plausible role of epigenetics. causal interaction,ongoing research,unassigned 2,4,0 1.11.1.24 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21273562&form=6&db=m Identification of peroxiredoxin-1 as a novel biomarker of abdominal aortic aneurysm. causal interaction,therapeutic application,unassigned 2,3,0 1.11.1.24 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23241402&form=6&db=m Role of proinflammatory CD68(+) mannose receptor(-) macrophages in peroxiredoxin-1 expression and in abdominal aortic aneurysms in humans. causal interaction,unassigned 2,0 1.11.1.24 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32929220&form=6&db=m Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 Aortic Aneurysm, Thoracic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23525608&form=6&db=m Hyperhomocysteinemia during aortic aneurysm, a plausible role of epigenetics. causal interaction,ongoing research,unassigned 2,4,0 1.11.1.24 Arrhythmias, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7777418&form=6&db=m Programmable VT detection enhancements in implantable cardioverter defibrillator therapy. diagnostic usage,therapeutic application,unassigned 2,1,0 1.11.1.24 Arteritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17298582&form=6&db=m Vasculitis induced by immunization with Bacillus Calmette-Guérin followed by atypical mycobacterium antigen: a new mouse model for Kawasaki disease. causal interaction,therapeutic application,unassigned 2,4,0 1.11.1.24 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26211509&form=6&db=m Exacerbation of collagen antibody-induced arthritis in transgenic mice overexpressing peroxiredoxin 6. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.11.1.24 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15665454&form=6&db=m Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 1.11.1.24 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22565169&form=6&db=m Lymphocytes from rheumatoid arthritis patients have elevated levels of intracellular peroxiredoxin 2, and a greater frequency of cells with exofacial peroxiredoxin 2, compared with healthy human lymphocytes. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 1.11.1.24 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28323130&form=6&db=m Monocyte activation drives preservation of membrane thiols by promoting release of oxidised membrane moieties via extracellular vesicles. ongoing research,unassigned 3,0 1.11.1.24 Asthenozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25202954&form=6&db=m [Peroxiredoxin I in sperm and reactive oxygen species in seminal plasma in patients with idiopathic asthenozoospermia]. unassigned - 1.11.1.24 Asthenozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26585682&form=6&db=m TAT-peroxiredoxin 2 Fusion Protein Supplementation Improves Sperm Motility and DNA Integrity in Sperm Samples from Asthenozoospermic Men. therapeutic application,unassigned 4,0 1.11.1.24 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18442801&form=6&db=m Differential role of peroxiredoxin II (PrxII) on the expression of toll-like receptor 4 (TLR4) and B-cell activating factor (BAFF) in ovalbumin (OVA)-induced mouse asthma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 1.11.1.24 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19647805&form=6&db=m Peroxiredoxin I is a negative regulator of Th2-dominant allergic asthma. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 1.11.1.24 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22285837&form=6&db=m Hyperoxidized peroxiredoxins in peripheral blood mononuclear cells of asthma patients is associated with asthma severity. diagnostic usage,ongoing research,unassigned 2,3,0 1.11.1.24 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15952716&form=6&db=m Proteomic studies on low- and high-grade human brain astrocytomas. causal interaction,unassigned 3,0 1.11.1.24 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22985558&form=6&db=m [Expressions of peroxiredoxin 1, peroxiredoxin 6 and GFAP in human brain astrocytoma and their clinical significance]. diagnostic usage,ongoing research,unassigned 3,2,0 1.11.1.24 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25909245&form=6&db=m Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study. unassigned - 1.11.1.24 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21835911&form=6&db=m Peroxiredoxin 2 Deficiency Exacerbates Atherosclerosis in Apolipoprotein E-Deficient Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 1.11.1.24 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22548251&form=6&db=m Overexpression of peroxiredoxin 4 attenuates atherosclerosis in apolipoprotein e knockout mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 1.11.1.24 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23686369&form=6&db=m Deficiency of TDAG51 protects against atherosclerosis by modulating apoptosis, cholesterol efflux, and peroxiredoxin-1 expression. causal interaction,unassigned 3,0 1.11.1.24 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29341349&form=6&db=m Peroxiredoxin 4 (PRDX4): Its critical in vivo roles in animal models of metabolic syndrome ranging from atherosclerosis to nonalcoholic fatty liver disease. ongoing research,unassigned 2,0 1.11.1.24 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33791345&form=6&db=m PRDX2 Protects Against Atherosclerosis by Regulating the Phenotype and Function of the Vascular Smooth Muscle Cell. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 1.11.1.24 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15665454&form=6&db=m Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 1.11.1.24 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22003971&form=6&db=m A novel anti-peroxiredoxin autoantibody in patients with Kawasaki disease. causal interaction,diagnostic usage,unassigned 1,3,0 1.11.1.24 Babesiosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31189559&form=6&db=m Genome Editing of Babesia bovis Using the CRISPR/Cas9 System. unassigned - 1.11.1.24 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29277606&form=6&db=m Characterization of 2-Cys peroxiredoxin 3 and 4 in common carp and the immune response against bacterial infection. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 1.11.1.24 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31054357&form=6&db=m Molecular characterization and functional activity of Prx1 in grass carp (Ctenopharyngodon idella). causal interaction,unassigned 1,0 1.11.1.24 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31436131&form=6&db=m Elucidation of the AGR2 Interactome in Esophageal Adenocarcinoma Cells Identifies a Redox-Sensitive Chaperone Hub for the Quality Control of MUC-5AC. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 Behcet Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15665454&form=6&db=m Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 1.11.1.24 beta-Thalassemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24038029&form=6&db=m Thalassemic erythrocytes release microparticles loaded with hemichromes by redox activation of p72Syk kinase. unassigned - 1.11.1.24 beta-Thalassemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25564095&form=6&db=m Thalassemia major patients using iron chelators showed a reduced plasma thioredoxin level and reduced thioredoxin reductase activity, despite elevated oxidative stress. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 1.11.1.24 beta-Thalassemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30521599&form=6&db=m Global analysis of erythroid cells redox status reveals the involvement of Prdx1 and Prdx2 in the severity of beta thalassemia. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 1.11.1.24 Bone Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28391978&form=6&db=m Recombinant protein transduction domain-Cu/Zn superoxide dismutase alleviates bone cancer pain via peroxiredoxin 4 modulation and antioxidation. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 1.11.1.24 Bradycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8994946&form=6&db=m Initial single-center experience with an advanced third-generation investigational defibrillator. causal interaction,unassigned 1,0 1.11.1.24 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33129840&form=6&db=m Role of lipocalin-2 in extracellular peroxiredoxin 2-induced brain swelling, inflammation and neuronal death. ongoing research,unassigned 1,0 1.11.1.24 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29207618&form=6&db=m Neuroprotective effect of a novel gastrodin derivative against ischemic brain injury: involvement of peroxiredoxin and TLR4 signaling inhibition. causal interaction,therapeutic application,unassigned 4,4,0 1.11.1.24 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31273681&form=6&db=m Intracerebral Hemorrhage-Induced Brain Injury in Rats: the Role of Extracellular Peroxiredoxin 2. causal interaction,ongoing research,unassigned 1,2,0 1.11.1.24 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31399899&form=6&db=m Correction to: Intracerebral Hemorrhage-Induced Brain Injury in Rats: the Role of Extracellular Peroxiredoxin 2. ongoing research,unassigned 2,0 1.11.1.24 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29554978&form=6&db=m Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,2,0 1.11.1.24 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17663478&form=6&db=m Peroxiredoxin 2 overexpression protects cortical neuronal cultures from ischemic and oxidative injury but not glutamate excitotoxicity, whereas Cu/Zn superoxide dismutase 1 overexpression protects only against oxidative injury. ongoing research,therapeutic application,unassigned 3,1,0 1.11.1.24 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25955690&form=6&db=m Differences in the protein expression levels of Trx2 and Prx3 in the hippocampal CA1 region between adult and aged gerbils following transient global cerebral ischemia. unassigned - 1.11.1.24 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27333742&form=6&db=m [DAMPs (damage-associated molecular patterns) and inflammation]. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28871473&form=6&db=m Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells. causal interaction,therapeutic application,unassigned 3,1,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11469800&form=6&db=m Thioredoxin peroxidase-1 (peroxiredoxin-1) is increased in thioredoxin-1 transfected cells and results in enhanced protection against apoptosis caused by hydrogen peroxide but not by other agents including dexamethasone, etoposide, and doxorubicin. unassigned - 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11497302&form=6&db=m Overexpression of peroxiredoxin in human breast cancer. causal interaction,ongoing research,unassigned 2,4,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16288023&form=6&db=m The role of peroxiredoxin II in radiation-resistant MCF-7 breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17163455&form=6&db=m Peroxiredoxin I and II inhibit H2O2-induced cell death in MCF-7 cell lines. diagnostic usage,ongoing research,unassigned 1,4,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17265429&form=6&db=m Peroxiredoxin I and II inhibit H(2)O(2)-induced cell death in MCF-7 cell lines. ongoing research,unassigned 4,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17980029&form=6&db=m Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18272409&form=6&db=m Involvement of peroxiredoxin IV in the 16alpha-hydroxyestrone-induced proliferation of human MCF-7 breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19566940&form=6&db=m Overexpression of peroxiredoxin I and thioredoxin1 in human breast carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19584157&form=6&db=m Identification of a new panel of serum autoantibodies associated with the presence of in situ carcinoma of the breast in younger women. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20043069&form=6&db=m Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20541551&form=6&db=m The role of enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 in PP2-induced apoptosis in human breast cancer MCF-7 cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20631257&form=6&db=m Selective association of peroxiredoxin 1 with genomic DNA and COX-2 upstream promoter elements in estrogen receptor negative breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21423545&form=6&db=m Autoantibodies to tailor-made panels of tumor-associated antigens in breast carcinoma. diagnostic usage,therapeutic application,unassigned 1,1,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21475635&form=6&db=m Protein Signatures in Human MDA-MB-231 Breast Cancer Cells Indicating a More Invasive Phenotype Following Knockdown of Human Endometase/Matrilysin-2 by siRNA. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21641069&form=6&db=m Expression of thioredoxin system and related peroxiredoxin proteins is associated with clinical outcome in radiotherapy treated early stage breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21764677&form=6&db=m [Effect of peroxiredoxin I gene silencing on the radiosensitivity of breast carcinoma MCF-7 cell xenograft in nude mice]. ongoing research,therapeutic application,unassigned 4,1,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22020876&form=6&db=m GATA-binding protein 1 is a novel transcription regulator of peroxiredoxin 5 in human breast cancer cells. ongoing research,unassigned 3,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22430214&form=6&db=m Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23113308&form=6&db=m Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23758190&form=6&db=m Peroxiredoxin overexpression in MCF-7 breast cancer cells and regulation by cell proliferation and oxidative stress. ongoing research,unassigned 3,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24649208&form=6&db=m Peroxiredoxin V: A candidate breast tumor marker of population specificity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24789097&form=6&db=m Peroxiredoxin proteins protect MCF-7 breast cancer cells from doxorubicin-induced toxicity. ongoing research,unassigned 3,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24976757&form=6&db=m The role of peroxiredoxin II in chemoresistance of breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25011585&form=6&db=m Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer. causal interaction,therapeutic application,unassigned 1,1,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27503926&form=6&db=m SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29190947&form=6&db=m Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer. causal interaction,unassigned 3,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30287919&form=6&db=m Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents. ongoing research,unassigned 3,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31311441&form=6&db=m PRDX4 and Its Roles in Various Cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31412312&form=6&db=m Redox modifications of cysteine-containing proteins, cell cycle arrest and translation inhibition: Involvement in vitamin C-induced breast cancer cell death. diagnostic usage,unassigned 3,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31814764&form=6&db=m The Prognosis Of Peroxiredoxin Family In Breast Cancer. causal interaction,diagnostic usage,unassigned 3,4,0 1.11.1.24 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34389806&form=6&db=m Peroxiredoxin-1 Tyr194 phosphorylation regulates LOX-dependent extracellular matrix remodelling in breast cancer. causal interaction,ongoing research,unassigned 1,1,0 1.11.1.24 Brucellosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31196623&form=6&db=m Brucella infection regulates peroxiredoxin-5 protein expression to facilitate intracellular survival by reducing the production of nitric oxide and reactive oxygen species. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12507930&form=6&db=m Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate. causal interaction,therapeutic application,unassigned 3,1,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15882268&form=6&db=m Progression of secondary hyperparathyroidism involves deregulation of genes related to DNA and RNA stability. unassigned - 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16773180&form=6&db=m Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemoresistant tumors. unassigned - 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17084559&form=6&db=m p53 status is a major determinant of effects of decreasing peroxiredoxin I expression on tumor growth and response of lung cancer cells to treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17991311&form=6&db=m [Proteomic analysis of proteins related to radiation-induced carcinogenesis] causal interaction,diagnostic usage,unassigned 1,3,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19424615&form=6&db=m Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20043069&form=6&db=m Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20732753&form=6&db=m Role of peroxiredoxin I in rectal cancer and related to p53 status. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21119665&form=6&db=m Differential expression of ANXA6, HSP27, PRDX2, NCF2, and TPM4 during uterine cervix carcinogenesis: diagnostic and prognostic value. diagnostic usage,unassigned 2,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22475482&form=6&db=m Human peroxiredoxin 1 modulates TGF-?1-induced epithelial-mesenchymal transition through its peroxidase activity. causal interaction,unassigned 3,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23186333&form=6&db=m Prx I suppresses K-ras-driven lung tumorigenesis by opposing redox-sensitive ERK/cyclin D1 pathway. causal interaction,therapeutic application,unassigned 3,3,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24648924&form=6&db=m Peroxiredoxin 3 is a novel marker for cell proliferation in cervical cancer. diagnostic usage,ongoing research,unassigned 1,3,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24750185&form=6&db=m Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24862795&form=6&db=m Peroxiredoxin 2 expression is increased in neutrophils of patients with refractory cytopenia with multilineage dysplasia. causal interaction,unassigned 4,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24920174&form=6&db=m Overexpression of peroxiredoxin 2 inhibits TGF-?1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25275270&form=6&db=m Atrazine affects phosphoprotein and protein expression in MCF-10A human breast epithelial cells. therapeutic application,unassigned 1,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25579166&form=6&db=m Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma. causal interaction,therapeutic application,unassigned 1,1,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26500057&form=6&db=m Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signaling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27259998&form=6&db=m Peroxiredoxin 1 promotes invasion and migration by regulating epithelial-to-mesenchymal transition during oral carcinogenesis. unassigned - 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27517622&form=6&db=m Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis. causal interaction,ongoing research,unassigned 4,4,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27602166&form=6&db=m PRDX2 protects hepatocellular carcinoma SMMC-7721 cells from oxidative stress. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27966448&form=6&db=m Differential expression of peroxiredoxin 3 in laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28427494&form=6&db=m Characterization and Expression Analysis of Peroxiredoxin Genes in NNK-induced V79 Cells. ongoing research,unassigned 1,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28683851&form=6&db=m Survival of APC-mutant colorectal cancer cells requires interaction between tankyrase and a thiol peroxidase, peroxiredoxin II. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28712299&form=6&db=m Evaluation of Efficacy and Toxicity of Exfoliated Silicate Nanoclays as a Feed Additive for Fumonisin Detoxification. unassigned - 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31311441&form=6&db=m PRDX4 and Its Roles in Various Cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31536951&form=6&db=m PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31807984&form=6&db=m Prdx2 Upregulation Promotes the Growth and Survival of Gastric Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32908916&form=6&db=m PRDX2 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer In Vitro and In Vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32982301&form=6&db=m PRDX1 is a Tumor Suppressor for Nasopharyngeal Carcinoma by Inhibiting PI3K/AKT/TRAF1 Signaling. therapeutic application,unassigned 3,0 1.11.1.24 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34260286&form=6&db=m Peroxiredoxin 1 Interacts with TBK1/IKK? and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity. causal interaction,therapeutic application,unassigned 3,1,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10840156&form=6&db=m Peroxiredoxin I expression in oral cancer: a potential new tumor marker. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15239128&form=6&db=m Peroxiredoxins, a novel protein family in lung cancer. causal interaction,diagnostic usage,unassigned 4,4,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15955662&form=6&db=m Peroxiredoxin I expression in tongue squamous cell carcinomas as involved in tumor recurrence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15986332&form=6&db=m Comparative proteomic analysis of esophageal squamous cell carcinoma. diagnostic usage,ongoing research,unassigned 3,1,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16414373&form=6&db=m Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16781710&form=6&db=m Peroxiredoxin V is essential for protection against apoptosis in human lung carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17261093&form=6&db=m Proteomic analysis and characterisation of human cervico-vaginal fluid proteins. therapeutic application,unassigned 1,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18795324&form=6&db=m Angiogenesis in salivary carcinomas with and without myoepithelial differentiation. causal interaction,unassigned 2,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18992915&form=6&db=m Peroxiredoxin I, platelet-derived growth factor A, and platelet-derived growth factor receptor alpha are overexpressed in carcinoma ex pleomorphic adenoma: association with malignant transformation. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19251091&form=6&db=m Peroxiredoxin IV protects cells from radiation-induced apoptosis in head-and-neck squamous cell carcinoma. ongoing research,unassigned 3,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20450584&form=6&db=m [Proteomic identification and comparison of differentiation-related proteins in gastric carcinoma cell lines] diagnostic usage,therapeutic application,unassigned 1,1,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21434354&form=6&db=m [Effects of yiqi chutan recipe on tumor growth, survival time and expressions of PRDX-1 and PRDX-6 in Lewis lung carcinoma model mice with pi-deficiency syndrome]. ongoing research,unassigned 4,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21468086&form=6&db=m Silencing Prx1 and/or Prx5 sensitizes human esophageal cancer cells to ionizing radiation and increases apoptosis via intracellular ROS accumulation. diagnostic usage,ongoing research,unassigned 1,4,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22022930&form=6&db=m Downregulation of Peroxiredoxin I by a Novel Fully Human Phage Display Recombinant Antibody Induces Apoptosis and Enhances Radiation Sensitization in A549 Lung Carcinoma Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23113308&form=6&db=m Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23564483&form=6&db=m Peroxiredoxin III protein expression is associated with platinum resistance in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24009050&form=6&db=m Peroxiredoxin 1 is a tumor-associated antigen in esophageal squamous cell carcinoma. diagnostic usage,ongoing research,unassigned 1,3,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25162226&form=6&db=m Induction of peroxiredoxin 1 by hypoxia regulates heme oxygenase-1 via NF-?B in oral cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25579166&form=6&db=m Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma. causal interaction,therapeutic application,unassigned 1,1,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26261544&form=6&db=m Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26722077&form=6&db=m Loss of Peroxiredoxin Expression Is Associated with an Aggressive Phenotype in Pancreatic Adenocarcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26722300&form=6&db=m Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-?B in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27966448&form=6&db=m Differential expression of peroxiredoxin 3 in laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28293090&form=6&db=m Proteomic profiling of fetal esophageal epithelium, esophageal cancer, and tumor-adjacent esophageal epithelium and immunohistochemical characterization of a representative differential protein, PRX6. diagnostic usage,ongoing research,unassigned 3,3,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28391978&form=6&db=m Recombinant protein transduction domain-Cu/Zn superoxide dismutase alleviates bone cancer pain via peroxiredoxin 4 modulation and antioxidation. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28432271&form=6&db=m Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29088845&form=6&db=m Nicotine suppresses apoptosis by regulating ?7nAChR/Prx1 axis in oral precancerous lesions. unassigned - 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29180334&form=6&db=m [Quantitative and comparative proteomics analysis in clear cell renal cell carcinoma and adjacent noncancerous tissues by 2-D DIGE]. diagnostic usage,unassigned 3,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29228703&form=6&db=m Dual inhibition of BRD4 and PI3K-AKT by SF2523 suppresses human renal cell carcinoma cell growth. ongoing research,therapeutic application,unassigned 3,2,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29656298&form=6&db=m High Expression of Peroxiredoxin 1 Is Associated with Epithelial-Mesenchymal Transition Marker and Poor Prognosis in Gastric Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30657231&form=6&db=m REV7 confers radioresistance of esophagus squamous cell carcinoma by recruiting PRDX2. therapeutic application,unassigned 1,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31298537&form=6&db=m Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1. causal interaction,therapeutic application,unassigned 3,1,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31429766&form=6&db=m LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus. unassigned - 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32130676&form=6&db=m PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt/?-catenin and AKT pathways. ongoing research,unassigned 3,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33332365&form=6&db=m Peroxiredoxin 2 is highly expressed in human oral squamous cell carcinoma cells and is upregulated by human papillomavirus oncoproteins and arecoline, promoting proliferation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33969595&form=6&db=m Peroxiredoxin 5 is involved in cancer cell invasion and tumor growth of oral squamous cell carcinoma. causal interaction,ongoing research,unassigned 4,3,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34290530&form=6&db=m Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,3,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34512019&form=6&db=m Erratum: Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma [Corrigendum]. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0 1.11.1.24 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531683&form=6&db=m Erratum: Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma [Corrigendum]. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12530083&form=6&db=m Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16408314&form=6&db=m Increased oxidation and degradation of cytosolic proteins in alcohol-exposed mouse liver and hepatoma cells. causal interaction,unassigned 1,0 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17524271&form=6&db=m [The expression of peroxiredoxin II in hepatocellular carcinoma and its significance] causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19406930&form=6&db=m Peroxiredoxin I contributes to TRAIL resistance through suppression of redox-sensitive caspase activation in human hepatoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22344546&form=6&db=m Detection and identification of peroxiredoxin 3 as a biomarker in hepatocellular carcinoma by a proteomic approach. diagnostic usage,therapeutic application,unassigned 3,1,0 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22684688&form=6&db=m Measurement of peroxiredoxin-4 serum levels in rat tissue and its use as a potential marker for hepatic disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24297309&form=6&db=m Diagnostic and prognostic significance of peroxiredoxin 1 expression in human hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25188510&form=6&db=m Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells. causal interaction,therapeutic application,unassigned 1,1,0 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25339775&form=6&db=m Persistent hepatitis C virus infection impairs ribavirin antiviral activity through clathrin-mediated trafficking of equilibrative nucleoside transporter 1. causal interaction,therapeutic application,unassigned 1,1,0 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25743848&form=6&db=m Plasma nuclear factor kappa B and serum peroxiredoxin 3 in early diagnosis of hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 3,4,0 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26500057&form=6&db=m Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signaling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26866938&form=6&db=m Peroxiredoxin II is essential for maintaining stemness by redox regulation in liver cancer cells. diagnostic usage,ongoing research,unassigned 3,1,0 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27517622&form=6&db=m Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis. causal interaction,ongoing research,unassigned 4,4,0 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27602166&form=6&db=m PRDX2 protects hepatocellular carcinoma SMMC-7721 cells from oxidative stress. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29377617&form=6&db=m Peroxiredoxin 1, restraining cell migration and invasion, is involved in hepatocellular carcinoma recurrence. causal interaction,diagnostic usage,unassigned 4,3,0 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29687726&form=6&db=m The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31256347&form=6&db=m Peroxiredoxin 4 suppresses anoikis and augments growth and metastasis of hepatocellular carcinoma cells through the ?-catenin/ID2 pathway. causal interaction,therapeutic application,unassigned 3,1,0 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31500275&form=6&db=m Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 1.11.1.24 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34428517&form=6&db=m Peroxiredoxin 1 is essential for natamycin-triggered apoptosis and protective autophagy in hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 1.11.1.24 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21434354&form=6&db=m [Effects of yiqi chutan recipe on tumor growth, survival time and expressions of PRDX-1 and PRDX-6 in Lewis lung carcinoma model mice with pi-deficiency syndrome]. ongoing research,unassigned 4,0 1.11.1.24 Carcinoma, Mucoepidermoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18795324&form=6&db=m Angiogenesis in salivary carcinomas with and without myoepithelial differentiation. causal interaction,unassigned 2,0 1.11.1.24 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17606720&form=6&db=m Elevated peroxiredoxin 1, but not NF-E2-related factor 2, is an independent prognostic factor for disease recurrence and reduced survival in stage I non-small cell lung cancer. causal interaction,diagnostic usage,unassigned 3,4,0 1.11.1.24 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26261544&form=6&db=m Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 1.11.1.24 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32232956&form=6&db=m Proteomic and genomic biomarkers for Non-Small Cell Lung Cancer: Peroxiredoxin, Haptoglobin, and Alpha-1 antitrypsin. diagnostic usage,therapeutic application,unassigned 1,1,0 1.11.1.24 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32337219&form=6&db=m Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells. causal interaction,ongoing research,unassigned 1,2,0 1.11.1.24 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32908916&form=6&db=m PRDX2 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer In Vitro and In Vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 1.11.1.24 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23564483&form=6&db=m Peroxiredoxin III protein expression is associated with platinum resistance in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.11.1.24 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10530780&form=6&db=m Peroxiredoxin I expression in human thyroid tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.11.1.24 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16725008&form=6&db=m Oxidative/nitrosative stress and peroxiredoxin 2 are associated with grade and prognosis of human renal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 1.11.1.24 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29180334&form=6&db=m [Quantitative and comparative proteomics analysis in clear cell renal cell carcinoma and adjacent noncancerous tissues by 2-D DIGE]. diagnostic usage,unassigned 3,0 1.11.1.24 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29228703&form=6&db=m Dual inhibition of BRD4 and PI3K-AKT by SF2523 suppresses human renal cell carcinoma cell growth. ongoing research,therapeutic application,unassigned 3,2,0 1.11.1.24 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15239128&form=6&db=m Peroxiredoxins, a novel protein family in lung cancer. causal interaction,diagnostic usage,unassigned 4,4,0 1.11.1.24 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15955662&form=6&db=m Peroxiredoxin I expression in tongue squamous cell carcinomas as involved in tumor recurrence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.11.1.24 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15986332&form=6&db=m Comparative proteomic analysis of esophageal squamous cell carcinoma. diagnostic usage,ongoing research,unassigned 3,1,0 1.11.1.24 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17261093&form=6&db=m Proteomic analysis and characterisation of human cervico-vaginal fluid proteins. therapeutic application,unassigned 1,0 1.11.1.24 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19251091&form=6&db=m Peroxiredoxin IV protects cells from radiation-induced apoptosis in head-and-neck squamous cell carcinoma. ongoing research,unassigned 3,0 1.11.1.24 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26261544&form=6&db=m Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 1.11.1.24 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30657231&form=6&db=m REV7 confers radioresistance of esophagus squamous cell carcinoma by recruiting PRDX2. therapeutic application,unassigned 1,0 1.11.1.24 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31429766&form=6&db=m LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus. unassigned - 1.11.1.24 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31470801&form=6&db=m Expression of thioredoxin 1 and peroxiredoxins in squamous cervical carcinoma and its predictive role in NACT. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 1.11.1.24 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31920397&form=6&db=m Silencing of Peroxiredoxin 1 Inhibits the Proliferation of Esophageal Cancer Cells and Promotes Apoptosis by Inhibiting the Activity of the PI3K/AKT Pathway. ongoing research,therapeutic application,unassigned 4,1,0 1.11.1.24 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29036266&form=6&db=m Alterations in NO/ROS ratio and expression of Trx1 and Prdx2 in isoproterenol-induced cardiac hypertrophy. causal interaction,unassigned 4,0 1.11.1.24 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32531679&form=6&db=m Peroxiredoxin-1 ameliorates pressure overload-induced cardiac hypertrophy and fibrosis. unassigned - 1.11.1.24 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29438398&form=6&db=m Proteomics analysis identified peroxiredoxin 2 involved in early-phase left ventricular impairment in hamsters with cardiomyopathy. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 1.11.1.24 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31934725&form=6&db=m (Letter to the Editor) Response to: protective role of peroxiredoxin-4 in heart failure. ongoing research,therapeutic application,unassigned 1,1,0 1.11.1.24 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26573464&form=6&db=m Hydrogen sulfide attenuates doxorubicin-induced cardiotoxicity by inhibiting the expression of peroxiredoxin III in H9c2 cells. therapeutic application,unassigned 1,0 1.11.1.24 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32516552&form=6&db=m Galectin-3 inhibition attenuates doxorubicin-induced cardiac dysfunction by upregulating the expression of peroxiredoxin-4. causal interaction,therapeutic application,unassigned 2,2,0 1.11.1.24 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32802259&form=6&db=m Peroxiredoxin-1 Overexpression Attenuates Doxorubicin-Induced Cardiotoxicity by Inhibiting Oxidative Stress and Cardiomyocyte Apoptosis. causal interaction,therapeutic application,unassigned 4,2,0 1.11.1.24 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15902258&form=6&db=m Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. causal interaction,therapeutic application,unassigned 4,4,0 1.11.1.24 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18166010&form=6&db=m The left ventricle proteome differentiates middle-aged and old left ventricles in mice. causal interaction,unassigned 1,0 1.11.1.24 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23316297&form=6&db=m Peroxiredoxin 4, a novel circulating biomarker for oxidative stress and the risk of incident cardiovascular disease and all-cause mortality. causal interaction,therapeutic application,unassigned 3,3,0 1.11.1.24 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16360653&form=6&db=m Reduced expression of 1-cys peroxiredoxin in oxidative stress-induced cataracts. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 1.11.1.24 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17893648&form=6&db=m Localization and H2O2-specific induction of PRDX3 in the eye lens. causal interaction,unassigned 4,0 1.11.1.24 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27821296&form=6&db=m Peroxiredoxin 1-mediated activation of TLR4/NF-?B pathway contributes to neuroinflammatory injury in intracerebral hemorrhage. causal interaction,unassigned 2,0 1.11.1.24 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27924073&form=6&db=m Diagnostic performance of peroxiredoxin 1 to determine time-of-onset of acute cerebral infarction. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 1.11.1.24 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34417212&form=6&db=m Identifying patients with cerebral infarction within the time window compatible with reperfusion therapy, diagnostic performance of glutathione S-transferase-? (GST-?) and peroxiredoxin 1 (PRDX1): exploratory prospective multicentre study FLAG-1 protocol. therapeutic application,unassigned 2,0 1.11.1.24 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22446018&form=6&db=m Prognostic significance of peroxiredoxin 1 and ezrin-radixin-moesin-binding phosphoprotein 50 in cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 1.11.1.24 Cholesteatoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23852020&form=6&db=m Upregulation of phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in acquired middle ear cholesteatoma growth. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 Cholesteatoma, Middle Ear http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23852020&form=6&db=m Upregulation of phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in acquired middle ear cholesteatoma growth. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30824188&form=6&db=m SF2523 inhibits human chondrosarcoma cell growth in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 1.11.1.24 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24048895&form=6&db=m Ablation of Peroxiredoxin II Attenuates Experimental Colitis by Increasing FoxO1-Induced Foxp3+ Regulatory T Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.11.1.24 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24743300&form=6&db=m Attenuation of experimental colitis in glutathione peroxidase 1 and catalase double knockout mice through enhancing regulatory T cell function. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 1.11.1.24 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33158023&form=6&db=m Sigma-1 Receptor Engages an Anti-Inflammatory and Antioxidant Feedback Loop Mediated by Peroxiredoxin in Experimental Colitis. ongoing research,therapeutic application,unassigned 2,2,0 1.11.1.24 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11169225&form=6&db=m Elevated antibody responses in patients with Crohn's disease against a 14-kDa secreted protein purified from Mycobacterium avium subsp. paratuberculosis. diagnostic usage,unassigned 3,0 1.11.1.24 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29434945&form=6&db=m Peroxiredoxin 1 expression in active ulcerative colitis mucosa identified by proteome analysis and involvement of thioredoxin based on immunohistochemistry. diagnostic usage,ongoing research,unassigned 2,3,0 1.11.1.24 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33682513&form=6&db=m Silencing of peroxiredoxin 1 expression ameliorates ulcerative colitis in a rat model. ongoing research,unassigned 4,0 1.11.1.24 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27894099&form=6&db=m Peroxiredoxin 2 is essential for maintaining cancer stem cell-like phenotype through activation of Hedgehog signaling pathway in colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 1.11.1.24 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28431931&form=6&db=m Peroxiredoxin 5 promotes the epithelial-mesenchymal transition in colon cancer. unassigned - 1.11.1.24 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28432271&form=6&db=m Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.11.1.24 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29802121&form=6&db=m Telomerase can't handle the stress. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 1.11.1.24 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31262894&form=6&db=m Peroxiredoxin V Reduces ?-Lapachone-induced Apoptosis of Colon Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.11.1.24 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31388312&form=6&db=m siPRDX2-elevated DNM3 inhibits the proliferation and metastasis of colon cancer cells via AKT signaling pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 1.11.1.24 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31704839&form=6&db=m Shikonin-induced Apoptosis of Colon Cancer Cells Is Reduced by Peroxiredoxin V Expression. ongoing research,therapeutic application,unassigned 4,1,0 1.11.1.24 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33819194&form=6&db=m The critical role of peroxiredoxin-2 in colon cancer stem cells. causal interaction,unassigned 2,0 1.11.1.24 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23393224&form=6&db=m Prognostic role of serum AZGP1, PEDF and PRDX2 in colorectal cancer patients. causal interaction,diagnostic usage,unassigned 3,3,0 1.11.1.24 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24125860&form=6&db=m Peroxiredoxin 2 knockdown by RNA interference inhibits the growth of colorectal cancer cells by downregulating Wnt/?-catenin signaling. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 1.11.1.24 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24234423&form=6&db=m Peroxiredoxin 2 is upregulated in colorectal cancer and contributes to colorectal cancer cells' survival by protecting cells from oxidative stress. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 1.11.1.24 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24920174&form=6&db=m Overexpression of peroxiredoxin 2 inhibits TGF-?1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 1.11.1.24 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25054044&form=6&db=m High expression of peroxiredoxin 4 affects the survival time of colorectal cancer patients, but is not an independent unfavorable prognostic factor. diagnostic usage,unassigned 4,0 1.11.1.24 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25471788&form=6&db=m Peroxiredoxin 2 is involved in vasculogenic mimicry formation by targeting VEGFR2 activation in colorectal cancer. ongoing research,unassigned 4,0 1.11.1.24 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27894099&form=6&db=m Peroxiredoxin 2 is essential for maintaining cancer stem cell-like phenotype through activation of Hedgehog signaling pathway in colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 1.11.1.24 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28125800&form=6&db=m Peroxiredoxin 2 is associated with colorectal cancer progression and poor survival of patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28659575&form=6&db=m Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 1.11.1.24 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28683851&form=6&db=m Survival of APC-mutant colorectal cancer cells requires interaction between tankyrase and a thiol peroxidase, peroxiredoxin II. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 1.11.1.24 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29673884&form=6&db=m Peroxiredoxin 1 promoted tumor metastasis and angiogenesis in colorectal cancer. causal interaction,diagnostic usage,unassigned 4,3,0 1.11.1.24 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29691673&form=6&db=m Multi-panel assay of serum autoantibodies in colorectal cancer. diagnostic usage,ongoing research,unassigned 3,2,0 1.11.1.24 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31311441&form=6&db=m PRDX4 and Its Roles in Various Cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 1.11.1.24 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32692719&form=6&db=m PRDX2 removal inhibits the cell cycle and autophagy in colorectal cancer cells. diagnostic usage,ongoing research,unassigned 1,3,0 1.11.1.24 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34117220&form=6&db=m PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.11.1.24 Corneal Dystrophies, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34369396&form=6&db=m Confirmation of PRDX3 c.568G>C as the Genetic Basis of Punctiform and Polychromatic Pre-Descemet Corneal Dystrophy. unassigned - 1.11.1.24 Corneal Dystrophies, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34403298&form=6&db=m Torin 1 alleviates impairment of TFEB-mediated lysosomal biogenesis and autophagy in TGFBI (p.G623_H626del)-linked Thiel-Behnke corneal dystrophy. causal interaction,unassigned 2,0 1.11.1.24 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28575568&form=6&db=m [Concentration of proinflammatory cytokines, peroxiredoxin-1 and glutathione peroxidase activity in the blood plasma of patients with coronary artery disease undergoing coronary artery bypass grafting]. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 1.11.1.24 Coronary Occlusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32016473&form=6&db=m Hyperbaric oxygenation improves redox control and reduces mortality in the acute phase of myocardial infarction in a rat model. diagnostic usage,ongoing research,unassigned 3,1,0 1.11.1.24 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33688653&form=6&db=m Blockade of SARS-CoV-2 infection in vitro by highly potent PI3K-?/mTOR/BRD4 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0 1.11.1.24 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11169225&form=6&db=m Elevated antibody responses in patients with Crohn's disease against a 14-kDa secreted protein purified from Mycobacterium avium subsp. paratuberculosis. diagnostic usage,unassigned 3,0 1.11.1.24 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22497500&form=6&db=m Molecular cloning reveals nearly half of patients with Crohn's disease have an antibody to peroxiredoxin 6-like protein. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,1,1 1.11.1.24 Cryptorchidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12688509&form=6&db=m Impaired expression of peroxiredoxin 4 in damaged testes by artificial cryptorchidism. unassigned - 1.11.1.24 Cysticercosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18393902&form=6&db=m Taenia solium: antioxidant metabolism enzymes as targets for cestocidal drugs and vaccines. therapeutic application,unassigned 2,0 1.11.1.24 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11087915&form=6&db=m Cloning, expression and functional characterisation of a peroxiredoxin from the potato cyst nematode Globodera rostochiensis. ongoing research,unassigned 4,0 1.11.1.24 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31417643&form=6&db=m Quantitative Proteomic Analysis and Evaluation of the Potential Prognostic Biomarkers in Cholangiocarcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.11.1.24 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32564961&form=6&db=m Decreased Expression of Peroxiredoxin in Patients with Ovarian Endometriosis Cysts. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 1.11.1.24 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19323035&form=6&db=m Differential expression of aldolase, alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from dengue fever and dengue hemorrhagic fever patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 1.11.1.24 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15821833&form=6&db=m Hyperhomocysteinemic diabetic cardiomyopathy: oxidative stress, remodeling, and endothelial-myocyte uncoupling. causal interaction,therapeutic application,unassigned 3,1,0 1.11.1.24 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18082151&form=6&db=m Proteomic analysis of mouse islets after multiple low-dose streptozotocin injection. diagnostic usage,therapeutic application,unassigned 2,1,0 1.11.1.24 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24586984&form=6&db=m Serum peroxiredoxin 4: a marker of oxidative stress associated with mortality in type 2 diabetes (ZODIAC-28). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1 1.11.1.24 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25742636&form=6&db=m Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus. causal interaction,diagnostic usage,unassigned 3,2,0 1.11.1.24 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18082151&form=6&db=m Proteomic analysis of mouse islets after multiple low-dose streptozotocin injection. diagnostic usage,therapeutic application,unassigned 2,1,0 1.11.1.24 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20807727&form=6&db=m Peroxiredoxin III protects pancreatic {beta} cells from apoptosis. ongoing research,therapeutic application,unassigned 1,3,0 1.11.1.24 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22160369&form=6&db=m Training increases peroxiredoxin 2 contents in the erythrocytes of overweight/obese men suffering from type 2 diabetes. ongoing research,unassigned 3,0 1.11.1.24 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23477499&form=6&db=m PEROXIREDOXIN 4 PROTECTS AGAINST NONALCOHOLIC STEATOHEPATITIS AND TYPE 2 DIABETES IN A NONGENETIC MOUSE MODEL. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 1.11.1.24 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24254933&form=6&db=m Expression of hepatic antioxidant enzymes in non-obese type-2 diabetic Goto-Kakizaki rats. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24586984&form=6&db=m Serum peroxiredoxin 4: a marker of oxidative stress associated with mortality in type 2 diabetes (ZODIAC-28). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1 1.11.1.24 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24893865&form=6&db=m Circulating peroxiredoxin 4 and type 2 diabetes risk: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study. ongoing research,therapeutic application,unassigned 3,1,0 1.11.1.24 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25742636&form=6&db=m Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus. causal interaction,diagnostic usage,unassigned 3,2,0 1.11.1.24 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27393003&form=6&db=m Mitochondrial Peroxiredoxin-3 protects against hyperglycemia induced myocardial damage in Diabetic cardiomyopathy. causal interaction,unassigned 3,0 1.11.1.24 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32739204&form=6&db=m Decoy receptor 2 mediation of the senescent phenotype of tubular cells by interacting with peroxiredoxin 1 presents a novel mechanism of renal fibrosis in diabetic nephropathy. causal interaction,unassigned 3,0 1.11.1.24 dimethylargininase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28594240&form=6&db=m Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice. causal interaction,ongoing research,unassigned 4,4,0 1.11.1.24 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11771746&form=6&db=m Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 1.11.1.24 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12943237&form=6&db=m Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, is under-expressed in Down syndrome fetal brains. ongoing research,unassigned 3,0 1.11.1.24 Drug Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33672092&form=6&db=m Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions. ongoing research,unassigned 1,0 1.11.1.24 Dry Eye Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26287192&form=6&db=m Antigen-Antibody Affinity for Dry Eye Biomarkers by Label Free Biosensing. Comparison with the ELISA Technique. diagnostic usage,unassigned 1,0 1.11.1.24 Dysentery, Amebic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16968225&form=6&db=m Comparative proteomic analysis of two Entamoeba histolytica strains with different virulence phenotypes identifies peroxiredoxin as an important component of amoebic virulence. causal interaction,unassigned 4,0 1.11.1.24 Echinococcosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14729274&form=6&db=m Functional expression and characterization of Echinococcus granulosus thioredoxin peroxidase suggests a role in protection against oxidative damage. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.11.1.24 Echinococcosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18060722&form=6&db=m Thioredoxin peroxidase from Echinococcus granulosus: a candidate to extend the antigenic panel for the immunodiagnosis of human cystic echinococcosis. ongoing research,unassigned 1,0 1.11.1.24 Echinococcosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32426296&form=6&db=m Preliminary Evaluation of Recombinant EPC1 and TPx for Serological Diagnosis of Animal Cystic Echinococcosis. diagnostic usage,therapeutic application,unassigned 2,4,0 1.11.1.24 Elephantiasis, Filarial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19190232&form=6&db=m Evaluation of immunoprophylactic efficacy of Brugia malayi transglutaminase (BmTGA) in single and multiple antigen vaccination with BmALT-2 and BmTPX for human lymphatic filariasis. ongoing research,therapeutic application,unassigned 1,4,0 1.11.1.24 Elephantiasis, Filarial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21288496&form=6&db=m Proliferative responses of Brugia malayi TPX-1 and its epitopic peptide(29-43) in an endemic population of human lymphatic filariasis. ongoing research,therapeutic application,unassigned 1,1,0 1.11.1.24 Elephantiasis, Filarial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22528648&form=6&db=m Brugia malayi thioredoxin peroxidase as a potential vaccine candidate antigen for lymphatic filariasis. diagnostic usage,therapeutic application,unassigned 1,3,0 1.11.1.24 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22783432&form=6&db=m Expression and prognostic significance of human peroxiredoxin isoforms in endometrial cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 1.11.1.24 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22783432&form=6&db=m Expression and prognostic significance of human peroxiredoxin isoforms in endometrial cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 1.11.1.24 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29190956&form=6&db=m Peroxiredoxin 3 maintains the survival of endometrial cancer stem cells by regulating oxidative stress. unassigned - 1.11.1.24 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29541251&form=6&db=m Overexpression of peroxiredoxin-3 and -5 is a potential biomarker for prognosis in endometrial cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 1.11.1.24 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17124717&form=6&db=m An investigation of the effects of endometriosis on the proteome of human eutopic endometrium: a heterogeneous tissue with a complex disease. causal interaction,diagnostic usage,unassigned 2,1,0 1.11.1.24 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22843871&form=6&db=m Down-regulation of 8-Hydroxydeoxyguanosine and Peroxiredoxin II in the Pathogenesis of Endometriosis-associated Ovarian Cancer. diagnostic usage,ongoing research,unassigned 1,2,0 1.11.1.24 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32564961&form=6&db=m Decreased Expression of Peroxiredoxin in Patients with Ovarian Endometriosis Cysts. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 1.11.1.24 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21468086&form=6&db=m Silencing Prx1 and/or Prx5 sensitizes human esophageal cancer cells to ionizing radiation and increases apoptosis via intracellular ROS accumulation. diagnostic usage,ongoing research,unassigned 1,4,0 1.11.1.24 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22215146&form=6&db=m Polymorphisms of peroxiredoxin 1, 2 and 6 are not associated with esophageal cancer. causal interaction,therapeutic application,unassigned 3,1,0 1.11.1.24 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27650197&form=6&db=m Pro-Apoptotic Effects of JDA-202, a Novel Natural Diterpenoid, on Esophageal Cancer Through Targeting Peroxiredoxin I. ongoing research,unassigned 2,0 1.11.1.24 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28293090&form=6&db=m Proteomic profiling of fetal esophageal epithelium, esophageal cancer, and tumor-adjacent esophageal epithelium and immunohistochemical characterization of a representative differential protein, PRX6. diagnostic usage,ongoing research,unassigned 3,3,0 1.11.1.24 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31920397&form=6&db=m Silencing of Peroxiredoxin 1 Inhibits the Proliferation of Esophageal Cancer Cells and Promotes Apoptosis by Inhibiting the Activity of the PI3K/AKT Pathway. ongoing research,therapeutic application,unassigned 4,1,0 1.11.1.24 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24009050&form=6&db=m Peroxiredoxin 1 is a tumor-associated antigen in esophageal squamous cell carcinoma. diagnostic usage,ongoing research,unassigned 1,3,0 1.11.1.24 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25579166&form=6&db=m Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma. causal interaction,therapeutic application,unassigned 1,1,0 1.11.1.24 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32130676&form=6&db=m PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt/?-catenin and AKT pathways. ongoing research,unassigned 3,0 1.11.1.24 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17060495&form=6&db=m Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia. unassigned - 1.11.1.24 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23200777&form=6&db=m Liver proteomics in progressive alcoholic steatosis. diagnostic usage,unassigned 4,0 1.11.1.24 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31505325&form=6&db=m Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling. causal interaction,therapeutic application,unassigned 1,1,0 1.11.1.24 Fatty Liver, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33249138&form=6&db=m The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver. diagnostic usage,ongoing research,unassigned 2,3,0 1.11.1.24 Fetal Alcohol Spectrum Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14691149&form=6&db=m Catalase and peroxiredoxin 5 protect Xenopus embryos against alcohol-induced ocular anomalies. unassigned - 1.11.1.24 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29908016&form=6&db=m Peroxiredoxin 1 (PRDX1) Suppresses Progressions and Metastasis of Osteosarcoma and Fibrosarcoma of Bone. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 Fuchs' Endothelial Dystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18378575&form=6&db=m Decreased expression of peroxiredoxins in Fuchs' endothelial dystrophy. ongoing research,unassigned 4,0 1.11.1.24 Gallstones http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25671835&form=6&db=m Identification of cholesterol gallstone with two-dimensional gel electrophoresis and mass spectrometry. diagnostic usage,unassigned 4,0 1.11.1.24 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19108621&form=6&db=m Production of polyclonal antibody against alkyl hydroperoxide reductase of Helicobacter pylori and its antigenicity. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 1.11.1.24 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24750185&form=6&db=m Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 1.11.1.24 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33917763&form=6&db=m Genetic Inactivation of Peroxiredoxin-I Impairs the Growth of Human Pancreatic Cancer Cells. causal interaction,unassigned 4,0 1.11.1.24 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32339330&form=6&db=m PCAT6 mediates cellular biological functions in gastrointestinal stromal tumor via upregulation of PRDX5 and activation of Wnt pathway. causal interaction,unassigned 2,0 1.11.1.24 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15952716&form=6&db=m Proteomic studies on low- and high-grade human brain astrocytomas. causal interaction,unassigned 3,0 1.11.1.24 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17233837&form=6&db=m Biomarker discovery: a proteomic approach for brain cancer profiling. unassigned - 1.11.1.24 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22916164&form=6&db=m Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth. causal interaction,ongoing research,unassigned 3,3,0 1.11.1.24 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24976757&form=6&db=m The role of peroxiredoxin II in chemoresistance of breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 1.11.1.24 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28351321&form=6&db=m Mammalian target of rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by phorbol-myristate-acetate and oncostatin-M in glioblastoma cells. ongoing research,unassigned 1,0 1.11.1.24 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28461233&form=6&db=m Inhibition of reductase systems by 2-AAPA modulates peroxiredoxin oxidation and mitochondrial function in A172 glioblastoma cells. therapeutic application,unassigned 1,0 1.11.1.24 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32265299&form=6&db=m High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11). causal interaction,ongoing research,unassigned 4,2,0 1.11.1.24 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18718523&form=6&db=m Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H(2)O(2). causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22158042&form=6&db=m Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro. ongoing research,unassigned 4,0 1.11.1.24 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24879047&form=6&db=m Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells. causal interaction,therapeutic application,unassigned 1,3,0 1.11.1.24 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24976757&form=6&db=m The role of peroxiredoxin II in chemoresistance of breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 1.11.1.24 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25484280&form=6&db=m Redox proteomics reveal stress responsive proteins linking peroxiredoxin-1 status in glioma to chemosensitivity and oxidative stress. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 1.11.1.24 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28481733&form=6&db=m Tissue Proteome Analysis of Different Grades of Human Gliomas Provides Major Cues for Glioma Pathogenesis. diagnostic usage,ongoing research,unassigned 1,2,0 1.11.1.24 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33747176&form=6&db=m MicroRNA-383 promotes reactive oxygen species-induced autophagy via downregulating peroxiredoxin 3 in human glioma U87 cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 1.11.1.24 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34386062&form=6&db=m lnc-NLC1-C inhibits migration, invasion and autophagy of glioma cells by targeting miR-383 and regulating PRDX-3 expression. ongoing research,unassigned 1,0 1.11.1.24 Goiter http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15785239&form=6&db=m Peroxiredoxin 5 expression in the human thyroid gland. diagnostic usage,ongoing research,unassigned 4,4,0 1.11.1.24 Graves Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10530780&form=6&db=m Peroxiredoxin I expression in human thyroid tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.11.1.24 Graves Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15785239&form=6&db=m Peroxiredoxin 5 expression in the human thyroid gland. diagnostic usage,ongoing research,unassigned 4,4,0 1.11.1.24 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24976757&form=6&db=m The role of peroxiredoxin II in chemoresistance of breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 1.11.1.24 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23626763&form=6&db=m Mitochondrial peroxiredoxin 3 regulates sensory cell survival in the cochlea. causal interaction,therapeutic application,unassigned 1,3,0 1.11.1.24 Hearing Loss, Sensorineural http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33749526&form=6&db=m PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage. therapeutic application,unassigned 1,0 1.11.1.24 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24617620&form=6&db=m CT-proAVP (copeptin), MR-proANP and Peroxiredoxin 4 after cardiac arrest: release profiles and correlation to outcome. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 1.11.1.24 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18922030&form=6&db=m Proteomic analysis of left ventricular remodeling in an experimental model of heart failure. ongoing research,unassigned 1,0 1.11.1.24 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31934724&form=6&db=m Protective role of peroxiredoxin-4 in heart failure. causal interaction,therapeutic application,unassigned 1,1,0 1.11.1.24 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31934725&form=6&db=m (Letter to the Editor) Response to: protective role of peroxiredoxin-4 in heart failure. ongoing research,therapeutic application,unassigned 1,1,0 1.11.1.24 Hemangiosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12963914&form=6&db=m Expression of peroxiredoxin II in vascular tumors of the skin: a novel vascular marker of endothelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.11.1.24 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16342242&form=6&db=m Proteome analysis of hepatocellular carcinoma by laser capture microdissection. causal interaction,diagnostic usage,unassigned 2,4,0 1.11.1.24 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17586277&form=6&db=m Laser capture microdissection in comparative proteomic analysis of hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 2,3,0 1.11.1.24 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20939925&form=6&db=m Peroxiredoxin 2: a potential biomarker for early diagnosis of hepatitis B virus related liver fibrosis identified by proteomic analysis of the plasma. causal interaction,diagnostic usage,unassigned 4,4,0 1.11.1.24 Hepatoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32655804&form=6&db=m Peroxiredoxin 4 promotes embryonal hepatoblastoma cell migration but induces fetal cell differentiation. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 1.11.1.24 Hepatolenticular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22684688&form=6&db=m Measurement of peroxiredoxin-4 serum levels in rat tissue and its use as a potential marker for hepatic disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 1.11.1.24 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27268288&form=6&db=m Identification of differentially expressed reproductive and metabolic proteins in the female abalone (Haliotis laevigata) gonad following artificial induction of spawning. unassigned - 1.11.1.24 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31256343&form=6&db=m Imbalanced testicular metabolism induced by thyroid disorders: New evidences from quantitative proteome. diagnostic usage,unassigned 3,0 1.11.1.24 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12421812&form=6&db=m HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family. therapeutic application,unassigned 2,0 1.11.1.24 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24904103&form=6&db=m The PRDX2 gene is transcriptionally silenced and de novo methylated in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma. ongoing research,unassigned 1,0 1.11.1.24 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25236407&form=6&db=m Differential protein expression of peroxiredoxin-1 in classical Hodgkin Lymphoma: a possible correlation to clinical behaviour. diagnostic usage,ongoing research,unassigned 2,2,0 1.11.1.24 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31500275&form=6&db=m Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 1.11.1.24 Hydronephrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24188713&form=6&db=m Peroxiredoxin I protein, a potential biomarker of hydronephrosis in fetal mice exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 1.11.1.24 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28391978&form=6&db=m Recombinant protein transduction domain-Cu/Zn superoxide dismutase alleviates bone cancer pain via peroxiredoxin 4 modulation and antioxidation. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 1.11.1.24 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25454523&form=6&db=m Changes in mouse liver and chicken embryo yolk sac membrane soluble proteins due to an organophosphorous insecticide (OPI) diazinon linked to several noncholinergic OPI effects in mice and chicken embryos. unassigned - 1.11.1.24 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27393003&form=6&db=m Mitochondrial Peroxiredoxin-3 protects against hyperglycemia induced myocardial damage in Diabetic cardiomyopathy. causal interaction,unassigned 3,0 1.11.1.24 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24496069&form=6&db=m Hyperhomocysteinemia and Bleomycin Hydrolase Modulate the Expression of Mouse Brain Proteins Involved in Neurodegeneration. unassigned - 1.11.1.24 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21118936&form=6&db=m Humoral and in vivo cellular immunity against the raw insect-derived recombinant Leishmania infantum antigens KMPII, TRYP, LACK, and papLe22 in dogs from an endemic area. ongoing research,therapeutic application,unassigned 1,2,0 1.11.1.24 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17556052&form=6&db=m Analysis of peroxiredoxin decreasing oxidative stress in hypertensive aortic smooth muscle. ongoing research,unassigned 4,0 1.11.1.24 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19135993&form=6&db=m S 35171 exerts protective effects in spontaneously hypertensive stroke-prone rats by preserving mitochondrial function. causal interaction,unassigned 1,0 1.11.1.24 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30980996&form=6&db=m Peroxiredoxin 4 levels in patients with PCOS and/or obesity. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 1.11.1.24 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15785239&form=6&db=m Peroxiredoxin 5 expression in the human thyroid gland. diagnostic usage,ongoing research,unassigned 4,4,0 1.11.1.24 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20729758&form=6&db=m Redox Regulation of Myocardial ERK 1/2 Phosphorylation in Experimental Hyperthyroidism: Role of Thioredoxin - Peroxiredoxin System. causal interaction,unassigned 3,0 1.11.1.24 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12373774&form=6&db=m Bronchoalveolar lavage fluid protein composition in patients with sarcoidosis and idiopathic pulmonary fibrosis: a two-dimensional electrophoretic study. causal interaction,unassigned 3,0 1.11.1.24 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18606608&form=6&db=m Peroxiredoxin II expression and its association with oxidative stress and cell proliferation in human idiopathic pulmonary fibrosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.11.1.24 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31888585&form=6&db=m The overexpression of peroxiredoxin-4 affects the progression of idiopathic pulmonary fibrosis. causal interaction,unassigned 2,0 1.11.1.24 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22158864&form=6&db=m Human umbilical cord blood cells protect oligodendrocytes from brain ischemia through Akt signal transduction. ongoing research,therapeutic application,unassigned 1,1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9119479&form=6&db=m Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9497051&form=6&db=m Molecular cloning, expression and enzymatic activity of a thioredoxin peroxidase from Dirofilaria immitis. ongoing research,therapeutic application,unassigned 2,1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11160011&form=6&db=m Schistosome infection stimulates host CD4(+) T helper cell and B-cell responses against a novel egg antigen, thioredoxin peroxidase. ongoing research,therapeutic application,unassigned 1,2,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14729274&form=6&db=m Functional expression and characterization of Echinococcus granulosus thioredoxin peroxidase suggests a role in protection against oxidative damage. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14976238&form=6&db=m Poplar peroxiredoxin Q. A thioredoxin-linked chloroplast antioxidant functional in pathogen defense. unassigned - 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16968225&form=6&db=m Comparative proteomic analysis of two Entamoeba histolytica strains with different virulence phenotypes identifies peroxiredoxin as an important component of amoebic virulence. causal interaction,unassigned 4,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18005015&form=6&db=m Peroxiredoxin I protects gastric mucosa from oxidative injury induced by H. pylori infection. causal interaction,ongoing research,unassigned 4,1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18022330&form=6&db=m Peroxiredoxins from Trypanosoma cruzi: virulence factors and drug targets for treatment of Chagas disease? ongoing research,unassigned 4,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18708590&form=6&db=m Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages. ongoing research,unassigned 1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19323035&form=6&db=m Differential expression of aldolase, alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from dengue fever and dengue hemorrhagic fever patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19439374&form=6&db=m Biomphalaria glabrata peroxiredoxin: Effect of Schistosoma mansoni infection on differential gene regulation. ongoing research,unassigned 2,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21098483&form=6&db=m Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity. ongoing research,unassigned 1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21185945&form=6&db=m Analysis of thioredoxin peroxidase as a promising antigen for diagnosis of Fasciola gigantica infection A preliminary study. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21532319&form=6&db=m Proteomic profiles of mouse neuro N2a cells infected with variant virulence of rabies viruses. diagnostic usage,therapeutic application,unassigned 1,2,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21964313&form=6&db=m Molecular cloning, expression analysis and characterization of peroxiredoxin during WSSV infection in shrimp Fenneropenaeus indicus. diagnostic usage,ongoing research,unassigned 1,2,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22046130&form=6&db=m Leishmania mitochondrial peroxiredoxin plays a crucial peroxidase-unrelated role during infection: insight into its novel chaperone activity. ongoing research,unassigned 3,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22261090&form=6&db=m Excretory/secretory products from in vitro-cultured Echinococcus granulosus protoscoleces. causal interaction,unassigned 2,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22858408&form=6&db=m JNK/FOXO mediated PeroxiredoxinV expression regulates redox homeostasis during Drosophila melanogaster gut infection. therapeutic application,unassigned 1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22985345&form=6&db=m VACCINE-INDUCED PROTECTION AGAINST MURINE SCHISTOSOMIASIS MANSONI WITH LARVAL EXCRETORY-SECRETORY ANTIGENS AND PAPAIN OR TYPE-2 CYTOKINES. therapeutic application,unassigned 1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23237790&form=6&db=m Expression profiles of peroxiredoxins in liver stage of the rodent malaria parasite Plasmodium berghei. diagnostic usage,unassigned 1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23563952&form=6&db=m Roles of alkyl hydroperoxide reductase subunit C (AhpC) in viable but nonculturable Vibrio parahaemolyticus. causal interaction,unassigned 1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25817695&form=6&db=m Peroxiredoxin 1 protects the pea aphid Acyrthosiphon pisum from oxidative stress induced by Micrococcus luteus infection. ongoing research,unassigned 1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26085147&form=6&db=m Biology of Zika Virus Infection in Human Skin Cells. causal interaction,therapeutic application,unassigned 1,1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26238928&form=6&db=m Identification of a thioredoxin peroxidase gene involved in resistance to nucleopolyhedrovirus infection in Helicoverpa armigera with RNA interference. causal interaction,therapeutic application,unassigned 1,1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26743980&form=6&db=m Up-regulation of cytosolic tryparedoxin in Amp B resistant isolates of Leishmania donovani and its interaction with cytosolic tryparedoxin peroxidase. causal interaction,unassigned 1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27612662&form=6&db=m S-nitrosylation of peroxiredoxin 1 contributes to viability of lung epithelial cells during Bacillus anthracis infection. diagnostic usage,ongoing research,unassigned 4,4,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27644889&form=6&db=m Peroxiredoxin 3 promotes IL-12 production from macrophages and partially protects mice against infection with Toxoplasma gondii. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28359946&form=6&db=m Use of in vivo induced technology to identify antigens expressed by Photobacterium damselae subsp. piscicida during infection of Senegalese sole (Solea senegalensis). unassigned - 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28595515&form=6&db=m Trans-sialidase overcomes many antigens to be used as a vaccine candidate against Trypanosoma cruzi. causal interaction,diagnostic usage,unassigned 2,3,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28743622&form=6&db=m Identification and characterization of atypical 2-cysteine peroxiredoxins from mud crab Scylla paramamosain: The first evidence of two peroxiredoxin 5 genes in non-primate species and their involvement in immune defense against pathogen infection. therapeutic application,unassigned 1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28874771&form=6&db=m Immunization with alkyl hydroperoxide reductase subunit C reduces Fusobacterium nucleatum load in the intestinal tract. unassigned - 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28953980&form=6&db=m Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication. ongoing research,unassigned 1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28964866&form=6&db=m Molecular structure and functional characterization of the peroxiredoxin 5 in Procambarus clarkii following LPS and Poly I:C challenge. causal interaction,unassigned 3,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29032183&form=6&db=m Peroxiredoxin-1 of macrophage is critical for mycobacterial infection and is controlled by early secretory antigenic target protein through the activation of p38 MAPK. causal interaction,unassigned 4,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29408672&form=6&db=m Essential role of the peroxiredoxin 4 in Procambarus clarkii antioxidant defense and immune responses. causal interaction,therapeutic application,unassigned 2,1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29475942&form=6&db=m Induction of autophagy by PI3K/MTOR and PI3K/MTOR/BRD4 inhibitors suppresses HIV-1 replication. ongoing research,therapeutic application,unassigned 4,3,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29716854&form=6&db=m A study of the interaction between H. pylori mice passage strains and gastric epithelial cells. causal interaction,ongoing research,unassigned 1,2,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29972690&form=6&db=m Evaluation of the immune response against Trypanosoma cruzi cytosolic tryparedoxin peroxidase in human natural infection. ongoing research,therapeutic application,unassigned 2,1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30240576&form=6&db=m Potential of recombinant 2-Cys peroxiredoxin protein as a vaccine for Fasciola gigantica infection. therapeutic application,unassigned 4,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31028193&form=6&db=m Protective Role of Peroxiredoxin I in Heat-Killed Staphylococcus Aureus-infected Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31196623&form=6&db=m Brucella infection regulates peroxiredoxin-5 protein expression to facilitate intracellular survival by reducing the production of nitric oxide and reactive oxygen species. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31265897&form=6&db=m Oligomerization dynamics and functionality of Trypanosoma cruzi cytosolic tryparedoxin peroxidase as peroxidase and molecular chaperone. causal interaction,unassigned 4,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31338075&form=6&db=m Molecular Mechanisms of AhpC in Resistance to Oxidative Stress in Burkholderia thailandensis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31536951&form=6&db=m PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31727141&form=6&db=m Thioredoxin peroxidase secreted by Echinococcus granulosus (sensu stricto) promotes the alternative activation of macrophages via PI3K/AKT/mTOR pathway. unassigned - 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31767078&form=6&db=m Cofilin-1, peroxiredoxin-1, and galectin-3: Major proteins released by macrophages infected with Corynebacterium pseudotuberculosis. diagnostic usage,unassigned 1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31861651&form=6&db=m Proteomic Changes during MCMV Infection Revealed by iTRAQ Quantitative Proteomic Analysis in Maize. unassigned - 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32103340&form=6&db=m Blood-based gene expression profile of oxidative stress and antioxidant genes for identifying surrogate markers of liver tissue injury in chronic hepatitis C patients. unassigned - 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32198991&form=6&db=m Comparison of gene expression of pyruvate kinase and tryparedoxin peroxidase in metacyclic promastigote forms of Leishmania (L.) tropica and L. major by real-time PCR ongoing research,unassigned 2,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33415401&form=6&db=m Proteomic analysis reveals differentially abundant proteins probably involved in the virulence of amastigote and promastigote forms of Leishmania infantum. causal interaction,unassigned 1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33656056&form=6&db=m Differential proteomic analysis of children infected with respiratory syncytial virus. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34207550&form=6&db=m Recognition Pattern of the Fasciola hepatica Excretome/Secretome during the Course of an Experimental Infection in Sheep by 2D Immunoproteomics. therapeutic application,unassigned 1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34399627&form=6&db=m Peroxiredoxin Asp f3 Is Essential for Aspergillus fumigatus To Overcome Iron Limitation during Infection. causal interaction,unassigned 1,0 1.11.1.24 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34450129&form=6&db=m Litopenaeus vannamei peroxiredoxin 2-like is involved in WSSV infection by interaction with wsv089 and VP26. therapeutic application,unassigned 1,0 1.11.1.24 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24659586&form=6&db=m Melatonin in testes of infertile men: evidence for anti-proliferative and anti-oxidant effects on local macrophage and mast cell populations. unassigned - 1.11.1.24 Infertility, Male http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24813754&form=6&db=m Proteomics, oxidative stress and male infertility. causal interaction,therapeutic application,unassigned 1,2,0 1.11.1.24 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12529327&form=6&db=m The tetrameric structure of Haemophilus influenza hybrid Prx5 reveals interactions between electron donor and acceptor proteins. ongoing research,unassigned 2,0 1.11.1.24 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25985305&form=6&db=m Redox proteomics of the inflammatory secretome identifies a common set of redoxins and other glutathionylated proteins released in inflammation, influenza virus infection and oxidative stress. ongoing research,unassigned 4,0 1.11.1.24 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29921490&form=6&db=m Peroxiredoxin 1 protein interacts with influenza virus ribonucleoproteins and is required for efficient virus replication. therapeutic application,unassigned 2,0 1.11.1.24 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27303935&form=6&db=m Increased peroxiredoxin 4 levels in patients with prediabetes compared to normal glucose tolerance subjects. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 1.11.1.24 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27523322&form=6&db=m Plekhs1 and Prdx3 are candidate genes responsible for mild hyperglycemia associated with obesity in a new animal model of F344-fa-nidd6 rat. causal interaction,unassigned 1,0 1.11.1.24 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28986255&form=6&db=m Down regulation of Peroxiredoxin-3 in 3T3-L1 adipocytes leads to oxidation of Rictor in the mammalian-target of rapamycin complex 2 (mTORC2). causal interaction,unassigned 4,0 1.11.1.24 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29605633&form=6&db=m Peroxiredoxin 2 mediates insulin sensitivity of skeletal muscles through regulation of protein tyrosine phosphatase oxidation. ongoing research,therapeutic application,unassigned 1,1,0 1.11.1.24 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30980996&form=6&db=m Peroxiredoxin 4 levels in patients with PCOS and/or obesity. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 1.11.1.24 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32141337&form=6&db=m Peroxiredoxin 2 deficiency does not affect insulin resistance and oxidative stress in high-fat diet-fed obese mice. therapeutic application,unassigned 1,0 1.11.1.24 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33256145&form=6&db=m Redox-Oligomeric State of Peroxiredoxin-2 and Glyceraldehyde-3-Phosphate Dehydrogenase in Obstructive Sleep Apnea Red Blood Cells under Positive Airway Pressure Therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 1.11.1.24 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20807727&form=6&db=m Peroxiredoxin III protects pancreatic {beta} cells from apoptosis. ongoing research,therapeutic application,unassigned 1,3,0 1.11.1.24 Intestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17976536&form=6&db=m Adenovirus-mediated transfer of siRNA against peroxiredoxin I enhances the radiosensitivity of human intestinal cancer. ongoing research,therapeutic application,unassigned 3,1,0 1.11.1.24 Intestinal Volvulus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9566516&form=6&db=m Thioredoxin peroxidase from Onchocerca volvulus: a major hydrogen peroxide detoxifying enzyme in filarial parasites. therapeutic application,unassigned 1,0 1.11.1.24 Intestinal Volvulus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9662714&form=6&db=m Molecular cloning of an enzymatically active thioredoxin peroxidase from Onchocerca volvulus. ongoing research,therapeutic application,unassigned 3,2,0 1.11.1.24 Iron Overload http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29906559&form=6&db=m Peroxiredoxin 5 prevents iron overload-induced neuronal death by inhibiting mitochondrial fragmentation and endoplasmic reticulum stress in mouse hippocampal HT-22 cells. unassigned - 1.11.1.24 Irritable Bowel Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31613423&form=6&db=m Peroxiredoxin 1 as an inflammatory marker in diarrhea-predominant and postinfectious irritable bowel syndrome. therapeutic application,unassigned 1,0 1.11.1.24 Irritable Bowel Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33338736&form=6&db=m Association of Peroxiredoxin 1 and brain-derived neurotrophic factor serum levels with depression and anxiety symptoms in patients with irritable bowel syndrome. causal interaction,diagnostic usage,unassigned 3,4,0 1.11.1.24 Ischemic Attack, Transient http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20156553&form=6&db=m Changes in the expression of mitochondrial peroxiredoxin and thioredoxin in neurons and glia and their protective effects in experimental cerebral ischemic damage. ongoing research,unassigned 3,0 1.11.1.24 Ischemic Attack, Transient http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22246227&form=6&db=m Comparison of the Immunoreactivity of Trx2/Prx3 Redox System in the Hippocampal CA1 Region Between the Young and Adult Gerbil Induced by Transient Cerebral Ischemia. causal interaction,ongoing research,unassigned 2,2,0 1.11.1.24 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24385276&form=6&db=m Peroxiredoxin 5 (PRX5) is correlated inversely to systemic markers of inflammation in acute stroke. causal interaction,ongoing research,unassigned 4,2,0 1.11.1.24 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29207618&form=6&db=m Neuroprotective effect of a novel gastrodin derivative against ischemic brain injury: involvement of peroxiredoxin and TLR4 signaling inhibition. causal interaction,therapeutic application,unassigned 4,4,0 1.11.1.24 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29554978&form=6&db=m Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,2,0 1.11.1.24 Keloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20128793&form=6&db=m Comparative proteomic analysis between normal skin and keloid scar. diagnostic usage,unassigned 1,0 1.11.1.24 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12644317&form=6&db=m Identification of antibodies to Leishmania silent information regulatory 2 (SIR2) protein homologue during canine natural infections: pathological implications. unassigned - 1.11.1.24 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21120619&form=6&db=m Cloning, expression and dynamic simulation of TRYP6 from Leishmania major (MRHO/IR/75/ER). unassigned - 1.11.1.24 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22585237&form=6&db=m Molecular diagnosis of Old World leishmaniasis: real-time PCR based on tryparedoxin peroxidase gene for the detection and identification of Leishmania spp. diagnostic usage,unassigned 4,0 1.11.1.24 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25033301&form=6&db=m Leishmania amazonensis amastigotes highly express a tryparedoxin peroxidase isoform that increases parasite resistance to macrophage antimicrobial defenses and Fosters parasite virulence. therapeutic application,unassigned 1,0 1.11.1.24 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25097378&form=6&db=m Tryparedoxin peroxidase of Leishmania braziliensis: homology modeling and inhibitory effects of flavonoids for anti-leishmanial activity. therapeutic application,unassigned 4,0 1.11.1.24 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25769972&form=6&db=m Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review. therapeutic application,unassigned 1,0 1.11.1.24 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29159213&form=6&db=m Dataset generated for Dissection of mechanisms of Trypanothione Reductase and Tryparedoxin Peroxidase through dynamic network analysis and simulations in leishmaniasis. unassigned - 1.11.1.24 Leishmaniasis, Cutaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22585237&form=6&db=m Molecular diagnosis of Old World leishmaniasis: real-time PCR based on tryparedoxin peroxidase gene for the detection and identification of Leishmania spp. diagnostic usage,unassigned 4,0 1.11.1.24 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15885803&form=6&db=m Antibodies against a Leishmania infantum peroxiredoxin as a possible marker for diagnosis of visceral leishmaniasis and for monitoring the efficacy of treatment. diagnostic usage,therapeutic application,unassigned 4,4,0 1.11.1.24 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18312262&form=6&db=m Crucial role of cytosolic tryparedoxin peroxidase in Leishmania donovani survival, drug response and virulence. therapeutic application,unassigned 1,0 1.11.1.24 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25498563&form=6&db=m Immunological consequences of stress-related proteins - cytosolic tryparedoxin peroxidase and chaperonin TCP20 - identified in splenic amastigotes of Leishmania donovani as Th1 stimulatory, in experimental visceral leishmaniasis. unassigned - 1.11.1.24 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9388194&form=6&db=m Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2. ongoing research,unassigned 3,0 1.11.1.24 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19408305&form=6&db=m Downregulation of the c-MYC target gene, peroxiredoxin III, contributes to arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 1.11.1.24 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21283726&form=6&db=m The antioxidant protein peroxiredoxin 4 is epigenetically down regulated in acute promyelocytic leukemia. unassigned - 1.11.1.24 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22900756&form=6&db=m Redox Control of Leukemia: From Molecular Mechanisms to Therapeutic Opportunities. unassigned - 1.11.1.24 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26716647&form=6&db=m Identification of H7 as a novel peroxiredoxin I inhibitor to induce differentiation of leukemia cells. causal interaction,therapeutic application,unassigned 1,3,0 1.11.1.24 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26783013&form=6&db=m Targeting peroxiredoxin I potentiates 1,25-dihydroxyvitamin D3-induced cell differentiation in leukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 1.11.1.24 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28043837&form=6&db=m Targeting antioxidant enzyme expression as a therapeutic strategy for ischemic stroke. causal interaction,therapeutic application,unassigned 3,1,0 1.11.1.24 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31418361&form=6&db=m [Adenanthin Induces Differentiation of Acute Promyelocytic Leukemia Cells by Targeting Peroxiredoxin III]. unassigned - 1.11.1.24 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32975211&form=6&db=m Peroxiredoxin 3 Has Important Roles on Arsenic Trioxide Induced Apoptosis in Human Acute Promyelocytic Leukemia Cell Line via Hyperoxidation of Mitochondrial Specific Reactive Oxygen Species. causal interaction,ongoing research,unassigned 1,3,0 1.11.1.24 Leukemia, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23358497&form=6&db=m Cytotoxicity and expression of genes involved in the cellular stress response and apoptosis in mammalian fibroblast exposed to cotton cellulose nanofibers. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 1.11.1.24 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17574212&form=6&db=m The role of peroxiredoxin III on late stage of proerythrocyte differentiation. ongoing research,unassigned 1,0 1.11.1.24 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23113308&form=6&db=m Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.11.1.24 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16932348&form=6&db=m Downregulation of topoisomerase IIbeta in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 1.11.1.24 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17026836&form=6&db=m Peroxiredoxin genes are not induced in myeloid leukemia cells exposed to ionizing radiation. unassigned - 1.11.1.24 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30245403&form=6&db=m Genetic and Epigenetic Perturbations by DNMT3A-R882 Mutants Impaired Apoptosis through Augmentation of PRDX2 in Myeloid Leukemia Cells. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,2,0 1.11.1.24 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15188461&form=6&db=m PRDX4, a member of the peroxiredoxin family, is fused to AML1 (RUNX1) in an acute myeloid leukemia patient with a t(X;21)(p22;q22). unassigned - 1.11.1.24 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24828865&form=6&db=m MicroRNA-26a-5p and microRNA-23b-3p up-regulate peroxiredoxin III in acute myeloid leukemia. diagnostic usage,unassigned 1,0 1.11.1.24 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30581529&form=6&db=m Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells. causal interaction,therapeutic application,unassigned 4,2,0 1.11.1.24 Leukemia, Promyelocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19408305&form=6&db=m Downregulation of the c-MYC target gene, peroxiredoxin III, contributes to arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 1.11.1.24 Leukemia, Promyelocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21283726&form=6&db=m The antioxidant protein peroxiredoxin 4 is epigenetically down regulated in acute promyelocytic leukemia. unassigned - 1.11.1.24 Leukemia, Promyelocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31418361&form=6&db=m [Adenanthin Induces Differentiation of Acute Promyelocytic Leukemia Cells by Targeting Peroxiredoxin III]. unassigned - 1.11.1.24 Leukemia, Promyelocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32975211&form=6&db=m Peroxiredoxin 3 Has Important Roles on Arsenic Trioxide Induced Apoptosis in Human Acute Promyelocytic Leukemia Cell Line via Hyperoxidation of Mitochondrial Specific Reactive Oxygen Species. causal interaction,ongoing research,unassigned 1,3,0 1.11.1.24 Leukoplakia, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26622762&form=6&db=m Peroxiredoxin 1 suppresses apoptosis via regulation of the apoptosis signal-regulating kinase 1 signaling pathway in human oral leukoplakia. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 1.11.1.24 Leukoplakia, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31525533&form=6&db=m Proteome profiling to identify peroxiredoxin 1 interacting protein partners in nicotine-associated oral leukoplakia. ongoing research,therapeutic application,unassigned 1,2,0 1.11.1.24 Leukoplakia, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34076143&form=6&db=m Nicotine promotes the development of oral leukoplakia via regulating peroxiredoxin 1 and its binding proteins. causal interaction,unassigned 3,0 1.11.1.24 Lipoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22976689&form=6&db=m Adult rhabdomyoma with oncocytic changes affecting the floor of the mouth: optical, immunohistochemical, and ultrastructural study. causal interaction,unassigned 1,0 1.11.1.24 Liver Abscess http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24822193&form=6&db=m Peroxynitrite and peroxiredoxin in the pathogenesis of experimental amebic liver abscess. ongoing research,unassigned 1,0 1.11.1.24 Liver Abscess, Amebic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22266120&form=6&db=m Obtaining of three recombinant antigens of Entamoeba histolytica and evaluation of their immunogenic ability without adjuvant in a hamster model of immunoprotection. ongoing research,unassigned 3,0 1.11.1.24 Liver Abscess, Amebic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24822193&form=6&db=m Peroxynitrite and peroxiredoxin in the pathogenesis of experimental amebic liver abscess. ongoing research,unassigned 1,0 1.11.1.24 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20939925&form=6&db=m Peroxiredoxin 2: a potential biomarker for early diagnosis of hepatitis B virus related liver fibrosis identified by proteomic analysis of the plasma. causal interaction,diagnostic usage,unassigned 4,4,0 1.11.1.24 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27035833&form=6&db=m Overexpression of Peroxiredoxin 4 Affects Intestinal Function in a Dietary Mouse Model of Nonalcoholic Fatty Liver Disease. ongoing research,unassigned 3,0 1.11.1.24 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29341349&form=6&db=m Peroxiredoxin 4 (PRDX4): Its critical in vivo roles in animal models of metabolic syndrome ranging from atherosclerosis to nonalcoholic fatty liver disease. ongoing research,unassigned 2,0 1.11.1.24 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31505325&form=6&db=m Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling. causal interaction,therapeutic application,unassigned 1,1,0 1.11.1.24 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33072014&form=6&db=m Identification and Analysis of the Tegument Protein and Excretory-Secretory Products of the Carcinogenic Liver Fluke Clonorchis sinensis. diagnostic usage,unassigned 1,0 1.11.1.24 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34054813&form=6&db=m Peroxiredoxin 3 Inhibits Acetaminophen-Induced Liver Pyroptosis Through the Regulation of Mitochondrial ROS. unassigned - 1.11.1.24 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30050648&form=6&db=m Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure. causal interaction,therapeutic application,unassigned 3,1,0 1.11.1.24 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18318006&form=6&db=m Proteome analysis of aflatoxin B1-induced hepatocarcinogenesis in tree shrew (Tupaia belangeri chinensis) and functional identification of candidate protein peroxiredoxin II. ongoing research,therapeutic application,unassigned 3,3,0 1.11.1.24 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18578994&form=6&db=m [The biological function of peroxiredoxin II on Hep3B cells and its underlying mechanism] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2 1.11.1.24 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19406930&form=6&db=m Peroxiredoxin I contributes to TRAIL resistance through suppression of redox-sensitive caspase activation in human hepatoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 1.11.1.24 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24105047&form=6&db=m Peroxiredoxin 3 is resistant to oxidation-induced apoptosis of Hep-3b cells. unassigned - 1.11.1.24 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25886747&form=6&db=m Gamma-tocotrienol treatment increased peroxiredoxin-4 expression in HepG2 liver cancer cell line. causal interaction,therapeutic application,unassigned 1,1,0 1.11.1.24 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26478675&form=6&db=m Aberrant expression of peroxiredoxin 1 and its clinical implications in liver cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 1.11.1.24 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26866938&form=6&db=m Peroxiredoxin II is essential for maintaining stemness by redox regulation in liver cancer cells. diagnostic usage,ongoing research,unassigned 3,1,0 1.11.1.24 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11509333&form=6&db=m Induction of peroxiredoxin gene expression by oxygen in lungs of newborn primates. unassigned - 1.11.1.24 Lung Diseases, Interstitial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18606608&form=6&db=m Peroxiredoxin II expression and its association with oxidative stress and cell proliferation in human idiopathic pulmonary fibrosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11716502&form=6&db=m Augmented expression of peroxiredoxin I in lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14703116&form=6&db=m Preferential elevation of Prx I and Trx expression in lung cancer cells following hypoxia and in human lung cancer tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16414373&form=6&db=m Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16635084&form=6&db=m Expression of peroxiredoxin and thioredoxin in human lung cancer and paired normal lung. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16849559&form=6&db=m Prx1 suppresses radiation-induced c-Jun NH2-terminal kinase signaling in lung cancer cells through interaction with the glutathione S-transferase Pi/c-Jun NH2-terminal kinase complex. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17084559&form=6&db=m p53 status is a major determinant of effects of decreasing peroxiredoxin I expression on tumor growth and response of lung cancer cells to treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17606720&form=6&db=m Elevated peroxiredoxin 1, but not NF-E2-related factor 2, is an independent prognostic factor for disease recurrence and reduced survival in stage I non-small cell lung cancer. causal interaction,diagnostic usage,unassigned 3,4,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18413821&form=6&db=m Up-regulation of peroxiredoxin 1 in lung cancer and its implication as a prognostic and therapeutic target. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19412661&form=6&db=m Glycoproteomic Analysis of Human Lung Adenocarcinomas Using Glycoarrays and Tandem Mass Spectrometry: Differential Expression and Glycosylation Patterns of Vimentin and Fetuin A Isoforms. unassigned - 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19797004&form=6&db=m Preferential overexpression of glutaredoxin3 in human colon and lung carcinoma. causal interaction,diagnostic usage,unassigned 2,2,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22016591&form=6&db=m Nuclear factor E2-related factor 2 dependent overexpression of sulfiredoxin and peroxiredoxin III in human lung cancer. causal interaction,unassigned 2,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22022930&form=6&db=m Downregulation of Peroxiredoxin I by a Novel Fully Human Phage Display Recombinant Antibody Induces Apoptosis and Enhances Radiation Sensitization in A549 Lung Carcinoma Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22537621&form=6&db=m Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23042266&form=6&db=m Secretomic analysis of large cell lung cancer cell lines using two-dimensional gel electrophoresis coupled to mass spectrometry. causal interaction,diagnostic usage,unassigned 2,2,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25232487&form=6&db=m Expression of peroxiredoxin 1 and 4 promotes human lung cancer malignancy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26021759&form=6&db=m An important role for peroxiredoxin II in survival of A549 lung cancer cells resistant to gefitinib. causal interaction,ongoing research,unassigned 4,3,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26261544&form=6&db=m Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30568461&form=6&db=m Prognostic roles of mRNA expression of peroxiredoxins in lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30988280&form=6&db=m S-nitrosylation of the Peroxiredoxin-2 promotes S-nitrosoglutathione-mediated lung cancer cells apoptosis via AMPK-SIRT1 pathway. therapeutic application,unassigned 4,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31101821&form=6&db=m Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis. causal interaction,unassigned 1,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31311441&form=6&db=m PRDX4 and Its Roles in Various Cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31500275&form=6&db=m Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31567534&form=6&db=m Reactive oxygen species-regulating proteins peroxiredoxin 2 and thioredoxin, and glyceraldehyde-3-phosphate dehydrogenase are differentially abundant in induced sputum from smokers with lung cancer or asbestos exposure. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32232956&form=6&db=m Proteomic and genomic biomarkers for Non-Small Cell Lung Cancer: Peroxiredoxin, Haptoglobin, and Alpha-1 antitrypsin. diagnostic usage,therapeutic application,unassigned 1,1,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32337219&form=6&db=m Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells. causal interaction,ongoing research,unassigned 1,2,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32908916&form=6&db=m PRDX2 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer In Vitro and In Vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33416106&form=6&db=m ROS?mediated hypomethylation of PRDX5 promotes STAT3 binding and activates the Nrf2 signaling pathway in NSCLC. causal interaction,diagnostic usage,unassigned 2,2,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33456675&form=6&db=m Overexpression of PRDX4 Modulates Tumor Microenvironment and Promotes Urethane-Induced Lung Tumorigenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 1.11.1.24 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33907575&form=6&db=m Regulatory function of peroxiredoxin I on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung cancer development. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 1.11.1.24 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15665454&form=6&db=m Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 1.11.1.24 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10840156&form=6&db=m Peroxiredoxin I expression in oral cancer: a potential new tumor marker. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 1.11.1.24 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22430214&form=6&db=m Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 1.11.1.24 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28125800&form=6&db=m Peroxiredoxin 2 is associated with colorectal cancer progression and poor survival of patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30214590&form=6&db=m Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.11.1.24 Lymphocytic Choriomeningitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31708904&form=6&db=m Quantitative Proteomics Reveal Peroxiredoxin Perturbation Upon Persistent Lymphocytic Choriomeningitis Virus Infection in Human Cells. causal interaction,ongoing research,unassigned 2,2,0 1.11.1.24 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26636537&form=6&db=m Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma. causal interaction,ongoing research,unassigned 4,1,0 1.11.1.24 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28742189&form=6&db=m Novel endogenous negative modulators of platelet function as potential anti-thrombotic targets. ongoing research,unassigned 2,0 1.11.1.24 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30020823&form=6&db=m Epigenetic silencing of the tumor suppressor genes SPI1, PRDX2, KLF4, DLEC1, and DAPK1 in childhood and adolescent lymphomas. diagnostic usage,ongoing research,unassigned 3,2,0 1.11.1.24 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30468473&form=6&db=m Cisplatin induces apoptosis of A549 cells by downregulating peroxidase V. ongoing research,unassigned 3,0 1.11.1.24 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25359615&form=6&db=m Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells. therapeutic application,unassigned 1,0 1.11.1.24 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32764528&form=6&db=m Protective Effect of Fenofibrate on Oxidative Stress-Induced Apoptosis in Retinal-Choroidal Vascular Endothelial Cells: Implication for Diabetic Retinopathy Treatment. causal interaction,therapeutic application,unassigned 1,1,0 1.11.1.24 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33813388&form=6&db=m Peroxiredoxin V Silencing Elevates Susceptibility to Doxorubicin-induced Cell Apoptosis via ROS-dependent Mitochondrial Dysfunction in AGS Gastric Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Lymphoma, Follicular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26983700&form=6&db=m Total peroxiredoxin expression is associated with survival in patients with follicular lymphoma. causal interaction,diagnostic usage,unassigned 3,4,0 1.11.1.24 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10960175&form=6&db=m Molecular cloning and characterization of a peroxiredoxin from the human malaria parasite Plasmodium falciparum. ongoing research,therapeutic application,unassigned 4,1,0 1.11.1.24 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11463468&form=6&db=m Molecular characterization of a 2-Cys peroxiredoxin from the human malaria parasite Plasmodium falciparum. ongoing research,therapeutic application,unassigned 4,2,0 1.11.1.24 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11898428&form=6&db=m Thioredoxin, thioredoxin reductase, and thioredoxin peroxidase of malaria parasite Plasmodium falciparum. diagnostic usage,unassigned 3,0 1.11.1.24 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14572508&form=6&db=m Expression profiles of peroxiredoxin proteins of the rodent malaria parasite Plasmodium yoelii. ongoing research,unassigned 2,0 1.11.1.24 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15794764&form=6&db=m Roles of 1-Cys peroxiredoxin in haem detoxification in the human malaria parasite Plasmodium falciparum. ongoing research,unassigned 2,0 1.11.1.24 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16540402&form=6&db=m A mosquito 2-Cys peroxiredoxin protects against nitrosative and oxidative stresses associated with malaria parasite infection. causal interaction,therapeutic application,unassigned 2,1,0 1.11.1.24 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16597467&form=6&db=m 2-Cys Peroxiredoxin TPx-1 is involved in gametocyte development in Plasmodium berghei. ongoing research,unassigned 4,0 1.11.1.24 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16910770&form=6&db=m Thioredoxin networks in the malarial parasite Plasmodium falciparum. ongoing research,unassigned 4,0 1.11.1.24 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17890140&form=6&db=m Peroxiredoxins in malaria parasites: parasitologic aspects. unassigned - 1.11.1.24 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21282103&form=6&db=m A Genome-wide Chromatin-associated Nuclear Peroxiredoxin from the Malaria Parasite Plasmodium falciparum. therapeutic application,unassigned 1,0 1.11.1.24 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24637102&form=6&db=m Molecular cloning, characterization and expression profile of a glutathione peroxidase-like thioredoxin peroxidase (TPxGl) of the rodent malaria parasite Plasmodium berghei. ongoing research,unassigned 2,0 1.11.1.24 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25913091&form=6&db=m Development of monoclonal antibodies against Plasmodium falciparum thioredoxin peroxidase 1 and its possible application for malaria diagnosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,4 1.11.1.24 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28357258&form=6&db=m Prokaryotic ancestry and gene fusion of a dual localized peroxiredoxin in malaria parasites. therapeutic application,unassigned 1,0 1.11.1.24 Measles http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21159870&form=6&db=m Peroxiredoxin 1 is required for efficient transcription and replication of measles virus. diagnostic usage,unassigned 3,0 1.11.1.24 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23227829&form=6&db=m MiR-383 is Downregulated in Medulloblastoma and Targets Peroxiredoxin 3 (PRDX3). causal interaction,unassigned 2,0 1.11.1.24 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25909245&form=6&db=m Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study. unassigned - 1.11.1.24 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31533285&form=6&db=m Validation of Cadherin HAV6 Peptide in the Transient Modulation of the Blood-Brain Barrier for the Treatment of Brain Tumors. causal interaction,therapeutic application,unassigned 2,2,0 1.11.1.24 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15695408&form=6&db=m Immunogenicity without immunoselection: a mutant but functional antioxidant enzyme retained in a human metastatic melanoma and targeted by CD8(+) T cells with a memory phenotype. ongoing research,unassigned 3,0 1.11.1.24 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16034300&form=6&db=m Analysis of candidate genes through a proteomics-based approach in primary cell lines from malignant melanomas and their metastases. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 1.11.1.24 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778180&form=6&db=m Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas. diagnostic usage,ongoing research,unassigned 3,4,0 1.11.1.24 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19181932&form=6&db=m Peptides with dual binding specificity for HLA-A2 and HLA-E are encoded by alternatively spliced isoforms of the antioxidant enzyme peroxiredoxin 5. ongoing research,unassigned 3,0 1.11.1.24 Melioidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25862821&form=6&db=m T Cell Immunity to the Alkyl Hydroperoxide Reductase of Burkholderia pseudomallei: A Correlate of Disease Outcome in Acute Melioidosis. diagnostic usage,unassigned 3,0 1.11.1.24 Meningitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22003971&form=6&db=m A novel anti-peroxiredoxin autoantibody in patients with Kawasaki disease. causal interaction,diagnostic usage,unassigned 1,3,0 1.11.1.24 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22761781&form=6&db=m Peroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma cells. therapeutic application,unassigned 1,0 1.11.1.24 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23018647&form=6&db=m Mitochondrial-targeted nitroxides disrupt mitochondrial architecture and inhibit expression of peroxiredoxin 3 and FOXM1 in malignant mesothelioma cells. unassigned - 1.11.1.24 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25462069&form=6&db=m Peroxiredoxin 3 levels regulate a mitochondrial redox setpoint in malignant mesothelioma cells. unassigned - 1.11.1.24 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26011724&form=6&db=m Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma. ongoing research,therapeutic application,unassigned 2,4,0 1.11.1.24 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25891757&form=6&db=m Improvement of Plasma Biomarkers after Switching Stroke Patients from Other Angiotensin II Type I Receptor Blockers to Olmesartan. causal interaction,diagnostic usage,unassigned 1,4,0 1.11.1.24 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27303935&form=6&db=m Increased peroxiredoxin 4 levels in patients with prediabetes compared to normal glucose tolerance subjects. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 1.11.1.24 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29341349&form=6&db=m Peroxiredoxin 4 (PRDX4): Its critical in vivo roles in animal models of metabolic syndrome ranging from atherosclerosis to nonalcoholic fatty liver disease. ongoing research,unassigned 2,0 1.11.1.24 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30980996&form=6&db=m Peroxiredoxin 4 levels in patients with PCOS and/or obesity. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 1.11.1.24 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19134454&form=6&db=m [Herbs for calming liver and suppressing liver-yang in treatment of migraine with hyperactive liver-yang syndrome and its effects on lymphocyte protein expression: a randomized controlled trial] diagnostic usage,unassigned 1,0 1.11.1.24 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10840156&form=6&db=m Peroxiredoxin I expression in oral cancer: a potential new tumor marker. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 1.11.1.24 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22335413&form=6&db=m High-throughput screening of saliva for early detection of oral cancer: a pilot study. diagnostic usage,ongoing research,unassigned 3,4,0 1.11.1.24 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25162226&form=6&db=m Induction of peroxiredoxin 1 by hypoxia regulates heme oxygenase-1 via NF-?B in oral cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 1.11.1.24 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31118684&form=6&db=m Nicotine promotes cervical metastasis of oral cancer by regulating peroxiredoxin 1 and epithelial-mesenchymal transition in mice. ongoing research,unassigned 4,0 1.11.1.24 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18565146&form=6&db=m Peroxiredoxin I is differentially expressed in multiple myelomas and in plasmablastic lymphomas. causal interaction,unassigned 2,0 1.11.1.24 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22329198&form=6&db=m The role of peroxiredoxin V in (-)-epigallocatechin 3-gallate-induced multiple myeloma cell death. unassigned - 1.11.1.24 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17623739&form=6&db=m Peroxiredoxin V in multiple sclerosis lesions: predominant expression by astrocytes. unassigned - 1.11.1.24 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28375164&form=6&db=m Expression of the Antioxidative Enzyme Peroxiredoxin 2 in Multiple Sclerosis Lesions in Relation to Inflammation. causal interaction,ongoing research,unassigned 1,1,0 1.11.1.24 Myasthenia Gravis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26439955&form=6&db=m Increased serum peroxiredoxin 5 levels in myasthenia gravis. diagnostic usage,unassigned 4,0 1.11.1.24 Mycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15840643&form=6&db=m A peroxiredoxin Q homolog from gentians is involved in both resistance against fungal disease and oxidative stress. causal interaction,therapeutic application,unassigned 2,1,0 1.11.1.24 Mycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28874754&form=6&db=m ROS-induced Oxidative Injury involved in Pathogenesis of Fungal Keratitis via p38 MAPK Activation. causal interaction,therapeutic application,unassigned 4,4,0 1.11.1.24 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16585391&form=6&db=m Overexpression of mitochondrial peroxiredoxin-3 prevents left ventricular remodeling and failure after myocardial infarction in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 1.11.1.24 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28765537&form=6&db=m PRDX2 in Myocyte Hypertrophy and Survival is Mediated by TLR4 in Acute Infarcted Myocardium. causal interaction,unassigned 3,0 1.11.1.24 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33268762&form=6&db=m Peroxiredoxin2 (Prdx2) Reduces Oxidative Stress and Apoptosis of Myocardial Cells Induced by Acute Myocardial Infarction by Inhibiting the TLR4/Nuclear Factor kappa B (NF-?B) Signaling Pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 1.11.1.24 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28184180&form=6&db=m Serum proteomic-based analysis identifying autoantibodies against PRDX2 and PRDX3 as potential diagnostic biomarkers in nasopharyngeal carcinoma. diagnostic usage,unassigned 4,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10840156&form=6&db=m Peroxiredoxin I expression in oral cancer: a potential new tumor marker. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16192647&form=6&db=m Bcl-x(L)-mediated changes in metabolic pathways of breast cancer cells: from survival in the blood stream to organ-specific metastasis. causal interaction,therapeutic application,unassigned 2,1,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16325936&form=6&db=m Comparative protein profiling identifies elongation factor-1beta and tryparedoxin peroxidase as factors associated with metastasis in Leishmania guyanensis. diagnostic usage,unassigned 1,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16414373&form=6&db=m Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16725008&form=6&db=m Oxidative/nitrosative stress and peroxiredoxin 2 are associated with grade and prognosis of human renal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17980029&form=6&db=m Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21136991&form=6&db=m Comprehensive profiling of metastasis-related proteins in paired hepatocellular carcinoma cells with different metastasis potentials. causal interaction,unassigned 3,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21224047&form=6&db=m Identification of potential biomarkers for giant cell tumor of bone using comparative proteomics analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21434354&form=6&db=m [Effects of yiqi chutan recipe on tumor growth, survival time and expressions of PRDX-1 and PRDX-6 in Lewis lung carcinoma model mice with pi-deficiency syndrome]. ongoing research,unassigned 4,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21475635&form=6&db=m Protein Signatures in Human MDA-MB-231 Breast Cancer Cells Indicating a More Invasive Phenotype Following Knockdown of Human Endometase/Matrilysin-2 by siRNA. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22430214&form=6&db=m Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23393224&form=6&db=m Prognostic role of serum AZGP1, PEDF and PRDX2 in colorectal cancer patients. causal interaction,diagnostic usage,unassigned 3,3,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24234423&form=6&db=m Peroxiredoxin 2 is upregulated in colorectal cancer and contributes to colorectal cancer cells' survival by protecting cells from oxidative stress. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24920174&form=6&db=m Overexpression of peroxiredoxin 2 inhibits TGF-?1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28125800&form=6&db=m Peroxiredoxin 2 is associated with colorectal cancer progression and poor survival of patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29258530&form=6&db=m Disruption of the c-Myc/miR-200b-3p/PRDX2 regulatory loop enhances tumor metastasis and chemotherapeutic resistance in colorectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29492195&form=6&db=m Peroxiredoxin-1 promotes cell proliferation and metastasis through enhancing Akt/mTOR in human osteosarcoma cells. causal interaction,ongoing research,unassigned 2,4,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29673884&form=6&db=m Peroxiredoxin 1 promoted tumor metastasis and angiogenesis in colorectal cancer. causal interaction,diagnostic usage,unassigned 4,3,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29908016&form=6&db=m Peroxiredoxin 1 (PRDX1) Suppresses Progressions and Metastasis of Osteosarcoma and Fibrosarcoma of Bone. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30214590&form=6&db=m Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30568461&form=6&db=m Prognostic roles of mRNA expression of peroxiredoxins in lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31018997&form=6&db=m SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,1,3,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31101821&form=6&db=m Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis. causal interaction,unassigned 1,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31118684&form=6&db=m Nicotine promotes cervical metastasis of oral cancer by regulating peroxiredoxin 1 and epithelial-mesenchymal transition in mice. ongoing research,unassigned 4,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31256347&form=6&db=m Peroxiredoxin 4 suppresses anoikis and augments growth and metastasis of hepatocellular carcinoma cells through the ?-catenin/ID2 pathway. causal interaction,therapeutic application,unassigned 3,1,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31311441&form=6&db=m PRDX4 and Its Roles in Various Cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31956363&form=6&db=m Up-regulation of peroxiredoxin-1 promotes cell proliferation and metastasis and inhibits apoptosis in cervical cancer. diagnostic usage,ongoing research,unassigned 3,4,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32908916&form=6&db=m PRDX2 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer In Vitro and In Vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33416106&form=6&db=m ROS?mediated hypomethylation of PRDX5 promotes STAT3 binding and activates the Nrf2 signaling pathway in NSCLC. causal interaction,diagnostic usage,unassigned 2,2,0 1.11.1.24 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33819194&form=6&db=m The critical role of peroxiredoxin-2 in colon cancer stem cells. causal interaction,unassigned 2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9497357&form=6&db=m Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha. ongoing research,therapeutic application,unassigned 2,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10530780&form=6&db=m Peroxiredoxin I expression in human thyroid tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10840156&form=6&db=m Peroxiredoxin I expression in oral cancer: a potential new tumor marker. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11156252&form=6&db=m Antisense of human peroxiredoxin II enhances radiation-induced cell death. ongoing research,therapeutic application,unassigned 4,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11396151&form=6&db=m Increased expression of peroxiredoxin II confers resistance to cisplatin. causal interaction,therapeutic application,unassigned 3,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11716502&form=6&db=m Augmented expression of peroxiredoxin I in lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11904290&form=6&db=m Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site. therapeutic application,unassigned 2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12112852&form=6&db=m Detection of cathepsin B up-regulation in neoplastic thyroid tissues by proteomic analysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12515392&form=6&db=m Synergistic effect of peroxiredoxin II antisense on cisplatin-induced cell death. ongoing research,therapeutic application,unassigned 3,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12530083&form=6&db=m Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12861054&form=6&db=m Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis. unassigned - 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12891360&form=6&db=m Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. unassigned - 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12960131&form=6&db=m Peroxiredoxins in breast carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12963914&form=6&db=m Expression of peroxiredoxin II in vascular tumors of the skin: a novel vascular marker of endothelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14597634&form=6&db=m Cytosolic peroxiredoxin attenuates the activation of Jnk and p38 but potentiates that of Erk in Hela cells stimulated with tumor necrosis factor-alpha. causal interaction,therapeutic application,unassigned 3,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14703116&form=6&db=m Preferential elevation of Prx I and Trx expression in lung cancer cells following hypoxia and in human lung cancer tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14765133&form=6&db=m Hydrogen peroxide produced by Aplysia ink toxin kills tumor cells independent of apoptosis via peroxiredoxin I sensitive pathways. ongoing research,unassigned 1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15239128&form=6&db=m Peroxiredoxins, a novel protein family in lung cancer. causal interaction,diagnostic usage,unassigned 4,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15604267&form=6&db=m Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry. diagnostic usage,unassigned 3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15655364&form=6&db=m c-Abl in oxidative stress, aging and cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15955662&form=6&db=m Peroxiredoxin I expression in tongue squamous cell carcinomas as involved in tumor recurrence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15986332&form=6&db=m Comparative proteomic analysis of esophageal squamous cell carcinoma. diagnostic usage,ongoing research,unassigned 3,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16288023&form=6&db=m The role of peroxiredoxin II in radiation-resistant MCF-7 breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16353146&form=6&db=m Expression of multiple epigenetically regulated cancer/germline genes in nonsmall cell lung cancer. ongoing research,unassigned 2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16414373&form=6&db=m Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16516038&form=6&db=m Enhanced Expression of Peroxiredoxin I and VI Correlates with Development, Recurrence and Progression of Human Bladder Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16635084&form=6&db=m Expression of peroxiredoxin and thioredoxin in human lung cancer and paired normal lung. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16725008&form=6&db=m Oxidative/nitrosative stress and peroxiredoxin 2 are associated with grade and prognosis of human renal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16773180&form=6&db=m Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemoresistant tumors. unassigned - 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17084559&form=6&db=m p53 status is a major determinant of effects of decreasing peroxiredoxin I expression on tumor growth and response of lung cancer cells to treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17085654&form=6&db=m Proteomics-based approach identifying autoantibody against peroxiredoxin VI as a novel serum marker in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,2 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17234762&form=6&db=m Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology. causal interaction,unassigned 4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17537404&form=6&db=m Drug resistance to 5-FU linked to reactive oxygen species modulator 1. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17855346&form=6&db=m Oxidation of 2-Cys-peroxiredoxins by arachidonic acid peroxide metabolites of lipoxygenases and cyclooxygenase-2. ongoing research,unassigned 1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17907597&form=6&db=m Peroxiredoxins and antioxidant enzymes in pilocytic astrocytomas. causal interaction,unassigned 3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17988525&form=6&db=m [Proteomic analysis on portal vein tumor thrombus-associated proteins for hepatocellular carcinoma] causal interaction,diagnostic usage,unassigned 1,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18272409&form=6&db=m Involvement of peroxiredoxin IV in the 16alpha-hydroxyestrone-induced proliferation of human MCF-7 breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18318006&form=6&db=m Proteome analysis of aflatoxin B1-induced hepatocarcinogenesis in tree shrew (Tupaia belangeri chinensis) and functional identification of candidate protein peroxiredoxin II. ongoing research,therapeutic application,unassigned 3,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18324346&form=6&db=m Candidate diagnostic markers and tumor suppressor genes for adrenocortical carcinoma by expression profile of genes on chromosome 11q13. diagnostic usage,unassigned 1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18578994&form=6&db=m [The biological function of peroxiredoxin II on Hep3B cells and its underlying mechanism] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18665625&form=6&db=m Fine-needle aspiration of thyroid nodules: proteomic analysis to identify cancer biomarkers. unassigned - 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19064914&form=6&db=m A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance. therapeutic application,unassigned 1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19137544&form=6&db=m Highly sensitive saturation labeling reveals changes in abundance of cell cycle-associated proteins and redox enzyme variants during oocyte maturation in vitro. diagnostic usage,unassigned 3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19424615&form=6&db=m Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19556853&form=6&db=m Production and radioimmunoimaging of novel fully human phage display recombinant antibodies and growth inhibition of lung adenocarcinoma cell line overexpressing Prx I. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19566940&form=6&db=m Overexpression of peroxiredoxin I and thioredoxin1 in human breast carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19646526&form=6&db=m Protective role of cytosolic 2-cys peroxiredoxin in the TNF-alpha-induced apoptotic death of human cancer cells. causal interaction,ongoing research,unassigned 1,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19799814&form=6&db=m Inhibitory effect of novel internalized fully human phage antibody fragments on proliferation of lung adenocarcinoma cell line overexpressing peroxiredoxin I. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20003713&form=6&db=m Overexpression of Prdx6 and resistance to peroxide-induced death in Hepa1-6 cells: Prdx suppression increases apoptosis. causal interaction,ongoing research,unassigned 4,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20018613&form=6&db=m Peroxiredoxin 1 stimulates secretion of proinflammatory cytokines by binding to TLR4. unassigned - 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20043069&form=6&db=m Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20113375&form=6&db=m Glucose transporter protein 1 expression in mucoepidermoid carcinoma of salivary gland: correlation with grade of malignancy. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20128793&form=6&db=m Comparative proteomic analysis between normal skin and keloid scar. diagnostic usage,unassigned 1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20206498&form=6&db=m Oxidative stress-induced antioxidant enzyme expression is an early phenomenon in ovarian carcinogenesis. causal interaction,diagnostic usage,unassigned 3,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20307276&form=6&db=m Specific expression profile and prognostic significance of peroxiredoxins in grade II-IV astrocytic brain tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20732753&form=6&db=m Role of peroxiredoxin I in rectal cancer and related to p53 status. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20975997&form=6&db=m Differential protein expression in honeybee (Apis mellifera L.) larvae: underlying caste differentiation. unassigned - 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21148313&form=6&db=m Peroxiredoxin II Restrains DNA Damage-induced Death in Cancer Cells by Positively Regulating JNK-dependent DNA Repair. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21187494&form=6&db=m Investigation of peroxiredoxin IV as a calpain-regulated pathway in cancer. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21224047&form=6&db=m Identification of potential biomarkers for giant cell tumor of bone using comparative proteomics analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21239607&form=6&db=m Aggravation of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice Lacking Peroxiredoxin I. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21343392&form=6&db=m Peroxiredoxin 1 controls prostate cancer growth through Toll-like receptor 4-dependent regulation of tumor vasculature. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21359112&form=6&db=m IDENTIFICATION OF CONOIDIN A AS A COVALENT INHIBITOR OF PEROXIREDOXIN II. unassigned - 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21434354&form=6&db=m [Effects of yiqi chutan recipe on tumor growth, survival time and expressions of PRDX-1 and PRDX-6 in Lewis lung carcinoma model mice with pi-deficiency syndrome]. ongoing research,unassigned 4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21478820&form=6&db=m 2D-DIGE Proteomic Analysis of Changes in Estrogen/Progesterone-Induced Rat Breast Hyperplasia upon Treatment with the Mongolian Remedy RuXian-I. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21487522&form=6&db=m 8-hydroxydeguanosine and nitrotyrosine are prognostic factors in urinary bladder carcinoma. causal interaction,diagnostic usage,unassigned 3,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21805023&form=6&db=m Proteomic analysis of psoriatic skin tissue for identification of differentially expressed proteins: Up-regulation of GSTP1, SFN and PRDX2 in psoriatic skin. causal interaction,unassigned 4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22022930&form=6&db=m Downregulation of Peroxiredoxin I by a Novel Fully Human Phage Display Recombinant Antibody Induces Apoptosis and Enhances Radiation Sensitization in A549 Lung Carcinoma Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22064513&form=6&db=m Identification of isocitrate dehydrogenase 1 as a potential diagnostic and prognostic biomarker for non-small cell lung cancer by proteomic analysis. diagnostic usage,therapeutic application,unassigned 4,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22072940&form=6&db=m Mitochondrial Peroxiredoxin III is a Potential Target for Cancer Therapy. causal interaction,therapeutic application,unassigned 4,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22099303&form=6&db=m Peroxiredoxin II is an essential antioxidant enzyme that prevents the oxidative inactivation of VEGF receptor-2 in vascular endothelial cells. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22110952&form=6&db=m Proteomic-based biosignatures in breast cancer classification and prediction of therapeutic response. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22207736&form=6&db=m Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22245228&form=6&db=m Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival. unassigned - 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22424448&form=6&db=m Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro. ongoing research,unassigned 3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22430214&form=6&db=m Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22446018&form=6&db=m Prognostic significance of peroxiredoxin 1 and ezrin-radixin-moesin-binding phosphoprotein 50 in cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22448089&form=6&db=m Novel roles of peroxiredoxins in inflammation, cancer and innate immunity. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22475482&form=6&db=m Human peroxiredoxin 1 modulates TGF-?1-induced epithelial-mesenchymal transition through its peroxidase activity. causal interaction,unassigned 3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22609006&form=6&db=m Functional dissection of Nrf2-dependent phase II genes in vascular inflammation and endotoxic injury using Keap1 siRNA. causal interaction,ongoing research,unassigned 1,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22818443&form=6&db=m Conjugated linoleic acid synthesis-related protein proteasome subunit ? 5 (PSMA5) is increased by vaccenic acid treatment in goat mammary tissue. ongoing research,unassigned 1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22852132&form=6&db=m Comparative proteomic analysis of drug sodium iron chlorophyllin addition to Hep 3B cell line. therapeutic application,unassigned 1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22916164&form=6&db=m Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth. causal interaction,ongoing research,unassigned 3,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22976689&form=6&db=m Adult rhabdomyoma with oncocytic changes affecting the floor of the mouth: optical, immunohistochemical, and ultrastructural study. causal interaction,unassigned 1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22987634&form=6&db=m Peroxiredoxins, gerontogenes linking aging to genome instability and cancer. causal interaction,therapeutic application,unassigned 2,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23113308&form=6&db=m Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23186333&form=6&db=m Prx I suppresses K-ras-driven lung tumorigenesis by opposing redox-sensitive ERK/cyclin D1 pathway. causal interaction,therapeutic application,unassigned 3,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23271054&form=6&db=m The effect of peroxiredoxin 4 on fly physiology is a complex interplay of antioxidant and signaling functions. causal interaction,therapeutic application,unassigned 3,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23386615&form=6&db=m The tumor suppressor mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein. causal interaction,unassigned 2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23737084&form=6&db=m Expression of peroxiredoxins I and IV in multiple myeloma: association with immunoglobulin accumulation. diagnostic usage,ongoing research,unassigned 3,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23880827&form=6&db=m Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24023558&form=6&db=m Elevated prx1 provides resistance to docetaxel, but is not associated with predictive significance in lung cancer. diagnostic usage,ongoing research,unassigned 3,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24126619&form=6&db=m Autophagy sensitivity of neuroendocrine lung tumor cells. causal interaction,diagnostic usage,unassigned 3,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24234423&form=6&db=m Peroxiredoxin 2 is upregulated in colorectal cancer and contributes to colorectal cancer cells' survival by protecting cells from oxidative stress. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24649208&form=6&db=m Peroxiredoxin V: A candidate breast tumor marker of population specificity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24750185&form=6&db=m Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24801752&form=6&db=m Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KII? as anti-tumor strategy. causal interaction,unassigned 1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24862795&form=6&db=m Peroxiredoxin 2 expression is increased in neutrophils of patients with refractory cytopenia with multilineage dysplasia. causal interaction,unassigned 4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24920174&form=6&db=m Overexpression of peroxiredoxin 2 inhibits TGF-?1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24976757&form=6&db=m The role of peroxiredoxin II in chemoresistance of breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25162226&form=6&db=m Induction of peroxiredoxin 1 by hypoxia regulates heme oxygenase-1 via NF-?B in oral cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25232487&form=6&db=m Expression of peroxiredoxin 1 and 4 promotes human lung cancer malignancy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25339198&form=6&db=m Expression pattern of the PRDX2, RAB1A, RAB1B, RAB5A and RAB25 genes in normal and cancer cervical tissues. diagnostic usage,ongoing research,unassigned 4,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25368229&form=6&db=m Blue light activates phase 2 response proteins and slows growth of a431 epidermoid carcinoma xenografts. therapeutic application,unassigned 1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25434328&form=6&db=m Expression and clinical value of peroxiredoxin-1 in patients with pancreatic cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25471788&form=6&db=m Peroxiredoxin 2 is involved in vasculogenic mimicry formation by targeting VEGFR2 activation in colorectal cancer. ongoing research,unassigned 4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25484280&form=6&db=m Redox proteomics reveal stress responsive proteins linking peroxiredoxin-1 status in glioma to chemosensitivity and oxidative stress. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25579166&form=6&db=m Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma. causal interaction,therapeutic application,unassigned 1,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25607351&form=6&db=m Downregulation of peroxiredoxin-1 by ?-elemene enhances the radiosensitivity of lung adenocarcinoma xenografts. causal interaction,therapeutic application,unassigned 3,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25779674&form=6&db=m Peroxiredoxin 4: a novel secreted mediator of cancer induced osteoclastogenesis. causal interaction,unassigned 2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25854900&form=6&db=m Effects of 5'-azacytidine and alendronate on a hepatocellular carcinoma cell line: a proteomics perspective. ongoing research,unassigned 2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25875582&form=6&db=m The functional role of peroxiredoxin 3 in reactive oxygen species, apoptosis, and chemoresistance of cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25891757&form=6&db=m Improvement of Plasma Biomarkers after Switching Stroke Patients from Other Angiotensin II Type I Receptor Blockers to Olmesartan. causal interaction,diagnostic usage,unassigned 1,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26021759&form=6&db=m An important role for peroxiredoxin II in survival of A549 lung cancer cells resistant to gefitinib. causal interaction,ongoing research,unassigned 4,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26058145&form=6&db=m Momilactone sensitive proteins in Arabidopsis thaliana. unassigned - 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26091938&form=6&db=m FOXM1-Induced PRX3 Regulates Stemness and Survival of Colon Cancer Cells via Maintenance of Mitochondrial Function. diagnostic usage,ongoing research,unassigned 3,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26261544&form=6&db=m Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26410814&form=6&db=m Spirulina phycocyanin induces differential protein expression and apoptosis in SKOV-3 cells. causal interaction,therapeutic application,unassigned 1,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26461286&form=6&db=m Peroxiredoxin 1 knockdown sensitizes cancer cells to reactive oxygen species-generating drugs - an alternative approach for chemotherapy. therapeutic application,unassigned 4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26500057&form=6&db=m Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signaling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26528922&form=6&db=m Effective Killing of Cancer Cells Through ROS-Mediated Mechanisms by AMRI-59 Targeting Peroxiredoxin I. causal interaction,therapeutic application,unassigned 3,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26569310&form=6&db=m Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy. causal interaction,unassigned 4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26622762&form=6&db=m Peroxiredoxin 1 suppresses apoptosis via regulation of the apoptosis signal-regulating kinase 1 signaling pathway in human oral leukoplakia. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26631806&form=6&db=m Threonine modulates immune response, antioxidant status and gene expressions of antioxidant enzymes and antioxidant-immune-cytokine-related signaling molecules in juvenile blunt snout bream (Megalobrama amblycephala). therapeutic application,unassigned 1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26636537&form=6&db=m Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma. causal interaction,ongoing research,unassigned 4,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26686468&form=6&db=m Enhanced targeting of mitochondrial peroxide defense by the combined use of thiosemicarbazones and inhibitors of thioredoxin reductase. causal interaction,diagnostic usage,unassigned 3,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26689287&form=6&db=m PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26699993&form=6&db=m Re: Peroxiredoxin 4: A Novel Secreted Mediator of Cancer Induced Osteoclastogenesis. causal interaction,therapeutic application,unassigned 2,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26707944&form=6&db=m Marginal zinc intake reduces the protective effect of lactation on mammary gland carcinogenesis in a DMBA-induced tumor model in mice. causal interaction,therapeutic application,unassigned 4,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26722077&form=6&db=m Loss of Peroxiredoxin Expression Is Associated with an Aggressive Phenotype in Pancreatic Adenocarcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26866938&form=6&db=m Peroxiredoxin II is essential for maintaining stemness by redox regulation in liver cancer cells. diagnostic usage,ongoing research,unassigned 3,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26975474&form=6&db=m Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27100486&form=6&db=m Expression and function of peroxiredoxins in gynecological malignancies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27158373&form=6&db=m Identification and verification of PRDX1 as an inflammation marker for colorectal cancer progression. causal interaction,diagnostic usage,unassigned 1,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27306414&form=6&db=m Overexpression of Peroxiredoxin 6 Protects Neoplastic Cells against Apoptosis in Canine Haemangiosarcoma. unassigned - 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27517622&form=6&db=m Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis. causal interaction,ongoing research,unassigned 4,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27602166&form=6&db=m PRDX2 protects hepatocellular carcinoma SMMC-7721 cells from oxidative stress. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27629822&form=6&db=m Catalytic Thr or Ser Residue Modulates Structural Switches in 2-Cys Peroxiredoxin by Distinct Mechanisms. diagnostic usage,therapeutic application,unassigned 2,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27653015&form=6&db=m Peroxiredoxin 1 - an antioxidant enzyme in cancer. ongoing research,unassigned 3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27725259&form=6&db=m Differential protein expression using proteomics from a crustacean brine shrimp (Artemia sinica) under CO2-driven seawater acidification. unassigned - 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27894099&form=6&db=m Peroxiredoxin 2 is essential for maintaining cancer stem cell-like phenotype through activation of Hedgehog signaling pathway in colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28125800&form=6&db=m Peroxiredoxin 2 is associated with colorectal cancer progression and poor survival of patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28240739&form=6&db=m Tubular Peroxiredoxin 3 as a Predictor of Renal Recovery from Acute Tubular Necrosis in Patients with Chronic Kidney Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28351321&form=6&db=m Mammalian target of rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by phorbol-myristate-acetate and oncostatin-M in glioblastoma cells. ongoing research,unassigned 1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28391978&form=6&db=m Recombinant protein transduction domain-Cu/Zn superoxide dismutase alleviates bone cancer pain via peroxiredoxin 4 modulation and antioxidation. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28432271&form=6&db=m Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28471203&form=6&db=m [Ascites May Provide Useful Information for Diagnosis of Ovarian Cancer]. diagnostic usage,unassigned 1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28659575&form=6&db=m Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28683851&form=6&db=m Survival of APC-mutant colorectal cancer cells requires interaction between tankyrase and a thiol peroxidase, peroxiredoxin II. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28717468&form=6&db=m Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I. causal interaction,unassigned 3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28765537&form=6&db=m PRDX2 in Myocyte Hypertrophy and Survival is Mediated by TLR4 in Acute Infarcted Myocardium. causal interaction,unassigned 3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28849259&form=6&db=m Nrf2-peroxiredoxin I axis in polymorphous adenocarcinoma is associated with low matrix metalloproteinase 2 level. causal interaction,unassigned 3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29088845&form=6&db=m Nicotine suppresses apoptosis by regulating ?7nAChR/Prx1 axis in oral precancerous lesions. unassigned - 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29130098&form=6&db=m Ursodeoxycholic acid suppresses epithelial-mesenchymal transition and cancer stem cell formation by reducing the levels of peroxiredoxin II and reactive oxygen species in pancreatic cancer cells. ongoing research,unassigned 3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29133261&form=6&db=m Dual inhibition of BRD4 and PI3K by SF2523 suppresses human prostate cancer cell growth in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29237274&form=6&db=m Peroxiredoxin Involvement in the Initiation and Progression of Human Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29348788&form=6&db=m The Role of Redox-Regulating Enzymes in Inoperable Breast Cancers Treated with Neoadjuvant Chemotherapy. causal interaction,diagnostic usage,unassigned 2,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29541251&form=6&db=m Overexpression of peroxiredoxin-3 and -5 is a potential biomarker for prognosis in endometrial cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29545070&form=6&db=m Expression of reactive species related genes is associated with patient survival in luminal B breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29582423&form=6&db=m A PRDX1-p38? heterodimer amplifies MET-driven invasion of IDH-wildtype and IDH-mutant gliomas. ongoing research,unassigned 1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29673884&form=6&db=m Peroxiredoxin 1 promoted tumor metastasis and angiogenesis in colorectal cancer. causal interaction,diagnostic usage,unassigned 4,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29691673&form=6&db=m Multi-panel assay of serum autoantibodies in colorectal cancer. diagnostic usage,ongoing research,unassigned 3,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29773556&form=6&db=m PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase. unassigned - 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29908016&form=6&db=m Peroxiredoxin 1 (PRDX1) Suppresses Progressions and Metastasis of Osteosarcoma and Fibrosarcoma of Bone. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30013444&form=6&db=m The Combination Of Weak Expression Of PRDX4 And Very High MIB-1 Labelling Index Independently Predicts Shorter Disease-free Survival In Stage I Lung Adenocarcinoma. therapeutic application,unassigned 3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30020823&form=6&db=m Epigenetic silencing of the tumor suppressor genes SPI1, PRDX2, KLF4, DLEC1, and DAPK1 in childhood and adolescent lymphomas. diagnostic usage,ongoing research,unassigned 3,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30177619&form=6&db=m Peroxiredoxin II Regulates Cancer Stem Cells and Stemness-Associated Properties of Cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30214590&form=6&db=m Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30287919&form=6&db=m Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents. ongoing research,unassigned 3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30341415&form=6&db=m MicroRNA-122 negatively associates with peroxiredoxin-II expression in human gefitinib-resistant lung cancer stem cells. ongoing research,unassigned 2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30486489&form=6&db=m Piecing Together How Peroxiredoxins Maintain Genomic Stability. unassigned - 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30568461&form=6&db=m Prognostic roles of mRNA expression of peroxiredoxins in lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30611866&form=6&db=m Prx2 links ROS homeostasis to stemness of cancer stem cells. causal interaction,unassigned 4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30661989&form=6&db=m Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects. unassigned - 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30747220&form=6&db=m Peroxiredoxin2 downregulation enhances hepatocellular carcinoma proliferation and migration, and is associated with unfavorable prognosis in patients. diagnostic usage,ongoing research,unassigned 1,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30784599&form=6&db=m Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-?-Induced Apoptosis via Different Routes. causal interaction,unassigned 2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30824188&form=6&db=m SF2523 inhibits human chondrosarcoma cell growth in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30981892&form=6&db=m Tumor protein D52 (isoform 3) interacts with and promotes peroxidase activity of Peroxiredoxin 1 in prostate cancer cells implicated in cell growth and migration. diagnostic usage,ongoing research,unassigned 3,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31018997&form=6&db=m SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,1,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31101821&form=6&db=m Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis. causal interaction,unassigned 1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31176251&form=6&db=m Small interfering RNA targeting of peroxiredoxin? gene enhances formaldehyde-induced toxicity in bone marrow cells isolated from BALB/c mice. causal interaction,unassigned 3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31262894&form=6&db=m Peroxiredoxin V Reduces ?-Lapachone-induced Apoptosis of Colon Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31280208&form=6&db=m Peroxiredoxin V Inhibits Emodin-induced Gastric Cancer Cell Apoptosis via the ROS/Bcl2 Pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,1 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31298537&form=6&db=m Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1. causal interaction,therapeutic application,unassigned 3,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31311441&form=6&db=m PRDX4 and Its Roles in Various Cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31360686&form=6&db=m The Role of Peroxiredoxin Family in Cancer Signaling. causal interaction,ongoing research,unassigned 1,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31470801&form=6&db=m Expression of thioredoxin 1 and peroxiredoxins in squamous cervical carcinoma and its predictive role in NACT. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31500275&form=6&db=m Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31533285&form=6&db=m Validation of Cadherin HAV6 Peptide in the Transient Modulation of the Blood-Brain Barrier for the Treatment of Brain Tumors. causal interaction,therapeutic application,unassigned 2,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31567534&form=6&db=m Reactive oxygen species-regulating proteins peroxiredoxin 2 and thioredoxin, and glyceraldehyde-3-phosphate dehydrogenase are differentially abundant in induced sputum from smokers with lung cancer or asbestos exposure. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31636803&form=6&db=m Peroxiredoxin III Protects Tumor Suppressor PTEN from Oxidation by 15-Hydroperoxy-eicosatetraenoic Acid. ongoing research,unassigned 2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31807984&form=6&db=m Prdx2 Upregulation Promotes the Growth and Survival of Gastric Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31899687&form=6&db=m PRDX5 as a novel binding partner in Nrf2-mediated NSCLC progression under oxidative stress. causal interaction,unassigned 4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31965757&form=6&db=m AdipoRon, a new therapeutic prospect for Duchenne muscular dystrophy. causal interaction,unassigned 1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32269626&form=6&db=m PRDX4 overexpression is associated with poor prognosis in gastric cancer. causal interaction,unassigned 4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32292340&form=6&db=m Danhong Injection Protects Hemorrhagic Brain by Increasing Peroxiredoxin 1 in Aged Rats. unassigned - 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32337219&form=6&db=m Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells. causal interaction,ongoing research,unassigned 1,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32339330&form=6&db=m PCAT6 mediates cellular biological functions in gastrointestinal stromal tumor via upregulation of PRDX5 and activation of Wnt pathway. causal interaction,unassigned 2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32448013&form=6&db=m Genetic Regulation of Redox Balance in ?-Thalassemia Trait. diagnostic usage,ongoing research,unassigned 3,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32655804&form=6&db=m Peroxiredoxin 4 promotes embryonal hepatoblastoma cell migration but induces fetal cell differentiation. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32692719&form=6&db=m PRDX2 removal inhibits the cell cycle and autophagy in colorectal cancer cells. diagnostic usage,ongoing research,unassigned 1,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32736685&form=6&db=m Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32908916&form=6&db=m PRDX2 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer In Vitro and In Vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32908958&form=6&db=m The Synergistic Effect of an ATP-Competitive Inhibitor of mTOR and Metformin on Pancreatic Tumor Growth. causal interaction,therapeutic application,unassigned 4,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32929349&form=6&db=m Celastrol induces ROS-mediated apoptosis via directly targeting peroxiredoxin-2 in gastric cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33017884&form=6&db=m Long Non-coding RNA CASC15 Promotes Intrahepatic Cholangiocarcinoma Possibly through Inducing PRDX2/PI3K/AKT Axis. diagnostic usage,therapeutic application,unassigned 3,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33072014&form=6&db=m Identification and Analysis of the Tegument Protein and Excretory-Secretory Products of the Carcinogenic Liver Fluke Clonorchis sinensis. diagnostic usage,unassigned 1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33182509&form=6&db=m Upregulation of Peroxiredoxin-2 in Well-Differentiated Pancreatic Neuroendocrine Tumors and Its Utility as a Biomarker for Predicting the Response to Everolimus. diagnostic usage,ongoing research,unassigned 3,1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33332365&form=6&db=m Peroxiredoxin 2 is highly expressed in human oral squamous cell carcinoma cells and is upregulated by human papillomavirus oncoproteins and arecoline, promoting proliferation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33416106&form=6&db=m ROS?mediated hypomethylation of PRDX5 promotes STAT3 binding and activates the Nrf2 signaling pathway in NSCLC. causal interaction,diagnostic usage,unassigned 2,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33440265&form=6&db=m Identification and functional analysis of senescence-associated secretory phenotype of premature senescent hepatocytes induced by hexavalent chromium. causal interaction,unassigned 1,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33631924&form=6&db=m Identification of peroxiredoxin 6 as a potential lung-adenocarcinoma biomarker for predicting chemotherapy response by proteomic analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33747258&form=6&db=m Prognostic Value of Peroxiredoxin-1 Expression in Patients with Solid Tumors: a Meta-Analysis of Cohort Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33791345&form=6&db=m PRDX2 Protects Against Atherosclerosis by Regulating the Phenotype and Function of the Vascular Smooth Muscle Cell. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33813388&form=6&db=m Peroxiredoxin V Silencing Elevates Susceptibility to Doxorubicin-induced Cell Apoptosis via ROS-dependent Mitochondrial Dysfunction in AGS Gastric Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33819194&form=6&db=m The critical role of peroxiredoxin-2 in colon cancer stem cells. causal interaction,unassigned 2,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33917763&form=6&db=m Genetic Inactivation of Peroxiredoxin-I Impairs the Growth of Human Pancreatic Cancer Cells. causal interaction,unassigned 4,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33969595&form=6&db=m Peroxiredoxin 5 is involved in cancer cell invasion and tumor growth of oral squamous cell carcinoma. causal interaction,ongoing research,unassigned 4,3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34076143&form=6&db=m Nicotine promotes the development of oral leukoplakia via regulating peroxiredoxin 1 and its binding proteins. causal interaction,unassigned 3,0 1.11.1.24 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34389806&form=6&db=m Peroxiredoxin-1 Tyr194 phosphorylation regulates LOX-dependent extracellular matrix remodelling in breast cancer. causal interaction,ongoing research,unassigned 1,1,0 1.11.1.24 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22302711&form=6&db=m The antioxidant enzyme peroxiredoxin and its protective role in neurological disorders. ongoing research,unassigned 2,0 1.11.1.24 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32002772&form=6&db=m Effects of Peroxiredoxin 2 in Neurological Disorders: A Review of its Molecular Mechanisms. ongoing research,therapeutic application,unassigned 4,3,0 1.11.1.24 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12943237&form=6&db=m Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, is under-expressed in Down syndrome fetal brains. ongoing research,unassigned 3,0 1.11.1.24 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18262354&form=6&db=m Silencing of peroxiredoxin 3 and peroxiredoxin 5 reveals the role of mitochondrial peroxiredoxins in the protection of human neuroblastoma SH-SY5Y cells toward MPP(+). causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 1.11.1.24 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18751929&form=6&db=m The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 1.11.1.24 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22232637&form=6&db=m Peroxiredoxin I regulates the component expression of ?-secretase complex causing the Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 1.11.1.24 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28840510&form=6&db=m Cypermethrin Activates Autophagosome Formation Albeit Inhibits Autophagy Owing to Poor Lysosome Quality: Relevance to Parkinson's Disease. ongoing research,therapeutic application,unassigned 2,3,0 1.11.1.24 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12401949&form=6&db=m Numerous proteins in Mammalian cells are prone to iron-dependent oxidation and proteasomal degradation. unassigned - 1.11.1.24 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12650976&form=6&db=m Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders. ongoing research,unassigned 1,0 1.11.1.24 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18491044&form=6&db=m Peroxiredoxin 2 is involved in the neuroprotective effects of PACAP in cultured cerebellar granule neurons. causal interaction,therapeutic application,unassigned 4,4,0 1.11.1.24 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21674491&form=6&db=m Peroxiredoxin distribution in the mouse brain with emphasis on neuronal populations affected in neurodegenerative disorders. ongoing research,unassigned 1,0 1.11.1.24 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22136616&form=6&db=m Posttranslational modification of cysteine in redox signaling and oxidative stress: focus on s-glutathionylation. unassigned - 1.11.1.24 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24496069&form=6&db=m Hyperhomocysteinemia and Bleomycin Hydrolase Modulate the Expression of Mouse Brain Proteins Involved in Neurodegeneration. unassigned - 1.11.1.24 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28871473&form=6&db=m Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells. causal interaction,therapeutic application,unassigned 3,1,0 1.11.1.24 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23602274&form=6&db=m Peroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant that regulates NF-?B-mediated iNOS induction and microglial activation. causal interaction,therapeutic application,unassigned 4,2,0 1.11.1.24 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33515567&form=6&db=m Modulation of vascular integrity and neuroinflammation by peroxiredoxin 4 following cerebral ischemia-reperfusion injury. causal interaction,unassigned 4,0 1.11.1.24 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23477499&form=6&db=m PEROXIREDOXIN 4 PROTECTS AGAINST NONALCOHOLIC STEATOHEPATITIS AND TYPE 2 DIABETES IN A NONGENETIC MOUSE MODEL. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 1.11.1.24 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27035833&form=6&db=m Overexpression of Peroxiredoxin 4 Affects Intestinal Function in a Dietary Mouse Model of Nonalcoholic Fatty Liver Disease. ongoing research,unassigned 3,0 1.11.1.24 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29341349&form=6&db=m Peroxiredoxin 4 (PRDX4): Its critical in vivo roles in animal models of metabolic syndrome ranging from atherosclerosis to nonalcoholic fatty liver disease. ongoing research,unassigned 2,0 1.11.1.24 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31505325&form=6&db=m Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling. causal interaction,therapeutic application,unassigned 1,1,0 1.11.1.24 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24254933&form=6&db=m Expression of hepatic antioxidant enzymes in non-obese type-2 diabetic Goto-Kakizaki rats. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26910225&form=6&db=m Effects of Obesity on Perivascular Adipose Tissue Vasorelaxant Function: Nitric Oxide, Inflammation and Elevated Systemic Blood Pressure. diagnostic usage,unassigned 3,0 1.11.1.24 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27523322&form=6&db=m Plekhs1 and Prdx3 are candidate genes responsible for mild hyperglycemia associated with obesity in a new animal model of F344-fa-nidd6 rat. causal interaction,unassigned 1,0 1.11.1.24 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28274171&form=6&db=m Differential representation of liver proteins in obese human subjects suggests novel biomarkers and promising targets for drug development in obesity. unassigned - 1.11.1.24 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30980996&form=6&db=m Peroxiredoxin 4 levels in patients with PCOS and/or obesity. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 1.11.1.24 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33727589&form=6&db=m Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2. causal interaction,unassigned 3,0 1.11.1.24 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34521981&form=6&db=m Author Correction: Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2. causal interaction,unassigned 2,0 1.11.1.24 Obesity, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30980996&form=6&db=m Peroxiredoxin 4 levels in patients with PCOS and/or obesity. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 1.11.1.24 Opisthorchiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28429227&form=6&db=m Secretion of Thioredoxin Peroxidase Protein of Cat Liver Fluke Opisthorchis felineus during Modeling of Experimental Opisthorchiasis. ongoing research,unassigned 2,0 1.11.1.24 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12417342&form=6&db=m Expression and regulation of peroxiredoxin 5 in human osteoarthritis. ongoing research,unassigned 4,0 1.11.1.24 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26797130&form=6&db=m Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes. causal interaction,therapeutic application,unassigned 3,1,0 1.11.1.24 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27052304&form=6&db=m The protective role of autophagy in experimental osteoarthritis, and the therapeutic effects of Torin 1 on osteoarthritis by activating autophagy. ongoing research,therapeutic application,unassigned 3,2,0 1.11.1.24 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27301478&form=6&db=m Intra-articular injection of Torin 1 reduces degeneration of articular cartilage in a rabbit osteoarthritis model. ongoing research,therapeutic application,unassigned 4,2,0 1.11.1.24 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21137073&form=6&db=m Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics. causal interaction,therapeutic application,unassigned 2,3,0 1.11.1.24 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23911960&form=6&db=m Proteomics study of open biopsy samples identifies peroxiredoxin 2 as a predictive biomarker of response to induction chemotherapy in osteosarcoma. ongoing research,therapeutic application,unassigned 3,3,0 1.11.1.24 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28314261&form=6&db=m Peroxiredoxin Expression of Human Osteosarcoma Cells Is Influenced by Cold Atmospheric Plasma Treatment. diagnostic usage,unassigned 3,0 1.11.1.24 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29492195&form=6&db=m Peroxiredoxin-1 promotes cell proliferation and metastasis through enhancing Akt/mTOR in human osteosarcoma cells. causal interaction,ongoing research,unassigned 2,4,0 1.11.1.24 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29908016&form=6&db=m Peroxiredoxin 1 (PRDX1) Suppresses Progressions and Metastasis of Osteosarcoma and Fibrosarcoma of Bone. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34113126&form=6&db=m ?-Elemene Enhances the Sensitivity of Osteosarcoma Cells to Doxorubicin via Downregulation of Peroxiredoxin-1. diagnostic usage,ongoing research,unassigned 3,2,0 1.11.1.24 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27318370&form=6&db=m The role of peroxiredoxin I in cisplatin-induced ototoxicity. ongoing research,unassigned 3,0 1.11.1.24 Out-of-Hospital Cardiac Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26977736&form=6&db=m The Combination of Biomarkers for Prognostication of Long-Term Outcome in Patients Treated with Mild Hypothermia After Out-of-Hospital Cardiac Arrest-A Pilot Study. diagnostic usage,unassigned 1,0 1.11.1.24 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21980378&form=6&db=m Proteomic analysis of ovarian cancer proximal fluids: validation of elevated peroxiredoxin 1 in patient peripheral circulation. causal interaction,diagnostic usage,unassigned 4,3,0 1.11.1.24 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22843871&form=6&db=m Down-regulation of 8-Hydroxydeoxyguanosine and Peroxiredoxin II in the Pathogenesis of Endometriosis-associated Ovarian Cancer. diagnostic usage,ongoing research,unassigned 1,2,0 1.11.1.24 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23564483&form=6&db=m Peroxiredoxin III protein expression is associated with platinum resistance in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.11.1.24 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30104402&form=6&db=m The prognostic values of the peroxiredoxins family in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 1.11.1.24 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31311441&form=6&db=m PRDX4 and Its Roles in Various Cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 1.11.1.24 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31559796&form=6&db=m Peroxiredoxin-1 as a prognostic factor in patients with ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 1.11.1.24 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33637694&form=6&db=m CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129. ongoing research,unassigned 3,0 1.11.1.24 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17982661&form=6&db=m Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine. diagnostic usage,therapeutic application,unassigned 4,2,0 1.11.1.24 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19357035&form=6&db=m Comparative proteomic analysis of differentially expressed proteins in human pancreatic cancer tissue. causal interaction,diagnostic usage,unassigned 2,2,0 1.11.1.24 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25426613&form=6&db=m Peroxiredoxin 1 Promotes Pancreatic Cancer Cell Invasion by Modulating p38 MAPK Activity. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 1.11.1.24 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25434328&form=6&db=m Expression and clinical value of peroxiredoxin-1 in patients with pancreatic cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 1.11.1.24 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29130098&form=6&db=m Ursodeoxycholic acid suppresses epithelial-mesenchymal transition and cancer stem cell formation by reducing the levels of peroxiredoxin II and reactive oxygen species in pancreatic cancer cells. ongoing research,unassigned 3,0 1.11.1.24 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29190947&form=6&db=m Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer. causal interaction,unassigned 3,0 1.11.1.24 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30464602&form=6&db=m Peroxiredoxin 1 silencing inhibited the growth and promoted apoptosis of pancreatic cancer cells via targeting FOXO3 gene. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 1.11.1.24 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15604267&form=6&db=m Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry. diagnostic usage,unassigned 3,0 1.11.1.24 Papillomavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33332365&form=6&db=m Peroxiredoxin 2 is highly expressed in human oral squamous cell carcinoma cells and is upregulated by human papillomavirus oncoproteins and arecoline, promoting proliferation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 1.11.1.24 Parasitemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28595515&form=6&db=m Trans-sialidase overcomes many antigens to be used as a vaccine candidate against Trypanosoma cruzi. causal interaction,diagnostic usage,unassigned 2,3,0 1.11.1.24 Parasitic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16540402&form=6&db=m A mosquito 2-Cys peroxiredoxin protects against nitrosative and oxidative stresses associated with malaria parasite infection. causal interaction,therapeutic application,unassigned 2,1,0 1.11.1.24 Paratuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11169225&form=6&db=m Elevated antibody responses in patients with Crohn's disease against a 14-kDa secreted protein purified from Mycobacterium avium subsp. paratuberculosis. diagnostic usage,unassigned 3,0 1.11.1.24 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18003920&form=6&db=m S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease. causal interaction,unassigned 2,0 1.11.1.24 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18250162&form=6&db=m Oxidative Modification of Peroxiredoxin Is Associated with Drug-induced Apoptotic Signaling in Experimental Models of Parkinson Disease. therapeutic application,unassigned 1,0 1.11.1.24 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19119913&form=6&db=m Proteomic Profiling of the Insoluble Pellets of the Transected Rat Spinal Cord. unassigned - 1.11.1.24 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23442153&form=6&db=m Peroxiredoxin 5 links mitochondrial redox signalling with calcium dynamics: impact on Parkinson's disease. unassigned - 1.11.1.24 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34173170&form=6&db=m Involvement of Peroxiredoxin-3, Thioredoxin-2, and Protein Deglycase-1 in Cypermethrin-Induced Parkinsonism. causal interaction,unassigned 1,0 1.11.1.24 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19108621&form=6&db=m Production of polyclonal antibody against alkyl hydroperoxide reductase of Helicobacter pylori and its antigenicity. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 1.11.1.24 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29707240&form=6&db=m Dual function of peroxiredoxin I in lipopolysaccharide-induced osteoblast apoptosis via reactive oxygen species and the apoptosis signal-regulating kinase 1 signaling pathway. therapeutic application,unassigned 1,0 1.11.1.24 Persistent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25033301&form=6&db=m Leishmania amazonensis amastigotes highly express a tryparedoxin peroxidase isoform that increases parasite resistance to macrophage antimicrobial defenses and Fosters parasite virulence. therapeutic application,unassigned 1,0 1.11.1.24 Plasmablastic Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18565146&form=6&db=m Peroxiredoxin I is differentially expressed in multiple myelomas and in plasmablastic lymphomas. causal interaction,unassigned 2,0 1.11.1.24 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18219526&form=6&db=m Peroxiredoxin v contributes to antioxidant defense of lung epithelial cells. causal interaction,ongoing research,unassigned 1,4,0 1.11.1.24 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21239607&form=6&db=m Aggravation of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice Lacking Peroxiredoxin I. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.11.1.24 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23019345&form=6&db=m Peroxiredoxin I null mice exhibits reduced acute lung inflammation following ozone exposure. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 1.11.1.24 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23565988&form=6&db=m Increased annexin A1 and A2 levels in bronchoalveolar lavage fluid are associated with resistance to respiratory disease in beef calves. diagnostic usage,unassigned 1,0 1.11.1.24 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27858147&form=6&db=m Evolution and function of the Mycoplasma hyopneumoniae peroxiredoxin, a 2-Cys-like enzyme with a single Cys residue. therapeutic application,unassigned 1,0 1.11.1.24 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31279222&form=6&db=m The effect of exposure time and concentration of airborne PM2.5 on lung injury in mice: A transcriptome analysis. causal interaction,unassigned 4,0 1.11.1.24 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24098506&form=6&db=m Downregulated Expression of Peroxiredoxin 4 in Granulosa Cells from Polycystic Ovary Syndrome. ongoing research,unassigned 4,0 1.11.1.24 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30871530&form=6&db=m Plasma level of peroxiredoxin 3 in patients with polycystic ovarian syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 1.11.1.24 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30980996&form=6&db=m Peroxiredoxin 4 levels in patients with PCOS and/or obesity. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 1.11.1.24 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20716930&form=6&db=m Role of peroxiredoxin III in the pathogenesis of pre-eclampsia as evidenced in mice. causal interaction,ongoing research,unassigned 1,2,0 1.11.1.24 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33421846&form=6&db=m Association of glutamate cystein ligase (GCL) activity Peroxiredoxin 4 (prxR4) and apelin levels in women with preeclampsia. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 1.11.1.24 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26497580&form=6&db=m Rapamycin-resistant and torin-sensitive mTOR signaling promotes the survival and proliferation of leukemic cells. causal interaction,unassigned 1,0 1.11.1.24 Prediabetic State http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27303935&form=6&db=m Increased peroxiredoxin 4 levels in patients with prediabetes compared to normal glucose tolerance subjects. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 1.11.1.24 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11509333&form=6&db=m Induction of peroxiredoxin gene expression by oxygen in lungs of newborn primates. unassigned - 1.11.1.24 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29113303&form=6&db=m Mitochondrion-associated protein peroxiredoxin 3 promotes benign prostatic hyperplasia through autophagy suppression and pyroptosis activation. causal interaction,unassigned 2,0 1.11.1.24 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23880827&form=6&db=m Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 1.11.1.24 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21343392&form=6&db=m Peroxiredoxin 1 controls prostate cancer growth through Toll-like receptor 4-dependent regulation of tumor vasculature. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 1.11.1.24 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21539911&form=6&db=m Peroxiredoxin 2 in the nucleus and cytoplasm distinctly regulates androgen receptor activity in prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,3,0 1.11.1.24 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22710126&form=6&db=m MicroRNA-23b downregulates peroxiredoxin III in human prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 1.11.1.24 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23880827&form=6&db=m Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 1.11.1.24 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24281119&form=6&db=m The nrf1 and nrf2 balance in oxidative stress regulation and androgen signaling in prostate cancer cells. ongoing research,unassigned 2,0 1.11.1.24 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29133261&form=6&db=m Dual inhibition of BRD4 and PI3K by SF2523 suppresses human prostate cancer cell growth in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 1.11.1.24 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30981892&form=6&db=m Tumor protein D52 (isoform 3) interacts with and promotes peroxidase activity of Peroxiredoxin 1 in prostate cancer cells implicated in cell growth and migration. diagnostic usage,ongoing research,unassigned 3,1,0 1.11.1.24 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31311441&form=6&db=m PRDX4 and Its Roles in Various Cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 1.11.1.24 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15277208&form=6&db=m Loss of PKC-delta alters cardiac metabolism. unassigned - 1.11.1.24 Pseudorabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34260286&form=6&db=m Peroxiredoxin 1 Interacts with TBK1/IKK? and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity. causal interaction,therapeutic application,unassigned 3,1,0 1.11.1.24 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20363977&form=6&db=m Ezrin, maspin, peroxiredoxin 2, and heat shock protein 27: potential targets of a streptococcal-induced autoimmune response in psoriasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,3 1.11.1.24 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23499777&form=6&db=m Overexpression of peroxiredoxin 2 in pterygium. A proteomic approach. causal interaction,therapeutic application,unassigned 2,2,0 1.11.1.24 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24152995&form=6&db=m Peroxiredoxin I and II in human eyes: cellular distribution and association with pterygium and DNA damage. causal interaction,ongoing research,unassigned 1,4,0 1.11.1.24 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25221425&form=6&db=m Proteomic analysis in pterygium; upregulated protein expression of ALDH3A1, PDIA3, and PRDX2. unassigned - 1.11.1.24 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28489720&form=6&db=m Expression of Peroxiredoxin 2 and Vascular Endothelial Growth Factor Receptor 2 in Pterygium. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 1.11.1.24 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25036363&form=6&db=m Susceptibility to COPD: differential proteomic profiling after acute smoking. causal interaction,unassigned 2,0 1.11.1.24 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32231717&form=6&db=m Peroxiredoxins and Immune Infiltrations in Colon Adenocarcinoma: Their Negative Correlations and Clinical Significances, an In Silico Analysis. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 1.11.1.24 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21239607&form=6&db=m Aggravation of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice Lacking Peroxiredoxin I. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.11.1.24 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24053922&form=6&db=m [Expression of peroxiredoxin I in the rats exposed to silica]. ongoing research,unassigned 3,0 1.11.1.24 Rabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21532319&form=6&db=m Proteomic profiles of mouse neuro N2a cells infected with variant virulence of rabies viruses. diagnostic usage,therapeutic application,unassigned 1,2,0 1.11.1.24 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20732753&form=6&db=m Role of peroxiredoxin I in rectal cancer and related to p53 status. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 1.11.1.24 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28240739&form=6&db=m Tubular Peroxiredoxin 3 as a Predictor of Renal Recovery from Acute Tubular Necrosis in Patients with Chronic Kidney Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 1.11.1.24 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21905220&form=6&db=m Increased expression of peroxiredoxin 1 and identification of a novel lipid-metabolizing enzyme in the early phase of liver ischemia reperfusion injury. causal interaction,therapeutic application,unassigned 3,1,0 1.11.1.24 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33515567&form=6&db=m Modulation of vascular integrity and neuroinflammation by peroxiredoxin 4 following cerebral ischemia-reperfusion injury. causal interaction,unassigned 4,0 1.11.1.24 Retinal Detachment http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26664739&form=6&db=m Proteomic Analysis of the Vitreous following Experimental Retinal Detachment in Rabbits. diagnostic usage,unassigned 3,0 1.11.1.24 Rhabdomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22976689&form=6&db=m Adult rhabdomyoma with oncocytic changes affecting the floor of the mouth: optical, immunohistochemical, and ultrastructural study. causal interaction,unassigned 1,0 1.11.1.24 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13614732&form=6&db=m [Investigation of the spreading of rheumatic disease; incidence of rheumatic disease in the members of a Bus and Streetcar Society of Torin; clinical & radiological findings.] unassigned - 1.11.1.24 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12373774&form=6&db=m Bronchoalveolar lavage fluid protein composition in patients with sarcoidosis and idiopathic pulmonary fibrosis: a two-dimensional electrophoretic study. causal interaction,unassigned 3,0 1.11.1.24 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18069416&form=6&db=m A quantitative proteomic analysis of soluble bronchoalveolar fluid proteins from patients with sarcoidosis and chronic beryllium disease. diagnostic usage,unassigned 3,0 1.11.1.24 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22837380&form=6&db=m A Novel Sarcoidosis Risk Locus for Europeans on Chromosome 11q13.1. diagnostic usage,unassigned 3,0 1.11.1.24 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33480647&form=6&db=m Augmented Antitumor Activity for Novel Dual PI3K/BDR4 Inhibitors, SF2523 and SF1126 in Ewing Sarcoma. therapeutic application,unassigned 4,0 1.11.1.24 Sarcoma, Kaposi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12963914&form=6&db=m Expression of peroxiredoxin II in vascular tumors of the skin: a novel vascular marker of endothelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.11.1.24 Scabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23875925&form=6&db=m Characterisation and analysis of thioredoxin peroxidase as a potential antigen for the serodiagnosis of sarcoptic mange in rabbits by dot-ELISA. diagnostic usage,unassigned 2,0 1.11.1.24 Schistosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075328&form=6&db=m Biochemical characterization of 2-Cys peroxiredoxins from Schistosoma mansoni. unassigned - 1.11.1.24 Schistosomiasis mansoni http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19439374&form=6&db=m Biomphalaria glabrata peroxiredoxin: Effect of Schistosoma mansoni infection on differential gene regulation. ongoing research,unassigned 2,0 1.11.1.24 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17309887&form=6&db=m Autoantibody against peroxiredoxin I, an antioxidant enzyme, in patients with systemic sclerosis: possible association with oxidative stress. diagnostic usage,ongoing research,unassigned 2,3,0 1.11.1.24 Scurvy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24150425&form=6&db=m The role of ascorbate in protein folding. ongoing research,unassigned 2,0 1.11.1.24 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21083423&form=6&db=m Sulfiredoxin Protects Mice from Lipopolysaccharide-Induced Endotoxic Shock. causal interaction,unassigned 1,0 1.11.1.24 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21283059&form=6&db=m Circulating levels of Peroxiredoxin 4 as a Novel Biomarker of Oxidative Stress in Patients with Sepsis. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22003971&form=6&db=m A novel anti-peroxiredoxin autoantibody in patients with Kawasaki disease. causal interaction,diagnostic usage,unassigned 1,3,0 1.11.1.24 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30185517&form=6&db=m Targeting Peroxiredoxin 1 by a Curcumin Analogue, AI-44, Inhibits NLRP3 Inflammasome Activation and Attenuates Lipopolysaccharide-Induced Sepsis in Mice. ongoing research,therapeutic application,unassigned 1,2,0 1.11.1.24 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31719759&form=6&db=m Increased circulating peroxiredoxin-4 in sepsis model rats involves secretion from hepatocytes and is mitigated by GYY4137. diagnostic usage,ongoing research,unassigned 3,4,0 1.11.1.24 Severe Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19323035&form=6&db=m Differential expression of aldolase, alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from dengue fever and dengue hemorrhagic fever patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 1.11.1.24 Shock, Cardiogenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27142532&form=6&db=m Peroxiredoxin 1 induces inflammatory cytokine response and predicts outcome of cardiogenic shock patients necessitating extracorporeal membrane oxygenation: an observational cohort study and translational approach. causal interaction,therapeutic application,unassigned 3,3,0 1.11.1.24 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32423810&form=6&db=m Peroxiredoxin-1 aggravates lipopolysaccharide-induced septic shock via promoting inflammation. therapeutic application,unassigned 2,0 1.11.1.24 Silicosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33535333&form=6&db=m [Differential expression of PRDX4 in alveolar macrophages of patients with silicosis]. diagnostic usage,ongoing research,unassigned 2,4,0 1.11.1.24 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32736685&form=6&db=m Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 1.11.1.24 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26003307&form=6&db=m Expression of Peroxiredoxin 1 After Traumatic Spinal Cord Injury in Rats. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 1.11.1.24 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10840156&form=6&db=m Peroxiredoxin I expression in oral cancer: a potential new tumor marker. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 1.11.1.24 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25162226&form=6&db=m Induction of peroxiredoxin 1 by hypoxia regulates heme oxygenase-1 via NF-?B in oral cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 1.11.1.24 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26722300&form=6&db=m Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-?B in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 1.11.1.24 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27966448&form=6&db=m Differential expression of peroxiredoxin 3 in laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 1.11.1.24 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29088845&form=6&db=m Nicotine suppresses apoptosis by regulating ?7nAChR/Prx1 axis in oral precancerous lesions. unassigned - 1.11.1.24 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31429766&form=6&db=m LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus. unassigned - 1.11.1.24 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33332365&form=6&db=m Peroxiredoxin 2 is highly expressed in human oral squamous cell carcinoma cells and is upregulated by human papillomavirus oncoproteins and arecoline, promoting proliferation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 1.11.1.24 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33969595&form=6&db=m Peroxiredoxin 5 is involved in cancer cell invasion and tumor growth of oral squamous cell carcinoma. causal interaction,ongoing research,unassigned 4,3,0 1.11.1.24 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34290530&form=6&db=m Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,3,0 1.11.1.24 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34512019&form=6&db=m Erratum: Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma [Corrigendum]. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0 1.11.1.24 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531683&form=6&db=m Erratum: Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma [Corrigendum]. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0 1.11.1.24 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19572210&form=6&db=m The response of Cupriavidus metallidurans CH34 to spaceflight in the international space station. therapeutic application,unassigned 1,0 1.11.1.24 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23761238&form=6&db=m A proteome analysis of the tetracyanonickelate (II) responses in Klebsiella oxytoca. unassigned - 1.11.1.24 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25398878&form=6&db=m Characterization of the Vibrio vulnificus 1-Cys peroxiredoxin Prx3 and regulation of its expression by the Fe-S cluster regulator IscR in response to oxidative stress and iron starvation. ongoing research,unassigned 2,0 1.11.1.24 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28357324&form=6&db=m Sulfur transfer and activation by ubiquitin-like modifier system Uba4•Urm1 link protein urmylation and tRNA thiolation in yeast. unassigned - 1.11.1.24 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31712251&form=6&db=m Biallelic VPS35L pathogenic variants cause 3C/Ritscher-Schinzel-like syndrome through dysfunction of retriever complex. causal interaction,therapeutic application,unassigned 1,3,0 1.11.1.24 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33518552&form=6&db=m The cytidine repressor regulates the survival of Pantoea agglomerans YS19 under oxidative stress and sulfur starvation conditions. ongoing research,therapeutic application,unassigned 2,1,0 1.11.1.24 Stillbirth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18544346&form=6&db=m Crucial role of peroxiredoxin III in placental antioxidant defense of mice. ongoing research,therapeutic application,unassigned 3,1,0 1.11.1.24 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12515392&form=6&db=m Synergistic effect of peroxiredoxin II antisense on cisplatin-induced cell death. ongoing research,therapeutic application,unassigned 3,1,0 1.11.1.24 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24750185&form=6&db=m Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 1.11.1.24 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27275098&form=6&db=m Serum Helicobacter pylori KatA and AhpC antibodies as novel biomarkers for gastric cancer. diagnostic usage,ongoing research,unassigned 3,1,0 1.11.1.24 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28423550&form=6&db=m Quantitative proteomic analysis of gastric cancer tissue reveals novel proteins in platelet-derived growth factor b signaling pathway. causal interaction,ongoing research,unassigned 2,2,0 1.11.1.24 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28535004&form=6&db=m Peroxiredoxin 5 overexpression enhances tumorigenicity and correlates with poor prognosis in gastric cancer. causal interaction,diagnostic usage,unassigned 3,2,0 1.11.1.24 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29422545&form=6&db=m Silencing of peroxiredoxin II by promoter methylation is necessary for the survival and migration of gastric cancer cells. diagnostic usage,unassigned 2,0 1.11.1.24 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29435053&form=6&db=m RKIP and peroxiredoxin 2 expression predicts the proliferative potential of gastric cancer stem cells. diagnostic usage,therapeutic application,unassigned 1,1,0 1.11.1.24 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29656298&form=6&db=m High Expression of Peroxiredoxin 1 Is Associated with Epithelial-Mesenchymal Transition Marker and Poor Prognosis in Gastric Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 1.11.1.24 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30214590&form=6&db=m Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.11.1.24 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30879771&form=6&db=m Inhibition of peroxiredoxin 2 suppresses Wnt/?-catenin signaling in gastric cancer. therapeutic application,unassigned 2,0 1.11.1.24 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31280208&form=6&db=m Peroxiredoxin V Inhibits Emodin-induced Gastric Cancer Cell Apoptosis via the ROS/Bcl2 Pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,1 1.11.1.24 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31536951&form=6&db=m PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.11.1.24 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31807984&form=6&db=m Prdx2 Upregulation Promotes the Growth and Survival of Gastric Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.11.1.24 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32148004&form=6&db=m [New early gastric cancer marker PRDX4 promote the tumorigenesis and progression of gastric cancer via eliminating ROS]. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 1.11.1.24 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32382548&form=6&db=m Systematic Characterization of Prognostic Values of Peroxiredoxin Family in Gastric Cancer. diagnostic usage,ongoing research,unassigned 4,3,0 1.11.1.24 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32929349&form=6&db=m Celastrol induces ROS-mediated apoptosis via directly targeting peroxiredoxin-2 in gastric cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 1.11.1.24 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33813388&form=6&db=m Peroxiredoxin V Silencing Elevates Susceptibility to Doxorubicin-induced Cell Apoptosis via ROS-dependent Mitochondrial Dysfunction in AGS Gastric Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.11.1.24 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34384442&form=6&db=m CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability. therapeutic application,unassigned 2,0 1.11.1.24 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21142207&form=6&db=m Brain Extracellular Fluid Protein Changes in Acute Stroke Patients. diagnostic usage,therapeutic application,unassigned 4,1,0 1.11.1.24 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22673994&form=6&db=m Peroxiredoxin sets the brain on fire after stroke. unassigned - 1.11.1.24 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24385276&form=6&db=m Peroxiredoxin 5 (PRX5) is correlated inversely to systemic markers of inflammation in acute stroke. causal interaction,ongoing research,unassigned 4,2,0 1.11.1.24 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27126918&form=6&db=m Different effects of arginine vasopressin on high-mobility group box 1 expression in astrocytes isolated from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats. unassigned - 1.11.1.24 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27924073&form=6&db=m Diagnostic performance of peroxiredoxin 1 to determine time-of-onset of acute cerebral infarction. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 1.11.1.24 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655626&form=6&db=m Effects of the Prdx2 depletion on blood pressure and life span in spontaneously hypertensive rats. ongoing research,therapeutic application,unassigned 3,1,0 1.11.1.24 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32002772&form=6&db=m Effects of Peroxiredoxin 2 in Neurological Disorders: A Review of its Molecular Mechanisms. ongoing research,therapeutic application,unassigned 4,3,0 1.11.1.24 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29554978&form=6&db=m Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,2,0 1.11.1.24 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30351993&form=6&db=m Peroxiredoxin 1/2 protects brain against H2O2-induced apoptosis after subarachnoid hemorrhage. therapeutic application,unassigned 3,0 1.11.1.24 Systemic Vasculitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20646000&form=6&db=m Peroxiredoxin 2 is a novel autoantigen for anti-endothelial cell antibodies in systemic vasculitis. unassigned - 1.11.1.24 Tachycardia, Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7785299&form=6&db=m [Experiences with the new cardioverter-defibrillator Ventak PRxII] diagnostic usage,ongoing research,unassigned 1,2,0 1.11.1.24 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18647502&form=6&db=m Identification of non-Alzheimer's disease tauopathies-related proteins by proteomic analysis. unassigned - 1.11.1.24 Teratoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24715692&form=6&db=m Dominant Role of Peroxiredoxin/JNK Axis in Stemness Regulation During Neurogenesis from Embryonic Stem Cells. causal interaction,unassigned 3,0 1.11.1.24 Thalassemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22960070&form=6&db=m Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 1.11.1.24 Thalassemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26058667&form=6&db=m The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in ?-Thalassemic Erythropoiesis. unassigned - 1.11.1.24 thioredoxin-dependent peroxiredoxin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15051715&form=6&db=m Peroxiredoxin-null yeast cells are hypersensitive to oxidative stress and are genomically unstable. unassigned - 1.11.1.24 thioredoxin-dependent peroxiredoxin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15902258&form=6&db=m Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. causal interaction,therapeutic application,unassigned 4,4,0 1.11.1.24 thioredoxin-dependent peroxiredoxin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21835911&form=6&db=m Peroxiredoxin 2 Deficiency Exacerbates Atherosclerosis in Apolipoprotein E-Deficient Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 1.11.1.24 thioredoxin-dependent peroxiredoxin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22099303&form=6&db=m Peroxiredoxin II is an essential antioxidant enzyme that prevents the oxidative inactivation of VEGF receptor-2 in vascular endothelial cells. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 thioredoxin-dependent peroxiredoxin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23101509&form=6&db=m Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress. causal interaction,unassigned 4,0 1.11.1.24 thioredoxin-dependent peroxiredoxin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23602274&form=6&db=m Peroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant that regulates NF-?B-mediated iNOS induction and microglial activation. causal interaction,therapeutic application,unassigned 4,2,0 1.11.1.24 thioredoxin-dependent peroxiredoxin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24048895&form=6&db=m Ablation of Peroxiredoxin II Attenuates Experimental Colitis by Increasing FoxO1-Induced Foxp3+ Regulatory T Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.11.1.24 thioredoxin-dependent peroxiredoxin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25802339&form=6&db=m Peroxiredoxin II is an antioxidant enzyme that negatively regulates collagen-stimulated platelet function. causal interaction,therapeutic application,unassigned 3,2,0 1.11.1.24 thioredoxin-dependent peroxiredoxin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29778464&form=6&db=m Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice. unassigned - 1.11.1.24 thioredoxin-dependent peroxiredoxin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29901182&form=6&db=m Peroxiredoxin I deficiency increases LPS?induced lethal shock in mice. ongoing research,unassigned 3,0 1.11.1.24 thioredoxin-dependent peroxiredoxin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30529270&form=6&db=m Peroxiredoxin 3 deficiency accelerates chronic kidney injury in mice through interactions between macrophages and tubular epithelial cells. causal interaction,ongoing research,unassigned 3,3,0 1.11.1.24 thioredoxin-dependent peroxiredoxin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31028193&form=6&db=m Protective Role of Peroxiredoxin I in Heat-Killed Staphylococcus Aureus-infected Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 1.11.1.24 thioredoxin-dependent peroxiredoxin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32141337&form=6&db=m Peroxiredoxin 2 deficiency does not affect insulin resistance and oxidative stress in high-fat diet-fed obese mice. therapeutic application,unassigned 1,0 1.11.1.24 thioredoxin-dependent peroxiredoxin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32205843&form=6&db=m Peroxiredoxin 5 deficiency exacerbates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus. unassigned - 1.11.1.24 thioredoxin-dependent peroxiredoxin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32639620&form=6&db=m Peroxiredoxin 2 deficiency reduces white adipogenesis due to the excessive ROS generation. causal interaction,unassigned 2,0 1.11.1.24 thioredoxin-dependent peroxiredoxin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32736685&form=6&db=m Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 1.11.1.24 thioredoxin-dependent peroxiredoxin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32929220&form=6&db=m Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17988525&form=6&db=m [Proteomic analysis on portal vein tumor thrombus-associated proteins for hepatocellular carcinoma] causal interaction,diagnostic usage,unassigned 1,3,0 1.11.1.24 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25802339&form=6&db=m Peroxiredoxin II is an antioxidant enzyme that negatively regulates collagen-stimulated platelet function. causal interaction,therapeutic application,unassigned 3,2,0 1.11.1.24 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33749526&form=6&db=m PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage. therapeutic application,unassigned 1,0 1.11.1.24 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20410161&form=6&db=m Suppression of MG132-mediated cell death by peroxiredoxin 1 through influence on ASK1 activation in human thyroid cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 1.11.1.24 Thyroiditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10530780&form=6&db=m Peroxiredoxin I expression in human thyroid tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.11.1.24 Tongue Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15955662&form=6&db=m Peroxiredoxin I expression in tongue squamous cell carcinomas as involved in tumor recurrence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.11.1.24 Toxoplasmosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28448521&form=6&db=m Immunization with Toxoplasma gondii peroxiredoxin 1 induces protective immunity against toxoplasmosis in mice. ongoing research,therapeutic application,unassigned 1,2,0 1.11.1.24 Toxoplasmosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32962648&form=6&db=m Evaluation of toxoplasmosis in pregnant women using dot-immunogold-silver staining with recombinant Toxoplasma gondii peroxiredoxin protein. ongoing research,therapeutic application,unassigned 1,2,0 1.11.1.24 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32316111&form=6&db=m Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells. ongoing research,therapeutic application,unassigned 1,2,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8596438&form=6&db=m Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: implications for sensitivity to isoniazid. causal interaction,unassigned 1,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8596439&form=6&db=m Green fluorescent protein as a marker for gene expression and cell biology of mycobacterial interactions with macrophages. ongoing research,therapeutic application,unassigned 3,1,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8655566&form=6&db=m Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis. therapeutic application,unassigned 1,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9119479&form=6&db=m Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9733688&form=6&db=m Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum. ongoing research,unassigned 1,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9866928&form=6&db=m [Multidrug-resistant tuberculosis. 2. Mechanisms of drug-resistance in Mycobacterium tuberculosis--genetic mechanisms of drug-resistance] unassigned - 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9883603&form=6&db=m [Mechanisms of drug-resistance in mycobacteria] unassigned - 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10639449&form=6&db=m Alkyl hydroperoxide reductases C and D are major antigens constitutively expressed by Mycobacterium avium subsp. paratuberculosis. diagnostic usage,ongoing research,unassigned 2,1,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11553532&form=6&db=m Silencing of oxidative stress response in Mycobacterium tuberculosis: expression patterns of ahpC in virulent and avirulent strains and effect of ahpC inactivation. causal interaction,unassigned 2,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12084012&form=6&db=m Site-directed mutagenesis reveals a novel catalytic mechanism of Mycobacterium tuberculosis alkylhydroperoxidase C. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14871480&form=6&db=m Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis. therapeutic application,unassigned 1,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15215090&form=6&db=m Inhibition of Mycobacterium tuberculosis AhpD, an element of the peroxiredoxin defense against oxidative stress. therapeutic application,unassigned 2,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15701515&form=6&db=m Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin. ongoing research,unassigned 1,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16682410&form=6&db=m The mycobacterial thioredoxin peroxidase can act as a one-cysteine peroxiredoxin. unassigned - 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16884737&form=6&db=m Functional and structural characterization of a thiol peroxidase from Mycobacterium tuberculosis. causal interaction,ongoing research,unassigned 1,4,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16923890&form=6&db=m Compensatory functions of two alkyl hydroperoxide reductases in the oxidative defense system of Legionella pneumophila. unassigned - 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19737009&form=6&db=m Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics. ongoing research,unassigned 1,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20060836&form=6&db=m An extracellular disulfide bond forming protein (DsbF) from Mycobacterium tuberculosis: structural, biochemical, and gene expression analysis. therapeutic application,unassigned 1,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21571062&form=6&db=m Oxidizing substrate specificity of Mycobacterium tuberculosis alkyl hydroperoxide reductase E: kinetics and mechanisms of oxidation and overoxidation. ongoing research,therapeutic application,unassigned 1,1,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27605010&form=6&db=m Peroxiredoxin 1 Contributes to Host Defenses against Mycobacterium tuberculosis. ongoing research,therapeutic application,unassigned 3,2,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27751911&form=6&db=m PrxQ B from Mycobacterium tuberculosis is a monomeric, thioredoxin-dependent and highly efficient fatty acid hydroperoxide reductase. diagnostic usage,ongoing research,unassigned 3,2,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28063347&form=6&db=m Disruption of redox catalytic functions of peroxiredoxin-thioredoxin complex in Mycobacterium tuberculosis H37Rv using small interface binding molecules. unassigned - 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29325117&form=6&db=m Prospective Discrimination of Controllers From Progressors Early After Low-Dose Mycobacterium tuberculosis Infection of Cynomolgus Macaques using Blood RNA Signatures. therapeutic application,unassigned 2,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30405878&form=6&db=m Role of Oxidative Stress in the Pathology and Management of Human Tuberculosis. causal interaction,diagnostic usage,unassigned 2,1,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31311857&form=6&db=m Kinetics of formation and reactivity of the persulfide in the one-cysteine peroxiredoxin from Mycobacterium tuberculosis. ongoing research,unassigned 3,0 1.11.1.24 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31718175&form=6&db=m Multiscale Modeling of Thiol Overoxidation in Peroxiredoxins by Hydrogen Peroxide. ongoing research,unassigned 2,0 1.11.1.24 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28684424&form=6&db=m IL-4 up-regulates cyclooxygenase-1 expression in macrophages. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 Tularemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30870480&form=6&db=m Role of peroxiredoxin of the AhpC/TSA family in antioxidant defense mechanisms of Francisella tularensis. unassigned - 1.11.1.24 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16516038&form=6&db=m Enhanced Expression of Peroxiredoxin I and VI Correlates with Development, Recurrence and Progression of Human Bladder Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 1.11.1.24 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24083701&form=6&db=m Screening of Differentially Expressed Genes Related to Bladder Cancer and Functional Analysis with DNA Microarray. causal interaction,unassigned 4,0 1.11.1.24 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19424615&form=6&db=m Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.11.1.24 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20718351&form=6&db=m [Expression of peroxiredoxin III cervical lesions] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 1.11.1.24 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23599374&form=6&db=m Proteomic Identification of Neoadjuvant Chemotherapy-Related Proteins in Bulky Stage IB-IIA Squamous Cervical Cancer. causal interaction,diagnostic usage,unassigned 3,2,0 1.11.1.24 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23772374&form=6&db=m Anti-apoptotic role of peroxiredoxin III in cervical cancer cells. ongoing research,unassigned 3,0 1.11.1.24 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24648924&form=6&db=m Peroxiredoxin 3 is a novel marker for cell proliferation in cervical cancer. diagnostic usage,ongoing research,unassigned 1,3,0 1.11.1.24 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27601940&form=6&db=m Differential proteins among normal cervix cells and cervical cancer cells with HPV-16 infection, through mass spectrometry-based Proteomics (2D-DIGE) in women from Southern México. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0 1.11.1.24 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31470801&form=6&db=m Expression of thioredoxin 1 and peroxiredoxins in squamous cervical carcinoma and its predictive role in NACT. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 1.11.1.24 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31956363&form=6&db=m Up-regulation of peroxiredoxin-1 promotes cell proliferation and metastasis and inhibits apoptosis in cervical cancer. diagnostic usage,ongoing research,unassigned 3,4,0 1.11.1.24 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16081824&form=6&db=m IL-10 from regulatory T cells determines vaccine efficacy in murine Leishmania major infection. ongoing research,unassigned 2,0 1.11.1.24 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17101647&form=6&db=m Heterologous priming-boosting with DNA and modified vaccinia virus Ankara expressing tryparedoxin peroxidase promotes long-term memory against Leishmania major in susceptible BALB/c Mice. ongoing research,unassigned 2,0 1.11.1.24 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19095029&form=6&db=m A prime/boost DNA/Modified vaccinia virus Ankara vaccine expressing recombinant Leishmania DNA encoding TRYP is safe and immunogenic in outbred dogs, the reservoir of zoonotic visceral leishmaniasis. ongoing research,therapeutic application,unassigned 2,2,0 1.11.1.24 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19386420&form=6&db=m Selection of appropriate serological tests to measure the incidence of natural Leishmania infantum infection during DNA/MVA prime/boost canine vaccine trials. unassigned - 1.11.1.24 Varicocele http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31006709&form=6&db=m Proteomic analysis of seminal plasma from bilateral varicocele patients indicates an oxidative state and increased inflammatory response. causal interaction,diagnostic usage,unassigned 1,4,0 1.11.1.24 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32929220&form=6&db=m Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm. causal interaction,therapeutic application,unassigned 4,1,0 1.11.1.24 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23820076&form=6&db=m Vascular Injury Involves the Overoxidation of Peroxiredoxin Type II and Is Recovered by the Peroxiredoxin Activity Mimetic That Induces Reendothelialization. therapeutic application,unassigned 1,0 1.11.1.24 Vasculitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15665454&form=6&db=m Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 1.11.1.24 Vasculitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17298582&form=6&db=m Vasculitis induced by immunization with Bacillus Calmette-Guérin followed by atypical mycobacterium antigen: a new mouse model for Kawasaki disease. causal interaction,therapeutic application,unassigned 2,4,0 1.11.1.24 Vasculitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22003971&form=6&db=m A novel anti-peroxiredoxin autoantibody in patients with Kawasaki disease. causal interaction,diagnostic usage,unassigned 1,3,0 1.11.1.24 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15607657&form=6&db=m Characterization of a silkworm thioredoxin peroxidase that is induced by external temperature stimulus and viral infection. unassigned - 1.11.1.24 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21715486&form=6&db=m The Human Cytomegalovirus Protein pUL38 Suppresses Endoplasmic Reticulum Stress-Mediated Cell Death Independently of Its Ability To Induce mTORC1 Activation. unassigned - 1.11.1.24 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24418456&form=6&db=m Molecular characterization, immune response against white spot syndrome virus infection of peroxiredoxin 4 in Fenneropenaeus chinensis and its antioxidant activity. diagnostic usage,ongoing research,unassigned 1,2,0 1.11.1.24 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31708904&form=6&db=m Quantitative Proteomics Reveal Peroxiredoxin Perturbation Upon Persistent Lymphocytic Choriomeningitis Virus Infection in Human Cells. causal interaction,ongoing research,unassigned 2,2,0