1.1.3.8 Ascorbic Acid Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4067654&form=6&db=m Requirement for ascorbic acid in a rat mutant unable to synthesize ascorbic acid. causal interaction,unassigned 1,0 1.1.3.8 Ascorbic Acid Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10467707&form=6&db=m The L-gulono-gamma-lactone oxidase gene (GULO) which is a candidate for vitamin C deficiency in pigs maps to chromosome 14. causal interaction,unassigned 1,0 1.1.3.8 Ascorbic Acid Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15112110&form=6&db=m Intragenic deletion in the gene encoding L-gulonolactone oxidase causes vitamin C deficiency in pigs. unassigned - 1.1.3.8 Ascorbic Acid Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16059632&form=6&db=m Spontaneous fractures in the mouse mutant sfx are caused by deletion of the gulonolactone oxidase gene, causing vitamin C deficiency. unassigned - 1.1.3.8 Ascorbic Acid Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16988135&form=6&db=m Vitamin C deficiency increases the lung pathology of influenza virus-infected gulo-/- mice. causal interaction,ongoing research,unassigned 1,4,0 1.1.3.8 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28548062&form=6&db=m Gulonolactone Addition to Human Hepatocellular Carcinoma Cells with Gene Transfer of Gulonolactone Oxidase Restores Ascorbate Biosynthesis and Reduces Hypoxia Inducible Factor 1. ongoing research,therapeutic application,unassigned 4,1,0 1.1.3.8 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29625084&form=6&db=m Vitamin C deficiency aggravates tumor necrosis factor ?-induced insulin resistance. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 1.1.3.8 Chronic Limb-Threatening Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31663308&form=6&db=m Clinical and anatomical variables associated in the literature to limb graft occlusion after endovascular aneurysm repair compared to the experience of a tertiary referral center. unassigned - 1.1.3.8 Deficiency Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3741630&form=6&db=m Intravascularly administered crosslinked immunoprecipitates of gulonolactone oxidase are toxic and rapidly cleared from the circulation. causal interaction,therapeutic application,unassigned 4,1,0 1.1.3.8 Fractures, Spontaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16059632&form=6&db=m Spontaneous fractures in the mouse mutant sfx are caused by deletion of the gulonolactone oxidase gene, causing vitamin C deficiency. unassigned - 1.1.3.8 Fractures, Spontaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17510056&form=6&db=m Nuclear factor-E2-related factor-1 mediates ascorbic acid induction of osterix expression via interaction with antioxidant-responsive element in bone cells. causal interaction,unassigned 4,0 1.1.3.8 Fractures, Spontaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25133246&form=6&db=m Genome wide analysis of sex difference in gene expression profiles of bone formations using sfx mice and BXD RI strains. ongoing research,unassigned 2,0 1.1.3.8 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16632110&form=6&db=m Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 1.1.3.8 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16988135&form=6&db=m Vitamin C deficiency increases the lung pathology of influenza virus-infected gulo-/- mice. causal interaction,ongoing research,unassigned 1,4,0 1.1.3.8 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20541428&form=6&db=m In situ SEM, TEM and AFM studies of the antimicrobial activity of lemon grass oil in liquid and vapour phase against Candida albicans. therapeutic application,unassigned 3,0 1.1.3.8 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16988135&form=6&db=m Vitamin C deficiency increases the lung pathology of influenza virus-infected gulo-/- mice. causal interaction,ongoing research,unassigned 1,4,0 1.1.3.8 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29625084&form=6&db=m Vitamin C deficiency aggravates tumor necrosis factor ?-induced insulin resistance. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 1.1.3.8 l-gulonolactone oxidase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1400508&form=6&db=m A missense mutation of L-gulono-gamma-lactone oxidase causes the inability of scurvy-prone osteogenic disorder rats to synthesize L-ascorbic acid. causal interaction,unassigned 4,0 1.1.3.8 l-gulonolactone oxidase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2563976&form=6&db=m Expression of the mutant gene for L-gulono-gamma-lactone oxidase in scurvy-prone rats. causal interaction,unassigned 4,0 1.1.3.8 l-gulonolactone oxidase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3134028&form=6&db=m L-gulono-gamma-lactone oxidase deficiency in rats with osteogenic disorder: enzymological and immunochemical studies. causal interaction,unassigned 4,0 1.1.3.8 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21878346&form=6&db=m Effects of ascorbic acid on carcinogenicity and acute toxicity of nickel subsulfide, and on tumor transplants growth in gulonolactone oxidase knock-out mice and wild-type C57BL mice. ongoing research,unassigned 4,0 1.1.3.8 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31306418&form=6&db=m Computational design of improved standardized chemotherapy protocols for grade II oligodendrogliomas. ongoing research,therapeutic application,unassigned 2,1,0 1.1.3.8 Pancreatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17627094&form=6&db=m 'Do research with seriousness and perseverance'. An interview with Prof. Lucio Gullo. Interview by Martin E. Fernandez-Zapico. causal interaction,unassigned 1,0 1.1.3.8 Parasitemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20484858&form=6&db=m Vitamin C deficiency fails to protect mice from malaria. ongoing research,therapeutic application,unassigned 4,1,0 1.1.3.8 Riboflavin Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7397229&form=6&db=m L-gulonolactone oxidase activity and vitamin C status in riboflavin-deficient rats. ongoing research,unassigned 4,0 1.1.3.8 Scurvy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=819930&form=6&db=m Immunologic evidence that the gene for L-gulono-gamma-lactone oxidase is not expressed in animals subject to scurvy. unassigned - 1.1.3.8 Scurvy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1400508&form=6&db=m A missense mutation of L-gulono-gamma-lactone oxidase causes the inability of scurvy-prone osteogenic disorder rats to synthesize L-ascorbic acid. causal interaction,unassigned 4,0 1.1.3.8 Scurvy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3741630&form=6&db=m Intravascularly administered crosslinked immunoprecipitates of gulonolactone oxidase are toxic and rapidly cleared from the circulation. causal interaction,therapeutic application,unassigned 4,1,0 1.1.3.8 Scurvy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7104431&form=6&db=m Feasibility of using an isolated intestinal segment as an artificial organ for enzyme replacement therapy. unassigned - 1.1.3.8 Scurvy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9707638&form=6&db=m Body pool and synthesis of ascorbic acid in adult sea lamprey (Petromyzon marinus): An agnathan fish with gulonolactone oxidase activity therapeutic application,unassigned 1,0 1.1.3.8 Scurvy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21931508&form=6&db=m Differential gene expression between wild-type and Gulo-deficient mice supplied with vitamin C. ongoing research,unassigned 2,0 1.1.3.8 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24986208&form=6&db=m Genetic features of oligodendrogliomas and presence of seizures. The relationship of seizures and genetics in LGOs. diagnostic usage,ongoing research,unassigned 1,3,0 1.1.3.8 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16956367&form=6&db=m Mycobacterium tuberculosis possesses a functional enzyme for the synthesis of vitamin C, L-gulono-1,4-lactone dehydrogenase. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 1.1.3.8 Vitamin E Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14409489&form=6&db=m Formation of malonaldehyde in vitamin E deficiency and its relation to the inhibition of gulonolactone oxidase. causal interaction,therapeutic application,unassigned 4,1,0