1.1.1.145 3(or 17)beta-hydroxysteroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10599696&form=6&db=m New insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency: identification of eight mutations in the HSD3B2 gene eleven patients from seven new families and comparison of the functional properties of twenty-five mutant enzymes. causal interaction,ongoing research,unassigned 4,2,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1295433&form=6&db=m [Partial 3-beta-hydroxysteroid dehydrogenase deficiencies] causal interaction,diagnostic usage,unassigned 4,1,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1340685&form=6&db=m [Adrenal enzymatic block with late-onset caused by 11-hydroxylase deficiency. Apropos of 29 cases] causal interaction,unassigned 3,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1668983&form=6&db=m [Polycystic ovary syndrome as expression of 3-beta-hydroxysteroid dehydrogenase deficiency] causal interaction,diagnostic usage,unassigned 4,1,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2522036&form=6&db=m [Clinical features and diagnosis of mild 3-beta-hydroxysteroid dehydrogenase deficiency in men] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3160950&form=6&db=m Elevated 17-hydroxyprogesterone and testosterone in a newborn with 3-beta-hydroxysteroid dehydrogenase deficiency. causal interaction,therapeutic application,unassigned 4,1,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5846696&form=6&db=m Adrenogenital syndrome. Association with 3-beta-hydroxysteroid dehydrogenase deficiency. causal interaction,unassigned 4,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6968003&form=6&db=m Urinary steroidal pattern of infants with congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase deficiency. causal interaction,unassigned 4,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7590644&form=6&db=m Serum and urinary steroids in girls with precocious pubarche and/or hirsutism due to mild 3-beta-hydroxysteroid dehydrogenase deficiency. causal interaction,unassigned 4,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7984541&form=6&db=m [Late onset hyperandrogenism caused by 3-beta-hydroxysteroid dehydrogenase deficiency] causal interaction,unassigned 4,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9120982&form=6&db=m Testis sparing surgery for steroid unresponsive testicular tumors of the adrenogenital syndrome. causal interaction,unassigned 4,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11192529&form=6&db=m 3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase deficiency in a 23-year-old woman. causal interaction,unassigned 4,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12608938&form=6&db=m Carriers for type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) deficiency can only be identified by HSD3B2 genotype study and not by hormone test. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14260992&form=6&db=m CONCURRENT 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY IN ADRENAL AND SCLEROCYSTIC OVARY. causal interaction,unassigned 3,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14764797&form=6&db=m The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585552&form=6&db=m Refining hormonal diagnosis of type II 3beta-hydroxysteroid dehydrogenase deficiency in patients with premature pubarche and hirsutism based on HSD3B2 genotyping. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17496421&form=6&db=m A case of 3beta-hydroxysteroid dehydrogenase type II (HSD3B2) deficiency picked up by neonatal screening for 21-hydroxylase deficiency: difficulties and delay in etiologic diagnosis. causal interaction,diagnostic usage,unassigned 4,4,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18252794&form=6&db=m Carboxyl-Terminal Mutations in 3{beta}-Hydroxysteroid Dehydrogenase Type II Cause Severe Salt-Wasting Congenital Adrenal Hyperplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20400917&form=6&db=m Titration of Bile Acid Supplements in 3beta-Hydroxy-Delta5-C27-Steroid Dehydrogenase/Isomerase Deficiency. causal interaction,unassigned 4,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20531254&form=6&db=m Molecular genetic and bile acid profiles in two Japanese patients with 3beta-hydroxy-DELTA5-C27-steroid dehydrogenase/isomerase deficiency. causal interaction,diagnostic usage,unassigned 4,3,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24793988&form=6&db=m Steroidogenesis of the testis -- new genes and pathways. causal interaction,unassigned 4,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25974401&form=6&db=m Two Zebrafish hsd3b Genes Are Distinct in Function, Expression, and Evolution. causal interaction,unassigned 3,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26079780&form=6&db=m Severe Salt-Losing 3?-Hydroxysteroid Dehydrogenase Deficiency: Treatment and Outcomes of HSD3B2 c.35G>A Homozygotes. causal interaction,unassigned 4,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26290012&form=6&db=m Human 3?-hydroxysteroid dehydrogenase deficiency seems to affect fertility but may not harbor a tumor risk: lesson from an experiment of nature. causal interaction,unassigned 3,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30811025&form=6&db=m Comprehensive genotyping of Turkish women with hirsutism. causal interaction,unassigned 2,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32506065&form=6&db=m Co-Existence of Congenital Adrenal Hyperplasia and Bartter Syndrome due to Maternal Uniparental Isodisomy of HSD3B2 and CLCNKB Mutations. causal interaction,diagnostic usage,unassigned 4,1,0 1.1.1.145 3beta-hydroxy-delta5-steroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34055358&form=6&db=m Case of an unreported genetic variant of salt losing 3-?-hydroxysteroid dehydrogenase deficiency. causal interaction,unassigned 3,0 1.1.1.145 3beta-hydroxysteroid 3-dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10599696&form=6&db=m New insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency: identification of eight mutations in the HSD3B2 gene eleven patients from seven new families and comparison of the functional properties of twenty-five mutant enzymes. causal interaction,ongoing research,unassigned 4,2,0 1.1.1.145 3beta-hydroxysteroid 3-dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10651755&form=6&db=m Mutations in the type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) gene can cause premature pubarche in girls. causal interaction,therapeutic application,unassigned 4,1,0 1.1.1.145 3beta-hydroxysteroid 3-dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10843183&form=6&db=m A novel A10E homozygous mutation in the HSD3B2 gene causing severe salt-wasting 3beta-hydroxysteroid dehydrogenase deficiency in 46,XX and 46,XY French-Canadians: evaluation of gonadal function after puberty. causal interaction,unassigned 4,0 1.1.1.145 3beta-hydroxysteroid 3-dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585552&form=6&db=m Refining hormonal diagnosis of type II 3beta-hydroxysteroid dehydrogenase deficiency in patients with premature pubarche and hirsutism based on HSD3B2 genotyping. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=161161&form=6&db=m [Congenital adrenal hyperplasia due to blockade of 3-beta-hydroxysteroid dehydrogenase] causal interaction,unassigned 3,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4315485&form=6&db=m Unusual type of congenital adrenal hyperplasia probably due to deficiency of 3-beta-hydroxysteroid dehydrogenase. Case report of a surviving girl and steroid studies. causal interaction,unassigned 4,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6968003&form=6&db=m Urinary steroidal pattern of infants with congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase deficiency. causal interaction,unassigned 4,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10599696&form=6&db=m New insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency: identification of eight mutations in the HSD3B2 gene eleven patients from seven new families and comparison of the functional properties of twenty-five mutant enzymes. causal interaction,ongoing research,unassigned 4,2,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10843183&form=6&db=m A novel A10E homozygous mutation in the HSD3B2 gene causing severe salt-wasting 3beta-hydroxysteroid dehydrogenase deficiency in 46,XX and 46,XY French-Canadians: evaluation of gonadal function after puberty. causal interaction,unassigned 4,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11196452&form=6&db=m A new insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency. causal interaction,unassigned 4,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12428206&form=6&db=m Congenital adrenal hyperplasia due to 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase deficiency. causal interaction,unassigned 4,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12608938&form=6&db=m Carriers for type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) deficiency can only be identified by HSD3B2 genotype study and not by hormone test. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585552&form=6&db=m Refining hormonal diagnosis of type II 3beta-hydroxysteroid dehydrogenase deficiency in patients with premature pubarche and hirsutism based on HSD3B2 genotyping. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17496421&form=6&db=m A case of 3beta-hydroxysteroid dehydrogenase type II (HSD3B2) deficiency picked up by neonatal screening for 21-hydroxylase deficiency: difficulties and delay in etiologic diagnosis. causal interaction,diagnostic usage,unassigned 4,4,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18252794&form=6&db=m Carboxyl-Terminal Mutations in 3{beta}-Hydroxysteroid Dehydrogenase Type II Cause Severe Salt-Wasting Congenital Adrenal Hyperplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21340167&form=6&db=m Structural aspects of the p.P222Q homozygous mutation of HSD3B2 gene in a patient with congenital adrenal hyperplasia. causal interaction,ongoing research,unassigned 4,2,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22343390&form=6&db=m A Novel Homozygous Q334X Mutation in the HSD3B2 Gene Causing Classic 3?-Hydroxysteroid Dehydrogenase Deficiency: An Unexpected Diagnosis after a Positive Newborn Screen for 21-Hydroxylase Deficiency. causal interaction,unassigned 4,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25322271&form=6&db=m A novel missense mutation in the HSD3B2 gene, underlying nonsalt-wasting congenital adrenal hyperplasia. new insight into the structure-function relationships of 3?-hydroxysteroid dehidrogenase type II. causal interaction,unassigned 4,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25619355&form=6&db=m [A novel homozygous mutation p.E25X in the HSD3B2 gene causing salt wasting 3?-hydroxysteroid dehydrogenases deficiency in a Chinese pubertal girl: a delayed diagnosis until recurrent ovary cysts]. causal interaction,unassigned 3,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25974401&form=6&db=m Two Zebrafish hsd3b Genes Are Distinct in Function, Expression, and Evolution. causal interaction,unassigned 3,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26079780&form=6&db=m Severe Salt-Losing 3?-Hydroxysteroid Dehydrogenase Deficiency: Treatment and Outcomes of HSD3B2 c.35G>A Homozygotes. causal interaction,unassigned 4,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27082427&form=6&db=m A New Homozygous Frameshift Mutation in the HSD3B2 Gene in an Apparently Nonconsanguineous Italian Family. causal interaction,ongoing research,unassigned 4,1,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27626911&form=6&db=m Non-Virilizing Congenital Adrenal Hyperplasia in a Female Patient with a Novel HSD3B2 Mutation. causal interaction,unassigned 3,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32072793&form=6&db=m Birth of a healthy boy following preimplantation genetic diagnosis for congenital adrenal hyperplasia. causal interaction,unassigned 4,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32506065&form=6&db=m Co-Existence of Congenital Adrenal Hyperplasia and Bartter Syndrome due to Maternal Uniparental Isodisomy of HSD3B2 and CLCNKB Mutations. causal interaction,diagnostic usage,unassigned 4,1,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33180036&form=6&db=m Late diagnosis of 3?-Hydroxysteroid dehydrogenase deficiency: the pivotal role of gas chromatography-mass spectrometry urinary steroid metabolome analysis and a novel homozygous nonsense mutation in the HSD3B2 gene. causal interaction,unassigned 4,0 1.1.1.145 Adrenal Hyperplasia, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33757164&form=6&db=m Three cases of 3?-hydroxysteroid dehydrogenase deficiency: Clinical analysis. causal interaction,unassigned 4,0 1.1.1.145 Adrenocortical Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11139773&form=6&db=m Differential regulation of 3beta-hydroxysteroid dehydrogenase type II and 17alpha-hydroxylase/lyase P450 in human adrenocortical carcinoma cells by epidermal growth factor and basic fibroblast growth factor. diagnostic usage,ongoing research,unassigned 3,4,0 1.1.1.145 Adrenocortical Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22654799&form=6&db=m Sunitinib Inhibits Cell Proliferation and Alters Steroidogenesis by Down-Regulation of HSD3B2 in Adrenocortical Carcinoma Cells. ongoing research,unassigned 3,0 1.1.1.145 Adrenogenital Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5846696&form=6&db=m Adrenogenital syndrome. Association with 3-beta-hydroxysteroid dehydrogenase deficiency. causal interaction,unassigned 4,0 1.1.1.145 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32506065&form=6&db=m Co-Existence of Congenital Adrenal Hyperplasia and Bartter Syndrome due to Maternal Uniparental Isodisomy of HSD3B2 and CLCNKB Mutations. causal interaction,diagnostic usage,unassigned 4,1,0 1.1.1.145 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18955108&form=6&db=m Structural basis for the selective inhibition of human 3beta-hydroxysteroid dehydrogenase 1 in human breast tumor MCF-7 cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 1.1.1.145 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31060224&form=6&db=m Genomic Profiling of the Steroidogenic Acute Regulatory Protein in Breast Cancer: In Silico Assessments and a Mechanistic Perspective. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 1.1.1.145 Cryptorchidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30328339&form=6&db=m A rare variety of congenital adrenal hyperplasia with mosaic Klinefelter syndrome: a unique combination presenting with ambiguous genitalia and sexual precocity causal interaction,unassigned 3,0 1.1.1.145 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25078683&form=6&db=m The steroid hormone environment during primordial follicle formation in perinatal mouse ovaries. unassigned - 1.1.1.145 Disorders of Sex Development http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585552&form=6&db=m Refining hormonal diagnosis of type II 3beta-hydroxysteroid dehydrogenase deficiency in patients with premature pubarche and hirsutism based on HSD3B2 genotyping. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.1.1.145 Disorders of Sex Development http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21340167&form=6&db=m Structural aspects of the p.P222Q homozygous mutation of HSD3B2 gene in a patient with congenital adrenal hyperplasia. causal interaction,ongoing research,unassigned 4,2,0 1.1.1.145 Disorders of Sex Development http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27082427&form=6&db=m A New Homozygous Frameshift Mutation in the HSD3B2 Gene in an Apparently Nonconsanguineous Italian Family. causal interaction,ongoing research,unassigned 4,1,0 1.1.1.145 Disorders of Sex Development http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30328339&form=6&db=m A rare variety of congenital adrenal hyperplasia with mosaic Klinefelter syndrome: a unique combination presenting with ambiguous genitalia and sexual precocity causal interaction,unassigned 3,0 1.1.1.145 Disorders of Sex Development http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33180036&form=6&db=m Late diagnosis of 3?-Hydroxysteroid dehydrogenase deficiency: the pivotal role of gas chromatography-mass spectrometry urinary steroid metabolome analysis and a novel homozygous nonsense mutation in the HSD3B2 gene. causal interaction,unassigned 4,0 1.1.1.145 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19022561&form=6&db=m The nuclear receptors SF1 and LRH1 are expressed in endometrial cancer cells and regulate steroidogenic gene transcription by cooperating with AP-1 factors. causal interaction,unassigned 1,0 1.1.1.145 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25137424&form=6&db=m Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 1.1.1.145 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29664547&form=6&db=m HSD3B2, HSD17B1, HSD17B2, ESR1, ESR2 and AR expression in infertile women with endometriosis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 1.1.1.145 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20660004&form=6&db=m Association of HSD3B1 and HSD3B2 gene polymorphisms with essential hypertension, aldosterone level, and left ventricular structure. causal interaction,ongoing research,unassigned 3,4,0 1.1.1.145 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22371315&form=6&db=m Aetiology of hypospadias: a systematic review of genes and environment. causal interaction,diagnostic usage,unassigned 1,1,0 1.1.1.145 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014873&form=6&db=m miR-29a-5p Regulates the Proliferation, Invasion, and Migration of Gliomas by Targeting DHRS4. causal interaction,therapeutic application,unassigned 4,4,0 1.1.1.145 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17456400&form=6&db=m [Effects of infrasound on activities of 3beta hydroxysteroid dehydrogenase and acid phosphatase of polygonal cells in adrenal cortex zona fasciculate in mice] diagnostic usage,ongoing research,unassigned 3,3,0 1.1.1.145 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18000308&form=6&db=m Human adrenal corticocarcinoma NCI-H295R cells produce more androgens than NCI-H295A cells and differ in 3beta-hydroxysteroid dehydrogenase type 2 and 17,20 lyase activities. unassigned - 1.1.1.145 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21185375&form=6&db=m Human adrenal cells that express both 3?-hydroxysteroid dehydrogenase type 2 (HSD3B2) and cytochrome b5 (CYB5A) contribute to adrenal androstenedione production. unassigned - 1.1.1.145 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21422683&form=6&db=m A case of primary aldosteronism caused by multiple adrenocortical macronodules. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 1.1.1.145 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22975484&form=6&db=m Circadian clock-deficient mice as a tool for exploring disease etiology. causal interaction,unassigned 4,0 1.1.1.145 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24075909&form=6&db=m Immunolocalization of murine type VI 3?-hydroxysteroid dehydrogenase in the adrenal gland, testis, skin, and placenta. causal interaction,unassigned 1,0 1.1.1.145 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27670690&form=6&db=m DNA methylation is not involved in specific down-regulation of HSD3B2, NR4A1 and RARB genes in androgen-secreting cells of human adrenal cortex. diagnostic usage,ongoing research,unassigned 1,2,0 1.1.1.145 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28863887&form=6&db=m Development of monoclonal antibodies against the human 3?-hydroxysteroid dehydrogenase/isomerase isozymes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 1.1.1.145 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30753518&form=6&db=m 11-Oxygenated C19 Steroids Do Not Decline with Age in Women. unassigned - 1.1.1.145 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33024080&form=6&db=m Alteration of the steroidogenesis in boys with autism spectrum disorders. causal interaction,unassigned 3,0 1.1.1.145 Hirsutism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7590644&form=6&db=m Serum and urinary steroids in girls with precocious pubarche and/or hirsutism due to mild 3-beta-hydroxysteroid dehydrogenase deficiency. causal interaction,unassigned 4,0 1.1.1.145 Hirsutism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10973654&form=6&db=m Genotyping of the type II 3beta-hydroxysteroid dehydrogenase gene (HSD3B2) in women with hirsutism and elevated ACTH-stimulated delta(5)-steroids. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 1.1.1.145 Hirsutism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585552&form=6&db=m Refining hormonal diagnosis of type II 3beta-hydroxysteroid dehydrogenase deficiency in patients with premature pubarche and hirsutism based on HSD3B2 genotyping. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.1.1.145 Hirsutism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30811025&form=6&db=m Comprehensive genotyping of Turkish women with hirsutism. causal interaction,unassigned 2,0 1.1.1.145 Hyperaldosteronism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28863887&form=6&db=m Development of monoclonal antibodies against the human 3?-hydroxysteroid dehydrogenase/isomerase isozymes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 1.1.1.145 Hyperandrogenism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7984541&form=6&db=m [Late onset hyperandrogenism caused by 3-beta-hydroxysteroid dehydrogenase deficiency] causal interaction,unassigned 4,0 1.1.1.145 Hyperandrogenism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9719627&form=6&db=m Variants of the type II 3beta-hydroxysteroid dehydrogenase gene in children with premature pubic hair and hyperandrogenic adolescents. causal interaction,unassigned 3,0 1.1.1.145 Hyperandrogenism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18683055&form=6&db=m Nonhuman primates as models for human adrenal androgen production: Function and dysfunction. causal interaction,unassigned 3,0 1.1.1.145 Hyperandrogenism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30650063&form=6&db=m Baicalin inhibits recruitment of GATA1 to the HSD3B2 promoter and reverses hyperandrogenism of PCOS. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 1.1.1.145 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20023637&form=6&db=m Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 1.1.1.145 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20660004&form=6&db=m Association of HSD3B1 and HSD3B2 gene polymorphisms with essential hypertension, aldosterone level, and left ventricular structure. causal interaction,ongoing research,unassigned 3,4,0 1.1.1.145 Hypogonadism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6044949&form=6&db=m [3-Beta-hydroxysteroid dehydrogenase activity in hypogonadotropic hypogonadism] unassigned - 1.1.1.145 Hypogonadism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30328339&form=6&db=m A rare variety of congenital adrenal hyperplasia with mosaic Klinefelter syndrome: a unique combination presenting with ambiguous genitalia and sexual precocity causal interaction,unassigned 3,0 1.1.1.145 Hypospadias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5949129&form=6&db=m Production of congenital adrenal cortical hyperplasia, hypospadias, and clitoral hypertrophy (adrenogenital syndrome) in rats by inactivation of 3-beta-hydroxysteroid dehydrogenase. unassigned - 1.1.1.145 Hypospadias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14764821&form=6&db=m Molecular study of the 3 beta-hydroxysteroid dehydrogenase gene type II in patients with hypospadias. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 1.1.1.145 Hypospadias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22371315&form=6&db=m Aetiology of hypospadias: a systematic review of genes and environment. causal interaction,diagnostic usage,unassigned 1,1,0 1.1.1.145 Hypospadias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27079746&form=6&db=m Maternal exposure to di-n-butyl phthalate (DBP) induces combined anorectal and urogenital malformations in male rat offspring. causal interaction,diagnostic usage,unassigned 3,1,0 1.1.1.145 Hypospadias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33180036&form=6&db=m Late diagnosis of 3?-Hydroxysteroid dehydrogenase deficiency: the pivotal role of gas chromatography-mass spectrometry urinary steroid metabolome analysis and a novel homozygous nonsense mutation in the HSD3B2 gene. causal interaction,unassigned 4,0 1.1.1.145 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26537554&form=6&db=m Term neonates with infection and shock display high cortisol precursors despite low levels of normal cortisol. causal interaction,unassigned 2,0 1.1.1.145 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15208301&form=6&db=m The orphan nuclear receptor NGFIB regulates transcription of 3beta-hydroxysteroid dehydrogenase. implications for the control of adrenal functional zonation. ongoing research,unassigned 2,0 1.1.1.145 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21669218&form=6&db=m Testosterone response of hepatic gene expression in female mice having acquired testosterone-unresponsive immunity to Plasmodium chabaudi malaria. diagnostic usage,unassigned 1,0 1.1.1.145 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14764797&form=6&db=m The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 1.1.1.145 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31006191&form=6&db=m [Effects of metformin on the expression of estrogen synthetase and ER mRNA in uterine leiomyoma tissues]. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 1.1.1.145 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29803408&form=6&db=m Up regulation of the steroid hormone synthesis regulator HSD3B2 is linked to early PSA recurrence in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.1.1.145 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22356824&form=6&db=m Polymorphisms in AKR1C4 and HSD3B2 and differences in serum DHEAS and progesterone are associated with paranoid ideation during mania or hypomania in bipolar disorder. causal interaction,unassigned 3,0 1.1.1.145 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29803408&form=6&db=m Up regulation of the steroid hormone synthesis regulator HSD3B2 is linked to early PSA recurrence in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.1.1.145 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1448884&form=6&db=m Ultrastructure and immunohistochemistry of a fetal-type Leydig cell tumor. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 1.1.1.145 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3095581&form=6&db=m Gonadotropin, steroid, and thyroid hormone milieu of young SWR mice bearing spontaneous granulosa cell tumors. diagnostic usage,ongoing research,unassigned 4,4,0 1.1.1.145 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5890905&form=6&db=m [Deficiency of 3-beta-hydroxysteroid dehydrogenase in endocrine-active tumor of the ovary] causal interaction,unassigned 4,0 1.1.1.145 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14130301&form=6&db=m THE HISTOCHEMISTRY OF 3-BETA-HYDROXYSTEROID DEHYDROGENASE. I. WITH SPECIAL REFERENCE TO ADRENAL GLANDS, AS AFFECTED BY ACTH, COLD, TRAUMA, AND TUMOR. therapeutic application,unassigned 1,0 1.1.1.145 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15666848&form=6&db=m The higher affinity of human type 1 3beta-hydroxysteroid dehydrogenase (3beta-HSD1) for substrate and inhibitor steroids relative to human 3beta-HSD2 is validated in MCF-7 tumor cells and related to subunit interactions. ongoing research,unassigned 2,0 1.1.1.145 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17408424&form=6&db=m Benign cortisol-secreting adrenocortical adenomas produce small amounts of androgens. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 1.1.1.145 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18623241&form=6&db=m Genomic analysis of cancer tissue reveals that somatic mutations commonly occur in a specific motif. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 1.1.1.145 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19270420&form=6&db=m Cushing's Syndrome by Left Adrenocortical Adenoma Synchronously Associated with Primary Aldosteronism by Right Adrenocortical Adenoma: Report of a Case. causal interaction,ongoing research,unassigned 4,1,0 1.1.1.145 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19620250&form=6&db=m Multiple Endocrine Neoplasia Type 1 (MEN1) knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 1.1.1.145 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27085553&form=6&db=m Expression of steroidogenic enzymes and their transcription factors in cortisol-producing adrenocortical adenomas: immunohistochemical analysis and quantitative real-time polymerase chain reaction studies. ongoing research,unassigned 1,0 1.1.1.145 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27670690&form=6&db=m DNA methylation is not involved in specific down-regulation of HSD3B2, NR4A1 and RARB genes in androgen-secreting cells of human adrenal cortex. diagnostic usage,ongoing research,unassigned 1,2,0 1.1.1.145 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29803408&form=6&db=m Up regulation of the steroid hormone synthesis regulator HSD3B2 is linked to early PSA recurrence in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.1.1.145 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31060224&form=6&db=m Genomic Profiling of the Steroidogenic Acute Regulatory Protein in Breast Cancer: In Silico Assessments and a Mechanistic Perspective. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 1.1.1.145 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31638934&form=6&db=m TMPRSS2-ERG fusions confer efficacy of enzalutamide in an in vivo bone tumor growth model. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 1.1.1.145 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34089832&form=6&db=m Intratumoral steroid profiling of adrenal cortisol-producing adenomas by liquid chromatography- mass spectrometry. ongoing research,unassigned 3,0 1.1.1.145 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18754758&form=6&db=m Alternative transcription initiation and splicing variants of the DHRS4 gene cluster. diagnostic usage,ongoing research,unassigned 3,4,0 1.1.1.145 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31983283&form=6&db=m m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells. causal interaction,ongoing research,unassigned 1,1,0 1.1.1.145 Ovarian Hyperstimulation Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29206944&form=6&db=m The direct and indirect effects of kisspeptin-54 on granulosa lutein cell function. causal interaction,diagnostic usage,unassigned 1,1,0 1.1.1.145 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1668983&form=6&db=m [Polycystic ovary syndrome as expression of 3-beta-hydroxysteroid dehydrogenase deficiency] causal interaction,diagnostic usage,unassigned 4,1,0 1.1.1.145 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14260992&form=6&db=m CONCURRENT 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY IN ADRENAL AND SCLEROCYSTIC OVARY. causal interaction,unassigned 3,0 1.1.1.145 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14764797&form=6&db=m The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 1.1.1.145 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23874725&form=6&db=m Differential regulation of human 3?-hydroxysteroid dehydrogenase type 2 for steroid hormone biosynthesis by starvation and cyclic AMP stimulation: studies in the human adrenal NCI-H295R cell model. ongoing research,unassigned 2,0 1.1.1.145 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26465200&form=6&db=m A Dietary Medium-Chain Fatty Acid, Decanoic Acid, Inhibits Recruitment of Nur77 to the HSD3B2 Promoter In Vitro and Reverses Endocrine and Metabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome. ongoing research,unassigned 3,0 1.1.1.145 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9294620&form=6&db=m Genetic variation of 3 beta-hydroxysteroid dehydrogenase type II in three racial/ethnic groups: implications for prostate cancer risk. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 1.1.1.145 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10417059&form=6&db=m GEN GEN: the genomic genetic analysis of androgen-metabolic genes and prostate cancer as a paradigm for the dissection of complex phenotypes. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 1.1.1.145 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10688862&form=6&db=m Hormonal carcinogenesis. ongoing research,therapeutic application,unassigned 3,1,0 1.1.1.145 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11912155&form=6&db=m Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 1.1.1.145 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15767343&form=6&db=m Thyroid cancer susceptibility and THRA1 and BAT-40 repeats polymorphisms. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 1.1.1.145 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17220347&form=6&db=m Variant in sex hormone-binding globulin gene and the risk of prostate cancer. diagnostic usage,ongoing research,unassigned 3,3,0 1.1.1.145 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17823934&form=6&db=m SRD5A2 and HSD3B2 polymorphisms are associated with prostate cancer risk and aggressiveness. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,2 1.1.1.145 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18479901&form=6&db=m Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor. diagnostic usage,ongoing research,unassigned 1,4,0 1.1.1.145 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19505920&form=6&db=m Single and multigenic analysis of the association between variants in 12 steroid hormone metabolism genes and risk of prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.1.1.145 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29369461&form=6&db=m Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer. causal interaction,ongoing research,unassigned 3,2,0 1.1.1.145 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29803408&form=6&db=m Up regulation of the steroid hormone synthesis regulator HSD3B2 is linked to early PSA recurrence in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.1.1.145 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30756097&form=6&db=m Androgen metabolism genes in prostate cancer health disparities. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.1.1.145 Puberty, Precocious http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16648810&form=6&db=m Association study of six activity SNPS in adrenal steroid hormone metabolism and IBM related genes with precocious puberty in Chinese girls. ongoing research,therapeutic application,unassigned 1,1,0 1.1.1.145 Puberty, Precocious http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19138897&form=6&db=m [Advances on related genes with sexual precocity in mammals] unassigned - 1.1.1.145 Puberty, Precocious http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30328339&form=6&db=m A rare variety of congenital adrenal hyperplasia with mosaic Klinefelter syndrome: a unique combination presenting with ambiguous genitalia and sexual precocity causal interaction,unassigned 3,0 1.1.1.145 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20534731&form=6&db=m Impact of differential P450c17 phosphorylation by cAMP stimulation and by starvation conditions on enzyme activities and androgen production in NCI-H295R cells. ongoing research,therapeutic application,unassigned 3,1,0 1.1.1.145 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22295121&form=6&db=m Role of AMP-activated protein kinase on steroid hormone biosynthesis in adrenal NCI-H295R cells. causal interaction,ongoing research,unassigned 1,2,0 1.1.1.145 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25970467&form=6&db=m Retinoic acid receptor beta and angiopoietin-like protein 1 are involved in the regulation of human androgen biosynthesis. unassigned - 1.1.1.145 steroid 21-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9120982&form=6&db=m Testis sparing surgery for steroid unresponsive testicular tumors of the adrenogenital syndrome. causal interaction,unassigned 4,0 1.1.1.145 steroid 21-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17496421&form=6&db=m A case of 3beta-hydroxysteroid dehydrogenase type II (HSD3B2) deficiency picked up by neonatal screening for 21-hydroxylase deficiency: difficulties and delay in etiologic diagnosis. causal interaction,diagnostic usage,unassigned 4,4,0 1.1.1.145 steroid 21-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22343390&form=6&db=m A Novel Homozygous Q334X Mutation in the HSD3B2 Gene Causing Classic 3?-Hydroxysteroid Dehydrogenase Deficiency: An Unexpected Diagnosis after a Positive Newborn Screen for 21-Hydroxylase Deficiency. causal interaction,unassigned 4,0 1.1.1.145 steroid 21-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26079780&form=6&db=m Severe Salt-Losing 3?-Hydroxysteroid Dehydrogenase Deficiency: Treatment and Outcomes of HSD3B2 c.35G>A Homozygotes. causal interaction,unassigned 4,0 1.1.1.145 steroid delta-isomerase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12428206&form=6&db=m Congenital adrenal hyperplasia due to 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase deficiency. causal interaction,unassigned 4,0 1.1.1.145 steroid delta-isomerase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15632317&form=6&db=m Molecular biology of the 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family. causal interaction,unassigned 4,0 1.1.1.145 steroid delta-isomerase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18252794&form=6&db=m Carboxyl-Terminal Mutations in 3{beta}-Hydroxysteroid Dehydrogenase Type II Cause Severe Salt-Wasting Congenital Adrenal Hyperplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.1.1.145 Tics http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31916094&form=6&db=m Androgens Modulate Rat Granulosa Cell Steroidogenesis. unassigned - 1.1.1.145 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23284679&form=6&db=m HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer. diagnostic usage,unassigned 3,0 1.1.1.145 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9722876&form=6&db=m Effect of 3-beta-hydroxysteroid dehydrogenase gene deletion on virulence and immunogenicity of different vaccinia viruses and their recombinants. ongoing research,therapeutic application,unassigned 3,1,0 1.1.1.145 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12915688&form=6&db=m Isolation of definitive zone and chromaffin cells based upon expression of CD56 (neural cell adhesion molecule) in the human fetal adrenal gland. diagnostic usage,ongoing research,unassigned 1,4,0 1.1.1.145 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31983283&form=6&db=m m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells. causal interaction,ongoing research,unassigned 1,1,0