3.4.23.5 0.0000000783 - Tb-9 at pH 3.5 and 25°C 754470 3.4.23.5 0.000000126 - TB-11 at pH 3.5 and 25°C 754470 3.4.23.5 0.000000182 - tasiamide B at pH 3.5 and 25°C 754470 3.4.23.5 0.00000059 - pepstatin A pH and temperature not specified in the publication 754469 3.4.23.5 0.000000693 - pepstatin A at pH 3.5 and 25°C 754470 3.4.23.5 0.000001 - pepstatin A IC50 of less than 1 nM, at pH 5.5 and 37°C 731454 3.4.23.5 0.0000025 - cathepsin D inhibitor from Streptomyces sp.MBR04 in 0.02M sodium citrate, pH 3.0, at 37°C 731168 3.4.23.5 0.00000329 - methyl (5S,8S,11S,12S,16S,19S,22R)-8-(3-amino-3-oxopropyl)-11,22-dibenzyl-12-hydroxy-7,19,21-trimethyl-16-(2-methylpropyl)-3,6,9,14,17,20-hexaoxo-1-phenyl-5-(propan-2-yl)-2-oxa-4,7,10,15,18,21-hexaazatricosan-23-oate at pH 3.5 and 25°C 754470 3.4.23.5 0.00000584 - methyl (2S)-1-[(2R,5S,8S,12S,13S)-2,13-dibenzyl-12-hydroxy-15-(3-[(methanesulfonyl)(methyl)amino]-5-[[(1R)-1-phenylethyl]carbamoyl]phenyl)-3,5-dimethyl-8-(2-methylpropyl)-4,7,10,15-tetraoxo-3,6,9,14-tetraazapentadecanan-1-oyl]pyrrolidine-2-carboxylate i.e. TB-13, pH and temperature not specified in the publication 754469 3.4.23.5 0.00000584 - TB-13 pH and temperature not specified in the publication 754469 3.4.23.5 0.0000086 - N2-[N-[(2-bromo-4,5-dimethoxyphenyl)acetyl]carbamimidoyl]-3-cyclohexyl-N-(4-fluoro-3-methoxybenzyl)-D-alaninamide at pH 5.5 and 37°C 731454 3.4.23.5 0.00001 - pepstatin A IC50 less than 0.00001 mM, pH and temperature not specified in the publication 712050 3.4.23.5 0.000015 - N1-[(2S,3S)-3-hydroxy-5-([(2S)-4-methyl-1-[(2-methylpropyl)amino]-1-oxopentan-2-yl]amino)-5-oxo-1-phenylpentan-2-yl]-5-[(methanesulfonyl)(methyl)amino]-N3-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide pH and temperature not specified in the publication 754469 3.4.23.5 0.000024 - N2-[N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl]-N-(4-fluoro-3-methoxybenzyl)-D-leucinamide at pH 5.5 and 37°C 731454 3.4.23.5 0.000027 - (5S,8S,11S,12S,16S,19S,22R)-8-(3-amino-3-oxopropyl)-11,22-dibenzyl-12-hydroxy-7,19,21-trimethyl-16-(2-methylpropyl)-3,6,9,14,17,20-hexaoxo-1-phenyl-5-(propan-2-yl)-2-oxa-4,7,10,15,18,21-hexaazatricosan-23-oic acid at pH 3.5 and 25°C 754470 3.4.23.5 0.000044 - 3-cyclohexyl-N2-[N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl]-N-[4-(1H-tetrazol-5-yl)benzyl]-D-alaninamide at pH 5.5 and 37°C 731454 3.4.23.5 0.000058 - N-(3,4-dimethoxybenzyl)-Na-[N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl]-D-phenylalaninamide at pH 5.5 and 37°C 731454 3.4.23.5 0.000067 - N-(3,4-dimethoxybenzyl)-N2-[N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl]-D-leucinamide at pH 5.5 and 37°C 731454 3.4.23.5 0.000081 - 3-cyclohexyl-N2-[N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl]-N-[3-fluoro-4-(1H-tetrazol-5-yl)benzyl]-D-alaninamide at pH 5.5 and 37°C 731454 3.4.23.5 0.000085 - 2-bromo-N-[(2S,3S)-4-[[2-(2,4-dichlorophenyl)ethyl][3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl]amino]-3-hydroxy-1-(3-phenoxyphenyl)butan-2-yl]-4,5-dimethoxybenzamide at pH 5.5 and 37°C 731454 3.4.23.5 0.00009 - (4'S)-3-(5,6-dihydro-2H-pyran-3-yl)-1-fluoro-7-(2-fluoropyridin-3-yl)-5'H-spiro[[1]benzopyrano[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine pH and temperature not specified in the publication 754614 3.4.23.5 0.000092 - 3-cyclohexyl-N2-[N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl]-N-[3-(1H-tetrazol-5-yl)benzyl]-D-alaninamide at pH 5.5 and 37°C 731454 3.4.23.5 0.000098 - 3-cyclohexyl-N2-[N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl]-N-(3-fluoro-4-methoxybenzyl)-D-alaninamide at pH 5.5 and 37°C 731454 3.4.23.5 0.000102 - methyl (5S,8S,11S,12S,16S,19S)-8-(3-amino-3-oxopropyl)-11-benzyl-12-hydroxy-7,19-dimethyl-16-(2-methylpropyl)-3,6,9,14,17-pentaoxo-1-phenyl-5-(propan-2-yl)-2-oxa-4,7,10,15,18-pentaazaicosan-20-oate at pH 3.5 and 25°C 754470 3.4.23.5 0.000108 - (5S,8S,11S,12S,16S,19S)-8-(3-amino-3-oxopropyl)-11-benzyl-12-hydroxy-7,19-dimethyl-16-(2-methylpropyl)-3,6,9,14,17-pentaoxo-1-phenyl-5-(propan-2-yl)-2-oxa-4,7,10,15,18-pentaazaicosan-20-oic acid at pH 3.5 and 25°C 754470 3.4.23.5 0.00012 - 3-cyclohexyl-N-(3,4-dimethoxybenzyl)-N2-[N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl]-D-alaninamide at pH 5.5 and 37°C 731454 3.4.23.5 0.000131 - (6S,9S,12S,13S,17S,20S,23R)-9-(3-amino-3-oxopropyl)-12,23-dibenzyl-13-hydroxy-2,2,8,20,22-pentamethyl-17-(2-methylpropyl)-4,7,10,15,18,21-hexaoxo-6-(propan-2-yl)-3-oxa-5,8,11,16,19,22-hexaazatetracosan-24-oic acid at pH 3.5 and 25°C 754470 3.4.23.5 0.00014 - N2-[N-[(2-bromo-4,5-dimethoxyphenyl)acetyl]carbamimidoyl]-3-cyclohexyl-N-[3-(1H-tetrazol-5-yl)benzyl]-D-alaninamide at pH 5.5 and 37°C 731454 3.4.23.5 0.00017 - 3-cyclohexyl-N-(3,4-difluorobenzyl)-N2-[N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl]-D-alaninamide at pH 5.5 and 37°C 731454 3.4.23.5 0.00017 - 3-cyclohexyl-N2-[N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl]-N-(4-fluoro-3-methoxybenzyl)-D-alaninamide at pH 5.5 and 37°C 731454 3.4.23.5 0.00019 - methyl (6S,9S,12S,13S,17S,20S,23R)-9-(3-amino-3-oxopropyl)-12,23-dibenzyl-13-hydroxy-2,2,8,20,22-pentamethyl-17-(2-methylpropyl)-4,7,10,15,18,21-hexaoxo-6-(propan-2-yl)-3-oxa-5,8,11,16,19,22-hexaazatetracosan-24-oate at pH 3.5 and 25°C 754470 3.4.23.5 0.000196 - methyl (5S,8S,11S,12S,16S)-8-(3-amino-3-oxopropyl)-11-benzyl-12-hydroxy-7-methyl-16-(2-methylpropyl)-3,6,9,14-tetraoxo-1-phenyl-5-(propan-2-yl)-2-oxa-4,7,10,15-tetraazaheptadecan-17-oate at pH 3.5 and 25°C 754470 3.4.23.5 0.00021 - (5Z)-5-[4-[(4-benzoyl-3-hydroxy-2-propylphenoxy)methyl]benzylidene]-2-thioxo-1,3-thiazolidin-4-one at pH 5.5 and 37°C 731454 3.4.23.5 0.00024 - N2-[N-[(2-bromo-4,5-dimethoxyphenyl)acetyl]carbamimidoyl]-N-[3-(1H-tetrazol-5-yl)benzyl]-D-leucinamide at pH 5.5 and 37°C 731454 3.4.23.5 0.00025 - 3,5-dichloro-2-[[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino]-N-[4-[(6-ethoxy-1,3-benzothiazol-2-yl)sulfanyl]phenyl]benzamide at pH 5.5 and 37°C 731454 3.4.23.5 0.00028 - N2-[N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl]-N-[2-fluoro-3-(1H-tetrazol-5-yl)benzyl]-D-leucinamide at pH 5.5 and 37°C 731454 3.4.23.5 0.00032 - Na-[N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl]-N-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-D-phenylalaninamide at pH 5.5 and 37°C 731454 3.4.23.5 0.000353 - N1-[(2S,3S)-3-hydroxy-5-[[(2S)-1-[[(3-methoxyphenyl)methyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxo-1-phenylpentan-2-yl]-5-[(methanesulfonyl)(methyl)amino]-N3-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide pH and temperature not specified in the publication 754469 3.4.23.5 0.00037 - N2-[N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl]-N-[3-(1H-tetrazol-5-yl)benzyl]-D-leucinamide at pH 5.5 and 37°C 731454 3.4.23.5 0.000407 - methyl (6S,9S,12S,13S,17S,20S)-9-(3-amino-3-oxopropyl)-12-benzyl-13-hydroxy-2,2,8,20-tetramethyl-17-(2-methylpropyl)-4,7,10,15,18-pentaoxo-6-(propan-2-yl)-3-oxa-5,8,11,16,19-pentaazahenicosan-21-oate at pH 3.5 and 25°C 754470 3.4.23.5 0.00044 - N-[N-(3,4-dichlorobenzyl)carbamimidoyl]-2-(4,5-dimethoxy-2-nitrophenyl)acetamide at pH 5.5 and 37°C 731454 3.4.23.5 0.00051 - N2-[N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl]-N-[4-(1H-tetrazol-5-yl)benzyl]-D-leucinamide at pH 5.5 and 37°C 731454 3.4.23.5 0.00066 - (4'S)-7-(2-fluoropyridin-3-yl)-3-(2-fluoropyridin-4-yl)-5'H-spiro[[1]benzopyrano[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine pH and temperature not specified in the publication 754614 3.4.23.5 0.00069 - N2-[N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl]-N-[3-fluoro-4-(1H-tetrazol-5-yl)benzyl]-D-leucinamide at pH 5.5 and 37°C 731454 3.4.23.5 0.000884 - N1-[(2S,3S)-5-[[(2S)-1-(cyclopropylamino)-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-5-oxo-1-phenylpentan-2-yl]-5-[(methanesulfonyl)(methyl)amino]-N3-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide pH and temperature not specified in the publication 754469 3.4.23.5 0.000903 - (6S,9S,12S,13S,17S,20S)-9-(3-amino-3-oxopropyl)-12-benzyl-13-hydroxy-2,2,8,20-tetramethyl-17-(2-methylpropyl)-4,7,10,15,18-pentaoxo-6-(propan-2-yl)-3-oxa-5,8,11,16,19-pentaazahenicosan-21-oic acid at pH 3.5 and 25°C 754470 3.4.23.5 0.0015 - N-[N-(4-chlorobenzyl)carbamimidoyl]-2-(4,5-dimethoxy-2-nitrophenyl)acetamide at pH 5.5 and 37°C 731454 3.4.23.5 0.0019 - 2-(3,4-dimethoxyphenyl)-N-[N-(4-methylbenzyl)carbamimidoyl]acetamide at pH 5.5 and 37°C 731454 3.4.23.5 0.0027 - (4'S)-3-(5,6-dihydro-2H-pyran-3-yl)-7-[5-(prop-1-yn-1-yl)pyridin-3-yl]-5'H-spiro[[1]benzopyrano[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine pH and temperature not specified in the publication 754614 3.4.23.5 0.0027 - N-[N-(3,4-dimethoxybenzyl)carbamimidoyl]-2-(4,5-dimethoxy-2-nitrophenyl)acetamide at pH 5.5 and 37°C 731454 3.4.23.5 0.003 - N-[N-(2-chlorobenzyl)carbamimidoyl]-2-(4,5-dimethoxy-2-nitrophenyl)acetamide at pH 5.5 and 37°C 731454 3.4.23.5 0.0036 - (4'S)-7-[5-(cyclopropylethynyl)pyridin-3-yl]-3-(3,6-dihydro-2H-pyran-4-yl)-5'H-spiro[[1]benzopyrano[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine pH and temperature not specified in the publication 754614 3.4.23.5 0.0044 - 3-[5-[(4'S)-2'-amino-3-(3,6-dihydro-2H-pyran-4-yl)-5'H-spiro[[1]benzopyrano[2,3-c]pyridine-5,4'-[1,3]oxazol]-7-yl]pyridin-3-yl]prop-2-yn-1-ol pH and temperature not specified in the publication 754614 3.4.23.5 0.0045 - (4'S)-3-(2-fluoropyridin-4-yl)-7-[5-(prop-1-yn-1-yl)pyridin-3-yl]-5'H-spiro[[1]benzopyrano[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine pH and temperature not specified in the publication 754614 3.4.23.5 0.005 - (6S,9S,12S,13S,17S)-9-(3-amino-3-oxopropyl)-12-benzyl-13-hydroxy-2,2,8-trimethyl-17-(2-methylpropyl)-4,7,10,15-tetraoxo-6-(propan-2-yl)-3-oxa-5,8,11,16-tetraazaoctadecan-18-oic acid IC50 above 0.005 mM, at pH 3.5 and 25°C 754470 3.4.23.5 0.0059 - (4'S)-3-(3,6-dihydro-2H-pyran-4-yl)-7-[5-(prop-1-yn-1-yl)pyridin-3-yl]-5'H-spiro[[1]benzopyrano[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine pH and temperature not specified in the publication 754614 3.4.23.5 0.0061 - N-(N-benzylcarbamimidoyl)-2-(2-chloro-5-methoxyphenyl)acetamide at pH 5.5 and 37°C 731454 3.4.23.5 0.006384 - (5S,8S,11S,12S,16S)-8-(3-amino-3-oxopropyl)-11-benzyl-12-hydroxy-7-methyl-16-(2-methylpropyl)-3,6,9,14-tetraoxo-1-phenyl-5-(propan-2-yl)-2-oxa-4,7,10,15-tetraazaheptadecan-17-oic acid at pH 3.5 and 25°C 754470 3.4.23.5 0.0083 - Na-[N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl]-N-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-L-phenylalaninamide at pH 5.5 and 37°C 731454 3.4.23.5 0.01 - 4-([N-[(benzyloxy)carbonyl]-L-valyl-N2-methyl-L-glutaminyl]amino)-2,4,5-trideoxy-5-phenyl-L-threo-pentonic acid IC50 above 0.01 mM, at pH 3.5 and 25°C 754470 3.4.23.5 0.01 - methyl (6S,9S,12S,13S,17S)-9-(3-amino-3-oxopropyl)-12-benzyl-13-hydroxy-2,2,8-trimethyl-17-(2-methylpropyl)-4,7,10,15-tetraoxo-6-(propan-2-yl)-3-oxa-5,8,11,16-tetraazaoctadecan-18-oate IC50 above 0.01 mM, at pH 3.5 and 25°C 754470 3.4.23.5 0.01 - N-(N-benzylcarbamimidoyl)-2-(4,5-dimethoxy-2-nitrophenyl)acetamide at pH 5.5 and 37°C 731454 3.4.23.5 0.012 - (4'S)-3-(3,6-dihydro-2H-pyran-4-yl)-7-[5-[(3-methyloxetan-3-yl)ethynyl]pyridin-3-yl]-5'H-spiro[[1]benzopyrano[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine pH and temperature not specified in the publication 754614 3.4.23.5 0.015 - (4'S)-7-(2-fluoropyridin-3-yl)-3-(2-fluoropyridin-4-yl)-5'H-spiro[[1]benzopyrano[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine pH and temperature not specified in the publication 754614 3.4.23.5 0.018 - N-(N-benzylcarbamimidoyl)-4-(4,5-dimethoxy-2-nitrophenyl)butanamide at pH 5.5 and 37°C 731454 3.4.23.5 0.025 - N-(N-benzylcarbamimidoyl)-3-(3,4-dimethoxyphenyl)propanamide at pH 5.5 and 37°C 731454 3.4.23.5 0.029 - N-[N-(4-aminobenzyl)carbamimidoyl]-2-(3,4-dimethoxyphenyl)acetamide at pH 5.5 and 37°C 731454 3.4.23.5 0.072 - (4'S)-3-chloro-7-[5-(prop-1-yn-1-yl)pyridin-3-yl]-5'H-spiro[[1]benzopyrano[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine pH and temperature not specified in the publication 754614 3.4.23.5 0.13 - (4'S)-3-chloro-7-(5-fluoropyridin-3-yl)-5'H-spiro[[1]benzopyrano[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine pH and temperature not specified in the publication 754614 3.4.23.5 0.31 - N-[(4'S)-2'-amino-3-cyclopropyl-5'H-spiro[[1]benzopyrano[2,3-c]pyridine-5,4'-[1,3]oxazol]-7-yl]-5-chloropyridine-2-carboxamide pH and temperature not specified in the publication 754614 3.4.23.5 0.48 - N-[(4'S)-2'-amino-3-(5,6-dihydro-2H-pyran-3-yl)-5'H-spiro[[1]benzopyrano[2,3-c]pyridine-5,4'-[1,3]oxazol]-7-yl]-5-chloropyridine-2-carboxamide pH and temperature not specified in the publication 754614 3.4.23.5 0.64 - N-[(4'S)-2'-amino-3-methyl-5'H-spiro[[1]benzopyrano[2,3-c]pyridine-5,4'-[1,3]oxazol]-7-yl]-5-chloropyridine-2-carboxamide pH and temperature not specified in the publication 754614 3.4.23.5 1 - N-[(4'S)-2'-amino-3-(3,6-dihydro-2H-pyran-4-yl)-5'H-spiro[[1]benzopyrano[2,3-c]pyridine-5,4'-[1,3]oxazol]-7-yl]-5-chloropyridine-2-carboxamide pH and temperature not specified in the publication 754614 3.4.23.5 1.1 - N-[(4'S)-2'-amino-3-chloro-5'H-spiro[[1]benzopyrano[2,3-c]pyridine-5,4'-[1,3]oxazol]-7-yl]-5-chloropyridine-2-carboxamide pH and temperature not specified in the publication 754614 3.4.23.5 1.2 - N-[(4'S)-2'-amino-3-methoxy-5'H-spiro[[1]benzopyrano[2,3-c]pyridine-5,4'-[1,3]oxazol]-7-yl]-5-chloropyridine-2-carboxamide pH and temperature not specified in the publication 754614