3.4.17.21 0.00000006 - (S)-2-(3-((S)-1-carboxy-(4-iodobenzamido)pentyl)ureido)pentanedioic acid - 699452 3.4.17.21 0.0000001 - (2S)-2-[[(2-[4-[(tert-butoxycarbonyl)amino]phenyl]ethoxy)(hydroxy)phosphoryl]methyl]pentanedioic acid - 683948 3.4.17.21 0.0000001 - (S)-2-(phosphonomethyl)-pentanedioic acid more potent than the R-isomer, IC50: 0.0000001 mM 669776 3.4.17.21 0.0000002 - (2S)-2-([hydroxy[2-(4-hydroxyphenyl)ethoxy]phosphoryl]methyl)pentanedioic acid - 683948 3.4.17.21 0.0000003 - 2-(phosphonomethyl)pentanedioic acid IC50: 0.3 nM 656455 3.4.17.21 0.0000004 - 2-(phosphonomethyl)pentanedioic acid - 683948 3.4.17.21 0.0000005 - (S)-2-(3-((S)-1-carboxy-2-(4-hydroxy-3-iodophenyl)ethyl)ureido)pentanedioic acid - 699452 3.4.17.21 0.0000005 - 2-[[(2,4-dicarboxybutyl)(hydroxy)phosphoryl]methyl]pentanedioic acid IC50: 0.5 nM 656455 3.4.17.21 0.00000068 - S-2-((2-(S-4-amino-4-carboxybutanamido)-S-2-carboxyethoxy)-hydroxyphosphorylamino)-pentanedioic acid - 709648 3.4.17.21 0.0000007 - (2S)-2-([[2-(4-[[N-(tert-butoxycarbonyl)glycyl]amino]phenyl)ethoxy](hydroxy)phosphoryl]methyl)pentanedioic acid - 683948 3.4.17.21 0.0000008 - (2S)-2-[[hydroxy(2-phenylethoxy)phosphoryl]methyl]pentanedioic acid - 683948 3.4.17.21 0.000001 - 2-[[(2-carboxyethyl)(hydroxy)phosphoryl]methyl]pentanedioic acid IC50: 1 nM 655290 3.4.17.21 0.0000015 - 2-[[(2-carboxypropyl)(hydroxy)phosphoryl]methyl]pentanedioic acid IC50: 1.5 nM 656455 3.4.17.21 0.000002 - (S)-2-(3-((S)-1-carboxy-5-(3-(4-bromophenyl)ureido)pentyl)ureido)pentanedioic acid - 709440 3.4.17.21 0.000002 - (S)-2-(3-((S)-1-carboxy-5-(4-chlorobenzylamino)pentyl)ureido)pentanedioic acid - 709440 3.4.17.21 0.000002 - 2-[[(2-carboxy-3-phenylpropyl)(hydroxy)phosphoryl]methyl]pentanedioic acid IC50: 2 nM 656455 3.4.17.21 0.000002 - 2-[[(2-carboxy-4-phenylbutyl)(hydroxy)phosphoryl]methyl]pentanedioic acid IC50: 2 nM 655290 3.4.17.21 0.000002 - diphenyl 2-[[[2-[4-([[7-(diethylamino)-2-oxo-2H-chromen-3-yl]carbamoyl]amino)phenyl]ethoxy](hydroxy)phosphoryl]methyl]pentanedioate - 683948 3.4.17.21 0.000003 - (S)-2-(3-((S)-1-carboxy-5-(3-(4-fluorophenyl)ureido)pentyl)ureido)pentanedioic acid - 709440 3.4.17.21 0.000003 - 2-[(hydroxy[[(4-methoxyphenyl)amino]methyl]phosphoryl)methyl]pentanedioic acid IC50: 3 nM 656455 3.4.17.21 0.000003 - 2-{[2-Carboxy-3-(4-methoxy-phenylamino)-propyl]-hydroxy-phosphinoylmethyl}-pentanedioic acid IC50: 3 nM 655290 3.4.17.21 0.000004 - (2S)-2-[[hydroxy(3-phenylpropoxy)phosphoryl]methyl]pentanedioic acid - 683948 3.4.17.21 0.000004 - (2S)-2-[[[2-[4-(acetylamino)phenyl]ethoxy](hydroxy)phosphoryl]methyl]pentanedioic acid - 683948 3.4.17.21 0.000004 - (S)-2-(3-((S)-1-carboxy-5-(3-(4-chlorophenyl)ureido)pentyl)ureido)pentanedioic acid - 709440 3.4.17.21 0.000004 - 2-[[(anilinomethyl)(hydroxy)phosphoryl]methyl]pentanedioic acid IC50: 4 nM 656455 3.4.17.21 0.0000051 - 2-(phosphonomethyl)pentanedioic acid IC50: 5.1 nM 656453 3.4.17.21 0.00000674 - 2-(phosphonomethyl)-pentanedioic acid 2-PMPA, GCPIII IC50: 94 nM, GCPII IC50: 6.74 nM 669923 3.4.17.21 0.0000069 - Cys-PSI[C-O-S]-Glu IC50: 6.9 nM 656453 3.4.17.21 0.000007 - N-(tert-butoxycarbonyl)glycyl-N-[4-[2-([[(2S)-2,4-dicarboxybutyl](hydroxy)phosphoryl]oxy)ethyl]phenyl]-L-prolinamide - 683948 3.4.17.21 0.000008 - N-(tert-butoxycarbonyl)glycylglycyl-N-[4-[2-([[(2S)-2,4-dicarboxybutyl](hydroxy)phosphoryl]oxy)ethyl]phenyl]glycinamide - 683948 3.4.17.21 0.00001 - (S)-2-(3-((S)-1-carboxy-5-(3-(4-iodophenyl)ureido)pentyl)ureido)pentanedioic acid - 709440 3.4.17.21 0.00001 - (S)-2-(3-((S)-1-carboxy-5-(4-iodophenylsulfonamido)pentyl)-ureido)pentanedioic acid - 709440 3.4.17.21 0.00001 - 2-([hydroxy[hydroxy(pyridin-4-yl)methyl]phosphoryl]methyl)pentanedioic acid IC50: 10 nM 656455 3.4.17.21 0.000012 - (S)-2-(3-((S)-1-carboxy-5-(3-phenylureido)pentyl)ureido)pentanedioic acid - 709440 3.4.17.21 0.000014 - (S)-2-(3-((R)-1-carboxy-2-(4-fluorobenzylthio)ethyl)ureido)pentanedioic acid - 699452 3.4.17.21 0.000014 - 3-(1-carboxy-4-mercaptobutoxy)benzoic acid IC50: 14 nM 669801 3.4.17.21 0.000014 - N-[[(2S)-2-[[(6S)-6-amino-6-carboxy-3-oxohexyl]amino]-2-carboxyethoxy](hydroxy)phosphoryl]-L-glutamic acid 37°C, pH 7.4 753547 3.4.17.21 0.000014 - S-2-((2-(S-4-(4-18F-fluorobenzamido)-4-carboxybutanamido)-S-2-carboxyethoxy)hydroxyphosphorylamino)-pentanedioic acid - 709648 3.4.17.21 0.000015 - 3-(2-carboxy-5-mercaptopentyl)benzoic acid IC50: 15 nM 669801 3.4.17.21 0.000016 - 2-[[[(3-fluorophenyl)(hydroxy)methyl](hydroxy)phosphoryl]methyl]pentanedioic acid IC50: 16 nM 656455 3.4.17.21 0.000016 - N-(4-fluorobenzoyl)-L-isoleucyl-O-[[[(1S)-1,3-dicarboxypropyl]amino](hydroxy)phosphoryl]-L-serine 37°C, pH 7.4 753547 3.4.17.21 0.000016 - N-(4-fluorobenzoyl)-L-valyl-O-[[[(1S)-1,3-dicarboxypropyl]amino](hydroxy)phosphoryl]-L-serine 37°C, pH 7.4 753547 3.4.17.21 0.000017 - (S)-2-(3-((R)-1-carboxy-(2-methylthio)ethyl)ureido)pentanedioic acid - 699452 3.4.17.21 0.000018 - (9S,13S)-1-(3-iodophenyl)-3,11-dioxo-2,4,10,12-tetraazapentadecane-9,13,15-tricarboxylic acid - 709440 3.4.17.21 0.000022 - (S)-2-(3-((S)-1-carboxy-5-(4-iodobenzylamino)pentyl)ureido)-pentanedioic acid - 709440 3.4.17.21 0.000029 - (t-Bu)Cys-PSI[C-O]-Glu IC50: 29 nM 656453 3.4.17.21 0.00003 - (R)-2-(phosphonomethyl)-pentanedioic acid less potent than the S-isomer, IC50: 0.000030 mM 669776 3.4.17.21 0.000032 - 3-[(1-carboxy-4-mercaptobutyl)thio]benzoic acid IC50: 32 nM 669801 3.4.17.21 0.000034 - (S)-2-(hydroxypentafluorophenylmethyl-phosphinoylmethyl)pentanedioic acid 40fold more potent than the R-isomer, IC50: 0.000034 mM 669776 3.4.17.21 0.000035 - N-[[(2S)-2-benzamido-2-carboxyethoxy](hydroxy)phosphoryl]-L-glutamic acid 37°C, pH 7.4 753547 3.4.17.21 0.000037 - (S)-2-(3-((S)-1-carboxy-5-(2-iodobenzylamino)pentyl)ureido)-pentanedioic acid - 709440 3.4.17.21 0.000043 - (S)-2-(3-((S)-1-carboxy-5-(4-bromobenzylamino)pentyl)ureido)pentanedioic acid - 709440 3.4.17.21 0.000047 - Glu-PSI[C-O]-Glu IC50: 47 nM 656453 3.4.17.21 0.000049 - 2-[[(3,5-difluorobenzyl)(hydroxy)phosphoryl]methyl]pentanedioic acid IC50: 49 nM 656455 3.4.17.21 0.000053 - 2-[[benzyl(hydroxy)phosphoryl]methyl]pentanedioic acid IC50: 53 nM 656455 3.4.17.21 0.000055 - 2-([hydroxy[3-(trifluoromethyl)benzyl]phosphoryl]methyl)pentanedioic acid IC50: 55 nM 655290 3.4.17.21 0.000055 - 2-([hydroxy[hydroxy(phenyl)methyl]phosphoryl]methyl)pentanedioic acid IC50: 55 nM 656455 3.4.17.21 0.000055 - 2-[[[3,5-bis(trifluoromethyl)benzyl](hydroxy)phosphoryl]methyl]pentanedioic acid IC50: 55 nM 656455 3.4.17.21 0.000059 - 2-[[hydroxy(3-nitrobenzyl)phosphoryl]methyl]pentanedioic acid IC50 59 nM 655290 3.4.17.21 0.000059 - 2-[[[(benzylamino)methyl](hydroxy)phosphoryl]methyl]pentanedioic acid IC50: 59 nM 656455 3.4.17.21 0.000063 - 4-(2-carboxy-5-mercaptopentyl)benzoic acid IC50: 63 nM 669801 3.4.17.21 0.000064 - 2-[[(4-fluorobenzyl)(hydroxy)phosphoryl]methyl]pentanedioic acid IC50: 64 nM 655290 3.4.17.21 0.000068 - 2-[[hydroxy(4-methylbenzyl)phosphoryl]methyl]pentanedioic acid IC50: 68 nM 656455 3.4.17.21 0.00007 - 2-[[(3-fluorobenzyl)(hydroxy)phosphoryl]methyl]pentanedioic acid IC50: 70 nM 655290 3.4.17.21 0.00007 - 2-[[benzyl(hydroxy)phosphoryl]methyl]pentanedioic acid IC50: 70 nM 655290 3.4.17.21 0.000082 - 2-[[hydroxy(pentafluorobenzyl)phosphoryl]methyl]pentanedioic acid IC50: 82 nM. Significantly prevents neurodegeneration in a middle cerebral artery occlusion model of cerebral ischemia. In the chronic constrictive model of neuropathic pain, the inhibitor sifnificantly attenuats the hypersensitivity observed with saline- 656455 3.4.17.21 0.00009 - 2-(3-mercaptopropyl)-pentanedioic acid i.e. 2-MPPA, IC50: 90 nM 669801 3.4.17.21 0.00009 - 2-(3-mercaptopropyl)pentanedioic acid IC50: 90 nM. Orally bioavailable in rats 656461 3.4.17.21 0.00009 - 2-[[hydroxy(4-methoxybenzyl)phosphoryl]methyl]pentanedioic acid IC50: 90 nM 656455 3.4.17.21 0.000094 - 2-(phosphonomethyl)-pentanedioic acid 2-PMPA, GCPIII IC50: 94 nM, GCPII IC50: 6.74 nM 669923 3.4.17.21 0.000095 - 2-[[[3-(benzyloxy)-2-methyl-3-oxopropyl](hydroxy)phosphoryl]methyl]pentanedioic acid IC50: 95 nM 656455 3.4.17.21 0.000102 - pyropheophorbide-a conjugate pH 7.4, 37°C 710460 3.4.17.21 0.00012 - 3-(2-carboxy-3-phosphonopropyl)benzoic acid IC50: 120 nM 669801 3.4.17.21 0.000143 - 2-[[(3-aminobenzyl)(hydroxy)phosphoryl]methyl]pentanedioic acid IC50: 143 nM 656455 3.4.17.21 0.000149 - 2-[[hydroxy(2-phenylethyl)phosphoryl]methyl]pentanedioic acid IC50: 149 nM 656455 3.4.17.21 0.00015 - 2-[[hydroxy(2-phenylethyl)phosphoryl]methyl]pentanedioic acid IC50: 150 nM 655290 3.4.17.21 0.000154 - (S)-2-(3-((S)-1-carboxy-5-(naphthalen-1-ylmethylamino)pentyl)-ureido)pentanedioic acid - 709440 3.4.17.21 0.000156 - 2-[[(2-fluorobenzyl)(hydroxy)phosphoryl]methyl]pentanedioic acid IC50: 156 nM 656455 3.4.17.21 0.000168 - N-[[([1,1'-biphenyl]-4-yl)methoxy](hydroxy)phosphoryl]-L-glutamic acid 37°C, pH 7.4 753547 3.4.17.21 0.000175 - 2-(phosphonomethyl)-4-(5H-tetrazol-5-yl)butanoic acid IC50: 175 nM 656455 3.4.17.21 0.00018 - N-[hydroxy(4-phenylbutoxy)phosphoryl]-L-glutamic acid 37°C, pH 7.4 753547 3.4.17.21 0.000185 - 2-(phosphonomethyl)hexanedioic acid IC50: 185 nM 656455 3.4.17.21 0.000185 - 2-(phosphonomethyl)hexanoic acid IC50: 185 nM 655290 3.4.17.21 0.000199 - 4-phenyl-2-(phosphonomethyl)butanoic acid IC50: 199 nM 655290, 656455 3.4.17.21 0.00023 - 2-[[hydroxy(3-phenylpropyl)phosphoryl]methyl]pentanedioic acid IC50: 230 nM 655290 3.4.17.21 0.000245 - (S)-2-(3-((S)-1-carboxy-5-(2-chlorobenzylamino)pentyl)ureido)pentanedioic acid - 709440 3.4.17.21 0.000277 - (S)-2-(3-((S)-1-carboxy-5-(3-chlorobenzylamino)pentyl)ureido)pentanedioic acid - 709440 3.4.17.21 0.0003 - (2S)-2-([[2-(4-fluorophenyl)ethoxy](hydroxy)phosphoryl]methyl)pentanedioic acid - 683948 3.4.17.21 0.000335 - 4-cyano-2-(phosphonomethyl)butanoic acid IC50: 335 nM 656455 3.4.17.21 0.00036 - 2-[[hydroxy(propyl)phosphoryl]methyl]pentanedioic acid IC50: 360 nM 656455 3.4.17.21 0.000443 - (S)-2-(3-((S)-1-carboxy-5-(3-iodobenzylamino)pentyl)ureido)-pentanedioic acid - 709440 3.4.17.21 0.000498 - (S)-2-(3-((S)-5-amino-1-carboxypentyl)ureido)pentanedioic acid - 709440 3.4.17.21 0.000508 - 2-(3-hydroxybenzyl)-3-phosphonopropanoic acid IC50: 508 nM 655290 3.4.17.21 0.000508 - 4-(3-hydroxyphenyl)-2-(phosphonomethyl)butanoic acid IC50: 508 nM 656455 3.4.17.21 0.000548 - 2-benzyl-3-phosphonopropanoic acid IC50: 548 nM 655290, 656455 3.4.17.21 0.00056 - 2-[[hydroxy(propyl)phosphoryl]methyl]pentanedioic acid IC50: 560 nM 655290 3.4.17.21 0.00064 - 3-(2-carbamoyl-5-mercaptopentyl)benzoic acid IC50: 640 nM 669801 3.4.17.21 0.0007 - N-[[(2R)-2-benzamido-2-carboxyethoxy](hydroxy)phosphoryl]-L-glutamic acid 37°C, pH 7.4 753547 3.4.17.21 0.00073 - 3-(5-mercapto-2-methoxycarbonylpentyl)benzoic acid IC50: 730 nM 669801 3.4.17.21 0.0012 - (S)-2-(3-((S)-1-carboxy-5-(4-fluorobenzylamino)pentyl)ureido)pentanedioic acid - 709440 3.4.17.21 0.0014 - (R)-2-(hydroxypentafluorophenylmethyl-phosphinoylmethyl)pentanedioic acid 40fold less potent than the S-isomer, IC50: 0.0014 mM 669776 3.4.17.21 0.0014 - 2-benzyl-5-mercaptopentanoic acid IC50: 1400 nM 669801 3.4.17.21 0.0017 - 2-(2-carboxy-5-mercaptopentyl)benzoic acid IC50: 1700 nM 669801 3.4.17.21 0.0018 - 2-(3-cyanobenzyl)-5-mercaptopentanoic acid IC50: 1800 nM 669801 3.4.17.21 0.0018 - N-[(2-benzamidoethoxy)(hydroxy)phosphoryl]-L-glutamic acid 37°C, pH 7.4 753547 3.4.17.21 0.002 - 3-(2-oxotetrahydro-thiopyran-3-yl)propionic acid pH not specified in the publication, temperature not specified in the publication 732312 3.4.17.21 0.0022 - 2-(3-carbamoylbenzyl)-5-mercaptopentanoic acid IC50: 2200 nM 669801 3.4.17.21 0.0022 - 2-(phosphonomethyl)succinic acid IC50: 2200 nM 656455 3.4.17.21 0.0024 - 3-[2-carboxy-3-(hydroxypentafluorophenylmethylphosphinoyl)propyl]benzoic acid IC50: 2400 nM 669801 3.4.17.21 0.0027 - 3-(2-carboxy-5-mercaptopentyl)benzoic acid methyl ester IC50: 2700 nM 669801 3.4.17.21 0.00293 - 2-[[hydroxy(phenyl)phosphoryl]methyl]pentanedioic acid IC50: 2930 nM 656455 3.4.17.21 0.00296 - (S)-2-(3-((S)-5-(benzylamino)-1-carboxypentyl)ureido)pentanedioic acid - 709440 3.4.17.21 0.003 - (S)-2-(3-(4-iodobenzyl)ureido)pentanedioic acid - 709440 3.4.17.21 0.0038 - Asp-PSI[C-O]-Asp IC50: 0.0038 mM 656453 3.4.17.21 0.015 - 2-(3-carboxybenyl)succinic acid IC50: 0.015 mM 669801 3.4.17.21 0.015 - 3-(2-carboxy-3-hydroxycarbamoylpropyl)benzoic acid IC50: 0.015 mM 669801 3.4.17.21 0.02 - 3-(2-carboxy-5-mercaptosulfanylpentyl)benzoic acid IC50: 0.02 mM 669801 3.4.17.21 0.02 - 3-(2-carboxy-5-tritylsulfanylpentyl)benzoic acid IC50: 0.02 mM 669801 3.4.17.21 0.0461 - Asp-PSI[C-O-S]-Glu IC50: 0.0461 mM 656453