3.2.1.114 0.000005 - swainsonine in 50 mM sodium acetate buffer pH 5.8, at 37°C 714909 3.2.1.114 0.00001 - Mannostatin A very potent inhibitor, competitive, IC50: about 10 nM with 4-nitrophenyl alpha-D-mannoside as substrate, about 90 nM with GlcNAc(Man)5GlcNAc as substrate, equally potent as swainsonine 646629 3.2.1.114 0.00001 - swainsonine alpha-mannosidase III, IC50: 10 nM 646644 3.2.1.114 0.00001 - swainsonine extracted from endothelial cells HCEC 696732 3.2.1.114 0.000017 - swainsonine - 682766 3.2.1.114 0.00002 - swainsonine extracted from human glioblastoma cells LNZ308 696732 3.2.1.114 0.000029 - 1-(4-methylphenyl)-2-[(1S,2R,5R,8R,8aR)-1,2,8-trihydroxyoctahydroindolizin-5-yl]ethanone pH 5.75, 25°C 708117 3.2.1.114 0.000029 - 1-(4-tert-butylphenyl)-2-[(1S,2R,5R,8R,8aR)-1,2,8-trihydroxyoctahydroindolizin-5-yl]ethanone pH 5.75, 25°C 708117 3.2.1.114 0.00003 - 1-phenyl-2-[(1S,2R,5R,8R,8aR)-1,2,8-trihydroxyoctahydroindolizin-5-yl]ethanone pH 5.75, 25°C 708117 3.2.1.114 0.000037 - swainsonine pH 5.75, 25°C 708117 3.2.1.114 0.000044 - (1S,2R,5S,8R,8aR)-5-[2-(4-tert-butylphenyl)ethyl]octahydroindolizine-1,2,8-triol pH 5.75, 25°C 708117 3.2.1.114 0.00005 - swainsonine extracted from human glioblastoma cells LN18 696732 3.2.1.114 0.00009 0.0001 D-mannonolactam amidrazone equally as effective as mannostatin A, IC50: 90-100 nM 646590 3.2.1.114 0.00013 - Mannostatin A in 50 mM sodium acetate buffer pH 5.8, at 37°C 714909 3.2.1.114 0.00025 - (1S,2R,5R,8R,8aR)-5-[2-(4-tert-butylphenyl)ethyl]octahydroindolizine-1,2,8-triol pH 5.75, 25°C 708117 3.2.1.114 0.00025 - 1-(4-tert-butylphenyl)-2-[(1S,2R,5S,8R,8aR)-1,2,8-trihydroxyoctahydroindolizin-5-yl]ethanone pH 5.75, 25°C 708117 3.2.1.114 0.0004 - D-mannonolactam amidrazone IC50: 400 nM 646590 3.2.1.114 0.0005 - (3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one extracted from endothelial cells HCEC 696732 3.2.1.114 0.0005 - (3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one extracted from human glioblastoma cells LNZ308 696732 3.2.1.114 0.00075 - (3R,4R,5S)-5-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]-3,4-dihydroxy-1-methylpyrrolidin-2-one extracted from endothelial cells HCEC 696732 3.2.1.114 0.002 - (3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one extracted from human glioblastoma cells LN18 696732 3.2.1.114 0.0075 - (3R,4R,5S)-5-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]-3,4-dihydroxy-1-methylpyrrolidin-2-one extracted from human glioblastoma cells LNZ308 696732 3.2.1.114 0.014 - 8-epi-lentiginosine - 682772 3.2.1.114 0.025 - (2S,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol extracted from endothelial cells HCEC 696732 3.2.1.114 0.05 - (2S,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol extracted from human glioblastoma cells LN18 696732 3.2.1.114 0.05 - (2S,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol extracted from human glioblastoma cells LNZ308 696732 3.2.1.114 0.05 - (3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidin-2-one extracted from human glioblastoma cells LNZ308 696732 3.2.1.114 0.075 - (2S,3R,4S)-2-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol extracted from endothelial cells HCEC 696732 3.2.1.114 0.075 - (2S,3R,4S)-2-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol extracted from human glioblastoma cells LNZ308 696732 3.2.1.114 0.075 - (3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidin-2-one extracted from endothelial cells HCEC 696732 3.2.1.114 0.075 - (3R,4R,5S)-5-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]-3,4-dihydroxy-1-methylpyrrolidin-2-one extracted from human glioblastoma cells LN18 696732 3.2.1.114 0.075 - (3R,4R,5S)-5-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]-3,4-dihydroxypyrrolidin-2-one extracted from endothelial cells HCEC 696732 3.2.1.114 0.15 - (3R,4R,5S)-5-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]-3,4-dihydroxypyrrolidin-2-one extracted from human glioblastoma cells LNZ308 696732 3.2.1.114 0.2 - (2S,3R,4S)-2-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol extracted from human glioblastoma cells LN18 696732 3.2.1.114 0.35 - (3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidin-2-one extracted from human glioblastoma cells LN18 696732 3.2.1.114 0.72 - (2R,3R,4S)-2-([[(1S)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol - 682766 3.2.1.114 0.75 - (3R,4R,5S)-5-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]-3,4-dihydroxypyrrolidin-2-one extracted from human glioblastoma cells LN18 696732 3.2.1.114 0.8 - (2R,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol - 682766 3.2.1.114 1 - (2R,3R,4S,5R)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-5-methylpyrrolidine-3,4-diol - 682766 3.2.1.114 1.5 - 2-phenylethyl alpha-D-mannopyranosyl sulfone in 50 mM sodium acetate buffer pH 5.8, at 37°C 714909 3.2.1.114 2 - benzyl alpha-D-mannopyranosyl sulfone in 50 mM sodium acetate buffer pH 5.8, at 37°C 714909 3.2.1.114 2 - di-epi-swainsonine - 682772 3.2.1.114 2.5 - (RS)-2-phenylethyl alpha-D-mannopyranosyl sulfoxide in 50 mM sodium acetate buffer pH 5.8, at 37°C 714909