1.1.1.153 0.00000149 - QM385 pH and temperature not specified in the publication 761589 1.1.1.153 0.000014 - sulfathiazole pH and temperature not specified in the publication 761589 1.1.1.153 0.000019 - sulfamethoxazole pH and temperature not specified in the publication 761589 1.1.1.153 0.0000235 - sulfasalazine pH and temperature not specified in the publication 761589 1.1.1.153 0.00003 - 2-(6-azaspiro[3.4]octane-6-sulfonyl)-3,5-difluorophenol at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.000031 - sulfasalazine pH 6.4, 37°C, sepiapterin reduction 740892 1.1.1.153 0.000031 - sulfasalazine pH not specified in the publication, temperature not specified in the publication 740892 1.1.1.153 0.00004 - 2-(6-azaspiro[3.4]octane-6-sulfonyl)-5-fluorophenol at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.000057 - (6-aza-spiro[3.4]oct-6-yl)-(2,4-difluoro-6-hydroxyphenyl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.000062 - sulfathiazole pH 6.4, 37°C, sepiapterin reduction 740892 1.1.1.153 0.000062 - sulfathiazole pH not specified in the publication, temperature not specified in the publication 740892 1.1.1.153 0.000074 - SPRi3 pH and temperature not specified in the publication 761589 1.1.1.153 0.000083 - 2-(6-azaspiro[3.4]octane-6-sulfonyl)-3,5-dichlorophenol at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00009 - Hg2+ IC50 0.00009 mM 286021 1.1.1.153 0.00012 - (2,4-dichloro-6-hydroxyphenyl)(2,3-dihydro-1H-indol-1-yl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00012 - Chlorpropamide pH 6.4, 37°C, sepiapterin reduction 740892 1.1.1.153 0.00012 - Chlorpropamide pH not specified in the publication, temperature not specified in the publication 740892 1.1.1.153 0.000141 - sulfapyridine pH 6.4, 37°C, sepiapterin reduction 740892 1.1.1.153 0.000141 - sulfapyridine pH not specified in the publication, temperature not specified in the publication 740892 1.1.1.153 0.00018 - sulfamethoxazole pH 6.4, 37°C, sepiapterin reduction 740892 1.1.1.153 0.00018 - sulfamethoxazole pH not specified in the publication, temperature not specified in the publication 740892 1.1.1.153 0.0002 - dicoumarol wild-type, pH 6.7, 37°C 725527 1.1.1.153 0.00021 - (2,4-dichloro-6-hydroxyphenyl)(3,4-dihydroisoquinolin-2(1H)-yl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00024 - (2,4-dichloro-6-hydroxyphenyl)(4-phenylpiperidin-1-yl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00028 - (3-anilinopyrrolidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00029 - (6-azaspiro[3.4]octan-6-yl)(2-fluoro-6-hydroxyphenyl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00029 - N-acetylsulfapyridine pH and temperature not specified in the publication 761589 1.1.1.153 0.00031 - (2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-3-yl)oxy]pyrrolidin-1-yl]methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00031 - (4-benzylpiperidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00031 - (6-azaspiro[3.4]octan-6-yl)(5-chloro-3-hydroxypyridin-2-yl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00034 - glibenclamide pH 6.4, 37°C, sepiapterin reduction 740892 1.1.1.153 0.00035 - (6-azaspiro[3.4]octan-6-yl)(5-fluoro-3-hydroxypyridin-2-yl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00037 - (2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-3-yl)pyrrolidin-1-yl]methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00037 - Chlorpropamide pH 6.4, 37°C, redox cycling 740892 1.1.1.153 0.00037 - mesalamine pH and temperature not specified in the publication 761589 1.1.1.153 0.00038 - (2,4-dichloro-6-hydroxyphenyl)[3-(2-phenylethyl)pyrrolidin-1-yl]methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00046 - (6-azaspiro[3.5]nonan-6-yl)(2,4-dichloro-6-hydroxyphenyl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00048 - sulfapyridine pH and temperature not specified in the publication 761589 1.1.1.153 0.00051 - Tolbutamide pH 6.4, 37°C, sepiapterin reduction 740892 1.1.1.153 0.00052 - (2,4-dichloro-6-hydroxyphenyl)(3-phenylpyrrolidin-1-yl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00053 - sulfasalazine pH 6.4, 37°C, redox cycling 740892 1.1.1.153 0.00055 - (2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-4-yl)methyl]pyrrolidin-1-yl]methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00058 - (6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-6-hydroxyphenyl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.0006 - (2,4-dichloro-6-hydroxyphenyl)[3-(1-methyl-1H-pyrazol-4-yl)pyrrolidin-1-yl]methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.0006 - dicoumarol IC50 0.0006 mM 286021 1.1.1.153 0.0006 - dicoumarol pH and temperature not specified in the publication 761589 1.1.1.153 0.0006 - N-acetylserotonin IC50 0.0006 mM 286021 1.1.1.153 0.0006 - N-acetylserotonin pH and temperature not specified in the publication 761589 1.1.1.153 0.0006 - [4-(benzenesulfonyl)piperidin-1-yl](2,4-dichloro-6-hydroxyphenyl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00061 - (2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-3-yl)methyl]pyrrolidin-1-yl]methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00061 - (6-azaspiro[3.4]octan-6-yl)(3-hydroxypyridin-2-yl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00062 - (2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-4-yl)pyrrolidin-1-yl]methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00067 - (6-azaspiro[3.4]octan-6-yl)(2-chloro-4-fluoro-6-hydroxyphenyl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00068 - (2,4-dichloro-6-hydroxyphenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00074 - (3-benzylpyrrolidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00079 - (2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-2-yl)pyrrolidin-1-yl]methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00098 - (5-azaspiro[2.4]heptan-5-yl)(2,4-dichloro-6-hydroxyphenyl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00111 - glibenclamide pH 6.4, 37°C, redox cycling 740892 1.1.1.153 0.00131 - (2,4-dichloro-6-hydroxyphenyl)[3-(trifluoromethyl)pyrrolidin-1-yl]methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00145 - (6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxyphenyl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00155 - (6-azaspiro[3.4]octan-6-yl)(5-hydroxypyrimidin-4-yl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00157 - (6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-3-fluoro-6-hydroxyphenyl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.0016 - phenylquinone wild-type, pH 6.7, 37°C 725527 1.1.1.153 0.00168 - (2,4-dichloro-6-hydroxyphenyl)(2-oxa-6-azaspiro[3.4]octan-6-yl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00199 - (2,4-dichloro-6-hydroxyphenyl)(pyrrolidin-1-yl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00232 - (6-azaspiro[3.4]octan-6-yl)[2-chloro-4-(dimethylamino)-6-hydroxyphenyl]methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.0024 - (2-azaspiro[4.4]nonan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00244 - (2,4-dichloro-6-hydroxyphenyl)(2-methyl-2,3-dihydro-1H-indol-1-yl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00256 - (2,4-dichloro-6-hydroxyphenyl)(1,3-dihydro-2H-isoindol-2-yl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.0026 - N-acetylserotonin wild-type, pH 6.7, 37°C 725527 1.1.1.153 0.0028 - benzoquinone wild-type, pH 6.7, 37°C 725527 1.1.1.153 0.0036 - 9,10-phenanthrenequinone wild-type, pH 6.7, 37°C 725527 1.1.1.153 0.00404 - (6-azaspiro[3.4]octan-6-yl)(4-chloro-2-hydroxyphenyl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.0045 - propionic acid IC50 0.0045 mM, pH 6.5 286013 1.1.1.153 0.00458 - Tolbutamide pH 6.4, 37°C, redox cycling 740892 1.1.1.153 0.00478 - (2-azaspiro[3.4]octan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.0051 - (2,4-dichloro-6-hydroxyphenyl)(3,3-dimethylpyrrolidin-1-yl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00527 - (2,4-dichloro-6-hydroxyphenyl)(3-fluoro-3-methylpyrrolidin-1-yl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00585 - (2-azaspiro[4.5]decan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.0065 - Isosepiapterin IC50 0.0065 mM, 0.05 mM: 83% inhibition 286013 1.1.1.153 0.00748 - (6-azaspiro[3.4]octan-6-yl)(2,3-dichloro-6-hydroxyphenyl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00772 - (6-azaspiro[3.4]octan-6-yl)(4-chloro-2-fluoro-6-hydroxyphenyl)methanone at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.00802 - sulfathiazole pH 6.4, 37°C, redox cycling 740892 1.1.1.153 0.0081 - indomethacin wild-type, pH 6.7, 37°C 725527 1.1.1.153 0.0089 - 1,2-naphthoquinone wild-type, pH 6.7, 37°C 725527 1.1.1.153 0.01 - (2,4-dichloro-6-hydroxyphenyl)(2-methyl-2,6-diazaspiro[3.4]octan-6-yl)methanone IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.01 - (6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-6-methoxyphenyl)methanone IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.01 - (6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxy-4-methoxyphenyl)methanone IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.01 - (6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxy-4-methylphenyl)methanone IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.01 - (6-azaspiro[3.4]octan-6-yl)(2-fluoro-6-hydroxy-4-methylphenyl)methanone IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.01 - (6-azaspiro[3.4]octan-6-yl)(2-hydroxypyridin-3-yl)methanone IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.01 - (6-azaspiro[3.4]octan-6-yl)(3,4-dichloro-2-hydroxyphenyl)methanone IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.01 - (6-azaspiro[3.4]octan-6-yl)(3,6-dichloro-2-hydroxyphenyl)methanone IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.01 - (6-azaspiro[3.4]octan-6-yl)(3-chloro-5-hydroxypyridin-4-yl)methanone IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.01 - (6-azaspiro[3.4]octan-6-yl)(3-hydroxypyridin-4-yl)methanone IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.01 - (6-azaspiro[3.4]octan-6-yl)(4,5-dichloro-2-hydroxyphenyl)methanone IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.01 - (6-azaspiro[3.4]octan-6-yl)(4-chloro-2-hydroxy-6-methylphenyl)methanone IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.01 - (6-azaspiro[3.4]octan-6-yl)(4-fluoro-2-hydroxyphenyl)methanone IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.01 - (6-azaspiro[3.4]octan-6-yl)(4-hydroxypyridin-3-yl)methanone IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.01 - (6-azaspiro[3.4]octan-6-yl)[2-chloro-6-hydroxy-4-(trifluoromethyl)phenyl]methanone IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.01 - 2-(6-azaspiro[3.4]octane-6-sulfonyl)-3-fluorophenol IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.01 - 4-(6-azaspiro[3.4]octane-6-carbonyl)-3-chloro-5-hydroxybenzamide IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.01 - 4-(6-azaspiro[3.4]octane-6-carbonyl)-3-chloro-5-hydroxybenzonitrile IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication 761681 1.1.1.153 0.01 - Cibacron Blue 3G-A IC50 0.01 mM 286015 1.1.1.153 0.011 - sulfamethoxazole pH 6.4, 37°C, redox cycling 740892 1.1.1.153 0.014 - 6-Carboxypterin IC50 0.014 mM, 0.05 mM: 77% inhibition 286013 1.1.1.153 0.0194 - sulfapyridine pH 6.4, 37°C, redox cycling 740892 1.1.1.153 0.03 - 6-Carboxypterin IC50 0.03 mM 286021 1.1.1.153 0.03 - 6-Carboxypterin pH and temperature not specified in the publication 761589 1.1.1.153 0.03 - Ethacrynic acid IC50 0.03 mM 286021 1.1.1.153 0.03 - Ethacrynic acid pH and temperature not specified in the publication 761589 1.1.1.153 0.032 - n-butyric acid IC50 0.032 mM, pH 6.5 286013 1.1.1.153 0.032 - n-butyric acid pH and temperature not specified in the publication 761589 1.1.1.153 0.045 - propionic acid pH and temperature not specified in the publication 761589 1.1.1.153 0.06 - indomethacin IC50 0.06 mM 286021 1.1.1.153 0.06 - indomethacin pH and temperature not specified in the publication 761589 1.1.1.153 0.06 - rutin IC50 0.06 mM 286021 1.1.1.153 0.06 - rutin pH and temperature not specified in the publication 761589 1.1.1.153 0.065 - Isosepiapterin pH and temperature not specified in the publication 761589 1.1.1.153 0.1 - Cd2+ IC50 0.1 mM 286021 1.1.1.153 0.1 - Melatonin recombinant enzyme, in 100 mM potassium phosphate buffer (pH 6.4), at 37°C 698883 1.1.1.153 0.2 - N-acetylserotonin recombinant enzyme, in 100 mM potassium phosphate buffer (pH 6.4), at 37°C 698883 1.1.1.153 0.25 - n-valeric acid IC50 0.25 mM, pH 6.5 286013 1.1.1.153 0.3 - propionic acid IC50 0.3 mM, pH 6.4 286021 1.1.1.153 0.4 - Zn2+ IC50 0.4 mM 286021 1.1.1.153 0.45 - acetic acid IC50 0.45 mM, pH 6.5 286013 1.1.1.153 0.45 - acetic acid pH and temperature not specified in the publication 761589 1.1.1.153 0.6 - Phenobarbital slight, IC50 0.6 mM 286021 1.1.1.153 1 - pyrazole slight, IC50 1 mM 286021 1.1.1.153 5 - alpha-ketoglutarate slight, IC50 5 mM 286021