3.5.3.18 A 2.18 A resolution X-ray crystal structure of the inactivated complex elucidates the orientation of the inactivator and its covalent attachment to the active site Cys 719651 3.5.3.18 by sitting drop vapor diffusion, at 1.08-2.0 A resolution and at pH 6.3 and pH 9.0 670913 3.5.3.18 N5-(1-iminopropyl)-L-ornithine:DDAH-1 complex, to 1.9 A resolution, covalent bond formation between the inhibitor’s amidino carbon and the active-site Cys274, and solution studies show reversible competitive inhibition, consistent with a reversible covalent mode of DDAH inhibition by alkylamidine inhibitors 711211