3.4.21.27 full-length zymogen FXI, and the isolated active protease domain of activated factor IX in complex with natural and synthetic inhibitors. Intimate linkage of the apple domains into a disk-like platform around the base of the catalytic domain 707856 3.4.21.27 hanging drop method 693547 3.4.21.27 hanging drop vapor diffusion 669392, 669420 3.4.21.27 hanging drop vapour diffusion 667059 3.4.21.27 in complaex with inhibitors, hanging drop vapor diffusion method, using 0.2 M (NH4)2SO4, 25% (w/v) polyethylene glycol methyl ether 2000, and 100 mM NaOAc, pH 4.6 732318 3.4.21.27 in complex with inhibitors, hanging drop vapor diffusion method, using 0.1 M citrate pH 4.7-5.2, 20-26% (w/v) PEG 4K 731076 3.4.21.27 purified recombinant catalytic domain of mutant S434A/T475A/C482S/K437A complexed with benzylamidine, crystallization solution is 2.0 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.5, overnight at 10 °C, cryoprotection by 20% v/v glycerol, X-ray diffraction structure determination and anaylsis at 2.25 A resolution 683756