3.4.21.B10 - 3.4.21.B10 crystal structures of the APPIWT/KLK6 and APPI-4M/KLK6 complexes reveal the structural and mechanistic bases for the improved KLK6 binding and proteolytic resistance of APPI-4M. APPI is the amyloid precursor protein Kunitz protease inhibitor domain. APPI-4M i.e. APPI(M17L/I18F/S19F/F34V) 3.4.21.B10 purified enzyme bound to inhibitor 9b, X-ray diffraction structure determination and analysis at 1.68 A resolution