2.4.1.50	sitting drop vapor diffusion method, crystal structures of full-length human LH3 in complex with cofactors and donor substrates provide a molecular understanding of the biochemical knowledge underlying the multiple functions of this enzyme	
2.4.1.50	structures of full-length human LH3 in complex with cofactors and donor substrates. LH3 has three domains encompassing multiple catalytic sites and forms elongated tail-to-tail dimers showing two distinct catalytic sites at the N- and C-terminal boundaries of each monomer. The glycosyltransferase domain displays distinguishing features compared to other known glycosyltransferases. Known disease-related mutations map in close proximity to the catalytic sites