3.5.4.4 additional information - additional information the adenine moiety of inhibitors does not bind to the histidine residues of the active site His238 654788 3.5.4.4 0.00007 - erythro-9-(2-hydroxy-3-nonyl)-adenine pH 7.1, 23°C, after preincubation with diethyl dicarbonate 654788 3.5.4.4 0.00008 - erythro-9-(2-hydroxy-3-nonyl)-adenine pH 7.1, 23°C 654788 3.5.4.4 0.00009 - diethyl dicarbonate pH 7.1, 23°C, in presence of 0.022 mM erythro-9-(2-hydroxy-3-nonyl)-adenine 654788 3.5.4.4 0.00011 - erythro-9-(2-hydroxy-3-nonyl)-3-deazaadenine pH 7.1, 23°C, after preincubation with diethyl dicarbonate 654788 3.5.4.4 0.00013 - diethyl dicarbonate pH 7.1, 23°C, in presence of 0.03 mM erythro-9-(2-hydroxy-3-nonyl)-3-deazaadenine 654788 3.5.4.4 0.00014 - erythro-9-(2-hydroxy-3-nonyl)-3-deazaadenine pH 7.1, 23°C 654788 3.5.4.4 0.007 - 1-deazaadenosine pH 7.1, 23°C 654788 3.5.4.4 0.0074 - 1-deazaadenosine pH 7.1, 23°C, after preincubation with diethyl dicarbonate 654788 3.5.4.4 0.01 - diethyl dicarbonate pH 7.1, 23°C, in presence of 0.008 mM 1-deazaadenosine 654788 3.5.4.4 0.016 - purine riboside pH 7.5, 25°C 655734 3.5.4.4 0.126 - acetaminophen pH 7.5, 27°C 656388 3.5.4.4 0.214 - acetaminophen pH 7.5, 37°C 656388 3.5.4.4 0.012 - 7,8-dihydro-1-p-methoxybenzyl-6H-6,7-dimethyl-8-propoxyimidazo[4,5-e][1,2,4]-triazepine pH 7.0, 25°C 656467 3.5.4.4 0.015 - 8-butoxy-7,8-dihydro-1-p-methoxybenzyl-6H-6,7-dimethylimidazo[4,5-e][1,2,4]triazepine pH 7.0, 25°C 656467 3.5.4.4 0.02 - 7,8-dihydro-8-ethoxy-1-p-methoxybenzyl-6H-6,7-dimethylimidazo[4,5-e][1,2,4]triazepine pH 7.0, 25°C 656467 3.5.4.4 0.023 - 7,8-dihydro-1-p-methoxybenzyl-8-(2-methoxyethoxy)-6H-6,7-dimethylimidazo[4,5-e][1,2,4]triazepine pH 7.0, 25°C 656467 3.5.4.4 0.024 - 7,8-dihydro-8-methoxy-1-p-methoxybenzyl-6H-6,7-dimethylimidazo[4,5-e][1,2,4]triazepine pH 7.0, 25°C 656467 3.5.4.4 0.03 - 7,8-dihydro-8-isopropoxy-1-p-methoxybenzyl-6H-6,7-dimethylimidazo[4,5-e][1,2,4]triazepine pH 7.0, 25°C 656467 3.5.4.4 0.077 - 7,8-dihydro-1-p-methoxybenzyl-8-(4-methoxybenzyloxy)-6H-6,7-dimethylimidazo[4,5-e][1,2,4]triazepine pH 7.0, 25°C 656467 3.5.4.4 0.093 - 7,8-dihydro-1-p-methoxybenzyl-8-(3-methylbenzyloxy)-6H-6,7-dimethylimidazo[4,5-e][1,2,4]triazepine pH 7.0, 25°C 656467 3.5.4.4 additional information - additional information inhibition kinetics of the large and the small isozyme 667032 3.5.4.4 additional information - additional information inhibition kinetics of the large isozyme 667032 3.5.4.4 0.000021 - erythro-9-(2-hydroxy-3-nonyl)adenine kidney cortex large isozyme 667032 3.5.4.4 0.000025 - 3-deaza-erythro-9-(2-hydroxy-3-nonyl)adenine blood serum large isozyme 667032 3.5.4.4 0.00003 - erythro-9-(2-hydroxy-3-nonyl)adenine pleural fluid large isozyme 667032 3.5.4.4 0.000036 - 3-deaza-erythro-9-(2-hydroxy-3-nonyl)adenine pleural fluid large isozyme 667032 3.5.4.4 0.00004 - erythro-9-(2-hydroxy-3-nonyl)adenine lung small isozyme 667032 3.5.4.4 0.00005 - 3-deaza-erythro-9-(2-hydroxy-3-nonyl)adenine kidney cortex large isozyme 667032 3.5.4.4 0.000057 - erythro-9-(2-hydroxy-3-nonyl)adenine spleen small isozyme 667032 3.5.4.4 0.00006 - erythro-9-(2-hydroxy-3-nonyl)adenine blood serum large isozyme 667032 3.5.4.4 0.00011 - 3-deaza-erythro-9-(2-hydroxy-3-nonyl)adenine spleen small isozyme 667032 3.5.4.4 0.00012 - 3-deaza-erythro-9-(2-hydroxy-3-nonyl)adenine lung small isozyme 667032 3.5.4.4 0.0004 - 1-deaza-erythro-9-(2-hydroxy-3-nonyl)adenine kidney cortex large isozyme 667032 3.5.4.4 0.00045 - 1-deaza-erythro-9-(2-hydroxy-3-nonyl)adenine pleural fluid large isozyme 667032 3.5.4.4 0.0006 - 1-deaza-erythro-9-(2-hydroxy-3-nonyl)adenine blood serum large isozyme 667032 3.5.4.4 0.0011 - 1-deaza-erythro-9-(2-hydroxy-3-nonyl)adenine spleen small isozyme 667032 3.5.4.4 0.0012 - 1-deaza-erythro-9-(2-hydroxy-3-nonyl)adenine lung small isozyme 667032 3.5.4.4 0.0016 - 1-deazaadenosine kidney cortex large isozyme 667032 3.5.4.4 0.0025 - 1-deazaadenosine pleural fluid large isozyme 667032 3.5.4.4 0.0029 - 1-deazaadenosine blood serum large isozyme 667032 3.5.4.4 0.0029 - 1-deazaadenosine lung small isozyme 667032 3.5.4.4 0.0057 - 1-deazaadenosine spleen small isozyme 667032 3.5.4.4 0.52 - 3-deazaadenosine blood serum large isozyme 667032 3.5.4.4 0.69 - 3-deazaadenosine kidney cortex large isozyme 667032 3.5.4.4 0.81 - 3-deazaadenosine lung small isozyme 667032 3.5.4.4 1 - 3-deazaadenosine above, pleural fluid large isozyme 667032 3.5.4.4 1 - 3-deazaadenosine above, spleen small isozyme 667032 3.5.4.4 0.0000049 - 1-[(R)-4-(5-(3-(4-chlorophenyl)propoxyl)-1-methylindol-3-yl)-1-hydroxy-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.0000075 - 1-[(R)-4-(6-(3-benzylureido)indol-1-yl)-1-hydroxy-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.0000077 - 1-[(R)-1-hydroxy-4-(6-(5-phenylvalerylamino)indol-1-yl)-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.000011 - 1-[(R)-1-hydroxy-4-(6-(3-(1-methylbenzimidazol-2-yl)propionylamino)indol-1-yl)-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.000012 - 1-[(R)-1-hydroxy-4-(6-(4-phenylbutoxy)indol-1-yl)-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.000013 - 1-[(R)-4-(5-hexyloxy-1-methylindol-3-yl)-1-hydroxy-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.000013 - 1-[(R)-4-(6-(3-(4-chlorophenyl)propoxy)indol-1-yl)-1-hydroxy-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.000016 - 1-[(R)-1-hydroxy-4-(6-(4-phenylbutyrylamino)indol-1-yl)-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.000017 - 1-[(R)-1-hydroxy-4-(6-(3-(3-pyridyl)propionylamino)indol-1-yl)-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.000017 - 1-[(R)-1-hydroxy-4-(6-(3-phenylpropoxy)indol-1-yl)-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.000024 - 1-[(R)-4-(6-hexanoylaminoindol-1-yl)-1-hydroxy-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.000026 - 1-[(R)-1-hydroxy-4-(1-methyl-5-(3-phenylpropoxy)indol-3-yl)-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.00003 - 1-[(R)-1-hydroxy-4-(6-(3-phenylpropionylamino)indol-1-yl)-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.000034 - 1-[(R)-1-hydroxy-4-(6-(4-(4-methylphenyl)butyrylamino)indol-1-yl)-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.000038 - 1-[(R)-1-hydroxy-4-(6-(3-(4-methylphenyl)propionylamino)indol-1-yl)-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.000055 - 1-[(R)-4-(6-hexyloxyindol-1-yl)-1-hydroxy-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.000057 - 1-[(R)-1-hydroxy-4-(6-(3-(4-methoxyphenyl)propionylamino)indol-1-yl)-1-hydroxy-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.000091 - 1-[(R)-1-hydroxy-4-(6-(6-phenylhexanoylamino)indol-1-yl)-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.00024 - 1-[(R)-4-(6-butoxyindol-1-yl)-1-hydroxy-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.0013 - 1-[(R)-4-(6-acetylaminoindol-1-yl)-1-hydroxy-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.0019 - 1-[(R)-1-hydroxy-4-(5-(3-phenylpropoxy)indol-1-yl)-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.0062 - 1-[(R)-4-(5-hexyloxyindol-1-yl)-1-hydroxy-2-butyl]imidazole-4-carboxamide - 669771 3.5.4.4 0.00000114 - erythro-9-(2-hydroxy-3-nonyl)adenine pH 7.2, 30°C 669783 3.5.4.4 0.000066 - 4-amino-1-(2-hydroxy-3-nonyl)pyrazolo[3,4d]pyrimidine pH 7.2, 30°C 669783 3.5.4.4 0.00462 - 4-amino-1-(beta-hydroxyethyl)pyrazolo[3,4d]pyrimidine pH 7.2, 30°C 669783 3.5.4.4 0.00000043 - 5'-methylthiocoformycin - 687290 3.5.4.4 0.00000079 - 5'-methylthio-2'-deoxycoformycin - 687290 3.5.4.4 additional information - additional information kinetics and thermodynamic effects of inhibitors, QSAR analysis, overview 688029 3.5.4.4 0.03 - diclofenac pH 7.5, 37°C 688029 3.5.4.4 0.0428 - Acetylsalicylic acid pH 7.5, 27°C 688029 3.5.4.4 0.0564 - diclofenac pH 7.5, 27°C 688029 3.5.4.4 0.0968 - Acetylsalicylic acid pH 7.5, 37°C 688029 3.5.4.4 additional information - additional information inhibition kinetics 688040 3.5.4.4 0.17 - adenine pH 7.5, 25°C 688040 3.5.4.4 0.25 - phenylhydrazine pH 7.5, 25°C 688040 3.5.4.4 0.33 - 2-Aminopurine pH 7.5, 25°C 688040 3.5.4.4 0.35 - Inosine pH 7.5, 25°C 688040 3.5.4.4 1.1 - purine pH 7.5, 25°C 688040 3.5.4.4 1.3 - 4-aminopyrimidine pH 7.5, 25°C 688040 3.5.4.4 1.4 - 4-hydroxypyridine pH 7.5, 25°C 688040 3.5.4.4 1.8 - 4-aminopyridine pH 7.5, 25°C 688040 3.5.4.4 0.0106 - 4-amino-1-(beta-D-ribofuranosyl)-3H-imidazo[4,5-d]pyridazin-7-(6H)-one pH 7.4, 25°C 688295 3.5.4.4 0.0121 - 2'-deoxy-4-amino-1-(beta-D-ribofuranosyl)-3H-imidazo[4,5-d]pyridazin-7-(6H)-one pH 7.4, 25°C 688295 3.5.4.4 0.0265 - 5-carbamimidoyl-1-(beta-D-ribofuranosyl)-1H-imidazole-4-carbohydrazide pH 7.4, 25°C 688295 3.5.4.4 0.0514 - 7-amino-1-(beta-D-ribofuranosyl)-1H-imidazo[4,5-d]pyridazin-4-(5H)-one pH 7.4, 25°C 688295 3.5.4.4 0.052 - 2'-deoxy-7-amino-1-(beta-D-ribofuranosyl)-1H-imidazo[4,5-d]pyridazin-4-(5H)-one pH 7.4, 25°C 688295 3.5.4.4 0.000077 - 1-[(1R)-1-(hydroxymethyl)-3-(6-[[(1-methyl-1H-benzimidazol-2-yl)acetyl]amino]-1H-indol-1-yl)propyl]-1H-imidazole-4-carboxamide - 699144 3.5.4.4 0.00011 - 1-[(1R,2S)-2-hydroxy-1-(2-naphthalen-1-ylethyl)propyl]-1H-imidazole-4-carboxamide - 699144 3.5.4.4 0.00024 - 1-[(1R)-3-[6-(hexanoylamino)-1H-indol-1-yl]-1-(hydroxymethyl)propyl]-1H-imidazole-4-carboxamide - 699144 3.5.4.4 0.0068 - 1-[(1R)-1-(hydroxymethyl)-3-naphthalen-1-ylpropyl]-1H-imidazole-4-carboxamide - 699144 3.5.4.4 0.013 - 1-[(1R)-3-[6-(acetylamino)-1H-indol-1-yl]-1-(hydroxymethyl)propyl]-1H-imidazole-4-carboxamide - 699144 3.5.4.4 0.059 - 1-[(1R)-1-(hydroxymethyl)-3-phenylpropyl]-1H-imidazole-4-carboxamide - 699144 3.5.4.4 0.54 - 1-[(1R)-2-hydroxy-1-phenylethyl]-1H-imidazole-4-carboxamide - 699144 3.5.4.4 0.0000016 - 1-[4-[(4-oxo-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)methyl]phenyl]-3-[4-(trifluoromethyl)phenyl]urea 30°C, pH 7.10 699455 3.5.4.4 0.0000096 - 4-fluoro-N-[4-[(4-oxo-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)methyl]phenyl]benzamide 30°C, pH 7.4 699455 3.5.4.4 0.0000114 - erythro-9-(2-hydroxy-3-nonyl)adenine 30°C, pH 7.15 699455 3.5.4.4 0.0000115 - 1-(4-fluorophenyl)-3-[4-[(4-oxo-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)methyl]phenyl]urea 30°C, pH 7.9 699455 3.5.4.4 0.0000201 - 1-[4-(dimethylamino)phenyl]-3-[4-[(4-oxo-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)methyl]phenyl]urea 30°C, pH 7.11 699455 3.5.4.4 0.0000242 - 1-[4-[(4-oxo-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)methyl]phenyl]-3-phenylurea 30°C, pH 7.7 699455 3.5.4.4 0.000051 - N-[4-[(4-oxo-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)methyl]phenyl]-4-(trifluoromethyl)benzamide 30°C, pH 7.5 699455 3.5.4.4 0.0001265 - N-[4-[(4-oxo-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)methyl]phenyl]benzamide 30°C, pH 7.2 699455 3.5.4.4 0.0001556 - 4-methoxy-N-[4-[(4-oxo-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)methyl]phenyl]benzamide 30°C, pH 7.3 699455 3.5.4.4 0.0002827 - 1-(4-methoxyphenyl)-3-[4-[(4-oxo-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)methyl]phenyl]urea 30°C, pH 7.8 699455 3.5.4.4 0.000478 - N-[4-[(4-oxo-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)methyl]phenyl]-2-phenylacetamide 30°C, pH 7.6 699455 3.5.4.4 0.000857 - 1-benzyl-3-[4-[(4-oxo-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)methyl]phenyl]urea 30°C, pH 7.14 699455 3.5.4.4 0.00108 - 1-[4-[(4-oxo-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)methyl]phenyl]-3-(4-phenoxyphenyl)urea 30°C, pH 7.13 699455 3.5.4.4 0.00186 - 1-(4-benzylphenyl)-3-[4-[(4-oxo-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)methyl]phenyl]urea 30°C, pH 7.12 699455 3.5.4.4 0.008 - purine riboside 25°C, 50 mM Tris-HCl buffer, pH 7.4, enzyme concentration 1.5 nM 699651 3.5.4.4 0.018 - N6-methyladenosine 25°C, 50 mM Tris-HCl buffer, pH 7.4, enzyme concentration 1.5 nM 699651 3.5.4.4 0.0000015 - D-coformycin mutant enzyme D172E, in 100 mM Tris-HCl buffer (pH 8.0), temperature not specified in the publication 711215 3.5.4.4 0.0000018 - D-coformycin mutant enzyme D172A, in 100 mM Tris-HCl buffer (pH 8.0), temperature not specified in the publication 711215 3.5.4.4 0.0000023 - D-coformycin wild type enzyme, in 100 mM Tris-HCl buffer (pH 8.0), temperature not specified in the publication 711215 3.5.4.4 0.0000032 - 5'-methylthiocoformycin wild type enzyme, in 100 mM Tris-HCl buffer (pH 8.0), temperature not specified in the publication 711215 3.5.4.4 0.0000034 - D-coformycin wild type enzyme, in 100 mM Tris-HCl buffer (pH 8.0), temperature not specified in the publication 711215 3.5.4.4 0.0000047 - D-coformycin wild type enzyme, in 100 mM Tris-HCl buffer (pH 8.0), temperature not specified in the publication 711215 3.5.4.4 0.000007 - D-coformycin wild type enzyme, in 100 mM Tris-HCl buffer (pH 8.0), temperature not specified in the publication 711215 3.5.4.4 0.0000074 - D-coformycin wild type enzyme, in 100 mM Tris-HCl buffer (pH 8.0), temperature not specified in the publication 711215 3.5.4.4 0.000014 - 5'-methylthiocoformycin wild type enzyme, in 100 mM Tris-HCl buffer (pH 8.0), temperature not specified in the publication 711215 3.5.4.4 0.000014 - D-coformycin wild type enzyme, in 100 mM Tris-HCl buffer (pH 8.0), temperature not specified in the publication 711215 3.5.4.4 0.00002 - 5'-methylthiocoformycin wild type enzyme, in 100 mM Tris-HCl buffer (pH 8.0), temperature not specified in the publication 711215 3.5.4.4 0.00003 - 5'-methylthiocoformycin wild type enzyme, in 100 mM Tris-HCl buffer (pH 8.0), temperature not specified in the publication 711215 3.5.4.4 0.000048 - 5'-methylthiocoformycin wild type enzyme, in 100 mM Tris-HCl buffer (pH 8.0), temperature not specified in the publication 711215 3.5.4.4 0.029 - 5'-methylthiocoformycin wild type enzyme, in 100 mM Tris-HCl buffer (pH 8.0), temperature not specified in the publication 711215 3.5.4.4 0.0009 - (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol mutant D172A, pH 7.5, 30°C 718893 3.5.4.4 0.0019 - (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol wild-type, pH 7.5, 30°C 718893 3.5.4.4 0.0005 - erythro-9-(2-hydroxy-3-nonyl)adenine pH 7.4, 37°C 719423 3.5.4.4 0.00000025 - coformycin 37°C, pH not specified in the publication 720969 3.5.4.4 0.0000034 - 2'-deoxycoformycin 37°C, pH not specified in the publication 720969 3.5.4.4 0.00000011 - (2S,3R)-3-(6-amino-9H-purin-9-yl)-5-[3-(trifluoromethyl)phenyl]pentan-2-ol pH 7.0, temperature not specified in the publication 752963 3.5.4.4 0.0000022 - (+)-erythro-9-(2-hydroxy-3-nonyl)adenine pH 7.0, temperature not specified in the publication 752963 3.5.4.4 0.0000052 - (2S,3R)-3-(6-amino-9H-purin-9-yl)-5-[4-(trifluoromethyl)phenyl]pentan-2-ol pH 7.0, temperature not specified in the publication 752963 3.5.4.4 0.0000059 - 1-[(3R,4S)-4-hydroxy-1-[3-(trifluoromethyl)phenyl]pentan-3-yl]-1H-imidazole-4-carboxamide pH 7.0, temperature not specified in the publication 752963