5.1.3.7 NAD+ - 662221, 716865, 726860, 746866, 747460 5.1.3.7 NAD+ enzyme-bound, exogenous NAD+ does not appear to be a strong activator of enzyme activity, there is no significant difference in enzyme activity regardless of the presence and absence of NAD+ 746915 5.1.3.7 NAD+ highly stimulated by small amounts, Km: 0.13 mM 2411 5.1.3.7 NAD+ most potent activator 2414 5.1.3.7 NAD+ required 2416 5.1.3.7 NAD+ the N-terminal domain harbors the conserved sequence GxxGxxG forming a modified Rossmann-fold involved in binding of the cofactor NAD+ 747049 5.1.3.7 NAD+ tight binding to protein during its synthesis 652005 5.1.3.7 NADH - 716865, 726860 5.1.3.7 NADH stimulates to a lesser gegree than NAD+ 2414 5.1.3.7 NADH tight binding to protein during its synthesis 652005