2.7.12.2 ATP - 490796, 662926, 665990, 666399, 679153, 682214, 682326, 686711, 687739, 688931, 705260, 705707, 739844, 740258, 740278, 740416, 740419, 740483, 740497, 740693, 740701, 740705, 740713, 740818, 740925, 741009, 741027, 741140, 741156, 741160 2.7.12.2 ATP dependent on 490935 2.7.12.2 ATP subdomain II with an invariable lysine residue is responsible for ATP binding 666395 2.7.12.2 ATP upon ATP-binding, the transient conformation adopted the configuration of typical kinase folding. In the absence of ATP-binding, the transient state of apo npMAP2K4 may shift to a state of aggregation via non-particular hydrophobic interactions as a result of the exposed hydrophobic residues 739980