2.1.1.170 S-adenosyl-L-methionine - 721042 2.1.1.170 S-adenosyl-L-methionine S-adenosyl-L-methionine is bound in a canonical conformation above the beta-sheet and close to the conserved GxGxG methyltransferase signature motif (residues 88–92 between strand beta1 and helix alpha4). The AdoMet cofactor is tightly bound in RsmG and copurifies with the recombinant protein 706725