1.1.1.267 additional information cofactor docking study with DXR, presence of conserved NADPH-binding motif (GSTGSIGT and LAAGSNV) in N-terminal end of the CaDXR protein sequence 762525 1.1.1.267 NAD(P)H - 699265 1.1.1.267 NAD+ - 654748, 673562 1.1.1.267 NADH - 654748 1.1.1.267 NADH 14% of the activity with NADPH 673562 1.1.1.267 NADH 15% of the activity with NADPH 676660 1.1.1.267 NADP+ - 286420, 286421, 286422, 286423, 286424, 286425, 286426, 286427, 286428, 654748, 655439, 672040, 673562, 674260, 697870, 748373, 760333, 762525, 762667, 762747, 762782, 762794, 762871, 763000, 763120, 763181, 763279, 763482, 763547, 763576, 763591, 763607 1.1.1.267 NADPH - 654748, 654877, 654973, 655439, 671075, 671590, 672040, 672396, 672538, 673073, 673562, 674260, 675577, 676579, 676736, 684210, 691382, 697249, 697335, 697870, 723812, 724346, 724374, 724543, 725564, 725663, 748373, 760333, 762525, 762667, 762747, 762782, 762794, 762871, 763000, 763120, 763181, 763279, 763482, 763547, 763576, 763591, 763607 1.1.1.267 NADPH dependent on 698490 1.1.1.267 NADPH has a highly conserved binding site for NADPH 700838