2.7.11.22 ATP - 489976, 490796, 490797, 490800, 660948, 662124, 662152, 662686, 662688, 662855, 662926, 663933, 664005, 664030, 664160, 664179, 664332, 664536, 664955, 665053, 665056, 665488, 665497, 665645, 665840, 665862, 665968, 665977, 665980, 665982, 666109, 666117, 666120, 666124, 666184, 666185, 666186, 666340, 666347, 666401, 666466, 666467, 666468, 666575, 666588, 666624, 666635, 666718, 666728, 666744, 678926, 690991, 691554, 695013, 707369, 707637, 707843, 707917, 707985, 707997, 708041, 708631, 708648, 708842, 709335, 709585, 709637, 721248, 721817, 721962, 721986, 722194, 722706, 722744, 723022, 723073, 723176, 723178, 723423, 723513, 723656, 723745 2.7.11.22 ATP ATP binding pocket structure, the pocket is a cleft located at the interface between two domains, involvd residues, overview 664689 2.7.11.22 ATP binding at the active site between the C- and N-terminal enzyme domains 666862 2.7.11.22 ATP dependent on 490935 2.7.11.22 ATP mutant Cdk1-as1 has an enlarged ATP binding site 666440 2.7.11.22 ATP the binding site is a deep pocket lined by hydrophobic residues, enzyme affinity of cdk2 for ATP is not influenced by phosphorylation of the activation loop 490931 2.7.11.22 cyclin - 680759, 681873, 690991, 691272, 691554, 691679, 691982, 691988, 693022, 693721, 693746, 693747, 693758, 693762, 693903, 694081, 694150, 694187, 694491, 695204, 707369, 707637, 707843, 707997, 708041, 708631, 708648, 708842, 709335, 709510, 709585 2.7.11.22 cyclin active CDK-cyclin oscillates during the cell cycle 664332 2.7.11.22 cyclin dependent on 693779 2.7.11.22 cyclin dependent on as regulatory subunit 663933 2.7.11.22 cyclin regulatory subunit of CDK 664536 2.7.11.22 cyclin regulatory subunit of the CDK 666728 2.7.11.22 cyclin A - 666862, 691801 2.7.11.22 cyclin A cofactor of CDK2 694510, 707917 2.7.11.22 cyclin A competes with cyclin E isoforms 665497 2.7.11.22 cyclin A complexes with CDKA 666635 2.7.11.22 cyclin A cyclin A–cyclin-dependent enzyme. Phosphorylation of elongation factor 2 on Ser595 by the cyclin A-dependent enzyme directly stimulates phosphorylation of elongation factor 2 by elongation factor 2 kinase on Thr56 723178 2.7.11.22 cyclin A full activation of CDK2 requires both binding of cyclin A or cyclin E and phosphorylation of residue T160 in the activation segment (also known as the T-loop) by the CDK-activating kinase 695013 2.7.11.22 cyclin A in complex with CDK2 691302 2.7.11.22 cyclin A is required as regulatory subunit of CDK2 in cell cycle S, M, and G1 phases 665840 2.7.11.22 cyclin A regulatory subunit of Cdk2 665977, 665980, 666347 2.7.11.22 cyclin A required regulatory subunit of CDKs 666109 2.7.11.22 cyclin B - 691256, 692997 2.7.11.22 cyclin B cofactor of CDK1 707917 2.7.11.22 cyclin B complexes with CDKA and CDKB 666635 2.7.11.22 cyclin B interacts with and activates Cdc2/Cdk1 666467 2.7.11.22 cyclin B is required as regulatory subunit of CDK2 in cell cycle G2 and M phases 665840 2.7.11.22 cyclin B regulatory subunit cyclin B and catalytic subunit Cdk1, HCMV-infection leads to accumulation of active cyclin B in cells due to increased synthesis and reduced degradation 666185 2.7.11.22 cyclin B regulatory subunit of CDK1 665980, 665982, 666468 2.7.11.22 cyclin B regulatory subunit of CDKA,1 666624 2.7.11.22 cyclin B stabilizing regulatory subunit of Cdk1 665053 2.7.11.22 cyclin B1 required regulatory subunit of CDKs 666109 2.7.11.22 cyclin B2 i.e. Clb2 666440 2.7.11.22 cyclin B5 i.e. Clb5, specificity mechanism, overview 666440 2.7.11.22 cyclin C cofactor of CDK3 707917 2.7.11.22 cyclin Clb5 - 680023 2.7.11.22 cyclin Clb6 - 680023 2.7.11.22 cyclin D - 682384 2.7.11.22 cyclin D cofactor of CDK4 and CDK6 707917 2.7.11.22 cyclin D in complex with CDK4 691302 2.7.11.22 cyclin D is required as regulatory subunit of CDK4 665840 2.7.11.22 cyclin D required regulatory subunit of CDKs 666109 2.7.11.22 cyclin D1 cofactor of CDK4 707985 2.7.11.22 cyclin D1 regulatory subunit of Cdk2 665977 2.7.11.22 cyclin D1 regulatory subunit of CDK6, activates 666744 2.7.11.22 cyclin D1 regulatory subunit of CDKs, SwissProt-ID Q8GVE0 665862 2.7.11.22 cyclin D2 expression analysis in response to Cdk-Activity and phytohormone levels, e.g. of cytokinin and abscisic acid, cytokinin stimulates sucrose-dependently the expression of cyclin D2 at the late germination state of the embryo 666588 2.7.11.22 cyclin D2 regulatory subunit of the holoenzyme formed with CDK4 664005 2.7.11.22 cyclin D2 regulatory subunit, dependent on 664030 2.7.11.22 cyclin D2 required regulatory subunit of cdk6 666109 2.7.11.22 cyclin D3 cofactor of CDK11 707917 2.7.11.22 cyclin D3 PFTK1 specifically interacted with cyclin D3 682579 2.7.11.22 cyclin D3 regulatory subunit of CDKs, SwissProt-ID Q8GVD9 665862 2.7.11.22 cyclin E - 691105, 691293, 691430, 693698, 695048 2.7.11.22 cyclin E cofactor of CDK2 707917, 707985, 709637 2.7.11.22 cyclin E dependent on, high expression level in breast cancer cells, activating low molecular weight forms L, T1, and T2 of the cyclin E are expressed in breast cancer, modeling of CDK2 activation by cyclin E, overview 665497 2.7.11.22 cyclin E full activation of CDK2 requires both binding of cyclin A or cyclin E and phosphorylation of residue T160 in the activation segment (also known as the T-loop) by the CDK-activating kinase 695013 2.7.11.22 cyclin E in complex with CDK2 691302 2.7.11.22 cyclin E interacts with and activates Cdk2 666467 2.7.11.22 cyclin E is required as regulatory subunit of CDK2 in cell cycle G1 phase 665840 2.7.11.22 cyclin E regulatory subunit of Cdk2 665977 2.7.11.22 cyclin E required regulatory subunit of CDKs 666109 2.7.11.22 cyclin E stabilizing regulatory subunit of Cdk2 665053 2.7.11.22 cyclin E2 cofactor of CDK3 707917 2.7.11.22 cyclin H cofactor of CDK7 707917, 707985 2.7.11.22 cyclin H dependent on, regulatory subunit 666705 2.7.11.22 cyclin H interacts with CDKF,1, dependent on, CDK activity requires specific cyclin partners 666575 2.7.11.22 cyclin K - 695232 2.7.11.22 cyclin L cofactor of CDK11 707917 2.7.11.22 cyclin Pcl1 - 694216 2.7.11.22 cyclin Pcl10 - 694216 2.7.11.22 cyclin Pcl2 - 694216 2.7.11.22 cyclin Pcl3 - 694216 2.7.11.22 cyclin Pcl4 - 694216 2.7.11.22 cyclin Pcl5 - 694216 2.7.11.22 cyclin Pcl6 - 694216 2.7.11.22 cyclin Pcl7 - 694216 2.7.11.22 cyclin Pcl8 - 694216 2.7.11.22 cyclin Pcl9 - 694216 2.7.11.22 cyclin Pho80 - 694216 2.7.11.22 cyclin T - 694675, 695232 2.7.11.22 cyclin T CDKC1 and CDKC2 form P-TEFb-like complexes with cyclin T14 and cyclin T15 694625 2.7.11.22 cyclin T cofactor of CDK9 707985 2.7.11.22 cyclin V regulatory subunit of CDK6 665982 2.7.11.22 cyclin-1 regulatory subunit 665968 2.7.11.22 additional information determination of cyclin specificity of Cdk1 during cell cycle and with different enzyme substrates, overview 666440 2.7.11.22 additional information Pho85 associates with 10 Pho85 cyclins 694216 2.7.11.22 additional information viral K-cyclin has a much longer half-life compared to cellular cyclins because it lacks the PEST degradation sequence, the viral K-cyclin can substitute the cellular cyclins in binding to the cellular CDKs, which is important for the virus development 666109