2.7.11.18 ATP - 490797, 490801, 660857, 660858, 661436, 661664, 661665, 661729, 661920, 662275, 662503, 662504, 663442, 663446, 671753, 672981, 672984, 673994, 674829, 675010, 675068, 675541, 675623, 675729, 675888, 676189, 677138, 684333, 684356, 684910, 685933, 686119, 687732, 687922, 688218, 688628, 688705, 689353, 707035, 707084, 708142, 708823, 708840, 709148, 709225, 709236, 709287, 709602, 709692, 709713, 709732, 709733, 709858, 710379, 740026, 740060, 740131, 740266, 740289, 740727, 740793, 740823, 740887, 741247 2.7.11.18 ATP ATP-binding motif X-Gly-X-Gly-X-XGly-X 684910 2.7.11.18 ATP residues A27, A29, A32, and A31 are involved in binding 662502 2.7.11.18 Calmodulin - 640652, 640655, 640659, 640660, 660858, 661664, 662502, 662503, 662504, 663446, 708823, 709148, 709692, 710379 2.7.11.18 Calmodulin 1:1 stoichiometric complex in the presence of Ca2+ 640635, 640645 2.7.11.18 Calmodulin aged enzyme loses Ca2+/calmodulin sensitivity by proteolysis 640619 2.7.11.18 Calmodulin binding site I at residue 1002-1022, binding site II at residues 26-42, complex formation with Ca2+ 660857 2.7.11.18 Calmodulin calmodulin in presence of Ca2+ abolishes the inhibition of actin-myosin interaction 640648, 640649, 640650 2.7.11.18 Calmodulin dependent on 661665, 661729, 708142, 709858 2.7.11.18 Calmodulin lower affinity for Ca2+/caldesmon after phosphorylation by cAMP-dependent protein kinase, Ka: 0.0000006 mM 640627 2.7.11.18 Calmodulin not 491266 2.7.11.18 Calmodulin only active as ternary complex of calmodulin, Ca2+ and kinase: activation is initiated by binding of Ca2+ to calmodulin 640621 2.7.11.18 Calmodulin optimal ratio of enzyme to calmodulin for telokin phosphorylation is 1:4 640651 2.7.11.18 Calmodulin requirement 491268, 640615, 640618, 640619, 640620, 640621, 640622, 640623, 640624, 640625, 640626, 640627, 640628, 640629, 640630, 640631, 640632, 640633, 640634, 640635, 640637, 640638, 640639, 640640, 640641, 640642, 640643, 640644, 640645 2.7.11.18 Calmodulin trypsin or chymotrypsin digested smooth muscle enzyme is independent of Ca2+/calmodulin 640632, 640634, 640635, 640645