1.21.1.1 FAD - 704369 1.21.1.1 Ferredoxin - 733237 1.21.1.1 flavin a flavin mononucleotide-dependent deiodinase 733459 1.21.1.1 flavin dependent on 733360 1.21.1.1 flavin presence of a neutral flavin radical during the reaction. Radical is stable and persists at 4°C under aerobic conditions for many days 704182 1.21.1.1 FMN - 726449, 733452, 744171, 744363, 746394 1.21.1.1 FMN 1 mol of FMN per mol of protein 704368 1.21.1.1 FMN dependent on 733237 1.21.1.1 FMN enzyme is reduced in two successive 1-electron oxidation-reduction steps. The oxidation-reduction potential of the couple semiquinone/fully reduced enzyme is -0.412 V at pH 7 and 25°C. The value for the oxidized/semiquinone couple is -0.190 V at pH 7 and 25°C 704369 1.21.1.1 FMN FMN binds non-covalently at the dimer interface established by a helix from each of the two identical subunits involving residues Ser102 and Ser128. Iodotyrosine deiodinase utilizes FMN to maintain iodide homeostasis by reductive deiodination of iodotyrosine. In the absence of an active site ligand, only the oxidized and two-electron-reduced forms of FMN are detected 734321 1.21.1.1 FMN the FMN-binding site of mammalian IYD is conserved in SUP-18, FMN appears to require catalytic activity to function 734996 1.21.1.1 FMNH2 - 726449 1.21.1.1 additional information the cofactors form a redox electron transport chain, overview 733237 1.21.1.1 NADH - 734996 1.21.1.1 NADP+ - 744171, 744363, 746394 1.21.1.1 NADPH - 733360, 733452 1.21.1.1 NADPH dependent on 733459 1.21.1.1 NADPH NADPH is a necessary donor of electrons for the reductive reaction 733237