6.3.2.61 6.8 8.9 the enzyme activity increases markedly with the pH going from 6.8 to 8.3, with a large optimum between 8.3 and 8.9, and then decreases sharply. At physiological pH, the activity is 15% of the maximal level 749873 6.3.2.61 7.5 9.2 pH 7.5: about 45% of maximal activity, pH 9.2: about 80% of maximal activity. When the glutamate concentration is raised to 6 mM, the activity is less dependent on pH, decreasing by only 40% between pH 8.7 and 6.8 749873