2.1.1.6 additional information - wild-type is independent of pH 755786 2.1.1.6 6.8 8.4 leads to maximal formation of 2-methoxyestradiol-17beta 441523 2.1.1.6 7 - membrane-bound enzyme 657525 2.1.1.6 7 8 methylation of 2-hydroxyestradiol or 4-hydroxyestradiol by MB-COMT 686075 2.1.1.6 7 8 methylation of 2-hydroxyestradiol or 4-hydroxyestradiol by S-COMT 686075 2.1.1.6 7.1 7.4 - 441513 2.1.1.6 7.3 8.2 - 441509 2.1.1.6 7.4 - membrane-bound activity 657526 2.1.1.6 7.5 - - 441551 2.1.1.6 7.5 8.2 - 441507 2.1.1.6 7.6 7.8 - 441526 2.1.1.6 7.8 - - 441533 2.1.1.6 7.8 - soluble activity 657526 2.1.1.6 7.8 - soluble enzyme 657525 2.1.1.6 8 - - 441535 2.1.1.6 8 8.5 - 441515 2.1.1.6 9.2 - leads to maximal formation of 2- and 3-monomethyl ether 441523