4.2.3.63	(2E,6E)-farnesyl diphosphate	-	Streptomyces sp.	(+)-cubenene + diphosphate	reaction proceeds via 1,3-hydride shift. (3R)-nerolidyl diphosphate is an intermediate in the cyclization. Cyclization of [ 13,13,13-2H3]farnesy1 diphosphate with crude epicubenol synthase gives [ 13,13,13-2H3]epicubenol	?	413130	
4.2.3.63	(2E,6E)-farnesyl diphosphate	specific substrate	Streptomyces sp.	(+)-cubenene + diphosphate	-	?	413130	
4.2.3.63	(2E,6E)-farnesyl diphosphate	specific substrate	Streptomyces sp.	(+)-cubenene + diphosphate	reaction proceeds via 1,2- and 1,3-hydride shifts. (3R)-nerolidyl diphosphate is an intermediate in the cyclization. The initial isomerization of farnesyl diphosphate to (3R)-nerolidyl diphosphate takes place with suprafacial stereochemistry. Ionization of (3R)-nerolidyl diphosphate and attack by the 10-11 double bond on the re face of the cisoid allylic cation-diphosphate anion pair generates the cis-germacradienyl cation. A second electrophilic cyclization gives the cadinanyl cation, which upon a 1.2-hydride shift and syn capture of water generates epicubenol	?	413130	
4.2.3.63	(2E,6E)-farnesyl diphosphate	specific substrae	Heteroscyphus planus	(+)-cubenene + diphosphate	(+)-cubenene synthase and (+)-epicubenol synthase are dual functions of the same enzyme	?	413130	
4.2.3.63	(2E,6E)-farnesyl diphosphate	specific substrae	Heteroscyphus planus	(+)-cubenene + diphosphate	reaction proceeds via 1,2- and 1,3-hydride shifts	?	413130	
4.2.3.63	(2E,6E)-farnesyl diphosphate	-	Streptomyces sp. LL-B7	(+)-cubenene + diphosphate	reaction proceeds via 1,3-hydride shift. (3R)-nerolidyl diphosphate is an intermediate in the cyclization. Cyclization of [ 13,13,13-2H3]farnesy1 diphosphate with crude epicubenol synthase gives [ 13,13,13-2H3]epicubenol	?	413130	
4.2.3.63	(2E,6E)-farnesyl diphosphate	specific substrate	Streptomyces sp. LL-B7	(+)-cubenene + diphosphate	-	?	413130	
4.2.3.63	(2E,6E)-farnesyl diphosphate	specific substrate	Streptomyces sp. LL-B7	(+)-cubenene + diphosphate	reaction proceeds via 1,2- and 1,3-hydride shifts. (3R)-nerolidyl diphosphate is an intermediate in the cyclization. The initial isomerization of farnesyl diphosphate to (3R)-nerolidyl diphosphate takes place with suprafacial stereochemistry. Ionization of (3R)-nerolidyl diphosphate and attack by the 10-11 double bond on the re face of the cisoid allylic cation-diphosphate anion pair generates the cis-germacradienyl cation. A second electrophilic cyclization gives the cadinanyl cation, which upon a 1.2-hydride shift and syn capture of water generates epicubenol	?	413130	
4.2.3.63	(2E,6E)-farnesyl diphosphate + H2O	specific substrate	Streptomyces sp.	(+)-epicubenol + diphosphate	reaction proceeds via 1,2- and 1,3-hydride shifts. (3R)-nerolidyl diphosphate is an intermediate in the cyclization. The initial isomerization of farnesyl diphosphate to (3R)-nerolidyl diphosphate takes place with suprafacial stereochemistry. Ionization of (3R)-nerolidyl diphosphate and attack by the 10-11 double bond on the re face of the cisoid allylic cation-diphosphate anion pair generates the cis-germacradienyl cation. A second electrophilic cyclization gives the cadinanyl cation, which upon a 1.2-hydride shift and syn capture of water generates epicubenol	?	413131	
4.2.3.63	(2E,6E)-farnesyl diphosphate + H2O	specific substrate	Streptomyces sp. LL-B7	(+)-epicubenol + diphosphate	reaction proceeds via 1,2- and 1,3-hydride shifts. (3R)-nerolidyl diphosphate is an intermediate in the cyclization. The initial isomerization of farnesyl diphosphate to (3R)-nerolidyl diphosphate takes place with suprafacial stereochemistry. Ionization of (3R)-nerolidyl diphosphate and attack by the 10-11 double bond on the re face of the cisoid allylic cation-diphosphate anion pair generates the cis-germacradienyl cation. A second electrophilic cyclization gives the cadinanyl cation, which upon a 1.2-hydride shift and syn capture of water generates epicubenol	?	413131