1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase estrogenic estrone + NAD(P)H + H+ the product 17beta-estradiol plays a central role in the etiology of estrogen dependent diseases Homo sapiens 17beta-estradiol + NAD(P)+ 458625 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase estrone + NAD(P)H + H+ - Homo sapiens 17beta-estradiol + NAD(P)+ 424802 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase estrone + NADPH estrogen activation Homo sapiens estradiol + NADP+ 386463 1.1.1.62 17beta-estradiol 17-dehydrogenase 1,2-dimethyl-6-dehydroestrone + NADH - Homo sapiens 1,2-dimethyl-6-dehydroestradiol + NAD+ 188466 1.1.1.62 17beta-estradiol 17-dehydrogenase 1,2-dimethylestrone + NADH - Homo sapiens 1,2-dimethylestradiol + NAD+ 188465 1.1.1.62 17beta-estradiol 17-dehydrogenase 1-methyl-6-dehydroestrone + NADH - Homo sapiens 1-methyl-6-dehydroestradiol + NAD+ 188463 1.1.1.62 17beta-estradiol 17-dehydrogenase 16-ketoestrone + NADH - Homo sapiens 16-ketoestradiol + NAD+ 188483 1.1.1.62 17beta-estradiol 17-dehydrogenase 18-nor-D-homoestrone 3-methyl ether + NADH - Homo sapiens 18-nor-D-homoestradiol 3-methyl ether + NAD+ 188484 1.1.1.62 17beta-estradiol 17-dehydrogenase 2,4-dinitroestrone + NADH - Homo sapiens 2,4-dinitroestradiol + NAD+ 188459 1.1.1.62 17beta-estradiol 17-dehydrogenase 2,4-dinitroestrone 3-oxyacetic acid ether + NADH - Homo sapiens 2,4-dinitroestradiol 3-oxyacetic acid ether + NAD+ 188460 1.1.1.62 17beta-estradiol 17-dehydrogenase 2-methoxyestrone + NADH - Homo sapiens 2-methoxyestradiol + NAD+ 188453 1.1.1.62 17beta-estradiol 17-dehydrogenase 2-nitroestrone + NADH - Homo sapiens 2-nitroestradiol + NAD+ 188450 1.1.1.62 17beta-estradiol 17-dehydrogenase 2-nitroestrone 3-oxyacetic acid ester + NADH + H+ - Homo sapiens 2-nitroestradiol-17beta-3-oxyacetic acid ester + NAD+ 188451 1.1.1.62 17beta-estradiol 17-dehydrogenase 4-aminoestrone + NADH - Homo sapiens 4-aminoestradiol + NAD+ 188456 1.1.1.62 17beta-estradiol 17-dehydrogenase 4-aminoestrone 3,4-diacetate + NADH - Homo sapiens 4-aminoestradiol 3,4-diacetate + NAD+ 188457 1.1.1.62 17beta-estradiol 17-dehydrogenase 4-nitrestrone + NADH - Homo sapiens 4-nitroestradiol + NAD+ 188455 1.1.1.62 17beta-estradiol 17-dehydrogenase 6-dehydroestrone 3-benzoate + NADH - Homo sapiens 6-dehydro-17beta-estradiol 3-benzoate + NAD+ 188443 1.1.1.62 17beta-estradiol 17-dehydrogenase 6-ketoestrone + NADH - Homo sapiens 6-ketoestradiol-17beta + NAD+ 188473 1.1.1.62 17beta-estradiol 17-dehydrogenase 6alpha,7alpha-dihydroxyestrone + NADH - Homo sapiens 6alpha,7alpha-dihydroxyestradiol + NAD+ 188479 1.1.1.62 17beta-estradiol 17-dehydrogenase 7-ketoestrone + NADH - Homo sapiens 7-ketoestradiol-17beta + NAD+ 188474 1.1.1.62 17beta-estradiol 17-dehydrogenase 7alpha-hydroxyestrone + NADH - Homo sapiens 7alpha-hydroxyestradiol + NAD+ 188476 1.1.1.62 17beta-estradiol 17-dehydrogenase 7beta-hydroxyestrone + NADH - Homo sapiens 7beta-hydroxyestradiol + NAD+ 188475 1.1.1.62 17beta-estradiol 17-dehydrogenase estrogenic estrone + NAD(P)H + H+ the product 17beta-estradiol plays a central role in the etiology of estrogen dependent diseases Homo sapiens 17beta-estradiol + NAD(P)+ 458625 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NAD(P)H - Homo sapiens estradiol-17beta + NAD(P)+ 370948 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NAD(P)H final step in the synthesis of active estrogens Homo sapiens estradiol-17beta + NAD(P)+ 370948 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NAD(P)H the enzyme produces active estradiol for cell proliferation Homo sapiens estradiol-17beta + NAD(P)+ 370948 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NAD(P)H - Homo sapiens estradiol + NAD(P)+ 375121 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NAD(P)H normal and tubal pregancies possess identical expression of 17HSD1 in syncytiotrophoblast cells and therefore, similar estradiol production in the placenta. Association of 17HSD1 with extravillous cells indicates that the enzyme perhaps plays a role in trophoblast invasion.Increased expression of 17HSD1 in epithelial cells of fallopian tube may lead to a local estradiol supply sufficient for maintenance of tubal pregnancy Homo sapiens estradiol + NAD(P)+ 375121 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NAD(P)H + H+ - Homo sapiens estradiol + NAD(P)+ 383143 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NAD(P)H + H+ 17beta-hydroxysteroid dehydrogenase has a pivotal role in regulating the synthesis of estradiol within breast tumours. 17beta-hydroxysteroid dehydrogenase activity contributes to the high estradiol concentrations found in most breast tumours Homo sapiens estradiol + NAD(P)+ 383143 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NAD(P)H + H+ the enzyme efficiently converts estrone to estradiol and enhances the estrogen-dependent growth of cultured MCF-7 cells in the presence of hormonally less active estrone. The reaction is reversible in vitro, but in cultured cells the production of estradiol is the predominant rection in physiological conditions Homo sapiens estradiol + NAD(P)+ 383143 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NAD(P)H + H+ type 12 17beta-hydroxysteroid dehydrogenase plays a role in estrogen formation. Type 12 17beta-hydroxysteroid dehydrogenase is the major estrogenic 17beta-HSD responsible for the conversion of estrone to estradiol in women, especially in the ovary, the predominant source of estrogens before menopause Homo sapiens estradiol + NAD(P)+ 383143 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NAD(P)H + H+ - Homo sapiens estradiol-17beta + NAD(P)+ 383144 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NAD(P)H + H+ type 1 17beta-hydroxysteroid dehydrogenase plays a critical role in the biosynthesis of estradiol Homo sapiens estradiol-17beta + NAD(P)+ 383144 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NAD(P)H + H+ 7beta-HSD type 1 Homo sapiens estradiol-17beta + NAD(P)+ 383144 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NAD(P)H + H+ - Homo sapiens 17beta-estradiol + NAD(P)+ 424802 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADH - Homo sapiens estradiol-17beta + NAD+ 188425 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADH key enzyme responsible for elevated levels of 17beta-estradiol in breast tumor tissues Homo sapiens estradiol-17beta + NAD+ 188425 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADH exposure to epidermal growth factor slowly induces a cellular state in which enzyme activity is subject to modulation by both progesterone and estradiol Homo sapiens estradiol-17beta + NAD+ 188425 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADH 17beta-estradiol is a potent stimulator of certain endocrine-dependent forms of breast cancer. The enzyme catalyzes the last step in the biosynthesis of 17beta-estradiol from the less potent estrogen, estrone Homo sapiens estradiol-17beta + NAD+ 188425 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADH type 1 enzyme, catalyzes the conversion of the low activity estrogen, estrone, into highly active estradiol, both in the gonads and in target tissues Homo sapiens estradiol-17beta + NAD+ 188425 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADH the reductive activity predominates in hormone dependent breast tumors. This gives rise to high concentrations of estradiol in breast cancer Homo sapiens estradiol-17beta + NAD+ 188425 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADH trans-retinoic acid increases expression of the enzyme in a dose-dependent and time-dependent manner in T47D breast cancer cells, the increased expression is associated with an increase in reductive activity of the enzyme Homo sapiens estradiol-17beta + NAD+ 188425 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADH + H+ - Homo sapiens estradiol-17beta + NAD+ 384667 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADH + H+ 17beta-HSD1 Homo sapiens estradiol-17beta + NAD+ 384667 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADH + H+ - Homo sapiens estradiol + NAD+ 397125 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADH + H+ - Homo sapiens 17beta-estradiol + NAD+ 438332 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH - Homo sapiens 17beta-estradiol + NADP+ 386462 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH convertion of the weak androgen estrone into the potent estrogen 17beta-estradiol Homo sapiens 17beta-estradiol + NADP+ 386462 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH isozyme 17beta-HSD1 Homo sapiens 17beta-estradiol + NADP+ 386462 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH the reversible reaction constitutes an important pre-receptor control mechanism for nuclear receptor ligands, since the conversion switches between the 17beta-hydroxy receptor ligands and their inactive 17-oxo metabolites Homo sapiens 17beta-estradiol + NADP+ 386462 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH substrate of e.g. isozyme 17beta-HSD3, 17beta-HSD8, and 17beta-HSD14 Homo sapiens 17beta-estradiol + NADP+ 386462 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH - Homo sapiens estradiol + NADP+ + H+ 414597 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH + H+ - Homo sapiens estradiol-17beta + NADP+ 188427 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH + H+ type 1 enzyme is a cytosolic isoform highly specific for estradiol. Type 2 is a membrane bound isoform reactive with both estradiol and testosterone Homo sapiens estradiol-17beta + NADP+ 188427 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH + H+ 17beta-HSD1, final step in the synthesis of active estrogens Homo sapiens estradiol-17beta + NADP+ 188427 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH + H+ final step in the synthesis of active estrogens Homo sapiens estradiol-17beta + NADP+ 188427 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH + H+ final step in the synthesis of active estrogens, maintenance of a proper balance of inactive estrone and active estradiol-17beta in brain Homo sapiens estradiol-17beta + NADP+ 188427 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH + H+ reverse reaction catalyzed by different isoforms of the enzyme Homo sapiens estradiol-17beta + NADP+ 188427 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH + H+ final step in synthesis of estradiol Homo sapiens estradiol-17beta + NADP+ 188427 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH + H+ - Homo sapiens estradiol + NADP+ 397126 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH + H+ kinetics demonstrates positive cooperativity Homo sapiens estradiol + NADP+ 397126 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH + H+ - Homo sapiens estradiol-17beta + NADP 405081 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH + H+ - Homo sapiens 17beta-estradiol + NADP+ 414596 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH + H+ most active enzyme in regards to 17beta-estradiol production Homo sapiens 17beta-estradiol + NADP+ 414596 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH + H+ the enzyme show positive cooperativity Homo sapiens 17beta-estradiol + NADP+ 414596 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH + H+ - Homo sapiens 17beta-estradiol + NAD(P)+ 458627 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone + NADPH + H+ steroid hormone pathway Homo sapiens 17beta-estradiol + NAD(P)+ 458627 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone 3-methyl ether + NADH - Homo sapiens 3-O-methyl-17beta-estradiol + NAD+ 188441 1.1.1.62 17beta-estradiol 17-dehydrogenase estrone 3-oxyacetic acid ether + NADH - Homo sapiens 17beta-estradiol 3-O-oxyacetic acid ether + NAD+ 188442 1.1.1.62 17beta-estradiol 17-dehydrogenase estronesulfate + NADPH - Homo sapiens 17beta-estradiolsulfate + NADP+ 386464 1.1.1.71 alcohol dehydrogenase [NAD(P)+] estrone + NADPH + H+ - Homo sapiens ? 439513 1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) estrone + NADPH + H+ - Homo sapiens 17beta-estradiol + NADP+ 414596 1.1.1.300 NADP-retinol dehydrogenase estrone + NADH + H+ no substrate for wild-type, but substrate for mutant M144G Homo sapiens estradiol + NAD+ 397125 1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase estrone + NAD(P)H + H+ - Homo sapiens 17beta-estradiol + NAD(P)+ 424802 1.10.5.1 ribosyldihydronicotinamide dehydrogenase (quinone) estrone-3,4-quinone + N-benzyldihydronicotinamide ping-pong mechanism, NQO2 is faster in reducing estrogen quinones than its homologue NQO1 Homo sapiens estrone-3,4-quinol + N-benzylnicotinamide 405082 2.4.1.17 glucuronosyltransferase 2-hydroxyestrone + UDP-glucuronate - Homo sapiens ? 387157 2.4.1.17 glucuronosyltransferase 2-hydroxyestrone + UDPglucuronate - Homo sapiens 2-hydroxyestrone 2-O-glucuronide + UDP 322209 2.4.1.17 glucuronosyltransferase 2-hydroxyestrone + UDPglucuronate glucuronidated by UGT1A3 and HGT1A9 Homo sapiens 2-hydroxyestrone 2-O-glucuronide + UDP 322209 2.4.1.17 glucuronosyltransferase 4-hydroxyestrone + UDP-glucuronate - Homo sapiens UDP + 4-hydroxyestrone 4-O-glucuronide 322220 2.4.1.17 glucuronosyltransferase 4-hydroxyestrone + UDP-glucuronate - Homo sapiens UDP + 4-hydroxyestrone-4-O-beta-D-glucuronide 378078 2.4.1.17 glucuronosyltransferase 4-hydroxyestrone + UDP-glucuronate - Homo sapiens ? 387471 2.4.1.17 glucuronosyltransferase estrone + UDP-glucuronate - Homo sapiens UDP + estrone 3-O-glucuronide 452052 2.4.1.17 glucuronosyltransferase estrone + UDPglucuronate inactive Homo sapiens UDP + estrone 3-O-glucuronide 322194 2.4.1.17 glucuronosyltransferase estrone + UDPglucuronate glucuronidated by UGT1A3 and HGT1A9 Homo sapiens UDP + estrone 3-O-glucuronide 322194 2.4.1.17 glucuronosyltransferase UDP-D-glucuronate + 2-hydroxyestrone isozyme UGT1A1 Homo sapiens UDP + 2-hydroxyestrone beta-D-glucuronoside 402112 2.4.1.17 glucuronosyltransferase UDP-D-glucuronate + 4-hydroxy-estrone - Homo sapiens UDP + ? 402116 2.4.1.17 glucuronosyltransferase UDP-glucuronate + 2-hydroxyestrone - Homo sapiens UDP + 2-hydroxyestrone beta-D-glucuronide 378070 2.4.1.17 glucuronosyltransferase UDP-glucuronate + 2-methoxyestrone - Homo sapiens UDP + 2-methoxyestrone beta-D-glucuronide 378071 2.4.1.17 glucuronosyltransferase UDP-glucuronate + 4-hydroxy-estrone glucuronidation of 4-hydroxylated estrone is significantly reduced in breast carcinomas compared to healthy Homo sapiens UDP + ? 399105 2.4.1.17 glucuronosyltransferase UDP-glucuronate + 4-methoxyestrone - Homo sapiens UDP + 4-methoxyestrone beta-D-glucuronide 378079 2.4.1.17 glucuronosyltransferase UDP-glucuronate + estrone - Homo sapiens UDP + estrone beta-D-glucuronide 378119 2.4.1.17 glucuronosyltransferase UDP-glucuronate + estrone - Homo sapiens UDP + estrone beta-D-glucuronoside 436028 2.8.2.2 alcohol sulfotransferase 3'-phosphoadenylylsulfate + estrone - Homo sapiens adenosine 3',5'-bisphosphate + estrone sulfate 360214 2.8.2.4 estrone sulfotransferase 3'-phosphoadenylyl sulfate + estrone - Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate 386070 2.8.2.4 estrone sulfotransferase 3'-phosphoadenylyl sulfate + estrone SULT1E1 is involved in estrogen inactivation Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate 386070 2.8.2.4 estrone sulfotransferase 3'-phosphoadenylyl sulfate + estrone high activity by SULT1E1, low activity by phenol sulfotransferase SULT1A1, EC 2.8.2.1 Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate 386070 2.8.2.4 estrone sulfotransferase 3'-phosphoadenylyl sulfate + estrone estrone sulfate is biologically inactive, the conversion of estradiol to its sulfate prevents it from binding to and thereby activating the estrogen receptor Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate 386070 2.8.2.4 estrone sulfotransferase 3'-phosphoadenylyl sulfate + estrone hSULT1E1 catalyzes the sulfation of estrogens and regulates estrogen bioactivities Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate 386070 2.8.2.4 estrone sulfotransferase 3'-phosphoadenylyl sulfate + estrone the active site of hSULT1E1 contains Cys residues. Cys83 is critical for the redox regulation of hSULT1E1 Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate 386070