1.1.1.35 3-hydroxyacyl-CoA dehydrogenase 17beta-estradiol + NAD+ - Homo sapiens estrone + NADH + H+ 188057 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase 17beta-estradiol + NAD+ enzyme from brain contains 17beta-hydroxysteroid and 3alpha-hydroxysteroid dehydrogenase activity Homo sapiens estrone + NADH + H+ 188057 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase 17beta-estradiol + NAD+ enzyme conatains 17beta-hydroxysteroid and 3alpha-hydroxysteroid dehydrogenase activity Homo sapiens estrone + NADH + H+ 188057 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase 17beta-estradiol + NAD+ inactivation Homo sapiens estrone + NADH + H+ 188057 1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) 17beta-estradiol + NADP+ - Homo sapiens estrone + NADPH 188515 1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) estradiol + NAD(P)H - Homo sapiens estrone + NAD(P)+ 257221 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase estradiol + NAD(P)+ - Homo sapiens estrone + NAD(P)H 376765 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase estradiol + NAD+ - Homo sapiens estrone + NADH 188498 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase estradiol + NADP+ - Homo sapiens estrone + NADPH 188302 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase estradiol + NADP+ the equilibrium state is 3% estradiol and 97% estrone Homo sapiens estrone + NADPH 188302 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase estradiol sulfate + NADP+ - Homo sapiens estrone sulfate + NADPH 188303 1.1.1.62 17beta-estradiol 17-dehydrogenase 1,2-dimethylestradiol + NAD+ - Homo sapiens 1,2-dimethylestrone + NADH 188464 1.1.1.62 17beta-estradiol 17-dehydrogenase 1-methyl-6-dehydroestradiol + NAD+ - Homo sapiens 1-methyl-6-dehydroestrone + NADH 188462 1.1.1.62 17beta-estradiol 17-dehydrogenase 1-methylestradiol + NAD+ - Homo sapiens 1-methylestrone + NADH 188461 1.1.1.62 17beta-estradiol 17-dehydrogenase 11alpha-hydroxyestradiol + NAD+ - Homo sapiens 11alpha-hydroxyestrone + NADH 188480 1.1.1.62 17beta-estradiol 17-dehydrogenase 11beta-hydroxyestradiol + NAD+ - Homo sapiens 11beta-hydroxyestrone + NADH 188481 1.1.1.62 17beta-estradiol 17-dehydrogenase 17beta-estradiol + NAD(P)+ - Homo sapiens estrone + NAD(P)H + H+ 438065 1.1.1.62 17beta-estradiol 17-dehydrogenase 17beta-estradiol + NAD+ - Homo sapiens estrone + NADH + H+ 188057 1.1.1.62 17beta-estradiol 17-dehydrogenase 17beta-estradiol + NADP+ - Homo sapiens estrone + NADPH 188515 1.1.1.62 17beta-estradiol 17-dehydrogenase 17beta-estradiol + NADP+ isozyme 17beta-HSD4 Homo sapiens estrone + NADPH 188515 1.1.1.62 17beta-estradiol 17-dehydrogenase 17beta-estradiol + NADP+ - Homo sapiens estrone + NADPH + H+ 438066 1.1.1.62 17beta-estradiol 17-dehydrogenase 2,4-dinitroestradiol + NAD+ - Homo sapiens 2,4-dinitroestrone + NADH 188458 1.1.1.62 17beta-estradiol 17-dehydrogenase 2-aminoestradiol + NAD+ - Homo sapiens 2-aminoestrone + NADH 188452 1.1.1.62 17beta-estradiol 17-dehydrogenase 2-methylestradiol + NAD+ - Homo sapiens 2-methylestrone + NADH 188448 1.1.1.62 17beta-estradiol 17-dehydrogenase 2-nitroestradiol + NAD+ - Homo sapiens 2-nitroestrone + NADH 188449 1.1.1.62 17beta-estradiol 17-dehydrogenase 3-methyl-O-estradiol + NAD(P)+ - Homo sapiens 3-methyl-O-estrone + NAD(P)H 375816 1.1.1.62 17beta-estradiol 17-dehydrogenase 3-O-methyl-17beta-estradiol + NAD+ - Homo sapiens 3-O-methylestrone + NADH 188437 1.1.1.62 17beta-estradiol 17-dehydrogenase 4-nitroestradiol + NAD+ - Homo sapiens 4-nitroestrone + NADH 188454 1.1.1.62 17beta-estradiol 17-dehydrogenase 6alpha-hydroxyestradiol + NAD+ - Homo sapiens 6alpha-hydroxyestrone + NADH 188478 1.1.1.62 17beta-estradiol 17-dehydrogenase 7alpha-hydroxyestradiol + NAD+ - Homo sapiens 7alpha-hydroxyestrone + NADH 188477 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol + NAD(P)+ - Homo sapiens estrone + NAD(P)H 376765 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol + NAD+ - Homo sapiens estrone + NADH + H+ 414594 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol + NADP+ the equilibrium state is 92% estradiol to 8% estrone Homo sapiens estrone + NADPH 188302 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol + NADP+ - Homo sapiens estrone + NADPH + H+ 414595 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol-17beta + NAD(P)+ - Homo sapiens estrone + NAD(P)H 370947 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol-17beta + NAD(P)+ 17beta-HSD2 and 5, key role in regulating steroid receptor occupancy in normal and tumor tissues Homo sapiens estrone + NAD(P)H 370947 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol-17beta + NAD(P)+ - Homo sapiens estrone + NAD(P)H + H+ 383141 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol-17beta + NAD(P)+ 17beta-HSD4 is involved in etsrogen inactivation and may protect against an excessive accumulation of E2 in human ovarian epithelial cells Homo sapiens estrone + NAD(P)H + H+ 383141 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol-17beta + NAD(P)+ 7beta-HSD type 2 Homo sapiens estrone + NAD(P)H + H+ 383141 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol-17beta + NAD+ - Homo sapiens estrone + NADH 188424 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol-17beta + NAD+ type 1 enzyme is a cytosolic isoform highly specific for estradiol. Type 2 is a membrane bound isoform reactive with both estradiol and testosterone Homo sapiens estrone + NADH 188424 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol-17beta + NAD+ - Homo sapiens estrone + NADH + H+ 383142 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol-17beta + NAD+ vitamin K2 binds 17beta-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism. Vitamin K2 decreases the estradiol-17beta/estrone ratio in cells by 25% Homo sapiens estrone + NADH + H+ 383142 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol-17beta + NAD+ 17beta-HSD2 Homo sapiens estrone + NADH + H+ 383142 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol-17beta + NAD+ enzyme catalyzes the reduction of estrone to estradiol, the rate is 2.3% of the activity with estradiol Homo sapiens estrone + NADH + H+ 383142 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol-17beta + NADP+ - Homo sapiens estrone + NADPH 188426 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol-17beta + NADP+ maximal activity with NADP+ is approximately 1/3 of that with NAD+ Homo sapiens estrone + NADPH 188426 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol-17beta + NADP+ 17beta-HSD2, important role in peripheral inactivation of androgens and estrogens, 17beta-HSD4, low substrate affinity Homo sapiens estrone + NADPH 188426 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol-17beta + NADP+ reverse reaction catalyzed by different isoforms of the enzyme Homo sapiens estrone + NADPH 188426 1.1.1.62 17beta-estradiol 17-dehydrogenase estradiol-17beta + NADP+ - Homo sapiens estrone + NADPH + H+ 384666 1.1.1.64 testosterone 17beta-dehydrogenase (NADP+) 17beta-estradiol + NADP+ - Homo sapiens estrone + NADPH 188515 1.1.1.147 16alpha-hydroxysteroid dehydrogenase 17beta-estradiol-16-one + NAD(P)H - Homo sapiens 16alpha-hydroxy-17beta-estradiol + NAD(P)+ 187262 1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) estradiol + NAD+ - Homo sapiens estrone + NADH 188498 1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase 17beta-estradiol + NAD(P)H + H+ - Homo sapiens estrone + NAD(P)+ 424453 1.6.2.2 cytochrome-b5 reductase 2-hydroxyestradiol + O2 + NADH + H+ - Homo sapiens ? 461976 1.10.5.1 ribosyldihydronicotinamide dehydrogenase (quinone) 1-benzyl-1,4-dihydronicotinamide + estradiol-3,4-quinone - Homo sapiens 1-benzyl-3-carbamoylpyridinium + estrone-3,4-quinone 451183 2.1.1.6 catechol O-methyltransferase 2-hydroxyestradiol + S-adenosyl-L-methionine - Homo sapiens S-adenosyl-L-homocysteine + ? 395551 2.1.1.6 catechol O-methyltransferase 2-hydroxyestradiol + S-adenosyl-L-methionine MB-COMT methylates both 2-hydroxyestradiol and 4-hydroxyestradiol at comparable rates Homo sapiens S-adenosyl-L-homocysteine + ? 395551 2.1.1.6 catechol O-methyltransferase 2-hydroxyestradiol + S-adenosyl-L-methionine S-COMT methylates 2-hydroxyestradiol roughly twice as fast as it methylates 4-hydroxyestradiol Homo sapiens S-adenosyl-L-homocysteine + ? 395551 2.1.1.6 catechol O-methyltransferase 2-hydroxyestradiol + S-adenosyl-L-methionine - Homo sapiens S-adenosyl-L-homocysteine + 2-methoxyestradiol + 2-hydroxy-3-methoxyestradiol 407864 2.1.1.6 catechol O-methyltransferase 2-hydroxyestradiol + S-adenosyl-L-methionine - Homo sapiens 2-hydroxyestradiol 3-methyl ether + S-adenosyl-L-homocysteine 419904 2.1.1.6 catechol O-methyltransferase 2-hydroxyestradiol + S-adenosyl-L-methionine - Homo sapiens 2-methoxyestradiol + S-adenosyl-L-homocysteine 419905 2.1.1.6 catechol O-methyltransferase 2-hydroxyestradiol-17beta + S-adenosyl-L-methionine - Homo sapiens 2-methoxyestradiol-17beta + 2-hydroxyestradiol-17beta methyl ether + S-adenosyl-L-homocysteine 289675 2.1.1.6 catechol O-methyltransferase 4-hydroxyestradiol + S-adenosyl-L-methionine MCF-10F cells oxidize 4-hydroxyestradiol to estrone (estradiol)-3,4-quinones, which react with DNA to form the depurinating N3Ade and N7Gua adducts Homo sapiens (17beta)-estra-1(10),2,4-triene-3,4,17-triol + S-adenosyl-L-homocysteine + ? 394656 2.1.1.6 catechol O-methyltransferase 4-hydroxyestradiol + S-adenosyl-L-methionine - Homo sapiens S-adenosyl-L-homocysteine + ? 394657 2.1.1.6 catechol O-methyltransferase 4-hydroxyestradiol + S-adenosyl-L-methionine in the mammary gland, catechol estrogens are predominately inactivated by catechol-O-methyltransferase. in the isoflavone-induced. The estrogen receptor is involved in the down-regulation of COMT expression Homo sapiens S-adenosyl-L-homocysteine + ? 394657 2.1.1.6 catechol O-methyltransferase 4-hydroxyestradiol + S-adenosyl-L-methionine MB-COMT methylates both 2-hydroxyestradiol and 4-hydroxyestradiol at comparable rates Homo sapiens S-adenosyl-L-homocysteine + ? 394657 2.1.1.6 catechol O-methyltransferase 4-hydroxyestradiol + S-adenosyl-L-methionine S-COMT methylates 2-hydroxyestradiol roughly twice as fast as it methylates 4-hydroxyestradiol Homo sapiens S-adenosyl-L-homocysteine + ? 394657 2.1.1.6 catechol O-methyltransferase 4-hydroxyestradiol + S-adenosyl-L-methionine - Homo sapiens ? + S-adenosyl-L-homocysteine 420052 2.1.1.6 catechol O-methyltransferase S-adenosyl-L-methionine + 1-hydroxyestradiol - Homo sapiens S-adenosyl-L-homocysteine + ? 377624 2.1.1.6 catechol O-methyltransferase S-adenosyl-L-methionine + 2-hydroxyestradiol - Homo sapiens S-adenosyl-L-homocysteine + ? 377634 2.1.1.6 catechol O-methyltransferase S-adenosyl-L-methionine + 4-hydroxyestradiol - Homo sapiens S-adenosyl-L-homocysteine + ? 377657 2.4.1.17 glucuronosyltransferase 17alpha-estradiol + UDP-alpha-D-glucuronate - Homo sapiens ? + UDP 419799 2.4.1.17 glucuronosyltransferase 17beta-estradiol + UDP-alpha-D-glucuronate - Homo sapiens ? + UDP 419800 2.4.1.17 glucuronosyltransferase 17beta-estradiol + UDP-glucuronate metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7 Homo sapiens ? 387057 2.4.1.17 glucuronosyltransferase 2-hydroxyestradiol + UDP-glucuronate - Homo sapiens ? 387156 2.4.1.17 glucuronosyltransferase 2-hydroxyestradiol + UDPglucuronate - Homo sapiens UDP + 2-hydroxyestradiol O-glucuronide 322228 2.4.1.17 glucuronosyltransferase 4-hydroxyestradiol + UDP-glucuronate - Homo sapiens ? 387470 2.4.1.17 glucuronosyltransferase 4-hydroxyestradiol + UDPglucuronate - Homo sapiens UDP + 4-hydroxyestradiol O-glucuronide 322227 2.4.1.17 glucuronosyltransferase beta-estradiol + UDP-alpha-D-glucuronate - Homo sapiens beta-estradiol-3-glucuronide + UDP 420397 2.4.1.17 glucuronosyltransferase beta-estradiol + UDP-glucuronate - Homo sapiens UDP + beta-estradiol 3-O-beta-D-glucuronoside 455395 2.4.1.17 glucuronosyltransferase beta-estradiol + UDP-glucuronate - Homo sapiens UDP + beta-estradiol 3-O-glucuronide 455396 2.4.1.17 glucuronosyltransferase beta-estradiol + UDP-glucuronate - Homo sapiens UDP + beta-estradiol-3-glucuronide 455397 2.4.1.17 glucuronosyltransferase beta-estradiol + UDP-glucuronate substrate for isoform UGT1A1 Homo sapiens UDP + beta-estradiol-3-glucuronide 455397 2.4.1.17 glucuronosyltransferase beta-estradiol + UDPglucuronate inactive Homo sapiens beta-estradiol-3-glucuronide + UDP 322187 2.4.1.17 glucuronosyltransferase estradiol + UDP-alpha-D-glucuronate substrate of isoform UGT1A1 Homo sapiens UDP + estradiol 3-O-glucuronide 420664 2.4.1.17 glucuronosyltransferase estradiol + UDP-glucuronate - Homo sapiens ? 388653 2.4.1.17 glucuronosyltransferase estradiol + UDP-glucuronate sigmoidal kinetics with n of 1.7 Homo sapiens estradiol 3-O-glucuronate + UDP 420665 2.4.1.17 glucuronosyltransferase UDP-D-glucuronate + 17beta-estradiol - Homo sapiens UDP + 17beta-estradiol 3-O-beta-D-glucuronoside 399051 2.4.1.17 glucuronosyltransferase UDP-D-glucuronate + 17beta-estradiol - Homo sapiens UDP + 17beta-estradiol-3-O-beta-D-glucuronoside 402109 2.4.1.17 glucuronosyltransferase UDP-D-glucuronate + 2-hydroxyestradiol isozyme UGT1A1 Homo sapiens UDP + 2-hydroxyestradiol beta-D-glucuronoside 402111 2.4.1.17 glucuronosyltransferase UDP-D-glucuronate + beta-D-estradiol isozyme UGT1A1 Homo sapiens UDP + beta-estradiol 3-O-beta-D-glucuronoside 402128 2.4.1.17 glucuronosyltransferase UDP-D-glucuronate + beta-estradiol - Homo sapiens UDP + beta-estradiol 3-O-beta-D-glucuronoside 402129 2.4.1.17 glucuronosyltransferase UDP-D-glucuronate + estradiol isozymes UGT1A1 and UGT1A9 Homo sapiens UDP + estradiol 3-O-beta-D-glucuronoside 399074 2.4.1.17 glucuronosyltransferase UDP-D-glucuronate + estradiol reaction of isozyme UGT1A1 Homo sapiens UDP + estradiol 3-O-beta-D-glucuronoside 399074 2.4.1.17 glucuronosyltransferase UDP-D-glucuronate + estradiol liver microsomes Homo sapiens UDP + estradiol-3-beta-D-glucuronoside 399075 2.4.1.17 glucuronosyltransferase UDP-D-glucuronate + estradiol recombinant isozyme UGT1A1 Homo sapiens UDP + estradiol-3-beta-D-glucuronoside 399075 2.4.1.17 glucuronosyltransferase UDP-glucuronate + 17-alpha-estradiol very low activity Homo sapiens UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside 435981 2.4.1.17 glucuronosyltransferase UDP-glucuronate + 17-alpha-estradiol low activity Homo sapiens UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside 435981 2.4.1.17 glucuronosyltransferase UDP-glucuronate + 17-alpha-estradiol lower activity Homo sapiens UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside 435981