4.2.3.139 (2E,6E)-farnesyl diphosphate - Valeriana officinalis valerena-4,7(11)-diene + diphosphate - ? 419649 4.2.3.139 (2E,6E)-farnesyl diphosphate mechanism: C1 forms a bond with C11 of the originating farnesyl diphosphate molecule to form a caryophyllenyl carbocation followed by opening of the cyclobutyl ring to yield the desired isobutenyl side chain Valeriana officinalis valerena-4,7(11)-diene + diphosphate - ? 419649 4.2.3.139 additional information poor substrate: geranyl diphosphate Valeriana officinalis ? - ? 89