2.7.12.2 additional information - Schizosaccharomyces pombe ? - ? 89 2.7.12.2 additional information Pek1, in its unphosphorylated form, acts as a potent negative regulator of Pmk1 MAPK signalling. Mkh1, an upstream MAPKK kinase, converts Pek1 from being an inhibitor to an activator. Pek1 has a dual stimulatory and inhibitory function which depends on its phosphorylation state Schizosaccharomyces pombe ? - ? 89 2.7.12.2 additional information MEKK3 activates SEK and MEK, the known kinases targeting SAPK and ERK respectively Homo sapiens ? - ? 89 2.7.12.2 additional information enzyme is part of mitogen-activated protein kinase pathways, crosstalk and regulation mechanism, overview eukaryota ? - ? 89 2.7.12.2 additional information the enzyme performs autophosphorylation Leishmania mexicana ? - ? 89 2.7.12.2 additional information MEK1/2 are involved in the mitogen-activated protein kinase signaling pathway and in cancer tumorigenesis Homo sapiens ? - ? 89 2.7.12.2 additional information the enzyme is involved in the mitogen-activated protein kinase signaling pathway Rattus norvegicus ? - ? 89 2.7.12.2 additional information the enzyme is involved in the mitogen-activated protein kinase signaling pathway regulating cell dissociation of cancer cells, MEK2 is an invasion-metastasis related factor between highly and weakly invasive cells, occludin acts as antagonist Mesocricetus auratus ? - ? 89 2.7.12.2 additional information the enzyme is involved in the mitogen-activated protein kinase signaling pathway, pathway induction by neurotrophin stabilizes the axonal growth cone, pathway inhibitor semaphorin 3F induces growth cone collaps in sympathetic neurons and reduction of axonal growth Rattus norvegicus ? - ? 89 2.7.12.2 additional information the enzyme is involved in the mitogen-activated protein kinase signaling pathway, which is involved in e.g. activation of Egr-1 and subsequently of c-Fos and cyclin D1 after mechanic injury for induction/regulation of regrowth of smooth vascular cells, vascular smooth muscle cell proliferation plays an important role in pathogenesis of atherosclerosis and post-angioplasty restenosis, overview Rattus norvegicus ? - ? 89