2.7.11.10	additional information	activation of heterodimeric nuclear transcription factor NFkappaB is an essential step in inflammation, e.g. resulting in osteoarthritis, ulcerative colitis, asthma, and Crohn's disease, signalling step for phosphorylation, subsequent ubiquitination and proteolytic degradation of IkappaB, NFkappaB remains free after the reaction and is translocated to the nucleus, NFkappaB activation is also involved in development of diseases like cancer, gut ischemia-reperfusion, diabetes, or in transplant rejections, overview	Homo sapiens	?	-	?	89	
2.7.11.10	additional information	activation of NFkappaB by the catalytic subunit IKKbeta is required for signaling via the NFkappaB pathway in acute and systemic inflammation and for tissue protection	Mus musculus	?	-	?	89	
2.7.11.10	additional information	defective ubiquination of the NF-kappaB essential modifier/IkappaB kinase-gamma complex leads to impaired cellular NFkappaB signalling and hypohidrotic ectodermal dysplasia with immunodeficiency HED-ID	Homo sapiens	?	-	?	89	
2.7.11.10	additional information	enzyme is responsible for NFkappaB activation, specific inhibition of IkB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in male Sprague-Dawley rats	Homo sapiens	?	-	?	89	
2.7.11.10	additional information	IkappaB kinases are essential key regulators of the NFkappaB pathways in the tooth development acting as stimulators, overview	Mus musculus	?	-	?	89	
2.7.11.10	additional information	IKK activates and regulates NFkappaB important in intracellular signalling, overview	Homo sapiens	?	-	?	89	
2.7.11.10	additional information	IKK activates NF-kappaB through action of TNFalpha playing an important role in subsequent signaling pathways involved in e.g. apoptosis/cell survival, cell proliferation, and inflammation	Homo sapiens	?	-	?	89	
2.7.11.10	additional information	IKK activates NF-kappaB which initiates signaling pathways that play critical roles in a variety of physiological and pathological processes, e.g. promotion of cell survival inducing production of apoptosis inhibitors in normal and cancer cells, pathways overview, IKK/NF-kappaB links inflammation to cancer, regulation of IKK, overview	Mus musculus	?	-	?	89	
2.7.11.10	additional information	IKK activates NF-kappaB which initiates signaling pathways that play critical roles in a variety of physiological and pathological processes, e.g. promotion of cell survival inducing production of apoptosis inhibitors in normal and cancer cells, pathways overview, IKK/NF-kappaB links inflammation to cancer, regulation of IKK, overview	Homo sapiens	?	-	?	89	
2.7.11.10	additional information	IKK activates TNFalpha-dependent signaling pathways inducing 5-fluoro-2'-deoxyuridine drug resistance in different cell lines, overview	Homo sapiens	?	-	?	89