2.3.1.B41	additional information	insignificant activity with SKEYFS(N6-succinyl)KQK	Archaeoglobus fulgidus	?	-	?	89	
2.3.1.B41	additional information	no activity with KGLGKGGA(N6-succinyl)KRHRKW	Archaeoglobus fulgidus	?	-	?	89	
2.3.1.B41	additional information	no or very low activity with QTAR(N6-acetyl)KSTGG, QTAR(N6-propionyl)KSTGG, QTAR(N6-succinyl)KSTGG, QTAR(N6-butyryl)KSTGG, QTAR(N6-crotonyl)KSTGG	Homo sapiens	?	-	?	89	
2.3.1.B41	additional information	Sirt6 prefers long chain fatty acyl groups. Low deacetylase activity on histone H3 K9 and histone H3 K56. Selectivity for peptide sequence is not high	Homo sapiens	?	-	?	89	
2.3.1.B41	additional information	the enzyme preferentially hydrolyzes long-chain fatty acyl groups over acetyl groups in vitro	Homo sapiens	?	-	?	89	
2.3.1.B41	additional information	SIRT6 forms a complex with MutY homolog, apurinic/apyrimidinic-endonuclease 1, and 9-1-1 checkpoint clamp to maintain genomic and telomeric integrity. SIRT6 enhances the activities of MutY homolog, apurinic/apyrimidinic-endonuclease 1. Human MutY homolog and SIRT6 are efficiently recruited to confined oxidative DNA damage within transcriptionally active chromatin, but not in inactive chromatin	Mus musculus	?	-	?	89	
2.3.1.B41	additional information	acetylation of nicotinamide phosphoribosyltransferase, i.e. NAMPT, on residue K53 by SIRT6	Homo sapiens	?	-	-	89	
2.3.1.B41	additional information	SIRT6 deacetylates Beclin-1 in HCC cells	Homo sapiens	?	-	-	89	
2.3.1.B41	additional information	SIRT6 is a specific deacetylase for H3K9, see EC 2.3.1.286. It also deacetylates H3K56 and H3K18, as well as KAP1, CtIP, PGC-1alpha, TRF2, GCN5, SNF2H, and PKM2	Mus musculus	?	-	-	89	
2.3.1.B41	additional information	SIRT6 is a specific deacetylase for H3K9, see EC 2.3.1.286. It also deacetylates H3K56 and H3K18, as well as KAP1, CtIP, PGC-1alpha, TRF2, GCN5, SNF2H, and PKM2, cf. EC 2.3.1.286	Homo sapiens	?	-	-	89