2.3.1.221 7 malonyl-CoA + acetyl-[acyl-carrier protein] - Aspergillus parasiticus ? - ? 422704 2.3.1.221 7 malonyl-CoA + hexanoyl-[acyl-carrier protein] - Aspergillus parasiticus 7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O - ? 421824 2.3.1.221 7 malonyl-CoA + hexanoyl-[acyl-carrier protein] - Aspergillus sp. 7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O - ? 421824 2.3.1.221 7 malonyl-CoA + hexanoyl-[acyl-carrier protein] ACP-bound intermediates and major products of the reaction, overview Aspergillus parasiticus 7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O - ? 421824 2.3.1.221 additional information processivity of polyketide extension and substrate specificity, overview. The enzyme shows activity against hexanoyl- and acetyl-, but not malonyl-CoA. Rapid loading of extension units onto the carrier domain facilitates efficient chain extension in a manner kinetically favorable to ultimate product formation. Essential roles of the product template and thioesterase domains for cyclization and product release, editing role for the thioesterase domain Aspergillus parasiticus ? - ? 89