2.1.1.114	additional information	wide substrate specificity. The enzyme methylates both eukaryotic substrates demethylubiquinol-3 (this activity is classified as EC 2.1.1.64) and 3,4-dihydroxy-5-farnesylbenzoic acid and the distinct prokaryotic substrate 3-((2E,6E)-farnesyl)benzene-1,2-diol	Homo sapiens	?	-	?	89	
2.1.1.114	S-adenosyl-L-methionine + 3,4-dihydroxy-5-((2E,6E)-farnesyl)benzoate	-	Rattus norvegicus	S-adenosyl-L-homocysteine + 5-((2E,6E)-farnesyl)-4-hydroxy-3-methoxybenzoate	-	?	410189	
2.1.1.114	S-adenosyl-L-methionine + 3,4-dihydroxy-5-(2E,6E)-farnesylbenzoate	-	Saccharomyces cerevisiae	S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-farnesylbenzoate	-	?	410190	
2.1.1.114	S-adenosyl-L-methionine + 3,4-dihydroxy-5-(2E,6E)-farnesylbenzoate	in vitro assay	Homo sapiens	S-adenosyl-L-homocysteine + 5-(2E,6E)-farnesyl-4-hydroxy-3-methoxybenzoate	-	?	410191	
2.1.1.114	S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate	-	Saccharomyces cerevisiae	S-adenosyl-L-homocysteine + 5-all-trans-hexaprenyl-4-hydroxy-3-methoxybenzoate	-	?	407322	
2.1.1.114	S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate	3,4-dihydroxy-5-all-trans-hexaprenylbenzoate is an intermediate in biosynthesis of ubiquinone-6 in Saccharomyces cerevisiae (that is methylated by the yeast enzyme CoQ3 to 4-hydroxy-3-methoxy-5-hexaprenylbenzoate). When expressed in multicopy, the human construct rescues the growth of a yeast coq3 null mutant on a nonfermentable carbon source and restores coenzyme Q biosynthesis, although at lower levels than that of wild type yeast	Homo sapiens	S-adenosyl-L-homocysteine + 5-all-trans-hexaprenyl-4-hydroxy-3-methoxybenzoate	-	?	407322	
2.1.1.114	S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate	-	Homo sapiens	S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate	-	?	432926	
2.1.1.114	S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate	-	Caenorhabditis elegans	S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate	-	?	432926	
2.1.1.114	S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate	-	Escherichia coli	S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate	-	?	432926	
2.1.1.114	S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate	-	Caenorhabditis elegans N2	S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate	-	?	432926