1.2.1.75 additional information the bifunctional enzyme shows malonate semialdehyde reduction activity, EC 1.1.1.298, and also malonyl-CoA reduction activity. The C-terminal subdomain MCR-C reduces malonyl-CoA to malonate semialdehyde, while the N-terminal subdomain MCR-N reduces malonate semialdehyde to 3-HP Chloroflexus aurantiacus ? - - 89 1.2.1.75 additional information the bifunctional malonyl-CoA reductase catalyzes the formation of malonate semialdehyde from malonyl-CoA, and the reduction of malonate semialdehyde to 3-hydroxypropionate, cf. EC 1.1.1.298, molecular mechanism of the conversion of malonyl-CoA to 3-HP in the bacterial 3-HP pathway, substrate binding docking simulations, overview Erythrobacter dokdonensis ? - - 89 1.2.1.75 additional information the bifunctional malonyl-CoA reductase catalyzes the formation of malonate semialdehyde from malonyl-CoA, and the reduction of malonate semialdehyde to 3-hydroxypropionate, cf. EC 1.1.1.298, molecular mechanism of the conversion of malonyl-CoA to 3-HP in the bacterial 3-HP pathway, substrate binding docking simulations, overview Erythrobacter dokdonensis DSW-74 ? - - 89 1.2.1.75 malonate semialdehyde + NADPH + H+ - Chloroflexus aurantiacus 3-hydroxypropionic acid + NADP+ - ? 460209 1.2.1.75 malonate semialdehyde + NADPH + H+ - Erythrobacter dokdonensis 3-hydroxypropionic acid + NADP+ - ? 460209 1.2.1.75 malonyl-CoA + NADPH + H+ - Metallosphaera sedula malonate semialdehyde + coenzyme A + NADP+ - ? 405763 1.2.1.75 malonyl-CoA + NADPH + H+ - Chloroflexus aurantiacus malonate semialdehyde + NADP+ + CoA - ? 405764 1.2.1.75 malonyl-CoA + NADPH + H+ - Sulfurisphaera tokodaii malonate semialdehyde + CoA + NADP+ - ? 423815 1.2.1.75 malonyl-CoA + NADPH + H+ - Chloroflexus aurantiacus malonate semialdehyde + CoA + NADP+ - ? 423815 1.2.1.75 malonyl-CoA + NADPH + H+ - Erythrobacter dokdonensis malonate semialdehyde + CoA + NADP+ - ? 423815