1.2.1.75	malonate semialdehyde + NADPH + H+	-	Chloroflexus aurantiacus	3-hydroxypropionic acid + NADP+	-	?	460209	
1.2.1.75	malonyl-CoA + NADPH + H+	-	Chloroflexus aurantiacus	malonate semialdehyde + NADP+ + CoA	-	?	405764	
1.2.1.75	malonyl-CoA + NADPH + H+	-	Chloroflexus aurantiacus	malonate semialdehyde + CoA + NADP+	-	?	423815	
1.2.1.75	additional information	enzyme additionally catalyzes the second reduction step of malonate semialdehyde + NADPH + H+ to 3-hydroxypropionate + NADP+. Reverse reaction starting with 3-hydroxypropionate does not require CoA and probably stops at malonate semialdehyde. No substrates are acetyl-CoA, propionyl-CoA, succinyl-CoA, or glyoxylate	Chloroflexus aurantiacus	?	-	?	89	
1.2.1.75	additional information	the bifunctional enzyme shows malonate semialdehyde reduction activity, EC 1.1.1.298, and also malonyl-CoA reduction activity. The C-terminal subdomain MCR-C reduces malonyl-CoA to malonate semialdehyde, while the N-terminal subdomain MCR-N reduces malonate semialdehyde to 3-HP	Chloroflexus aurantiacus	?	-	-	89	
1.2.1.75	malonate semialdehyde + NADPH + H+	-	Erythrobacter dokdonensis	3-hydroxypropionic acid + NADP+	-	?	460209	
1.2.1.75	malonyl-CoA + NADPH + H+	-	Erythrobacter dokdonensis	malonate semialdehyde + CoA + NADP+	-	?	423815	
1.2.1.75	additional information	the bifunctional malonyl-CoA reductase catalyzes the formation of malonate semialdehyde from malonyl-CoA, and the reduction of malonate semialdehyde to 3-hydroxypropionate, cf. EC 1.1.1.298, molecular mechanism of the conversion of malonyl-CoA to 3-HP in the bacterial 3-HP pathway, substrate binding docking simulations, overview	Erythrobacter dokdonensis	?	-	-	89	
1.2.1.75	malonyl-CoA + NADPH + H+	-	Erythrobacter dokdonensis DSW-74	malonate semialdehyde + CoA + NADP+	-	?	423815	
1.2.1.75	additional information	the bifunctional malonyl-CoA reductase catalyzes the formation of malonate semialdehyde from malonyl-CoA, and the reduction of malonate semialdehyde to 3-hydroxypropionate, cf. EC 1.1.1.298, molecular mechanism of the conversion of malonyl-CoA to 3-HP in the bacterial 3-HP pathway, substrate binding docking simulations, overview	Erythrobacter dokdonensis DSW-74	?	-	-	89