1.1.1.71 additional information lactol substrates (4R,6S)-6-(chloromethyl)oxane-2,4-diol and (4R,6R)-6-butyloxane-2,4-diol for the biocatalytic oxidations are obtained from 2-deoxy-D-ribose 5-phosphate aldolase (DERA) catalyzed reactions of the corresponding acceptor aldehydes chloroacetaldehyde and pentanal, respectively and at least two equivalents of acetaldehyde as described previously. Development of an efficient biocatalytic process on pilot plant scale to oxidize the aliphatic hydroxylactol substrate (4R,6R)-6-butyloxane-2,4-diol to the corresponding lactone product (4R,6R)-6-butyl-4-hydroxyoxan-2-one employing the wild-type alcohol dehydrogenase ADHA Starmerella magnoliae ? - - 89 1.1.1.71 additional information substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol Pyrococcus horikoshii ? - - 89 1.1.1.71 additional information lactol substrates (4R,6S)-6-(chloromethyl)oxane-2,4-diol and (4R,6R)-6-butyloxane-2,4-diol for the biocatalytic oxidations are obtained from 2-deoxy-D-ribose 5-phosphate aldolase (DERA) catalyzed reactions of the corresponding acceptor aldehydes chloroacetaldehyde and pentanal, respectively and at least two equivalents of acetaldehyde as described previously. Development of an efficient biocatalytic process on pilot plant scale to oxidize the aliphatic hydroxylactol substrate (4R,6R)-6-butyloxane-2,4-diol to the corresponding lactone product (4R,6R)-6-butyl-4-hydroxyoxan-2-one employing the wild-type alcohol dehydrogenase ADHA Starmerella magnoliae DSMZ 70638 ? - - 89 1.1.1.71 additional information substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol Pyrococcus horikoshii DSM 12428 ? - - 89 1.1.1.71 additional information substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol Pyrococcus horikoshii NBRC 100139 ? - - 89 1.1.1.71 additional information substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol Pyrococcus horikoshii JCM 9974 ? - - 89 1.1.1.71 additional information substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol Pyrococcus horikoshii ATCC 700860 ? - - 89 1.1.1.71 additional information substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol Pyrococcus horikoshii OT-3 ? - - 89 1.1.1.71 (1R)-1-hydroxy-1-phenylpropan-2-one + NADPH + H+ - Ralstonia sp. (1R)-1-phenylpropane-1,2-diol + NADP+ - ? 438492 1.1.1.71 (2R)-2-hydroxy-1-(4-methoxyphenyl)propan-1-one + NADPH + H+ - Ralstonia sp. (2R)-1-(4-methoxyphenyl)propane-1,2-diol + NADP+ - ? 438509