6.3.5.10	adenosylcobyrinic acid a,c-diamide + ATP + L-glutamine + H2O	-	Escherichia coli	adenosylcobyric acid + ADP + phosphate + L-glutamate	-	?	369159	
6.3.5.10	adenosylcobyrinic acid a,c-diamide + ATP + L-glutamine + H2O	-	Pseudomonas denitrificans (nom. rej.)	adenosylcobyric acid + ADP + phosphate + L-glutamate	-	?	369159	
6.3.5.10	adenosylcobyrinic acid a,c-diamide + ATP + L-glutamine + H2O	vitamin B12 biosynthesis	Escherichia coli	adenosylcobyric acid + ADP + phosphate + L-glutamate	-	?	369159	
6.3.5.10	adenosylcobyrinic acid a,c-diamide + ATP + L-glutamine + H2O	-	Pseudomonas denitrificans (nom. rej.) SC510 RifT	adenosylcobyric acid + ADP + phosphate + L-glutamate	-	?	369159	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + ammonia + H2O	ammonia can replace L-glutamine as amide group donor, but L-glutamine is preferred	Pseudomonas denitrificans (nom. rej.)	ADP + phosphate + adenosylcobyric acid + ?	-	?	372438	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	-	Pseudomonas denitrificans (nom. rej.)	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	-	Salmonella enterica	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	-	Halobacterium sp.	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	biosynthesis of vitamin B12, cobalamin biosynthetic pathway	Pseudomonas denitrificans (nom. rej.)	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	CbiP is involved in the biosynthesis of adenosylcobalamin, i.e. vitamin B12, anaerobic pathway	Salmonella enterica	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	cobalamin biosynthetic pathway, involved in coenzyme B12 synthesis	Pseudomonas denitrificans (nom. rej.)	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	cobinamide biosynthesis	Halobacterium sp.	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	CobQ is involved in the biosynthesis of adenosylcobalamin, i.e. vitamin B12, aerobic pathway	Pseudomonas denitrificans (nom. rej.)	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	involved in cobalamin biosynthesis	Pseudomonas denitrificans (nom. rej.)	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	involved in the de novo cobinamide biosynthesis pathway	Salmonella enterica	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	CbiP catalyzes b, d, e, and g amidation	Salmonella enterica	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	CobQ amidates the side chains b, d, e, and g generating adenosylcobyric acid, requires glutamine as the amide donor	Pseudomonas denitrificans (nom. rej.)	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	CobQ catalyzes amidations at positions b, d, e and g	Pseudomonas denitrificans (nom. rej.)	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	CobQ contains an unusual Triad family, class I, glutamine amidotransferase domain with conserved Cys and His residues, but lacking the Glu residue of the catalytic triad, domain organization, model of substrate binding, catalytic mechanism, CobQ catalyzes amidation of the carboxyls b, d, e, and g in a strict order, one ATP molecule and one glutamine molecule are consumed for each amidation reaction	Pseudomonas denitrificans (nom. rej.)	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	enzyme catalyzes the stepwise amidation of carboxyl groups b, d, e, and g of cobyrinic acid a,c-diamide, four-step amidation sequence from cobyrinic acid a,c-diamide to cobyric acid via the formation of corbyrinic acid triamide, tetraamide, and pentaamide intermediates, the amidations are carried out in a specific order, enzyme is specific to coenzyme forms of substrates, no amidation of the carboxyl group at position f, L-glutamine is the preferred amide group donor	Pseudomonas denitrificans (nom. rej.)	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	biosynthesis of vitamin B12, cobalamin biosynthetic pathway	Pseudomonas denitrificans (nom. rej.) SC510 RifT	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	enzyme catalyzes the stepwise amidation of carboxyl groups b, d, e, and g of cobyrinic acid a,c-diamide, four-step amidation sequence from cobyrinic acid a,c-diamide to cobyric acid via the formation of corbyrinic acid triamide, tetraamide, and pentaamide intermediates, the amidations are carried out in a specific order, enzyme is specific to coenzyme forms of substrates, no amidation of the carboxyl group at position f, L-glutamine is the preferred amide group donor	Pseudomonas denitrificans (nom. rej.) SC510 RifT	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	-	Halobacterium sp. NRC-1	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	cobinamide biosynthesis	Halobacterium sp. NRC-1	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	cobalamin biosynthetic pathway, involved in coenzyme B12 synthesis	Pseudomonas denitrificans (nom. rej.) SC510 Rifr(pXL617)	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	CobQ catalyzes amidations at positions b, d, e and g	Pseudomonas denitrificans (nom. rej.) SC510 Rifr(pXL617)	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	-	Salmonella enterica TR6583	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O	involved in the de novo cobinamide biosynthesis pathway	Salmonella enterica TR6583	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	359197	
6.3.5.10	ATP + adenosylcobyrinic acid diamide + L-glutamine + H2O	four carboxylates attached to the corrinoid ring are amidated in a dissociative fashion. The four carboxylates are amidated in a sequence beginning with carboxylate e and followed in turn by carboxylates d, b, and g	Salmonella enterica subsp. enterica serovar Typhimurium	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	387954	
6.3.5.10	ATP + adenosylcobyrinic acid pentaamide + L-glutamine + H2O	-	Pseudomonas denitrificans (nom. rej.)	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	372439	
6.3.5.10	ATP + adenosylcobyrinic acid pentaamide + L-glutamine + H2O	four carboxylates attached to the corrinoid ring are amidated in a dissociative fashion. The four carboxylates are amidated in a sequence beginning with carboxylate e and followed in turn by carboxylates d, b, and g	Salmonella enterica subsp. enterica serovar Typhimurium	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	372439	
6.3.5.10	ATP + adenosylcobyrinic acid tetraamide + L-glutamine + H2O	two-step amidation	Pseudomonas denitrificans (nom. rej.)	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	372440	
6.3.5.10	ATP + adenosylcobyrinic acid tetraamide + L-glutamine + H2O	four carboxylates attached to the corrinoid ring are amidated in a dissociative fashion. The four carboxylates are amidated in a sequence beginning with carboxylate e and followed in turn by carboxylates d, b, and g	Salmonella enterica subsp. enterica serovar Typhimurium	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	372440	
6.3.5.10	ATP + adenosylcobyrinic acid triamide + L-glutamine + H2O	three-step amidation	Pseudomonas denitrificans (nom. rej.)	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	372441	
6.3.5.10	ATP + adenosylcobyrinic acid triamide + L-glutamine + H2O	four carboxylates attached to the corrinoid ring are amidated in a dissociative fashion. The four carboxylates are amidated in a sequence beginning with carboxylate e and followed in turn by carboxylates d, b, and g	Salmonella enterica subsp. enterica serovar Typhimurium	ADP + phosphate + adenosylcobyric acid + L-glutamate	-	?	372441	
6.3.5.10	cobinic acid a,c-diamide + ATP + L-glutamine + H2O	-	Pseudomonas denitrificans (nom. rej.)	cobinamide + ADP + phosphate + L-glutamate	-	?	369160	
6.3.5.10	cobinic acid a,c-diamide + ATP + L-glutamine + H2O	-	Pseudomonas denitrificans (nom. rej.) SC510 RifT	cobinamide + ADP + phosphate + L-glutamate	-	?	369160	
6.3.5.10	additional information	no amidation of adenosylcobyric acid, hydrogenobyrinic acid a,c-diamide, monocyano or diaqua form of cobyrinic acid a,c-diamide	Pseudomonas denitrificans (nom. rej.)	?	-	?	89	
6.3.5.10	additional information	no amidation of adenosylcobyric acid, hydrogenobyrinic acid a,c-diamide, monocyano or diaqua form of cobyrinic acid a,c-diamide	Pseudomonas denitrificans (nom. rej.) SC510 RifT	?	-	?	89