4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol	-	Escherichia coli	2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP	-	?	165638	
4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol	-	Mycobacterium tuberculosis	2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP	-	?	165638	
4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol	-	Brassica rapa	2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP	-	?	165638	
4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol	-	Rauvolfia verticillata	2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP	-	?	165638	
4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol	-	Ginkgo biloba	2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP	-	?	165638	
4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol	-	Plasmodium falciparum	2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP	-	?	165638	
4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol	-	Arabidopsis thaliana	2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP	-	?	165638	
4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol	-	Stevia rebaudiana	2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP	-	?	165638	
4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol	-	Plasmodium falciparum NF54	2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP	-	?	165638	
4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol	-	Mycobacterium tuberculosis H37Rv	2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP	-	?	165638	
4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol	-	Mycobacterium tuberculosis	2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP	-	?	370786	
4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol	-	Escherichia coli	2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP	-	?	370786	
4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol	-	Plasmodium falciparum	2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP	-	?	370786	
4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol	-	Hevea brasiliensis	2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP	-	?	370786	
4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol	-	Cephalotaxus harringtonia	2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP	-	?	370786	
4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol	-	Mycobacterium tuberculosis Rv3582c	2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP	-	?	370786	
4.6.1.12	additional information	active site including CDP-binding sites (Asp140Gly142 and Leu184Leu189Ser190Lys216Thr217Glu219). Owns a 60 amino-acid plastidial transit peptide at its N-terminus	Taxus x media	?	-	?	89	
4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol	at low rate	Plasmodium falciparum	2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP	-	?	370786	
4.6.1.12	4-diphosphocytidyl-2C-methyl-D-erythritol	at low rate	Plasmodium falciparum	2C-methyl-D-erythritol 3,4-cyclophosphate + CMP	-	?	371936	
4.6.1.12	additional information	bifunctional 4-diphosphocytidyl-2C-methyl-D-erythritol synthase/2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase enzyme associates in solution with 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, i.e. ispE protein. No evidence for substrate channeling during the three enzyme’s subsequent catalytic reactions	Agrobacterium tumefaciens	?	-	?	89	
4.6.1.12	additional information	depletion of MEC synthase has an early and significant impact on cell wall biosynthesis and leads ultimately to cell death	Escherichia coli	?	-	?	89	
4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol	involved in mevalonate-independent biosynthesis of isoprenoids	Escherichia coli	2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP	-	?	165638	
4.6.1.12	2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol	nonmevalonate pathway of isoprenoid biosynthesis	Plasmodium falciparum	2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP	-	?	370786