3.6.1.28 ATP + H2O - Rattus norvegicus ADP + phosphate - ? 92967 3.6.1.28 ATP + H2O no activity Bos taurus ADP + phosphate - ? 92967 3.6.1.28 ATP + H2O no activity with enzyme from brain and liver Rattus norvegicus ADP + phosphate - ? 92967 3.6.1.28 ATP + H2O 4% of the activity with thiamine triphosphate Rattus norvegicus ADP + phosphate - ? 92967 3.6.1.28 ATP + H2O the catalytic efficiency is about 4 orders of magnitude lower than for thiamine triphosphate Homo sapiens ADP + phosphate - ? 92967 3.6.1.28 CTP + H2O - Rattus norvegicus CDP + phosphate - ? 93269 3.6.1.28 CTP + H2O no activity Bos taurus CDP + phosphate - ? 93269 3.6.1.28 CTP + H2O at 13% of the activity with thiamine triphosphate Rattus norvegicus CDP + phosphate - ? 93269 3.6.1.28 CTP + H2O 18% of the activity with thiamine triphosphate with liver enzyme, no activity with brain enzyme Rattus norvegicus CDP + phosphate - ? 93269 3.6.1.28 GTP + H2O - Rattus norvegicus GDP + phosphate - ? 73741 3.6.1.28 GTP + H2O no activity Bos taurus GDP + phosphate - ? 73741 3.6.1.28 GTP + H2O at 13% of the activity with thiamine triphosphate Rattus norvegicus GDP + phosphate - ? 73741 3.6.1.28 GTP + H2O 14% of the activity with thiamine triphosphate with liver enzyme, no activity with brain enzyme Rattus norvegicus GDP + phosphate - ? 73741 3.6.1.28 GTP + H2O at 4% of the activity with thiamine triphosphate Rattus norvegicus GDP + phosphate - ? 73741 3.6.1.28 ITP + H2O - Bos taurus IDP + phosphate - ? 93271 3.6.1.28 ITP + H2O no activity Bos taurus IDP + phosphate - ? 93271 3.6.1.28 ITP + H2O 18% of the activity with thiamine triphosphate with liver enzyme, no activity with brain enzyme Rattus norvegicus IDP + phosphate - ? 93271 3.6.1.28 additional information Thtpa is known to decrease the levels of the energy currency molecule, thiamine triphosphate Homo sapiens ? - ? 89 3.6.1.28 additional information Thtpa is known to decrease the levels of the energy currency molecule, thiamine triphosphate Rattus norvegicus ? - ? 89 3.6.1.28 thiamin triphosphate + H2O - Rattus norvegicus thiamine diphosphate + phosphate - ? 374709 3.6.1.28 thiamine diphosphate + H2O no activity Bos taurus thiamine monophosphate + phosphate - ? 141322 3.6.1.28 thiamine diphosphate + H2O 28% of the activity with thiamine triphosphate with liver enzyme, 6% of the activity with thiamine triphosphate with brain enzyme Rattus norvegicus thiamine monophosphate + phosphate - ? 141322 3.6.1.28 thiamine triphosphate + H2O - Gallus gallus thiamine diphosphate + phosphate - ? 141321 3.6.1.28 thiamine triphosphate + H2O - Escherichia coli thiamine diphosphate + phosphate - ? 141321 3.6.1.28 thiamine triphosphate + H2O - Homo sapiens thiamine diphosphate + phosphate - ? 141321 3.6.1.28 thiamine triphosphate + H2O - Rattus norvegicus thiamine diphosphate + phosphate - ? 141321 3.6.1.28 thiamine triphosphate + H2O - Sus scrofa thiamine diphosphate + phosphate - ? 141321 3.6.1.28 thiamine triphosphate + H2O - Bos taurus thiamine diphosphate + phosphate - ? 141321 3.6.1.28 thiamine triphosphate + H2O - Electrophorus electricus thiamine diphosphate + phosphate - ? 141321 3.6.1.28 thiamine triphosphate + H2O - quail thiamine diphosphate + phosphate - ? 141321 3.6.1.28 thiamine triphosphate + H2O - Aneurinibacillus aneurinilyticus thiamine diphosphate + phosphate - ? 141321 3.6.1.28 thiamine triphosphate + H2O - Mus musculus thiamine diphosphate + phosphate - ? 141321 3.6.1.28 thiamine triphosphate + H2O absolute specificity Homo sapiens thiamine diphosphate + phosphate - ? 141321 3.6.1.28 thiamine triphosphate + H2O absolute specificity Bos taurus thiamine diphosphate + phosphate - ? 141321 3.6.1.28 thiamine triphosphate + H2O thiamine triphosphate may play an important role in the regulation of Cl- permeability Electrophorus electricus thiamine diphosphate + phosphate - ? 141321 3.6.1.28 thiamine triphosphate + H2O enzyme is involved in thiamine metabolism Rattus norvegicus thiamine diphosphate + phosphate - ? 141321 3.6.1.28 thiamine triphosphate + H2O the enzyme may play a general role in neuronal metabolism rather than a specific role in excitability. There is no apparent correlation between enzyme expression and selective vulnerability of certain brain regions to thiamine deficiency Rattus norvegicus thiamine diphosphate + phosphate - ? 141321 3.6.1.28 thiamine triphosphate + H2O the enzyme is very specific for thiamine triphosphate, mechanism, overview, binding of Mg2+ induces only a minor local conformational change, whereas ThTP binding causes a more global conformational change, free mThTPase has an open cleft fold, the enzyme in the ternary complex adopts a tunnel fold, overview Mus musculus thiamine diphosphate + phosphate - ? 141321 3.6.1.28 thiamine triphosphate + H2O thiamine triphosphate as Mg2+-thiamine triphosphate complex Rattus norvegicus thiamine diphosphate + phosphate - ? 141321 3.6.1.28 thiamine triphosphate + H2O - Escherichia coli W 1485 thiamine diphosphate + phosphate - ? 141321 3.6.1.28 UTP + H2O - Rattus norvegicus UDP + phosphate - ? 73742 3.6.1.28 UTP + H2O no activity Rattus norvegicus UDP + phosphate - ? 73742 3.6.1.28 UTP + H2O no activity Bos taurus UDP + phosphate - ? 73742 3.6.1.28 UTP + H2O 29% of the activitry with thiamine triphosphate with liver enzyme, no activity with brain enzyme Rattus norvegicus UDP + phosphate - ? 73742 3.6.1.28 UTP + H2O at 2% of the activity with thiamine triphosphate Rattus norvegicus UDP + phosphate - ? 73742